Publications - Page 1
| Authors | Citation | Abstract | Title | Delivery Method | Organism |
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| Chakhmakhcheva, O., Andrianov, M., Buryakova, A., Choob, M., & Efimov, V | Nucleosides Nucleotides 1999 18:1427-1428 | The solid phase synthesis of the three types of morpholino analogues of nucleic acids has been ac... | Synthesis and properties of some morpholino oligonucleotide analogues | | |
| Devi GR | Curr Opin Mol Ther. 2002 Apr;4(2):138-48. Review. | Prostate cancer, like most other solid tumors, represents a heterogeneous entity consisting of a ... | Prostate cancer: status of current treatments and emerging antisense-based therapies | | |
| Ghosh, C., Stein, D., Weller, D and Iversen, P | In Antisense Technology Part A, General Methods, Methods of Delivery, and RNA Studies. Methods in... | No abstract available. | Methods for Evaluation of Antisense Mechanisms of Action | | |
| Iversen PL | Curr Opin Mol Ther 2001 Jun;3(3):235-8 | The phosphorodiamidate morpholino oligomers (PMOs) are a distinct class of oligonucleotide analog... | Phosphorodiamidate morpholino oligomers: favorable properties for sequence-specific gene inactiva... | | |
| Kang H, Chou PJ, Johnson WC Jr, Weller D, Huang SB, Summerton JE | Biopolymers 1992 Oct;32(10):1351-63 | CD spectra have been measured as a function of temperature for a number of ApA analogues with mod... | Stacking interactions of ApA analogues with modified backbones | | |
| Kipshidze N, Moses J, Shankar LR, Leon M | Curr Opin Mol Ther 2001 Jun;3(3):265-77 | One of the potential clinical applications of antisense therapy is the prevention or treatment of... | Perspectives on antisense therapy for the prevention of restenosis | | |
| Kipshidze, N., Keane, E., Stein, D., Chawla, P., Skrinska, V., Shandar, L.R., Komorowski, R., Hau... | XXIst Congress of the European Society of Cardiology, Ed. Francisco Navarro-Lopez, Monduzzi Edito... | | Local delivery of antisense phosphorodiamidate morpholino oligomer; Resten-NG inhibits myointimal... | | |
| Liu G, Zhang S, He J, Liu N, Gupta S, Rusckowski M, Hnatowich DJ. | Q J Nucl Med. 2002 Sep;46(3):233-43 | BACKGROUND: Despite in vivo use now over several years, in particular for nuclear medicine imagin... | The influence of chain length and base sequence on the pharmacokinetic behavior of 99mTc-morpholi... | | |
| Nielsen PE | Annu Rev Biophys Biomol Struct. 1995 24:167-83. Review | This review discusses the recent developments of DNA analogues with nonphosphodiester backbones i... | DNA analogues with nonphosphodiester backbones | | |
| Smith AW, Matson DO, Stein DA, Skilling DE, Kroeker AD, Berke T, Iversen PL | Curr Opin Mol Ther. 2002 Apr;4(2):177-84 | The Earth's oceans are the primary reservoir for an emerging family of RNA viruses, the Calicivi... | Antisense treatment of caliciviridae: an emerging disease agent of animals and humans | | |
| Stein D, Foster E, Huang SB, Weller D, Summerton J | Antisense Nucleic Acid Drug Dev. 1997 Jun;7(3):151-7 | Cell-free translation studies were carried out to compare the efficacy and specificity of four an... | A specificity comparison of four antisense types: morpholino, 2'-O-methyl RNA, DNA, and phosphoro... | in vitro: TNT | |
| Summerton J | Biochimica et Biophysica Acta 1999 1489: 141-158 | RNase H-competent phosphorothioates (S-DNAs) have dominated the antisense field in large part bec... | Morpholino Antisense Oligomers: The Case for an RNase-H Independent Structural Type | | |
| Summerton J and Dwight Weller | Antisense & Nucleic Acid Drug Development 1997 7:187-195 | Antisense promised major advances in treating a broad range of intractable diseases, but in recen... | Morpholino Antisense Oligomers: Design, Preparation and Properties. | | |
| Summerton J (submitted 1973, published 1979) | J Theor Biol 1979 May 7;78(1):61-75 | A general approach is proposed for development of anti-viral complexes capable of specific intrac... | Intracellular inactivation of specific nucleotide sequences: a general approach to the treatment ... | | |
| Tackett AJ, Wei L, Cameron CE, Raney KD | Nucleic Acids Res 2001 Jan 15;29(2):565-572 | Hepatitis C virus (HCV) helicase, non-structural protein 3 (NS3), is proposed to aid in HCV genom... | Unwinding of nucleic acids by HCV NS3 helicase is sensitive to the structure of the duplex | | |
| Wages JM Jr; Wages GM; Matthews P; Weller D; Summerton J | Biotechniques. 1997 Dec;23(6):1116-21 | Nucleic acid isolation for amplification-based diagnostics requires techniques that do not co-pur... | Affinity purification of RNA: sequence-specific capture by nonionic morpholino probes | | |
| Sazani P, Kole R | J Clin Invest. 2003 Aug;112(4):481-6 | An estimated 60% of all human genes undergo alternative splicing, a highly regulated process that... | Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing | | |
| Torigoe H, Kawahashi K, Tamura Y. | Nucleic Acids Res Suppl. 2003;(3):157-8. | We examined the effect of morpholino (MOR) backbone modification of triplex-forming oligonucleoti... | Promotion of triplex formation by morpholino modification: thermodynamic and kinetic studies. | | |
| Kipshidze NN, Porter TR, Dangas G, Yazdi H, Tio F, Xie F, Hellinga D, Fournadjiev J, Wolfram R, S... | Cardiovasc Radiat Med. 2003 Jul-Sep;4(3):152-9 | HYPOTHESIS: The antisense phosphorodiamidate morpholino oligomer (PMO), AVI-4126, has been effect... | Systemic targeted delivery of antisense with perflourobutane gas microbubble carrier reduced neoi... | | |
| Devi G | Cancer Gene Therapy, 2003, vol. 10, no. SUPP/1, pp. 9 | | In Vivo Efficacy of Phosphorodiamidate Morpholino-Based Antisense Oligomers in Tumor and Angiogen... | | |
| Hudziak RM, Weller DL, Weller DD, Barofsky E | Proceedings of the ASMS Conference on Mass Spectrometry and Allied Topics 1996 44:607 | | Mass Spectrometric Analysis of Morpholino Phosphorodiamidate Oligomers | | |
| Kirikoshi H, Katoh M | Int J Oncol. 2002 Mar;20(3):571-6 | PDZ-domain protein GIPC1/GIPC interacts with GTPase-activating protein RGS-GAIP, TGFbeta type III... | Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and... | | |
| Rubinstein AL | Current Opinion in Drug Discovery & Development 2003 6(2):218-223 | The study of zebrafish, a leading model organism for developmental biology, is rapidly expanding ... | Zebrafish: From disease modeling to drug discovery | | |
| Summerton J | In: Peptide Nucleic Acids, Morpholinos, and Related Antisense Biomolecules. Janson C. and During... | | Morpholinos and PNAs Compared | | |
| Pannier AK, Arora V, Iversen PL, Brand RM | Int J Pharm. 2004 May 4;275(1-2):217-26. | The skin is the largest organ in the body and an obvious route for both local and systemic drug d... | Transdermal delivery of phosphorodiamidate Morpholino oligomers across hairless mouse skin. | | |
| Devi GR | Drug News Perspect. 2004 Mar;17(2):127-34 | Progression to androgen independence combined with chemotherapy resistance remains one of the pri... | XIAP as target for therapeutic apoptosis in prostate cancer | | |
| Iversen PL, Kipshidze N, Moses JW, Leon MB | Methods Mol Med. 2004;106:37-50 | In 1977, percutaneous transluminal coronary angioplasty (PTCA) was first introduced, and it has b... | Local application of antisense for prevention of restenosis | | |
| Jubin R | Methods Mol Med. 2004;106:309-22 | Hepatitis C virus (HCV) contains a positive-sense, single-stranded RNA viral genome that encodes ... | Optimizing electroporation conditions for intracellular delivery of morpholino antisense oligonuc... | | |
| Arora V, Devi G, Iversen PL | Current Pharmaceutical Biotechnology 2004, 5(5):431-439 | Antisense technology constitutes development of sequence-specific DNA or RNA analogs that can blo... | Neutrally Charged Phosphorodiamidate Morpholino Antisense Oligomers: Uptake, Efficacy and Pharmac... | | |
| Stephens AC | Curr Opin Mol Ther. 2004 Oct;6(5):551-8 | AVI BioPharma is developing AVI-4126, an antisense oligonucleotide targeted to c-myc mRNA for the... | Technology evaluation: AVI-4126, AVI BioPharma | | |
| Angerer LM, Angerer RC | Methods Cell Biol. 2004;74:699-711 | No abstract available. | Disruption of gene function using antisense morpholinos. | | |
| Ge Q, Stein D, Kroeker A, Iversen P, Chen J | Program and abstracts of the 44th Interscience Conference of Antimicrobial Agents and Chemotherap... | | Inhibition of influenza A virus production in vero cells with morpholino oligomers | | |
| Mahadevan B, Arora V, Schild LJ, Keshava C, Cate ML, Iversen PL, Poirier MC, Weston A, Pereira C,... | Mol Carcinog. 2006 Feb;45(2):118-25. | Tamoxifen (TAM) is widely used in the treatment and prevention of breast cancer. There is clear e... | Reduction in tamoxifen-induced CYP3A2 expression and DNA adducts using antisense technology | | |
| Nishimura DY, Swiderski RE, Searby CC, Berg EM, Ferguson AL, Hennekam R, Merin S, Weleber RG, Bie... | Am J Hum Genet. 2005 Dec;77(6):1021-33. Epub 2005 Oct 26 | Bardet-Biedl syndrome (BBS) is an autosomal recessive, genetically heterogeneous, pleiotropic hum... | Comparative genomics and gene expression analysis identifies BBS9, a new Bardet-Biedl syndrome ge... | | |
| Summerton J and Weller D | Nucleosides Nucleotides 1997; 16: 889-898 | | Antisense properties of morpholino oligomers | | |
| Gemignani F, Sazani P, Morcos P, Kole R | Nucleic Acids Res. 2002 Nov 1;30(21):4592-8 | A T-->G mutation at nucleotide 705 of human beta-globin intron 2 creates an aberrant 5' splice si... | Temperature-dependent splicing of beta-globin pre-mRNA | | |
| Warfield KL, Panchal RG, Aman MJ, Bavari S | Curr Opin Mol Ther. 2006 Apr;8(2):93-103 | Antisense oligomers (ASOs) represent a promising technology to treat viral and bacterial infectio... | Antisense treatments for biothreat agents | | |
| Summerton J | In Advances in Applied Biotechnology Series, Volume 2, Discoveries in Antisense Nucleic Acids. C... | We have devised a class of uncharged sequence-specific nucleic asid-binding oligomers, Neu-Genes(... | Uncharged Nucleic Acid Analogs for Therapeutic and Diagnostic Applications: Oligomers Assembled f... | | |
| Summerton J | Innovations in Pharmaceutical Technology. Sept 2005 | Oligos which bind to complementary RNA sequences are commonly called ‘antisense’ oligos becau... | Morpholino Antisense Oligos: Applications in Biopharmaceutical Research | | |
| Vander-Linden CL | Chem-Bio Defense Quarterly. 2006 3(2):8-9 | First paragraph:
It was February 11, 2004, and the female scientist was working in a Bio-Safety ... | Gene-Specific Ebola Therapies Protect Nonhuman Primates from Lethal Diseases | | |
| Terry M, Walker DD, Ferrari MB | Cell Biochem Biophys. 2006;45(3):265-78 | During myofibrillogenesis, myosin light-chain kinase (MLCK) phosphorylates the regulatory light c... | Protein phosphatase activity is necessary for myofibrillogenesis | | |
| Tena JJ, Neto A, de la Calle-Mustienes E, Bras-Pereira C, Casares F, Gomez-Skarmeta JL | Dev Biol. 2007 Jan 15;301(2):518-31. Epub 2006 Sep 1. | Odd-skipped family of proteins (Odd in Drosophila and Osr in vertebrates) are evolutionarily cons... | Odd-skipped genes encode repressors that control kidney development | | |
| Wu X, Zhong H, Song J, Damoiseaux R, Yang Z, Lin S | Arterioscler Thromb Vasc Biol. 2006 Oct;26(10):2414-6 | No abstract available | Mycophenolic acid is a potent inhibitor of angiogenesis | | |
| Sample R, Bryan L, Long S, Majji S, Hoskins G, Sinning A, Olivier J, Chinchar VG | Virology. 2007 Feb 20;358(2):311-20. Epub 2006 Oct 3. | Frog virus 3 (FV3) is a large DNA virus that encodes approximately 100 proteins. Although the gen... | Inhibition of iridovirus protein synthesis and virus replication by antisense morpholino oligonuc... | Endo-Porter | |
| Pache G, Schafer C, Wiesemann S, Springer E, Liebau M, Reinhardt HC, August C, Pavenstadt H, Bek ... | Am J Physiol Renal Physiol. 2006 Sep;291(3):F654-62. Epub 2006 Apr 18 | Bone morphogenetic proteins (BMPs) are secreted signaling molecules, which play a major role in k... | Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes | | |
| Schorpp M, Bialecki M, Diekhoff D, Walderich B, Odenthal J, Maischein HM, Zapata AG, Boehm T | J Immunol. 2006 Aug 15;177(4):2463-76 | Zebrafish has been advocated as an alternative animal model to study lymphocyte development, alth... | Conserved functions of Ikaros in vertebrate lymphocyte development: genetic evidence for distinct... | | |
| Wilson BD, Ii M, Park KW, Suli A, Sorensen LK, Larrieu-Lahargue F, Urness LD, Suh W, Asai J, Kock... | Science. 2006 Aug 4;313(5787):640-4. Epub 2006 Jun 29 | Axonal guidance and vascular patterning share several guidance cues, including proteins in the ne... | Netrins promote developmental and therapeutic angiogenesis | | |
| Neuman BW, Stein DA, Kroeker AD, Moulton HM, Bestwick RK, Iversen PL, Buchmeier MJ | Adv Exp Med Biol. 2006;581:567-71 | No abstract available.
| Inhibition and escape of SARS-CoV treated with antisense morpholino oligomers | | |
| Asai-Coakwell M, French CR, Berry KM, Ye M, Koss R, Somerville M, Mueller R, van Heyningen V, Was... | Am J Hum Genet. 2007 Feb;80(2):306-15. Epub 2006 Dec 29 | Colobomata represent visually impairing ocular closure defects that are associated with a diverse... | GDF6, a Novel Locus for a Spectrum of Ocular Developmental Anomalies | | |
| Bani-Yaghoub M, Kubu CJ, Cowling R, Rochira J, Nikopoulos GN, Bellum S, Verdi JM | Dev Dyn. 2007 Mar;236(3):696-705. | Loss of numb function suggests that numb maintains progenitors in an undifferentiated state. Here... | A switch in numb isoforms is a critical step in cortical development | | |
