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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12165 scientific papers returned from the database with the search filters currently being used below.

Bnip3lb-driven mitophagy maintains fate of the embryonic hematopoietic stem cell pool

Authors:
Meader E, Walcheck MT, Leder MR, Delaney P, Falchetti M, Jing R, Li C, Kambli NK, Wrighton PJ, Sugden WW, Najia MA, Oderberg IM, Taylor VM, LeBlanc ZC, Quenzer ED, Lim SE, Schlaeger T, Daley GQ, Goessling W, North TE
Citation:
Nat Commun. 2026 Feb 24. doi: 10.1038/s41467-026-69593-9. Epub ahead of print. PMID: 41735276
Epub:
Not Epub
Abstract:
Embryonic hematopoietic stem and progenitor cells (HSPCs) have the clinically valuable ability to undergo substantial...
Link:
https://www.nature.com/articles/s41467-026-69593-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Meader E, Walcheck MT, Leder MR, Delaney P, Falchetti M, Jing R, Li C, Kambli NK, Wrighton PJ, Sugden WW, Najia MA, Oderberg IM, Taylor VM, LeBlanc ZC, Quenzer ED, Lim SE, Schlaeger T, Daley GQ, Goessling W, North TE. Bnip3lb-driven mitophagy maintains fate of the embryonic hematopoietic stem cell pool. Nat Commun. 2026 Feb 24. doi: 10.1038/s41467-026-69593-9. Epub ahead of print. PMID: 41735276.

Transposable element–gene chimera cartography, origination and role in enhancing transcriptome plasticity

Authors:
Cheon Y, Alvstad EG, Torre D, Quach DT, Nguyen J, Hyun K, Zhou M, Yu T, Liu L, Yoon Y, Reese F, Faraone L, Li Y, Arnold FJ, Fstkchyan YS, Basu U, Kvon E, Valente EM, Ho JSY, Byun M, Guccione E, Shi Y, Weng Z, Seldin M, Marazzi I
Citation:
Nat Struct Mol Biol (2026)
Epub:
Not Epub
Abstract:
Transposable elements (TEs) in the human genome are the heritage of ancient parasitic infections. While most of human DNA...
Link:
https://www.nature.com/articles/s41594-026-01757-z
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: mouse embryonic stem cells
Citation Extract:
Cheon Y, Alvstad EG, Torre D, Quach DT, Nguyen J, Hyun K, Zhou M, Yu T, Liu L, Yoon Y, Reese F, Faraone L, Li Y, Arnold FJ, Fstkchyan YS, Basu U, Kvon E, Valente EM, Ho JSY, Byun M, Guccione E, Shi Y, Weng Z, Seldin M, Marazzi I. Transposable element–gene chimera cartography, origination and role in enhancing transcriptome plasticity. Nat Struct Mol Biol (2026).

Patient-informed CRISPR screen identifies FLNB as a congenital heart disease and ciliopathy gene

Authors:
Arrigo A, Rao V, Ratan A, Kulkarni SS
Citation:
HGG Adv. 2026 Feb 10;7(2):100580. doi: 10.1016/j.xhgg.2026.100580. Epub ahead of print. PMID: 41674076
Epub:
Not Epub
Abstract:
Heterotaxy (HTX) is a congenital disorder characterized by abnormal left-right organ placement, often leading to severe...
Link:
https://www.cell.com/hgg-advances/fulltext/S2666-2477(26)00020-5
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Arrigo A, Rao V, Ratan A, Kulkarni SS. Patient-informed CRISPR screen identifies FLNB as a congenital heart disease and ciliopathy gene. HGG Adv. 2026 Feb 10;7(2):100580. doi: 10.1016/j.xhgg.2026.100580. Epub ahead of print. PMID: 41674076.

Intravenous miR-30c therapy confers dual neurovascular protection and improves long-term recovery after ischemic stroke

Authors:
Jin R, Shukla M, Zhong W, Hu Y, Li J, Wang M, Li G
Citation:
Neurotherapeutics. 2026 Feb 19:e00858. doi: 10.1016/j.neurot.2026.e00858. Epub ahead of print. PMID: 41720714
Epub:
Not Epub
Abstract:
Ischemia–reperfusion (I/R) injury is a major barrier to effective reperfusion therapy in acute ischemic stroke. Secondary...
Link:
https://www.sciencedirect.com/science/article/pii/S1878747926000280
Delivery Method:
Vivo-Morpholino; intravenous (i.v.) injection
Organism or Cell Type:
C57BL/6J mice
Citation Extract:
Jin R, Shukla M, Zhong W, Hu Y, Li J, Wang M, Li G. Intravenous miR-30c therapy confers dual neurovascular protection and improves long-term recovery after ischemic stroke. Neurotherapeutics. 2026 Feb 19:e00858. doi: 10.1016/j.neurot.2026.e00858. Epub ahead of print. PMID: 41720714.

Protocol for blastomere injection to generate bilateral hemimosaic Xenopus tadpoles

Authors:
Li VJ, Kesner PM, Schohl A, Foubert D, Benfey N, Ruthazer ES
Citation:
STAR Protoc. 2026 Feb 19;7(1):104387. doi: 10.1016/j.xpro.2026.104387. Epub ahead of print. PMID: 41719136
Epub:
Not Epub
Abstract:
Here, we present a protocol to generate bilateral hemimosaic Xenopus tadpoles that allows systematic, independent manipulation...
Link:
https://www.sciencedirect.com/science/article/pii/S2666166726000407
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Li VJ, Kesner PM, Schohl A, Foubert D, Benfey N, Ruthazer ES. Protocol for blastomere injection to generate bilateral hemimosaic Xenopus tadpoles. STAR Protoc. 2026 Feb 19;7(1):104387. doi: 10.1016/j.xpro.2026.104387. Epub ahead of print. PMID: 41719136.

A simple and highly sensitive LC-MS/MS bioanalytical method for phosphorodiamidate morpholino oligonucleotides in plasma

Authors:
Kameyama T, Imai S, Mitamura R, Niwa M, Yamada T, Kusano K
Citation:
Bioanalysis. 2026 Feb 19:1-13. doi: 10.1080/17576180.2026.2632688. Epub ahead of print. PMID: 41711019
Epub:
Not Epub
Abstract:
Background: LC-MS/MS is widely used for the quantification of phosphorodiamidate morpholino oligomers, but its low sensitivity...
Link:
https://www.tandfonline.com/doi/full/10.1080/17576180.2026.2632688
Organism or Cell Type:
PMO-spiked rat and human plasma
Citation Extract:
Kameyama T, Imai S, Mitamura R, Niwa M, Yamada T, Kusano K. A simple and highly sensitive LC-MS/MS bioanalytical method for phosphorodiamidate morpholino oligonucleotides in plasma. Bioanalysis. 2026 Feb 19:1-13. doi: 10.1080/17576180.2026.2632688. Epub ahead of print. PMID: 41711019.

A Suspended Graphene Field-Effect Transistor for Ultra-Sensitive and Label-Free Detection of Cancer Biomarker miR-21

Authors:
Deng Z, Zeng C, Wu Q, Zhang F, Zhuang P
Citation:
Biosensors. 2026; 16(2):125. https://doi.org/10.3390/bios16020125
Epub:
Not Epub
Abstract:
The sensitive detection of microRNA-21 (miR-21), a key biomarker for various cancers, is crucial for early diagnosis, yet...
Link:
https://www.mdpi.com/2079-6374/16/2/125
Delivery Method:
PMO probe to capture synthetic miR-21
Citation Extract:
Deng Z, Zeng C, Wu Q, Zhang F, Zhuang P. A Suspended Graphene Field-Effect Transistor for Ultra-Sensitive and Label-Free Detection of Cancer Biomarker miR-21. Biosensors. 2026; 16(2):125. https://doi.org/10.3390/bios16020125.

Insulin-like growth factor signaling regulates zebrafish lymphatic-vessel development

Authors:
Chen W, Misa JP, Herbert CD, Watkin B, Stevenson TJ, McCullough SJC, Lee KL, Bohlander SK, Hoyle DJ, Crosier PS, Schilling TF, Rustenhoven J, Hall CJ, Astin JW
Citation:
Cell Rep. 2026 Feb 13;45(2):116971. doi: 10.1016/j.celrep.2026.116971. Epub ahead of print. PMID: 41691624
Epub:
Not Epub
Abstract:
The coordinated migration of lymphatic endothelial cells (LECs) is essential for the development of the lymphatic network. Here...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00049-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen W, Misa JP, Herbert CD, Watkin B, Stevenson TJ, McCullough SJC, Lee KL, Bohlander SK, Hoyle DJ, Crosier PS, Schilling TF, Rustenhoven J, Hall CJ, Astin JW. Insulin-like growth factor signaling regulates zebrafish lymphatic-vessel development. Cell Rep. 2026 Feb 13;45(2):116971. doi: 10.1016/j.celrep.2026.116971. Epub ahead of print. PMID: 41691624.

Targeted blocking of gene splicing can dysregulate intron-embedded primary microRNAs

Authors:
Ali MH, Ramesh AR, Nedunchezhian N, Kwiatkowski W, Kopeć P, Kowalewska N, Pęcherz S, Gnutti B, Finazzi D, Anbalagan S
Citation:
Commun Biol. 2026 Feb 16;9(1):252. doi: 10.1038/s42003-026-09529-7. PMID: 41699380; PMCID: PMC12910030
Epub:
Not Epub
Abstract:
Addressing whether antisense oligonucleotides (ASOs)-based targeting of genes embedded with intronic noncoding RNAs (ncRNAs)...
Link:
https://www.nature.com/articles/s42003-026-09529-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ali MH, Ramesh AR, Nedunchezhian N, Kwiatkowski W, Kopeć P, Kowalewska N, Pęcherz S, Gnutti B, Finazzi D, Anbalagan S. Targeted blocking of gene splicing can dysregulate intron-embedded primary microRNAs. Commun Biol. 2026 Feb 16;9(1):252. doi: 10.1038/s42003-026-09529-7. PMID: 41699380; PMCID: PMC12910030.

Spatiotemporal coordination of Slit-Robo repulsion and neurturin-Gfrα attraction guides multipolar migration during retinal lamination

Authors:
Lehtimäki JI, Lilue J, Cruz MR, Del Rosario M, Nerli E, Henriques R, Norden C
Citation:
Cell Rep. 2026 Feb 3;45(2):116948. doi: 10.1016/j.celrep.2026.116948. Epub ahead of print. PMID: 41642709
Epub:
Not Epub
Abstract:
Multipolar migration is a conserved neuronal migration mode in the developing brain, enabling emerging neurons to navigate in...
Link:
https://www.sciencedirect.com/science/article/pii/S2211124726000264
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lehtimäki JI, Lilue J, Cruz MR, Del Rosario M, Nerli E, Henriques R, Norden C. Spatiotemporal coordination of Slit-Robo repulsion and neurturin-Gfrα attraction guides multipolar migration during retinal lamination. Cell Rep. 2026 Feb 3;45(2):116948. doi: 10.1016/j.celrep.2026.116948. Epub ahead of print. PMID: 41642709.

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