The diagnostics program at Gene Tools is pursuing development of two products: a small-molecule reagent to enhance imaging of tumors and a Morpholino-based diagnostic reagent & instrumentation package for detection of infectious agents. Gene Tools holds exclusive rights to the use of Morpholinos in diagnostics.

Contact: Dr. Jon Moulton, Diagnostics and Special Projects

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Here are some references which might be useful to investigators considering using Morpholinos in probe diagnostics systems:

Gong P, Wang K, Liu Y, Shepard K, Levicky R. Molecular Mechanisms in Morpholino-DNA Surface Hybridization. J Am Chem Soc. 2010 Jun 24. [Epub ahead of print]

Zhang GJ, Luo ZH, Huang MJ, Tay GK, Lim EJ. Morpholino-functionalized silicon nanowire biosensor for sequence-specific label-free detection of DNA. Biosens Bioelectron. 2010 Apr 9. [Epub ahead of print]

Tercero N, Wang K, Gong P, Levicky R. Morpholino Monolayers: Preparation and Label-free DNA Analysis by Surface Hybridization. J Am Chem Soc. 2009 Mar 18. [Epub ahead of print]

Wang X, Smirnov S. Label-Free DNA Sensor Based on Surface Charge Modulated Ionic Conductance. ACS Nano. 2009 Mar 13. [Epub ahead of print]

Gao Z, Boon PT. A DNA biosensor based on a morpholino oligomer coated indium-tin oxide electrode and a cationic redox polymer. Analyst. 2009; [Epub ahead of print]

Wages JM Jr; Wages GM; Matthews P; Weller D; Summerton J. Affinity purification of RNA: sequence-specific capture by nonionic morpholino probes. Biotechniques. 1997 Dec;23(6):1116-21.