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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12547 scientific papers returned from the database with the search filters currently being used below.

Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis

Authors:
Xia J, Shen L, Liu Y, Wang L, Liu F
Citation:
Proc Natl Acad Sci U S A. 2025 Dec 9;122(49):e2515641122. doi: 10.1073/pnas.2515641122. Epub 2025 Dec 5. PMID: 41348733
Epub:
Not Epub
Abstract:
During vertebrate embryogenesis, hematopoietic stem and progenitor cells (HSPCs) originate from hemogenic endothelium (HE) in...
Link:
https://www.pnas.org/doi/10.1073/pnas.2515641122
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xia J, Shen L, Liu Y, Wang L, Liu F. Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis. Proc Natl Acad Sci U S A. 2025 Dec 9;122(49):e2515641122. doi: 10.1073/pnas.2515641122. Epub 2025 Dec 5. PMID: 41348733.

Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling

Authors:
Zhan D, Xu L, Mu W, Jin B, Feng Z, Liu S, Wu C, Luo L, Li L
Citation:
Cell Rep. 2025 Nov 25;44(11):116544. doi: 10.1016/j.celrep.2025.116544. Epub 2025 Nov 8. PMID: 41206867
Epub:
Not Epub
Abstract:
Retinal microglia originate during embryonic hematopoiesis and play an essential role in visual function. However, the...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01315-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhan D, Xu L, Mu W, Jin B, Feng Z, Liu S, Wu C, Luo L, Li L. Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling. Cell Rep. 2025 Nov 25;44(11):116544. doi: 10.1016/j.celrep.2025.116544. Epub 2025 Nov 8. PMID: 41206867.

Multiple retinoic acid pathway factors function together during development of a mollusk

Authors:
Dao TK & Lambert JD
Citation:
bioRxiv 2025.12.01.691671; doi: https://doi.org/10.64898/2025.12.01.691671
Epub:
Not Epub
Abstract:
In developing chordate embryos, the retinoic acid (RA) pathway is involved in many key developmental patterning systems....
Link:
https://www.biorxiv.org/content/10.64898/2025.12.01.691671v1.full
Delivery Method:
microinjection
Organism or Cell Type:
Tritia obsoleta (previously Ilyanassa obsoleta) gastropod
Citation Extract:
Dao TK & Lambert JD. Multiple retinoic acid pathway factors function together during development of a mollusk. bioRxiv 2025.12.01.691671; doi: https://doi.org/10.64898/2025.12.01.691671.

The role of AP2M1 in oncofetal characteristics: integrative in silico, in vitro, and in vivo analyses using zebrafish models

Authors:
Ahn S, Baek SE, Yu Y, Kim ES, Myung K, Kim YH, Oh CK
Citation:
Eur J Med Res. 2025 Dec 1. doi: 10.1186/s40001-025-03583-3. Epub ahead of print. PMID: 41327404
Epub:
Not Epub
Abstract:
Hepatocellular carcinoma (HCC) requires novel therapeutic targets, and oncofetal genes offer a promising avenue. Although the...
Link:
https://link.springer.com/article/10.1186/s40001-025-03583-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ahn S, Baek SE, Yu Y, Kim ES, Myung K, Kim YH, Oh CK. The role of AP2M1 in oncofetal characteristics: integrative in silico, in vitro, and in vivo analyses using zebrafish models. Eur J Med Res. 2025 Dec 1. doi: 10.1186/s40001-025-03583-3. Epub ahead of print. PMID: 41327404.

A 16-amino acid peptide delays the progression of motor neuron degeneration and pathogenic symptoms in ALS models

Authors:
Lin CY, Lee BC, Zhang PH, Lu SC, Chang WZ, Wang CC, Tsai HJ
Citation:
Neurotherapeutics. 2025 Nov 25:e00806. doi: 10.1016/j.neurot.2025.e00806. Epub ahead of print. PMID: 41298223
Epub:
Not Epub
Abstract:
Amyotrophic lateral sclerosis (ALS) is a progressive motor neurons (MNs) degenerative disease. Despite advancements in...
Link:
https://www.sciencedirect.com/science/article/pii/S1878747925002843
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin CY, Lee BC, Zhang PH, Lu SC, Chang WZ, Wang CC, Tsai HJ. A 16-amino acid peptide delays the progression of motor neuron degeneration and pathogenic symptoms in ALS models. Neurotherapeutics. 2025 Nov 25:e00806. doi: 10.1016/j.neurot.2025.e00806. Epub ahead of print. PMID: 41298223.

PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate

Authors:
Zhao X, Mouilleau V, Wang Y, Solak AC, Garcia JQ, Chen X, Shi X, Wilkinson CJ, Royer LA, Dong Z, Guo S
Citation:
Nat Commun. 2025 Nov 28;16(1):10728. doi: 10.1038/s41467-025-65756-2. PMID: 41315244; PMCID: PMC12663461
Epub:
Not Epub
Abstract:
Vertebrate radial glia progenitors (RGPs) balance self-renewal and differentiation through asymmetric cell division (ACD),...
Link:
https://www.nature.com/articles/s41467-025-65756-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhao X, Mouilleau V, Wang Y, Solak AC, Garcia JQ, Chen X, Shi X, Wilkinson CJ, Royer LA, Dong Z, Guo S. PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate. Nat Commun. 2025 Nov 28;16(1):10728. doi: 10.1038/s41467-025-65756-2. PMID: 41315244; PMCID: PMC12663461.

DIS3 licenses B cells for plasma cell differentiation in humans

Authors:
Miglierina E, Bouder J, Ordanoska D, Pineau M, Léonard S, Schavgoulidze A, Quéré G, Le Goff M, Bouchet M, Genebrier SA, Trinca SBS, Deleurme L, Monvoisin C, Derrier L, Dumontet C, Delpy L, Moreaux J, Corre J, Cogné M, Laffleur B
Citation:
Cell Mol Immunol. 2025 Nov 25. doi: 10.1038/s41423-025-01369-5. Epub ahead of print. PMID: 41286079
Epub:
Not Epub
Abstract:
DIS3 is the main catalytic subunit of the nuclear RNA exosome, a complex playing a crucial role in RNA processing and the...
Link:
https://www.nature.com/articles/s41423-025-01369-5
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Primary B cells from C57BL/6J crossed with 129/SvJ mice and healthy human donors; SSK41 human B cell line
Citation Extract:
Miglierina E, Bouder J, Ordanoska D, Pineau M, Léonard S, Schavgoulidze A, Quéré G, Le Goff M, Bouchet M, Genebrier SA, Trinca SBS, Deleurme L, Monvoisin C, Derrier L, Dumontet C, Delpy L, Moreaux J, Corre J, Cogné M, Laffleur B. DIS3 licenses B cells for plasma cell differentiation in humans. Cell Mol Immunol. 2025 Nov 25. doi: 10.1038/s41423-025-01369-5. Epub ahead of print. PMID: 41286079.

The neuropathy-linked protein TECPR2 is a Rab5 effector that regulates cargo recycling from early endosomes

Authors:
Paul S, Pant R, Sharma P, Walia K, Gupta S, Aseem A, Bajwa KK, George R, Varma Y, Bhatia T, Ramachandran R, Tuli A, Sharma M
Citation:
Nat Commun. 2025 Nov 26;16(1):10537. doi: 10.1038/s41467-025-65568-4. PMID: 41298403; PMCID: PMC12658116
Epub:
Not Epub
Abstract:
Small GTP-binding proteins of the Rab, Arf, and Arf-like family mediate the recruitment of their effectors to subcellular...
Link:
https://www.nature.com/articles/s41467-025-65568-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Paul S, Pant R, Sharma P, Walia K, Gupta S, Aseem A, Bajwa KK, George R, Varma Y, Bhatia T, Ramachandran R, Tuli A, Sharma M. The neuropathy-linked protein TECPR2 is a Rab5 effector that regulates cargo recycling from early endosomes. Nat Commun. 2025 Nov 26;16(1):10537. doi: 10.1038/s41467-025-65568-4. PMID: 41298403; PMCID: PMC12658116.

Machine learning-driven glycolytic subtyping and exosome-based PKM splicing modulation overcome drug resistance in hyper-glycolytic myeloid leukemia

Authors:
Zhong F, Chen S, Yao F, Liu J, Zhang J, Jiang J, Bai Q, Wang Z, Zhang L, Liu L, Jiang X, Huo S, Wang X, Huang B
Citation:
npj Digit. Med. (2025). https://doi.org/10.1038/s41746-025-02185-x
Epub:
Not Epub
Abstract:
This study comprehensively investigates the role of glycolysis in acute myeloid leukemia (AML) pathogenesis. Elevated...
Link:
https://www.nature.com/articles/s41746-025-02185-x
Delivery Method:
exosome-loaded Vivo-Morpholino; intratumoral (i.t.) or intravenous (i.v.) injection
Organism or Cell Type:
chronic myeloid leukemia xenograft
Citation Extract:
Zhong F, Chen S, Yao F, Liu J, Zhang J, Jiang J, Bai Q, Wang Z, Zhang L, Liu L, Jiang X, Huo S, Wang X, Huang B. Machine learning-driven glycolytic subtyping and exosome-based PKM splicing modulation overcome drug resistance in hyper-glycolytic myeloid leukemia. npj Digit. Med. (2025). https://doi.org/10.1038/s41746-025-02185-x.

Production of offspring via the transplantation of frozen germ cells from Tokyo bitterling, a fish on the brink of extinction

Authors:
Yamakawa K, Kawaguchi K, Yoshizaki G
Citation:
Sci Rep. 2025 Nov 19;15(1):40759. doi: 10.1038/s41598-025-24449-y. PMID: 41258175; PMCID: PMC12630933
Epub:
Not Epub
Abstract:
Many freshwater fish face extinctions due to habitat destruction and overfishing. Bitterlings, which lay their eggs in the gill...
Link:
https://www.nature.com/articles/s41598-025-24449-y
Delivery Method:
microinjection
Organism or Cell Type:
Tokyo bitterling
Citation Extract:
Yamakawa K, Kawaguchi K, Yoshizaki G. Production of offspring via the transplantation of frozen germ cells from Tokyo bitterling, a fish on the brink of extinction. Sci Rep. 2025 Nov 19;15(1):40759. doi: 10.1038/s41598-025-24449-y. PMID: 41258175; PMCID: PMC12630933.

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