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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11304 scientific papers returned from the database with the search filters currently being used below.

Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation

Authors:
You B, Pan S, Gu M, Zhang K, Xia T, Zhang S, Chen W, Xie H, Fan Y, Yao H, Cheng T, Zhang P, Liu D, You Y
Citation:
J Extracell Vesicles. 2022 May;11(5):e12221. doi: 10.1002/jev2.12221
Epub:
Not Epub
Abstract:
Tumour-associated angiogenesis plays a critical role in metastasis, the main cause of malignancy-related death. Extracellular...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
You B, Pan S, Gu M, Zhang K, Xia T, Zhang S, Chen W, Xie H, Fan Y, Yao H, Cheng T, Zhang P, Liu D, You Y. Extracellular vesicles rich in HAX1 promote angiogenesis by modulating ITGB6 translation. J Extracell Vesicles. 2022 May;11(5):e12221. doi: 10.1002/jev2.12221.

RanBP1 plays an essential role in directed migration of neural crest cells during development

Authors:
Barriga EH, Alasaadi DN, Mencarelli C, Mayor R, Pichaud F
Citation:
bioRxiv. 2022:490747. doi:10.1101/2022.05.05.490747
Epub:
Not Epub
Abstract:
Collective cell migration is essential for embryonic development, tissue regeneration and repair, and has been implicated in...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Barriga EH, Alasaadi DN, Mencarelli C, Mayor R, Pichaud F. RanBP1 plays an essential role in directed migration of neural crest cells during development. bioRxiv. 2022:490747. doi:10.1101/2022.05.05.490747 .

Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis

Authors:
Heilig AK, Nakamura R, Shimada A, Hashimoto Y, Nakamura Y, Wittbrodt J, Takeda H, Kawanishi T
Citation:
eLife. 2022;11:e71845. doi:10.7554/eLife.71845
Epub:
Not Epub
Abstract:
The dorsal axial muscles, or epaxial muscles, are a fundamental structure covering the spinal cord and vertebrae, as well as...
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Heilig AK, Nakamura R, Shimada A, Hashimoto Y, Nakamura Y, Wittbrodt J, Takeda H, Kawanishi T. Wnt11 acts on dermomyotome cells to guide epaxial myotome morphogenesis. eLife. 2022;11:e71845. doi:10.7554/eLife.71845.

Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways

Authors:
Lu Y, Tang D, Zheng Z, Wang X, Zuo N, Yan R, Wu C, Ma J, Wang C, Xu H, He Y, Liu D, Liu S
Citation:
Front Mol Neurosci. 2022;15:844668. doi:10.3389/fnmol.2022.844668
Epub:
Not Epub
Abstract:
Cingulin, a cytoplasmic element of tight junctions (TJs), is involved in maintenance of the integrity of epithelial and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lu Y, Tang D, Zheng Z, Wang X, Zuo N, Yan R, Wu C, Ma J, Wang C, Xu H, He Y, Liu D, Liu S. Cingulin b Is Required for Zebrafish Lateral Line Development Through Regulation of Mitogen-Activated Protein Kinase and Cellular Senescence Signaling Pathways. Front Mol Neurosci. 2022;15:844668. doi:10.3389/fnmol.2022.844668.

Role of suppressing GLT-1 and xCT in ceftriaxone-induced attenuation of relapse-like alcohol drinking in alcohol-preferring rats

Authors:
Das SC, Althobaiti YS, Hammad AM, Alasmari F, Sari Y
Citation:
Addict Biol. 2022;[Epub] doi:10.1111/adb.13178
Epub:
Yes
Abstract:
Alcohol dependence results in long-lasting neuroadaptive changes in meso-corticolimbic system, especially in the nucleus...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
rat
Citation Extract:
Das SC, Althobaiti YS, Hammad AM, Alasmari F, Sari Y. Role of suppressing GLT-1 and xCT in ceftriaxone-induced attenuation of relapse-like alcohol drinking in alcohol-preferring rats. Addict Biol. 2022;[Epub] doi:10.1111/adb.13178.

Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells

Authors:
Brunsdon H, Brombin A, Peterson S, Postlethwait JH, Patton EE
Citation:
Development. 2022 Apr 29:dev.200277. doi: 10.1242/dev.200277. Online ahead of print
Epub:
Not Epub
Abstract:
Melanocyte stem cells (McSCs) in zebrafish serve as an on-demand source of melanocytes during growth and regeneration, but...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Brunsdon H, Brombin A, Peterson S, Postlethwait JH, Patton EE. Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells. Development. 2022 Apr 29:dev.200277. doi: 10.1242/dev.200277. Online ahead of print.

Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration

Authors:
Porpiglia E, Mai T, Kraft P, Holbrook CA, de Morree A, Gonzalez VD, Hilgendorf K, Fresard L, Trejo A, Bhimaraju S, Jackson PK, Fantl WJ, Blau HM
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.04.29.489435
Epub:
Not Epub
Abstract:
In aging, skeletal muscle strength and regenerative capacity declines due, in part, to functional impairment of muscle stem...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: muscle stem cells
Citation Extract:
Porpiglia E, Mai T, Kraft P, Holbrook CA, de Morree A, Gonzalez VD, Hilgendorf K, Fresard L, Trejo A, Bhimaraju S, Jackson PK, Fantl WJ, Blau HM. Elevated CD47 is a hallmark of dysfunctional aged muscle stem cells that can be targeted to augment regeneration. bioRxiv. 2022;[preprint] doi:10.1101/2022.04.29.489435.

Tollip-deficient zebrafish display no abnormalities in development, organ morphology or gene expression in response to lipopolysaccharide

Authors:
Wolińska-Nizioł L, Romaniuk K, Wojciechowska K, Surga K, Kamaszewski M, Szudrowicz H, Miączyńska M
Citation:
FEBS Open Bio. 2022 May 3. doi: 10.1002/2211-5463.13423. Online ahead of print
Epub:
Not Epub
Abstract:
Tollip is a multifunctional adaptor protein implicated in innate immunity, lysosomal trafficking/autophagy of protein...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wolińska-Nizioł L, Romaniuk K, Wojciechowska K, Surga K, Kamaszewski M, Szudrowicz H, Miączyńska M. Tollip-deficient zebrafish display no abnormalities in development, organ morphology or gene expression in response to lipopolysaccharide. FEBS Open Bio. 2022 May 3. doi: 10.1002/2211-5463.13423. Online ahead of print.

Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish

Authors:
Shibata T, Kawana H, Nishino Y, Ito Y, Sato H, Onishi H, Kano K, Inoue A, Taketomi Y, Murakami M, Kofuji S, Nishina H, Miyazawa A, Kono N, Aoki J
Citation:
Sci Rep. 2022 May 4;12(1):7312. doi: 10.1038/s41598-022-11002-4
Epub:
Not Epub
Abstract:
Phospholipids in the membrane consist of diverse pairs of fatty acids bound to a glycerol backbone. The biological significance...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shibata T, Kawana H, Nishino Y, Ito Y, Sato H, Onishi H, Kano K, Inoue A, Taketomi Y, Murakami M, Kofuji S, Nishina H, Miyazawa A, Kono N, Aoki J. Abnormal male reproduction and embryonic development induced by downregulation of a phospholipid fatty acid-introducing enzyme Lpgat1 in zebrafish. Sci Rep. 2022 May 4;12(1):7312. doi: 10.1038/s41598-022-11002-4.

Guanidinium-Functionalized Flexible Azaproline Transporter for Efficient Intracellular Delivery of Proapoptotic Peptide and PDL1 Antisense Morpholino Oligo in Human Carcinoma Cells In Vitro

Authors:
Gupta A, Gupta S, Das U, Sinha S
Citation:
Bioconjugate Chem. 2022;[Epub] doi:10.1021/acs.bioconjchem.2c00129
Epub:
Not Epub
Abstract:
Cell-penetrating peptides (CPPs) are structurally diverse sophisticated tools endowed with high arginine content,...
Delivery Method:
azaproline-tetraguanidinium transporter "FAT"
Organism or Cell Type:
cell culture: CHO cells, human carcinoma cells
Citation Extract:
Gupta A, Gupta S, Das U, Sinha S. Guanidinium-Functionalized Flexible Azaproline Transporter for Efficient Intracellular Delivery of Proapoptotic Peptide and PDL1 Antisense Morpholino Oligo in Human Carcinoma Cells In Vitro. Bioconjugate Chem. 2022;[Epub] doi:10.1021/acs.bioconjchem.2c00129.

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