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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12092 scientific papers returned from the database with the search filters currently being used below.
There are 12092 scientific papers returned from the database with the search filters currently being used below.
Zebrafish live imaging reveals only around 2% rather than 50% of motor neurons die through apoptosis during development
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Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.26.577434 Epub:
Not Epub Abstract:
It is widely accepted that neurons will die through apoptosis if they cannot receive enough growth factors during development... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Jia H, Yang H, Luo K. Zebrafish live imaging reveals only around 2% rather than 50% of motor neurons die through apoptosis during development. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.26.577434. |
Leucine-rich repeat in polycystin-1 suppresses cystogenesis in a zebrafish (Danio rerio) model of autosomal dominant polycystic kidney disease
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Citation:
Preprints. 2024;2024011959 [preprint]. doi:10.20944/preprints202401.1959.v1 Epub:
Not Epub Abstract:
Mutations of PKD1 coding for polycystin-1 (PC1) account for most of the autosomal dominant polycystic kidney disease (ADPKD).... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Padhy B, Amir M, Xie J, Huang C. Leucine-rich repeat in polycystin-1 suppresses cystogenesis in a zebrafish (Danio rerio) model of autosomal dominant polycystic kidney disease. Preprints. 2024;2024011959 [preprint]. doi:10.20944/preprints202401.1959.v1. |
Characterization of CD90/Thy-1 as a crucial molecular signature for myogenic differentiation in human urine-derived cells through single-cell RNA sequencing
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Citation:
Sci Rep. 2024 Jan 28;14(1):2329. doi: 10.1038/s41598-024-52530-5 Epub:
Not Epub Abstract:
Human urine-derived cells (UDCs) are primary cultured cells originating from the upper urinary tract and are known to be... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: Human CD90-positive MYOD1-urine-derived cells Citation Extract: Kunitake K, Motohashi N, Inoue T, Suzuki Y, Aoki Y. Characterization of CD90/Thy-1 as a crucial molecular signature for myogenic differentiation in human urine-derived cells through single-cell RNA sequencing. Sci Rep. 2024 Jan 28;14(1):2329. doi: 10.1038/s41598-024-52530-5. |
A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish
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Citation:
Biochem Biophys Res Commun. 2024 Jan 19;699:149551. doi: 10.1016/j.bbrc.2024.149551. Online ahead of print Epub:
Not Epub Abstract:
V-ATPase is an ATP hydrolysis-driven proton pump involved in the acidification of intracellular organelles and systemic acid-... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ikeuchi M, Inoue M, Miyahara H, Sebastian WA, Miyazaki S, Takeno T, Kiyota K, Yano S, Shiraishi H, Shimizu N, Hanada R, Yoshimura A, Ihara K, Hanada T. A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish. Biochem Biophys Res Commun. 2024 Jan 19;699:149551. doi: 10.1016/j.bbrc.2024.149551. Online ahead of print. |
Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity
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Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.25.576046 Epub:
Not Epub Abstract:
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease characterized by the development of arteriovenous... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Anzell AR, Kunz AB, Donovan JP, Tran TG, Lu X, Young S, Roman BL. Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.25.576046. |
Systemic delivery of a splice-switching oligonucleotide heteroduplex corrects splicing in central nervous system and muscle in spinal muscular atrophy mice
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Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.24.577012 Epub:
Not Epub Abstract:
Oligonucleotide therapeutics are an established class of drugs for the treatment of genetic disorders. Their clinical... Delivery Method:
heteroduplex oligonucleotide (HDO) platform Organism or Cell Type:
cell culture: SMA Type II patient fibroblasts, hSMN2 mouse Citation Extract: Halloy F, Ahlskog N, Wood M. Systemic delivery of a splice-switching oligonucleotide heteroduplex corrects splicing in central nervous system and muscle in spinal muscular atrophy mice. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.24.577012. |
Perturbed development of calb2b expressing dI6 interneurons and motor neurons underlies locomotor defects observed in calretinin knock-down zebrafish larvae
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Citation:
Dev Biol. 2024;508:77-87. doi:10.1016/j.ydbio.2024.01.001 Epub:
Not Epub Abstract:
Calcium binding proteins are essential for neural development and cellular activity. Calretinin, encoded by calb2a and calb2b,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Gonzalez ABI, Koning HK, Tuz-Sasik MU, van Osselen I, Manuel R, Boije H. Perturbed development of calb2b expressing dI6 interneurons and motor neurons underlies locomotor defects observed in calretinin knock-down zebrafish larvae. Dev Biol. 2024;508:77-87. doi:10.1016/j.ydbio.2024.01.001. |
An anti-sense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo
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Citation:
Am J Physiol Heart Circ Physiol. 2024 Jan 26. doi: 10.1152/ajpheart.00745.2023. Online ahead of print Epub:
Yes Abstract:
Targeting alternative exons for therapeutic gain has been achieved in a few instances and potentially could be applied more... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
mice Citation Extract: Damacena de Angelis C, Meddeb M, Chen N, Fisher SA. An anti-sense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo. Am J Physiol Heart Circ Physiol. 2024 Jan 26. doi: 10.1152/ajpheart.00745.2023. Online ahead of print. |
Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring
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Citation:
Cells. 2024;13:214. doi:10.3390/cells13030214 Epub:
Not Epub Abstract:
Elevation of the intermediate amino acid metabolite Homocysteine (Hcy) causes Hyperhomocysteinemia (HHcy), a metabolic disorder... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chatterje B, Fatima F, Seth S, Sinha Roy S. Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring. Cells. 2024;13:214. doi:10.3390/cells13030214. |
TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish
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Citation:
Front Cell Neurosci. 2024;18:[Epub] doi:10.3389/fncel.2024.1340240 Epub:
Yes Abstract:
Disease-associated variants of TUBA4A (alpha-tubulin 4A) have recently been identified in familial ALS. Interestingly, a... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Van Schoor E, Strubbe D, Braems E, Weishaupt J, Ludolph A, Van Damme P, Thal DR, Bercier V, Van Den Bosch L. TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish. Front Cell Neurosci. 2024;18:[Epub] doi:10.3389/fncel.2024.1340240. |