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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9231 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Lysine demethylase 3a in craniofacial and neural development during Xenopus embryogenesis

Authors:
Lee H-K, Ismail T, Kim C, Kim Y, Park J-W, Kwon O-S, Kang B-S, Lee D-S, Kwon T, Park TJ, Lee H-S
Citation:
Int J Molec Med. 2018;[Epub] doi:10.3892/ijmm.2018.4024
Abstract:
Epigenetic modifier lysine demethylase 3a (Kdm3a) specifically demethylates mono‑ and di‑methylated ninth lysine of histone 3...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Lee H-K, Ismail T, Kim C, Kim Y, Park J-W, Kwon O-S, Kang B-S, Lee D-S, Kwon T, Park TJ, Lee H-S. Lysine demethylase 3a in craniofacial and neural development during Xenopus embryogenesis. Int J Molec Med. 2018;[Epub] doi:10.3892/ijmm.2018.4024.

Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins

Authors:
Hsieh CS, Tsai CT, Chen YH, Chang SN, Hwang JJ, Chuang EY, Wu IH
Citation:
J Clin Med. 2018 Dec 11;7(12). pii: E537. doi: 10.3390/jcm7120537
Abstract:
Lower extremities varicose veins (VV) are among the most easily recognized venous abnormalities. The genetic mechanism of VV is...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hsieh CS, Tsai CT, Chen YH, Chang SN, Hwang JJ, Chuang EY, Wu IH. Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins. J Clin Med. 2018 Dec 11;7(12). pii: E537. doi: 10.3390/jcm7120537.

The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis

Authors:
Di Giaimo R, Durovic T, Barquin P, Kociaj A, Lepko T, Aschenbroich S, Breunig CT, Irmler M, Cernilogar FM, Schotta G, Barbosa JS, Tr€umbach D, Baumgart EV, Neuner AM, Beckers J, Wurst W, Stricker SH, Ninkovic J
Citation:
Cell Rep. 2018;25(12):P3241-3251.e5. doi:10.1016/j.celrep.2018.11.055
Abstract:
Zebrafish have a high capacity to replace lost neurons after brain injury. New neurons involved in repair are generated by a...
Delivery Method:
intacerebroventricular (icv) injection
Organism or Cell Type:
zebrafish
Citation Extract:
Di Giaimo R, Durovic T, Barquin P, Kociaj A, Lepko T, Aschenbroich S, Breunig CT, Irmler M, Cernilogar FM, Schotta G, Barbosa JS, Tr€umbach D, Baumgart EV, Neuner AM, Beckers J, Wurst W, Stricker SH, Ninkovic J. The Aryl Hydrocarbon Receptor Pathway Defines the Time Frame for Restorative Neurogenesis. Cell Rep. 2018;25(12):P3241-3251.e5. doi:10.1016/j.celrep.2018.11.055.

Interference of DNAJB6/MRJ Isoform Switch by Morpholino Inhibits Replication of HIV-1 and RSV

Authors:
Ko S-H, Liau Y-J, Chi Y-H, Lai M-J, Chiang Y-P, Lu C-Y, Chang L-Y, Tarn W-Y, Huang L-M
Citation:
Molec Ther Nucl Acids. 2018;[Epub] doi:10.1016/j.omtn.2018.12.001
Abstract:
The molecular chaperon MRJ (DNAJB6) exhibits two splice isoforms that have different roles in human viral infection, but the...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: HEK293T, THP-1, & Hep2
Citation Extract:
Ko S-H, Liau Y-J, Chi Y-H, Lai M-J, Chiang Y-P, Lu C-Y, Chang L-Y, Tarn W-Y, Huang L-M. Interference of DNAJB6/MRJ Isoform Switch by Morpholino Inhibits Replication of HIV-1 and RSV. Molec Ther Nucl Acids. 2018;[Epub] doi:10.1016/j.omtn.2018.12.001.

Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand-independent functions

Authors:
Annalora AJ, Jozic M, Marcus CB, Iversen PL
Citation:
Toxicol Appl Pharmacol. 2018 Dec 12. pii: S0041-008X(18)30547-7. doi: 10.1016/j.taap.2018.12.009. [Epub ahead of print]
Abstract:
Alternative splicing modulates gene function by creating splice variants with alternate functions or non-coding RNA activity....
Organism or Cell Type:
cell culture
Citation Extract:
Annalora AJ, Jozic M, Marcus CB, Iversen PL. Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand-independent functions. Toxicol Appl Pharmacol. 2018 Dec 12. pii: S0041-008X(18)30547-7. doi: 10.1016/j.taap.2018.12.009. [Epub ahead of print].

The Spatio-Temporal Control of Zygotic Genome Activation

Authors:
Gentsch G, Owens NDL, Smith JC
Citation:
bioRxiv. 2018;[Preprint] doi:10.1101/488056
Abstract:
One of the earliest events in embryonic development is zygotic genome activation (ZGA). According to nascent transcript...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Gentsch G, Owens NDL, Smith JC. The Spatio-Temporal Control of Zygotic Genome Activation. bioRxiv. 2018;[Preprint] doi:10.1101/488056.

Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD

Authors:
Coenen-Stass AML, Sork H, Gatto S, Godfrey C, Bhomra A, Krjutškov K, Hart JR, Westholm JO, O'Donovan L, Roos A, Lochmüller H, Puri PL, El Andaloussi S, Wood MJA, Roberts TC
Citation:
Mol Ther Nucleic Acids. 2018 Dec 7;13:1-15. doi: 10.1016/j.omtn.2018.08.005. Epub 2018 Aug 17
Abstract:
Extracellular small RNAs (sRNAs), including microRNAs (miRNAs), are promising biomarkers for diseases such as Duchenne muscular...
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Coenen-Stass AML, Sork H, Gatto S, Godfrey C, Bhomra A, Krjutškov K, Hart JR, Westholm JO, O'Donovan L, Roos A, Lochmüller H, Puri PL, El Andaloussi S, Wood MJA, Roberts TC. Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD. Mol Ther Nucleic Acids. 2018 Dec 7;13:1-15. doi: 10.1016/j.omtn.2018.08.005. Epub 2018 Aug 17.

Non-invasive monitoring of alternative splicing outcomes to identify candidate therapies for myotonic dystrophy type 1

Authors:
Hu N, Antoury L, Baran TM, Mitra S, Bennett CF, Rigo F, Foster TH, Wheeler TM
Citation:
Nat Commun. 2018 Dec 7;9(1):5227. doi: 10.1038/s41467-018-07517-y
Abstract:
During drug development, tissue samples serve as indicators of disease activity and pharmacodynamic responses. Reliable non-...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Hu N, Antoury L, Baran TM, Mitra S, Bennett CF, Rigo F, Foster TH, Wheeler TM. Non-invasive monitoring of alternative splicing outcomes to identify candidate therapies for myotonic dystrophy type 1. Nat Commun. 2018 Dec 7;9(1):5227. doi: 10.1038/s41467-018-07517-y.

Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model

Authors:
Zheng YM, Chen B, Jiang JD, Zhang JP
Citation:
Front Mol Neurosci. 2018 Nov 26;11:378. doi: 10.3389/fnmol.2018.00378. eCollection 2018
Abstract:
Epilepsy is a neuronal dysfunction syndrome characterized by transient and diffusely abnormal discharges of neurons in the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zheng YM, Chen B, Jiang JD, Zhang JP. Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model. Front Mol Neurosci. 2018 Nov 26;11:378. doi: 10.3389/fnmol.2018.00378. eCollection 2018.

A transcriptomics analysis of the Tbx5 paralogues in zebrafish

Authors:
Boyle Anderson EAT, Ho RK
Citation:
PLoS ONE. 2018;13(12):e0208766. doi:10.1371/journal.pone.0208766
Abstract:
TBX5 is essential for limb and heart development. Mutations in TBX5 are associated with Holt-Oram syndrome in humans. Due to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Boyle Anderson EAT, Ho RK. A transcriptomics analysis of the Tbx5 paralogues in zebrafish. PLoS ONE. 2018;13(12):e0208766. doi:10.1371/journal.pone.0208766.

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