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Morpholinos in bacteria

Morpholinos have been used to knock down gene expression in various bacteria. Here is a citation list.

Geller BL, Greenberg DE. Peptide-conjugated phosphorodiamidate morpholino oligomers: a new strategy for tackling antibiotic resistance. Ther Deliv. 2014 Mar;5(3):243-5. doi: 10.4155/tde.13.145. No abstract available.

Sawyer AJ, Wesolowski D, Gandotra N, Stojadinovic A, Izadjoo M, Altman S, Kyriakides TR. A peptide-morpholino oligomer conjugate targeting Staphylococcus aureus gyrA mRNA improves healing in an infected mouse cutaneous wound model. Int J Pharmaceutics. 2013;[Epub ahead of print] doi:10.1016/j.ijpharm.2013.05.041

Wesolowski D, Alonso D, Altman S. Combined effect of a peptide–morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic. PNAS. 2013; [Epub ahead of print] doi:10.1073/pnas.1306911110

Puckett SE, Reese KA, Mitev GM, Mullen V, Johnson RC, Pomraning KR, Mellbye BL, Tilley LD, Iversen PL, Freitag M, Geller BL. Bacterial Resistance to Antisense Peptide-Phosphorodiamidate Morpholino Oligomers. Antimicrob Agents Chemother. 2012 Sep 17. [Epub ahead of print].

Panchal RG, Geller BL, Mellbye B, Lane D, Iversen PL, Bavari S. Peptide Conjugated Phosphorodiamidate Morpholino Oligomers Increase Survival of Mice Challenged with Ames Bacillus anthracis. Nucleic Acid Ther. 2012 Oct;22(5):316-22. doi: 10.1089/nat.2012.0362. Epub 2012 Sep 14.

Greenberg DE, Marshall-Batty KR, Brinster LR, Zarember KA, Shaw PA, Mellbye BL, Iversen PL, Holland SM, Geller BL. Antisense Phosphorodiamidate Morpholino Oligomers Targeted to an Essential Gene Inhibit Burkholderia cepacia Complex. J Infect Dis. 2010 May 3. [Epub ahead of print]

Mellbye BL, Weller DD, Hassinger JN, Reeves MD, Lovejoy CE, Iversen PL, Geller BL. Cationic phosphorodiamidate morpholino oligomers efficiently prevent growth of Escherichia coli in vitro and in vivo. J Antimicrob Chemother. 2009 Nov 1. [Epub ahead of print]

Mitev GM, Mellbye BL, Iversen PL, Geller BL. Inhibition of Intracellular Growth of Salmonella enterica serovar typhimurium in Tissue Culture by Antisense Peptide-Phosphorodiamidate Morpholino Oligomer. Antimicrob Agents Chemother. 2009 Jul 6. [Epub ahead of print]

Shen N, Ko JH, Xiao G, Wesolowski D, Shan G, Geller B, Izadjoo M, Altman S. Inactivation of expression of several genes in a variety of bacterial species by EGS technology. Proc Natl Acad Sci U S A. 2009 Apr 30. [Epub ahead of print]

Mellbye BL, Puckett SE, Tilley LD, Iversen PL, Geller BL. Variations in Amino Acid Composition of Antisense Peptide-Phosphorodiamidate Morpholino Oligomer Affect Potency Against Escherichia coli in vitro and in vivo. Antimicrob Agents Chemother. 2009 Feb;53(2):525-30. Epub 2008 Nov 17.

Tilley LD, Mellbye BL, Puckett SE, Iversen PL, Geller BL. Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli. J Antimicrob Chemother. 2007 Jan;59(1):66-73. Epub 2006 Oct 31.

Tilley LD, Hine OS, Kellogg JA, Hassinger JN, Weller DD, Iversen PL, Geller BL. Gene-Specific Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella enterica Serovar Typhimurium in Pure Culture and in Tissue Culture. Antimicrob Agents Chemother. 2006 Aug;50(8):2789-96.

Deere J, Iversen P, Geller BL. Antisense Phosphorodiamidate Morpholino Oligomer Length and Target Position Effects on Gene-Specific Inhibition in Escherichia coli. Antimicrob Agents Chemother. 2005 Jan;49(1):249-55.

Geller BL, Deere J, Tilley L, Iversen PL. Antisense phosphorodiamidate morpholino oligomer inhibits viability of Escherichia coli in pure culture and in mouse peritonitis. J Antimicrob Chemother. 2005 Jun;55(6):983-8. Epub 2005 May 4.

Geller BL. Antibacterial antisense. Curr Opin Mol Ther 2005 7(2):109-13.

Geller BL, Deere JD, Stein DA, Kroeker AD, Moulton HM, Iversen PL. Inhibition of Gene Expression in Escherichia coli by Antisense Phosphorodiamidate Morpholino Oligomers. Antimicrob Agents Chemother. 2003 Oct;47(10):3233-9.