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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12202 scientific papers returned from the database with the search filters currently being used below.

Gene body methylation suppresses intragenic transcription and permits epigenetic inheritance in a cnidarian

Authors:
Xu L, Heery R, Baranasic D, Žunar B, Segura Campaña A, Ovchinnikov V, Lenhard B, de Mendoza A
Citation:
Nat Ecol Evol. 2026 Jun 2. doi: 10.1038/s41559-026-03090-6. Epub ahead of print. PMID: 42231006
Epub:
Not Epub
Abstract:
Across invertebrates, DNA methylation is largely restricted to the bodies of highly and constitutively expressed genes. This...
Link:
https://www.nature.com/articles/s41559-026-03090-6
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (starlet sea anemone)
Citation Extract:
Xu L, Heery R, Baranasic D, Žunar B, Segura Campaña A, Ovchinnikov V, Lenhard B, de Mendoza A. Gene body methylation suppresses intragenic transcription and permits epigenetic inheritance in a cnidarian. Nat Ecol Evol. 2026 Jun 2. doi: 10.1038/s41559-026-03090-6. Epub ahead of print. PMID: 42231006.

Heme oxygenase 1 activity mediates red blood cell clearance and tail fin regeneration in zebrafish larvae

Authors:
Mirza A, Crawte S, Muñoz-Montecinos C, Mukherjee S, Lieschke GJ, Allende ML, Morales Castro RA
Citation:
Sci Rep. 2026 Jun 2;16(1):17157. doi: 10.1038/s41598-026-54996-x. PMID: 42230891
Epub:
Not Epub
Abstract:
Tissue injury triggers a tightly regulated cascade of events that transition from inflammation to resolution and ultimately...
Link:
https://www.nature.com/articles/s41598-026-54996-x
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mirza A, Crawte S, Muñoz-Montecinos C, Mukherjee S, Lieschke GJ, Allende ML, Morales Castro RA. Heme oxygenase 1 activity mediates red blood cell clearance and tail fin regeneration in zebrafish larvae. Sci Rep. 2026 Jun 2;16(1):17157. doi: 10.1038/s41598-026-54996-x. PMID: 42230891.

CDKL1 variants affecting ciliary formation predispose to thoracic aortic aneurysm and dissection

Authors:
Nauth T, Philipp M, Renner S, Burkhalter MD, Schüler H, Saygi C, Händler K, Siebels B, Busch A, Mair T, Rickassel V, Deden S, Hoffer K, Olfe J, Mir TS, von Kodolitsch Y, Girdauskas E, Rybczynski M, Kriegs M, Voß H, Sauvigny T, Spielmann M, Alawi M, Krasemann S, Kubisch C, Demal TJ, Rosenberger G
Citation:
J Clin Invest. 2025 Oct 7;135(23):e186287. doi: 10.1172/JCI186287. PMID: 41056017; PMCID: PMC12646653
Epub:
Not Epub
Abstract:
Genetic factors are fundamental in the etiology of thoracic aortic aneurysm and dissection (TAAD), but the genetic cause is...
Link:
https://www.jci.org/articles/view/186287
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nauth T, Philipp M, Renner S, Burkhalter MD, Schüler H, Saygi C, Händler K, Siebels B, Busch A, Mair T, Rickassel V, Deden S, Hoffer K, Olfe J, Mir TS, von Kodolitsch Y, Girdauskas E, Rybczynski M, Kriegs M, Voß H, Sauvigny T, Spielmann M, Alawi M, Krasemann S, Kubisch C, Demal TJ, Rosenberger G. CDKL1 variants affecting ciliary formation predispose to thoracic aortic aneurysm and dissection. J Clin Invest. 2025 Oct 7;135(23):e186287. doi: 10.1172/JCI186287. PMID: 41056017; PMCID: PMC12646653.

A protein interactome for the last eukaryotic common ancestor illuminates the biochemical basis of modern genetic diseases

Authors:
Cox RM, Papoulas O, Shril S, Lee C, Gardner TP, Ansari ZT, Battenhouse AM, Lee M, Drew K, McWhite CD, Yang D, Leggere JC, Durand D, Hildebrandt F, Wallingford JB, Marcotte EM
Citation:
Cell Genom. 2026 May 27:101254. doi: 10.1016/j.xgen.2026.101254. Epub ahead of print. PMID: 42202782
Epub:
Not Epub
Abstract:
All eukaryotes share a single-celled ancestor from ∼1.5 to 1.8 billion years ago, the so-called last eukaryotic common ancestor...
Link:
https://www.cell.com/cell-genomics/fulltext/S2666-979X(26)00116-3
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Cox RM, Papoulas O, Shril S, Lee C, Gardner TP, Ansari ZT, Battenhouse AM, Lee M, Drew K, McWhite CD, Yang D, Leggere JC, Durand D, Hildebrandt F, Wallingford JB, Marcotte EM. A protein interactome for the last eukaryotic common ancestor illuminates the biochemical basis of modern genetic diseases. Cell Genom. 2026 May 27:101254. doi: 10.1016/j.xgen.2026.101254. Epub ahead of print. PMID: 42202782.

First large-scale screening of Notch biallelic variants implicates novel candidate genes in congenital hypothyroidism

Authors:
Wu FY, Wu CY, Wang Z, Tian ZG, Song YK, Cui RJ, Yang RF, Zhang HY, Li MY, Liu XY, Zhan M, Yang L, Wu J, Dong M, Nulali JY, Zhang FX, Bao Y, Song SY, Song SH, Li R, Peng MF, Yang RM, Zhao SX, Song HD
Citation:
J Clin Endocrinol Metab. 2026 May 26:dgag208. doi: 10.1210/clinem/dgag208. Epub ahead of print. PMID: 42192612
Epub:
Not Epub
Abstract:
Context: Congenital hypothyroidism (CH) is a major preventable cause of developmental and cognitive impairment. Current genetic...
Link:
https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgag208/8695057
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu FY, Wu CY, Wang Z, Tian ZG, Song YK, Cui RJ, Yang RF, Zhang HY, Li MY, Liu XY, Zhan M, Yang L, Wu J, Dong M, Nulali JY, Zhang FX, Bao Y, Song SY, Song SH, Li R, Peng MF, Yang RM, Zhao SX, Song HD. First large-scale screening of Notch biallelic variants implicates novel candidate genes in congenital hypothyroidism. J Clin Endocrinol Metab. 2026 May 26:dgag208. doi: 10.1210/clinem/dgag208. Epub ahead of print. PMID: 42192612.

A User-Friendly Protocol for Microinjection into Teleost Embryos to Study Gene Function

Authors:
Mendoza A, Simon I, Hasan S
Citation:
Biochem Genet. 2026 May 26. doi: 10.1007/s10528-026-11400-7. Epub ahead of print. PMID: 42189436
Epub:
Not Epub
Abstract:
Zebrafish (Danio rerio) and medaka (Oryzias latipes) are popular teleost models used in developmental biology and functional...
Link:
https://link.springer.com/article/10.1007/s10528-026-11400-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish and Oryzias latipes (medaka)
Citation Extract:
Mendoza A, Simon I, Hasan S. A User-Friendly Protocol for Microinjection into Teleost Embryos to Study Gene Function. Biochem Genet. 2026 May 26. doi: 10.1007/s10528-026-11400-7. Epub ahead of print. PMID: 42189436.

Dual mechanism of human ATG10S in suppressing MEF2A-Driven pro-inflammatory responses

Authors:
Zhang MQ, Wang ZH, Zhang JP
Citation:
Autophagy. 2026 May 26:1-22. doi: 10.1080/15548627.2026.2676074. Epub ahead of print. PMID: 42144735
Epub:
Not Epub
Abstract:
Cytokine storm, characterized by excessive release of pro-inflammatory cytokines, contributes to the severity and exacerbation...
Link:
https://www.tandfonline.com/doi/full/10.1080/15548627.2026.2676074
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang MQ, Wang ZH, Zhang JP. Dual mechanism of human ATG10S in suppressing MEF2A-Driven pro-inflammatory responses. Autophagy. 2026 May 26:1-22. doi: 10.1080/15548627.2026.2676074. Epub ahead of print. PMID: 42144735.

Benzophenone-2 Disrupts Craniofacial Cartilage Development via esr2a-Dependent Inhibition of Endothelin Signaling in Zebrafish Larvae

Authors:
Xie Z, Li K, Zhou X, Wu Q, Zhou X, Zeng P, Li J, Niu Q, Qi Z, Zhao X, Song W
Citation:
Environ Res. 2026 May 22:124828. doi: 10.1016/j.envres.2026.124828. Epub ahead of print. PMID: 42176944
Epub:
Not Epub
Abstract:
Epidemiological evidence has linked early-life exposure to estrogenic endocrine-disrupting chemicals (e-EDCs) to craniofacial...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S001393512601159X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xie Z, Li K, Zhou X, Wu Q, Zhou X, Zeng P, Li J, Niu Q, Qi Z, Zhao X, Song W. Benzophenone-2 Disrupts Craniofacial Cartilage Development via esr2a-Dependent Inhibition of Endothelin Signaling in Zebrafish Larvae. Environ Res. 2026 May 22:124828. doi: 10.1016/j.envres.2026.124828. Epub ahead of print. PMID: 42176944.

Enhanced antisense oligonucleotide delivery reveals that transcript turnover impacts apparent splicing rescue in myotonic dystrophy

Authors:
Shea EN, Olafson HR, Muscato DR, Adams LM, Valero MC, McKee KK, Shen X, Dougherty PG, Hicks AN, Liu N, Kheirabadi M, Streeter M, Li X, Mon P, Girgenrath M, Sethuraman N, Qian Z, Wang ET
Citation:
Mol Ther. 2026 May 19:S1525-0016(26)00381-3. doi: 10.1016/j.ymthe.2026.04.060. Epub ahead of print. PMID: 42163456
Epub:
Not Epub
Abstract:
Steric-blocking antisense oligonucleotides rescue myotonic dystrophy type 1 phenotypes in preclinical models and are under...
Link:
https://www.cell.com/molecular-therapy-family/molecular-therapy/abstract/S1525-0016(26)00381-3
Delivery Method:
peptide-linked, intravenous (i.v.) injection
Organism or Cell Type:
HSALR mice
Citation Extract:
Shea EN, Olafson HR, Muscato DR, Adams LM, Valero MC, McKee KK, Shen X, Dougherty PG, Hicks AN, Liu N, Kheirabadi M, Streeter M, Li X, Mon P, Girgenrath M, Sethuraman N, Qian Z, Wang ET. Enhanced antisense oligonucleotide delivery reveals that transcript turnover impacts apparent splicing rescue in myotonic dystrophy. Mol Ther. 2026 May 19:S1525-0016(26)00381-3. doi: 10.1016/j.ymthe.2026.04.060. Epub ahead of print. PMID: 42163456.

Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis

Authors:
Vagena-Pantoula C, Kalyviotis K, Feng S, Sanchez A, Kondrychyn I, Fukumoto M, Pan X, Juan T, Stainier DYR, Pantazis P, Phng LK, Vermot J
Citation:
Sci Adv. 2026 Apr 24;12(17):eaea7025. doi: 10.1126/sciadv.aea7025. Epub 2026 Apr 22. PMID: 42018616; PMCID: PMC13101866
Epub:
Not Epub
Abstract:
Organ morphogenesis is driven by physical forces, yet how mechanical stimuli pattern tissue shape and guide developmental...
Link:
https://www.science.org/doi/10.1126/sciadv.aea7025
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vagena-Pantoula C, Kalyviotis K, Feng S, Sanchez A, Kondrychyn I, Fukumoto M, Pan X, Juan T, Stainier DYR, Pantazis P, Phng LK, Vermot J. Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis. Sci Adv. 2026 Apr 24;12(17):eaea7025. doi: 10.1126/sciadv.aea7025. Epub 2026 Apr 22. PMID: 42018616; PMCID: PMC13101866.

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