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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9184 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Non-invasive monitoring of alternative splicing outcomes to identify candidate therapies for myotonic dystrophy type 1

Authors:
Hu N, Antoury L, Baran TM, Mitra S, Bennett CF, Rigo F, Foster TH, Wheeler TM
Citation:
Nat Commun. 2018 Dec 7;9(1):5227. doi: 10.1038/s41467-018-07517-y
Abstract:
During drug development, tissue samples serve as indicators of disease activity and pharmacodynamic responses. Reliable non-...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Hu N, Antoury L, Baran TM, Mitra S, Bennett CF, Rigo F, Foster TH, Wheeler TM. Non-invasive monitoring of alternative splicing outcomes to identify candidate therapies for myotonic dystrophy type 1. Nat Commun. 2018 Dec 7;9(1):5227. doi: 10.1038/s41467-018-07517-y.

Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model

Authors:
Zheng YM, Chen B, Jiang JD, Zhang JP
Citation:
Front Mol Neurosci. 2018 Nov 26;11:378. doi: 10.3389/fnmol.2018.00378. eCollection 2018
Abstract:
Epilepsy is a neuronal dysfunction syndrome characterized by transient and diffusely abnormal discharges of neurons in the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zheng YM, Chen B, Jiang JD, Zhang JP. Syntaxin 1B Mediates Berberine's Roles in Epilepsy-Like Behavior in a Pentylenetetrazole-Induced Seizure Zebrafish Model. Front Mol Neurosci. 2018 Nov 26;11:378. doi: 10.3389/fnmol.2018.00378. eCollection 2018.

A transcriptomics analysis of the Tbx5 paralogues in zebrafish

Authors:
Boyle Anderson EAT, Ho RK
Citation:
PLoS ONE. 2018;13(12):e0208766. doi:10.1371/journal.pone.0208766
Abstract:
TBX5 is essential for limb and heart development. Mutations in TBX5 are associated with Holt-Oram syndrome in humans. Due to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Boyle Anderson EAT, Ho RK. A transcriptomics analysis of the Tbx5 paralogues in zebrafish. PLoS ONE. 2018;13(12):e0208766. doi:10.1371/journal.pone.0208766.

Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure

Authors:
Cao M, Ouyang J, Liang H, Guo J, Lin S, Yang S, Xie T, Chen S
Citation:
Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5773-5784. doi: 10.1167/iovs.18-23962
Abstract:
Purpose: The optic fissure (OF) is a transient opening in the ventral optic cup (OC) that acts as a passage for blood vessels...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cao M, Ouyang J, Liang H, Guo J, Lin S, Yang S, Xie T, Chen S. Regional Gene Expression Profile Comparison Reveals the Unique Transcriptome of the Optic Fissure. Invest Ophthalmol Vis Sci. 2018 Dec 3;59(15):5773-5784. doi: 10.1167/iovs.18-23962.

Inhibition of dengue virus replication in monocyte-derived dendritic cells by vivo-morpholino oligomers

Authors:
Phumesin P, Junking M, Panya A, Yongpitakwattana P, Noisakran S, Limjindaporn T, Yenchitsomanus PT
Citation:
Virus Res. 2018 Nov 29. pii: S0168-1702(18)30380-0. doi: 10.1016/j.virusres.2018.11.014. [Epub ahead of print]
Abstract:
Skin dendritic cells (DCs) are primary target cells of dengue virus (DENV) infection and they play an important role in its...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: human monocyte-derived dendritic cells (MDDC)
Citation Extract:
Phumesin P, Junking M, Panya A, Yongpitakwattana P, Noisakran S, Limjindaporn T, Yenchitsomanus PT. Inhibition of dengue virus replication in monocyte-derived dendritic cells by vivo-morpholino oligomers. Virus Res. 2018 Nov 29. pii: S0168-1702(18)30380-0. doi: 10.1016/j.virusres.2018.11.014. [Epub ahead of print].

Physiological effects of KDM5C on neural crest migration and eye formation during vertebrate development

Authors:
Kim Y, Jeong Y, Kwon K, Ismail T, Lee H-K, Kim C, Park J-W, Kwon O-S, Kang B-S, Lee D-S, Park TJ, Kwon T, Lee H-S
Citation:
Epigenet & Chromatin. 2018;11:72 doi:10.1186/s13072-018-0241-x
Abstract:
Background: Lysine-specific histone demethylase 5C (KDM5C) belongs to the jumonji family of demethylases and is specific for...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim Y, Jeong Y, Kwon K, Ismail T, Lee H-K, Kim C, Park J-W, Kwon O-S, Kang B-S, Lee D-S, Park TJ, Kwon T, Lee H-S. Physiological effects of KDM5C on neural crest migration and eye formation during vertebrate development. Epigenet & Chromatin. 2018;11:72 doi:10.1186/s13072-018-0241-x.

Fer1l6 Is Essential for the Development of Vertebrate Muscle Tissue in Zebrafish

Authors:
Bonventre JA, Holman C, Manchanda A, Codding SJ, Chau T, Huegel J, Barton C, Tanguay R, Johnson CP
Citation:
Mol Biol Cell. 2018 Dec 5:mbcE18060401. doi: 10.1091/mbc.E18-06-0401. [Epub ahead of print]
Abstract:
The precise spatial and temporal expression of genes is essential for proper organismal development. Despite their importance...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bonventre JA, Holman C, Manchanda A, Codding SJ, Chau T, Huegel J, Barton C, Tanguay R, Johnson CP. Fer1l6 Is Essential for the Development of Vertebrate Muscle Tissue in Zebrafish. Mol Biol Cell. 2018 Dec 5:mbcE18060401. doi: 10.1091/mbc.E18-06-0401. [Epub ahead of print].

Somatic uniparental disomy with a rare EFL1 variant causes Shwachman-Diamond syndrome through dysregulating ribosomal protein synthesis

Authors:
Lee S, Shin CH, Hong CR, Kim J-D, Kim A-R, Lee J, Kokhan O, Yoo T, Sohn YB, Kim O-K, Ko JM, Cho T-J, Wright NT, Jin S-W, Kang HJ, Kim HH, Choi M
Citation:
bioRxiv. 2018;[Preprint] doi:10.1101/483362
Abstract:
We present three unrelated Korean Shwachman-Diamond syndrome (SDS) patients that carry an incomplete but identical homozygous...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lee S, Shin CH, Hong CR, Kim J-D, Kim A-R, Lee J, Kokhan O, Yoo T, Sohn YB, Kim O-K, Ko JM, Cho T-J, Wright NT, Jin S-W, Kang HJ, Kim HH, Choi M. Somatic uniparental disomy with a rare EFL1 variant causes Shwachman-Diamond syndrome through dysregulating ribosomal protein synthesis. bioRxiv. 2018;[Preprint] doi:10.1101/483362 .

Dysregulation of NRAP degradation by KLHL41 contributes to pathophysiology in Nemaline Myopathy

Authors:
Jirka C, Pak JH, Grosgogeat CA, Marchetii MM, Gupta VA
Citation:
bioRxiv. 2018:[Preprint] doi:10.1101/487454
Abstract:
Nemaline myopathy (NM) is the most common form of congenital myopathy that results in hypotonia and muscle weakness. This...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jirka C, Pak JH, Grosgogeat CA, Marchetii MM, Gupta VA. Dysregulation of NRAP degradation by KLHL41 contributes to pathophysiology in Nemaline Myopathy. bioRxiv. 2018:[Preprint] doi:10.1101/487454.

Precursor miRNAs are trafficked along axons associated with vesicles and locally processed to regulate growth cone steering

Authors:
Corradi E, Gavoci A, Strohbuecker S, Roccuzzo M, Costa ID, Iyer A, Bridi S, Rodriguez GS, Abreu-Goodger C, Baudet M-L
Citation:
bioRxive. 2018;[Preprint] doi:10.1101/470393
Abstract:
Various species of non-coding RNAs (ncRNAs) are enriched in subcellular compartments but the mechanisms orchestrating their...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Corradi E, Gavoci A, Strohbuecker S, Roccuzzo M, Costa ID, Iyer A, Bridi S, Rodriguez GS, Abreu-Goodger C, Baudet M-L. Precursor miRNAs are trafficked along axons associated with vesicles and locally processed to regulate growth cone steering. bioRxive. 2018;[Preprint] doi:10.1101/470393.

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