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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9829 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway

Authors:
Sun X, Zhou Y, Zhang R, Wang Z, Xu M, Zhang D, Huang J, Luo F, Li F, Ni Z, Zhou S, Chen H, Chen S, Chen L, Du X, Chen B, Huang H, Liu P, Yin L, Qiu J, Chen D, Deng C, Xie Y, Luo L, Chen L
Citation:
Nat Comm. 2020;11(1):479 doi:10.1038/s41467-019-14169-z
Abstract:
Congenital scoliosis (CS) is a complex genetic disorder characterized by vertebral malformations. The precise etiology of CS is...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sun X, Zhou Y, Zhang R, Wang Z, Xu M, Zhang D, Huang J, Luo F, Li F, Ni Z, Zhou S, Chen H, Chen S, Chen L, Du X, Chen B, Huang H, Liu P, Yin L, Qiu J, Chen D, Deng C, Xie Y, Luo L, Chen L. Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway. Nat Comm. 2020;11(1):479 doi:10.1038/s41467-019-14169-z.

Hmx3a does not require its homeodomain for its essential functions in spinal cord, ear and lateral line development

Authors:
England SJ, Cerda GA, Kowalchuk AM, Sorice T, Grieb GM, Lewis KE
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.23.917468
Abstract:
Homeodomain-containing transcription factors have crucial functions in most aspects of cellular function and embryonic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
England SJ, Cerda GA, Kowalchuk AM, Sorice T, Grieb GM, Lewis KE. Hmx3a does not require its homeodomain for its essential functions in spinal cord, ear and lateral line development. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.23.917468.

A Novel Recessive TNNT1 Congenital Core-Rod Myopathy in French Canadians

Authors:
Pellerin D, Aykanat A, Ellezam B, Troiano EC, Karamchandani J, Dicaire MJ, Petitclerc M, Robertson R, Allard-Chamard X, Brunet D, Konersman CG, Mathieu J, Warman Chardon J, Gupta VA, Beggs AH, Brais B, Chrestian N
Citation:
Ann Neurol. 2020 Jan 22. doi: 10.1002/ana.25685. [Epub ahead of print]
Abstract:
OBJECTIVE: Recessive null variants of the slow skeletal muscle troponin T1 (TNNT1) gene are a rare cause of nemaline myopathy...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pellerin D, Aykanat A, Ellezam B, Troiano EC, Karamchandani J, Dicaire MJ, Petitclerc M, Robertson R, Allard-Chamard X, Brunet D, Konersman CG, Mathieu J, Warman Chardon J, Gupta VA, Beggs AH, Brais B, Chrestian N. A Novel Recessive TNNT1 Congenital Core-Rod Myopathy in French Canadians. Ann Neurol. 2020 Jan 22. doi: 10.1002/ana.25685. [Epub ahead of print].

Stepwise polarisation of developing bilayered epidermis is mediated by aPKC and E-cadherin in zebrafish

Authors:
Arora P, Dongre S, Raman R, Sonawane M
Citation:
eLife. 2020;9:e49064. doi:10.7554/eLife.49064
Abstract:
The epidermis, a multilayered epithelium, surrounds and protects the vertebrate body. It develops from a bilayered epithelium...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Arora P, Dongre S, Raman R, Sonawane M. Stepwise polarisation of developing bilayered epidermis is mediated by aPKC and E-cadherin in zebrafish. eLife. 2020;9:e49064. doi:10.7554/eLife.49064.

The gap junction protein Connexin 43 controls multiple aspects of cranial neural crest cell development

Authors:
Jourdeuil K, Taneyhill LA
Citation:
J Cell Sci. 2020;[Epub ahead of print] doi:10.1242/jcs.235440
Abstract:
Gap junctions are intercellular channels between cells that facilitate cell-cell communication. Connexin 43 (Cx43), the...
Organism or Cell Type:
Gallus gallus (chick) cultures and in vivo
Citation Extract:
Jourdeuil K, Taneyhill LA. The gap junction protein Connexin 43 controls multiple aspects of cranial neural crest cell development. J Cell Sci. 2020;[Epub ahead of print] doi:10.1242/jcs.235440.

Coupling of dynamic microtubules to F-actin by Fmn2 regulates chemotaxis of neuronal growth cones

Authors:
Kundu T, Dutta P, Nagar D, Maiti S, Ghose A
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.18.911131
Abstract:
Dynamic co-regulation of the actin and microtubule subsystems enables the highly precise and adaptive remodeling of the...
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: primary Gallus gallus (chick) neurons
Citation Extract:
Kundu T, Dutta P, Nagar D, Maiti S, Ghose A. Coupling of dynamic microtubules to F-actin by Fmn2 regulates chemotaxis of neuronal growth cones. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.18.911131.

Kctd15 regulates nephron segment development by repressing Tfap2a activity

Authors:
Chambers BE, Clark EG, Gatz AE, Wingert RA
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.17.910760
Abstract:
A functional vertebrate kidney relies on structural units called nephrons, which are epithelial tubules that contain a sequence...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chambers BE, Clark EG, Gatz AE, Wingert RA. Kctd15 regulates nephron segment development by repressing Tfap2a activity. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.17.910760 .

A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

Authors:
Kainov YA, Makeyev EV
Citation:
Nat Commun. 2020 Jan 17;11(1):361. doi: 10.1038/s41467-019-14204-z
Abstract:
Eukaryotic gene expression relies on extensive crosstalk between transcription and RNA processing. Changes in this composite...
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: A2lox mouse ESCs (embryonic stem cells)
Citation Extract:
Kainov YA, Makeyev EV. A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells. Nat Commun. 2020 Jan 17;11(1):361. doi: 10.1038/s41467-019-14204-z.

ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin

Authors:
Tanaka I, Chakraborty A, Saulnier O, Benoit-Pilven C, Vacher S, Labiod D, Lam EWF, Bièche I, Delattre O, Pouzoulet F, Auboeuf D, Vagner S, Dutertre M
Citation:
Nucleic Acids Res. 2020 Jan 16. pii: gkz1213. doi: 10.1093/nar/gkz1213. [Epub ahead of print]
Abstract:
Besides analyses of specific alternative splicing (AS) variants, little is known about AS regulatory pathways and programs...
Delivery Method:
Endo-Porter PEG; Vivo-Morpholino
Organism or Cell Type:
cell culture: MCF7-DoxoR; female Swiss Nu/nu mice intratumoral
Citation Extract:
Tanaka I, Chakraborty A, Saulnier O, Benoit-Pilven C, Vacher S, Labiod D, Lam EWF, Bièche I, Delattre O, Pouzoulet F, Auboeuf D, Vagner S, Dutertre M. ZRANB2 and SYF2-mediated splicing programs converging on ECT2 are involved in breast cancer cell resistance to doxorubicin. Nucleic Acids Res. 2020 Jan 16. pii: gkz1213. doi: 10.1093/nar/gkz1213. [Epub ahead of print].

Microglial activation increases cocaine self-administration following adolescent nicotine exposure

Authors:
Linker KE, Elabd MG, Tawadrous P, Cano M, Green KN, Wood MA, Leslie FM
Citation:
Nat Commun. 2020 Jan 16;11(1):306. doi: 10.1038/s41467-019-14173-3
Abstract:
With the rise of e-cigarette use, teen nicotine exposure is becoming more widespread. Findings from clinical and preclinical...
Delivery Method:
intracranial Vivo-Morpholino
Organism or Cell Type:
Sprague-Dawley rat
Citation Extract:
Linker KE, Elabd MG, Tawadrous P, Cano M, Green KN, Wood MA, Leslie FM. Microglial activation increases cocaine self-administration following adolescent nicotine exposure. Nat Commun. 2020 Jan 16;11(1):306. doi: 10.1038/s41467-019-14173-3.

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