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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12338 scientific papers returned from the database with the search filters currently being used below.
There are 12338 scientific papers returned from the database with the search filters currently being used below.
Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish
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Citation:
Proc Natl Acad Sci U S A. 2025 Mar 25;122(12):e2420534122. doi: 10.1073/pnas.2420534122. Epub 2025 Mar 20. PMID: 40112113 Epub:
Not Epub Abstract:
During fetal stage, hematopoietic stem and progenitor cells (HSPCs) undergo rapid proliferation with a tight control of genomic... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Wang X, Liu M, Zhang Y, Ma D, Wang L, Liu F. Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish. Proc Natl Acad Sci U S A. 2025 Mar 25;122(12):e2420534122. doi: 10.1073/pnas.2420534122. Epub 2025 Mar 20. PMID: 40112113. |
Elevated body temperature exacerbates arrhythmia and seizure-like activity in a zebrafish model of Timothy syndrome
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Citation:
bioRxiv [preprint] 2025.03.11.642683; doi: https://doi.org/10.1101/2025.03.11.642683 Epub:
Not Epub Abstract:
Timothy syndrome (TS) is a multisystem disorder with autistic-like features, seizures and arrhythmia as the main symptoms. Most... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Semenova SA, Sams AM, Nammi D, Menold M, Margolin G, Sinclair JL, Robertson KA, Larkin K, Kelly S, Golden A, Feldman B, Burgess HA. Elevated body temperature exacerbates arrhythmia and seizure-like activity in a zebrafish model of Timothy syndrome. bioRxiv [preprint] 2025.03.11.642683; doi: https://doi.org/10.1101/2025.03.11.642683. |
A Robust Strategy for Introducing Amino-Modifiers in Nucleic Acids: Enabling Novel Amino Tandem Oligonucleotide Synthesis in DNA and RNA
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Citation:
Chemistry. 2025 Mar 24:e202500448. doi: 10.1002/chem.202500448. Epub ahead of print. PMID: 40127302 Epub:
Not Epub Abstract:
Amino-modifiers are pivotal chemical modifications in nucleic acid scaffolds, serving applications ranging from (bio)... Delivery Method:
None Organism or Cell Type:
None Citation Extract: Saraya JS, Horton NG, Sammons SR, O'Flaherty DK. A Robust Strategy for Introducing Amino-Modifiers in Nucleic Acids: Enabling Novel Amino Tandem Oligonucleotide Synthesis in DNA and RNA. Chemistry. 2025 Mar 24:e202500448. doi: 10.1002/chem.202500448. Epub ahead of print. PMID: 40127302. |
Catalytic activity of KMT5B promotes cilia tuft formation without affecting chromatin accessibility of ciliary genes
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Citation:
bioRxiv 2025.03.18.644017; doi: https://doi.org/10.1101/2025.03.18.644017 Epub:
Not Epub Abstract:
Multiciliated cells are a specialized cell type found in the brain, reproductive tract and respiratory tract of mammals.... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Tait J, Marthen C, Hoelscher B, Straub T, Rupp R. Catalytic activity of KMT5B promotes cilia tuft formation without affecting chromatin accessibility of ciliary genes. bioRxiv 2025.03.18.644017; doi: https://doi.org/10.1101/2025.03.18.644017. |
Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation
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Citation:
J Am Coll Cardiol Basic Trans Science. null2025, 0 (0). https://doi.org/10.1016/j.jacbts.2024.12.015 Epub:
Not Epub Abstract:
Micro-dystrophin replacement gene therapy is currently under clinical trials in Duchenne muscular dystrophy (DMD) patients.... Delivery Method:
peptide-linked combined therapy with AAV-U7; retro-orbital & intravenous (i.v.) Organism or Cell Type:
mice: C57BL/6J, dystrophin−/−; utrophin−/− dKO, mdx (utrophin−/−) Citation Extract: Forand A, Moog S, Mougenot N, Lemaitre M, Sevoz-Couche C, Guesmia Z, Virtanen L, Giordani L, Muchir A, Pietri-Rouxel F. Long-Term Dystrophin Replacement Therapy in Duchenne Muscular Dystrophy Causes Cardiac Inflammation. J Am Coll Cardiol Basic Trans Science. null2025, 0 (0). https://doi.org/10.1016/j.jacbts.2024.12.015. |
A nucleus-encoded dynamin-like protein controls endosymbiont division in the trypanosomatid Angomonas deanei
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Citation:
Sci Adv. 2025 Mar 21;11(12):eadp8518. doi: 10.1126/sciadv.adp8518. Epub 2025 Mar 19. PMID: 40106558 Epub:
Not Epub Abstract:
Angomonas deanei is a trypanosomatid of the Strigomonadinae. All members of this subfamily contain a single β-proteobacterial... Delivery Method:
electroporation Organism or Cell Type:
Angomonas deanei (trypanosoma) Citation Extract: Maurya AK, Kröninger L, Ehret G, Bäumers M, Marson M, Scheu S, Nowack ECM. A nucleus-encoded dynamin-like protein controls endosymbiont division in the trypanosomatid Angomonas deanei. Sci Adv. 2025 Mar 21;11(12):eadp8518. doi: 10.1126/sciadv.adp8518. Epub 2025 Mar 19. PMID: 40106558. |
Modeling epilepsy by loss-of-function of the CUG-binding protein Elav-like family member 2 in zebrafish with multi-omics analysis
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Citation:
Chin Med J (Engl). 2025 Mar 11. doi: 10.1097/CM9.0000000000003398. Epub ahead of print. PMID: 40066778 Epub:
Not Epub Abstract:
Background: The CUG-binding protein Elav-like family member 2 (CELF2) gene has been linked to the pathogenesis of epilepsy, but... Link:
Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Wang X, Zhang J, Rao X, Liu Y, Lin Z, Chen F, Luo R, Sun H, Gan J. Modeling epilepsy by loss-of-function of the CUG-binding protein Elav-like family member 2 in zebrafish with multi-omics analysis. Chin Med J (Engl). 2025 Mar 11. doi: 10.1097/CM9.0000000000003398. Epub ahead of print. PMID: 40066778. |
Zinc finger protein Znf296 is a cardiac-specific splicing regulator required for cardiomyocyte formation
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Citation:
Am J Pathol. 2025 Mar 21:S0002-9440(25)00078-1. doi: 10.1016/j.ajpath.2025.02.006. Epub ahead of print. PMID: 40122456 Epub:
Not Epub Abstract:
Heart formation and function are tightly regulated at transcriptional and post-transcriptional levels. The dysfunction of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Li X, Yang S, Wang L, Zhang X, Zhang A, Wang Y, Shi DL, Li H. Zinc finger protein Znf296 is a cardiac-specific splicing regulator required for cardiomyocyte formation. Am J Pathol. 2025 Mar 21:S0002-9440(25)00078-1. doi: 10.1016/j.ajpath.2025.02.006. Epub ahead of print. PMID: 40122456. |
The Interaction Between the asb5a and asb5b Subtypes Jointly Regulates the L-R Asymmetrical Development of the Heart in Zebrafish
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Citation:
Int. J. Mol. Sci. 2025, 26, 2765. https://doi.org/10.3390/ijms26062765 Epub:
Not Epub Abstract:
The asb5 gene, a member of the Asb protein subfamily characterized by six ankyrin repeat domains, is highly conserved and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhou W, Cai W, Li Y, Gao L, Liu X, Liu S, Lei J, Zhang J, Wang Y, Jiang Z, Wu X, Fan X, Li F, Zheng L, Yuan W. The Interaction Between the asb5a and asb5b Subtypes Jointly Regulates the L-R Asymmetrical Development of the Heart in Zebrafish. Int. J. Mol. Sci. 2025, 26, 2765. https://doi.org/10.3390/ijms26062765. |
TRAP1 functions in the morphogenesis of the embryonic kidney
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Citation:
Anim Cells Syst (Seoul). 2025 Mar 12;29(1):9-18. doi: 10.1080/19768354.2025.2477789. PMID: 40098710; PMCID: PMC11912273 Epub:
Not Epub Abstract:
TNF receptor-associated protein1 (TRAP1) is a mitochondrial molecular chaperon with high homology with a cytosolic chaperon... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Kim HE, Kwon T, Sim HJ, Park TJ
. TRAP1 functions in the morphogenesis of the embryonic kidney. Anim Cells Syst (Seoul). 2025 Mar 12;29(1):9-18. doi: 10.1080/19768354.2025.2477789. PMID: 40098710; PMCID: PMC11912273. |