Publications - Page 3
| Authors | Citation | Abstract | Title | Delivery Method | Organism |
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| Jubin R, Vantuno NE, Kieft JS, Murray MG, Doudna JA, Lau JY, Baroudy BM | J Virol 2000 Nov 15;74(22):10430-10437 | The hepatitis C virus (HCV) internal ribosome entry site (IRES) is a highly structured RNA elemen... | Hepatitis C Virus Internal Ribosome Entry Site (IRES) Stem Loop IIId Contains a Phylogenetically ... | in vitro: TNT | Hepatitis C virus |
| Kalev-Zylinska ML, Horsfield JA, Flores MV, Postlethwait JH, Vitas MR, Baas AM, Crosier PS, Crosi... | Development. 2002 Apr;129(8):2015-30 | RUNX1/AML1/CBFA2 is essential for definitive hematopoiesis, and chromosomal translocations affect... | Runx1 is required for zebrafish blood and vessel development and expression of a human RUNX1-CBF2... | Microinjection | zebrafish |
| Kaneko K, Satoh K, Masamune A, Satoh A, Shimosegawa T | Pancreas. 2002 Apr;24(3):251-7 | INTRODUCTION: Invasion and metastasis of cancer cells require cell motility and adhesion. The sma... | Expression of ROCK-1 in Human Pancreatic Cancer: Its Down-Regulation by Morpholino Oligo Antisens... | culture: Incubation & free uptake | Cell Culture: human pancreatic cell: MIA PaCa-2, and Panc-1 |
| Kang H, Chou PJ, Johnson WC Jr, Weller D, Huang SB, Summerton JE | Biopolymers 1992 Oct;32(10):1351-63 | CD spectra have been measured as a function of temperature for a number of ApA analogues with mod... | Stacking interactions of ApA analogues with modified backbones | | |
| Karlen S, Rebagliati M | Genesis. 2001 Jul;30(3):126-8 | No abstract available. | A morpholino phenocopy of the cyclops mutation | Microinjection | zebrafish |
| Kassel O, Sancono A, Kratzschmar J, Kreft B, Stassen M, Cato AC | EMBO J. 2001 Dec 17;20(24):7108-16 | Glucocorticoids inhibit the proinflammatory activities of transcription factors such as AP-1 and ... | Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1 | Scrape Delivery | cell culture: mast cells |
| Kato Y, Habas R, Katsuyama Y, Naar AM, He X | Nature. 2002 Aug 8;418(6898):641-6 | The transforming growth factor beta (TGF beta) family of cytokines, including Nodal, Activin and ... | A component of the ARC/Mediator complex required for TGF beta/Nodal signalling | Microinjection | Xenopus laevis |
| Kawachi K, Masuyama N, Nishida E | J Biol Chem. 2003 Feb 14;278(7):5473-7. Epub 2002 Dec 04 | The fibroblast growth factor (FGF)/MAPK pathway plays an important role in early Xenopus developm... | Essential role of the transcription factor Ets-2 in Xenopus early development | Microinjection | Xenopus |
| Kawahara A, Dawid IB | Curr Biol. 2001 Sep 4;11(17):1353-7 | Hematopoietic cells arise from ventral mesoderm in different vertebrates, but the mechanisms thro... | Critical role of biklf in erythroid cell differentiation in zebrafish | Microinjection | zebrafish |
| Kawahara A, Chien CB, Dawid IB | Dev Biol. 2002 Aug 1;248(1):107-17 | The homeobox gene mbx is first activated at the end of gastrulation in zebrafish in the presumpti... | The Homeobox Gene mbx Is Involved in Eye and Tectum Development | Microinjection | zebrafish |
| Khokha MK, Chung C, Bustamante EL, Gaw LW, Trott KA, Yeh J, Lim N, Lin JC, Taverner N, Amaya E, P... | Dev Dyn. 2002 Dec;225(4):499-510 | The frog Xenopus laevis has provided significant insights into developmental and cellular process... | Techniques and probes for the study of Xenopus tropicalis development. | Microinjection | X.laevis & X.tropicalis |
| Kim SH, Shin J, Park HC, Yeo SY, Hong SK, Han S, Rhee M, Kim CH, Chitnis AB, Huh TL | Development. 2002 Oct;129(19):4443-55 | Wnts have been shown to provide a posteriorizing signal that has to be repressed in the anterior ... | Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling dur... | Microinjection | zebrafish |
| Kipshidze N, Moses J, Shankar LR, Leon M | Curr Opin Mol Ther 2001 Jun;3(3):265-77 | One of the potential clinical applications of antisense therapy is the prevention or treatment of... | Perspectives on antisense therapy for the prevention of restenosis | | |
| Kipshidze NN, Kim HS, Iversen P, Yazdi HA, Bhargava B, New G, Mehran R, Tio F, Haudenschild C, Da... | J Am Coll Cardiol 2002 May 15;39(10):1686-91 | OBJECTIVES: We evaluated the long-term influence of intramural delivery of advanced c-myc neutral... | Intramural coronary delivery of advanced antisense oligonucleotides reduces neointimal formation ... | Infiltrator Balloon Catheter with PMO infused intramurally via drug delivery InjectorPortsTM | pig |
| Kipshidze, N., Keane, E., Stein, D., Chawla, P., Skrinska, V., Shandar, L.R., Komorowski, R., Hau... | XXIst Congress of the European Society of Cardiology, Ed. Francisco Navarro-Lopez, Monduzzi Edito... | | Local delivery of antisense phosphorodiamidate morpholino oligomer; Resten-NG inhibits myointimal... | | |
| Knapp DC, Mata JE, Reddy MT, Devi GR, Iversen PL | Anticancer Drugs. 2003 Jan;14(1):39-47 | Chemotherapy resistance is a significant obstacle in lung cancer therapy, and has been found to f... | Resistance to chemotherapeutic drugs overcome by c-Myc inhibition in a Lewis lung carcinoma murin... | In vivo: injection and cell culture | C57BL/6 mice with LLC cell injected |
| Kobayashi H, Spilde TL, Bhatia AM, Buckingham RB, Hembree MJ, Prasadan K, Preuett BL, Imamura M, ... | Gastroenterology. 2002 Oct;123(4):1331-40 | BACKGROUND & AIMS: The early embryonic pancreas gives rise to exocrine (ducts and acini) and endo... | Retinoid signaling controls mouse pancreatic exocrine lineage selection through epithelial-mesenc... | oligo bathing | Mouse pancreas explants or epithelia |
| Koide T, Downes M, Chandraratna RA, Blumberg B, Umesono K | Genes Dev 2001 Aug 15;15(16):2111-21 | The retinoic acid receptors (RARs) recruit coactivator and corepressor proteins to activate or re... | Active repression of RAR signaling is required for head formation | Microinjection | Xenopus |
| Kos R, Reedy MV, Johnson RL, Erickson CA | Development 2001 128(8):1467-1479 | The winged-helix or forkhead class of transcription factors has been shown to play important role... | The winged-helix transcription factor FoxD3 is important for establishing the neural crest lineag... | Electroporation | chick embryo |
| Kudoh T, Wilson SW, Dawid IB | Development. 2002 Sep;129(18):4335-46 | Early neural patterning in vertebrates involves signals that inhibit anterior (A) and promote pos... | Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectoderm | Microinjection | zebrafish |
| Kuroda H, Inui M, Sugimoto K, Hayata T, Asashima M | Dev Biol. 2002 Apr 15;244(2):267-77 | Prenotochord cell sorting is regarded as one of the first cell sorting events in early chordate d... | Axial protocadherin is a mediator of prenotochord cell sorting in Xenopus | Microinjection | Xenopus |
| Kwak SJ, Phillips BT, Heck R, Riley BB | Development. 2002 Nov 15;129(22):5279-5287 | The valentino (val) mutation in zebrafish perturbs hindbrain patterning and, as a secondary conse... | An expanded domain of fgf3 expression in the hindbrain of zebrafish valentino mutants results in ... | Microinjection | zebrafish |
| Lacerra G, Sierakowska H, Carestia C, Fucharoen S, Summerton J, Weller D, Kole R | Proc Natl Acad Sci U S A 2000 Aug 15;97(17):9591-6 | Mononuclear cells from peripheral blood of thalassemic patients were treated with morpholino olig... | Restoration of hemoglobin A synthesis in erythroid cells from peripheral blood of thalassemic pat... | syringe loading | cell culture: human mononuclear cells |
| Lacroix L, Arimondo PB, Takasugi M, Helene C, Mergny JL | Biochem Biophys Res Commun 2000 Apr 13;270(2):363-9 | Oligonucleotides can be used as sequence-specific DNA ligands by forming a local triple helix. In... | Pyrimidine morpholino oligonucleotides form a stable triple helix in the absence of magnesium ion... | not applicable | not applicable |
| Langheinrich U, Hennen E, Stott G, Vacun G | Curr Biol. 2002 Dec 10;12(23):2023-8 | p53 and its main negative regulator, Mdm2, are key players in mammalian cancer development. Activ... | Zebrafish as a Model Organism for the Identification and Characterization of Drugs and Genes Affe... | Microinjection | zebrafish |
| Lawn R M, David P. Wade, Michael R. Garvin, Xingbo Wang, Karen Schwartz, J. Gordon Porter, Jeffre... | J Clin Invest 1999; 104: R25-R31 | The ABC1 transporter was identified as the defect in Tangier disease by a combined strategy of ge... | The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal... | Scrape Delivery | cell culture: human fibroblasts |
| Lee H, Kimelman D | Dev Cell. 2002 May;2(5):607-16 | Epidermal stem cells play a critical role in producing the multilayered vertebrate skin. Products... | A Dominant-Negative Form of p63 Is Required for Epidermal Proliferation in Zebrafish | Microinjection | zebrafish |
| Lee P, Goishi K, Davidson AJ, Mannix R, Zon L, Klagsbrun M | Proc Natl Acad Sci U S A 2002 Aug 6;99(16):10470-5 | Neuropilin-1 (NRP1) is a cell-surface receptor for both vascular endothelial growth factor(165) (... | Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesi... | Microinjection | zebrafish |
| Lefebvre C, Terret ME, Djiane A, Rassinier P, Maro B, Verlhac MH. | J Cell Biol. 2002 May 13;157(4):603-13 | Vertebrate oocytes arrest in the second metaphase of meiosis (metaphase II [MII]) by an activity ... | Meiotic spindle stability depends on MAPK-interacting and spindle-stabilizing protein (MISS), a n... | Microinjection | mouse oocytes |
| Leger S, Brand M | Mech Dev. 2002 Nov;119(1):91 | The vertebrate inner ear develops from initially 'simple' ectodermal placode and vesicle stages i... | Fgf8 and Fgf3 are required for zebrafish ear placode induction, maintenance and inner ear pattern... | Microinjection | zebrafish |
| Lele Z, Bakkers J, Hammerschmidt M. | Genesis. 2001 Jul;30(3):190-4 | No abstract available. | Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail m... | Microinjection | zebrafish |
| Lemjabbar H, Basbaum C. | Nature Medicine. 2002 Jan;8(1):41-46 | In the lungs of cystic fibrosis patients, overproduction of mucus leads to morbidity and mortalit... | Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epit... | Special Delivery | cell culture: human epithelial cells |
| Lekven AC, Thorpe CJ, Waxman JS, Moon RT | Dev Cell 2001 Jul;1(1):103-14 | In vertebrates, wnt8 has been implicated in the early patterning of the mesoderm. To determine di... | Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm... | Microinjection | zebrafish |
| Lewis KE, Eisen JS | Development. 2001 Sep;128(18):3485-95 | Sonic hedgehog (Shh) is crucial for motoneuron development in chick and mouse. However, zebrafish... | Hedgehog signaling is required for primary motoneuron induction in zebrafish | Microinjection | zebrafish |
| Liu S, Lu W, Obara T, Kuida S, Lehoczky J, Dewar K, Drummond IA, Beier DR | Development. 2002 Dec;129(24):5839-46 | The murine autosomal recessive juvenile cystic kidney (jck) mutation results in polycystic kidney... | A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish | Microinjection | zebrafish |
| Liu G, He J, Zhang S, Liu C, Rusckowski M, Hnatowich DJ | Antisense Nucleic Acid Drug Dev. 2002 Dec;12(6):393-8 | Watson-Crick pairing between complementary oligomers is proving to be an effective means for rapi... | Cytosine residues influence kidney accumulations of 99mTc-labeled morpholino oligomers | In vivo: injection | male CD-1 mice |
| Liu G, Zhang S, He J, Liu N, Gupta S, Rusckowski M, Hnatowich DJ. | Q J Nucl Med. 2002 Sep;46(3):233-43 | BACKGROUND: Despite in vivo use now over several years, in particular for nuclear medicine imagin... | The influence of chain length and base sequence on the pharmacokinetic behavior of 99mTc-morpholi... | | |
| Liu G, Zhang S, He J, Zhu Z, Rusckowski M, Hnatowich DJ | Bioconjug Chem. 2002 Jul 17;13(4):893-897 | S-Acetyl MAG(3) (S-acetylmercaptoacetyltriglycine) has been used as a chelator for the (99m)Tc la... | Improving the Labeling of S-Acetyl NHS-MAG(3)-Conjugated Morpholino Oligomers | not applicable | not applicable |
| Liu G, Mang'era K, Liu N, Gupta S, Rusckowski M, Hnatowich DJ | J Nucl Med. 2002 Mar;43(3):384-391 | Over the past several years, investigators in this laboratory and elsewhere have been studying tu... | Tumor Pretargeting in Mice Using (99m)Tc-Labeled Morpholino, a DNA Analog | In vivo: injection | CD-1 mice |
| Luo T, Lee YH, Saint-Jeannet JP, Sargent TD | Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):532-7. Epub 2003 Jan 02 | We report experiments with Xenopus laevis, using both intact embryos and ectodermal explants, sho... | Induction of neural crest in Xenopus by transcription factor AP2{alpha} | Microinjection | Xenopus |
| Mang'era KO, Liu G, Yi W, Zhang Y, Liu N, Gupta S, Rusckowski M, Hnatowich DJ | Eur J Nucl Med 2001 Nov;28(11):1682-9 | This laboratory is evaluating phosphorothioate deoxyribonucleic acids (DNAs) and peptide nucleic ... | Initial investigations of 99m Tc-labeled morpholinos for radiopharmaceutical applications | not applicable | not applicable |
| Maroon H, Walshe J, Mahmood R, Kiefer P, Dickson C, Mason I | Development. 2002 May 1;129(9):2099-2108 | Fgf3 has long been implicated in otic placode induction and early development of the otocyst; how... | Fgf3 and Fgf8 are required together for formation of the otic placode and vesicle | Microinjection | zebrafish |
| Masumoto J, Zhou W, Chen FF, Su F, Kuwada JY, Hidaka E, Katsuyama T, Sagara J, Taniguchi S, Ngo-H... | J Biol Chem. 2003 Feb 7;278(6):4268-76. Epub 2002 Dec 02. | The pyrin domain was identified recently in multiple proteins that are associated with apoptosis ... | Caspy: A Zebrafish caspase activated by ASC oligomerization required for pharyngeal Arch develop... | Microinjection | zebrafish |
| Maves L, Jackman W, Kimmel CB | Development. 2002. 129(16):3825-3837 | The segmentation of the vertebrate hindbrain into rhombomeres is highly conserved, but how early ... | FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain | Microinjection | zebrafish |
| Mazanet MM, Hughes CC | J Immunol. 2002 Oct 1;169(7):3581-8 | Human endothelial cells (ECs) provide costimulatory signals sufficient to activate resting memory... | B7-h1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis | Special Delivery | cell culture:human endothelial cells (ECs) |
| McClintock JM, Kheirbek MA, Prince VE | Development. 2002 May 15;129(10):2339-2354 | We have used a morpholino-based knockdown approach to investigate the functions of a pair of zebr... | Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and ... | Microinjection | zebrafish |
| McGarry TJ | Mol Biol Cell. 2002 Oct 1; 13(10): 3662-3671 | Geminin is an unstable inhibitor of DNA replication that gets destroyed at the metaphase/anaphase... | Geminin Deficiency Causes a Chk1-dependent G2 Arrest in Xenopus | Microinjection | Xenopus |
| McKeon J, Cho MJ, Khaledi MG | Anal Biochem 2001 Jun 1;293(1):1-7 | Antisense oligonucleotides have shown great promise over the past several years as viable drugs t... | Quantitation of Intracellular Concentration of a Delivered Morpholino Oligomer by Capillary Elect... | Scrape Delivery | cell culture: HeLa AntisenseTest System |
| Mellitzer G, Hallonet M, Chen L, Ang S | Mech Dev. 2002 Oct;118(1-2):57 | Here we report the use of double-stranded RNA (dsRNA) and morpholino technologies to specifically... | Spatial and temporal 'knock down' of gene expression by electroporation of double-stranded RNA an... | Electroporation | Mouse embryo |
| Micklefield J | Curr Med Chem. 2001 Aug;8(10):1157-79. | Nucleic acids have been extensively modified by replacing the phosphodiester group or the whole s... | Backbone Modification of Nucleic Acids: Synthesis, Structure and Therapeutic Applications | not applicable | not applicable |
