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Morpholino Publications Database

Publications - Page 12
AuthorsCitationAbstractTitleDelivery MethodOrganism
Ren C-G, Wang L, Jia X-E, Liu Y-J, Dong J-W, Jin Y, Chen Y, Deng M, Zhou Y, Zhou Y, Ren R-B, Pan ...J Hematol Oncol. 2013;6:34 doi:10.1186/1756-8722-6-34Background The aberrant activation of Ras signaling is associated with human diseases including ...Activated N-Ras signaling regulates arterial-venous specification in zebrafishMicroinjectionzebrafish
Jackman WR, Yoo JJ, Stock DWBMC Developmental Biology 2010, 10:119 doi:10.1186/1471-213X-10-119Background The accessibility of the developing zebrafish pharyngeal dentition makes it an advant...Hedgehog signaling is required at multiple stages of zebrafish tooth developmentMicroinjectionzebrafish
O'Donnell EF, Saili KS, Koch DC, Kopparapu PR, Farrer D, Bisson WH, Mathew LK, Sengupta S, Kerkvl...PLoS ONE. 2010;5(10):e13128. doi:10.1371/journal.pone.0013128Background The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that m...The Anti-Inflammatory Drug Leflunomide Is an Agonist of the Aryl Hydrocarbon ReceptorMicroinjectionzebrafish
Margolin DH, Kousi M, Chan Y-M, Lim ET, Schmahmann JD, Hadjivassiliou M, Hall JE, Adam I, Dwyer A...N Engl J Med. 2013;[Epub ahead of print] doi:10.1056/NEJMoa1215993Background The combination of ataxia and hypogonadism was first described more than a century ag...Ataxia, Dementia, and Hypogonadotropism Caused by Disordered UbiquitinationMicroinjectionzebrafish
Goonesinghe A, Luan XM, Hurlstone A, Garrod DBMC Dev Biol. 2012;12:1 doi:10.1186/1471-213X-12-1Background The desmosomal cadherins (DCs), desmocollin (Dsc) and desmoglein (Dsg), are the adhes...Desmosomal cadherins in zebrafish epiboly and gastrulationMicroinjectionzebrafish
Chiu CH, Chou CW, Takada S, Liu YWPLoS ONE. 2012;7(8):e43040. doi:10.1371/journal.pone.0043040Background The early morphogenetic steps of zebrafish interrenal tissue, the teleostean counterp...Development and Fibronectin Signaling Requirements of the Zebrafish Interrenal VesselMicroinjectionzebrafish
Nestorov P, Battke F, Levesque MP, Gerberding MPLoS ONE. 2013;8(2):e56049. doi:10.1371/journal.pone.0056049Background The embryo of the crustacean Parhyale hawaiensis has a total, unequal and invariant e...The Maternal Transcriptome of the Crustacean Parhyale hawaiensis Is Inherited Asymmetrically to I...MicroinjectionParhyale hawaiensis
Prasad MK, Reed X, Gorkin DU, Cronin JC, McAdow AR, Chain K, Hodonsky CJ, Jones EA, Svaren JP, An...BMC Developmental Biology. 2011;11:40 doi:10.1186/1471-213X-11-40Background The ERBB3 gene is essential for the proper development of the neural crest (NC) and i...SOX10 directly modulates ERBB3 transcription via an intronic neural crest enhancerzebrafish
Tao S, Witte M, Bryson-Richardson RJ, Currie PD, Hogan BM, Schulte-Merker SPLoS ONE. 2011;6(12):e28934. doi:10.1371/journal.pone.0028934Background The expression of the Prospero homeodomain transcription factor (Prox1) in a subset o...Zebrafish prox1b Mutants Develop a Lymphatic Vasculature, and prox1b Does Not Specifically Mark L...Microinjectionzebrafish
Petridou NI, Stylianou P, Christodoulou N, Rhoads D, Guan JL, Skourides PAPLoS One. 2012;7(8):e42577. Epub 2012 Aug 6Background The Focal Adhesion Kinase is a well studied tyrosine kinase involved in a wide number...Activation of Endogenous FAK via Expression of Its Amino Terminal Domain in Xenopus EmbryosMicroinjectionXenopus laevis
Shieh JTC, Huang Y, Gilmore J, Srivastava DPLoS ONE. 2011;6(5):e19481. doi:10.1371/journal.pone.0019481Background The heart responds to myriad stresses by well-described transcriptional responses tha...Elevated miR-499 Levels Blunt the Cardiac Stress ResponseElectroporation (Amaxa)cell culture: ventricular cardiomyocyte line H9c2
Ribeiro CMS, Bird S, Raes G, Ghassabeh GH, Schijns VEJC, Pontes MJSL, Savelkoul HFJ, Wiegertjes G...PLoS ONE. 2011;6(1): e15986. doi:10.1371/journal.pone.0015986Background The innate immune system relies upon a wide range of germ-line encoded receptors incl...A Novel Soluble Immune-Type Receptor (SITR) in Teleost Fish: Carp SITR Is Involved in the Nitric ...Endo-Portercell culture: primary carp macrophages
Giacco LD, Pistocchi A, Ghilardi APLoS ONE. 2010;5(10):e13170. doi:10.1371/journal.pone.0013170Background The lymphatic vascular system, draining interstitial fluids from most tissues and org...prox1b Activity Is Essential in Zebrafish LymphangiogenesisMicroinjectionzebrafish
McCauley BS, Wright EP, Exner CE, Kitazawa C, Hinman VFEvoDevo. 2012;3:17 doi:10.1186/2041-9139-3-17Background The mechanisms by which the conserved genetic “toolkit” for development generates phe...Development of an embryonic skeletogenic mesenchyme lineage in a sea cucumber reveals the traject...Microinjectionsea cucumber, Parastichopus parvimensis
Rouleau M, Saxena V, Rodrigue A, Paquet ER, Gagnon A, Hendzel MJ, Masson J-Y, Ekker M, Poirier GGPLoS ONE. 2011;6(1):e15834. doi:10.1371/journal.pone.0015834Background The PARP family member poly(ADP-ribose) polymerase 3 (PARP3) is structurally related ...A Key Role for Poly(ADP-Ribose) Polymerase 3 in Ectodermal Specification and Neural Crest Develop...Microinjectionzebrafish
Rohani N, Canty L, Luu O, Fagotto F, Winklbauer RPLoS Biol. 2011;9(3):e1000597. doi:10.1371/journal.pbio.1000597Background The primordial organization of the metazoan body is achieved during gastrulation by t...EphrinB/EphB Signaling Controls Embryonic Germ Layer Separation by Contact-Induced Cell Detachmen...MicroinjectionXenopus
Nourizadeh-Lillabadi R, Seilø Torgersen J, Vestrheim O, König M, Aleström P, Syed MPLoS ONE. 2010;5(10):e13573. doi:10.1371/journal.pone.0013573Background The Prion protein (PRNP/Prp) plays a crucial role in transmissible spongiform encepha...Early Embryonic Gene Expression Profiling of Zebrafish Prion Protein (Prp2) MorphantsMicroinjectionzebrafish
Lu J, Tsai T, Choo S, Yeh S, Tang R, Yang A, Lee H, Lu JJ Biomed Sci. 2011;18:73 doi:10.1186/1423-0127-18-73Background The tbx5 mutation in human causes Holt-Oram syndrome, an autosomal dominant condition...Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogen...Microinjectionzebrafish
Huang X, Hui MNY, Liu Y, Yuen DSH, Zhang Y, Chan WY, Lin HR, Cheng SH, Cheng CHKPLoS ONE. 2009;4(7):e6163Background The three pituitary hormones, viz. prolactin (PRL), growth hormone (GH) and somatolac...Discovery of a Novel Prolactin in Non-Mammalian Vertebrates: Evolutionary Perspectives and Its In...Microinjectionzebrafish
Yang CH, Cheng CH, Chen GD, Liao WH, Chen YC, Huang KY, Hwang PP, Hwang SPL, Huang CJPLoS ONE. 2011;6(8):e23078. doi:10.1371/journal.pone.0023078Background The zona pellucida (ZP) domain is part of many extracellular proteins with diverse fu...Zona Pellucida Domain-Containing Protein β-Tectorin is Crucial for Zebrafish Proper Inner Ear Dev...Microinjectionzebrafish
Liu D-W, Tsai S-M, Lin B-F, Jiang Y-J, Wang W-PPLoS ONE. 2013;8(3):e58310. doi:10.1371/journal.pone.0058310Background There are four cell lineages derived from intestinal stem cells that are located at t...Fibroblast Growth Factor Receptor 2c Signaling Is Required for Intestinal Cell Differentiation in...Microinjectionzebrafish
Lemjabbar-Alaoui H, Sidhu SS, Mengistab A, Gallup M, Basbaum CPLoS ONE. 2011;6(3):e17489. doi:10.1371/journal.pone.0017489Background Tobacco smoke predisposes humans and animals to develop lung tumors, but the molecula...TACE/ADAM-17 Phosphorylation by PKC-Epsilon Mediates Premalignant Changes in Tobacco Smoke-Expose...cell culture: NCIH292
Yang DC, Tsai CC, Liao YF, Fu HC, Tsay HJ, Huang TF, Chen YH, Hung SCPLoS ONE. 2011;6(11):e27324. doi:10.1371/journal.pone.0027324Background Twist1a and twist1b are the principal components of twists that negatively regulate a...Twist Controls Skeletal Development and Dorsoventral Patterning by Regulating Runx2 in ZebrafishMicroinjectionzebrafish
Villegas R, Martin SM, O'Donnell K, Carrillo S, Sagasti A, Allende MLNeural Dev. 2012;7:19 doi:10.1186/1749-8104-7-19 [provisional pdf]Background Understanding the cellular mechanisms regulating axon degeneration and regeneration i...Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requ...Microinjectionzebrafish
Kizil C, Dudczig S, Kyritsis N, Machate A, Blaesche J, Kroehne V, Brand MNeural Dev. 2012;7:27 doi:10.1186/1749-8104-7-27Background Unlike mammals, zebrafish exhibits extensive neural regeneration after injury in adul...The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebraf...injection, intracerebroventricularzebrafish
Camarata T, Snyder D, Schwend T, Klosowiak J, Holtrup B, Simon H-GBMC Developmental Biology 2010, 10:104doi:10.1186/1471-213X-10-104Background Vertebrate limb development involves a reciprocal feedback loop between limb mesenchy...Pdlim7 is required for maintenance of the mesenchymal/epidermal Fgf signaling feedback loop durin...Microinjectionzebrafish
Hale LA, Fowler DK, Eisen JSPLoS ONE. 2011;6(10):e25841. doi:10.1371/journal.pone.0025841Background We previously showed that equivalence between two identified zebrafish motoneurons is...Netrin Signaling Breaks the Equivalence between Two Identified Zebrafish Motoneurons Revealing a ...Microinjectionzebrafish
Maragh S, Miller RA, Bessling SL, McGaughey DM, Wessels MW, de Graaf B, Stone EA, Bertoli-Avella ...BMC Dev Biol. 2011;11:62 doi:10.1186/1471-213X-11-62Background We recently identified Rbm24 as a novel gene expressed during mouse cardiac developme...Identification of RNA binding motif proteins essential for cardiovascular development Microinjectionzebrafish
Strasser MJ, Mackenzie NC, Dumstrei K, Nakkrasae LI, Stebler J, Raz EBMC Dev Biol. 2008 May 28;8:58Background Zebrafish germ cells contain granular-like structures, organized around the cell nucl...Control over the morphology and segregation of Zebrafish germ cell granules during embryonic deve...zebrafish
Chen CF, Chu CY, Chen TH, Lee SJ, Shen CN, Hsiao CDPLoS ONE. 2011;6(5):e20654. doi:10.1371/journal.pone.0020654Background Zebrafish skin is composed of enveloping and basal layers which form a first-line def...Establishment of a Transgenic Zebrafish Line for Superficial Skin Ablation and Functional Validat...Microinjectionzebrafish
Halbig KM, Lekven AC, Kunkel GRBMC Mol Biol. 2012;13:3 doi:10.1186/1471-2199-13-3Background ZNF143 is a sequence-specific DNA-binding protein that stimulates transcription of bo...The transcriptional activator ZNF143 is essential for normal development in zebrafishMicroinjectionzebrafish
Chassaing N, Sorrentino S, Davis EE, Martin-Coignard D, Iacovelli A, Paznekas W, Webb BD, Faye-P...J Med Genet. 2012;[Epub ahead of print] doi:10.1136/jmedgenet-2012-100892 Background Otocephaly or dysgnathia complex is characterised by mandibular hypoplasia/agenesis,...OTX2 mutations contribute to the otocephaly-dysgnathia complexzebrafish
Wang W, Zhang L-F , Gui Y-H, Song H-YChinese Med J. 2013;126(4):722-728Background Retinoic acid (RA) is a potent signaling molecule that plays pleiotropic roles in p...Retinol dehydrogenase, RDH1l, is essential for the heart development and cardiac performance in z...Microinjectionzebrafish
Zhang LF, Gui YH, Wang YX, Jiang Q, Song HYChinese Medical Journal. 2010;123(9):1182-9Background Tbx1 is the major candidate gene for DiGeorge syndrome (DGS). Similar to defects obse...Effect of Tbx1 knock-down on cardiac performance in zebrafishzebrafish
Cui S, Leyva-Vega M, Tsai EA, EauClaire SF, Glessner JT, Hakonarson H, Devoto M, Haber BA, Spinne...Gastroenterology. 2013;[Epub ahead of print] http://dx.doi.org/10.1053/j.gastro.2013.01.022Background & Aims Biliary atresia (BA) is a progressive fibro-inflammatory disorder of infants i...Evidence from Human and Zebrafish that GPC1 is a Biliary Atresia Susceptibility GeneMicroinjectionzebrafish
van der Werf CS, Wabbersen TD, Hsiao NH, Paredes J, Etchevers HC, Kroisel PM, Tibboel D, Babarit ...Gastroenterology. 2011 Dec 6. [Epub ahead of print]BACKGROUND & AIMS: Short-bowel syndrome usually results from surgical resection of the small int...CLMP is Required for Intestinal Development, and Loss-of-Function Mutations Cause Congenital Shor...Microinjectionzebrafish
Kanther M, Sun X, Mühlbauer M, Mackey LC, Flynn EJ 3rd, Bagnat M, Jobin C, Rawls JFGastroenterology. 2011 Jul;141(1):197-207. Epub 2011 Mar 24BACKGROUND & AIMS: The nuclear factor κ-light-chain enhancer of activated B cells (NF-κB) transc...Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the z...Microinjectionzebrafish
Renzi A, Demorrow S, Onori P, Carpino G, Mancinelli R, Meng F, Venter J, White M, Franchitto A, F...Hepatology. 2012 Oct 18. doi: 10.1002/hep.26105. [Epub ahead of print]Background & Aims: Secretin stimulates ductal secretion by interacting with secretin receptor (SR...Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine p...Vivo-MorpholinoRat
Kobayashi H, Spilde TL, Bhatia AM, Buckingham RB, Hembree MJ, Prasadan K, Preuett BL, Imamura M, ...Gastroenterology. 2002 Oct;123(4):1331-40BACKGROUND & AIMS: The early embryonic pancreas gives rise to exocrine (ducts and acini) and endo...Retinoid signaling controls mouse pancreatic exocrine lineage selection through epithelial-mesenc...oligo bathingMouse pancreas explants or epithelia
Flores MV, Hall CJ, Davidson AJ, Singh PP, Zon LI, Crosier KE, Crosier PSGastroenterology. 2008 Jul 31. [Epub ahead of print]BACKGROUND & AIMS: The ParaHox transcription factor Cdx2 is an essential determinant of intestina...Intestinal Differentiation in Zebrafish Requires Cdx1b, a Functional Equivalent of Mammalian Cdx2zebrafish
Monga SP, Monga HK, Tan X, Mule K, Pediaditakis P, Michalopoulos GKGastroenterology. 2003 Jan;124(1):202-216BACKGROUND & AIMS: Wnt/beta-catenin pathway activation occurs during liver growth in hepatoblasto...beta-catenin antisense studies in embryonic liver cultures: Role in proliferation, apoptosis, and...oligo bathingorgan culture: mouse liver explants
Weiss FU, Marques IJ, Woltering JM, Vlecken DH, Aghdassi A, Partecke LI, Heidecke CD, Lerch MM, B...Gastroenterology. 2009 Sep 9. [Epub ahead of print]BACKGROUND & AIMS:: The infiltrating ductal adenocarcinoma of the pancreas is among the most leth...Retinoic acid receptor (RAR) antagonists inhibit miR-10a expression and block metastatic behaviou...cell culture: pancreatic carcinoma; zebrafish
Zhang C, Song Y, Thompson DA, Madonna MA, Millhauser GL, Toro S, Varga Z, Westerfield M, Gamse J,...Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20164-71. Epub 2010 Oct 27Background adaptation is used by teleosts as one of a variety of camouflage mechanisms for avoida...Inaugural Article: Pineal-specific agouti protein regulates teleost background adaptationMicroinjectionzebrafish
Yin KJ, Chen SD, Lee JM, Xu J, Hsu CYStroke. 2002 Oct;33(10):2471-7BACKGROUND AND PURPOSE: Cells lacking the ATM (ataxia telangectasia mutated) gene are hypersensit...ATM gene regulates oxygen-glucose deprivation-induced nuclear factor-kappaB DNA-binding activity ...Special Deliverycell culture: mouse cerebral endothelial cells
Niwano T, Takatori N, Kumano G, Nishida HBiol Cell. 2009 Jun 8. [Epub ahead of print]Background information. In the embryos of various animals, the body elongates after gastrulation ...Wnt5 is required for notochord cell intercalation in the ascidian Halocynthia roretziMicroinjectionHalocynthia roretzi (ascidian)
Tecza A, Bugner V, Kühl M, Kühl SJBiol Cell. 2011 Jul 19. [Epub ahead of print]Background information. Pescadillo (pes1) and Peter Pan (ppan) are multifunctional proteins invol...Pes1 and ppan function during Xenopus laevis pronephros developmentXenopus laevis
Isaacs HV, Deconinck AE, Pownall MEBiol Cell. 2007 Mar;99(3):165-73Background information: FGF signaling is known to be required for many aspects of mesoderm format...FGF4 regulates blood and muscle specification in Xenopus laevisXenopus laevis
Gessert S, Maurus D, Kühl MBiol Cell. 2008 Nov;100(11):659-73BACKGROUND INFORMATION: RGM A (repulsive guidance molecule A) is a GPI (glycosylphosphatidylinosi...Repulsive guidance molecule A (RGM A) and its receptor neogenin during neural and neural crest ce...Xenopus laevis
Anantpadma M, Stein DA, Vrati SJ Antimicrob Chemother. 2010 Mar 18. [Epub ahead of print]Background Japanese encephalitis virus (JEV) has a significant impact on public health throughout...Inhibition of Japanese encephalitis virus replication in cultured cells and mice by a peptide-con...peptide-coupledmice and cell culture: Vero, Neuro2A and J774E cells
Coffman JA, Dickey-Sims C, Haug JS, McCarthy JJ, Robertson AJBMC Biol. 2004 May 7 [Epub ahead of print]Background Runx transcription factors are important regulators of metazoan development. The sea u...Evaluation of developmental phenotypes produced by morpholino antisense targeting of a sea urchin...MicroinjectionSea urchin, Strongylocentrotus purpuratus

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