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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12570 scientific papers returned from the database with the search filters currently being used below.

MMS22L is a novel key actor of normal and pathological erythropoiesis

Authors:
Colin E, Ferrer-Vicens I, Brook D, Salma M, Andrieu-Soler C, Bayard E, Fernandes A, Brouzes C, Lefèvre C, Duval R, Dussiot M, Trovati T, Courtois G, Azouzi S, Zarhrate M, Lambilliotte A, Park S, Carpentier B, Colard M, Manceau S, Moshous D, Mayeux P, Gautier EF, Miccio A, Soulier J, Vainchenker W, Shlush L, Da Costa L, Frayne J, Soler E, Hermine O, Couronné L
Citation:
Hemasphere. 2025 Dec 23;9(12):e70264. doi: 10.1002/hem3.70264. PMID: 41446536; PMCID: PMC12723439
Epub:
Not Epub
Abstract:
The emergence of next-generation sequencing techniques has led to the genetic characterization of numerous congenital erythroid...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12723439/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Colin E, Ferrer-Vicens I, Brook D, Salma M, Andrieu-Soler C, Bayard E, Fernandes A, Brouzes C, Lefèvre C, Duval R, Dussiot M, Trovati T, Courtois G, Azouzi S, Zarhrate M, Lambilliotte A, Park S, Carpentier B, Colard M, Manceau S, Moshous D, Mayeux P, Gautier EF, Miccio A, Soulier J, Vainchenker W, Shlush L, Da Costa L, Frayne J, Soler E, Hermine O, Couronné L. MMS22L is a novel key actor of normal and pathological erythropoiesis. Hemasphere. 2025 Dec 23;9(12):e70264. doi: 10.1002/hem3.70264. PMID: 41446536; PMCID: PMC12723439.

Developmental regulation of intestinal best4+ cells

Authors:
Sur A, Segal EX, Nunneley MP, Sinclair JW, Prochaska MK, Dye LE, Wu Y, Fu L, Shi YB, Iben J, Feldman B, Farrell JA
Citation:
bioRxiv [Preprint]. 2025 Dec 19:2025.12.17.694935. doi: 10.64898/2025.12.17.694935. PMID: 41446049; PMCID: PMC12724568
Epub:
Not Epub
Abstract:
best4+/CFTR-high expressing cells are a recently described intestinal epithelial cell type potentially altered in inflammatory...
Link:
https://www.biorxiv.org/content/10.64898/2025.12.17.694935v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sur A, Segal EX, Nunneley MP, Sinclair JW, Prochaska MK, Dye LE, Wu Y, Fu L, Shi YB, Iben J, Feldman B, Farrell JA. Developmental regulation of intestinal best4+ cells. bioRxiv [Preprint]. 2025 Dec 19:2025.12.17.694935. doi: 10.64898/2025.12.17.694935. PMID: 41446049; PMCID: PMC12724568.

Pre-marking chromatin with H3K4 methylation is required for accurate zygotic genome activation and development

Authors:
Oak MS, Stock M, Janeva A, Mezes M, Hynes-Allen AM, Straub T, Forné I, Ettinger A, Hamperl S, Imhof A, van den Ameele J, Scialdone A, Hörmanseder E
Citation:
Nat Commun. 2025 Dec 19;16(1):11334. doi: 10.1038/s41467-025-67692-7. PMID: 41419741; PMCID: PMC12722762
Epub:
Not Epub
Abstract:
In vertebrate embryos, gene expression is first initiated at zygotic genome activation (ZGA). Maternally expressed...
Link:
https://www.nature.com/articles/s41467-025-67692-7
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Oak MS, Stock M, Janeva A, Mezes M, Hynes-Allen AM, Straub T, Forné I, Ettinger A, Hamperl S, Imhof A, van den Ameele J, Scialdone A, Hörmanseder E. Pre-marking chromatin with H3K4 methylation is required for accurate zygotic genome activation and development. Nat Commun. 2025 Dec 19;16(1):11334. doi: 10.1038/s41467-025-67692-7. PMID: 41419741; PMCID: PMC12722762.

Glis3 as a critical regulator of Pit1-lineages and renal functions

Authors:
Rurale G, Gentile I, Persani L, Marelli F
Citation:
J Mol Med (Berl). 2025 Dec 29;104(1):19. doi: 10.1007/s00109-025-02611-3. PMID: 41457180; PMCID: PMC12745328
Epub:
Not Epub
Abstract:
The Krüppel-like GLIS3 transcription factor acts as an effector on the sonic hedgehog (Shh) pathway, regulating several...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12745328/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rurale G, Gentile I, Persani L, Marelli F. Glis3 as a critical regulator of Pit1-lineages and renal functions. J Mol Med (Berl). 2025 Dec 29;104(1):19. doi: 10.1007/s00109-025-02611-3. PMID: 41457180; PMCID: PMC12745328.

Targeted antisense oligonucleotide treatment rescues developmental alterations in spinal muscular atrophy organoids

Authors:
Faravelli I, Rinchetti P, Tambalo M, Simutin I, Mapelli L, Mancinelli S, Miotto M, Rizzuti M, D'Angelo A, Cordiglieri C, Forotti G, Peano C, Kunderfranco P, Calandriello L, Comi GP, Paraboschi E, Pali E, Beatrice F, D'Angelo E, Przedborski S, Nizzardo M, Lodato S, Corti S
Citation:
Nat Commun. 2025 Dec 21. doi: 10.1038/s41467-025-67725-1. Epub ahead of print. PMID: 41423447
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is a severe neurological disease caused by mutations in the SMN1 gene, characterized by early...
Link:
https://www.nature.com/articles/s41467-025-67725-1
Delivery Method:
R6 peptide-linked
Organism or Cell Type:
SMA type 1 patient-derived spinal cord and cerebral organoids
Citation Extract:
Faravelli I, Rinchetti P, Tambalo M, Simutin I, Mapelli L, Mancinelli S, Miotto M, Rizzuti M, D'Angelo A, Cordiglieri C, Forotti G, Peano C, Kunderfranco P, Calandriello L, Comi GP, Paraboschi E, Pali E, Beatrice F, D'Angelo E, Przedborski S, Nizzardo M, Lodato S, Corti S. Targeted antisense oligonucleotide treatment rescues developmental alterations in spinal muscular atrophy organoids. Nat Commun. 2025 Dec 21. doi: 10.1038/s41467-025-67725-1. Epub ahead of print. PMID: 41423447.

Candida spp. suppress neutrophil reactive nitrogen species to evade killing

Authors:
Burgess TB, Hammond FR, Szkuta PT, Lewis A, Christou S, Bowden KA, Bicanic T, Prince LR, Ayscough KR, Partridge DG, Johnston SA, Condliffe AM, Elks PM
Citation:
bioRxiv [preprint] 2023.11.02.565128; doi: https://doi.org/10.1101/2023.11.02.565128
Epub:
Not Epub
Abstract:
Candida albicans is a human commensal that can cause life-threatening invasive infection in immunocompromised individuals....
Link:
https://www.biorxiv.org/content/10.1101/2023.11.02.565128v2.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Burgess TB, Hammond FR, Szkuta PT, Lewis A, Christou S, Bowden KA, Bicanic T, Prince LR, Ayscough KR, Partridge DG, Johnston SA, Condliffe AM, Elks PM. Candida spp. suppress neutrophil reactive nitrogen species to evade killing. bioRxiv [preprint] 2023.11.02.565128; doi: https://doi.org/10.1101/2023.11.02.565128.

Behavioral improvement in dystrophic mdx23 mouse following repeated antisense oligonucleotides injections

Authors:
Aghaeipour A, Mitsogiannis M, Fergus C, Tetorou K, Gileadi T, Stojek E, Talavera S, Singh S, Siddle M, Prendeville J, Sokolowska E, Kelly V, Morgan J, Montanaro F, Muntoni F
Citation:
Mol Ther Nucleic Acids. 2025 Oct 24;36(4):102750. doi: 10.1016/j.omtn.2025.102750. PMID: 41467120; PMCID: PMC12744854
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder caused by mutations in the DMD gene that disrupt the...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12744854/
Delivery Method:
intracisternal magna (i.c.m.) and intraperitoneal (i.p.) injection
Organism or Cell Type:
mdx23 mice
Citation Extract:
Aghaeipour A, Mitsogiannis M, Fergus C, Tetorou K, Gileadi T, Stojek E, Talavera S, Singh S, Siddle M, Prendeville J, Sokolowska E, Kelly V, Morgan J, Montanaro F, Muntoni F. Behavioral improvement in dystrophic mdx23 mouse following repeated antisense oligonucleotides injections. Mol Ther Nucleic Acids. 2025 Oct 24;36(4):102750. doi: 10.1016/j.omtn.2025.102750. PMID: 41467120; PMCID: PMC12744854.

Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying supporting lineage differentiation

Authors:
Chen YY, Rodriguez K, Alexander AK, Xu X, Papas B, Estermann MA, Yao HH
Citation:
Sci Adv. 2026 Jan 2;12(1):eaea7403. doi: 10.1126/sciadv.aea7403. Epub 2026 Jan 2. PMID: 41481707; PMCID: PMC12758517
Epub:
Not Epub
Abstract:
Sex determination of mammalian gonads hinges upon sex-specific differentiation of gonadal supporting cells: Sertoli cells in...
Link:
https://www.science.org/doi/10.1126/sciadv.aea7403
Delivery Method:
Vivo-Morpholino culture
Organism or Cell Type:
C57BL/6J mouse gonads
Citation Extract:
Chen YY, Rodriguez K, Alexander AK, Xu X, Papas B, Estermann MA, Yao HH. Single-nucleus multiomics of murine gonads reveals transcriptional regulatory network underlying supporting lineage differentiation. Sci Adv. 2026 Jan 2;12(1):eaea7403. doi: 10.1126/sciadv.aea7403. Epub 2026 Jan 2. PMID: 41481707; PMCID: PMC12758517.

Timing matters: exon skipping therapy is most effective when initiated early in a mouse model of Duchenne muscular dystrophy

Authors:
Stenler S, Huang J, van Westering TLE, Coenen-Stass AML, Krjutškov K, Andaloussi SEL, Wood MJA, Roberts TC
Citation:
bioRxiv [preprint] 2025.12.23.696144; doi: https://doi.org/10.64898/2025.12.23.696144
Epub:
Not Epub
Abstract:
Exon skipping is a leading therapeutic approach for Duchenne muscular dystrophy (DMD), a progressive muscle wasting disorder...
Link:
https://www.biorxiv.org/content/10.64898/2025.12.23.696144v1.full
Delivery Method:
Pip6a peptide-linked; intravenous (i.v.)
Organism or Cell Type:
mdx mice
Citation Extract:
Stenler S, Huang J, van Westering TLE, Coenen-Stass AML, Krjutškov K, Andaloussi SEL, Wood MJA, Roberts TC. Timing matters: exon skipping therapy is most effective when initiated early in a mouse model of Duchenne muscular dystrophy. bioRxiv [preprint] 2025.12.23.696144; doi: https://doi.org/10.64898/2025.12.23.696144.

Giardiavirus rewires host translation and glycolytic metabolism to support its replication in Giardia duodenalis

Authors:
Li L, Cao L, Zhong C, Zhang N, Li X, Wang X, Guo Y, Yu Y, Li J, Zhang X, Le Y, Yuan J, Gong P
Citation:
Virulence. 2026 Dec;17(1):2605746. doi: 10.1080/21505594.2025.2605746. Epub 2025 Dec 24. PMID: 41445118; PMCID: PMC12758212
Epub:
Not Epub
Abstract:
Giardia duodenalis is an intestinal protozoan parasite responsible for giardiasis, a disease primarily characterized by...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12758212/
Delivery Method:
electroporation
Organism or Cell Type:
Giardia duodenalis
Citation Extract:
Li L, Cao L, Zhong C, Zhang N, Li X, Wang X, Guo Y, Yu Y, Li J, Zhang X, Le Y, Yuan J, Gong P. Giardiavirus rewires host translation and glycolytic metabolism to support its replication in Giardia duodenalis. Virulence. 2026 Dec;17(1):2605746. doi: 10.1080/21505594.2025.2605746. Epub 2025 Dec 24. PMID: 41445118; PMCID: PMC12758212.

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