Publications - Page 68
| Authors | Citation | Abstract | Title | Delivery Method | Organism |
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| Sallinen V, Kolehmainen J, Priyadarshini M, Toleikyte G, Chen YC, Panula P | Neurobiol Dis. 2010 Jun 18. [Epub ahead of print] | The functions of PTEN (phosphatase/tensin homolog)-induced putative kinase (PINK1), which is muta... | Dopaminergic cell damage and vulnerability to MPTP in Pink1 knockdown zebrafish | | zebrafish |
| Clark BW, Matson CW, Jung D, Di Giulio RT | Aquat Toxicol. 2010 Aug 15;99(2):232-40 | Exposure of developing fish to polycyclic aromatic hydrocarbons (PAHs) and halogenated aromatic h... | AHR2 mediates cardiac teratogenesis of polycyclic aromatic hydrocarbons and PCB-126 in Atlantic k... | | Fundulus heteroclitus |
| Zhong H, Xin S, Zhao Y, Lu J, Li S, Gong J, Yang Z, Lin S | Mol Biosyst. 2010 Aug;6(8):1463-8. Epub 2010 May 19 | During the preclinical drug discovery process it remains a challenge to enable early elimination ... | Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using ... | | zebrafish |
| Hermans K, Claes F, Vandevelde W, Zheng W, Geudens I, Orsenigo F, De Smet F, Gjini E, Anthonis K,... | Blood. 2010 Jul 14. [Epub ahead of print] | The molecular basis of lymphangiogenesis remains incompletely characterized. Here, we document a ... | Role of synectin in lymphatic development in zebrafish and frogs | | Xenopus and zebrafish |
| Whitley DS, Yu K, Sample RC, Sinning A, Henegar J, Norcross E, Chinchar VG | Virology. 2010 Jul 13. [Epub ahead of print] | Although previous work identified 12 complementation groups with possible roles in virus assembly... | Frog virus 3 ORF 53R, a putative myristoylated membrane protein, is essential for virus replicati... | | Frog virus 3 in cultured cells |
| Doherty JT, Conlon FL, Mack CP, Taylor JM | Genesis. 2010 Jun 22. [Epub ahead of print] | Focal adhesion kinase (FAK) is a critical mediator of matrix- and growth factor-induced signaling... | Focal adhesion kinase is essential for cardiac looping and multi-chamber heart formation | | Xenopus laevis |
| Zhao X, Zhao L, Tian T, Zhang Y, Tong J, Zheng X, Meng A | J Biol Chem. 2010 Jun 23. [Epub ahead of print] | Kinetochore proteins associate with centromeric DNA and spindle microtubules and play essential r... | Interruption of cenph causes mitotic failure and embryonic death and its haploinsufficiency suppr... | | zebrafish |
| Zhang J, Wagh P, Guay D, Sanchez-Pulido L, Padhi BK, Korzh V, Andrade-Navarro MA, Akimenko MA | Nature. 2010 Jul 8;466(7303):234-7. Epub 2010 Jun 23 | The early development of teleost paired fins is strikingly similar to that of tetrapod limb buds ... | Loss of fish actinotrichia proteins and the fin-to-limb transition | | zebrafish |
| Talbot JC, Johnson SL, Kimmel CB | Development. 2010 Aug 1;137(15):2507-17. Epub 2010 Jun 23 | The ventrally expressed secreted polypeptide endothelin1 (Edn1) patterns the skeleton derived fro... | hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal ... | Microinjection | zebrafish |
| Vera T, Stec DE | Am J Physiol Regul Integr Comp Physiol. 2010 Jul 28. [Epub ahead of print] | We have previously demonstrated that moderate hyperbilirubinemia decreases blood pressure in Angi... | Moderate Hyperbilirubinemia Improves Renal Hemodynamics in Angiotensin II Dependent Hypertension | Vivo-Morpholino | mice C57BL/6J |
| Hines JH, Abu-Rub M, Henley JR | Nat Neurosci. 2010 Jul;13(7):829-37. Epub 2010 May 30 | Gradients of chemorepellent factors released from myelin may impair axon pathfinding and neuroreg... | Asymmetric endocytosis and remodeling of beta1-integrin adhesions during growth cone chemorepulsi... | Microinjection | Xenopus |
| Stephens WZ, Senecal M, Nguyen M, Piotrowski T | Dev Dyn. 2010 Jul;239(7):2066-77 | The distal region of neural retina (ciliary marginal zone [CMZ]) contains stem cells that produce... | Loss of adenomatous polyposis coli (apc) results in an expanded ciliary marginal zone in the zebr... | | zebrafish |
| Panáková D, Werdich AA, Macrae CA | Nature. 2010 Jul 25. [Epub ahead of print] | Electrical gradients are critical for many biological processes, including the normal function of... | Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel | | zebrafish |
| Qi HH, Sarkissian M, Hu GQ, Wang Z, Bhattacharjee A, Gordon DB, Gonzales M, Lan F, Ongusaha PP, H... | Nature. 2010 Jul 22;466(7305):503-7. Epub 2010 Jul 11 | X-linked mental retardation (XLMR) is a complex human disease that causes intellectual disability... | Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development | | zebrafish |
| Kim SH, Choi HY, So JH, Kim CH, Ho SY, Frank M, Li Q, Uitto J | Matrix Biol. 2010 Jul 26. [Epub ahead of print] | The human COL17A1 gene encodes type XVII collagen (also known as the 180-kDa bullous pemphigoid a... | Zebrafish type XVII collagen: Gene structures, expression profiles, and morpholino "knock-down" p... | | zebrafish |
| Froger A, Clemens DM, Kalman K, Németh-Cahalan KL, Schilling TF, Hall JE | Invest Ophthalmol Vis Sci. 2010 Jul 29. [Epub ahead of print] | Purpose: AQP0, formerly known as MIP26, likely has multiple separate functions in the mammalian l... | Two Distinct Aquaporin 0s are Required for Development and Transparency of the Zebrafish Lens | Microinjection | zebrafish |
| Sobieszczuk DF, Poliakov A, Xu Q, Wilkinson DG | Genes Dev. 2010 Jan 15;24(2):206-18 | Neuronal differentiation is regulated by proneural genes that promote neurogenesis and inhibitory... | A feedback loop mediated by degradation of an inhibitor is required to initiate neuronal differen... | Microinjection | zebrafish |
| Peng JC, Valouev A, Swigut T, Zhang J, Zhao Y, Sidow A, Wysocka J | Cell. 2009 Dec 24;139(7):1290-302 | Polycomb Repressive Complex 2 (PRC2) regulates key developmental genes in embryonic stem (ES) cel... | Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in plurip... | Microinjection | Xenopus laevis |
| Isenberg JS, Shiva S, Gladwin M | Nitric Oxide. 2009 Aug;21(1):52-62. Epub 2009 May 27 | Tissue ischemia and ischemia-reperfusion (I/R) remain sources of cell and tissue death. Inability... | Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow... | Injection | C57BL/6 male mice |
| Clendenon SG, Shah B, Miller CA, Schmeisser G, Walter A, Gattone VH 2nd, Barald KF, Liu Q, Marrs ... | Dev Dyn. 2009 Aug;238(8):1909-22 | Cadherin-11/Cdh11 is expressed through early development and strongly during inner ear developmen... | Cadherin-11 controls otolith assembly: evidence for extracellular cadherin activity | Microinjection | zebrafish |
| Ossipova O, Ezan J, Sokol SY | Dev Cell. 2009 Aug;17(2):222-33 | Generation of neurons in the vertebrate central nervous system requires a complex transcriptional... | PAR-1 phosphorylates Mind bomb to promote vertebrate neurogenesis | Microinjection | Xenopus |
| Nilsson R, Schultz IJ, Pierce EL, Soltis KA, Naranuntarat A, Ward DM, Baughman JM, Paradkar PN, K... | Cell Metab. 2009 Aug;10(2):119-30 | Heme biosynthesis consists of a series of eight enzymatic reactions that originate in mitochondri... | Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis | Microinjection | zebrafish |
| Peng K, Li Y, Long L, Li D, Jia Q, Wang Y, Shen Q, Tang Y, Wen L, Kung HF, Peng Y | Neurosci Lett. 2010 Jul 29. [Epub ahead of print] | Neuronal apoptosis sculpts the developing brain, and nearly all identified classes of neurons see... | Knockdown of FoxO3a induces increased neuronal apoptosis during embryonic development in zebrafis... | | zebrafish |
| Katow H, Suyemitsu T, Ooka S, Yaguchi J, Jin-Nai T, Kuwahara I, Katow T, Yaguchi S, Abe H | J Exp Biol. 2010 Aug 15;213(Pt 16):2808-19 | The mechanisms that regulate the organized swimming movements of sea urchin blastulae are largely... | Development of a dopaminergic system in sea urchin embryos and larvae | | Sea urchin, Hemicentrotus pulcherrimus |
| Gwak JW, Kong HJ, Bae YK, Kim MJ, Lee J, Park JH, Yeo SY | Mol Cells. 2010 Jul 23. [Epub ahead of print] | In the central nervous system (CNS), giving rise to the diversity and the complexity of neurons i... | Proliferating neural progenitors in the developing CNS of zebrafish require Jagged2 and Jagged1b | Microinjection | zebrafish |
| Marek KW, Kurtz LM, Spitzer NC | Nat Neurosci. 2010 Aug;13(8):944-50. Epub 2010 Jun 27 | Neuronal differentiation is accomplished through cascades of intrinsic genetic factors initiated ... | cJun integrates calcium activity and tlx3 expression to regulate neurotransmitter specification | Microinjection | Xenopus tropicalis |
| Tercero N, Wang K, Levicky R | Langmuir. 2010 Aug 9. [Epub ahead of print] | Impedance and cyclic voltammetry methods, complemented by Poisson-Boltzmann (PB) modeling, are us... | Capacitive Monitoring of Morpholino-DNA Surface Hybridization: Experimental and Theoretical Analy... | | |
| Tazumi S, Yabe S, Uchiyama H | Dev Biol. 2010 Aug 5. [Epub ahead of print] | We previously reported that Tbx6, a T-box transcription factor, is required for the differentiati... | Paraxial T-box genes, Tbx6 and Tbx1, are required for cranial chondrogenesis and myogenesis | | zebrafish |
| Fung TK, Chung MI, Liang R, Leung AY | Exp Hematol. 2010 Aug 6. [Epub ahead of print] | OBJECTIVE: The nucleoporin NUP98 is a component of the nuclear pore complex which regulates nucle... | The role of a novel zebrafish nup98 during embryonic development | Microinjection | zebrafish |
| Yin H, Moulton HM, Betts C, Merritt T, Seow Y, Ashraf S, Wang Q, Boutilier J, Wood MJ | Mol Ther. 2010 Aug 10. [Epub ahead of print] | Splice modulation using antisense oligonucleotides (AOs) has been shown to yield targeted exon ex... | Functional Rescue of Dystrophin-deficient mdx Mice by a Chimeric Peptide-PMO | i.v. injection | mice, mdx |
| Rikin A, Rosenfeld GE, McCartin K, Evans T | JoVE. 2010;42. http://www.jove.com/index/details.stp?id=2020, doi: 10.3791/2020 | Gene function during embryogenesis is typically defined by loss-of-function experiments, for exam... | A Reverse Genetic Approach to Test Functional Redundancy During Embryogenesis | Microinjection | zebrafish |
| Sims K Jr, Eble DM, Iovine MK | Dev Biol. 2009 Mar 15;327(2):410-8. Epub 2008 Dec 30 | Joints are essential for skeletal form and function, yet their development remains poorly underst... | Connexin43 regulates joint location in zebrafish fins | Injection then electroporation in vivo | zebrafish |
| Bollo M, Paredes RM, Holstein D, Zheleznova N, Camacho P, Lechleiter JD | PLoS One. 2010 Aug 5;5(8). pii: e11925 | The accumulation of misfolded proteins within the endoplasmic reticulum (ER) triggers a cellular ... | Calcineurin Interacts with PERK and Dephosphorylates Calnexin to Relieve ER Stress in Mammals and... | Microinjection | Xenopus laevis |
| Demarque M, Spitzer NC | Neuron. 2010 Jul 29;67(2):321-34 | Genetic programs, environmental factors, and electrical activity interact to drive the maturation... | Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating... | Microinjection | Xenopus laevis |
| Cheng D, Wang Y, Liu X, Pretorius PH, Liang M, Rusckowski M, Hnatowich DJ | Bioconjug Chem. 2010 Aug 3. [Epub ahead of print] | Our objective was to compare the performance of a micro-single photon emission computed tomograph... | Comparison of (18)F PET and (99m)Tc SPECT Imaging in Phantoms and in Tumored Mice | | mice |
| Tsai TC, Lin W, Yang SH, Cheng WT, Cheng EH, Lee MS, Chong KY, Chen CM | BMC Dev Biol. 2010 Aug 12;10(1):88. [Epub ahead of print] | ABSTRACT: BACKGROUND: Detailed knowledge of the molecular and cellular mechanisms that direct spa... | Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygot... | Microinjection | Mouse embryo |
| Del Toro R, Prahst C, Mathivet T, Siegfried G, Kaminker JS, Larrivee B, Breant C, Duarte A, Takak... | Blood. 2010 Aug 12. [Epub ahead of print] | Sprouting of developing blood vessels is mediated by specialized motile endothelial cells localiz... | Identification and functional analysis of endothelial tip cell-enriched genes | | zebrafish |
| Kanungo J, Zheng YL, Amin ND, Kaur S, Ramchandran R, Pant HC | Biochem Biophys Res Commun. 2009 Aug 14;386(1):263-7. Epub 2009 Jun 11 | Cyclin-dependent kinase 5 (cdk5) is a ubiquitous protein activated by specific activators, p35 an... | Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in viv... | Microinjection | zebrafish |
| Khadka DK, Liu W, Habas R | Dev Biol. 2009 Aug 15;332(2):396-406. Epub 2009 Jun 11 | Gastrulation is a critical morphogenetic event during vertebrate embryogenesis, and it is compris... | Non-redundant roles for Profilin2 and Profilin1 during vertebrate gastrulation | Microinjection | Xenopus |
| Liu Y, Li M, Fan S, Lin Y, Lin B, Luo F, Zhang C, Chen S, Li Y, Xu A | J Immunol. 2010 Aug 11. [Epub ahead of print] | MyD88 and Toll/IL-1R domain-containing adaptor protein (TIRAP) are required for the TLR4 response... | A Unique Feature of Toll/IL-1 Receptor Domain-Containing Adaptor Protein Is Partially Responsible... | Microinjection | zebrafish |
| Yaguchi S, Yaguchi J, Angerer RC, Angerer LM, Burke RD | Dev Biol. 2010 Aug 12. [Epub ahead of print] | The ciliary band is a distinct region of embryonic ectoderm that is specified between oral and ab... | TGFbeta signaling positions the ciliary band and patterns neurons in the sea urchin embryo | | sea urchin |
| Conte I, Carrella S, Avellino R, Karali M, Marco-Ferreres R, Bovolenta P, Banfi S | Proc Natl Acad Sci U S A. 2010 Aug 16. [Epub ahead of print] | MicroRNAs (miRNAs) are small noncoding RNAs that have important roles in the regulation of gene e... | miR-204 is required for lens and retinal development via Meis2 targeting | Microinjection | medaka |
| Ishizaki H, Spitzer M, Wildenhain J, Anastasaki C, Zeng Z, Dolma S, Shaw M, Madsen E, Gitlin J, M... | Dis Model Mech. 2010 Aug 16. [Epub ahead of print] | Hypopigmentation is a feature of copper deficiency in humans, as caused by mutation of the copper... | Combined zebrafish-yeast chemical-genetic screens reveal gene-copper-nutrition interactions that ... | Microinjection | zebrafish |
| Macho Sanchez-Simon F, Zhang X, Loh HH, Law PY, Rodriguez RE | Mol Pharmacol. 2010 Aug 17. [Epub ahead of print] | Morphine is one of the most used analgesics to treat chronic pain, although its long-term adminis... | Morphine regulates dopaminergic neuron differentiation via miR-133b | | zebrafish |
| Saito T, Nakamura A, Aoki Y, Yokota T, Okada T, Osawa M, Takeda S | PLoS ONE. 2010 Aug;5(8):e12239. doi:10.1371/journal.pone.0012239 | Background
Antisense oligonucleotide-induced exon skipping is a promising approach for treatment... | Antisense PMO Found in Dystrophic Dog Model Was Effective in Cells from Exon 7-Deleted DMD Patien... | Endo-Porter | cell culture: dog and human |
| Tran HT, Sekkali B, Van Imschoot G, Janssens S, Vleminckx K | Proc Natl Acad Sci U S A. 2010 Aug 30. [Epub ahead of print] | The formation of primitive (embryonic) blood in vertebrates is mediated by spatio-temporally rest... | Wnt/beta-catenin signaling is involved in the induction and maintenance of primitive hematopoies... | | Xenopus |
| Warren TK, Warfield KL, Wells J, Swenson DL, Donner KS, Van Tongeren SA, Garza NL, Dong L, Mouric... | Nat Med. 2010 Aug 22. [Epub ahead of print] | Currently, no vaccines or therapeutics are licensed to counter Ebola or Marburg viruses, highly p... | Advanced antisense therapies for postexposure protection against lethal filovirus infections | Injection | monkey: rhesus, cynomolgus |
| Hurd T, Zhou W, Jenkins P, Liu CJ, Swaroop A, Khanna H, Martens J, Hildebrandt F, Margolis B | Hum Mol Genet. 2010 Aug 20. [Epub ahead of print] | Ciliopathies represent a growing group of human genetic diseases whose etiology lies in defects i... | The Retinitis Pigmentosa Protein RP2 Interacts With Polycystin 2 and Regulates Cilia-Mediated Ver... | | zebrafish |
| Edel MJ, Boué S, Menchon C, Sánchez-Danés A, Belmonte JC | Cell Cycle. 2010 Sep 11;9(17). [Epub ahead of print] | We have recently found that Rem2 GTPase, highly expressed in human embryonic stem cells (hESC), m... | Rem2 GTPase controls proliferation and apoptosis of neurons during embryo development | | zebrafish |
| Phennicie RT, Sullivan MJ, Singer JT, Yoder JA, Kim CH | Infect Immun. 2010 Aug 23. [Epub ahead of print] | Cystic fibrosis (CF) is a genetic disease caused by recessive mutations in the cystic fibrosis tr... | Specific Resistance to Pseudomonas aeruginosa Infection in Zebrafish is Mediated by the Cystic Fi... | | zebrafish |
