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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10988 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

IPIP27A cooperates with OCRL to support endocytic traffic in the zebrafish pronephric tubule

Authors:
Oltrabella F, Jackson-Crawford A, Yan G, Rixham S, Starborg T, Lowe M
Citation:
Hum Molec Genet. 2021;ddab307 [Epub] doi:10.1093/hmg/ddab307
Epub:
Yes
Abstract:
Endocytosis is a fundamentally important process through which material is internalized into cells from the extracellular...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oltrabella F, Jackson-Crawford A, Yan G, Rixham S, Starborg T, Lowe M. IPIP27A cooperates with OCRL to support endocytic traffic in the zebrafish pronephric tubule. Hum Molec Genet. 2021;ddab307 [Epub] doi:10.1093/hmg/ddab307.

A dual involvement of Protocadherin-18a in stromal cell development guides the formation of a functional hematopoietic niche

Authors:
Touret A-L, Vivier C, Schmidt A, Herbomel P, Murayama E
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.10.19.465038
Epub:
Not Epub
Abstract:
Hematopoietic stem and progenitor cells (HSPCs) emerge from the aorta and migrate to the caudal hematopoietic tissue (CHT) of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Touret A-L, Vivier C, Schmidt A, Herbomel P, Murayama E. A dual involvement of Protocadherin-18a in stromal cell development guides the formation of a functional hematopoietic niche. bioRxiv. 2021;[preprint] doi:10.1101/2021.10.19.465038 .

Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA

Authors:
Price AM, Steinbock RT, Di C, Hayer KE, Li Y, Herrmann C, Parenti NA, Whelan JN, Weiss SR, Weitzman MD
Citation:
Nucl Acids Res. 2021;[Epub]:gkab896. doi:10.1093/nar/gkab896
Epub:
Yes
Abstract:
Eukaryotic cells recognize intracellular pathogens through pattern recognition receptors, including sensors of aberrant nucleic...
Delivery Method:
Endo-Porter PEG
Organism or Cell Type:
cell culture: A549
Citation Extract:
Price AM, Steinbock RT, Di C, Hayer KE, Li Y, Herrmann C, Parenti NA, Whelan JN, Weiss SR, Weitzman MD. Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA. Nucl Acids Res. 2021;[Epub]:gkab896. doi:10.1093/nar/gkab896.

Pharmacokinetic/Pharmacodynamic Modeling of a Cell-Penetrating Peptide Phosphorodiamidate Morpholino Oligomer in mdx Mice

Authors:
Mukashyaka MC, Wu CL, Ha K, Zhang J, Wood J, Foley S, Mastis B, Jungels N, Sun H, Shadid M, Harriman S, Hadcock JR
Citation:
Pharm Res. 2021 Oct 20. doi: 10.1007/s11095-021-03118-5. Online ahead of print
Epub:
Yes
Abstract:
Purpose: Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) have shown promise in treating Duchenne muscular...
Delivery Method:
i.v. injection
Organism or Cell Type:
mice
Citation Extract:
Mukashyaka MC, Wu CL, Ha K, Zhang J, Wood J, Foley S, Mastis B, Jungels N, Sun H, Shadid M, Harriman S, Hadcock JR. Pharmacokinetic/Pharmacodynamic Modeling of a Cell-Penetrating Peptide Phosphorodiamidate Morpholino Oligomer in mdx Mice. Pharm Res. 2021 Oct 20. doi: 10.1007/s11095-021-03118-5. Online ahead of print.

An in vitro system to silence mitochondrial gene expression

Authors:
Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P
Citation:
Cell. 2021;[Epub ahead of print] doi:10.1016/j.cell.2021.09.033
Epub:
Not Epub
Abstract:
The human mitochondrial genome encodes thirteen core subunits of the oxidative phosphorylation system, and defects in...
Organism or Cell Type:
cell culture: isolated mitochondria
Citation Extract:
Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P. An in vitro system to silence mitochondrial gene expression. Cell. 2021;[Epub ahead of print] doi:10.1016/j.cell.2021.09.033.

The Proapoptotic Gene Bad Regulates Brain Development via P53-Mediated Stress Signals in Zebrafish

Authors:
Hung J-C, Wu J-L, Li H-C, Chiu H-W, Hong J-R
Citation:
Cells. 2021;10(11):2820. doi:10.3390/cells10112820
Epub:
Not Epub
Abstract:
Studies have shown that the BH3-only domain Bad regulates brain development via the control of programmed cell death (PCD), but...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hung J-C, Wu J-L, Li H-C, Chiu H-W, Hong J-R. The Proapoptotic Gene Bad Regulates Brain Development via P53-Mediated Stress Signals in Zebrafish. Cells. 2021;10(11):2820. doi:10.3390/cells10112820.

Genetic landscape of T cells identifies synthetic lethality for T-ALL

Authors:
O’Meara CP, Guerri L, Lawir D-F, Mateos F, Iconomou M, Iwanami N, Soza-Ried C, Sikora K, Siamishi I, Giorgetti O, Peter S, Schorpp M, Boehm T
Citation:
Comm Biol. 2021;4(1):1201. doi:10.1038/s42003-021-02694-x
Epub:
Not Epub
Abstract:
To capture the global gene network regulating the differentiation of immature T cells in an unbiased manner, large-scale...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
O’Meara CP, Guerri L, Lawir D-F, Mateos F, Iconomou M, Iwanami N, Soza-Ried C, Sikora K, Siamishi I, Giorgetti O, Peter S, Schorpp M, Boehm T. Genetic landscape of T cells identifies synthetic lethality for T-ALL. Comm Biol. 2021;4(1):1201. doi:10.1038/s42003-021-02694-x.

V-type H+ ATPase Activity is Required for Embryonic Dorsal-Ventral Symmetry Breaking

Authors:
Schatzberg D, Thomas CF, Reidy P, Hadyniak SE, Skidanova V, Lawton ML, Dojer L, Kitchloo S, Zuch DT, Bradham CA
Citation:
bioRxiv. 2021;[preprint]. doi:10.1101/2021.10.18.464707
Epub:
Not Epub
Abstract:
The mechanism for embryonic dorsal-ventral (DV) symmetry breaking is idiosyncratic to the species, then converges on polarized...
Delivery Method:
microinjection
Organism or Cell Type:
Lytechinus variegatus (sea urchin)
Citation Extract:
Schatzberg D, Thomas CF, Reidy P, Hadyniak SE, Skidanova V, Lawton ML, Dojer L, Kitchloo S, Zuch DT, Bradham CA. V-type H+ ATPase Activity is Required for Embryonic Dorsal-Ventral Symmetry Breaking. bioRxiv. 2021;[preprint]. doi:10.1101/2021.10.18.464707.

Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis

Authors:
Pradhan SJ, Reddy PC, Smutny M, Sharma A, Sako K, Oak MS, Shah R, Pal M, Deshpande O, Dsilva G, Tang Y, Mishra R, Deshpande G, Giraldez AJ, Sonawane M, Heisenberg C-P, Galande S
Citation:
Nat Commun. 2021;12(1):6094. doi:10.1038/s41467-021-26234-7
Epub:
Not Epub
Abstract:
Zygotic genome activation (ZGA) initiates regionalized transcription underlying distinct cellular identities. ZGA is dependent...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pradhan SJ, Reddy PC, Smutny M, Sharma A, Sako K, Oak MS, Shah R, Pal M, Deshpande O, Dsilva G, Tang Y, Mishra R, Deshpande G, Giraldez AJ, Sonawane M, Heisenberg C-P, Galande S. Satb2 acts as a gatekeeper for major developmental transitions during early vertebrate embryogenesis. Nat Commun. 2021;12(1):6094. doi:10.1038/s41467-021-26234-7.

NAMPT reduction-induced NAD+ insufficiency contributes to the compromised oocyte quality from obese mice

Authors:
Wang H, Zhu S, Wu X, Liu Y, Ge J, Wang Q, Gu L
Citation:
Aging Cell. 2021 Oct 18:e13496. doi: 10.1111/acel.13496. Online ahead of print
Epub:
Not Epub
Abstract:
Maternal obesity is associated with multiple adverse reproductive outcomes, whereas the underlying molecular mechanisms are...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Wang H, Zhu S, Wu X, Liu Y, Ge J, Wang Q, Gu L. NAMPT reduction-induced NAD+ insufficiency contributes to the compromised oocyte quality from obese mice. Aging Cell. 2021 Oct 18:e13496. doi: 10.1111/acel.13496. Online ahead of print.

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