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Morpholino Publications Database

Publications - Page 9
AuthorsCitationAbstractTitleDelivery MethodOrganism
Wang Y, Janicki P, Köster I, Berger CD, Wenzl C, Großhans J, Steinbeisser HGenes Dev. 2008 Apr 1;22(7):878-883Xenopus Paraxial Protocadherin (xPAPC) has signaling functions that are essential for convergent ...Xenopus Paraxial Protocadherin regulates morphogenesis by antagonizing SproutyXenopus
Thomas P, Pang Y, Zhu Y, Detweiler C, Doughty KSteroids. 2004 Aug;69(8-9):567-73Progestin hormones exert rapid, nongenomic actions on a variety of target tissues in fish. The in...Multiple rapid progestin actions and progestin membrane receptor subtypes in fishzebrafish
Bello V, Sirour C, Moreau N, Denker E, Darribère TDev Biol. 2008 May 1;317(1):106-20. Epub 2008 Mar 4.Dystroglycan (Dg) is a laminin receptor that is expressed at the interface between the basement m...A function for dystroglycan in pronephros development in Xenopus laevisXenopus laevis
Carney TJ, von der Hardt S, Sonntag C, Amsterdam A, Topczewski J, Hopkins N, Hammerschmidt MDevelopment. 2007 Oct;134(19):3461-71. Epub 2007 Aug 29Epithelial integrity requires the adhesion of cells to each other as well as to an underlying bas...Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial int...zebrafish
Nishio SI, Kakizawa T, Chatelain G, Triqueneaux G, Brunet F, Rambaud J, Lamonerie T, Laudet VMol Endocrinol. 2008 Jan;22(1):23-32. Epub 2007 Sep 13The pineal gland plays a central role in the photoneuroendocrine system and acts as a photosensor...Otx5 Regulates Pineal Expression Of The Zebrafish Rev-ErbAlpha Through A New Dna Binding Sitezebrafish
Wang HW, Muguira M, Liu WD, Zhang T, Chen C, Aucoin R, Breslin M, Lan MJ Endocrinol. 2008 Jul;198(1):29-39. Epub 2008 Apr 16.In this study, an INSM1-binding site in the proximal promoter sequence of the insulin gene was id...Identification of an INSM1 Binding Site in the Insulin Promoter: Negative Regulation of the Insul...Mouse embryonic pancreas
Yang J, Wu J, Tan C, Klein PSDevelopment. 2003 Dec;130(23):5569-78. Epub 2003 Oct 1.The Wnt/beta-catenin pathway plays important roles during embryonic development and growth contro...PP2A:B56epsilon is required for Wnt/beta-catenin signaling during embryonic developmentXenopus
Phillips BT, Storch EM, Lekven AC, Riley BBDevelopment. 2004 Feb;131(4):923-31Induction of the otic placode, which gives rise to all tissues comprising the inner ear, is a fun...A direct role for Fgf but not Wnt in otic placode inductionzebrafish
Hassler C, Cruciat CM, Huang YL, Kuriyama S, Mayor R, Niehrs CDevelopment. 2007 Dec;134(23):4255-63. Epub 2007 Oct 31Kremen 1 and 2 (Krm1/2) are transmembrane receptors for Wnt antagonists of the Dickkopf (Dkk) fam...Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signal...Xenopus
Yusuke T, Hidetaka TNippon Kagakkai Koen Yokoshu 2003; 83(2):1126 (Japanese)Triplex DNA is usually formed through the sequence-specific interaction of a single-stranded homo...Thermodynamic and Kinetic Effects of Morpholino Modification on Pyrimidine Motif Triplex Formatio...
Li C, Inglis PN, Leitch CC, Efimenko E, Zaghloul NA, Mok CA, Davis EE, Bialas NJ, Healey MP, Héon...PLoS Genet. 2008 Mar 28;4(3):e1000044MIP-T3 is a human protein found previously to associate with microtubules and the kinesin-interac...An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexeszebrafish
Liu Y, Zhao J, Liu J, Zhang H, Liu M, Xiao XCell Stress Chaperones. 2008 Autumn;13(3):337-45. Epub 2008 Apr 1.Krüppel-like factor 4 (KLF4) is a transcription factor that is abundantly expressed in various or...Upregulation of the constitutively expressed HSC70 by KLF4
Yamaguchi M, Fujimori-Tonou N, Yoshimura Y, Kishi T, Okamoto H, Masai IDevelopment. 2008 Feb 20; [Epub ahead of print]Apoptosis is often observed in developing tissues. However, it remains unclear how the apoptotic ...Mutation of DNA primase causes extensive apoptosis of retinal neurons through the activation of D...zebrafish
Sherwood V, Manbodh R, Sheppard C, Chalmers ADMol Biol Cell. 2008 Apr;19(4):1772-82. Epub 2008 Feb 13.Monitoring Editor: Marianne Bronner-Fraser Mitosis is a fundamental feature of all cellular organ...RASSF7 is a Member of a New Family of RAS Association Domain-Containing Proteins and is Required ...Xenopus
Monteiro R, van Dinther M, Bakkers J, Wilkinson R, Patient R, Ten Dijke P, Mummery CDev Biol. 2008 Mar 1;315(1):55-71. Epub 2007 Dec 15.Ligands of the transforming growth factor beta (TGFbeta) superfamily, like Nodal and bone morphog...Two novel type II receptors mediate BMP signalling and are required to establish left-right asymm...zebrafish
Chiou MJ, Wang YD, Kuo CM, Chen JC, Chen JYDNA Cell Biol. 2007 Nov;26(11):781-790Mitogen-activated protein kinase (MAPK) plays a pivotal role in intracellular actions in response...Functional Analysis of Mitogen-Activated Protein Kinase-3 (MAPK3) and Its Regulation of the Promo...zebrafish
Aquilina-Beck A, Ilagan K, Liu Q, Liang JOBMC Dev Biol. 2007 Nov 8;7(1):126 [Epub ahead of print] ABSTRACT: BACKGROUND: Nodals are secreted signaling proteins with many roles in vertebrate develo...Nodal signaling is required for closure of the anterior neural tube in zebrafishzebrafish
Ribeiro I, Kawakami Y, Büscher D, Raya A, Rodríguez-León J, Morita M, Rodríguez Esteban C, Izpisú...PLoS ONE. 2007 Apr 25;2(4):e398BACKGROUND: The heart forms from a linear tube that is subject to complex remodeling during embry...Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodelingzebrafish
Hu ZG, Chen Y, Zhou Q, Lv XY, Zhang Z, Wang YD, Xiao Y, Guo H, Liu YH, Tan RZ, Li QW, Bian GH, We...Biochem Biophys Res Commun. 2008 Jan 11;365(2):214-20. Epub 2007 Nov 5.SH3 domain binding protein 5 like (xSH3BP5L) gene encodes a protein that is a new found member of...Characterization of a novel Xenopus SH3 domain binding protein 5 like (xSH3BP5L) geneXenopus laevis
Postel R, Vakeel P, Topczewski J, Knöll R, Bakkers JDev Biol. 2008 Jun 1;318(1):92-101. Epub 2008 Mar 26.Mechanical instability of skeletal muscle cells is the major cause of congenital muscular dystrop...Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-E...zebrafish
Grzmil M, Whiting D, Maule J, Anastasaki C, Amatruda JF, Kelsh RN, Norbury CJ, Patton EEPLoS ONE. 2007 Sep 26;2(9):e959BACKGROUND: Int-6 (integration site 6) was identified as an oncogene in a screen of tumorigenic m...The INT6 Cancer Gene and MEK Signaling Pathways Converge during Zebrafish Developmentzebrafish
Stein DA, Shi PYFront Biosci. 2008 Jan 1;13:1385-95The genus Flavivirus in the family Flaviviridae consists of many arthropod-transmitted human path...Nucleic acid-based inhibition of flavivirus infections
Schorderet DF, Nichini O, Boisset G, Polok B, Tiab L, Mayeur H, Raji B, de la Houssaye G, Abitbol...Am J Hum Genet. 2008 May;82(5):1178-84.Several dysmorphic syndromes affect the development of both the eye and the ear, but only a few a...Mutation in the Human Homeobox Gene NKX5-3 Causes an Oculo-Auricular Syndromezebrafish
Gongal PA, Waskiewicz AJHum Mol Genet. 2008 Feb 15;17(4):525-38. Epub 2007 Nov 12.Holoprosencephaly (HPE) is the most common human congenital forebrain defect, affecting specifica...Zebrafish model of Holoprosencephaly demonstrates a key role for TGIF in regulating retinoic acid...zebrafish
McWhorter ML, Boon KL, Horan ES, Burghes AH, Beattie CEDev Neurobiol. 2008 Feb 1;68(2):182-94.A paramount question in spinal muscular atrophy (SMA) research is why reduced levels of SMN, a ub...The SMN binding protein gemin2 is not involved in motor axon outgrowthzebrafish
Berry FB, Skarie JM, Mirzayans F, Fortin Y, Hudson TJ, Raymond V, Link BA, Walter MAHum Mol Genet. 2008 Feb 15;17(4):490-505. Epub 2007 Nov 9.Mutations in the human FOXC1 transcription factor gene underlie Axenfeld-Rieger (AR) syndrome, a ...FOXC1 is required for cell viability and resistance to oxidative stress in the eye through the tr...zebrafish
Leung KM, van Horck FP, Lin AC, Allison R, Standart N, Holt CENat Neurosci. 2006 Oct;9(10):1247-56. Epub 2006 Sep 17Local protein synthesis regulates the turning of growth cones to guidance cues, yet little is kno...Asymmetrical beta-actin mRNA translation in growth cones mediates attractive turning to netrin-1Xenopus laevis
Li X, Wang S, Qi J, Echtenkamp SF, Chatterjee R, Wang M, Boons GJ, Dziarski R, Gupta DImmunity. 2007 Sep;27(3):518-29Peptidoglycan recognition proteins (PGRPs) are structurally conserved through evolution, but thei...Zebrafish peptidoglycan recognition proteins are bactericidal amidases essential for defense agai...zebrafish
Wingert RA, Selleck R, Yu J, Song HD, Chen Z, Song A, Zhou Y, Thisse B, Thisse C, McMahon AP, Dav...PLoS Genet. 2007 Oct 19;3(10):1922-38Kidney function depends on the nephron, which comprises a blood filter, a tubule that is subdivid...The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish proneph...zebrafish
Morris SA, Almeida AD, Tanaka H, Ohta K, Ohnuma SPLoS ONE. 2007 Oct 10;2(10):e1004BACKGROUND: Cell-cell communication is essential in tissue patterning. In early amphibian develop...Tsukushi Modulates Xnr2, FGF and BMP Signaling: Regulation of Xenopus Germ Layer FormationXenopus laevis
Silvestri LS, Ruthel G, Kallstrom G, Warfield KL, Swenson DL, Nelle T, Iversen PL, Bavari S, Aman...J Infect Dis. 2007 Nov 15;196 Suppl 2:S264-70Budding of Ebola virus (EBOV) particles from the plasma membrane of infected cells requires viral...Involvement of Vacuolar Protein Sorting Pathway in Ebola Virus Release Independent of TSG101 Inte...mice
Filippi A, Duerr K, Ryu S, Willaredt M, Holzschuh J, Driever WBMC Dev Biol. 2007 Dec 5;7(1):135 [Epub ahead of print]ABSTRACT: RESULTS: We use a combination of fluorescent in situ hybridization and immunohistochem...Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic ne...zebrafish
Kipshidze N, Iversen P, Overlie P, Dunlap T, Titus B, Lee D, Moses J, O'Hanley P, Lauer M, Leon M...Cardiovasc Revasc Med. 2007 Oct-Dec;8(4):230-5BACKGROUND: A novel antisense phosphorodiamidate morpholino oligomer, AVI-4126, was shown to be e...First human experience with local delivery of novel antisense AVI-4126 with Infiltrator catheter ...
Wheeler TM, Lueck JD, Swanson MS, Dirksen RT, Thornton CAJ Clin Invest. 2007 Nov 15; [Epub ahead of print]In myotonic dystrophy (dystrophia myotonica [DM]), an increase in the excitability of skeletal mu...Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of my...mice
Lee JA, Anholt RR, Cole GJMech Dev. 2007 Sep 29; [Epub ahead of print] Olfactomedins comprise a diverse family of secreted glycoproteins, which includes noelin, tiarin,...Olfactomedin-2 mediates development of the anterior central nervous system and head structures in...zebrafish
Ishibashi H, Matsumura N, Hanafusa H, Matsumoto K, Robertis EM, Kuroda HMech Dev. 2007 Oct 12; [Epub ahead of print]The blastula Chordin- and Noggin-expressing (BCNE) center located in the dorsal animal region of ...Expression of Siamois and Twin in the blastula Chordin/Noggin signaling center is required for br...Xenopus laevis
Tufro A, Teichman J, Woda C, Villegas GMech Dev. 2008 May-Jun;125(5-6):558-68. Epub 2007 Dec 28.Class 3 semaphorins are guidance proteins involved in axon pathfinding, vascular patterning and l...Semaphorin3a inhibits ureteric bud branching morphogenesis
Galloway JL, Wingert RA, Thisse C, Thisse B, Zon LIExp Hematol. 2008 Apr;36(4):424-32. Epub 2008 Feb 4.OBJECTIVE: The specification and differentiation of hematopoietic stem cells into red blood cells...Combinatorial regulation of novel erythroid gene expression in zebrafishzebrafish
Kurokawa H, Saito D, Nakamura S, Katoh-Fukui Y, Ohta K, Baba T, Morohashi KI, Tanaka MProc Natl Acad Sci U S A. 2007 Oct 23;104(43):16958-63. Epub 2007 Oct 16To further elucidate the roles of germ cells in the sex differentiation of gonads, we have used t...Germ cells are essential for sexual dimorphism in the medaka gonadmedaka
Matsson H, Eason J, Bookwalter CS, Klar J, Gustavsson P, Sunnegardh J, Enell H, Jonzon A, Vikkula...Hum Mol Genet. 2008 Jan 15;17(2):256-65. Epub 2007 Oct 18Atrial septal defect (ASD) is one of the most frequent congenital heart defects (CHD) with a vari...Alpha-cardiac actin mutations produce atrial septal defectschick embryo
Li Z, Korzh V, Gong ZBMC Dev Biol. 2007 Oct 19;7(1):117 [Epub ahead of print] ABSTRACT: BACKGROUND: The number of genes characterized in liver development is steadily increasi...Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and ear...zebrafish
Krock BL, Perkins BDJ Cell Sci. 2008 Jun 1;121(Pt 11):1907-15Defects in protein transport within vertebrate photoreceptors can result in photoreceptor degener...The intraflagellar transport protein IFT57 is required for cilia maintenance and regulates IFT-pa...zebrafish
Fu X, Wang Y, Schetle N, Gao H, Pütz M, von Gersdorff G, Walz G, Kramer-Zucker AGJ Am Soc Nephrol. 2008 Jul;19(7):1342-51. Epub 2008 Apr 16TRPP2, also known as polycystin-2, is a calcium permeable nonselective cation channel that is mut...The subcellular localization of TRPP2 modulates its functionzebrafish
Woolner S, O'Brien LL, Wiese C, Bement WMJ Cell Biol. 2008 Jul 14;182(1):77-88. Epub 2008 Jul 7.Mitotic spindles are microtubule-based structures responsible for chromosome partitioning during ...Myosin-10 and actin filaments are essential for mitotic spindle function
Zhang B, Dong H, Stein DA, Iversen PL, Shi PYVirology. 2008 Mar 30;373(1):1-13. Epub 2008 Feb 6.West Nile virus (WNV) genome cyclization and replication require two pairs of long-distance RNA i...West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA int...West Nile Virus
Nagel M, Tahinci E, Symes K, Winklbauer RDevelopment. 2004 Jun;131(11):2727-36. Epub 2004 May 5In vertebrates, PDGFA and its receptor, PDGFRalpha, are expressed in the early embryo. Impairing ...Guidance of mesoderm cell migration in the Xenopus gastrula requires PDGF signalingXenopus
Carradice D, Lieschke GJBlood. 2008 Apr 1;111(7):3331-42. Epub 2008 Jan 8.After a decade of the "modern era" of zebrafish in hematology research, what have been their majo...Zebrafish in hematology: sushi or science?Zebrafish (lit. review)
Ke Z, Kondrichin I, Gong Z, Korzh VMol Cell Neurosci. 2008 Feb;37(2):388-401. Epub 2007 Nov 1.It has been proposed that the downstream mediator of the evolutionarily conserved Hedgehog pathwa...Combined activity of the two Gli2 genes of zebrafish play a major role in Hedgehog signaling duri...zebrafish
Hendricks M, Mathuru AS, Wang H, Silander O, Kee MZ, Jesuthasan SMol Cell Neurosci. 2008 Feb;37(2):271-83. Epub 2007 Oct 16.Growth cones are guided to their final destination by intermediate targets. Here, we identify int...Disruption of Esrom and Ryk identifies the roof plate boundary as an intermediate target for comm...zebrafish
van den Akker WM, Brox A, Puelles L, Durston AJ, Medina LJ Comp Neurol. 2007 Nov 19;506(2):211-223 [Epub ahead of print]Knockout of the Nkx2.1 (Titf-1) homeobox gene in the mouse leads to severe malformation and size ...Comparative functional analysis provides evidence for a crucial role for the homeobox gene Nkx2.1...Xenopus laevis

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