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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12176 scientific papers returned from the database with the search filters currently being used below.

Role of Glutamate Receptor-Related Genes in Myopia Occurrence and Visual Development

Authors:
Wang R, Tao D, Lu J, Li J, Liu X, Chen C
Citation:
Curr Eye Res. 2026 Mar 10:1-11. doi: 10.1080/02713683.2026.2637650. Epub ahead of print. PMID: 41804850
Epub:
Not Epub
Abstract:
Purpose: Abnormal expression of glutamate receptors is believed to be associated with myopia. However, it is currently unclear...
Link:
https://www.tandfonline.com/doi/full/10.1080/02713683.2026.2637650
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang R, Tao D, Lu J, Li J, Liu X, Chen C. Role of Glutamate Receptor-Related Genes in Myopia Occurrence and Visual Development. Curr Eye Res. 2026 Mar 10:1-11. doi: 10.1080/02713683.2026.2637650. Epub ahead of print. PMID: 41804850.

TRIM7-mediated autophagy-lysosomal signaling is essential for preimplantation development in mice

Authors:
Khan S, Yan F, Li W, Guo J, Gu X, Tang Z, Bibi U, Dong X, Chen L, Yao Y, Xu J
Citation:
J Transl Med. 2026 Mar 17. doi: 10.1186/s12967-026-07963-z. Epub ahead of print. PMID: 41845426
Epub:
Not Epub
Abstract:
Background: Pre-implantation development in mammals requires precise coordination of zygote genome activation (ZGA), cleavage...
Link:
https://link.springer.com/article/10.1186/s12967-026-07963-z
Delivery Method:
Vivo-Morpholino culture
Organism or Cell Type:
mouse zygote
Citation Extract:
Khan S, Yan F, Li W, Guo J, Gu X, Tang Z, Bibi U, Dong X, Chen L, Yao Y, Xu J. TRIM7-mediated autophagy-lysosomal signaling is essential for preimplantation development in mice. J Transl Med. 2026 Mar 17. doi: 10.1186/s12967-026-07963-z. Epub ahead of print. PMID: 41845426.

PPMO-based exon skipping therapy improves respiratory function in the mdx mouse model of Duchenne muscular dystrophy

Authors:
Biswas DD, Rodriguez MYH, El Haddad L, Hoffmann G, Copson E, Mayman S, Jose J, Lang S, Chen O, Dela Pena A, Levin E, Abdelbarr M, Slyne A, ElMallah MK
Citation:
Mol Ther Nucleic Acids. 2025 Dec 26;37(1):102810. doi: 10.1016/j.omtn.2025.102810. PMID: 41552386; PMCID: PMC12809079
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder caused by a deficiency of dystrophin, leading to...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(25)00364-6
Delivery Method:
peptide-linked, intravenous (i.v.) injection
Organism or Cell Type:
mdx mice
Citation Extract:
Biswas DD, Rodriguez MYH, El Haddad L, Hoffmann G, Copson E, Mayman S, Jose J, Lang S, Chen O, Dela Pena A, Levin E, Abdelbarr M, Slyne A, ElMallah MK. PPMO-based exon skipping therapy improves respiratory function in the mdx mouse model of Duchenne muscular dystrophy. Mol Ther Nucleic Acids. 2025 Dec 26;37(1):102810. doi: 10.1016/j.omtn.2025.102810. PMID: 41552386; PMCID: PMC12809079.

Stereocontrolled Synthesis of Dimethylamino Phosphorochloridate Monomers toward Stereopure Phosphorodiamidate Morpholino Oligonucleotides

Authors:
Inutake R, Hasegawa H, Tsurusaki T, Sakamoto T, Sato K, Wada T
Citation:
J Org Chem. 2026 Mar 11. doi: 10.1021/acs.joc.5c02914. Epub ahead of print. PMID: 41814639
Epub:
Not Epub
Abstract:
As antisense oligonucleotides, phosphorodiamidate morpholino oligonucleotides (PMOs) exhibit excellent properties. However,...
Link:
https://pubs.acs.org/doi/10.1021/acs.joc.5c02914
Delivery Method:
None
Organism or Cell Type:
None
Citation Extract:
Inutake R, Hasegawa H, Tsurusaki T, Sakamoto T, Sato K, Wada T. Stereocontrolled Synthesis of Dimethylamino Phosphorochloridate Monomers toward Stereopure Phosphorodiamidate Morpholino Oligonucleotides. J Org Chem. 2026 Mar 11. doi: 10.1021/acs.joc.5c02914. Epub ahead of print. PMID: 41814639.

Polysorbates' effects on molecular and thermodynamic properties of phosphorodiamidate morpholino oligonucleotides' structures

Authors:
Kliuchnikov E, Pierson D, Chou Y, DiLuzio W, Marx KA, Chanda A, Barsegov V
Citation:
Mol Ther Nucleic Acids. 2026 Jan 24;37(1):102845. doi: 10.1016/j.omtn.2026.102845. PMID: 41717288; PMCID: PMC12914542
Epub:
Not Epub
Abstract:
Elucidating the structure-function relationships of phosphorodiamidate morpholino oligonucleotides (PMOs) is challenging due to...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(26)00016-8
Delivery Method:
None
Organism or Cell Type:
None
Citation Extract:
Kliuchnikov E, Pierson D, Chou Y, DiLuzio W, Marx KA, Chanda A, Barsegov V. Polysorbates' effects on molecular and thermodynamic properties of phosphorodiamidate morpholino oligonucleotides' structures. Mol Ther Nucleic Acids. 2026 Jan 24;37(1):102845. doi: 10.1016/j.omtn.2026.102845. PMID: 41717288; PMCID: PMC12914542.

A novel zebrafish model unveils folate deficiency disrupts embryonic development via p53-driven cell cycle arrest

Authors:
Zhu K, Liu H, Zhou K, Cheng T, Mo L, Xu PF, Li Y
Citation:
J Adv Res. 2026 Mar 5:S2090-1232(26)00188-8. doi: 10.1016/j.jare.2026.02.054. Epub ahead of print. PMID: 41794221
Epub:
Not Epub
Abstract:
Introduction: Folate (vitamin B9) is a fundamental cofactor in one-carbon metabolism, essential for embryonic development....
Link:
https://www.sciencedirect.com/science/article/pii/S2090123226001888
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhu K, Liu H, Zhou K, Cheng T, Mo L, Xu PF, Li Y. A novel zebrafish model unveils folate deficiency disrupts embryonic development via p53-driven cell cycle arrest. J Adv Res. 2026 Mar 5:S2090-1232(26)00188-8. doi: 10.1016/j.jare.2026.02.054. Epub ahead of print. PMID: 41794221.

Microbe-associated molecular patterns differentially mediate carcinogenic alterations of the breast tissue in the context of obesity

Authors:
Gaber M, Moulden LM, Wilson AS, Payne V, Holmes J, Neary K, Peoples A, Duet ML, Katz AJ, Vidi PA, Cook KL
Citation:
Neoplasia. 2026 Mar;73:101284. doi: 10.1016/j.neo.2026.101284. Epub 2026 Feb 17. PMID: 41707315; PMCID: PMC12925586
Epub:
Not Epub
Abstract:
Obesity is a risk factor for breast cancer. Obesity alters the microbiome and microbiome perturbations are reported in breast...
Link:
https://www.sciencedirect.com/science/article/pii/S1476558626000138
Delivery Method:
intraperitoneal (i.p.) injection
Organism or Cell Type:
C57BL/6 mice
Citation Extract:
Gaber M, Moulden LM, Wilson AS, Payne V, Holmes J, Neary K, Peoples A, Duet ML, Katz AJ, Vidi PA, Cook KL. Microbe-associated molecular patterns differentially mediate carcinogenic alterations of the breast tissue in the context of obesity. Neoplasia. 2026 Mar;73:101284. doi: 10.1016/j.neo.2026.101284. Epub 2026 Feb 17. PMID: 41707315; PMCID: PMC12925586.

Bisphenol A disrupts circadian locomotor rhythms via m6A-dependent nr1d1 destabilization in zebrafish larvae

Authors:
Kong WY, Chen PY, Shen O, Cai YN, Liu WX, Li XJ, Lu SZ, Bian W, Wang H, Wang YH, Wu LJ, Ji C, Song XY, Zhang J
Citation:
Ecotoxicol Environ Saf. 2026 Mar 7;313:119887. doi: 10.1016/j.ecoenv.2026.119887. Epub ahead of print. PMID: 41797106
Epub:
Not Epub
Abstract:
Bisphenol A (BPA), an environmental endocrine disruptor, has been shown to disrupt circadian rhythms and affect neurological...
Link:
https://www.sciencedirect.com/science/article/pii/S0147651326002162
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kong WY, Chen PY, Shen O, Cai YN, Liu WX, Li XJ, Lu SZ, Bian W, Wang H, Wang YH, Wu LJ, Ji C, Song XY, Zhang J. Bisphenol A disrupts circadian locomotor rhythms via m6A-dependent nr1d1 destabilization in zebrafish larvae. Ecotoxicol Environ Saf. 2026 Mar 7;313:119887. doi: 10.1016/j.ecoenv.2026.119887. Epub ahead of print. PMID: 41797106.

Planar cell polarity emerges through polarized accumulation of Wnt11

Authors:
Mii Y, Suzuki M, Koyama H, Nakayama K, Takada R, Kobayashi T, Tsutsumi M, Nemoto T, Matsuyama M, Fujimori T, Takada S
Citation:
Sci Adv. 2026 Feb 27;12(9):eaea0326. doi: 10.1126/sciadv.aea0326. Epub 2026 Feb 25. PMID: 41739933; PMCID: PMC12935041
Epub:
Not Epub
Abstract:
Planar cell polarity (PCP) is established by asymmetric localization of core PCP components in each cell. Because some Wnt...
Link:
https://www.science.org/doi/10.1126/sciadv.aea0326
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Mii Y, Suzuki M, Koyama H, Nakayama K, Takada R, Kobayashi T, Tsutsumi M, Nemoto T, Matsuyama M, Fujimori T, Takada S. Planar cell polarity emerges through polarized accumulation of Wnt11. Sci Adv. 2026 Feb 27;12(9):eaea0326. doi: 10.1126/sciadv.aea0326. Epub 2026 Feb 25. PMID: 41739933; PMCID: PMC12935041.

Clec16a maintains definitive hematopoietic stem and progenitor cells via mitophagy

Authors:
Cai S, Zhang Q, Luo Q, Li H, Tao Y, Feng C, Tie R, Zeng X, Chen S, Song Z, Wang A, Hu Q, Bao J, Su Y, Chen Y, Xu H, Hu K, Ding N, Ni R, Jin R, Wu F, Li X, Yang X, Xu Y, Huang H, Lu J
Citation:
Cell Rep. 2026 Feb 18;45(3):116978. doi: 10.1016/j.celrep.2026.116978. Epub ahead of print. PMID: 41719124
Epub:
Not Epub
Abstract:
Hematopoietic stem and progenitor cells (HSPCs) arise from hemogenic endothelium via the endothelial-to-hematopoietic...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00056-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cai S, Zhang Q, Luo Q, Li H, Tao Y, Feng C, Tie R, Zeng X, Chen S, Song Z, Wang A, Hu Q, Bao J, Su Y, Chen Y, Xu H, Hu K, Ding N, Ni R, Jin R, Wu F, Li X, Yang X, Xu Y, Huang H, Lu J. Clec16a maintains definitive hematopoietic stem and progenitor cells via mitophagy. Cell Rep. 2026 Feb 18;45(3):116978. doi: 10.1016/j.celrep.2026.116978. Epub ahead of print. PMID: 41719124.

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