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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11761 scientific papers returned from the database with the search filters currently being used below.

Cartilage regeneration in zebrafish depends on Nrg1/ErbB signaling pathway

Authors:
Sapède D, Bahraoui S, Abou Nassif L, Barthelaix A, Mathieu M, Jorgensen C, Djouad F
Citation:
Front Cell Dev Biol. 2023 Apr 4;11:1123299. doi: 10.3389/fcell.2023.1123299. eCollection 2023
Epub:
Not Epub
Abstract:
Objective: Cartilage, as the majority of adult mammalian tissues, has limited regeneration capacity. Cartilage degradation...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sapède D, Bahraoui S, Abou Nassif L, Barthelaix A, Mathieu M, Jorgensen C, Djouad F. Cartilage regeneration in zebrafish depends on Nrg1/ErbB signaling pathway. Front Cell Dev Biol. 2023 Apr 4;11:1123299. doi: 10.3389/fcell.2023.1123299. eCollection 2023.

Genetic deletion of the inflammation-regulated microRNA miR-146a increases exon-skipping mediated dystrophin restoration in Duchenne muscular dystrophy

Authors:
McCormack NM, Calabrese KA, Tully CB, Heier CR, Fiorillo AA
Citation:
bioRxiv. 2023 May 9:2023.05.09.540042. doi: 10.1101/2023.05.09.540042. Preprint
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a progressive muscle disease caused by loss of function mutations in the Dystrophin gene...
Delivery Method:
intramuscular (i.m.) or intravenous (i.v.) injection
Organism or Cell Type:
mice
Citation Extract:
McCormack NM, Calabrese KA, Tully CB, Heier CR, Fiorillo AA. Genetic deletion of the inflammation-regulated microRNA miR-146a increases exon-skipping mediated dystrophin restoration in Duchenne muscular dystrophy. bioRxiv. 2023 May 9:2023.05.09.540042. doi: 10.1101/2023.05.09.540042. Preprint.

A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish

Authors:
Shin U, Choi Y, Ko HS, Myung K, Lee S, Cheon CK, Lee Y
Citation:
Hum Genomics. 2023 May 19;17(1):44. doi: 10.1186/s40246-023-00491-7
Epub:
Not Epub
Abstract:
Background: Ubiquitin-related rare diseases are generally characterized by developmental delays and mental retardation, but the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shin U, Choi Y, Ko HS, Myung K, Lee S, Cheon CK, Lee Y. A heterozygous mutation in UBE2H in a patient with developmental delay leads to an aberrant brain development in zebrafish. Hum Genomics. 2023 May 19;17(1):44. doi: 10.1186/s40246-023-00491-7.

Embryonic Ethanol but Not Cannabinoid Exposure Affects Zebrafish Cardiac Development via Agrin and Sonic Hedgehog Interaction

Authors:
Zhang C, Ezem N, Mackinnon S, Cole GJ
Citation:
Cells. 2023 May 6;12(9):1327. doi: 10.3390/cells12091327
Epub:
Not Epub
Abstract:
Recent studies demonstrate the adverse effects of cannabinoids on development, including via pathways shared with ethanol...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang C, Ezem N, Mackinnon S, Cole GJ. Embryonic Ethanol but Not Cannabinoid Exposure Affects Zebrafish Cardiac Development via Agrin and Sonic Hedgehog Interaction. Cells. 2023 May 6;12(9):1327. doi: 10.3390/cells12091327.

The challenge of dissecting gene function in model organisms: Tools to characterize genetic mutants and assess transcriptional adaptation in zebrafish

Authors:
Cardenas-Rodriguez M, Drummond IA
Citation:
Methods Cell Biol. 2023;176:1-25. doi: 10.1016/bs.mcb.2022.12.019. Epub 2023 Jan 27
Epub:
Not Epub
Abstract:
Genome editing technologies including the CRISPR/Cas9 system have greatly improved our knowledge of gene function and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cardenas-Rodriguez M, Drummond IA. The challenge of dissecting gene function in model organisms: Tools to characterize genetic mutants and assess transcriptional adaptation in zebrafish. Methods Cell Biol. 2023;176:1-25. doi: 10.1016/bs.mcb.2022.12.019. Epub 2023 Jan 27.

Role of MicroRNAs and their Downstream Target Transcription Factors in Zebrafish Thrombopoiesis

Authors:
Qaryoute AA, Fallatah W, Dhinoja S, Raman R, Jagadeeswaran P
Citation:
Res Sq. 2023 Apr 24:rs.3.rs-2807790. doi: 10.21203/rs.3.rs-2807790/v1. Preprint
Epub:
Not Epub
Abstract:
Previous studies have shown that human platelets and megakaryocytes carry microRNAs suggesting their role in platelet function...
Delivery Method:
Vivo-Morpholino piggyback
Organism or Cell Type:
zebrafish
Citation Extract:
Qaryoute AA, Fallatah W, Dhinoja S, Raman R, Jagadeeswaran P. Role of MicroRNAs and their Downstream Target Transcription Factors in Zebrafish Thrombopoiesis. Res Sq. 2023 Apr 24:rs.3.rs-2807790. doi: 10.21203/rs.3.rs-2807790/v1. Preprint.

Npr3 regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor

Authors:
Devotta A, Juraver-Geslin H, Griffin C, Saint-Jeannet JP
Citation:
Elife. 2023 May 10;12:e84036. doi: 10.7554/eLife.84036. Online ahead of print
Epub:
Yes
Abstract:
Natriuretic peptide signaling has been implicated in a broad range of physiological processes, regulating blood volume and...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Devotta A, Juraver-Geslin H, Griffin C, Saint-Jeannet JP. Npr3 regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor. Elife. 2023 May 10;12:e84036. doi: 10.7554/eLife.84036. Online ahead of print.

Efficacy and Safety of Viltolarsen in Boys With Duchenne Muscular Dystrophy: Results From the Phase 2, Open-Label, 4-Year Extension Study

Authors:
Clemens PR, Rao VK, Connolly AM, Harper AD, Mah JK, McDonald CM, Smith EC, Zaidman CM, Nakagawa T; CINRG DNHS Investigators; Hoffman EP
Citation:
J Neuromuscul Dis. 2023;10(3):439-447. doi: 10.3233/JND-221656
Epub:
Not Epub
Abstract:
Background: Duchenne muscular dystrophy (DMD) is caused by DMD gene mutations, resulting in absence of functional dystrophin...
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Clemens PR, Rao VK, Connolly AM, Harper AD, Mah JK, McDonald CM, Smith EC, Zaidman CM, Nakagawa T; CINRG DNHS Investigators; Hoffman EP. Efficacy and Safety of Viltolarsen in Boys With Duchenne Muscular Dystrophy: Results From the Phase 2, Open-Label, 4-Year Extension Study. J Neuromuscul Dis. 2023;10(3):439-447. doi: 10.3233/JND-221656.

Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ

Authors:
Chen C-l, Syahirah R, Ravala S, Yen Y-C, Klose T, Deng Q, Tesmer JJG
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.05.04.539492
Epub:
Not Epub
Abstract:
The conversion of PIP2 to PIP3 by phosphoinositide 3-kinase γ (PI3Kγ) is a critical step in neutrophil chemotaxis and is...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen C-l, Syahirah R, Ravala S, Yen Y-C, Klose T, Deng Q, Tesmer JJG. Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ. bioRxiv. 2023;[preprint] doi:10.1101/2023.05.04.539492 .

The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation

Authors:
Ding T, Ji J, Zhang W, Liu Y, Liu B, Han Y, Chen C, Yu L
Citation:
Cell Res. 2023;[Epub] doi:10.1038/s41422-023-00811-5
Epub:
Yes
Abstract:
Migrasomes are recently discovered organelles, which are formed on the ends or branch points of retraction fibers at the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ding T, Ji J, Zhang W, Liu Y, Liu B, Han Y, Chen C, Yu L. The phosphatidylinositol (4,5)-bisphosphate-Rab35 axis regulates migrasome formation. Cell Res. 2023;[Epub] doi:10.1038/s41422-023-00811-5.

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