Citation:
J Allergy Clin Immunol. 2017;[Epub ahead of print] doi:10.1016/j.jaci.2017.02.002
Abstract:
An adult with hypomorphic ZAP-70 deficiency due to de novo donor splice site mutation manifested autoimmunity, infections especially with DNA-based viruses and lymphoproliferation. Morpholino interference of mutant splice site increased expression of wild-type protein, significantly improving T cell responses.
Epub:
Yes
Link to Publication:
http://www.jacionline.org/article/S0091-6749(17)30240-3/pdf