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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 8236 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme

Authors:
Torraca V, Tulotta C, Snaar-Jagalska BE, Meijer AH
Citation:
Sci Rep. 2017 Mar 23;7:45061. doi: 10.1038/srep45061
Abstract:
CXC chemokine receptor 4 plays a critical role in chemotaxis and leukocyte differentiation. Furthermore, there is increasing...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Torraca V, Tulotta C, Snaar-Jagalska BE, Meijer AH. The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme. Sci Rep. 2017 Mar 23;7:45061. doi: 10.1038/srep45061.

Chordin and dickkopf-1b are essential for the formation of head structures through activation of the FGF signaling pathway in zebrafish

Authors:
Tanaka S, Hosokawa H, Weinberg ES, Maegawa S
Citation:
Dev Biol. 2017 Mar 1. pii: S0012-1606(16)30469-9. doi: 10.1016/j.ydbio.2017.02.018. [Epub ahead of print]
Abstract:
The ability of the Spemann organizer to induce dorsal axis formation is dependent on downstream factors of the maternal Wnt/β-...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tanaka S, Hosokawa H, Weinberg ES, Maegawa S. Chordin and dickkopf-1b are essential for the formation of head structures through activation of the FGF signaling pathway in zebrafish. Dev Biol. 2017 Mar 1. pii: S0012-1606(16)30469-9. doi: 10.1016/j.ydbio.2017.02.018. [Epub ahead of print].

Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders

Authors:
Bezzerides VJ, Zhang A, Xiao L, Simonson B, Khedkar SA, Baba S, Ottaviano F, Lynch S, Hessler K, Rigby AC, Milan D, Das S, Rosenzweig A
Citation:
Sci Rep. 2017;7:346. doi:10.1038/s41598-017-00413-3
Abstract:
Alterations in sodium flux (INa) play an important role in the pathogenesis of cardiac arrhythmias and may also contribute to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bezzerides VJ, Zhang A, Xiao L, Simonson B, Khedkar SA, Baba S, Ottaviano F, Lynch S, Hessler K, Rigby AC, Milan D, Das S, Rosenzweig A. Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders. Sci Rep. 2017;7:346. doi:10.1038/s41598-017-00413-3.

Systemic Antisense Therapeutics for Dystrophin and Myostatin Exon Splice Modulation Improve Muscle Pathology of Adult mdx Mice

Authors:
Lu-Nguyen N, Malerba A, Popplewell L, Schnell F, Hanson G, Dickson G
Citation:
Mol Ther Nucleic Acids. 2017 Mar 17;6:15-28. doi: 10.1016/j.omtn.2016.11.009
Abstract:
Antisense-mediated exon skipping is a promising approach for the treatment of Duchenne muscular dystrophy (DMD), a rare life-...
Delivery Method:
peptide-linked
Organism or Cell Type:
mouse mdx
Citation Extract:
Lu-Nguyen N, Malerba A, Popplewell L, Schnell F, Hanson G, Dickson G. Systemic Antisense Therapeutics for Dystrophin and Myostatin Exon Splice Modulation Improve Muscle Pathology of Adult mdx Mice. Mol Ther Nucleic Acids. 2017 Mar 17;6:15-28. doi: 10.1016/j.omtn.2016.11.009.

Molecular physiology of the hypocalcemic action of fibroblast growth factor 23 in zebrafish (Danio rerio)

Authors:
Lin CH, Hu HJ, Hwang PP
Citation:
Endocrinology. 2017 Mar 1. doi: 10.1210/en.2016-1883. [Epub ahead of print]
Abstract:
Fibroblast growth factor 23 (FGF23), a hormone required for phosphorus metabolism, was recently proposed to act on Ca2+ uptake...
Organism or Cell Type:
zebrafish
Citation Extract:
Lin CH, Hu HJ, Hwang PP. Molecular physiology of the hypocalcemic action of fibroblast growth factor 23 in zebrafish (Danio rerio). Endocrinology. 2017 Mar 1. doi: 10.1210/en.2016-1883. [Epub ahead of print].

sall1 and sall4 repress pou5f3 family expression to allow neural patterning, differentiation, and morphogenesis in Xenopus laevis

Authors:
Exner CR, Kim AY, Mardjuki SM, Harland RM
Citation:
Dev Biol. 2017 Mar 18. pii: S0012-1606(16)30754-0. doi: 10.1016/j.ydbio.2017.03.015. [Epub ahead of print]
Abstract:
The embryonic precursor of the vertebrate central nervous system, the neural plate, is patterned along the anterior-posterior...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Exner CR, Kim AY, Mardjuki SM, Harland RM. sall1 and sall4 repress pou5f3 family expression to allow neural patterning, differentiation, and morphogenesis in Xenopus laevis. Dev Biol. 2017 Mar 18. pii: S0012-1606(16)30754-0. doi: 10.1016/j.ydbio.2017.03.015. [Epub ahead of print].

Discovery of Novel Determinants of Endothelial Lineage using Chimeric Heterokaryons

Authors:
Wong WT, Matrone G, Tian XY, Tomoiaga SA, Au KF, Meng S, Yamazoe S, Sieveking D, Chen K, Burns DM, Chen JK, Blau HM, Cooke JP
Citation:
eLife. 2017; doi:10.7554/eLife.23588
Abstract:
We wish to identify determinants of endothelial lineage. Murine embryonic stem cells (mESC) were fused with human endothelial...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wong WT, Matrone G, Tian XY, Tomoiaga SA, Au KF, Meng S, Yamazoe S, Sieveking D, Chen K, Burns DM, Chen JK, Blau HM, Cooke JP. Discovery of Novel Determinants of Endothelial Lineage using Chimeric Heterokaryons. eLife. 2017; doi:10.7554/eLife.23588.

Actomyosin-generated tension on cadherin is similar between dividing and non-dividing epithelial cells in early Xenopus laevis embryos

Authors:
Herbomel G, Hatte G, Roul J, Padilla-Parra S, Tassan J-P, Tramier M
Citation:
Sci Rep. 2017;7:45058 doi:10.1038/srep45058
Abstract:
Epithelia represent a unique situation where polarized cells must maintain sufficiently strong cell-cell contacts to guarantee...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Herbomel G, Hatte G, Roul J, Padilla-Parra S, Tassan J-P, Tramier M. Actomyosin-generated tension on cadherin is similar between dividing and non-dividing epithelial cells in early Xenopus laevis embryos. Sci Rep. 2017;7:45058 doi:10.1038/srep45058.

Paxillin Genes and Actomyosin Contractility Regulate Myotome Morphogenesis in Zebrafish

Authors:
Jacob AE, Amack JD, Turner CE
Citation:
Dev Biol. 2017 Mar 14. pii: S0012-1606(16)30694-7. doi: 10.1016/j.ydbio.2017.03.012. [Epub ahead of print]
Abstract:
Paxillin (Pxn) is a key adapter protein and signaling regulator at sites of cell-extracellular matrix (ECM) adhesion. Here, we...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jacob AE, Amack JD, Turner CE. Paxillin Genes and Actomyosin Contractility Regulate Myotome Morphogenesis in Zebrafish. Dev Biol. 2017 Mar 14. pii: S0012-1606(16)30694-7. doi: 10.1016/j.ydbio.2017.03.012. [Epub ahead of print].

Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine

Authors:
Xu J, Lu Z, Narayan A, Le Rouzic VP, Xu M, Hunkele A, Brown TG, Hoefer WF, Rossi GC, Rice RC, Martínez-Rivera A, Rajadhyaksha AM, Cartegni L, Bassoni DL, Pasternak GW, Pan Y-X
Citation:
J Clin Invest. 2017;[Epub ahead of print] doi:10.1172/JCI88760
Abstract:
Extensive 3′ alternative splicing of the mu opioid receptor gene OPRM1 creates multiple C-terminal splice variants. However,...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mouse
Citation Extract:
Xu J, Lu Z, Narayan A, Le Rouzic VP, Xu M, Hunkele A, Brown TG, Hoefer WF, Rossi GC, Rice RC, Martínez-Rivera A, Rajadhyaksha AM, Cartegni L, Bassoni DL, Pasternak GW, Pan Y-X. Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine. J Clin Invest. 2017;[Epub ahead of print] doi:10.1172/JCI88760.

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