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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10393 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

A novel Golgi-associated Vangl2 translational variant required for PCP regulation in vertebrates

Authors:
Walton A, Revinski D, Serge A, Audebert S, Camoin L, Puvirajesinghe TM, Isnardon D, Marchetto S, Kodjabachian L, Bailly E, Borg J-P
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.10.20.347385
Abstract:
First described in Drosophila melanogaster, planar cell polarity (PCP) is a developmental process essential for embryogenesis...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Walton A, Revinski D, Serge A, Audebert S, Camoin L, Puvirajesinghe TM, Isnardon D, Marchetto S, Kodjabachian L, Bailly E, Borg J-P. A novel Golgi-associated Vangl2 translational variant required for PCP regulation in vertebrates. bioRxiv. 2020;[preprint] doi:10.1101/2020.10.20.347385 .

Effect of Mutated ids Overexpression on IDS Enzyme Activity and Developmental Phenotypes in Zebrafish Embryos: A Valuable Index for Assessing Critical Point-Mutations Associated with Mucopolysaccharidosis Type II Occurrence in Humans

Authors:
Lin C-Y, Lin H-Y, Chuang C-K, Zhang P-H, Tu 4 R-Y, Lin S-P, Tsai H-J
Citation:
Diagnostics. 2020;10(10):854 doi:10.3390/diagnostics10100854
Abstract:
Mucopolysaccharidosis type II (MPS II) is an X-linked disorder resulting from a deficiency in iduronate 2-sulfatase (IDS),...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin C-Y, Lin H-Y, Chuang C-K, Zhang P-H, Tu 4 R-Y, Lin S-P, Tsai H-J. Effect of Mutated ids Overexpression on IDS Enzyme Activity and Developmental Phenotypes in Zebrafish Embryos: A Valuable Index for Assessing Critical Point-Mutations Associated with Mucopolysaccharidosis Type II Occurrence in Humans. Diagnostics. 2020;10(10):854 doi:10.3390/diagnostics10100854.

The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models

Authors:
Klems A, van Rijssel J, Ramms AS, Wild R, Hammer J, Merkel M, Derenbach L, Préau L, Hinkel R, Suarez-Martinez I, Schulte-Merker S, Vidal R, Sauer S, Kivelä R, Alitalo K, Kupatt C, van Buul JD, le Noble F
Citation:
Nat Comm. 2020;11(1):5319. doi:10.1038/s41467-020-19008-0
Abstract:
Arterial networks enlarge in response to increase in tissue metabolism to facilitate flow and nutrient delivery. Typically, the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Klems A, van Rijssel J, Ramms AS, Wild R, Hammer J, Merkel M, Derenbach L, Préau L, Hinkel R, Suarez-Martinez I, Schulte-Merker S, Vidal R, Sauer S, Kivelä R, Alitalo K, Kupatt C, van Buul JD, le Noble F. The GEF Trio controls endothelial cell size and arterial remodeling downstream of Vegf signaling in both zebrafish and cell models. Nat Comm. 2020;11(1):5319. doi:10.1038/s41467-020-19008-0.

Slc39a5-mediated zinc homeostasis plays an essential role in venous angiogenesis in zebrafish

Authors:
Xia Z, Bi X, Lian J, Dai W, He X, Zhao L, Min J, Wang F
Citation:
Open Biol. 2020 Oct;10(10):200281. doi: 10.1098/rsob.200281. Epub 2020 Oct 21
Abstract:
Angiogenesis is a precise process mediated by a variety of signals and the environmental niche. Although the essential trace...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xia Z, Bi X, Lian J, Dai W, He X, Zhao L, Min J, Wang F. Slc39a5-mediated zinc homeostasis plays an essential role in venous angiogenesis in zebrafish. Open Biol. 2020 Oct;10(10):200281. doi: 10.1098/rsob.200281. Epub 2020 Oct 21.

Visualisation of cholesterol and ganglioside GM1 in zebrafish models of Niemann-Pick type C disease and Smith-Lemli-Opitz syndrome using light sheet microscopy

Authors:
Cook SR, Bladen C, Smith J, Maguire E, Copner J, Fenn GD, Wager K, Waller-Evans H, Lloyd-Evans E
Citation:
Histochem Cell Biol. 2020 Oct 20. doi: 10.1007/s00418-020-01925-2. Online ahead of print
Abstract:
Lysosomal storage diseases are the most common cause of neurodegeneration in children. They are characterised at the cellular...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cook SR, Bladen C, Smith J, Maguire E, Copner J, Fenn GD, Wager K, Waller-Evans H, Lloyd-Evans E. Visualisation of cholesterol and ganglioside GM1 in zebrafish models of Niemann-Pick type C disease and Smith-Lemli-Opitz syndrome using light sheet microscopy. Histochem Cell Biol. 2020 Oct 20. doi: 10.1007/s00418-020-01925-2. Online ahead of print.

Unravelling the disease mechanism for TSPYL1 deficiency

Authors:
Buyse G, Di Michele M, Wijgaerts A, Louwette S, Wittevrongel C, Thys C, Downes K, Ceulemans B, Van Esch H, Van Geet C, Freson K
Citation:
Hum Mol Genet. 2020;[Epub aheaed of print] doi:10.1093/hmg/ddaa233
Abstract:
We describe a lethal combined nervous and reproductive systems disease in three affected siblings of a consanguineous family....
Organism or Cell Type:
zebrafish
Citation Extract:
Buyse G, Di Michele M, Wijgaerts A, Louwette S, Wittevrongel C, Thys C, Downes K, Ceulemans B, Van Esch H, Van Geet C, Freson K. Unravelling the disease mechanism for TSPYL1 deficiency. Hum Mol Genet. 2020;[Epub aheaed of print] doi:10.1093/hmg/ddaa233.

setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals

Authors:
Liu D-J, Zhang F, Chen Y, Jin Y, Zhang Y-L, Chen S-B, Xie Y-Y, Huang Q-H, Zhao W-L, Wang L, Xu P-F, Chen Z, Chen S-J, Li B, Zhang A, Sun X-J
Citation:
Cell Discov. 2020;6(1):72 doi:10.1038/s41421-020-00203-8
Abstract:
Setd2 is the only enzyme that catalyzes histone H3 lysine 36 trimethylation (H3K36me3) on virtually all actively transcribed...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu D-J, Zhang F, Chen Y, Jin Y, Zhang Y-L, Chen S-B, Xie Y-Y, Huang Q-H, Zhao W-L, Wang L, Xu P-F, Chen Z, Chen S-J, Li B, Zhang A, Sun X-J. setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals. Cell Discov. 2020;6(1):72 doi:10.1038/s41421-020-00203-8.

Hmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and Lateral Line Development

Authors:
England SJ, Cerda GA, Kowalchuk A, Sorice T, Grieb G, Lewis KE
Citation:
Genetics. 2020;[Epub ahead of print] doi:10.1534/genetics.120.303748
Abstract:
Transcription factors that contain a homeodomain DNA-binding domain have crucial functions in most aspects of cellular function...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
England SJ, Cerda GA, Kowalchuk A, Sorice T, Grieb G, Lewis KE. Hmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and Lateral Line Development. Genetics. 2020;[Epub ahead of print] doi:10.1534/genetics.120.303748.

The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG

Authors:
Landgraf K, Klöting N, Gericke M, Maixner N, Guiu-Jurado E, Scholz M, Witte AV, Beyer F, Schwartze JT, Lacher M, Villringer A, Kovacs P, Rudich A, Blüher M, Kiess W, Körner A
Citation:
Cell Rep. 2020;33(3):108295. doi:10.1016/j.celrep.2020.108295
Abstract:
TMEM18 is the strongest candidate for childhood obesity identified from GWASs, yet as for most GWAS-derived obesity-...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Landgraf K, Klöting N, Gericke M, Maixner N, Guiu-Jurado E, Scholz M, Witte AV, Beyer F, Schwartze JT, Lacher M, Villringer A, Kovacs P, Rudich A, Blüher M, Kiess W, Körner A. The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG. Cell Rep. 2020;33(3):108295. doi:10.1016/j.celrep.2020.108295.

AIBP-CAV1-VEGFR3 axis dictates lymphatic cell fate and controls lymphangiogenesis

Authors:
Yang X, Kim J, Gu Q, Yan Q, Astin J, Crosier P, Yu P, Rockson SG, Fang L
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.10.16.342998
Abstract:
The lymphatics are essential for the maintenance of tissue fluid homeostasis. Accordingly, lymphatic dysfunction contributes to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang X, Kim J, Gu Q, Yan Q, Astin J, Crosier P, Yu P, Rockson SG, Fang L. AIBP-CAV1-VEGFR3 axis dictates lymphatic cell fate and controls lymphangiogenesis. bioRxiv. 2020;[preprint] doi:10.1101/2020.10.16.342998.

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