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Zebrafish contract research and commercial licenses

For contract research using Morpholinos in zebrafish or to license Morpholinos for commercial use in zebrafish in the USA, contact Zygogen, Inc. See the Outside Resources box for more information.

Publications Database

Publications - Page 6
AuthorsCitationAbstractTitleDelivery MethodOrganism
Willot V, Mathieu J, Lu Y, Schmid B, Sidi S, Yan YL, Postlethwait JH, Mullins M, Rosa F, Peyriera...Dev Biol. 2002 Jan 1;241(1):59-78It was shown in Xenopus and chick that Spemann's organizer activity is regulated through the nega...Cooperative Action of ADMP- and BMP-Mediated Pathways in Regulating Cell Fates in the Zebrafish G...Microinjectionzebrafish
Winklbauer R, Medina A, Swain RK, Steinbeisser HNature. 2001 Oct 25;413(6858):856-60Cell signalling through Frizzled receptors has evolved to considerable complexity within the meta...Frizzled-7 signalling controls tissue separation during Xenopus gastrulationMicroinjectionXenopus
Wright EK, Goodart SA, Growney JD, Hadinoto V, Endrizzi MG, Long EM, Sadigh K, Abney AL, Bernstei...Curr Biol. 2003 Jan 8;13(1):27-36BACKGROUND: Legionella pneumophila is a gram-negative bacterial pathogen that is the cause of Leg...Naip5 Affects Host Susceptibility to the Intracellular Pathogen Legionella pneumophilaSpecial Deliverycell culture: primary macrophages
Yamane K, Wu X, Chen JMol Cell Biol. 2002 Jan 15;22(2):555-66BRCA1 carboxyl-terminal (BRCT) motifs are present in a number of proteins involved in DNA repair ...A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell SurvivalElectroporationcell culture: HeLa cells
Yan Y, Shirakabe K, Werb ZJ Cell Biol. 2002 Jul 15Communication between different signaling pathways enables cells to coordinate the responses to d...The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-...Special Deliverycell culture: PC3 cells
Yan YL, Miller CT, Nissen R, Singer A, Liu D, Kirn A, Draper B, Willoughby J, Morcos PA, Amsterda...Development. 2002 Nov 1;129(21):5065-5079The molecular genetic mechanisms of cartilage construction are incompletely understood. Zebrafish...A zebrafish sox9 gene required for cartilage morphogenesisMicroinjectionzebrafish
Yang Z, Liu N, Lin SDev Biol 2001 Mar 1;231(1):138-148Identification of the earliest forebrain-specific markers should facilitate the elucidation of mo...A Zebrafish Forebrain-Specific Zinc Finger Gene Can Induce Ectopic dlx2 and dlx6 ExpressionMicroinjectionzebrafish
Yee NS, Yusuff S, Pack M.Genesis. 2001 Jul;30(3):137-40.No abstract available.Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, a...Microinjectionzebrafish
Zhao H, Cao Y, Grunz HInt J Dev Biol. 2001 Oct;45(7):817-26We have identified a cDNA coding for a Xenopus MARCKS-like protein (XMLP) from a cDNA library pre...Isolation and characterization of a Xenopus gene (XMLP) encoding a MARCKS-like proteinMicroinjectionXenopus
Zhong TP, Childs S, Leu JP, Fishman MC Nature 2001 Nov 8;414(6860:216-20Arteries and veins are morphologically, functionally and molecularly very different, but how this...Gridlock signalling pathway fashions the first embryonic arteryMicroinjectionzebrafish
Louvet-Vallee S, Kolotuev I, Podbilewicz B, Felix MAGenetics. 2003 Jan;163(1):133-46To compare vulva development mechanisms in the nematode Oscheius sp. 1 to those known in Caenorha...Control of Vulval Competence and Centering in the Nematode Oscheius sp. 1 CEW1Microinjectionnematode
Oelgeschlager M, Kuroda H, Reversade B, De Robertis EMDev Cell. 2003 Feb;4(2):219-30We analyzed the Chordin requirement in Xenopus development. Targeting of both chordin Xenopus lae...Chordin is required for the spemann organizer transplantation phenomenon in Xenopus embryosMicroinjectionXenopus laevis
Hammond KL, Loynes HE, Folarin AA, Smith J, Whitfield TT.Development 2003 Apr 1;130(7):1403-1417Currently, few factors have been identified that provide the inductive signals necessary to trans...Hedgehog signalling is required for correct anteroposterior patterning of the zebrafish otic vesi...Microinjectionzebrafish
Kimmel CB, Ullmann B, Walker M, Miller CT, Crump JG.Development 2003 Apr 1;130(7):1339-1351Endothelin 1 (Edn1), a secreted peptide expressed ventrally in the primordia of the zebrafish pha...Endothelin 1-mediated regulation of pharyngeal bone development in zebrafish.Microinjectionzebrafish
Doitsidou M, Reichman-Fried M, Stebler J, Koprunner M, Dorries J, Meyer D, Esguerra CV, Leung T, ...Cell 2002 Nov 27;111(5):647-59The signals directing primordial germ cell (PGC) migration in vertebrates are largely unknown. We...Guidance of Primordial Germ Cell Migration by the Chemokine SDF-1Microinjectionzebrafish
Lekven AC, Buckles GR, Kostakis N, Moon RTDev Biol 2003 Feb 15;254(2):172-87Wnt signals have been shown to be involved in multiple steps of vertebrate neural patterning, yet...Wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundary.Microinjectionzebrafish
Clements D, Cameleyre I, Woodland HRMech Dev 2003 Mar;120(3):337-48We have used antisense morpholino oligos to establish the developmental roles of three Xsox17 pro...Redundant early and overlapping larval roles of Xsox17 subgroup genes in Xenopus endoderm develop...MicroinjectionXenopus
Sidi S, Goutel C, Peyrieras N, Rosa FMProc Natl Acad Sci U S A 2003 Feb 24; [epub ahead of print]- get citation 100(6):3315-3320In vertebrate embryos, maternal determinants are thought to preestablish the dorsoventral axis by...Maternal induction of ventral fate by zebrafish radarMicroinjectionzebrafish
Mogi K, Gogo M, Ohno E, Azumi Y, Takeuchi S, Toyoizumi RInt J Dev Biol 2003 47:15-29A variety of TGF-b-related ligands regulate the left-right asymmetry of vertebrates but the invol...Xenopus neurula left-right asymmetry is respeficied by microinjecting TGF-b5 proteinMicroinjectionXenopus laevis
Kanungo J, Kozmik Z, Swamynathan SK, Piatigorsky JProc Natl Acad Sci U S A. 2003 Mar 18;100(6):3287-92The gene for gelsolin (an actin-binding, cytoskeletal regulatory protein) was shown earlier to be...Gelsolin is a dorsalizing factor in zebrafishMicroinjectionzebrafish
Yahiro K, Wada A, Nakayama M, Kimura T, Ogushi KI, Niidome T, Aoyagi H, Yoshino KI, Yonezawa K, M...J Biol Chem. 2003 May 23;278(21):19183-9. Epub 2003 Mar 06Helicobacter pylori vacuolating cytotoxin, VacA, induces vacuolation, mitochondrial damage, cytoc...Protein tyrosine phosphatase a, RPTPa, is a helicobacter pylori VacA receptorSpecial Deliverycell culture: G401, Wilms' human kidney tumor cells
Geling A, Itoh M, Tallafuss A, Chapouton P, Tannhauser B, Kuwada JY, Chitnis AB, Bally-Cuif LDevelopment 2003 Apr 15;130(8):1591-1604The midbrain-hindbrain (MH) domain of the vertebrate embryonic neural plate displays a stereotypi...bHLH transcription factor Her5 links patterning to regional inhibition of neurogenesis at the mid...Microinjectionzebrafish
Karlstrom RO, Tyurina OV, Kawakami A, Nishioka N, Talbot WS, Sasaki H, Schier AFDevelopment 2003 Apr 15;130(8):1549-1564Gli proteins regulate the transcription of Hedgehog (Hh) target genes. Genetic studies in mouse h...Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in verte...Microinjectionzebrafish
Guyon JR, Mosley AN, Zhou Y, O'Brien KF, Sheng X, Chiang K, Davidson AJ, Volinski JM, Zon LI, Kun...Hum Mol Genet 2003 Mar 15;12(6):601-15Many cases of muscular dystrophy in humans are caused by mutations in members of the dystrophin a...The dystrophin associated protein complex in zebrafishMicroinjectionzebrafish
Kos R, Tucker RP, Hall R, Duong TD, Erickson CADev Dyn 2003 Mar;226(3):470-7The use of antisense morpholino oligos to inhibit the translation of a target transcript has been...Methods for introducing morpholinos into the chicken embryoElectroporationchick embryo
Liu C, Liu G, Liu N, Zhang YM, He J, Rusckowski M, Hnatowich DJNucl Med Biol 2003 Feb;30(2):207-14This laboratory is investigating morpholinos (MORF), a DNA analogue, for radiopharmaceutical appl...Radiolabeling morpholinos with (90)Y, (111)In, (188)Re and (99m)Tcin vivo: injectionmale CD-1 mice
Oates AC, Ho RKDevelopment 2002 Jun;129(12):2929-46We have examined the expression of a Hairy/E(spl)-related (Her) gene, her7, in the zebrafish and ...Hairy/E(spl)-related (Her) genes are central components of the segmentation oscillator and displa...Microinjectionzebrafish
Hsu HJ, Lin G, Chung BCDevelopment 2003 May;130(10):2107-16Steroids are synthesized mainly from the adrenal cortex. Adrenal deficiencies are often associate...Parallel early development of zebrafish interrenal glands and pronephros: differential control by...Microinjectionzebrafish
Cau E, Wilson SWDevelopment 2003 Jun;130(11):2455-66The homeodomain transcription factor Floating head (Flh) is required for the generation of neuron...Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesisMicroinjectionzebrafish
Long S, Ahmad N, Rebagliati MDevelopment 2003 Jun;130(11):2303-16We have identified and characterized a new zebrafish gene, southpaw, that is required for viscera...The zebrafish nodal-related gene southpaw is required for visceral and diencephalic left-right as...Microinjectionzebrafish
Kramer KL, Yost HJDev Cell 2002 Jan;2(1):115-24Heparan sulfate proteoglycans expressed on the Xenopus animal cap ectoderm have been implicated i...Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonauton...MicroinjectionXenopus
Rottbauer W, Saurin AJ, Lickert H, Shen X, Burns CG, Wo ZG, Kemler R, Kingston R, Wu C, Fishman MCell 2002 Nov 27;111(5):661-72Organ size is precisely regulated during development, but the control mechanisms remain obscure. ...Reptin and pontin antagonistically regulate heart growth in zebrafish embryosMicroinjectionzebrafish
Seo H, Hong SJ, Guo S, Kim HS, Kim CH, Hwang DY, Isacson O, Rosenthal A, Kim KSJ Neurochem 2002 Mar;80(5):905-16Development of noraderenergic (NA) neurons in the vertebrate brain is dependent on the homeodomai...A direct role of the homeodomain proteins Phox2a/2b in noradrenaline neurotransmitter identity de...Microinjectionzebrafish
Yamashita S, Miyagi C, Carmany-Rampey A, Shimizu T, Fujii R, Schier AF, HiranoDev Cell 2002 Mar;2(3):363-75Vertebrate axis formation requires both the correct specification of cell fates and the coordinat...Stat3 Controls Cell Movements during Zebrafish GastrulationMicroinjectionzebrafish
Knaut H, Werz C, Geisler R, Nusslein-Volhard C; Tubingen 2000 Screen ConsortiumNature 2003 Jan 16;421(6920):279-82Germ cells preserve an individual's genetic information and transmit it to the next generation. E...A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptorMicroinjectionzebrafish
Marlow F, Topczewski J, Sepich D, Solnica-Krezel LCurr Biol 2002 Jun 4;12(11):876-84BACKGROUND: During vertebrate gastrulation convergence and extension (CE), movements narrow and l...Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergenc...Microinjectionzebrafish
Nisoli E, Clementi E, Paolucci C, Cozzi V, Tonello C, Sciorati C, Bracale R, Valerio A, Francolin...Science 2003 Feb 7;299(5608):896-9Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown adipocyte...Mitochondrial biogenesis in mammals: the role of endogenous nitric oxideSpecial Deliverycell culture: mouse brown adipocytes
Yabe S, Tanegashima K, Haramoto Y, Takahashi S, Fujii T, Kozuma S, Taketani Y, Asashima MDevelopment 2003 May 15;130(10):2071-2081Recent studies indicate an essential role for the EGF-CFC family in vertebrate development, parti...FRL-1, a member of the EGF-CFC family, is essential for neural differentiation in Xenopus early d...MicroinjectionXenopus
Lampert JM, Holzschuh J, Hessel S, Driever W, Vogt K, Von Lintig JDevelopment 2003 May;130(10):2173-86The egg yolk of vertebrates contains carotenoids, which account for its characteristic yellow col...Provitamin A conversion to retinal via the beta,beta-carotene-15,15'-oxygenase (bcox) is essentia...Microinjectionzebrafish
Furthauer M, Lin W, Ang SL, Thisse B, Thisse CNat Cell Biol 2002 Feb;4(2):170-4Fibroblast growth factors (FGFs) are pleiotrophic growth factors that control cell proliferation,...Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signallingMicroinjectionzebrafish
Yamamoto T, Yao Y, Harumi T, Suzuki N Zoolog Sci 2003;20(2):181-91To better understand the nitric oxide (NO) / cyclic GMP (cGMP) signaling pathway during embryogen...Localization of the Nitric Oxide/cGMP Signaling Pathway-Related Genes and Influences of Morpholin...Microinjectionmedaka embryos
Hall RJ, Erickson CADev Biol 2003 Apr 1;256(1):147-60The ADAMs are a family of proteins containing multiple functional domains. We have cloned the avi...ADAM 10: an active metalloprotease expressed during avian epithelial morphogenesis.pluronic gelchick embryo
Takayama Y, Takahashi H, Mizumachi K, Takezawa TJ Biol Chem. 2003 Jun 13;278(24):22112-8. Epub 2003 Apr 01Fibroblasts plated on a type I collagen gel can reduce the size of the gel in a way that mimics t...Low-density lipoprotein receptor-related protein (LRP) is required for lactoferrin-enhanced colla...Special Deliverycell culture: WI-38 human fetal fibroblasts
Braasch DA, Corey DRBiochemistry 2002 Apr 9;41(14):4503-10Antisense oligonucleotides have the potential to make revolutionary contributions to basic scienc...Novel antisense and peptide nucleic acid strategies for controlling gene expressionnot applicablenot applicable
Wu CF, Chan AP, Etkin LDDev Biol 2003 Mar 15;255(2):290-302Tumorhead (TH) is a maternally expressed gene in Xenopus laevis, that when overexpressed, increas...Difference in the maternal and zygotic contributions of tumorhead on embryogenesis.MicroinjectionXenopus
Wu J, Saint-Jeannet JP, Klein PSTrends Neurosci 2003 Jan;26(1):40-5No abstract available.Wnt-frizzled signaling in neural crest formation.MicroinjectionXenopus
Kramer KL, Barnette JE, Yost HJCell 2002 Dec 27;111(7):981-90The transmembrane proteoglycan syndecan-2 cell nonautonomously regulates left-right (LR) developm...PKCgamma regulates syndecan-2 inside-out signaling during xenopus left-right development.MicroinjectionXenopus
Osada S, Ohmori SY, Taira M.Development 2003 May;130(9):1783-94A family of inner nuclear membrane proteins is implicated in gene regulation by interacting with ...XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 in ...MicroinjectionXenopus
Bae YK, Shimizu T, Yabe T, Kim CH, Hirata T, Nojima H, Muraoka O, Hirano T, Hibi M.Development 2003 May;130(9):1853-65A homeobox gene, pnx, is expressed in prospective posterior neurogenic regions and later in prima...A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish.Microinjectionzebrafish
Heggem MA, Bradley RS.Dev Cell 2003 Mar;4(3):419-29Protocadherins are members of the cadherin superfamily of cell adhesion molecules proposed to pla...The cytoplasmic domain of Xenopus NF-protocadherin interacts with TAF1/set.MicroinjectionXenopus

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