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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11592 scientific papers returned from the database with the search filters currently being used below.

Parental mutations influence wild-type offspring via transcriptional adaptation

Authors:
Jiang Z, El-Brolosy MA, Serobyan V, Welker JM, Retzer N, Dooley CM, Jakutis G, Juan T, Fukuda N, Maischein HM, Balciunas D, Stainier DYR
Citation:
Sci Adv. 2022 Nov 25;8(47):eabj2029. doi: 10.1126/sciadv.abj2029. Epub 2022 Nov 25
Epub:
Not Epub
Abstract:
Transgenerational epigenetic inheritance (TEI) is mostly discussed in the context of physiological or environmental factors....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jiang Z, El-Brolosy MA, Serobyan V, Welker JM, Retzer N, Dooley CM, Jakutis G, Juan T, Fukuda N, Maischein HM, Balciunas D, Stainier DYR. Parental mutations influence wild-type offspring via transcriptional adaptation. Sci Adv. 2022 Nov 25;8(47):eabj2029. doi: 10.1126/sciadv.abj2029. Epub 2022 Nov 25.

Top2a promotes the development of social behavior via PRC2 and H3K27me3

Authors:
Geng Y, Zhang T, Alonzo IG, Godar SC, Yates C, Pluimer BR, Harrison DL, Nath AK, Yeh JJ, Drummond IA, Bortolato M, Peterson RT
Citation:
Sci Adv. 2022 Nov 25;8(47):eabm7069. doi: 10.1126/sciadv.abm7069. Epub 2022 Nov 23
Epub:
Not Epub
Abstract:
Little is understood about the embryonic development of sociality. We screened 1120 known drugs and found that embryonic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Geng Y, Zhang T, Alonzo IG, Godar SC, Yates C, Pluimer BR, Harrison DL, Nath AK, Yeh JJ, Drummond IA, Bortolato M, Peterson RT. Top2a promotes the development of social behavior via PRC2 and H3K27me3. Sci Adv. 2022 Nov 25;8(47):eabm7069. doi: 10.1126/sciadv.abm7069. Epub 2022 Nov 23.

Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11

Authors:
Zadra I, Jimenez-Delgado S, Anglada-Girotto M, Segura-Morales C, Compton ZJ, Janke C, Serrano L, Ruprecht V, Vernos I
Citation:
Nat Commun. 2022 Nov 21;13(1):7147. doi: 10.1038/s41467-022-34909-y
Epub:
Not Epub
Abstract:
Regulation of microtubule (MT) dynamics is key for mitotic spindle assembly and faithful chromosome segregation. Here we show...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zadra I, Jimenez-Delgado S, Anglada-Girotto M, Segura-Morales C, Compton ZJ, Janke C, Serrano L, Ruprecht V, Vernos I. Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11. Nat Commun. 2022 Nov 21;13(1):7147. doi: 10.1038/s41467-022-34909-y.

Microenvironmental Snail1 is a driver of immunosuppression in melanoma

Authors:
Arumi-Planas M, Rodriguez-Baena FJ, Cabello-Torres F, Gracia F, Lopez-Blau C, Nieto MA, Sanchez-Laorden B
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.11.23.517623
Epub:
Not Epub
Abstract:
Melanoma is an aggressive form of skin cancer due to its high metastatic abilities and resistance to therapies. Melanoma cells...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Arumi-Planas M, Rodriguez-Baena FJ, Cabello-Torres F, Gracia F, Lopez-Blau C, Nieto MA, Sanchez-Laorden B. Microenvironmental Snail1 is a driver of immunosuppression in melanoma. bioRxiv. 2022;[preprint] doi:10.1101/2022.11.23.517623 .

N-Fluoroalkylated Morpholinos - a New Class of Nucleoside Analogues

Authors:
Debreczeni N, Hotzi J, Bege M, Lovas M, Mező E, Bereczki I, Herczegh P, Kiss L, Borbás A
Citation:
Chemistry. 2022 Nov 27. doi: 10.1002/chem.202203248. Online ahead of print. PMID: 36437234
Epub:
Not Epub
Abstract:
The first concise and efficient synthesis of some fluorine-containing morpholino nucleosides analogs has been developed. One...
Citation Extract:
Debreczeni N, Hotzi J, Bege M, Lovas M, Mező E, Bereczki I, Herczegh P, Kiss L, Borbás A. N-Fluoroalkylated Morpholinos - a New Class of Nucleoside Analogues. Chemistry. 2022 Nov 27. doi: 10.1002/chem.202203248. Online ahead of print. PMID: 36437234 .

Use of vivo-morpholinos for gene knockdown in the postnatal shark retina

Authors:
Rodríguez-Arrizabalaga M, Hernández-Núñez I, Candal E, Barreiro-Iglesias A
Citation:
Exp Eye Res. 2022 Nov 24:109333. doi: 10.1016/j.exer.2022.109333. Online ahead of print
Epub:
Yes
Abstract:
Work in the catshark Scyliorhinus canicula has shown that the evolutionary origin of postnatal neurogenesis in vertebrates is...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Scyliorhinus canicula (catshark)
Citation Extract:
Rodríguez-Arrizabalaga M, Hernández-Núñez I, Candal E, Barreiro-Iglesias A. Use of vivo-morpholinos for gene knockdown in the postnatal shark retina. Exp Eye Res. 2022 Nov 24:109333. doi: 10.1016/j.exer.2022.109333. Online ahead of print.

Loss of Apical Sodium Bile Acid Transporter Disrupts Bile Acid Circulation and Reduces Biliary Damage in Cholangitis

Authors:
Meadows V, Marakovits C, Ekser B, Kundu D, Zhou T, Kyritsi K, Pham L, Chen L, Kennedy L, Ceci L, Wu N, Carpino G, Zhang W, Isidan A, Meyer A, Owen T, Gaudio E, Onori P, Alpini GD, Francis H
Citation:
Am J Physiol Gastrointest Liver Physiol. 2022 Nov 21. doi: 10.1152/ajpgi.00112.2022. Online ahead of print
Epub:
Yes
Abstract:
Background: Primary Sclerosing Cholangitis (PSC) is characterized by increased ductular reaction (DR), liver fibrosis, hepatic...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Meadows V, Marakovits C, Ekser B, Kundu D, Zhou T, Kyritsi K, Pham L, Chen L, Kennedy L, Ceci L, Wu N, Carpino G, Zhang W, Isidan A, Meyer A, Owen T, Gaudio E, Onori P, Alpini GD, Francis H. Loss of Apical Sodium Bile Acid Transporter Disrupts Bile Acid Circulation and Reduces Biliary Damage in Cholangitis. Am J Physiol Gastrointest Liver Physiol. 2022 Nov 21. doi: 10.1152/ajpgi.00112.2022. Online ahead of print.

Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP

Authors:
Yeager C, Carter G, Gohara DW, Yennawar NH, Enemark EJ, Arnold JJ, Cameron CE
Citation:
Nucleic Acids Res. 2022 Nov 18:gkac1054. doi: 10.1093/nar/gkac1054. Online ahead of print
Epub:
Yes
Abstract:
The enteroviral 2C protein is a therapeutic target, but the absence of a mechanistic framework for this enzyme limits our...
Citation Extract:
Yeager C, Carter G, Gohara DW, Yennawar NH, Enemark EJ, Arnold JJ, Cameron CE. Enteroviral 2C protein is an RNA-stimulated ATPase and uses a two-step mechanism for binding to RNA and ATP. Nucleic Acids Res. 2022 Nov 18:gkac1054. doi: 10.1093/nar/gkac1054. Online ahead of print.

Hnf1b renal expression directed by a distal enhancer responsive to Pax8

Authors:
Goea L, Buisson I, Bello V, Eschstruth A, Paces-Fessy M, Le Bouffant R, Chesneau A, Cereghini S, Riou JF, Umbhauer M
Citation:
Sci Rep. 2022 Nov 19;12(1):19921. doi: 10.1038/s41598-022-21171-x
Epub:
Not Epub
Abstract:
Xenopus provides a simple and efficient model system to study nephrogenesis and explore the mechanisms causing renal...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Goea L, Buisson I, Bello V, Eschstruth A, Paces-Fessy M, Le Bouffant R, Chesneau A, Cereghini S, Riou JF, Umbhauer M. Hnf1b renal expression directed by a distal enhancer responsive to Pax8. Sci Rep. 2022 Nov 19;12(1):19921. doi: 10.1038/s41598-022-21171-x.

Rassf7a promotes spinal cord regeneration and controls spindle orientation in neural progenitor cells

Authors:
Zhu P, Zheng P, Kong X, Wang S, Cao M, Zhao C
Citation:
EMBO Rep. 2022 Nov 21:e54984. doi: 10.15252/embr.202254984. Online ahead of print
Epub:
Not Epub
Abstract:
Spinal cord injury (SCI) can cause long-lasting disability in mammals due to the lack of axonal regrowth together with the...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Zhu P, Zheng P, Kong X, Wang S, Cao M, Zhao C. Rassf7a promotes spinal cord regeneration and controls spindle orientation in neural progenitor cells. EMBO Rep. 2022 Nov 21:e54984. doi: 10.15252/embr.202254984. Online ahead of print.

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