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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 8799 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Phosphorodiamidate morpholino targeting the 5' untranslated region of the ZIKV RNA inhibits virus replication

Authors:
Popik W, Khatua A, Hildreth JEK, Lee B, Alcendor DJ
Citation:
Virology. 2018 Apr 18;519:77-85. doi: 10.1016/j.virol.2018.04.001. [Epub ahead of print]
Abstract:
BACKGROUND: Zika virus (ZIKV) infection has been associated with microcephaly in infants. Currently there is no treatment or...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: human glomerular podocytes
Citation Extract:
Popik W, Khatua A, Hildreth JEK, Lee B, Alcendor DJ. Phosphorodiamidate morpholino targeting the 5' untranslated region of the ZIKV RNA inhibits virus replication. Virology. 2018 Apr 18;519:77-85. doi: 10.1016/j.virol.2018.04.001. [Epub ahead of print].

Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure

Authors:
Tampe B, Tampe D, Nyamsuren G, Klöpper F, Rapp G, Kauffels A, Lorf T, Zeisberg EM, Müller GA, Kalluri R, Hakroush S, Zeisberg M
Citation:
J Clin Invest. 2018 Apr 17. pii: 89632. doi: 10.1172/JCI89632. [Epub ahead of print]
Abstract:
Progression of chronic kidney disease associated with progressive fibrosis and impaired tubular epithelial regeneration is...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Tampe B, Tampe D, Nyamsuren G, Klöpper F, Rapp G, Kauffels A, Lorf T, Zeisberg EM, Müller GA, Kalluri R, Hakroush S, Zeisberg M. Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure. J Clin Invest. 2018 Apr 17. pii: 89632. doi: 10.1172/JCI89632. [Epub ahead of print].

Etiology and functional validation of gastrointestinal motility dysfunction in a zebrafish model of CHARGE syndrome

Authors:
Cloney K, Steele SL, Stoyek MR, Croll RP, Smith FM, Prykhozhij SV, Brown MM, Midgen C, Blake K, Berman JN
Citation:
FEBS J. 2018 Apr 16. doi: 10.1111/febs.14473. [Epub ahead of print]
Abstract:
CHARGE syndrome is linked to autosomal dominant mutations in the CHD7 gene and results in a number of physiological and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cloney K, Steele SL, Stoyek MR, Croll RP, Smith FM, Prykhozhij SV, Brown MM, Midgen C, Blake K, Berman JN. Etiology and functional validation of gastrointestinal motility dysfunction in a zebrafish model of CHARGE syndrome. FEBS J. 2018 Apr 16. doi: 10.1111/febs.14473. [Epub ahead of print].

Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos

Authors:
Duan J, Liang S, Yu Y, Li Y, Wang L, Wu Z, Chen Y, Miller MR, Sun Z
Citation:
Nanotoxicology. 2018 Apr 14:1-15. doi: 10.1080/17435390.2018.1461267. [Epub ahead of print]
Abstract:
Nowadays, nanotechnology environmental health and safety (nanoEHS) is gaining attention. We previously found that silica...
Organism or Cell Type:
zebrafish
Citation Extract:
Duan J, Liang S, Yu Y, Li Y, Wang L, Wu Z, Chen Y, Miller MR, Sun Z. Inflammation-coagulation response and thrombotic effects induced by silica nanoparticles in zebrafish embryos. Nanotoxicology. 2018 Apr 14:1-15. doi: 10.1080/17435390.2018.1461267. [Epub ahead of print].

Roles of progesterone receptor membrane component 1 and membrane progestin receptor alpha in regulation of zebrafish oocyte maturation

Authors:
Aizen J, Pang Y, Harris C, Converse A, Zhu Y, Aguirre MA, Thomas P
Citation:
Gen Comp Endocrinol. 2018 Apr 9. pii: S0016-6480(17)30757-8. doi: 10.1016/j.ygcen.2018.04.009. [Epub ahead of print]
Abstract:
Although previous studies suggest membrane progesterone receptor alpha (mPRα/Paqr7) mediates 17, 20β-dihydroxy-4-pregnen-3-one...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Aizen J, Pang Y, Harris C, Converse A, Zhu Y, Aguirre MA, Thomas P. Roles of progesterone receptor membrane component 1 and membrane progestin receptor alpha in regulation of zebrafish oocyte maturation. Gen Comp Endocrinol. 2018 Apr 9. pii: S0016-6480(17)30757-8. doi: 10.1016/j.ygcen.2018.04.009. [Epub ahead of print].

Systemic administration of the antisense oligonucleotide NS-065/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy

Authors:
Komaki H, Nagata T, Saito T, Masuda S, Takeshita E, Sasaki M, Tachimori H, Nakamura H, Aoki Y, Takeda S
Citation:
Sci Transl Med. 2018 Apr 18;10(437). pii: eaan0713. doi: 10.1126/scitranslmed.aan0713
Abstract:
Duchenne muscular dystrophy (DMD) is a lethal hereditary muscle disease caused by mutations in the gene encoding the muscle...
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Komaki H, Nagata T, Saito T, Masuda S, Takeshita E, Sasaki M, Tachimori H, Nakamura H, Aoki Y, Takeda S. Systemic administration of the antisense oligonucleotide NS-065/NCNP-01 for skipping of exon 53 in patients with Duchenne muscular dystrophy. Sci Transl Med. 2018 Apr 18;10(437). pii: eaan0713. doi: 10.1126/scitranslmed.aan0713.

Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia

Authors:
Guissart C, Latypova X, Rollier P, Khan TN, Stamberger H, McWalter K, Cho MT, Kjaergaard S, Weckhuysen S, Lesca G, Besnard T, Õunap K, Schema J, Chiocchetti AG, McDonald M, de Bellescize J, Vincent M, Van Esch H, Sattler S, Forghani I, Thiffault I, Freitag CM, Barbouth DS, Cadieux-Dion M, Willaert R, Sacoto MJG, Safina NP, Dubourg C, Grote L, Carré W, Saunders C, Pajusalu S, Farrow E, Boland A, Karlowicz DH, Deleuze J-F, Wojcik MH, Pressman R, Isidor B, Vogels A, Van Paesschen W, Al-Gazali J, Al Shamsi AM, Claustres M, Pujol A, Sanders SJ, Rivier F, Leboucq N, Cogné B, Sasorith S, Sanlaville D, Retterer K, Odent S, Katsanis N, Bézieau S, Koenig M, Davis EE, Pasquier L, Küry S
Citation:
Am J Hum Genet. 2018;[Epub ahead of print] doi:10.1016/j.ajhg.2018.02.021
Abstract:
RORα, the RAR-related orphan nuclear receptor alpha, is essential for cerebellar development. The spontaneous mutant mouse...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Guissart C, Latypova X, Rollier P, Khan TN, Stamberger H, McWalter K, Cho MT, Kjaergaard S, Weckhuysen S, Lesca G, Besnard T, Õunap K, Schema J, Chiocchetti AG, McDonald M, de Bellescize J, Vincent M, Van Esch H, Sattler S, Forghani I, Thiffault I, Freitag CM, Barbouth DS, Cadieux-Dion M, Willaert R, Sacoto MJG, Safina NP, Dubourg C, Grote L, Carré W, Saunders C, Pajusalu S, Farrow E, Boland A, Karlowicz DH, Deleuze J-F, Wojcik MH, Pressman R, Isidor B, Vogels A, Van Paesschen W, Al-Gazali J, Al Shamsi AM, Claustres M, Pujol A, Sanders SJ, Rivier F, Leboucq N, Cogné B, Sasorith S, Sanlaville D, Retterer K, Odent S, Katsanis N, Bézieau S, Koenig M, Davis EE, Pasquier L, Küry S. Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia. Am J Hum Genet. 2018;[Epub ahead of print] doi:10.1016/j.ajhg.2018.02.021.

Calcium Signals Act Through Histone Deacetylase to Mediate Pronephric Kidney Morphogenesis

Authors:
Rothschild SC, Lee HJ, Ingram SR, Mohammadi DK, Walsh GS, Tombes RM
Citation:
Dev Dyn. 2018 Apr 6. doi: 10.1002/dvdy.24632. [Epub ahead of print]
Abstract:
BACKGROUND: Autosomal dominant polycystic kidney disease is the most common monogenetic kidney disorder and is linked to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rothschild SC, Lee HJ, Ingram SR, Mohammadi DK, Walsh GS, Tombes RM. Calcium Signals Act Through Histone Deacetylase to Mediate Pronephric Kidney Morphogenesis. Dev Dyn. 2018 Apr 6. doi: 10.1002/dvdy.24632. [Epub ahead of print].

Synaptically silent sensory hair cells in zebrafish are recruited after damage

Authors:
Zhang Q, Li S, Wong H-TC, He XJ, Beirl A, Petralia RS, Wang Y-X, Kindt KS
Citation:
Nat Comm. 2018;9:1388. doi:10.1038/s41467-018-03806-8
Abstract:
Analysis of mechanotransduction among ensembles of sensory hair cells in vivo is challenging in many species. To overcome this...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang Q, Li S, Wong H-TC, He XJ, Beirl A, Petralia RS, Wang Y-X, Kindt KS. Synaptically silent sensory hair cells in zebrafish are recruited after damage. Nat Comm. 2018;9:1388. doi:10.1038/s41467-018-03806-8.

Blocking variant surface glycoprotein synthesis alters endoplasmic reticulum exit sites/Golgi homeostasis in Trypanosoma brucei

Authors:
Ooi C-P, Smith TK, Gluenz E, Vasileva Wand NV, Vaughan S, Rudenko G
Citation:
Traffic. 2018;[Epub] doi:10.1111/tra.12561
Abstract:
The predominant secretory cargo of bloodstream form Trypanosoma brucei is variant surface glycoprotein (VSG), comprising ~10%...
Delivery Method:
electroporation
Organism or Cell Type:
Trypanosoma brucei
Citation Extract:
Ooi C-P, Smith TK, Gluenz E, Vasileva Wand NV, Vaughan S, Rudenko G. Blocking variant surface glycoprotein synthesis alters endoplasmic reticulum exit sites/Golgi homeostasis in Trypanosoma brucei. Traffic. 2018;[Epub] doi:10.1111/tra.12561.

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