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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12214 scientific papers returned from the database with the search filters currently being used below.

SIX1 branchio-oto-renal syndrome variants have different effects on embryonic craniofacial gene expression and cartilage formation

Authors:
Coppenrath K, Shaidani NI, Naert T, Majumdar HD, Horb M, Lienkamp SS, Klein SL, Moody SA
Citation:
Development. 2026 Jul 1;153(13):dev205428. doi: 10.1242/dev.205428. Epub 2026 Jul 6. PMID: 42290293
Epub:
Not Epub
Abstract:
SIX1 variants underlying branchio-oto-renal syndrome occur in the SIX domain (SD) or homeodomain (HD). We tested whether...
Link:
https://journals.biologists.com/dev/article/153/13/dev205428/372167/SIX1-branchio-oto-renal-syndrome-variants-have
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Coppenrath K, Shaidani NI, Naert T, Majumdar HD, Horb M, Lienkamp SS, Klein SL, Moody SA. SIX1 branchio-oto-renal syndrome variants have different effects on embryonic craniofacial gene expression and cartilage formation. Development. 2026 Jul 1;153(13):dev205428. doi: 10.1242/dev.205428. Epub 2026 Jul 6. PMID: 42290293.

LINC00607 facilitates endothelial VEGF-A receptor FLT1 splicing

Authors:
Lam F, Warwick T, Oo JA, Krüger AY, Kreis NN, Diagel A, Izquierdo Ponce J, Tirunagari P, Bayer ME, Nonn O, Dechend R, Walther T, Boon RA, Baker AH, Günther S, Wittig I, Chen Z, Müller-McNicoll M, Louwen F, Brandes RP, Leisegang MS
Citation:
Mol Ther. 2026 Jul 1;34(7):4323-4338. doi: 10.1016/j.ymthe.2026.03.038. Epub 2026 Apr 4. PMID: 41935951; PMCID: PMC13330067
Epub:
Not Epub
Abstract:
Angiogenesis is a key function of vascular endothelial cells and becomes aberrant in pathologies such as preeclampsia. An...
Link:
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(26)00265-0
Delivery Method:
electroporation
Organism or Cell Type:
human umbilical vein endothelial cells (HUVECs)
Citation Extract:
Lam F, Warwick T, Oo JA, Krüger AY, Kreis NN, Diagel A, Izquierdo Ponce J, Tirunagari P, Bayer ME, Nonn O, Dechend R, Walther T, Boon RA, Baker AH, Günther S, Wittig I, Chen Z, Müller-McNicoll M, Louwen F, Brandes RP, Leisegang MS. LINC00607 facilitates endothelial VEGF-A receptor FLT1 splicing. Mol Ther. 2026 Jul 1;34(7):4323-4338. doi: 10.1016/j.ymthe.2026.03.038. Epub 2026 Apr 4. PMID: 41935951; PMCID: PMC13330067.

ATP6V1B2 Regulating Autophagy Flux To Affect Abnormal Auditory Development

Authors:
Feng Z, Li J, Yang Y, Chen M, Wu X, Zhou C
Citation:
Appl Biochem Biotechnol. 2026 Jul;198(7):5330-5345. doi: 10.1007/s12010-025-05579-5. Epub 2026 Apr 17. PMID: 41995948
Epub:
Not Epub
Abstract:
To investigate the expression changes of ATP6V1B2 downregulation in Dominant Deafness-Onychodystrophy syndrome (DDOD syndrome...
Link:
https://link.springer.com/article/10.1007/s12010-025-05579-5
Delivery Method:
cochlear microinjection
Organism or Cell Type:
mice
Citation Extract:
Feng Z, Li J, Yang Y, Chen M, Wu X, Zhou C. ATP6V1B2 Regulating Autophagy Flux To Affect Abnormal Auditory Development. Appl Biochem Biotechnol. 2026 Jul;198(7):5330-5345. doi: 10.1007/s12010-025-05579-5. Epub 2026 Apr 17. PMID: 41995948.

Exploring neutral backbones in phosphorodiamidate morpholino oligomers: synthesis and biophysical properties

Authors:
Das A, Kuilya D, Sharma SN, Sinha S
Citation:
Chem Commun (Camb). 2026 Jun 25. doi: 10.1039/d6cc01842d. Epub ahead of print. PMID: 42347830
Epub:
Not Epub
Abstract:
The synthesis of morpholino dimer chlorophosphoramidates and phosphoramidites has been successfully achieved and the method has...
Link:
https://pubs.rsc.org/en/content/articlelanding/2026/cc/d6cc01842d
Delivery Method:
none
Organism or Cell Type:
PMO-DNA and PMO-RNA
Citation Extract:
Das A, Kuilya D, Sharma SN, Sinha S. Exploring neutral backbones in phosphorodiamidate morpholino oligomers: synthesis and biophysical properties. Chem Commun (Camb). 2026 Jun 25. doi: 10.1039/d6cc01842d. Epub ahead of print. PMID: 42347830.

Rapid and sensitive detection of RNA biomarkers using morpholino-functionalized organic electrochemical transistor

Authors:
Zhou R, Yang Q, Yang Q, Yu J, Zheng J, Yan H, Jiang X, Chen M, Liang Z, Jia Y, Segal E, Dong H, Guo K
Citation:
Chemical Engineering Journal. Volume 533, 2026, 174656. ISSN 1385-8947. doi: 10.1016/j.cej.2026.174656
Epub:
Not Epub
Abstract:
Ribonucleic acid (RNA) biomarkers have emerged as vital molecular indicators in precision medicine, with accurate detection...
Link:
https://www.sciencedirect.com/science/article/pii/S1385894726021157
Delivery Method:
none
Organism or Cell Type:
SARS-CoV-2 viral RNA
Citation Extract:
Zhou R, Yang Q, Yang Q, Yu J, Zheng J, Yan H, Jiang X, Chen M, Liang Z, Jia Y, Segal E, Dong H, Guo K. Rapid and sensitive detection of RNA biomarkers using morpholino-functionalized organic electrochemical transistor. Chemical Engineering Journal. Volume 533, 2026, 174656. ISSN 1385-8947. doi: 10.1016/j.cej.2026.174656.

A Splice-Site Variant in ACY1 Associated with Congenital Hearing Loss: Clinical, Biochemical, and Zebrafish Functional Evidence

Authors:
Yu S, Xu Z, Wang H, Chen L, Hu SW, Zhang Y, Lyu H, Wu H, Wu M, Shu Y, Chen W
Citation:
Biochem Genet. 2026 Jun 20. doi: 10.1007/s10528-026-11417-y. Epub ahead of print. PMID: 42322530
Epub:
Not Epub
Abstract:
Variants in the aminoacylase 1 (ACY1) gene are associated with diverse clinical phenotypes, but their roles in hearing loss...
Link:
https://link.springer.com/article/10.1007/s10528-026-11417-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yu S, Xu Z, Wang H, Chen L, Hu SW, Zhang Y, Lyu H, Wu H, Wu M, Shu Y, Chen W. A Splice-Site Variant in ACY1 Associated with Congenital Hearing Loss: Clinical, Biochemical, and Zebrafish Functional Evidence. Biochem Genet. 2026 Jun 20. doi: 10.1007/s10528-026-11417-y. Epub ahead of print. PMID: 42322530.

Kinetic and thermodynamic properties of phosphorothioate and phosphorodiamidate morpholino oligonucleotides binding to target RNA

Authors:
Hasegawa T, Sato K, Hara RI, Wada T, Sakamoto T
Citation:
J Biochem. 2026 Jun 19:mvag043. doi: 10.1093/jb/mvag043. Epub ahead of print. PMID: 42317169
Epub:
Not Epub
Abstract:
Recently, numerous nucleic acid therapeutics have been developed, and a substantial number of the approved agents are...
Link:
https://academic.oup.com/jb/advance-article-abstract/doi/10.1093/jb/mvag043/8711525
Delivery Method:
none
Organism or Cell Type:
none
Citation Extract:
Hasegawa T, Sato K, Hara RI, Wada T, Sakamoto T. Kinetic and thermodynamic properties of phosphorothioate and phosphorodiamidate morpholino oligonucleotides binding to target RNA. J Biochem. 2026 Jun 19:mvag043. doi: 10.1093/jb/mvag043. Epub ahead of print. PMID: 42317169.

The ezrin Gene Regulates Early Cardiac Morphogenesis and Contractile Function in Zebrafish Through the Coordinated Regulation of Apoptosis, Calcium Homeostasis, and the MAPK Signaling Pathway

Authors:
Lv J, Zeng T, Liao B, Liu L, Xiong L, Xie H, Zhu L, Jiang X, Zhong Z, Xie H
Citation:
Cells. 2026; 15(12):1046. https://doi.org/10.3390/cells15121046
Epub:
Not Epub
Abstract:
Ezrin, expressed by the EZR gene, is a member of the ERM protein family that connects the plasma membrane to the actin...
Link:
https://www.mdpi.com/2073-4409/15/12/1046
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lv J, Zeng T, Liao B, Liu L, Xiong L, Xie H, Zhu L, Jiang X, Zhong Z, Xie H. The ezrin Gene Regulates Early Cardiac Morphogenesis and Contractile Function in Zebrafish Through the Coordinated Regulation of Apoptosis, Calcium Homeostasis, and the MAPK Signaling Pathway. Cells. 2026; 15(12):1046. https://doi.org/10.3390/cells15121046.

An aquaglyceroporin governs cellular water and CO2 conductance relevant for vesicular mineral formation in a marine calcifier

Authors:
Matt AS, Tetzlaff S, Jonusaite S, Quijada-Rodriguez A, Schewe M, Cordeiro S, Weihrauch D, Hu MY
Citation:
Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2524614123. doi: 10.1073/pnas.2524614123. Epub 2026 Jun 8. PMID: 42258730
Epub:
Not Epub
Abstract:
Many marine organisms generate biominerals by endocytotic uptake of seawater which is modified within calcifying cells to...
Link:
https://www.pnas.org/doi/10.1073/pnas.2524614123
Delivery Method:
microinjection
Organism or Cell Type:
sea urchin larvae
Citation Extract:
Matt AS, Tetzlaff S, Jonusaite S, Quijada-Rodriguez A, Schewe M, Cordeiro S, Weihrauch D, Hu MY. An aquaglyceroporin governs cellular water and CO2 conductance relevant for vesicular mineral formation in a marine calcifier. Proc Natl Acad Sci U S A. 2026 Jun 16;123(24):e2524614123. doi: 10.1073/pnas.2524614123. Epub 2026 Jun 8. PMID: 42258730.

ZL006 Treatment Reduces Inflammation, Oxidative Stress, and Brain Aβ1–42 Accumulation and Rescues the Loss of PSD95 Synaptic Marker in Familial Alzheimer’s Disease-Associated psen1-Deficient Zebrafish Model

Authors:
Ricci S, Benuzzi M, Fazzina M, Cacialli P
Citation:
International Journal of Molecular Sciences. 2026; 27(11):4992. https://doi.org/10.3390/ijms27114992
Epub:
Not Epub
Abstract:
Familial Alzheimer’s disease (FAD) is a rare form of Alzheimer’s. FAD is mainly caused by one or multiple mutations in the...
Link:
https://www.mdpi.com/1422-0067/27/11/4992
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ricci S, Benuzzi M, Fazzina M, Cacialli P. ZL006 Treatment Reduces Inflammation, Oxidative Stress, and Brain Aβ1–42 Accumulation and Rescues the Loss of PSD95 Synaptic Marker in Familial Alzheimer’s Disease-Associated psen1-Deficient Zebrafish Model. International Journal of Molecular Sciences. 2026; 27(11):4992. https://doi.org/10.3390/ijms27114992.

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