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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 8347 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA

Authors:
Verbeeren J, Verma B, Niemelä EH, Yap K, Makeyev EV, Frilander MJ
Citation:
PLoS Genet. 2017;13(5):e1006824. doi:10.1371/journal.pgen.1006824
Abstract:
Cellular homeostasis of the minor spliceosome is regulated by a negative feed-back loop that targets U11-48K and U11/U12-65K...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HEK293
Citation Extract:
Verbeeren J, Verma B, Niemelä EH, Yap K, Makeyev EV, Frilander MJ. Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA. PLoS Genet. 2017;13(5):e1006824. doi:10.1371/journal.pgen.1006824.

Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues

Authors:
Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A
Citation:
Cell Rep. 2017;19:1572-85. doi:10.1016/j.celrep.2017.04.078
Abstract:
Motile cells navigate through complex tissue environments that include both attractive and repulsive cues. In response to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A. Chemokine Signaling and the Regulation of Bidirectional Leukocyte Migration in Interstitial Tissues. Cell Rep. 2017;19:1572-85. doi:10.1016/j.celrep.2017.04.078.

MiR-145 mediates zebrafish hepatic outgrowth through progranulin A signaling

Authors:
Li Y-W, Chiang K-Y, Li Y-H, Wu S-Y, Liu W, Lin C-R, Wu J-L
Citation:
PLoS ONE. 2017;12(5):e0177887. doi:0.1371/journal.pone.0177887
Abstract:
MicroRNAs (miRs) are mRNA-regulatory molecules that fine-tune gene expression and modulate both processes of development and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li Y-W, Chiang K-Y, Li Y-H, Wu S-Y, Liu W, Lin C-R, Wu J-L. MiR-145 mediates zebrafish hepatic outgrowth through progranulin A signaling. PLoS ONE. 2017;12(5):e0177887. doi:0.1371/journal.pone.0177887.

Repression of phosphatidylinositol transfer protein α ameliorates the pathology of Duchenne muscular dystrophy

Authors:
Vieira NM, Spinazzola JM, Alexander MS, Moreira YB, Kawahara G, Gibbs DE, Mead LC, Verjovski-Almeida S, Zatz M, Kunkel LM
Citation:
PNAS USA. 2017;[Epub ahead of print] doi: 10.1073/pnas.1703556114
Abstract:
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease caused by X-linked inherited mutations in the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vieira NM, Spinazzola JM, Alexander MS, Moreira YB, Kawahara G, Gibbs DE, Mead LC, Verjovski-Almeida S, Zatz M, Kunkel LM. Repression of phosphatidylinositol transfer protein α ameliorates the pathology of Duchenne muscular dystrophy. PNAS USA. 2017;[Epub ahead of print] doi: 10.1073/pnas.1703556114.

Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease

Authors:
Chen GL, Ma Q, Goswami D, Shang J, Miller GM
Citation:
J Cell Mol Med. 2017 May 19. doi: 10.1111/jcmm.13209. [Epub ahead of print]
Abstract:
Huntington's disease (HD) is caused by a genetically mutated huntingtin (mHtt) protein with expanded polyQ stretch, which...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: STHdhQ7/7 and STHdhQ111/111 from transgenic humanized mice
Citation Extract:
Chen GL, Ma Q, Goswami D, Shang J, Miller GM. Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease. J Cell Mol Med. 2017 May 19. doi: 10.1111/jcmm.13209. [Epub ahead of print].

Activating transcription factor 3 promotes spinal cord regeneration of adult zebrafish

Authors:
Wang LF, Huang SB, Zhao HD, Liu CJ, Yao L, Shen YQ
Citation:
Biochem Biophys Res Commun. 2017 May 15. pii: S0006-291X(17)30953-1. doi: 10.1016/j.bbrc.2017.05.079. [Epub ahead of print]
Abstract:
Zebrafish is an excellent model to study the mechanisms underlying successful central nervous system (CNS) regeneration....
Organism or Cell Type:
zebrafish
Citation Extract:
Wang LF, Huang SB, Zhao HD, Liu CJ, Yao L, Shen YQ. Activating transcription factor 3 promotes spinal cord regeneration of adult zebrafish. Biochem Biophys Res Commun. 2017 May 15. pii: S0006-291X(17)30953-1. doi: 10.1016/j.bbrc.2017.05.079. [Epub ahead of print].

Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish

Authors:
Gerri C, Marín-Juez R, Marass M, Marks A, Maischein H-M, Stainier DYR
Citation:
Nat Comm. 2017;8:15492. doi:10.1038/ncomms15492
Abstract:
Macrophages are known to interact with endothelial cells during developmental and pathological angiogenesis but the molecular...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gerri C, Marín-Juez R, Marass M, Marks A, Maischein H-M, Stainier DYR. Hif-1α regulates macrophage-endothelial interactions during blood vessel development in zebrafish. Nat Comm. 2017;8:15492. doi:10.1038/ncomms15492.

Characterization of TRPA channels in the starfish Patiria pectinifera: involvement of thermally activated TRPA1 in thermotaxis in marine planktonic larvae

Authors:
Saito S, Hamanaka G, Kawai N, Furukawa R, Gojobori J, Tominaga M, Kaneko H, Satta Y
Citation:
Sci Rep. 2017;7:2173. doi:10.1038/s41598-017-02171-8
Abstract:
The vast majority of marine invertebrates spend their larval period as pelagic plankton and are exposed to various...
Delivery Method:
microinjection
Organism or Cell Type:
Patiria pectinifera (sea star)
Citation Extract:
Saito S, Hamanaka G, Kawai N, Furukawa R, Gojobori J, Tominaga M, Kaneko H, Satta Y. Characterization of TRPA channels in the starfish Patiria pectinifera: involvement of thermally activated TRPA1 in thermotaxis in marine planktonic larvae. Sci Rep. 2017;7:2173. doi:10.1038/s41598-017-02171-8.

Quantitative determination of AVI-7100 (Radavirsen), a phosphorodiamidate morpholino oligomer (PMOplus®), in human plasma using LC-MS/MS

Authors:
Meng M, Zhang J, Liu A, Reuschel S, Sazani P, Wong M
Citation:
Bioanalysis. 2017 May 18. doi: 10.4155/bio-2016-0289. [Epub ahead of print]
Abstract:
AIM: AVI-7100 (Radavirsen) is a 20-mer phosphorodiamidate morpholino oligomer (PMOplus®) for the treatment of influenza....
Organism or Cell Type:
human
Citation Extract:
Meng M, Zhang J, Liu A, Reuschel S, Sazani P, Wong M. Quantitative determination of AVI-7100 (Radavirsen), a phosphorodiamidate morpholino oligomer (PMOplus®), in human plasma using LC-MS/MS. Bioanalysis. 2017 May 18. doi: 10.4155/bio-2016-0289. [Epub ahead of print].

TGFβ mediated structural remodeling facilitates optic fissure fusion and the necessity of BMP antagonism in this process

Authors:
Knickmeyer MD, Mateo JL, Eckert P, Roussa E, Rahhal B, Zuniga A, Krieglstein K, Wittbrodt J, Heermann S
Citation:
bioRxiv. 2017;doi:10.1101/131599
Abstract:
The optic fissure is a transient gap in the developing vertebrate eye, which must be closed as development proceeds. A...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Knickmeyer MD, Mateo JL, Eckert P, Roussa E, Rahhal B, Zuniga A, Krieglstein K, Wittbrodt J, Heermann S. TGFβ mediated structural remodeling facilitates optic fissure fusion and the necessity of BMP antagonism in this process. bioRxiv. 2017;doi:10.1101/131599 .

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