Publications - Page 1
| Authors | Citation | Abstract | Title | Delivery Method | Organism |
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Cui WW, Low SE, Hirata H, Saint-Amant L, Geisler R, Hume RI, Kuwada JY. | J Neurosci. 2005 Jul 13;25(28):6610-20. | shocked (sho) is a zebrafish mutation that causes motor deficits attributable to CNS defects duri... | The zebrafish shocked gene encodes a glycine transporter and is essential for the function of ear... | Microinjection | zebrafish |
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Nakamura H, Katahira T, Sato T, Watanabe Y, Funahashi J. | Mech Dev. 2004 Sep;121(9):1137-43. | It remained very difficult to manipulate gene expression in chick embryos until the advent of in ... | Gain- and loss-of-function in chick embryos by electroporation. | Electroporation | chick embryo |
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Wada H, Iwasaki M, Sato T, Masai I, Nishiwaki Y, Tanaka H, Sato A, Nojima Y, Okamoto H. | Development. 2005 May;132(10):2273-85. Epub 2005 Apr 13. | In the developing vertebrate hindbrain, the characteristic trajectory of the facial (nVII) motor ... | Dual roles of zygotic and maternal Scribble1 in neural migration and convergent extension movemen... | Microinjection | zebrafish |
| Challa AK, McWhorter ML, Wang C, Seeger MA, Beattie CE. | Mech Dev. 2005 Oct;122(10):1073-86. | Roundabout (Robo) receptors and their secreted ligand Slits have been shown to function in a numb... | Robo3 isoforms have distinct roles during zebrafish development. | Microinjection | zebrafish |
| Ochi H, Pearson BJ, Chuang PT, Hammerschmidt M, Westerfield M. | Dev Biol. 2006 Sep 1;297(1):127-40. Epub 2006 May 6. | Sharp borders between cells with different developmental fates are important for patterning of in... | Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localiza... | Microinjection | zebrafish |
| Hinits Y, Osborn DP, Hughes SM | Development. 2009 Feb;136(3):403-14 | Myogenic regulatory factors of the Myod family (MRFs) are transcription factors essential for mam... | Differential requirements for myogenic regulatory factors distinguish medial and lateral somitic,... | | zebrafish |
| Khanna H, Davis EE, Murga-Zamalloa CA, Estrada-Cuzcano A, Lopez I, den Hollander AI, Zonneveld M... | Nat Genet. 2009 Jun;41(6):739-45. Epub 2009 May 10 | Despite rapid advances in the identification of genes involved in disease, the predictive power o... | A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies | Microinjection | zebrafish |
| Zhong H, Xin S, Zhao Y, Lu J, Li S, Gong J, Yang Z, Lin S | Mol Biosyst. 2010 Aug;6(8):1463-8. Epub 2010 May 19 | During the preclinical drug discovery process it remains a challenge to enable early elimination ... | Genetic approach to evaluate specificity of small molecule drug candidates inhibiting PLK1 using ... | | zebrafish |
| 秦艳芳, 向军俭, 刘东瀛. | Guangdong Medical Journal. 2002;6: (Chinese) | 目的用新的修饰型吗啉代反义寡核苷酸(M-ODN)抑制肿瘤细胞bcl-2的表达,探讨发展新的抗肿瘤药物的可能性.方法用吗啉代bcl-2反义寡核苷酸作用于K-562细胞,并与全硫代修饰的bcl-2反... | Inhabition of bcl-2 expression by antisense morpholino olgodexynucleotide | | |
| Aamar E, Dawid IB | Dev Biol. 2008 Jun 15;318(2):335-46. Epub 2008 Apr 9. | Protocadherin-18a (Pcdh18a) belongs to the delta2-protocadherins, which constitute the largest su... | Protocadherin-18a has a role in cell adhesion, behavior and migration in zebrafish development | | zebrafish |
| Aartsma-Rus A, Kaman WE, Bremmer-Bout M, Janson AA, Den Dunnen JT, Van Ommen GJ, Van Deutekom JC | Gene Ther. 2004 Sep;11(18):1391-8. | As small molecule drugs for Duchenne muscular dystrophy (DMD), antisense oligonucleotides (AONs) ... | Comparative analysis of antisense oligonucleotide analogs for targeted DMD exon 46 skipping in mu... | Special Delivery | Cell culture: primary human myoblast |
| Aartsma-Rus A, van Ommen GJ | RNA. 2007 Oct;13(10):1609-24. Epub 2007 Aug 7 | Antisense-mediated modulation of splicing is one of the few fields where antisense oligonucleotid... | Antisense-mediated exon skipping: A versatile tool with therapeutic and research applications | | |
| Aase K, Ernkvist M, Ebarasi L, Jakobsson L, Majumdar A, Yi C, Birot O, Ming Y, Kvanta A, Edholm D... | Genes Dev. 2007 Aug 15;21(16):2055-68 | The development of the embryonic vascular system into a highly ordered network requires precise c... | Angiomotin regulates endothelial cell migration during embryonic angiogenesis | | zebrafish |
| Abbas L, Whitfield TT | Development. 2009 Aug;136(16):2837-48 | Endolymph is the specialised extracellular fluid present inside the inner ear. In mammals, disrup... | Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim b... | | zebrafish |
| Abe H, Matsubara T, Iehara N, Nagai K, Takahashi T, Arai H, Kita T, Doi T | J Biol Chem. 2004 Apr 2;279(14):14201-6. Epub 2004 Jan 19. | Prolonged exposure to hyperglycemia is now recognized as the significantly causal factor of diabe... | Type IV collagen is transcriptionally regulated by Smad1 under advanced glycation end-products (A... | not published | cell culture: mouse glomerular mesangial cells |
| Abes R, Arzumanov A, Moulton H, Abes S, Ivanova G, Gait MJ, Iversen P, Lebleu B | J Pept Sci. 2008 Jan 30; [Epub ahead of print] | Rerouting the splicing machinery with steric-block oligonucleotides (ON) might lead to new therap... | Arginine-rich cell penetrating peptides: Design, structure-activity, and applications to alter pr... | peptide-coupled | |
| Abes R, Arzumanov AA, Moulton HM, Abes S, Ivanova GD, Iversen PL, Gait MJ, Lebleu B | Biochem Soc Trans. 2007 Aug;35(Pt 4):775-9 | Cationic CPPs (cell-penetrating peptides) have been used largely for intracellular delivery of lo... | Cell-penetrating-peptide-based delivery of oligonucleotides: an overview | peptide-coupled | |
| Abes R, Moulton HM, Clair P, Yang ST, Abes S, Melikov K, Prevot P, Youngblood DS, Iversen PL, Che... | Nucleic Acids Res. 2008 Nov;36(20):6343-54. Epub 2008 Sep 16.Click here to read | Redirecting the splicing machinery through the hybridization of high affinity, RNase H- incompete... | Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure-activity studies | peptide-coupled | cell culture: HeLa AntisenseTest System |
| Abes S, Moulton H, Turner J, Clair P, Richard JP, Iversen P, Gait MJ, Lebleu B | Biochem Soc Trans. 2007 Feb;35(Pt 1):53-5 | CPPs (cell-penetrating peptides) have given rise to much interest for the delivery of biomolecule... | Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-c... | peptide-coupled | cell culture: HeLa AntisenseTest System |
| Abes S, Moulton HM, Clair P, Prevot P, Youngblood DS, Wu RP, Iversen PL, Lebleu B | J Control Release. 2006 Dec 1;116(3):304-13. Epub 2006 Sep 30. | The efficient and non-toxic nuclear delivery of steric-block oligonucleotides (ON) is a prerequis... | Vectorization of morpholino oligomers by the (R-Ahx-R)(4) peptide allows efficient splicing corre... | peptide-coupled | cell culture: HeLa AntisenseTest System |
| Abraham E, Palevitch O, Ijiri S, Du SJ, Gothilf Y, Zohar Y | J Neuroendocrinol. 2008 Jan 17; [Epub ahead of print] | Normal migration of the GnRH-I neurones during early development, from the olfactory region to th... | Early Development of Gonadotrophin-Releasing Hormone-I Neurones and the Role of GnRH-I as an Auto... | | zebrafish |
| Abraham S, Yeo M, Montero-Balaguer M, Paterson H, Dejana E, Marshall CJ, Mavria G | Curr Biol. 2009 Apr 28;19(8):668-74. Epub 2009 Apr 2 | During new blood vessel formation, the cessation of angiogenic sprouting is necessary for the gen... | VE-Cadherin-mediated cell-cell interaction suppresses sprouting via signaling to MLC2 phosphoryla... | Microinjection | zebrafish |
| Abu-Daya A, Steer WM, Trollope AF, Friedeberg CE, Patient RK, Thorne AW, Guille MJ | Blood. 2005 Jul 15;106(2):514-20. Epub 2005 Apr 5 | Nucleosome assembly proteins (NAPs) bind core histones, facilitate chromatin remodeling, and can ... | Zygotic nucleosome assembly protein-like 1 has a specific, non-cell autonomous role in hematopoie... | Microinjection | Xenopus laevis |
| Abu-Elmagd M, Garcia-Morales C, Wheeler GN | Dev Biol. 2006 Oct 1;298(1):285-98. Epub 2006 Jun 27. | The neural crest is a multipotent cell population that migrates from the dorsal edge of the neura... | Frizzled7 mediates canonical Wnt signaling in neural crest induction | Microinjection | Xenopus |
| Acosta-Rodriguez EV, Montes CL, Motran CC, Zuniga EI, Liu FT, Rabinovich GA, Gruppi A | J Immunol. 2004 Jan 1;172(1):493-502 | The role of transcription factors in B cell survival and differentiation has been delineated duri... | Galectin-3 mediates IL-4-induced survival and differentiation of B cells: functional cross-talk a... | Special Delivery | cell culture: primary B cells, murine |
| Adams AM, Harding PL, Iversen PL, Coleman C, Fletcher S, Wilton SD | BMC Mol Biol. 2007 Jul 2;8(1):57 [Epub ahead of print] | ABSTRACT: BACKGROUND: Antisense oligonucleotides (AOs) can interfere with exon recognition and in... | Antisense oligonucleotide induced exon skipping and the dystrophin gene transcript: cocktails and... | | |
| Adini I, Rabinovitz I, Sun JF, Prendergast GC, Benjamin LE | Genes Dev. 2003 Nov 1;17(21):2721-32 | Blood vessel formation is a complex morphological process that is only beginning to be understood... | RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular de... | Special Delivery | cell culture: human endothelial cells (ECs) |
| Aerne B, Ish-Horowicz D | Development. 2004 Jul;131(14):3391-3399 | Segmentation in vertebrate embryos is controlled by a biochemical oscillator ('segmentation clock... | receptor tyrosine phosphatase psi is required for Delta/Notch signalling and cyclic gene expressi... | Microinjection | zebrafish |
| Afouda BA, Ciau-Uitz A, Patient R | Development. 2005 Feb;132(4):763-74. Epub 2005 Jan 19. | The individual contributions of the three vertebrate GATA factors to endoderm formation have been... | GATA4, 5 and 6 mediate TGFbeta maintenance of endodermal gene expression in Xenopus embryos | Microinjection | Xenopus |
| Afouda BA, Martin J, Liu F, Ciau-Uitz A, Patient R, Hoppler S | Development. 2008 Oct;135(19):3185-90. Epub 2008 Aug 20 | Cardiogenesis is inhibited by canonical Wnt/beta-catenin signalling and stimulated by non-canonic... | GATA transcription factors integrate Wnt signalling during heart development | Injection | Xenopus |
| Agathon A, Thisse B, Thisse C | Genesis. 2001 Jul;30(3):178-82 | No abstract available | Morpholino knock-down of antivin1 and antivin2 upregulates nodal signaling | Microinjection | zebrafish |
| Agathon A, Thisse C, Thisse B | Nature. 2003 Jul 24;424(6947):448-52. | Based on grafting experiments, Mangold and Spemann showed the dorsal blastopore lip of an amphibi... | The molecular nature of the zebrafish tail organizer | Microinjection | zebrafish |
| Agee SJ, Lyons DC, Weisblat DA | Dev Biol. 2006 Oct 1;298(1):1-11. Epub 2006 May 19. | The gene nanos (nos) is a maternal posterior group gene required for normal development of abdomi... | Maternal expression of a NANOS homolog is required for early development of the leech Helobdella ... | Microinjection | Helobdella (leech) |
| Aggad D, Mazel M, Boudinot P, Mogensen KE, Hamming OJ, Hartmann R, Kotenko S, Herbomel P, Lutfall... | J Immunol. 2009 Sep 15;183(6):3924-31. Epub 2009 Aug 28 | Because the availability of fish genomic data, the number of reported sequences for fish type II ... | The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific... | | zebrafish |
| Agrawal R, Tran U, Wessely O | Development. 2009 Dec;136(23):3927-36 | MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression at the post-t... | The miR-30 miRNA family regulates Xenopus pronephros development and targets the transcription fa... | Microinjection | Xenopus laevis |
| Ahmed H, Du SJ, Vasta GR | Glycoconj J. 2008 Sep 2. [Epub ahead of print] | We previously identified and characterized four galectin-1-like proteins in zebrafish, Drgal1-L1,... | Knockdown of a galectin-1-like protein in zebrafish (Danio rerio) causes defects in skeletal musc... | Microinjection | zebrafish |
| Ahn DG, Kourakis MJ, Rohde LA, Silver LM, Ho RK | Nature 2002 Jun 13;417(6890):754-8 | The T-box genes Tbx4 and Tbx5 have been shown to have key functions in the specification of the i... | T-box gene tbx5 is essential for formation of the pectoral limb bud. | Microinjection | zebrafish |
| Ahrens K, Schlosser G. | Dev Biol. 2005 Dec 1;288(1):40-59. Epub 2005 Nov 4. | Ectodermal placodes, from which many cranial sense organs and ganglia develop, arise from a commo... | Tissues and signals involved in the induction of placodal Six1 expression in Xenopus laevis. | Microinjection | Xenopus laevis |
| Aizawa H, Bianco IH, Hamaoka T, Miyashita T, Uemura O, Concha ML, Russell C, Wilson SW, Okamoto H | Curr Biol. 2005 Feb 8;15(3):238-43 | The habenulae are part of an evolutionarily highly conserved limbic-system conduction pathway tha... | Laterotopic representation of left-right information onto the dorso-ventral axis of a zebrafish m... | Microinjection | zebrafish |
| Akagi K, Kyun Park E, Mood K, Daar IO | Dev Dyn. 2002 Mar;223(2):216-28. | The docking protein SNT1/FRS2 (fibroblast growth factor receptor substrate 2) is implicated in th... | Docking protein SNT1 is a critical mediator of fibroblast growth factor signaling during Xenopus ... | Microinjection | Xenopus |
| Akanuma T, Nishida H | Dev Genes Evol. 2004 Jan;214(1):1-9. Epub 2003 Nov 15. | The larval ascidian brain (sensory vesicle) is located on the dorsal side of the trunk region and... | Ets-mediated brain induction in embryos of the ascidian Halocynthia roretzi | Microinjection | Halocynthia roretzi (ascidian) |
| Alarcón P, Rodríguez-Seguel E, Fernández-González A, Rubio R, Gómez-Skarmeta JL | Development. 2008 Aug 20. [Epub ahead of print] | The Iroquois (Irx) genes encode evolutionary conserved homeoproteins. We report that Xenopus gene... | A dual requirement for Iroquois genes during Xenopus kidney development | | Xenopus |
| Alberti P, Mergny JL. | Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1569-73. Epub 2003 Feb 06 | There is currently great interest in the design of nanodevices that are capable of performing lin... | DNA duplex-quadruplex exchange as the basis for a nanomolecular machine | not applicable | not applicable |
| Albertson RC, Payne-Ferreira TL, Postlethwait J, Yelick PC | Dev Dyn. 2005 Aug;233(4):1405-18. | To examine the roles of activin type II receptor signaling in craniofacial development, full-leng... | Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development | Microinjection | zebrafish |
| Alcaraz-Perez F, Mulero V, Cayuela ML | BMC Biotechnol. 2008 Oct 27;8(1):81. [Epub ahead of print] | ABSTRACT: BACKGROUND: The dual-luciferase assay has been widely used in cell lines to determine r... | Application of the dual-luciferase reporter assay to the analysis of promoter activity in zebrafi... | | zebrafish |
| Alders M, Hogan BM, Gjini E, Salehi F, Al-Gazali L, Hennekam EA, Holmberg EE, Mannens MM, Mulder ... | Nat Genet. 2009 Nov 22. [Epub ahead of print] | Lymphedema, lymphangiectasias, mental retardation and unusual facial characteristics define the a... | Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans | | zebrafish |
| Alexa K, Choe SK, Hirsch N, Etheridge L, Laver E, Sagerström CG | PLoS One. 2009;4(12):e8261 | We have isolated and characterized a novel zebrafish pancreas mutant. Mutant embryos lack express... | Maternal and Zygotic aldh1a2 Activity Is Required for Pancreas Development in Zebrafish | | zebrafish |
| Alexandre P, Reugels AM, Barker D, Blanc E, Clarke JD | Nat Neurosci. 2010 May 9. [Epub ahead of print] | In the developing CNS, asymmetric cell division is critical for maintaining the balanced producti... | Neurons derive from the more apical daughter in asymmetric divisions in the zebrafish neural tube | | zebrafish |
| Alexandrova EM, Thomsen GH | Dev Biol. 2006 Nov 15;299(2):398-410. Epub 2006 Aug 10. | The ubiquitin ligase Smurf1 can target a handful of signaling proteins for ubiquitin-mediated pro... | Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 p... | Microinjection | Xenopus laevis |
| Allen BG, Allen-Brady K, Weeks DL | Mech Dev. 2006 Oct;123(10):719-29. Epub 2006 Jul 26 | Normal vertebrate heart development depends upon the expression of homeodomain containing protein... | Reduction of XNkx2-10 expression leads to anterior defects and malformation of the embryonic hear... | Microinjection | Xenopus laevis |
