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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12221 scientific papers returned from the database with the search filters currently being used below.

F86. Molecular mechanism of the TNIK gene affecting the action of antipsychotic drugs through the glutamate pathway

Authors:
Xu Q, Qin S, He L, Yu S
Citation:
European Neuropsychopharmacology, Volume 87, Supplement 1, 2024, Pages 251-252, ISSN 0924-977X, https://doi.org/10.1016/j.euroneuro.2024.08.497
Epub:
Not Epub
Abstract:
Background Schizophrenia (SCZ) is a complex psychiatric disorder primarily treated with antipsychotic drugs (APDs), yet the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xu Q, Qin S, He L, Yu S. F86. Molecular mechanism of the TNIK gene affecting the action of antipsychotic drugs through the glutamate pathway. European Neuropsychopharmacology, Volume 87, Supplement 1, 2024, Pages 251-252, ISSN 0924-977X, https://doi.org/10.1016/j.euroneuro.2024.08.497.

Multi-omics integration analysis identifies pathogenic candidate genes of congenital heart defects with vascular malformation

Authors:
Ding XW, Huang JX, Chen YH, Li ZY, Wu YZ, Qian ZL, Feng WQ, Li YR, Zhao LD, Zhao PJ, Lu YN, Yu Y
Citation:
European Heart Journal, Volume 45, Issue Supplement_1, October 2024, ehae666.2109, https://doi.org/10.1093/eurheartj/ehae666.2109
Epub:
Not Epub
Abstract:
Background Congenital heart defects (CHD) with vascular malformation harbors numerous genetic and epigenetic aberrations of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ding XW, Huang JX, Chen YH, Li ZY, Wu YZ, Qian ZL, Feng WQ, Li YR, Zhao LD, Zhao PJ, Lu YN, Yu Y. Multi-omics integration analysis identifies pathogenic candidate genes of congenital heart defects with vascular malformation. European Heart Journal, Volume 45, Issue Supplement_1, October 2024, ehae666.2109, https://doi.org/10.1093/eurheartj/ehae666.2109.

Actin Depolymerizing Factor Destrin Regulates Cilia Development and Function during Vertebrate Embryogenesis

Authors:
Kim Y, Lee HK, Park KY, Ismail T, Lee H, Lee HS
Citation:
Dev Reprod. 2024 Sep;28(3):109-119. doi: 10.12717/DR.2024.28.3.109. Epub 2024 Sep 30. PMID: 39444639; PMCID: PMC11495882
Epub:
Not Epub
Abstract:
The actin cytoskeleton plays fundamental roles in ciliogenesis and the actin depolymerizing factor destrin regulates actin...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim Y, Lee HK, Park KY, Ismail T, Lee H, Lee HS. Actin Depolymerizing Factor Destrin Regulates Cilia Development and Function during Vertebrate Embryogenesis. Dev Reprod. 2024 Sep;28(3):109-119. doi: 10.12717/DR.2024.28.3.109. Epub 2024 Sep 30. PMID: 39444639; PMCID: PMC11495882.

Light-modulated neural control of sphincter regulation in the evolution of through-gut

Authors:
Yaguchi J, Sakai K, Horiuchi A, Yamamoto T, Yamashita T, Yaguchi S
Citation:
Nat Commun. 2024 Oct 18;15(1):8881. doi: 10.1038/s41467-024-53203-7. PMID: 39424783; PMCID: PMC11489725
Epub:
Not Epub
Abstract:
The development of a continuous digestive tract, or through-gut, represents a key milestone in bilaterian evolution. However,...
Delivery Method:
microinjection
Organism or Cell Type:
Hemicentrotus pulcherrimus (sea urchin)
Citation Extract:
Yaguchi J, Sakai K, Horiuchi A, Yamamoto T, Yamashita T, Yaguchi S. Light-modulated neural control of sphincter regulation in the evolution of through-gut. Nat Commun. 2024 Oct 18;15(1):8881. doi: 10.1038/s41467-024-53203-7. PMID: 39424783; PMCID: PMC11489725.

Hypusinated and unhypusinated isoforms of eIF5A exert distinct effects in models of pancreas development and function

Authors:
Anderson CM, Kulkarni A, Maier B, Huang F, Figatner K, Chakraborty A, Pratuangtham S, May SC, Tersey SA, Anderson RM, Mirmira RG
Citation:
bioRxiv [preprint] 2024.10.27.620489; doi: https://doi.org/10.1101/2024.10.27.620489
Epub:
Not Epub
Abstract:
Hypusination of eukaryotic translation initiation factor 5A (eIF5A) is essential for its role in translation elongation and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Anderson CM, Kulkarni A, Maier B, Huang F, Figatner K, Chakraborty A, Pratuangtham S, May SC, Tersey SA, Anderson RM, Mirmira RG. Hypusinated and unhypusinated isoforms of eIF5A exert distinct effects in models of pancreas development and function. bioRxiv [preprint] 2024.10.27.620489; doi: https://doi.org/10.1101/2024.10.27.620489.

Emx2 is an essential regulator of ciliated cell development across embryonic tissues

Authors:
Nguyen TK, Rodriguez J-M, Wesselman HM, Wingert RA
Citation:
ISCIENCE (2024), doi.org/10.1016/j.isci.2024.111271
Epub:
Not Epub
Abstract:
Cilia are hair-like organelles with vital physiological roles, and ciliogenesis defects underlie a range of severe congenital...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nguyen TK, Rodriguez J-M, Wesselman HM, Wingert RA. Emx2 is an essential regulator of ciliated cell development across embryonic tissues. ISCIENCE (2024), doi.org/10.1016/j.isci.2024.111271.

Differential Sensitivity of Midline Patterning to Mitosis during and after Primitive Streak Extension

Authors:
Zhao Z, Asai R, Mikawa T
Citation:
bioRxiv [preprint] 2024.10.25.620280; doi: https://doi.org/10.1101/2024.10.25.620280
Epub:
Not Epub
Abstract:
Background: Midline establishment is a fundamental process during early embryogenesis for Bilaterians. Midline patterning in...
Delivery Method:
electroporation
Organism or Cell Type:
chick embryo
Citation Extract:
Zhao Z, Asai R, Mikawa T. Differential Sensitivity of Midline Patterning to Mitosis during and after Primitive Streak Extension. bioRxiv [preprint] 2024.10.25.620280; doi: https://doi.org/10.1101/2024.10.25.620280.

An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis

Authors:
Niu K, Zhang C, Liu C, Wu W, Yan Y, Zheng A, Liu S, Shi Z, Yang M, Wang W, Xiao Q
Citation:
Eur J Cell Biol. 2024 Oct 24;103(4):151465. doi: 10.1016/j.ejcb.2024.151465. Online ahead of print. PMID: 39471724
Epub:
Not Epub
Abstract:
Mesoderm induction is a crucial step for vascular cell specification, vascular development and vasculogenesis. However, the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Niu K, Zhang C, Liu C, Wu W, Yan Y, Zheng A, Liu S, Shi Z, Yang M, Wang W, Xiao Q. An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis. Eur J Cell Biol. 2024 Oct 24;103(4):151465. doi: 10.1016/j.ejcb.2024.151465. Online ahead of print. PMID: 39471724.

PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation

Authors:
Song K, Chen D, Li J, Zhang J, Tian Y, Xu X, Wang B, Huang Z, Lou S, Kang J, Zhang N, Yang X, Ma W
Citation:
Adv Biol (Weinh). 2024 Oct 22:e2400307. doi: 10.1002/adbi.202400307. Online ahead of print. PMID: 39435597
Epub:
Not Epub
Abstract:
Oocyte meiotic errors can cause infertility, miscarriage, and birth defects. Here the role and the underlying mechanism of p21...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocysts
Citation Extract:
Song K, Chen D, Li J, Zhang J, Tian Y, Xu X, Wang B, Huang Z, Lou S, Kang J, Zhang N, Yang X, Ma W. PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation. Adv Biol (Weinh). 2024 Oct 22:e2400307. doi: 10.1002/adbi.202400307. Online ahead of print. PMID: 39435597.

MMP21 behaves as a fluid flow transported morphogen to impart laterality during development

Authors:
Ott T, Brugger A, Szenker-Ravi E, Kurrle Y, Aberle O, Tisler M, Blum M, Whalen S, Bouvagnet P, Reversade B, Schweickert A
Citation:
bioRxiv [Preprint] 2024.10.13.618030; doi: https://doi.org/10.1101/2024.10.13.618030
Epub:
Not Epub
Abstract:
Heterotaxy (HTX) is frequently caused by deleterious variants in the gene encoding Matrix metallopeptidase 21 (MMP21). However...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Ott T, Brugger A, Szenker-Ravi E, Kurrle Y, Aberle O, Tisler M, Blum M, Whalen S, Bouvagnet P, Reversade B, Schweickert A. MMP21 behaves as a fluid flow transported morphogen to impart laterality during development. bioRxiv [Preprint] 2024.10.13.618030; doi: https://doi.org/10.1101/2024.10.13.618030.

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