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lunatic fringe regulates Delta-Notch induction of hypochord in zebrafish

Appel B, Marasco P, McClung LE, Latimer AJ
Dev Dyn. 2003 Oct;228(2):281-6
Cells that occupy the midline of vertebrate embryos arise from a common population of precursors. Several lines of evidence indicate that Delta-Notch signaling regulates specification of midline precursors for different fates. We show that zebrafish midline precursors transiently express lunatic fringe, which encodes a glycosyltransferase that modifies Notch activity in response to its ligands, and that lunatic fringe function is required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain.
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