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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12067 scientific papers returned from the database with the search filters currently being used below.

BMPER is a conserved regulator of hematopoietic and vascular development in zebrafish

Authors:
Moser M, Yu Q, Bode C, Xiong JW, Patterson C
Citation:
J Mol Cell Cardiol. 2007 Sep;43(3):243-53. Epub 2007 May 18
Epub:
Not Epub
Abstract:
For the proper development of vertebrate embryos as well as for survival of the adult organism, it is essential to form a...
Organism or Cell Type:
zebrafish
Citation Extract:
Moser M, Yu Q, Bode C, Xiong JW, Patterson C. BMPER is a conserved regulator of hematopoietic and vascular development in zebrafish. J Mol Cell Cardiol. 2007 Sep;43(3):243-53. Epub 2007 May 18.

Brain induction in ascidian embryos is dependent on juxtaposition of FGF9/16/20-producing and -receiving cells

Authors:
Miyazaki Y, Nishida H, Kumano G
Citation:
Dev Genes Evol. 2007 Mar;217(3):177-88. Epub 2007 Jan 11
Epub:
Not Epub
Abstract:
Coordinated regulation of inductive events, both spatially and temporally, during animal development ensures that tissues are...
Delivery Method:
Microinjection
Organism or Cell Type:
Halocynthia roretzi (ascidian)
Citation Extract:
Miyazaki Y, Nishida H, Kumano G. Brain induction in ascidian embryos is dependent on juxtaposition of FGF9/16/20-producing and -receiving cells. Dev Genes Evol. 2007 Mar;217(3):177-88. Epub 2007 Jan 11.

By-passing the nonsense mutation in the 4(CV) mouse model of muscular dystrophy by induced exon skipping

Authors:
Mitrpant C, Fletcher S, Iversen PL, Wilton SD
Citation:
J Gene Med. 2008 Nov 12. [Epub ahead of print]
Epub:
Not Epub
Abstract:
BACKGROUND: Duchenne muscular dystrophy (DMD), a severe neuromuscular disorder, is caused by protein-truncating mutations in...
Delivery Method:
Injection
Organism or Cell Type:
Mouse, mdx-4Cv
Citation Extract:
Mitrpant C, Fletcher S, Iversen PL, Wilton SD. By-passing the nonsense mutation in the 4(CV) mouse model of muscular dystrophy by induced exon skipping. J Gene Med. 2008 Nov 12. [Epub ahead of print].

Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo

Authors:
Moulton HM, Fletcher S, Neuman BW, McClorey G, Stein DA, Abes S, Wilton SD, Buchmeier MJ, Lebleu B, Iversen PL
Citation:
Biochem Soc Trans. 2007 Aug;35(Pt 4):826-8
Epub:
Not Epub
Abstract:
The cellular uptake of PMOs (phosphorodiamidate morpholino oligomers) can be enhanced by their conjugation to arginine-rich...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice (mdx), dog myoblasts
Citation Extract:
Moulton HM, Fletcher S, Neuman BW, McClorey G, Stein DA, Abes S, Wilton SD, Buchmeier MJ, Lebleu B, Iversen PL. Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo. Biochem Soc Trans. 2007 Aug;35(Pt 4):826-8.

Cell-penetrating peptides enhance systemic delivery of antisense morpholino oligomers

Authors:
Moulton HM
Citation:
Methods Mol Biol. 2012;867:407-14
Epub:
Not Epub
Abstract:
Exon-skipping efficacy of phosphorodiamidate morpholino oligomers (Morpholinos) has been demonstrated in a proof-of-concept...
Delivery Method:
peptide-coupled
Organism or Cell Type:
mice, mdx and utrophin/dystrophin dKO
Citation Extract:
Moulton HM. Cell-penetrating peptides enhance systemic delivery of antisense morpholino oligomers. Methods Mol Biol. 2012;867:407-14.

Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides

Authors:
Moulton HM, Nelson MH, Hatlevig SA, Reddy MT, Iversen PL
Citation:
Bioconjug Chem. 2004 Mar-Apr;15(2):290-9
Epub:
Not Epub
Abstract:
Although the sequence specificity, biostability, and low toxicity of PMO (phosphorodiamidate morpholino oligomers) make them...
Delivery Method:
peptide-coupled
Organism or Cell Type:
cell culture: HeLa pLuc705 and NIH-3T3 cells
Citation Extract:
Moulton HM, Nelson MH, Hatlevig SA, Reddy MT, Iversen PL. Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides. Bioconjug Chem. 2004 Mar-Apr;15(2):290-9.

CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development

Authors:
Mochida GH, Ganesh VS, de Michelena MI, Dias H, Atabay KD, Kathrein KL, Huang HT, Hill RS, Felie JM, Rakiec D, Gleason D, Hill AD, Malik AN, Barry BJ, Partlow JN, Tan WH, Glader LJ, Barkovich AJ, Dobyns WB, Zon LI, Walsh CA
Citation:
Nat Genet. 2012 Sep 30. doi: 10.1038/ng.2425. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Charged multivesicular body protein 1A (CHMP1A; also known as chromatin-modifying protein 1A) is a member of the ESCRT-III (...
Delivery Method:
Microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mochida GH, Ganesh VS, de Michelena MI, Dias H, Atabay KD, Kathrein KL, Huang HT, Hill RS, Felie JM, Rakiec D, Gleason D, Hill AD, Malik AN, Barry BJ, Partlow JN, Tan WH, Glader LJ, Barkovich AJ, Dobyns WB, Zon LI, Walsh CA. CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Nat Genet. 2012 Sep 30. doi: 10.1038/ng.2425. [Epub ahead of print].

Chondroitin 4-O-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish

Authors:
Mizumoto S, Mikami T, Yasunaga D, Kobayashi N, Yamauchi H, Miyake A, Itoh N, Kitagawa H, Sugahara K
Citation:
Biochem J. 2009 Jan 6. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Chondroitin sulfate (CS) has been implicated in a variety of biological processes during development. Its biological functions...
Organism or Cell Type:
zebrafish
Citation Extract:
Mizumoto S, Mikami T, Yasunaga D, Kobayashi N, Yamauchi H, Miyake A, Itoh N, Kitagawa H, Sugahara K. Chondroitin 4-O-sulfotransferase-1 is required for somitic muscle development and motor axon guidance in zebrafish. Biochem J. 2009 Jan 6. [Epub ahead of print].

Chordin affects pronephros development in Xenopus embryos by anteriorizing presomitic mesoderm.

Authors:
Mitchell T, Jones EA, Weeks DL, Sheets MD
Citation:
Dev Dyn. 2007 Jan;236(1):251-61.
Epub:
Not Epub
Abstract:
Spemann's organizer emits signals that pattern the mesodermal germ layer during Xenopus embryogenesis. In a previous study...
Delivery Method:
Microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Mitchell T, Jones EA, Weeks DL, Sheets MD. Chordin affects pronephros development in Xenopus embryos by anteriorizing presomitic mesoderm.. Dev Dyn. 2007 Jan;236(1):251-61..

Cofilin is required for organization of sarcomeric actin filaments in chicken skeletal muscle cells

Authors:
Miyauchi-Nomura S, Obinata T, Sato N
Citation:
Cytoskeleton (Hoboken). 2012 Mar 6. doi: 10.1002/cm.21025. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Cofilin is an actin regulatory protein that plays a critical role in actin filament dynamics in a variety of cells. We have...
Delivery Method:
Microinjection
Organism or Cell Type:
cell culture: chick skeletal myotubes
Citation Extract:
Miyauchi-Nomura S, Obinata T, Sato N. Cofilin is required for organization of sarcomeric actin filaments in chicken skeletal muscle cells. Cytoskeleton (Hoboken). 2012 Mar 6. doi: 10.1002/cm.21025. [Epub ahead of print].

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