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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12511 scientific papers returned from the database with the search filters currently being used below.

A steady-state pool of calcium-dependent actin is maintained by Homer and controls epithelial mechanosensation

Authors:
Matsuzawa K, Suzuki M, Cho Y, Fujinaga R, Ikenouchi J
Citation:
Proc Natl Acad Sci U S A. 2025 Oct 28;122(43):e2509784122. doi: 10.1073/pnas.2509784122. Epub 2025 Oct 24. PMID: 41134626
Epub:
Not Epub
Abstract:
Epithelial cells are inherently contractile and in homeostasis, tissue integrity is maintained by balancing the uneven...
Link:
https://www.pnas.org/doi/10.1073/pnas.2509784122
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Matsuzawa K, Suzuki M, Cho Y, Fujinaga R, Ikenouchi J. A steady-state pool of calcium-dependent actin is maintained by Homer and controls epithelial mechanosensation. Proc Natl Acad Sci U S A. 2025 Oct 28;122(43):e2509784122. doi: 10.1073/pnas.2509784122. Epub 2025 Oct 24. PMID: 41134626.

Targeted α-Synuclein mRNA Degradation by PMO-Based RNA-Degrading Chimeras

Authors:
Wang N, Hegde S, Tang Z, Liu H, Feng G, Niu L, Li H, Gadhave K, Kumbhar R, Zhang S, Dawson TM, Pantelyat A, Rosenthal LS, Ying M, Mao X, Wang J
Citation:
bioRxiv [Preprint] 2025.10.17.683180; doi: https://doi.org/10.1101/2025.10.17.683180
Epub:
Not Epub
Abstract:
α-Synucleinopathies are devastating neurodegenerative diseases characterized by pathological accumulation of a neuronal protein...
Link:
https://www.biorxiv.org/content/10.1101/2025.10.17.683180v1.full
Delivery Method:
cells: Endo-Porter PEG; mice: stereotaxic injection
Organism or Cell Type:
HEK293T cells, primary cortical neurons from humanized SNCA PAC-Tg (SNCAWT) mice, human iPSC neurons; humanized SNCA mice
Citation Extract:
Wang N, Hegde S, Tang Z, Liu H, Feng G, Niu L, Li H, Gadhave K, Kumbhar R, Zhang S, Dawson TM, Pantelyat A, Rosenthal LS, Ying M, Mao X, Wang J. Targeted α-Synuclein mRNA Degradation by PMO-Based RNA-Degrading Chimeras. bioRxiv [Preprint] 2025.10.17.683180; doi: https://doi.org/10.1101/2025.10.17.683180.

Telomerase and alternative lengthening of telomeres coexist in the regenerating zebrafish caudal fins

Authors:
Martínez-Balsalobre E, Anchelin M, Hernández-Silva D, Mione MC, Mulero V, Alcaraz-Pérez F, García-Castillo J, Cayuela ML
Citation:
EMBO Rep. 2025 Oct 21. doi: 10.1038/s44319-025-00602-6. Epub ahead of print. PMID: 41120592
Epub:
Not Epub
Abstract:
Telomeres are essential for chromosome protection and genomic stability, and telomerase function is critical for organ...
Link:
https://www.embopress.org/doi/full/10.1038/s44319-025-00602-6
Delivery Method:
Vivo-Morpholino injection post-caudal fin amputation
Organism or Cell Type:
zebrafish
Citation Extract:
Martínez-Balsalobre E, Anchelin M, Hernández-Silva D, Mione MC, Mulero V, Alcaraz-Pérez F, García-Castillo J, Cayuela ML. Telomerase and alternative lengthening of telomeres coexist in the regenerating zebrafish caudal fins. EMBO Rep. 2025 Oct 21. doi: 10.1038/s44319-025-00602-6. Epub ahead of print. PMID: 41120592.

Maternal factor OTX2 regulates human embryonic genome activation and early development

Authors:
Wang Q, Zhang C, Dang Y, Sun J, Zou Z, Li C, Ma S, Li Z, Liu H, Ma X, Yang Z, Wang L, Wu K, Chen ZJ, Xie W, Zhao H
Citation:
Nat Genet. 2025 Oct 27. doi: 10.1038/s41588-025-02350-8. Epub ahead of print. PMID: 41145868
Epub:
Not Epub
Abstract:
Transcription factors (TFs) are instrumental in kickstarting embryonic genome activation (EGA) in many species, yet their...
Link:
https://www.nature.com/articles/s41588-025-02350-8
Delivery Method:
injection
Organism or Cell Type:
human embryo
Citation Extract:
Wang Q, Zhang C, Dang Y, Sun J, Zou Z, Li C, Ma S, Li Z, Liu H, Ma X, Yang Z, Wang L, Wu K, Chen ZJ, Xie W, Zhao H. Maternal factor OTX2 regulates human embryonic genome activation and early development. Nat Genet. 2025 Oct 27. doi: 10.1038/s41588-025-02350-8. Epub ahead of print. PMID: 41145868.

Pvalb8, a Type of Oncomodulin, Regulates Neuromast Development and Auditory Function in Zebrafish

Authors:
Zhang G, Li Q, Xu Y, Zhao H, Yang C, Liu D, Gong J
Citation:
Cells. 2025 Oct 9;14(19):1572. doi: 10.3390/cells14191572. PMID: 41090799; PMCID: PMC12523338
Epub:
Not Epub
Abstract:
Congenital hearing loss, frequently resulting from defective hair cells, remains poorly understood due to the incomplete...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12523338/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang G, Li Q, Xu Y, Zhao H, Yang C, Liu D, Gong J . Pvalb8, a Type of Oncomodulin, Regulates Neuromast Development and Auditory Function in Zebrafish. Cells. 2025 Oct 9;14(19):1572. doi: 10.3390/cells14191572. PMID: 41090799; PMCID: PMC12523338.

Divergent late stage functionalisation of luminescent europium(III) complexes for targeting and imaging applications

Authors:
Cheung TL, Alexander C, Li H, Parker D
Citation:
Chem Commun (Camb). 2025 Oct 9. doi: 10.1039/d5cc04784f. Epub ahead of print. PMID: 41065065
Epub:
Not Epub
Abstract:
An efficient approach to six functionalised europium(III) complexes based on a common alkyne intermediate is exemplified by...
Link:
https://pubs.rsc.org/en/content/articlelanding/2025/cc/d5cc04784f
Delivery Method:
none
Organism or Cell Type:
cell culture: NIH-3T3 & A-549
Citation Extract:
Cheung TL, Alexander C, Li H, Parker D. Divergent late stage functionalisation of luminescent europium(III) complexes for targeting and imaging applications. Chem Commun (Camb). 2025 Oct 9. doi: 10.1039/d5cc04784f. Epub ahead of print. PMID: 41065065.

Intravesical Instillation with Vivo-Morpholino Nerve Growth Factor Antisense Therapy Ameliorates Acute Interstitial Cystitis/Painful Bladder Syndrome-Related Urinary Frequency in a Rat Model

Authors:
Chen YH, Chen WC, Liu PL, Chen HY
Citation:
Int Urogynecol J. 2025 Oct 25. doi: 10.1007/s00192-025-06394-6. Epub ahead of print. PMID: 41137924
Epub:
Not Epub
Abstract:
Introduction and hypothesis: Increased nerve growth factor (NGF) expression in the bladder is known to contribute to the...
Link:
https://link.springer.com/article/10.1007/s00192-025-06394-6
Delivery Method:
Vivo-Morpholino, intravesical instillation
Organism or Cell Type:
IC/PBS rat
Citation Extract:
Chen YH, Chen WC, Liu PL, Chen HY. Intravesical Instillation with Vivo-Morpholino Nerve Growth Factor Antisense Therapy Ameliorates Acute Interstitial Cystitis/Painful Bladder Syndrome-Related Urinary Frequency in a Rat Model. Int Urogynecol J. 2025 Oct 25. doi: 10.1007/s00192-025-06394-6. Epub ahead of print. PMID: 41137924.

Repeated intracisternal magna delivery of antisense oligonucleotides improves behavioural outcome in the dystrophic mdx23 mouse

Authors:
Aghaeipour A, Mitsogiannis, Fergus C, Tetorou K, Gileadi TE, Stojek E, Talavera S, Singh S, Siddle M, Prendeville JA, Sokolowska E, Kelly VP, Morgan JE, Montanaro F, Muntoni F
Citation:
Molecular Therapy Nucleic Acids, 2025, 102750, ISSN 2162-2531, https://doi.org/10.1016/j.omtn.2025.102750
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder caused by mutations in the DMD gene that disrupt the...
Link:
https://www.sciencedirect.com/science/article/pii/S216225312500304X
Delivery Method:
intracisternal magna (i.c.m.) injection
Organism or Cell Type:
mdx23 mice
Citation Extract:
Aghaeipour A, Mitsogiannis, Fergus C, Tetorou K, Gileadi TE, Stojek E, Talavera S, Singh S, Siddle M, Prendeville JA, Sokolowska E, Kelly VP, Morgan JE, Montanaro F, Muntoni F. Repeated intracisternal magna delivery of antisense oligonucleotides improves behavioural outcome in the dystrophic mdx23 mouse. Molecular Therapy Nucleic Acids, 2025, 102750, ISSN 2162-2531, https://doi.org/10.1016/j.omtn.2025.102750.

CMTR1 directs mitochondrial dynamics during T cell activation through epitranscriptomic regulation of splice isoforms

Authors:
Galloway A, Knop K, Gomez-Moreira C, Xavier V, Thomson S, Yoshikawa H, Suska O, Lukoszek R, Kaskar A, Lamond AI, MacVicar T, Cowling VH
Citation:
Cell Rep. 2025 Oct 13;44(10):116412. doi: 10.1016/j.celrep.2025.116412. Epub ahead of print. PMID: 41091598
Epub:
Not Epub
Abstract:
During T cell activation, mitochondrial biogenesis and cellular metabolism are altered to meet the elevated energy demands of...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01183-0
Delivery Method:
electroporation
Organism or Cell Type:
naive CD4+ T cells
Citation Extract:
Galloway A, Knop K, Gomez-Moreira C, Xavier V, Thomson S, Yoshikawa H, Suska O, Lukoszek R, Kaskar A, Lamond AI, MacVicar T, Cowling VH. CMTR1 directs mitochondrial dynamics during T cell activation through epitranscriptomic regulation of splice isoforms. Cell Rep. 2025 Oct 13;44(10):116412. doi: 10.1016/j.celrep.2025.116412. Epub ahead of print. PMID: 41091598.

polr2i is Required for Zebrafish Early Cardiac Development

Authors:
Chen Y, Zhang Q, Peng X, Wang X, Cao H, Chen Q, Huang S, Lei Y
Citation:
Front. Biosci. (Landmark Ed) 2025, 30(10), 44633. https://doi.org/10.31083/FBL44633
Epub:
Not Epub
Abstract:
Background: Congenital heart disease (CHD) is characterized by structural and functional anomalies of the heart and major...
Link:
https://www.imrpress.com/journal/FBL/30/10/10.31083/FBL44633
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen Y, Zhang Q, Peng X, Wang X, Cao H, Chen Q, Huang S, Lei Y. polr2i is Required for Zebrafish Early Cardiac Development. Front. Biosci. (Landmark Ed) 2025, 30(10), 44633. https://doi.org/10.31083/FBL44633 .

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