You are here

lunatic fringe regulates Delta-Notch induction of hypochord in zebrafish

Authors: 
Appel B, Marasco P, McClung LE, Latimer AJ
Citation: 
Dev Dyn. 2003 Oct;228(2):281-6
Abstract: 
Cells that occupy the midline of vertebrate embryos arise from a common population of precursors. Several lines of evidence indicate that Delta-Notch signaling regulates specification of midline precursors for different fates. We show that zebrafish midline precursors transiently express lunatic fringe, which encodes a glycosyltransferase that modifies Notch activity in response to its ligands, and that lunatic fringe function is required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain.
Organism or Cell Type: 
zebrafish