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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12543 scientific papers returned from the database with the search filters currently being used below.

A 16-amino acid peptide delays the progression of motor neuron degeneration and pathogenic symptoms in ALS models

Authors:
Lin CY, Lee BC, Zhang PH, Lu SC, Chang WZ, Wang CC, Tsai HJ
Citation:
Neurotherapeutics. 2025 Nov 25:e00806. doi: 10.1016/j.neurot.2025.e00806. Epub ahead of print. PMID: 41298223
Epub:
Not Epub
Abstract:
Amyotrophic lateral sclerosis (ALS) is a progressive motor neurons (MNs) degenerative disease. Despite advancements in...
Link:
https://www.sciencedirect.com/science/article/pii/S1878747925002843
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin CY, Lee BC, Zhang PH, Lu SC, Chang WZ, Wang CC, Tsai HJ. A 16-amino acid peptide delays the progression of motor neuron degeneration and pathogenic symptoms in ALS models. Neurotherapeutics. 2025 Nov 25:e00806. doi: 10.1016/j.neurot.2025.e00806. Epub ahead of print. PMID: 41298223.

PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate

Authors:
Zhao X, Mouilleau V, Wang Y, Solak AC, Garcia JQ, Chen X, Shi X, Wilkinson CJ, Royer LA, Dong Z, Guo S
Citation:
Nat Commun. 2025 Nov 28;16(1):10728. doi: 10.1038/s41467-025-65756-2. PMID: 41315244; PMCID: PMC12663461
Epub:
Not Epub
Abstract:
Vertebrate radial glia progenitors (RGPs) balance self-renewal and differentiation through asymmetric cell division (ACD),...
Link:
https://www.nature.com/articles/s41467-025-65756-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhao X, Mouilleau V, Wang Y, Solak AC, Garcia JQ, Chen X, Shi X, Wilkinson CJ, Royer LA, Dong Z, Guo S. PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate. Nat Commun. 2025 Nov 28;16(1):10728. doi: 10.1038/s41467-025-65756-2. PMID: 41315244; PMCID: PMC12663461.

DIS3 licenses B cells for plasma cell differentiation in humans

Authors:
Miglierina E, Bouder J, Ordanoska D, Pineau M, Léonard S, Schavgoulidze A, Quéré G, Le Goff M, Bouchet M, Genebrier SA, Trinca SBS, Deleurme L, Monvoisin C, Derrier L, Dumontet C, Delpy L, Moreaux J, Corre J, Cogné M, Laffleur B
Citation:
Cell Mol Immunol. 2025 Nov 25. doi: 10.1038/s41423-025-01369-5. Epub ahead of print. PMID: 41286079
Epub:
Not Epub
Abstract:
DIS3 is the main catalytic subunit of the nuclear RNA exosome, a complex playing a crucial role in RNA processing and the...
Link:
https://www.nature.com/articles/s41423-025-01369-5
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Primary B cells from C57BL/6J crossed with 129/SvJ mice and healthy human donors; SSK41 human B cell line
Citation Extract:
Miglierina E, Bouder J, Ordanoska D, Pineau M, Léonard S, Schavgoulidze A, Quéré G, Le Goff M, Bouchet M, Genebrier SA, Trinca SBS, Deleurme L, Monvoisin C, Derrier L, Dumontet C, Delpy L, Moreaux J, Corre J, Cogné M, Laffleur B. DIS3 licenses B cells for plasma cell differentiation in humans. Cell Mol Immunol. 2025 Nov 25. doi: 10.1038/s41423-025-01369-5. Epub ahead of print. PMID: 41286079.

The neuropathy-linked protein TECPR2 is a Rab5 effector that regulates cargo recycling from early endosomes

Authors:
Paul S, Pant R, Sharma P, Walia K, Gupta S, Aseem A, Bajwa KK, George R, Varma Y, Bhatia T, Ramachandran R, Tuli A, Sharma M
Citation:
Nat Commun. 2025 Nov 26;16(1):10537. doi: 10.1038/s41467-025-65568-4. PMID: 41298403; PMCID: PMC12658116
Epub:
Not Epub
Abstract:
Small GTP-binding proteins of the Rab, Arf, and Arf-like family mediate the recruitment of their effectors to subcellular...
Link:
https://www.nature.com/articles/s41467-025-65568-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Paul S, Pant R, Sharma P, Walia K, Gupta S, Aseem A, Bajwa KK, George R, Varma Y, Bhatia T, Ramachandran R, Tuli A, Sharma M. The neuropathy-linked protein TECPR2 is a Rab5 effector that regulates cargo recycling from early endosomes. Nat Commun. 2025 Nov 26;16(1):10537. doi: 10.1038/s41467-025-65568-4. PMID: 41298403; PMCID: PMC12658116.

Machine learning-driven glycolytic subtyping and exosome-based PKM splicing modulation overcome drug resistance in hyper-glycolytic myeloid leukemia

Authors:
Zhong F, Chen S, Yao F, Liu J, Zhang J, Jiang J, Bai Q, Wang Z, Zhang L, Liu L, Jiang X, Huo S, Wang X, Huang B
Citation:
npj Digit. Med. (2025). https://doi.org/10.1038/s41746-025-02185-x
Epub:
Not Epub
Abstract:
This study comprehensively investigates the role of glycolysis in acute myeloid leukemia (AML) pathogenesis. Elevated...
Link:
https://www.nature.com/articles/s41746-025-02185-x
Delivery Method:
exosome-loaded Vivo-Morpholino; intratumoral (i.t.) or intravenous (i.v.) injection
Organism or Cell Type:
chronic myeloid leukemia xenograft
Citation Extract:
Zhong F, Chen S, Yao F, Liu J, Zhang J, Jiang J, Bai Q, Wang Z, Zhang L, Liu L, Jiang X, Huo S, Wang X, Huang B. Machine learning-driven glycolytic subtyping and exosome-based PKM splicing modulation overcome drug resistance in hyper-glycolytic myeloid leukemia. npj Digit. Med. (2025). https://doi.org/10.1038/s41746-025-02185-x.

Production of offspring via the transplantation of frozen germ cells from Tokyo bitterling, a fish on the brink of extinction

Authors:
Yamakawa K, Kawaguchi K, Yoshizaki G
Citation:
Sci Rep. 2025 Nov 19;15(1):40759. doi: 10.1038/s41598-025-24449-y. PMID: 41258175; PMCID: PMC12630933
Epub:
Not Epub
Abstract:
Many freshwater fish face extinctions due to habitat destruction and overfishing. Bitterlings, which lay their eggs in the gill...
Link:
https://www.nature.com/articles/s41598-025-24449-y
Delivery Method:
microinjection
Organism or Cell Type:
Tokyo bitterling
Citation Extract:
Yamakawa K, Kawaguchi K, Yoshizaki G. Production of offspring via the transplantation of frozen germ cells from Tokyo bitterling, a fish on the brink of extinction. Sci Rep. 2025 Nov 19;15(1):40759. doi: 10.1038/s41598-025-24449-y. PMID: 41258175; PMCID: PMC12630933.

Dual origins for neural cells during development of the Clytia planula larva

Authors:
Ruggiero A, Ferraioli A, Chevalier S, Lapébie P, Girard R, Momose T, Barreau C, Houliston E
Citation:
bioRxiv [preprint] 2025.11.17.688882; doi: https://doi.org/10.1101/2025.11.17.688882
Epub:
Not Epub
Abstract:
Adult hydrozoan cnidarians undergo extensive tissue turnover, generating neural cell types including nematocytes (stinging...
Link:
https://www.biorxiv.org/content/10.1101/2025.11.17.688882v1
Delivery Method:
microinjection
Organism or Cell Type:
Clytia (Phialidium) gregarium gastrula-stage embryos
Citation Extract:
Ruggiero A, Ferraioli A, Chevalier S, Lapébie P, Girard R, Momose T, Barreau C, Houliston E. Dual origins for neural cells during development of the Clytia planula larva. bioRxiv [preprint] 2025.11.17.688882; doi: https://doi.org/10.1101/2025.11.17.688882.

Collagen processing is essential for germ cell identity

Authors:
Roman S, Oulhen N, Reyes G, Masina B, Wessel G
Citation:
Biol Open. 2025 Nov 15;14(11):bio062198. doi: 10.1242/bio.062198. Epub 2025 Nov 20. PMID: 41263153
Epub:
Not Epub
Abstract:
The extracellular matrix (ECM) is a critical component of embryonic development, providing both structural support and a...
Link:
https://journals.biologists.com/bio/article/14/11/bio062198/369875/Collagen-processing-is-essential-for-germ-cell
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Roman S, Oulhen N, Reyes G, Masina B, Wessel G. Collagen processing is essential for germ cell identity. Biol Open. 2025 Nov 15;14(11):bio062198. doi: 10.1242/bio.062198. Epub 2025 Nov 20. PMID: 41263153.

DNA methyltransferase Dnmt3ba-mediated epigenetic modulation of Integrin signaling is essential for hematopoietic stem and progenitor cell development

Authors:
Ai K, Wu Y, Liang G, Kong H, Yang X, Li N, Liu Z, Dong Y, Xu J, Zhang L, Chen X, Fu Y, Wang L, Li L
Citation:
Commun Biol. 2025 Nov 19;8(1):1612. doi: 10.1038/s42003-025-09003-w. PMID: 41261168; PMCID: PMC12630766
Epub:
Not Epub
Abstract:
In vertebrate embryonic development, hematopoietic stem and progenitor cells (HSPCs) originate from a subset of arterial...
Link:
https://www.nature.com/articles/s42003-025-09003-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ai K, Wu Y, Liang G, Kong H, Yang X, Li N, Liu Z, Dong Y, Xu J, Zhang L, Chen X, Fu Y, Wang L, Li L. DNA methyltransferase Dnmt3ba-mediated epigenetic modulation of Integrin signaling is essential for hematopoietic stem and progenitor cell development. Commun Biol. 2025 Nov 19;8(1):1612. doi: 10.1038/s42003-025-09003-w. PMID: 41261168; PMCID: PMC12630766.

A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology

Authors:
Sun J, Atiş IS, Empke SLL, Khokha MK, Breslow DK
Citation:
Dev Cell. 2025 Nov 20:S1534-5807(25)00666-5. doi: 10.1016/j.devcel.2025.10.015. Epub ahead of print. PMID: 41270742
Epub:
Not Epub
Abstract:
Microscopy offers an indispensable technique for visualizing biological processes and for defining cytological abnormalities...
Link:
https://www.cell.com/developmental-cell/fulltext/S1534-5807(25)00666-5
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Sun J, Atiş IS, Empke SLL, Khokha MK, Breslow DK. A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology. Dev Cell. 2025 Nov 20:S1534-5807(25)00666-5. doi: 10.1016/j.devcel.2025.10.015. Epub ahead of print. PMID: 41270742.

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