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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12198 scientific papers returned from the database with the search filters currently being used below.
There are 12198 scientific papers returned from the database with the search filters currently being used below.
An Anti-Invasive Role for Mdmx through the RhoA GTPase under the Control of the NEDD8 Pathway
Citation:
Cells. 2024; 13(19):1625. https://doi.org/10.3390/cells13191625 Epub:
Not Epub Abstract:
Mdmx (Mdm4) is established as an oncogene mainly through repression of the p53 tumour suppressor. On the other hand, anti-... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Bou Malhab LJ, Schmidt S, Fagotto-Kaufmann C, Pion E, Gadea G, Roux P, Fagotto F, Debant A, Xirodimas DP. An Anti-Invasive Role for Mdmx through the RhoA GTPase under the Control of the NEDD8 Pathway. Cells. 2024; 13(19):1625. https://doi.org/10.3390/cells13191625. |
Self-Assembled Antibody-Oligonucleotide Conjugates for Targeted Delivery of Complementary Antisense Oligonucleotides
Citation:
Angew Chem Int Ed Engl. 2024 Sep 26:e202415272. doi: 10.1002/anie.202415272. Epub ahead of print. PMID: 39325927 Epub:
Not Epub Abstract:
Antibody-oligonucleotide conjugate (AOC) affords preferential cell targeting and enhanced cellular uptake of antisense... Delivery Method:
antibody-linked; mice: intravenous (i.v.) Organism or Cell Type:
cell culture: C2C12; mice: TfR1-humanized C57BL/6 Citation Extract: Pan L, Zhou L, Bi J, Chang S, Bai Z, Yu J, Wang R, Li Z, Zhang X, Chou JJ. Self-Assembled Antibody-Oligonucleotide Conjugates for Targeted Delivery of Complementary Antisense Oligonucleotides. Angew Chem Int Ed Engl. 2024 Sep 26:e202415272. doi: 10.1002/anie.202415272. Epub ahead of print. PMID: 39325927. |
Deciphering the impact of PROM1 alternative splicing on human photoreceptor development and maturation
Citation:
Cell Death Dis. 2024 Oct 1;15(10):721. doi: 10.1038/s41419-024-07105-7. PMID: 39353897 Epub:
Not Epub Abstract:
Alternative splicing (AS) is a crucial mechanism contributing to proteomic diversity, which is highly regulated in tissue- and... Delivery Method:
Endo-Porter PEG Organism or Cell Type:
retinal organoids derived from hiPSCs Citation Extract: Moya-Molina M, Dorgau B, Flood E, Letteboer SJF, Lorentzen E, Coxhead J, Smith G, Roepman R, Nagaraja Grellscheid S, Armstrong L, Lako M. Deciphering the impact of PROM1 alternative splicing on human photoreceptor development and maturation. Cell Death Dis. 2024 Oct 1;15(10):721. doi: 10.1038/s41419-024-07105-7. PMID: 39353897. |
Prox1a promotes liver growth and differentiation by repressing cdx1b expression and intestinal fate transition in zebrafish
Citation:
J Genet Genomics. 2024 Sep 27:S1673-8527(24)00248-0. doi: 10.1016/j.jgg.2024.09.010. Online ahead of print. PMID: 39343095 Epub:
Not Epub Abstract:
The liver is a key endoderm-derived multifunctional organ within the digestive system. Prospero homeobox 1 (Prox1) is an... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Hu Y, Luo Z, Wang M, Wu Z, Liu Y, Cheng Z, Sun Y, Xiong JW, Tong X, Zhu Z, Zhang B. Prox1a promotes liver growth and differentiation by repressing cdx1b expression and intestinal fate transition in zebrafish. J Genet Genomics. 2024 Sep 27:S1673-8527(24)00248-0. doi: 10.1016/j.jgg.2024.09.010. Online ahead of print. PMID: 39343095. |
Deoxyhypusine synthase deficiency syndrome zebrafish model: aberrant morphology, epileptiform activity, and reduced arborization of inhibitory interneurons
Citation:
Mol Brain. 2024 Sep 27;17(1):68. doi: 10.1186/s13041-024-01139-w. PMID: 39334388 Epub:
Not Epub Abstract:
DHPS deficiency syndrome is an ultra-rare neurodevelopmental disorder (NDD) which results from biallelic mutations in the gene... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Shojaeinia E, Mastracci TL, Soliman R, Devinsky O, Esguerra CV, Crawford AD. Deoxyhypusine synthase deficiency syndrome zebrafish model: aberrant morphology, epileptiform activity, and reduced arborization of inhibitory interneurons. Mol Brain. 2024 Sep 27;17(1):68. doi: 10.1186/s13041-024-01139-w. PMID: 39334388. |
Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms
Citation:
Mol Ther. 2022 Jan 5;30(1):295-310. doi: 10.1016/j.ymthe.2021.08.009. Epub 2021 Aug 8. PMID: 34371183; PMCID: PMC8753370 Epub:
Not Epub Abstract:
Activating mutations in c-KIT are associated with the mast cell (MC) clonal disorders cutaneous mastocytosis and systemic... Delivery Method:
cell culture: electroporation; mice: Vivo-Morpholino injection, intravenous (i.v.) & intratumoral Organism or Cell Type:
cell culture: HMC-1.2 & LAD2; mice: DBA/2J Citation Extract: Snider DB, Arthur GK, Falduto GH, Olivera A, Ehrhardt-Humbert LC, Smith E, Smith C, Metcalfe DD, Cruse G. Targeting KIT by frameshifting mRNA transcripts as a therapeutic strategy for aggressive mast cell neoplasms. Mol Ther. 2022 Jan 5;30(1):295-310. doi: 10.1016/j.ymthe.2021.08.009. Epub 2021 Aug 8. PMID: 34371183; PMCID: PMC8753370. |
Fgf8 contributes to the pathogenesis of Nager syndrome
Citation:
International Journal of Biological Macromolecules. Preprint. Available online 15 September 2024, 135692 Epub:
Not Epub Abstract:
Nager syndrome (NS, OMIM 154400) is a rare disease characterized by craniofacial and limb malformations due to variants in... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ulhaq ZS, You M-S, Yabe T, Takada S, Chen J-K, Ogino Y, Jiang Y-J, Tse WKF. Fgf8 contributes to the pathogenesis of Nager syndrome. International Journal of Biological Macromolecules. Preprint. Available online 15 September 2024, 135692. |
Redirecting full-length FLT1 expression towards its soluble isoform promotes postischemic angiogenesis
Citation:
bioRxiv [preprint] 2024.09.19.613989; doi: https://doi.org/10.1101/2024.09.19.613989 Epub:
Not Epub Abstract:
Vascular endothelial growth factors and their tyrosine kinase receptors are key mediators of vasculogenesis and angiogenesis... Delivery Method:
Endo-Porter Organism or Cell Type:
cell culture: mouse SVEC Citation Extract: Bundalo M, Vorlova S, Ulrich J, Barbieri R, Richter L, Höna L, Egg M, Bock J, Schäfer S, Amézaga Solé N, Rosa A, Rizzo G, Cochain C, Kastenmüller W, Henke E, Skryabin BV, Rozhdestvensky TS, Wildgruber M, Lorenz K, Kuhn M, Zernecke A. Redirecting full-length FLT1 expression towards its soluble isoform promotes postischemic angiogenesis. bioRxiv [preprint] 2024.09.19.613989; doi: https://doi.org/10.1101/2024.09.19.613989. |
Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects
Citation:
Autophagy. 2024 Oct;20(10):2164-2185. doi: 10.1080/15548627.2024.2358736. Epub 2024 Sep 24. PMID: 39316747; PMCID: PMC11423671 Epub:
Not Epub Abstract:
degeneration. C9orf72 HRE is associated with lowered levels of C9orf72 expression and its translation results in the production... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: de Calbiac H, Renault S, Haouy G, Jung V, Roger K, Zhou Q, Campanari ML, Chentout L, Demy DL, Marian A, Goudin N, Edbauer D, Guerrera C, Ciura S, Kabashi E. Poly-GP accumulation due to C9orf72 loss of function induces motor neuron apoptosis through autophagy and mitophagy defects. Autophagy. 2024 Oct;20(10):2164-2185. doi: 10.1080/15548627.2024.2358736. Epub 2024 Sep 24. PMID: 39316747; PMCID: PMC11423671. |
Tau accumulation is cleared by the induced expression of VCP via autophagy
Citation:
Acta Neuropathol. 2024 Sep 24;148(1):46. doi: 10.1007/s00401-024-02804-z. PMID: 39316141; PMCID: PMC11422276 Epub:
Not Epub Abstract:
Tauopathy, including frontotemporal lobar dementia and Alzheimer's disease, describes a class of neurodegenerative... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Giong HK, Hyeon SJ, Lee JG, Cho HJ, Park U, Stein TD, Lee J, Yu K, Ryu H, Lee JS. Tau accumulation is cleared by the induced expression of VCP via autophagy. Acta Neuropathol. 2024 Sep 24;148(1):46. doi: 10.1007/s00401-024-02804-z. PMID: 39316141; PMCID: PMC11422276. |