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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10227 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Evidence for RPE65-independent vision in the cone-dominated zebrafish retina

Authors:
Schonthaler HB, Lampert JM, Isken A, Rinner O, Mader A, Gesemann M, Oberhauser V, Golczak M, Biehlmaier O, Palczewski K, Neuhauss SCF, von Lintig J
Citation:
Eur J Neurosci. 2007;26(7):1940-9. doi:0.1111/j.1460-9568.2007.05801.x
Abstract:
An enzyme-based cyclic pathway for trans to cis isomerization of the chromophore of visual pigments (11-cis-...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Schonthaler HB, Lampert JM, Isken A, Rinner O, Mader A, Gesemann M, Oberhauser V, Golczak M, Biehlmaier O, Palczewski K, Neuhauss SCF, von Lintig J. Evidence for RPE65-independent vision in the cone-dominated zebrafish retina. Eur J Neurosci. 2007;26(7):1940-9. doi:0.1111/j.1460-9568.2007.05801.x.

Grp94 regulates the recruitment of aneural AChR clusters for the assembly of postsynaptic specializations by modulating ADF/cofilin activity and turnover

Authors:
Chan ZC-K, Deng L, Lee CW
Citation:
eNeuro. 2020;[Epub early release] doi:10.1523/ENEURO.0025-20.2020
Abstract:
Temperature is a physiological factor that affects neuronal growth and synaptic homeostasis at the invertebrate neuromuscular...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Chan ZC-K, Deng L, Lee CW. Grp94 regulates the recruitment of aneural AChR clusters for the assembly of postsynaptic specializations by modulating ADF/cofilin activity and turnover. eNeuro. 2020;[Epub early release] doi:10.1523/ENEURO.0025-20.2020.

Twisting of the heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process

Authors:
Tessadori F, Kruse F, van den Brink SC, van den Boogaard M, Christoffels VM, Bakkers J
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.03.230359
Abstract:
Organ laterality refers to the Left-Right (LR) asymmetry in disposition and conformation of internal organs, established in the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tessadori F, Kruse F, van den Brink SC, van den Boogaard M, Christoffels VM, Bakkers J. Twisting of the heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.03.230359 .

Functional Predictors of Causative Cis-Regulatory Mutations in Mendelian Disease

Authors:
Bengani H, Grozeva D, Moyon L, Bhatia S, Louros SR, Hope J, Jackson A, Prendergast JG, Owen LJ, Naville M, Rainger J, Grimes G, Halachev M, Murphy LC, Spasic-Boskovic O, van Heyningen V, Kind P, Abbott CM, Osterweil E, Raymond FL, Crollius HR, FitzPatrick DR
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.08.03.232926
Abstract:
Undiagnosed neurodevelopmental disease is significantly associated with rare variants in cis-regulatory elements (CRE) but...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bengani H, Grozeva D, Moyon L, Bhatia S, Louros SR, Hope J, Jackson A, Prendergast JG, Owen LJ, Naville M, Rainger J, Grimes G, Halachev M, Murphy LC, Spasic-Boskovic O, van Heyningen V, Kind P, Abbott CM, Osterweil E, Raymond FL, Crollius HR, FitzPatrick DR. Functional Predictors of Causative Cis-Regulatory Mutations in Mendelian Disease. bioRxiv. 2020;[preprint] doi:10.1101/2020.08.03.232926 .

Genome-wide RNA interference screening reveals a COPI-MAP2K3 pathway required for YAP regulation

Authors:
Kim YJ, Jung E, Shin E, Hong S-H, Jeong HS, Hur G, Jeong HY, Lee S-H, Lee JE, Kim G-H, Kim J
Citation:
Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.1915387117
Abstract:
The transcriptional regulator YAP, which plays important roles in the development, regeneration, and tumorigenesis, is...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kim YJ, Jung E, Shin E, Hong S-H, Jeong HS, Hur G, Jeong HY, Lee S-H, Lee JE, Kim G-H, Kim J. Genome-wide RNA interference screening reveals a COPI-MAP2K3 pathway required for YAP regulation. Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.1915387117.

Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish

Authors:
Yan C, Huo X, Wang S, Feng Y, Gong Z
Citation:
J Hepatol. 2015 Aug;63(2):420-8. doi: 10.1016/j.jhep.2015.03.024. Epub 2015 Mar 28
Abstract:
Background & aims: Chronic inflammation is a major etiological factor for hepatocellular carcinoma (HCC), but how immune...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yan C, Huo X, Wang S, Feng Y, Gong Z. Stimulation of hepatocarcinogenesis by neutrophils upon induction of oncogenic kras expression in transgenic zebrafish. J Hepatol. 2015 Aug;63(2):420-8. doi: 10.1016/j.jhep.2015.03.024. Epub 2015 Mar 28.

Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation

Authors:
Bernut A, Loynes CA, Floto RA, Renshaw SA
Citation:
Front Immunol. 2020;11:1733 doi:10.3389/fimmu.2020.01733
Abstract:
Inflammation-related progressive lung destruction is the leading causes of premature death in cystic fibrosis (CF), a genetic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bernut A, Loynes CA, Floto RA, Renshaw SA. Deletion of cftr Leads to an Excessive Neutrophilic Response and Defective Tissue Repair in a Zebrafish Model of Sterile Inflammation. Front Immunol. 2020;11:1733 doi:10.3389/fimmu.2020.01733.

Zfp36l1b protects angiogenesis through Notch1b/Dll4 and Vegfa regulation in zebrafish

Authors:
Hu Y-X, Zhu R-F, Qin Y-W, Zhao X-X, Jing Q
Citation:
Atherosclerosis. 2020;[Epub ahead of print] doi:10.1016/j.atherosclerosis.2020.07.021
Abstract:
Background and aim: Angiogenesis is a key process for establishing functional vasculature during embryogenesis and involves...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hu Y-X, Zhu R-F, Qin Y-W, Zhao X-X, Jing Q. Zfp36l1b protects angiogenesis through Notch1b/Dll4 and Vegfa regulation in zebrafish. Atherosclerosis. 2020;[Epub ahead of print] doi:10.1016/j.atherosclerosis.2020.07.021.

Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice

Authors:
Korecka JA, Thomas R, Hinrich AJ, Moskites AM, Macbain ZK, Hallett PJ, Isacson O, Hastings ML
Citation:
Mol Ther Nucleic Acids. 2020 Jun 27;21:623-635. doi: 10.1016/j.omtn.2020.06.027. Online ahead of print
Abstract:
Parkinson's disease (PD) is a progressive neurological disorder estimated to affect 7-10 million people worldwide. There...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: patient-derived fibroblasts
Citation Extract:
Korecka JA, Thomas R, Hinrich AJ, Moskites AM, Macbain ZK, Hallett PJ, Isacson O, Hastings ML. Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice. Mol Ther Nucleic Acids. 2020 Jun 27;21:623-635. doi: 10.1016/j.omtn.2020.06.027. Online ahead of print.

Congenital sensorineural hearing loss as the initial presentation of PTPN11-associated Noonan syndrome with multiple lentigines or Noonan syndrome: clinical features and underlying mechanisms

Authors:
Gao X, Huang SS, Qiu SW, Su Y, Wang WQ, Xu HY, Xu JC, Kang DY, Dai P, Yuan YY
Citation:
J Med Genet. 2020 Jul 31:jmedgenet-2020-106892. doi: 10.1136/jmedgenet-2020-106892. Online ahead of print
Abstract:
Background: Germline variants in PTPN11 are the primary cause of Noonan syndrome with multiple lentigines (NSML) and Noonan...
Organism or Cell Type:
zebrafish
Citation Extract:
Gao X, Huang SS, Qiu SW, Su Y, Wang WQ, Xu HY, Xu JC, Kang DY, Dai P, Yuan YY. Congenital sensorineural hearing loss as the initial presentation of PTPN11-associated Noonan syndrome with multiple lentigines or Noonan syndrome: clinical features and underlying mechanisms. J Med Genet. 2020 Jul 31:jmedgenet-2020-106892. doi: 10.1136/jmedgenet-2020-106892. Online ahead of print.

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