You are here
|Paper: Induction of cryptic pre-mRNA splice-switching by antisense oligonucleotide||
Mostly phosphorothioate work
Ham KA, Keegan NP, McIntosh CS, Aung-Htut MT, Zaw K, Greer K, Fletcher Sue, Wilton SD. Induction of cryptic pre-mRNA splice-switching by antisense oligonucleotides. Sci Rep. 2021;11(1):15137 doi:10.1038/s41598-021-94639-x
|Friday, July 23, 2021 - 14:22|
|Genetic compensation in soybean (no Morpholino)||
Genetic compensation in soybean: I am putting this in the blog as an example of an organism distant from zebrafish which is also compensating for mutation.
|Friday, July 16, 2021 - 14:42|
|Nice introduction to splice-modification therapy from OTS||
From the Oligonucleotide Therapeutics Society: "Can Oligonucleotides Target RNA Splicing to Treat Disease?"
|Wednesday, June 23, 2021 - 09:41|
|Mutant-morphant mismatch but no genetic compensation||
Zebrafish Chromosome 14 Gene Differential Expression in the fmr1 h u2787 Model of Fragile X Syndrome.
|Friday, June 18, 2021 - 08:14|
|Morphant vs mutant: "...this knockout line is deemed unsuitable for our study."||
Here’s a nice description of why, in this study, morphants are preferable to mutants.
|Friday, June 11, 2021 - 11:53|
|Review of neurodegenerative disease and splice modulation||
Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies.
|Monday, May 24, 2021 - 13:32|
|Therapeutic Modulation of RNA Splicing in Malignant and Non-Malignant Disease (Review)||
Therapeutic Modulation of RNA Splicing in Malignant and Non-Malignant Disease.
|Monday, May 17, 2021 - 11:33|
|SARS-CoV-2 RNA targets for steric blocking||
Potantial targets for steric blocking on the SARS-CoV-2 genome and transcripts.
The SARS-CoV-2 RNA interactome.
|Monday, May 17, 2021 - 10:23|
|Positive control, human and mouse splice modification||
Flynn LL, Mitrpant C, Adams A, Pitout IL, Stirnweiss A, Fletcher S, Wilton SD. Targeted SMN Exon Skipping: A Useful Control to Assess In Vitro and In Vivo Splice-Switching Studies. Biomedicines. 2021;9(5):552. doi:10.3390/biomedicines9050552
|Friday, May 14, 2021 - 11:52|
|MO knockdown of ectopic GFP in axlotl||
There are few papers reporting using a Morpholino to directly target GFP in vivo; here is one example.
|Friday, April 23, 2021 - 11:21|