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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12067 scientific papers returned from the database with the search filters currently being used below.

Systemic delivery of a splice-switching oligonucleotide heteroduplex corrects splicing in central nervous system and muscle in spinal muscular atrophy mice

Authors:
Halloy F, Ahlskog N, Wood M
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.24.577012
Epub:
Not Epub
Abstract:
Oligonucleotide therapeutics are an established class of drugs for the treatment of genetic disorders. Their clinical...
Delivery Method:
heteroduplex oligonucleotide (HDO) platform
Organism or Cell Type:
cell culture: SMA Type II patient fibroblasts, hSMN2 mouse
Citation Extract:
Halloy F, Ahlskog N, Wood M. Systemic delivery of a splice-switching oligonucleotide heteroduplex corrects splicing in central nervous system and muscle in spinal muscular atrophy mice. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.24.577012.

Perturbed development of calb2b expressing dI6 interneurons and motor neurons underlies locomotor defects observed in calretinin knock-down zebrafish larvae

Authors:
Gonzalez ABI, Koning HK, Tuz-Sasik MU, van Osselen I, Manuel R, Boije H
Citation:
Dev Biol. 2024;508:77-87. doi:10.1016/j.ydbio.2024.01.001
Epub:
Not Epub
Abstract:
Calcium binding proteins are essential for neural development and cellular activity. Calretinin, encoded by calb2a and calb2b,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gonzalez ABI, Koning HK, Tuz-Sasik MU, van Osselen I, Manuel R, Boije H. Perturbed development of calb2b expressing dI6 interneurons and motor neurons underlies locomotor defects observed in calretinin knock-down zebrafish larvae. Dev Biol. 2024;508:77-87. doi:10.1016/j.ydbio.2024.01.001.

An anti-sense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo

Authors:
Damacena de Angelis C, Meddeb M, Chen N, Fisher SA
Citation:
Am J Physiol Heart Circ Physiol. 2024 Jan 26. doi: 10.1152/ajpheart.00745.2023. Online ahead of print
Epub:
Yes
Abstract:
Targeting alternative exons for therapeutic gain has been achieved in a few instances and potentially could be applied more...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Damacena de Angelis C, Meddeb M, Chen N, Fisher SA. An anti-sense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo. Am J Physiol Heart Circ Physiol. 2024 Jan 26. doi: 10.1152/ajpheart.00745.2023. Online ahead of print.

Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring

Authors:
Chatterje B, Fatima F, Seth S, Sinha Roy S
Citation:
Cells. 2024;13:214. doi:10.3390/cells13030214
Epub:
Not Epub
Abstract:
Elevation of the intermediate amino acid metabolite Homocysteine (Hcy) causes Hyperhomocysteinemia (HHcy), a metabolic disorder...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chatterje B, Fatima F, Seth S, Sinha Roy S. Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring. Cells. 2024;13:214. doi:10.3390/cells13030214.

TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish

Authors:
Van Schoor E, Strubbe D, Braems E, Weishaupt J, Ludolph A, Van Damme P, Thal DR, Bercier V, Van Den Bosch L
Citation:
Front Cell Neurosci. 2024;18:[Epub] doi:10.3389/fncel.2024.1340240
Epub:
Yes
Abstract:
Disease-associated variants of TUBA4A (alpha-tubulin 4A) have recently been identified in familial ALS. Interestingly, a...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Van Schoor E, Strubbe D, Braems E, Weishaupt J, Ludolph A, Van Damme P, Thal DR, Bercier V, Van Den Bosch L. TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish. Front Cell Neurosci. 2024;18:[Epub] doi:10.3389/fncel.2024.1340240.

Deficiency of copper responsive gene stmn4 induces retinal developmental defects

Authors:
Jing Y, Luo Y, Li L, Liu M, Liu JX
Citation:
Cell Biol Toxicol. 2024 Jan 22;40(1):2. doi: 10.1007/s10565-024-09847-8
Epub:
Not Epub
Abstract:
As part of the central nervous system (CNS), the retina senses light and also conducts and processes visual impulses. The...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jing Y, Luo Y, Li L, Liu M, Liu JX. Deficiency of copper responsive gene stmn4 induces retinal developmental defects. Cell Biol Toxicol. 2024 Jan 22;40(1):2. doi: 10.1007/s10565-024-09847-8.

The Effect of Morpholino Oligonucleotides to Gene Anxa2a on the Embryonic Development of Danio rerio

Authors:
Partevian SA, Safina DR, Rudenok MM, Rybolovlev IN, Semenova EI, Shadrina MI, Slominsky PA, Kostrov SV, Alieva AKh
Citation:
Mol Gen Microbiol Virol. 2024;38:143-9. doi:10.3103/S0891416823030059
Epub:
Not Epub
Abstract:
The Annexin 2 protein (ANXA2) encoded by the ANXA2 gene performs a number of biological functions that are primarily related to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Partevian SA, Safina DR, Rudenok MM, Rybolovlev IN, Semenova EI, Shadrina MI, Slominsky PA, Kostrov SV, Alieva AKh. The Effect of Morpholino Oligonucleotides to Gene Anxa2a on the Embryonic Development of Danio rerio. Mol Gen Microbiol Virol. 2024;38:143-9. doi:10.3103/S0891416823030059.

Epileptic phenotypes in slc13a5 loss-of-function zebrafish are rescued by blocking NMDA receptor signaling

Authors:
Dogra D, Phan VA, Gavrilovici C, DiMarzo N, Ibhazehiebo K, Kurrasch DM
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.15.575806
Epub:
Not Epub
Abstract:
SLC13A5 encodes a citrate transporter highly expressed in the brain important for regulating intra- and extracellular citrate...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dogra D, Phan VA, Gavrilovici C, DiMarzo N, Ibhazehiebo K, Kurrasch DM. Epileptic phenotypes in slc13a5 loss-of-function zebrafish are rescued by blocking NMDA receptor signaling. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.15.575806.

Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production

Authors:
Li Y, Li X, Ye D, Zhang R, Liu C, He M, Wang H, Hu W, Sun Y
Citation:
Zool Res. 2024 Jan 18;45(1):176-188. doi: 10.24272/j.issn.2095-8137.2023.032
Epub:
Not Epub
Abstract:
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), particularly docosahexaenoic acid (22:6n-3, DHA), play crucial roles in the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li Y, Li X, Ye D, Zhang R, Liu C, He M, Wang H, Hu W, Sun Y. Endogenous biosynthesis of docosahexaenoic acid (DHA) regulates fish oocyte maturation by promoting pregnenolone production. Zool Res. 2024 Jan 18;45(1):176-188. doi: 10.24272/j.issn.2095-8137.2023.032.

Ciliary length regulation by intraflagellar transport in zebrafish

Authors:
Sun Y, Chen Z, Jin M, Xie H, Zhao C
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.16.575975
Epub:
Not Epub
Abstract:
How cells regulate the size of their organelles remains a fundamental question in cell biology. Cilia, with their simple...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sun Y, Chen Z, Jin M, Xie H, Zhao C. Ciliary length regulation by intraflagellar transport in zebrafish. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.16.575975.

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