Publications - Page 1
| Authors | Citation | Abstract | Title | Delivery Method | Organism |
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| Ahn DG, Kourakis MJ, Rohde LA, Silver LM, Ho RK | Nature 2002 Jun 13;417(6890):754-8 | The T-box genes Tbx4 and Tbx5 have been shown to have key functions in the specification of the i... | T-box gene tbx5 is essential for formation of the pectoral limb bud. | Microinjection | zebrafish |
| Akagi K, Kyun Park E, Mood K, Daar IO | Dev Dyn. 2002 Mar;223(2):216-28. | The docking protein SNT1/FRS2 (fibroblast growth factor receptor substrate 2) is implicated in th... | Docking protein SNT1 is a critical mediator of fibroblast growth factor signaling during Xenopus ... | Microinjection | Xenopus |
| Amatruda J.F., Shepard J.L., Stern H.M., Zon L.I | Cancer Cell 2002. 1(3): 229-231. | The zebrafish, with its combination of forward genetics and vertebrate biology, has great potenti... | Zebrafish as a cancer model system. | Microinjection | zebrafish |
| Amacher SL, Draper BW, Summers BR, Kimmel CB | Development 2002 129(14):3311-3323 | T-box genes encode transcriptional regulators that control many aspects of embryonic development.... | The zebrafish T-box genes no tail and spadetail are required for development of trunk and tail me... | Microinjection | zebrafish |
| Andermann P, Ungos J, Raible DW | Dev Biol. 2002 Nov 1;251(1):45-58 | Cells delaminate from epithelial placodes to form sensory ganglia in the vertebrate head. We desc... | Neurogenin1 Defines Zebrafish Cranial Sensory Ganglia Precursors | Microinjection | zebrafish |
| Angerer LM, Oleksyn DW, Levine AM, Li X, Klein WH, Angerer RC | Development. 2001 Nov;128(22):4393-404 | We have identified a single homolog of goosecoid, SpGsc, that regulates cell fates along both the... | Sea urchin goosecoid function links fate specification along the animal-vegetal and oral-aboral e... | Microinjection | sea urchin |
| Arora V, Hannah TL, Iversen PL, Brand RM | Pharm Res. 2002 Oct;19(10):1465-70 | PURPOSE: To determine if dermal absorption of an antisense phosphorodiamidate Morpholino oligomer... | Transdermal use of phosphorodiamidate morpholino oligomer AVI-4472 inhibits cytochrome P450 3A2 a... | transdermal | Sprague Dawley rats & hairless CRL:SK1 mice |
| Arora V, Cate ML, Ghosh C, Iversen PL | Drug Metab Dispos. 2002 Jul 1;30(7):757-762 | Antisense phosphorodiamidate morpholino oligomers (PMO) inhibit targeted gene expression by preve... | Phosphorodiamidate Morpholino Antisense Oligomers Inhibit Expression of Human Cytochrome P450 3A4... | Special Delivery | cell culture: hepatocytes (human primary cells), Caco-2/h3A4 cells |
| Arora V, Knapp DC, Reddy MT, Weller DD, Iversen PL. | J Pharm Sci. 2002 Apr;91(4):1009-18 | Antisense phosphorodiamidate Morpholino oligomers (PMO) are resistant to degradation by cellular ... | Bioavailability and efficacy of antisense morpholino oligomers targeted to c-myc and cytochrome P... | in vivo: injection | rats, Sprague Dawley |
| Arora V, Iversen PL | Curr Opin Mol Ther. 2001 Jun;3(3):249-57. Review. | The cytochrome P450 (CYP) family is the most catalytically versatile component of the phase I oxi... | Redirection of drug metabolism using antisense technology | not applicable | not applicable |
| Arora, V and Iversen, P.L. | Drug Metab. And Disp. 2000. 28(2):131-138 | The rapidly proliferating cells of the regenerating liver after partial hepatectomy (PH) present ... | Antisense oligonucleotides targeted to the p53 gene modulate rat liver regeneration | in vivo: injection | rats, Sprague Dawley |
| Arora V, Knapp DC, Smith BL, Statdfield ML, Stein DA, Reddy MT, Weller DD, Iversen PL | Exp Ther 2000 Mar 292(3):921-8 | Expression of c-myc protein is associated with cell proliferation. The present study uses antisen... | c-Myc antisense limits rat liver regeneration and indicates role for c-Myc in regulating cytochro... | Injection | rats, Sprague Dawley |
| Agathon A, Thisse B, Thisse C | Genesis. 2001 Jul;30(3):178-82 | No abstract available | Morpholino knock-down of antivin1 and antivin2 upregulates nodal signaling | Microinjection | zebrafish |
| Araki I, Brand M | Genesis. 2001 Jul;30(3):157-9 | No abstract available | Morpholino-induced knockdown of Fgf8 efficiently phenocopies the acerebellar (ACE) phenotype | Microinjection | zebrafish |
| Audic Y, Boyle B, Slevin M, Hartley RS | Genesis. 2001 Jul;30(3):107-9 | No abstract available. | Cyclin E morpholino delays embryogenesis in Xenopus | Microinjection | Xenopus |
| Bai RY, Koester C, Ouyang T, Hahn SA, Hammerschmidt M, Peschel C, Duyster J | Nat Cell Biol 2002 Mar;4 (3):181-90 | Proteins of the transforming growth factor beta(TGFbeta) superfamily regulate diverse cellular re... | SMIF, a Smad4-interacting protein that functions as a co-activator in TGF [beta] signalling | Microinjection | zebrafish |
| Basye J, Trent JO, Gao D, Ebbinghaus SW | Nucleic Acids Res 2001 Dec 1;29(23):4873-80 | Triplex-forming oligonucleotides (TFOs) are good candidates to be used as site-specific DNA-bindi... | Triplex formation by morpholino oligodeoxyribonucleotides in the HER-2/neu promoter requires the ... | not applicable | not applicable |
| Bauer H, Lele Z, Rauch GJ, Geisler R, Hammerschmidt M | Development 2001 128(6):849-858 | Ventral specification of mesoderm and ectoderm depends on signaling by members of the bone morpho... | The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transd... | Microinjection | zebrafish |
| Behra M, Cousin X, Bertrand C, Vonesch JL, Biellmann D, Chatonnet A, Strahle U | Nat Neurosci. 2002 Feb;5(2):111-8 | The neurotransmitter acetylcholine (ACh) has a crucial role in central and neuromuscular synapses... | Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo | Microinjection | zebrafish |
| Bingham S, Nasevicius A, Ekker SC, Chandrasekhar A | Genesis 2001 Jul;30(3):170-4 | No abstract available. | Sonic hedgehog and tiggy-winkle hedgehog cooperatively induce zebrafish branchiomotor neurons | Microinjection | zebrafish |
| Boonanuntanasarn S, Yoshizaki G, Takeuchi Y, Morita T, and Takeuchi T | Marine Biotechnology 2002. 4:256-266 | Gene knock-down technology using antisense molecules has many applications for studying gene func... | Gene Knock-down in Rainbow Trout Embryos Using Antisense Morpholino Phosphorodiamidate Oligonucle... | Microinjection | rainbow trout |
| Bota DA, Davies KJ | Nat Cell Biol 2002 Sep;4(9):674-680 | Mitochondrial aconitase is sensitive to oxidative inactivation and can aggregate and accumulate i... | Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechan... | Special Delivery | cell culture: human fibroblasts WI-38 VA-13 |
| Braat AK, van De Water S, Korving J, Zivkovic D. | Genesis. 2001 Jul;30(3):183-5 | No abstract available. | A zebrafish vasa morphant abolishes Vasa protein but does not affect the establishment of the ger... | Microinjection | zebrafish |
| Brand, R.M. and Iversen, P.L. | Advances Drug Devel. Reviews. 2000. 44(1): 51-57 | The potential for using antisense compounds as therapeutic agents has generated great enthusiasm.... | Transdermal delivery of antisense compounds | transdermal | not applicable |
| Branford WW, Yost HJ | Curr Biol. 2002 Dec 23;12(24):2136-41 | During gastrulation, diffusible "organizer" signals, including members of the TGFbeta Nodal subfa... | Lefty-dependent inhibition of nodal- and wnt-responsive organizer gene expression is essential fo... | Microinjection | Xenopus |
| Braun S, Hanselmann C, Gassmann MG, auf dem Keller U, Born-Berclaz C, Chan K, Kan YW, Werner S | Mol Cell Biol. 2002 Aug;22(15):5492-505 | Keratinocyte growth factor (KGF) is a potent mitogen for epithelial cells, and it promotes surviv... | Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates ge... | Special Delivery | cell culture: mouse primary keratinocytes |
| Brent L, Drapeau P | Neuroscience 2002 Oct 1;114(2):275 | We have examined whether antisense morpholino oligonucleotides (morpholinos) can be used as a too... | Targeted 'knockdown' of channel expression in vivo with an antisense morpholino oligonucleotide | Microinjection | zebrafish |
| Burgess S, Reim G, Chen W, Hopkins N, Brand M | Development. 2002 Feb; 129(4):905-916 | n early embryonic development, the brain is divided into three main regions along the anteroposte... | The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammal... | Microinjection | zebrafish |
| Carl M, Loosli F, Wittbrodt J | Development. 2002 Sep;129(17):4057-63 | The establishment of retinal identity and the subsequent patterning of the optic vesicle are the ... | Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate e... | Microinjection | medaka embryos |
| Chakhmakhcheva, O., Andrianov, M., Buryakova, A., Choob, M., & Efimov, V | Nucleosides Nucleotides 1999 18:1427-1428 | The solid phase synthesis of the three types of morpholino analogues of nucleic acids has been ac... | Synthesis and properties of some morpholino oligonucleotide analogues | | |
| Chan J, Bayliss P.E., Wood J.M., Roberts T.M. | Cancer Cell. 2002. 1(3):257-267 | Striking homology between signaling molecules in zebrafish and humans suggests that compounds kno... | Dissection of angiogenic signaling in zebrafish using a chemical genetic approach | Microinjection | zebrafish |
| Chen YH, Tsai HJ | Differentiation. 2002 Oct;70(8):447-56 | Myf-5 is a stage-dependent transcription factor associated with somitogenesis. To study its biolo... | Treatment with Myf5-morpholino results in somite patterning and brain formation defects in zebraf... | Microinjection | zebrafish |
| Childs S, Chen JN, Garrity DM, Fishman MC | Development. 2002 Feb;129(4):973-8 | Little is known about how vascular patterns are generated in the embryo. The vasculature of the ... | Patterning of angiogenesis in the zebrafish embryo | Microinjection | zebrafish |
| Ciruna B, Weidinger G, Knaut H, Thisse B, Thisse C, Raz E, Schier AF | Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14919-24. Epub 2002 Oct 23. | We report a generally applicable strategy for transferring zygotic lethal mutations through the z... | Production of maternal-zygotic mutant zebrafish by germ-line replacement | Microinjection | zebrafish |
| Collavin L, Kirschner MW | Development. 2003 Feb;130(4):805-16 | The prevailing model of dorsal ventral patterning of the amphibian embryo predicts that the prosp... | The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extre... | Microinjection | Xenopus |
| Coonrod SA, Bolling LC, Wright PW, Visconti PE, Herr JC | Genesis. 2001 Jul;30(3):198-200 | No abstract available. | A morpholino phenocopy of the mouse MOS mutation | Microinjection | mouse oocytes |
| Corey DR, Abrams JM | Genome Biology 2001 2(5): reviews1015.1-1015.3 | Antisense oligonucleotides provide a promising approach to investigating gene function in vivo, b... | Morpholino antisense oligonucleotides: tools for investigating vertebrate development | not applicable | not applicable |
| Cornell RA, Eisen JS | Development. 2002 Jun;129(11):2639-48 | In zebrafish, cells at the lateral edge of the neural plate become Rohon-Beard primary sensory ne... | Delta/Notch signaling promotes formation of zebrafish neural crest by repressing Neurogenin 1 fun... | Microinjection | zebrafish |
| Crosier PS, Kalev-Zylinska ML, Hall CJ, Flores MV, Horsfield JA, Crosier KE | Int J Dev Biol. 2002;46(4):493-502 | Studies in zebrafish have potential to contribute to understanding of the vertebrate hematopoieti... | Pathways in blood and vessel development revealed through zebrafish genetics | not applicable | zebrafish |
| Cui Z, Clark KJ, Kaufman CD, Hackett PB | Genesis. 2001 Jul;30(3):149-53 | No abstract available. | Inhibition of skiA and skiB gene expression ventralizes zebrafish embryos | Microinjection | zebrafish |
| Dagle JM, Weeks DL | Differentiation. 2001 Dec;69(2-3):75-82. | Research on embryonic development and differentiation provides a sensitive, but challenging oppor... | Oligonucleotide-based strategies to reduce gene expression | not applicable | not applicable |
| Dahmane N, Sanchez P, Gitton Y, Palma V, Sun T, Beyna M, Weiner H and Altaba AR | Development 2001 128:5201-5212 | The mechanisms that regulate the growth of the brain remain unclear. We show that Sonic hedgehog ... | The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis | Microinjection | Xenopus |
| Darken RS, Scola AM, Rakeman AS, Das G, Mlodzik M, Wilson PA | EMBO J. 2002 Mar; 21(5):976-985 | The signaling mechanisms that specify, guide and coordinate cell behavior during embryonic morpho... | The planar polarity gene strabismus regulates convergent extension movements in Xenopus | Microinjection | Xenopus |
| Davidson G, Mao B, Del Barco Barrantes I, Niehrs C | Development. 2002 Dec;129(24):5587-96 | A gradient of Wnt/beta-catenin signalling formed by posteriorising Wnts and anteriorising Wnt ant... | Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning | Microinjection | Xenopus |
| Davidson EH, Rast JP, Oliveri P, Ransick A, Calestani C, Yuh CH, Minokawa T, Amore G, Hinman V, A... | Dev Biol. 2002 Jun 1;246(1):162-90 | We present the current form of a provisional DNA sequence-based regulatory gene network that expl... | A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo | Microinjection | Sea urchins |
| Deardorff MA, Tan C, Saint-Jeannet JP, Klein PS | Development 2001 Oct 1;128(19):3655-3663 | Wnts are a large family of secreted molecules implicated in numerous developmental processes. Fri... | A role for frizzled 3 in neural crest development. | Microinjection | Xenopus |
| Deng J, Hua K, Lesser SS, Harp JB | Endocrinology 2000 Jul;141(7):2370-6 | Signal transducer and activator of transcription-3 (STAT3) is abundantly expressed in preadipocyt... | Activation of signal transducer and activator of transcription-3 during proliferative phases of 3... | Scrape Delivery | cell culture: 3T3-L1 preadipocytes |
| Devi GR | Curr Opin Mol Ther. 2002 Apr;4(2):138-48. Review. | Prostate cancer, like most other solid tumors, represents a heterogeneous entity consisting of a ... | Prostate cancer: status of current treatments and emerging antisense-based therapies | | |
| Devi GR, Oldenkamp JR, London CA, Iversen PL | Prostate. 2002 Nov 1;53(3):200-10 | BACKGROUND: Amplification of the proto-oncogene c-myc has been identified as one of the most comm... | Inhibition of human chorionic gonadotropin beta-subunit modulates the mitogenic effect of c-myc i... | culture: scrape loading and syringe loading; mouse: IP injection | cultures & mice: human DU145, PC-3, LNCaP prostate cancer lines, male athymic (Ncr nu/nu) mice |
| Dibner C, Elias S, Frank D | Development. 2001 Sep;128(18):3415-26 | Meis-family homeobox proteins have been shown to regulate cell fate specification in vertebrate a... | XMeis3 protein activity is required for proper hindbrain patterning in Xenopus laevis embryos | Microinjection | Xenopus |
