Publications - Page 1
| Authors | Citation | Abstract | Title | Delivery Method | Organism |
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| Chakhmakhcheva, O., Andrianov, M., Buryakova, A., Choob, M., & Efimov, V | Nucleosides Nucleotides 1999 18:1427-1428 | The solid phase synthesis of the three types of morpholino analogues of nucleic acids has been ac... | Synthesis and properties of some morpholino oligonucleotide analogues | | |
| Devi GR | Curr Opin Mol Ther. 2002 Apr;4(2):138-48. Review. | Prostate cancer, like most other solid tumors, represents a heterogeneous entity consisting of a ... | Prostate cancer: status of current treatments and emerging antisense-based therapies | | |
| Ghosh, C., Stein, D., Weller, D and Iversen, P | In Antisense Technology Part A, General Methods, Methods of Delivery, and RNA Studies. Methods in... | No abstract available. | Methods for Evaluation of Antisense Mechanisms of Action | | |
| Hudziak RM, Barofsky E, Barofsky DF, Weller DL, Huang SB, Weller DD | Antisense Nucleic Acid Drug Dev 1996 Winter;6(4):267-72 | Oligomers possessing the Morpholino phosphorodiamidate backbone were evaluated for resistance to ... | Resistance of morpholino phosphorodiamidate oligomers to enzymatic degradation | | not applicable |
| Iversen PL | Curr Opin Mol Ther 2001 Jun;3(3):235-8 | The phosphorodiamidate morpholino oligomers (PMOs) are a distinct class of oligonucleotide analog... | Phosphorodiamidate morpholino oligomers: favorable properties for sequence-specific gene inactiva... | | |
| Kang H, Chou PJ, Johnson WC Jr, Weller D, Huang SB, Summerton JE | Biopolymers 1992 Oct;32(10):1351-63 | CD spectra have been measured as a function of temperature for a number of ApA analogues with mod... | Stacking interactions of ApA analogues with modified backbones | | |
| Kipshidze N, Moses J, Shankar LR, Leon M | Curr Opin Mol Ther 2001 Jun;3(3):265-77 | One of the potential clinical applications of antisense therapy is the prevention or treatment of... | Perspectives on antisense therapy for the prevention of restenosis | | |
| Kipshidze, N., Keane, E., Stein, D., Chawla, P., Skrinska, V., Shandar, L.R., Komorowski, R., Hau... | XXIst Congress of the European Society of Cardiology, Ed. Francisco Navarro-Lopez, Monduzzi Edito... | | Local delivery of antisense phosphorodiamidate morpholino oligomer; Resten-NG inhibits myointimal... | | |
| Liu G, Zhang S, He J, Liu N, Gupta S, Rusckowski M, Hnatowich DJ. | Q J Nucl Med. 2002 Sep;46(3):233-43 | BACKGROUND: Despite in vivo use now over several years, in particular for nuclear medicine imagin... | The influence of chain length and base sequence on the pharmacokinetic behavior of 99mTc-morpholi... | | |
| Nasevicius A, Ekker SC | Curr Opin Mol Ther. 2001 Jun;3(3):224-8 | Unconventional antisense technology has entered the mainstream for both therapeutic and functiona... | The zebrafish as a novel system for functional genomics and therapeutic development applications | | zebrafish |
| Nielsen PE | Annu Rev Biophys Biomol Struct. 1995 24:167-83. Review | This review discusses the recent developments of DNA analogues with nonphosphodiester backbones i... | DNA analogues with nonphosphodiester backbones | | |
| Penberthy WT, Shafizadeh E, Lin S | Front Biosci. 2002 Jun 1;7:D1439-53 | Much of our current understanding of the function of genes modulating the normal process of embry... | The zebrafish as a model for human disease | | zebrafish |
| Smith AW, Matson DO, Stein DA, Skilling DE, Kroeker AD, Berke T, Iversen PL | Curr Opin Mol Ther. 2002 Apr;4(2):177-84 | The Earth's oceans are the primary reservoir for an emerging family of RNA viruses, the Calicivi... | Antisense treatment of caliciviridae: an emerging disease agent of animals and humans | | |
| Summerton J | Biochimica et Biophysica Acta 1999 1489: 141-158 | RNase H-competent phosphorothioates (S-DNAs) have dominated the antisense field in large part bec... | Morpholino Antisense Oligomers: The Case for an RNase-H Independent Structural Type | | |
| Summerton J and Dwight Weller | Antisense & Nucleic Acid Drug Development 1997 7:187-195 | Antisense promised major advances in treating a broad range of intractable diseases, but in recen... | Morpholino Antisense Oligomers: Design, Preparation and Properties. | | |
| Summerton J (submitted 1973, published 1979) | J Theor Biol 1979 May 7;78(1):61-75 | A general approach is proposed for development of anti-viral complexes capable of specific intrac... | Intracellular inactivation of specific nucleotide sequences: a general approach to the treatment ... | | |
| Tackett AJ, Wei L, Cameron CE, Raney KD | Nucleic Acids Res 2001 Jan 15;29(2):565-572 | Hepatitis C virus (HCV) helicase, non-structural protein 3 (NS3), is proposed to aid in HCV genom... | Unwinding of nucleic acids by HCV NS3 helicase is sensitive to the structure of the duplex | | |
| Wages JM Jr; Wages GM; Matthews P; Weller D; Summerton J | Biotechniques. 1997 Dec;23(6):1116-21 | Nucleic acid isolation for amplification-based diagnostics requires techniques that do not co-pur... | Affinity purification of RNA: sequence-specific capture by nonionic morpholino probes | | |
| Walsh EC, Stainier DY | Science. 2001 293: 1670-2 | Cardiac valve formation is a complex process that involves cell signaling events between the myoc... | UDP–Glucose Dehydrogenase Required for Cardiac Valve Formation in Zebrafish | | zebrafish |
| O'Hara MF, Nibbio BJ, Craig RC, Nemeth KR, Charlap JH, Knudsen TB | Reprod Toxicol. 2003 Jul-Aug;17(4):365-75 | The peripheral benzodiazepine receptor (Bzrp) has been implicated in the control of several proce... | Mitochondrial benzodiazepine receptors regulate oxygen homeostasis in the early mouse embryo | | Mouse embryo |
| Sazani P, Kole R | J Clin Invest. 2003 Aug;112(4):481-6 | An estimated 60% of all human genes undergo alternative splicing, a highly regulated process that... | Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing | | |
| Torigoe H, Kawahashi K, Tamura Y. | Nucleic Acids Res Suppl. 2003;(3):157-8. | We examined the effect of morpholino (MOR) backbone modification of triplex-forming oligonucleoti... | Promotion of triplex formation by morpholino modification: thermodynamic and kinetic studies. | | |
| Kipshidze NN, Porter TR, Dangas G, Yazdi H, Tio F, Xie F, Hellinga D, Fournadjiev J, Wolfram R, S... | Cardiovasc Radiat Med. 2003 Jul-Sep;4(3):152-9 | HYPOTHESIS: The antisense phosphorodiamidate morpholino oligomer (PMO), AVI-4126, has been effect... | Systemic targeted delivery of antisense with perflourobutane gas microbubble carrier reduced neoi... | | |
| Devi G | Cancer Gene Therapy, 2003, vol. 10, no. SUPP/1, pp. 9 | | In Vivo Efficacy of Phosphorodiamidate Morpholino-Based Antisense Oligomers in Tumor and Angiogen... | | |
| Hudziak RM, Weller DL, Weller DD, Barofsky E | Proceedings of the ASMS Conference on Mass Spectrometry and Allied Topics 1996 44:607 | | Mass Spectrometric Analysis of Morpholino Phosphorodiamidate Oligomers | | |
| Kirikoshi H, Katoh M | Int J Oncol. 2002 Mar;20(3):571-6 | PDZ-domain protein GIPC1/GIPC interacts with GTPase-activating protein RGS-GAIP, TGFbeta type III... | Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and... | | |
| Rubinstein AL | Current Opinion in Drug Discovery & Development 2003 6(2):218-223 | The study of zebrafish, a leading model organism for developmental biology, is rapidly expanding ... | Zebrafish: From disease modeling to drug discovery | | |
| Summerton J | In: Peptide Nucleic Acids, Morpholinos, and Related Antisense Biomolecules. Janson C. and During... | | Morpholinos and PNAs Compared | | |
| Tucker RP | Acta Histochemica et Cytochemica, 2002, vol. 35, no. 5, pp. 361-366 | | Using Antisense Morpholino Oligos to Knockdown Gene Expression in the Chicken Embryo | | chick embryo |
| Ohashi S, Abe H, Takahashi T, Yamamoto Y, Takeuchi M, Arai H, Nagata K, Kita T, Okamoto H, Yamamo... | J Biol Chem. 2004 May 7;279(19):19816-23. Epub 2004 Mar 05. | Advanced glycation end products (AGEs) appear to contribute to the diabetic complications. This s... | Advanced glycation end products increase collagen-specific chaperone protein in mouse diabetic ne... | | cell culture: mouse glomerular mesangial cells |
| Pannier AK, Arora V, Iversen PL, Brand RM | Int J Pharm. 2004 May 4;275(1-2):217-26. | The skin is the largest organ in the body and an obvious route for both local and systemic drug d... | Transdermal delivery of phosphorodiamidate Morpholino oligomers across hairless mouse skin. | | |
| Devi GR | Drug News Perspect. 2004 Mar;17(2):127-34 | Progression to androgen independence combined with chemotherapy resistance remains one of the pri... | XIAP as target for therapeutic apoptosis in prostate cancer | | |
| Okamoto H, Hirate Y, Ando H | Frontiers in Bioscience. 2004 Jan 1;9:93-9 | | Systematic Identification of Factors in Zebrafish Regulating the Early Midbrain and Cerebellar De... | | zebrafish |
| He J, Liu G, Gupta S, Zhang Y, Rusckowski M, Hnatowich DJ | J Nucl Med. 2004 Jun;45(6):1087-95 | Conventional nuclear medicine imaging with large radiolabeled molecules such as antitumor antibod... | Amplification targeting: a modified pretargeting approach with potential for signal amplification... | | mice, nude |
| Chen HH, Maeda T, Mullett SJ, Stewart AF | Genesis. 2004 Aug;39(4):273-9 | TEF-1 transcription factors regulate gene expression in skeletal muscle but are not muscle-specif... | Transcription cofactor Vgl-2 is required for skeletal muscle differentiation | | cell culture: myogenic C(2)C(12) cells and chick embryos |
| Iversen PL, Kipshidze N, Moses JW, Leon MB | Methods Mol Med. 2004;106:37-50 | In 1977, percutaneous transluminal coronary angioplasty (PTCA) was first introduced, and it has b... | Local application of antisense for prevention of restenosis | | |
| Arora V | Methods Mol Med. 2004;106:273-92 | The concept of metabolic redirection involves shifting the metabolism of a substrate away from on... | Antisense strategies for redirection of drug metabolism: using Paclitaxel as a model | | rats, Sprague Dawley |
| Jubin R | Methods Mol Med. 2004;106:309-22 | Hepatitis C virus (HCV) contains a positive-sense, single-stranded RNA viral genome that encodes ... | Optimizing electroporation conditions for intracellular delivery of morpholino antisense oligonuc... | | |
| Arora V, Devi G, Iversen PL | Current Pharmaceutical Biotechnology 2004, 5(5):431-439 | Antisense technology constitutes development of sequence-specific DNA or RNA analogs that can blo... | Neutrally Charged Phosphorodiamidate Morpholino Antisense Oligomers: Uptake, Efficacy and Pharmac... | | |
| Stephens AC | Curr Opin Mol Ther. 2004 Oct;6(5):551-8 | AVI BioPharma is developing AVI-4126, an antisense oligonucleotide targeted to c-myc mRNA for the... | Technology evaluation: AVI-4126, AVI BioPharma | | |
| Angerer LM, Angerer RC | Methods Cell Biol. 2004;74:699-711 | No abstract available. | Disruption of gene function using antisense morpholinos. | | |
| Manning AG, Crawford BD, Waskiewicz AJ, Pilgrim DB | Genesis. 2004 Dec;40(4):223-30. | The UNC-119 proteins, found in all metazoans examined, are highly conserved at both the sequence ... | UNC-119 homolog required for normal development of the zebrafish nervous system | | zebrafish |
| Stuermer CA, Plattner H, Gustafsson JA | Biochem Soc Symp. 2005;(72):109-18 | Reggie-1 and reggie-2 are two evolutionarily highly conserved proteins which are up-regulated in ... | Lipids, Rafts and Traffic: Chapter 11 - The 'lipid raft' microdomain proteins reggie-1 and reggie... | | zebrafish |
| Ge Q, Stein D, Kroeker A, Iversen P, Chen J | Program and abstracts of the 44th Interscience Conference of Antimicrobial Agents and Chemotherap... | | Inhibition of influenza A virus production in vero cells with morpholino oligomers | | |
| Kloosterman WP, Wienholds E, Ketting RF, Plasterk RH | Nucleic Acids Res. 2004 Dec 07;32(21):6284-91 | MicroRNAs (miRNAs) are involved in the regulation of gene expression at the post-transcriptional ... | Substrate requirements for let-7 function in the developing zebrafish embryo | | zebrafish |
| Kipshidze N, Tsapenko M, Iversen P, Burger D | Expert Opin Biol Ther. 2005 Jan;5(1):79-89 | Recent advances in vascular gene transfer have shown potential new treatment modalities for cardi... | Antisense therapy for restenosis following percutaneous coronary intervention | | human |
| Iversen PL, Newbry S | Curr Opin Mol Ther 2005 7(2):104-8 | No abstract available | Manipulation of zebrafish embryogenesis by phosphorodiamidate morpholino oligomers indicates mini... | | zebrafish |
| Peterson RT | Drug Discovery Today: Technologies. 2004 1(1):49-54 | The easy identification of phenotypes in the transparent zebrafish embryo has enabled numerous ge... | Discovery of therapeutic targets by phenotype-based zebrafish screens | | zebrafish |
| Magie CR, Daly M, Martindale MQ | Dev Biol. 2007 Mar 6; [Epub ahead of print] | Gastrulation is a central event in metazoan development, involving many cellular behaviors includ... | Gastrulation in the cnidarian Nematostella vectensis occurs via invagination not ingression | | Nematostella vectensis (cnidarian) |
| Mahadevan B, Arora V, Schild LJ, Keshava C, Cate ML, Iversen PL, Poirier MC, Weston A, Pereira C,... | Mol Carcinog. 2006 Feb;45(2):118-25. | Tamoxifen (TAM) is widely used in the treatment and prevention of breast cancer. There is clear e... | Reduction in tamoxifen-induced CYP3A2 expression and DNA adducts using antisense technology | | |
