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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11141 scientific papers returned from the database with the search filters currently being used below.

Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential

Authors:
Brombin A, Simpson DJ, Travnickova J, Brunsdon H, Zeng Z, Lu Y, Young AIJ, Chandra T, Patton EE
Citation:
Cell Rep. 2022 Jan 11;38(2):110234. doi: 10.1016/j.celrep.2021.110234
Epub:
Not Epub
Abstract:
Melanocytes, the pigment-producing cells, are replenished from multiple stem cell niches in adult tissue. Although pigmentation...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Brombin A, Simpson DJ, Travnickova J, Brunsdon H, Zeng Z, Lu Y, Young AIJ, Chandra T, Patton EE. Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential. Cell Rep. 2022 Jan 11;38(2):110234. doi: 10.1016/j.celrep.2021.110234.

Numb is required for optimal contraction of skeletal muscle

Authors:
De Gasperi R, Mo C, Azulai D, Wang Z, Harlow LM, Du Y, Graham Z, Pan J, Liu XH, Guo L, Zhang B, Ko F, Raczkowski AM, Bauman WA, Goulbourne CN, Zhao W, Brotto M, Cardozo CP
Citation:
J Cachexia Sarcopenia Muscle. 2022 Jan 9. doi: 10.1002/jcsm.12907. Online ahead of print
Epub:
Yes
Abstract:
Background: The role of Numb, a protein that is important for cell fate and development and that, in human muscle, is expressed...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: mouse primary myoblasts, myotubes
Citation Extract:
De Gasperi R, Mo C, Azulai D, Wang Z, Harlow LM, Du Y, Graham Z, Pan J, Liu XH, Guo L, Zhang B, Ko F, Raczkowski AM, Bauman WA, Goulbourne CN, Zhao W, Brotto M, Cardozo CP. Numb is required for optimal contraction of skeletal muscle. J Cachexia Sarcopenia Muscle. 2022 Jan 9. doi: 10.1002/jcsm.12907. Online ahead of print.

An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes

Authors:
Budzak J, Jones R, Tschudi C, Kolev NG, Rudenko G
Citation:
Nat Commun. 2022 Jan 10;13(1):101. doi: 10.1038/s41467-021-27625-6
Epub:
Not Epub
Abstract:
A Variant Surface Glycoprotein (VSG) coat protects bloodstream form Trypanosoma brucei. Prodigious amounts of VSG mRNA (~7-10%...
Delivery Method:
electroporation
Organism or Cell Type:
Trypanosoma brucei
Citation Extract:
Budzak J, Jones R, Tschudi C, Kolev NG, Rudenko G. An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes. Nat Commun. 2022 Jan 10;13(1):101. doi: 10.1038/s41467-021-27625-6.

Wnt11 family dependent morphogenesis during frog gastrulation is marked by the cleavage furrow protein anillin

Authors:
Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW
Citation:
bioRxiv. 2022;[preprint] doi:/10.1101/2022.01.07.475368
Epub:
Not Epub
Abstract:
Wnt11 family proteins are ligands that activate a type of Dishevelled-mediated, non-canonical Wnt signaling pathway. Loss of...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Van Itallie ES, Field CM, Mitchison TJ, Kirschner MW. Wnt11 family dependent morphogenesis during frog gastrulation is marked by the cleavage furrow protein anillin. bioRxiv. 2022;[preprint] doi:/10.1101/2022.01.07.475368.

Esco2 and cohesin regulate CRL4 ubiquitin ligase ddb1 expression and thalidomide teratogenicity

Authors:
Sanchez AC, Thren ED, Iovine MK, Skibbens RV
Citation:
Cell Cycle. 2022;[Epub] doi:10.1080/15384101.2021.2023304
Epub:
Yes
Abstract:
Cornelia de Lange syndrome (CdLS) and Roberts syndrome (RBS) are severe developmental maladies that arise from mutation of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sanchez AC, Thren ED, Iovine MK, Skibbens RV. Esco2 and cohesin regulate CRL4 ubiquitin ligase ddb1 expression and thalidomide teratogenicity. Cell Cycle. 2022;[Epub] doi:10.1080/15384101.2021.2023304.

Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-PRC1 axis

Authors:
Wang D, Tanaka-Yano M, Meader E, Kinney MA, Morris V, da Rocha EL, Liu N, Orkin SH, North TE, Daley GQ, Rowe RG
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.01.05.474696
Epub:
Not Epub
Abstract:
Hematopoiesis changes over life to meet the demands of maturation and aging. Here, we find that the definitive hematopoietic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang D, Tanaka-Yano M, Meader E, Kinney MA, Morris V, da Rocha EL, Liu N, Orkin SH, North TE, Daley GQ, Rowe RG. Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-PRC1 axis. bioRxiv. 2022;[preprint] doi:10.1101/2022.01.05.474696.

Open reading frame correction using splice-switching antisense oligonucleotides for the treatment of cystic fibrosis

Authors:
Michaels WE, Pena-Rasgado C, Kotaria R, Bridges RJ, Hastings ML
Citation:
Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2114886119. doi: 10.1073/pnas.2114886119
Epub:
Not Epub
Abstract:
CFTR gene mutations that result in the introduction of premature termination codons (PTCs) are common in cystic fibrosis (CF)....
Delivery Method:
Endo-Porter, osmotic shock
Organism or Cell Type:
cell culture: CFF16hBEge-W1282X-SCC:3F2, primary hBE
Citation Extract:
Michaels WE, Pena-Rasgado C, Kotaria R, Bridges RJ, Hastings ML. Open reading frame correction using splice-switching antisense oligonucleotides for the treatment of cystic fibrosis. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2114886119. doi: 10.1073/pnas.2114886119.

Evolutionary distinct roles of γ-secretase subunit nicastrin in zebrafish and humans

Authors:
Hermasch MA, Janning H, Perera RP, Schnabel V, Rostam N, Ramos-Gomes F, Muschalek W, Bennemann A, Alves F, Ralser DJ, Betz RC, Schön MP, Dosch R, Frank J
Citation:
J Dermatol Sci. 2022 Jan 5:S0923-1811(22)00001-9. doi: 10.1016/j.jdermsci.2022.01.001. Online ahead of print
Epub:
Yes
Abstract:
Background: Mutations in the genes that encode the human γ-secretase subunits Presenilin-1, Presenilin Enhancer Protein 2, and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hermasch MA, Janning H, Perera RP, Schnabel V, Rostam N, Ramos-Gomes F, Muschalek W, Bennemann A, Alves F, Ralser DJ, Betz RC, Schön MP, Dosch R, Frank J. Evolutionary distinct roles of γ-secretase subunit nicastrin in zebrafish and humans. J Dermatol Sci. 2022 Jan 5:S0923-1811(22)00001-9. doi: 10.1016/j.jdermsci.2022.01.001. Online ahead of print.

In Vivo Modeling of Zebrafish Zinc Finger, MIZ-Type Containing 1 (ZMIZ1) Expression and its Effect on Pigmentation

Authors:
Sun Y, Liu T, Mi Z, Wang C, Sun L, Ge K, Sheng D, Liu H, Zhang F
Citation:
International journal of dermatology and venereology 2021;[Epub] doi:10.1097/JD9.0000000000000150
Epub:
Yes
Abstract:
Objective: We conducted this study to investigate the role of Zinc Finger MIZ-Type Containing 1 (ZMIZ1) in pigmentation remains...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sun Y, Liu T, Mi Z, Wang C, Sun L, Ge K, Sheng D, Liu H, Zhang F. In Vivo Modeling of Zebrafish Zinc Finger, MIZ-Type Containing 1 (ZMIZ1) Expression and its Effect on Pigmentation. International journal of dermatology and venereology 2021;[Epub] doi:10.1097/JD9.0000000000000150.

Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression

Authors:
Bizen N, Bepari AK, Zhou L, Abe M, Sakimura K, Ono K, Takebayashi H
Citation:
Cell Death Differ. 2022 Jan 1. doi: 10.1038/s41418-021-00915-8. Online ahead of print
Epub:
Yes
Abstract:
Olig2 is indispensable for motoneuron and oligodendrocyte fate-specification in the pMN domain of embryonic spinal cords, and...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mouse embryo E14.5
Citation Extract:
Bizen N, Bepari AK, Zhou L, Abe M, Sakimura K, Ono K, Takebayashi H. Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression. Cell Death Differ. 2022 Jan 1. doi: 10.1038/s41418-021-00915-8. Online ahead of print.

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