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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 8886 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

Authors:
Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP
Citation:
Nat Comm. 2018;2292(9):[Epub] doi:10.1038/s41467-018-04602-0
Abstract:
Oxidized phospholipids (oxPAPC) induce endothelial dysfunction and atherosclerosis. Here we show that oxPAPC induce a gene...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hitzel J, Lee E, Zhang Y, Bibli SI, Li X, Zukunft S, Pflüger B, Hu J, Schürmann C, Vasconez AE, Oo JA, Kratzer A, Kumar S, Rezende F, Josipovic I, Thomas D, Giral H, Schreiber Y, Geisslinger G, Fork C, Yang X, Sigala F, Romanoski CE, Kroll J, Jo H, Landmesser U, Lusis AJ, Namgaladze D, Fleming I, Leisegang MS, Zhu J, Brandes RP. Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells. Nat Comm. 2018;2292(9):[Epub] doi:10.1038/s41467-018-04602-0.

ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells

Authors:
Hofsteen P, Robitaille AM, Strash N, Palpant N, Moon RT, Pabon L, Murry CE
Citation:
iScience. 2018 Apr 27;2:88-100. doi: 10.1016/j.isci.2018.03.010
Abstract:
Cardiac development requires coordinated biphasic regulation of the WNT/β-catenin signaling pathway. By intersecting gene...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hofsteen P, Robitaille AM, Strash N, Palpant N, Moon RT, Pabon L, Murry CE. ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells. iScience. 2018 Apr 27;2:88-100. doi: 10.1016/j.isci.2018.03.010.

Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins

Authors:
Chi B, O'Connell JD, Yamazaki T, Gangopadhyay J, Gygi SP, Reed R
Citation:
Sci Rep. 2018 Jun 8;8(1):8755. doi: 10.1038/s41598-018-27136-3
Abstract:
Mutations in multiple RNA/DNA binding proteins cause Amyotrophic Lateral Sclerosis (ALS). Included among these are the three...
Organism or Cell Type:
cell-free: HeLa nuclear extract
Citation Extract:
Chi B, O'Connell JD, Yamazaki T, Gangopadhyay J, Gygi SP, Reed R. Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins. Sci Rep. 2018 Jun 8;8(1):8755. doi: 10.1038/s41598-018-27136-3.

Controlling Cell Fate Specification System by Key Genes Determined from Network Structure

Authors:
Kobayashi K, Maeda K, Tokuoka M, Mochizuki A, Satou Y
Citation:
iScience. 2018;[Epub proof] doi:10.1016/j.isci.2018.05.004
Abstract:
Network structures describing regulation between biomolecules have been determined in many biological systems. Dynamics of...
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis (ascidian)
Citation Extract:
Kobayashi K, Maeda K, Tokuoka M, Mochizuki A, Satou Y. Controlling Cell Fate Specification System by Key Genes Determined from Network Structure. iScience. 2018;[Epub proof] doi:10.1016/j.isci.2018.05.004.

HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway

Authors:
Swaroop S, Mahadevan A, Shankar SK, Adlakha YK, Basu A
Citation:
J Neuroinflammation. 2018 Jun 9;15(1):177. doi: 10.1186/s12974-018-1214-5
Abstract:
BACKGROUND: Interleukin-1β (IL-1β) is one of the most important cytokine secreted by activated microglia as it orchestrates the...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
BALB/c mice
Citation Extract:
Swaroop S, Mahadevan A, Shankar SK, Adlakha YK, Basu A. HSP60 critically regulates endogenous IL-1β production in activated microglia by stimulating NLRP3 inflammasome pathway. J Neuroinflammation. 2018 Jun 9;15(1):177. doi: 10.1186/s12974-018-1214-5.

Macrophages protect Talaromyces marneffei conidia from myeloperoxidase-dependent neutrophil fungicidal activity during infection establishment in vivo

Authors:
Ellett F, Pazhakh V, Pase L, Benard EL, Weerasinghe H, Azabdaftari D, Alasmari S, Andrianopoulos A, Lieschke GJ
Citation:
PLoS Pathog. 2018 Jun 8;14(6):e1007063. doi: 10.1371/journal.ppat.1007063. [Epub ahead of print]
Abstract:
Neutrophils and macrophages provide the first line of cellular defence against pathogens once physical barriers are breached,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ellett F, Pazhakh V, Pase L, Benard EL, Weerasinghe H, Azabdaftari D, Alasmari S, Andrianopoulos A, Lieschke GJ. Macrophages protect Talaromyces marneffei conidia from myeloperoxidase-dependent neutrophil fungicidal activity during infection establishment in vivo. PLoS Pathog. 2018 Jun 8;14(6):e1007063. doi: 10.1371/journal.ppat.1007063. [Epub ahead of print].

Integrating glycomics and genomics uncovers SLC10A7 as essential factor for bone mineralization by regulating post-Golgi protein transport and glycosylation

Authors:
Ashikov A, Abu Bakar N, Wen XY, Niemeijer M, Rodrigues Pinto Osorio G, Brand-Arzamendi K, Hasadsri L, Hansikova H, Raymond K, Vicogne D, Simon MEH, Pfundt R, Timal S, Beumers R, Biot C, Smeets R, Kersten M, Huijben K; CDG group , Ta Linders P, van den Bogaart G, van Hijum SAFT, Rodenburg R, van den Heuvel LP, van Spronsen F, Honzik T, Foulquier F, van Scherpenzeel M, Lefeber DJ
Citation:
Hum Mol Genet. 2018 Jun 5. doi: 10.1093/hmg/ddy213. [Epub ahead of print]
Abstract:
Genomics methodologies have significantly improved elucidation of Mendelian disorders. The combination with high-throughput...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ashikov A, Abu Bakar N, Wen XY, Niemeijer M, Rodrigues Pinto Osorio G, Brand-Arzamendi K, Hasadsri L, Hansikova H, Raymond K, Vicogne D, Simon MEH, Pfundt R, Timal S, Beumers R, Biot C, Smeets R, Kersten M, Huijben K; CDG group , Ta Linders P, van den Bogaart G, van Hijum SAFT, Rodenburg R, van den Heuvel LP, van Spronsen F, Honzik T, Foulquier F, van Scherpenzeel M, Lefeber DJ. Integrating glycomics and genomics uncovers SLC10A7 as essential factor for bone mineralization by regulating post-Golgi protein transport and glycosylation. Hum Mol Genet. 2018 Jun 5. doi: 10.1093/hmg/ddy213. [Epub ahead of print].

BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity

Authors:
Row RH, Pegg A, Kinney B, Farr GH, Maves L, Lowell S, Wilson V, Martin BL
Citation:
eLife. 2018;7:e31018. doi:10.7554/eLife.31018
Abstract:
The mesodermal germ layer is patterned into mediolateral subtypes by signaling factors including BMP and FGF. How these...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Row RH, Pegg A, Kinney B, Farr GH, Maves L, Lowell S, Wilson V, Martin BL. BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity. eLife. 2018;7:e31018. doi:10.7554/eLife.31018.

Blocking the 5′ splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch

Authors:
Cheatham AM, Davis SE, Khatua AK, Popik W
Citation:
Sci Rep. 2018;8:8739 doi:10.1038/s41598-018-27104-x
Abstract:
APOL1 risk alleles G1 or G2 are associated with a kidney disease phenotype exclusively in people of recent African ancestry....
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: AB8/13 podocytes
Citation Extract:
Cheatham AM, Davis SE, Khatua AK, Popik W. Blocking the 5′ splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch. Sci Rep. 2018;8:8739 doi:10.1038/s41598-018-27104-x.

Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

Authors:
Gao X, Ran N, Dong X, Zuo B, Yang R, Zhuo Q, Hong M. Moulton HM, Seow Y, Yin HF
Citation:
Sci Transl Med. 2018;10(444):eaat0195. doi:10.1126/scitranslmed.aat0195
Abstract:
Exosomes are circulating nanovesicular carriers of macromolecules, increasingly used for diagnostics and therapeutics. The...
Delivery Method:
exosome
Organism or Cell Type:
mice
Citation Extract:
Gao X, Ran N, Dong X, Zuo B, Yang R, Zhuo Q, Hong M. Moulton HM, Seow Y, Yin HF. Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy. Sci Transl Med. 2018;10(444):eaat0195. doi:10.1126/scitranslmed.aat0195.

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