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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10798 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Zebrafish Minichromosome Maintenance Protein 5 Gene Regulates the Development and Migration of Facial Motor Neurons via Fibroblast Growth Factor Signaling

Authors:
Wu Y, Huang S, Zhao H, Cao K, Gan J, Yang C, Xu Z, Li S, Su B
Citation:
Dev Neurosci. 2021;[Epub} doi:10.1159/000514852
Epub:
Not Epub
Abstract:
Minichromosome maintenance protein 5 (MCM5), a member of the microchromosomal maintenance protein family, plays an important...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu Y, Huang S, Zhao H, Cao K, Gan J, Yang C, Xu Z, Li S, Su B. Zebrafish Minichromosome Maintenance Protein 5 Gene Regulates the Development and Migration of Facial Motor Neurons via Fibroblast Growth Factor Signaling. Dev Neurosci. 2021;[Epub} doi:10.1159/000514852.

A single-cell-resolution fate map of endoderm reveals demarcation of pancreatic progenitors by cell cycle

Authors:
Yang Y, Wang H, He J, Shi W, Jiang Z, Gao L, Jiang Y, Ni R, Yang Q, Luo L
Citation:
Proc Nat Acad Sci USA. 2021;118(25):e2025793118. doi:10.1073/pnas.2025793118
Epub:
Not Epub
Abstract:
A progenitor cell could generate a certain type or multiple types of descendant cells during embryonic development. To make all...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang Y, Wang H, He J, Shi W, Jiang Z, Gao L, Jiang Y, Ni R, Yang Q, Luo L. A single-cell-resolution fate map of endoderm reveals demarcation of pancreatic progenitors by cell cycle. Proc Nat Acad Sci USA. 2021;118(25):e2025793118. doi:10.1073/pnas.2025793118 .

Echinoderm Microtubule Associated Protein Like 1 Is Indispensable for Oocyte Spindle Assembly and Meiotic Progression in Mice

Authors:
Yin H, Zhang T, Wang H, Hu X, Hou X, Fang X, Yin Y, Li H, Shi L, Su YQ
Citation:
Front Cell Dev Biol. 2021 May 28;9:687522. doi:10.3389/fcell.2021.687522. eCollection 2021
Epub:
Not Epub
Abstract:
Completion of the first meiosis is an essential prerequisite for producing a functionally normal egg for fertilization and...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Yin H, Zhang T, Wang H, Hu X, Hou X, Fang X, Yin Y, Li H, Shi L, Su YQ. Echinoderm Microtubule Associated Protein Like 1 Is Indispensable for Oocyte Spindle Assembly and Meiotic Progression in Mice. Front Cell Dev Biol. 2021 May 28;9:687522. doi:10.3389/fcell.2021.687522. eCollection 2021.

Chapter Six - Emerging RNA Suppression Technologies to Protect Citrus Trees From Citrus Greening Disease Bacteria

Authors:
Hunter WB, Sinisterra-Hunter SH
Citation:
Adv In Insect Physiol. 2018;55:163-197. doi:10.1016/bs.aiip.2018.08.001
Epub:
Not Epub
Abstract:
Research on the development of RNA-suppressing technologies, which include RNA interference, (RNAi), and the application of RNA...
Delivery Method:
peptide-linked
Organism or Cell Type:
Candidatus Liberibacter asiaticus
Citation Extract:
Hunter WB, Sinisterra-Hunter SH. Chapter Six - Emerging RNA Suppression Technologies to Protect Citrus Trees From Citrus Greening Disease Bacteria. Adv In Insect Physiol. 2018;55:163-197. doi:10.1016/bs.aiip.2018.08.001.

Neutral Surfactant Enhanced Exon-skipping of Morpholino Oligonucleotides in vitro and in mdx Mice

Authors:
Wu B, Drains M, Lu P, Lu Q, Wang M
Citation:
J Nanomed Nanotechnol. 2020;11(6):553. doi:10.35248/2157-7439.20.11.553
Epub:
Not Epub
Abstract:
Antisense oligomers induced exon-skipping has been promising therapy for Duchenne muscular dystrophy in preclinical and...
Delivery Method:
Endo-Porter (culture), local injection (mice)
Organism or Cell Type:
cell culture: C2C12E50 myoblasts and C2C12E23 differentiated cells expressing human dystrophin exon 50 sequence (hDyE50), mouse dystrophin exon 23 sequence (mDyE23) in the GFP coding sequence, respectively; mdx mice
Citation Extract:
Wu B, Drains M, Lu P, Lu Q, Wang M. Neutral Surfactant Enhanced Exon-skipping of Morpholino Oligonucleotides in vitro and in mdx Mice. J Nanomed Nanotechnol. 2020;11(6):553. doi:10.35248/2157-7439.20.11.553.

Sobp modulates Six1 transcriptional activation and is required during craniofacial development

Authors:
Tavares ALP, Jourdeuil K, Neilson KM, Majumdar HD, Moody SA
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.05.438472
Epub:
Not Epub
Abstract:
Single nucleotide mutations in SIX1 are causative in some individuals diagnosed with branchio-otic/branchio-oto-renal (BOR)...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Tavares ALP, Jourdeuil K, Neilson KM, Majumdar HD, Moody SA. Sobp modulates Six1 transcriptional activation and is required during craniofacial development. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.05.438472 .

Ciliogenesis and autophagy are coordinately regulated by EphA2 in the cornea to maintain proper epithelial architecture

Authors:
Kaplan N, Wang S, Wang J, Yang W, Ventrella R, Majekodunmi A, Perez White BE, Getsios S, Mitchell BJ, Peng H, Lavker RM
Citation:
Ocul Surf. 2021;[Epub ahead of print] doi:10.1016/j.jtos.2021.06.006
Epub:
Not Epub
Abstract:
Purpose To understand the relationship between ciliogenesis and autophagy in the corneal epithelium. Methods siRNAs for...
Organism or Cell Type:
Xenopus
Citation Extract:
Kaplan N, Wang S, Wang J, Yang W, Ventrella R, Majekodunmi A, Perez White BE, Getsios S, Mitchell BJ, Peng H, Lavker RM. Ciliogenesis and autophagy are coordinately regulated by EphA2 in the cornea to maintain proper epithelial architecture. Ocul Surf. 2021;[Epub ahead of print] doi:10.1016/j.jtos.2021.06.006.

Survival motor neuron deficiency slows myoblast fusion through reduced myomaker and myomixer expression

Authors:
McCormack NM, Villalón E, Viollet C, Soltis AR, Dalgard CL, Lorson CL, Burnett BG
Citation:
J. Cachexia Sarcopenia Muscle. 2021;[Epub] doi:10.1002/jcsm.12740
Epub:
Yes
Abstract:
Background Spinal muscular atrophy is an inherited neurodegenerative disease caused by insufficient levels of the survival...
Delivery Method:
intracerebroventricular (icv) injection
Organism or Cell Type:
mice
Citation Extract:
McCormack NM, Villalón E, Viollet C, Soltis AR, Dalgard CL, Lorson CL, Burnett BG. Survival motor neuron deficiency slows myoblast fusion through reduced myomaker and myomixer expression. J. Cachexia Sarcopenia Muscle. 2021;[Epub] doi:10.1002/jcsm.12740.

Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division

Authors:
Zhao X, Garcia JQ, Tong K, Chen X, Yang B, Li Q, Dai Z, Shi X, Seiple IB, Huang B, Guo S
Citation:
Sci Adv. 2021;7(24):eabg1244. doi:10.1126/sciadv.abg1244
Epub:
Not Epub
Abstract:
In the developing embryos, the cortical polarity regulator Par-3 is critical for establishing Notch signaling asymmetry between...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhao X, Garcia JQ, Tong K, Chen X, Yang B, Li Q, Dai Z, Shi X, Seiple IB, Huang B, Guo S. Polarized endosome dynamics engage cytoplasmic Par-3 that recruits dynein during asymmetric cell division. Sci Adv. 2021;7(24):eabg1244. doi:10.1126/sciadv.abg1244.

Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung

Authors:
Dang Y, van Heusden C, Nickerson V, Chung F, Wang Y, Quinney NL, Gentzsch M, Randell SH, Moulton HM, Kole R, Ni A, Juliano RL, Kreda SM
Citation:
Nucleic Acids Res. 2021 Jun 9:gkab488. doi: 10.1093/nar/gkab488. Online ahead of print
Epub:
Yes
Abstract:
Pulmonary diseases offer many targets for oligonucleotide therapeutics. However, effective delivery of oligonucleotides to the...
Delivery Method:
peptide-linked plus endosome escape reagent (OEC)
Organism or Cell Type:
cell culture: HeLa EGFP654, Human Bronchial Epithelial, UNCCF8T, EGFP654 Mouse Tracheal Epithelial, mouse
Citation Extract:
Dang Y, van Heusden C, Nickerson V, Chung F, Wang Y, Quinney NL, Gentzsch M, Randell SH, Moulton HM, Kole R, Ni A, Juliano RL, Kreda SM. Enhanced delivery of peptide-morpholino oligonucleotides with a small molecule to correct splicing defects in the lung. Nucleic Acids Res. 2021 Jun 9:gkab488. doi: 10.1093/nar/gkab488. Online ahead of print.

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