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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12227 scientific papers returned from the database with the search filters currently being used below.

Sunitinib induces macrophage dysfunction and impaired tissue regeneration through suppression of PPARγ

Authors:
Zhang Z, Qiao Q, Li J, Li Q, Yang Y, Zhou Y, Huang H, Chen D, Wang Y and Guo Y
Citation:
Front. Immunol. (2026) 17:1900449. doi: 10.3389/fimmu.2026.1900449
Epub:
Not Epub
Abstract:
Background: Sunitinib is a widely used multi-target tyrosine kinase inhibitor associated with side effects that may impair...
Link:
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1900449/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang Z, Qiao Q, Li J, Li Q, Yang Y, Zhou Y, Huang H, Chen D, Wang Y and Guo Y. Sunitinib induces macrophage dysfunction and impaired tissue regeneration through suppression of PPARγ. Front. Immunol. (2026) 17:1900449. doi: 10.3389/fimmu.2026.1900449.

An antisense method for efficient exon skipping and its application to Duchenne muscular dystrophy

Authors:
Feng P, Gao P, Meng S, Yuan Y, Krainer AR, Hua Y
Citation:
Proc Natl Acad Sci U S A. 2026 Aug 18;123(33):e2606494123. doi: 10.1073/pnas.2606494123. Epub 2026 Aug 10. PMID: 42574620; PMCID: PMC13486594
Epub:
Not Epub
Abstract:
Antisense-mediated exon skipping has been used to treat Duchenne muscular dystrophy (DMD) by restoring the DMD reading frame to...
Link:
https://www.pnas.org/doi/10.1073/pnas.2606494123
Delivery Method:
intravenous (i.v.) infusion for monkeys and injection for mice, no transfection for cells
Organism or Cell Type:
huΔ52 (exon 52 deleted) mice, cynomolgus monkeys; rhabdomyosarcoma (RD) cells
Citation Extract:
Feng P, Gao P, Meng S, Yuan Y, Krainer AR, Hua Y. An antisense method for efficient exon skipping and its application to Duchenne muscular dystrophy. Proc Natl Acad Sci U S A. 2026 Aug 18;123(33):e2606494123. doi: 10.1073/pnas.2606494123. Epub 2026 Aug 10. PMID: 42574620; PMCID: PMC13486594.

Znf131 is required for gastrulation and neurulation in early Xenopus development

Authors:
Knapp J, Cowan RW, Mersereau J, Park JI, Mohammadi D, McCrea PD, Marsden M, Daniel JM
Citation:
Differentiation. 2026 Aug 17:100989
Epub:
Not Epub
Abstract:
Early vertebrate development involves several highly orchestrated morphogenic movements. Two key movements are gastrulation,...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0301468126000599
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Knapp J, Cowan RW, Mersereau J, Park JI, Mohammadi D, McCrea PD, Marsden M, Daniel JM. Znf131 is required for gastrulation and neurulation in early Xenopus development. Differentiation. 2026 Aug 17:100989.

Facile Siderophore Assembly Enables Bacterial Delivery of Nucleic Acid Therapeutics

Authors:
Ramu H, Kuijken P, Poulladofonou G, Pals MJ, Summerton D, Li YF, Velema WA
Citation:
ACS Chem Biol. 2026 Aug 19. doi: 10.1021/acschembio.6c00323. Epub ahead of print. PMID: 42615608
Epub:
Not Epub
Abstract:
Antibiotic resistance is an increasing threat to modern medicine that calls for the discovery of new antibiotics. RNA targeting...
Link:
https://pubs.acs.org/acbcct/article/doi/10.1021/acschembio.6c00323/5276399/Facile-Siderophore-Assembly-Enables-Bacterial
Delivery Method:
PMO-siderophore conjugate
Organism or Cell Type:
E. coli
Citation Extract:
Ramu H, Kuijken P, Poulladofonou G, Pals MJ, Summerton D, Li YF, Velema WA. Facile Siderophore Assembly Enables Bacterial Delivery of Nucleic Acid Therapeutics. ACS Chem Biol. 2026 Aug 19. doi: 10.1021/acschembio.6c00323. Epub ahead of print. PMID: 42615608.

Spermine oxidase promotes oxidative stress during islet inflammation

Authors:
Checkcinco C, Hammoud B, Saavedra XS, Puente AA, Shah H, Tersey SA, Anderson RM, Mirmira RG
Citation:
J Biol Chem. 2026 Aug 7:113412. doi: 10.1016/j.jbc.2026.113412. Epub ahead of print. PMID: 42567516
Epub:
Not Epub
Abstract:
Diabetes is characterized by impaired glucose homeostasis resulting from dysfunction and loss of insulin-producing islet β...
Link:
https://www.jbc.org/article/S0021-9258(26)02284-2/fulltext
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Checkcinco C, Hammoud B, Saavedra XS, Puente AA, Shah H, Tersey SA, Anderson RM, Mirmira RG. Spermine oxidase promotes oxidative stress during islet inflammation. J Biol Chem. 2026 Aug 7:113412. doi: 10.1016/j.jbc.2026.113412. Epub ahead of print. PMID: 42567516.

Architecture of distal tips of motile cilia is shaped by the pseudoenzyme Jhc1 in non-mammalian vertebrates

Authors:
Hong J, Nair SR, Atayeter E, Jo EL, Gray RS, Young RL, Wallingford JB
Citation:
Cell Rep. 2026 Jul 31;45(8):117727. doi: 10.1016/j.celrep.2026.117727. Epub ahead of print. PMID: 42541726
Epub:
Not Epub
Abstract:
Motile cilia are evolutionarily conserved organelles performing essential roles in development and tissue homeostasis. Unlike...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00805-3
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Hong J, Nair SR, Atayeter E, Jo EL, Gray RS, Young RL, Wallingford JB. Architecture of distal tips of motile cilia is shaped by the pseudoenzyme Jhc1 in non-mammalian vertebrates. Cell Rep. 2026 Jul 31;45(8):117727. doi: 10.1016/j.celrep.2026.117727. Epub ahead of print. PMID: 42541726.

Neutral Backbone Modifications Enhance the Pharmacokinetics and Biodistribution of Antibody–Oligonucleotide Conjugates with High Drug-to-Antibody Ratios

Authors:
Michael Cochran, Subbarao Nallagatla, Giuseppe Dello Iacono, Sami Abdulkadir, Danny Arias, Maryam Jordan, Hae Won Kwon, Arthur Levin, Michael Hood, Philip Kovach, Aidan Kim, Rob Burke, Barbora Malecova, Venkata Ramana Doppalapudi
Citation:
J. Med. Chem. 2026; https://doi.org/10.1021/acs.jmedchem.6c00565
Epub:
Not Epub
Abstract:
Antibody–oligonucleotide conjugates (AOCs) enable targeted delivery of small interfering RNAs (siRNAs) by coupling them to...
Link:
https://pubs.acs.org/jmcmar/article/doi/10.1021/acs.jmedchem.6c00565/5251006/Neutral-Backbone-Modifications-Enhance-the
Delivery Method:
RNA/PMO heteroduplex; Lipofectamine RNAiMAX for cells, intravenous (i.v) injection for mice
Organism or Cell Type:
cell culture: SJCRH30; Hsd:ICR mice
Citation Extract:
Michael Cochran, Subbarao Nallagatla, Giuseppe Dello Iacono, Sami Abdulkadir, Danny Arias, Maryam Jordan, Hae Won Kwon, Arthur Levin, Michael Hood, Philip Kovach, Aidan Kim, Rob Burke, Barbora Malecova, Venkata Ramana Doppalapudi. Neutral Backbone Modifications Enhance the Pharmacokinetics and Biodistribution of Antibody–Oligonucleotide Conjugates with High Drug-to-Antibody Ratios. J. Med. Chem. 2026; https://doi.org/10.1021/acs.jmedchem.6c00565.

Astrocyte activation mediates UV filter PBSA-induced impairment of neurogenesis via the rxrga/tsp-1 axis during a sensitive developmental window in early life stage zebrafish

Authors:
Yang Q, Tian L, Wang J, Qi C, Qian Z, Liu Y, Zhou Y, Chen X, Tao J
Citation:
Chem Biol Interact. 2026 Aug 7:112290. doi: 10.1016/j.cbi.2026.112290. Epub ahead of print. PMID: 42567466
Epub:
Not Epub
Abstract:
2-phenylbenzimidazole-5-sulfonic acid (PBSA), a widely used organic UV filter, is frequently detected in aquatic environments,...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0009279726003984
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang Q, Tian L, Wang J, Qi C, Qian Z, Liu Y, Zhou Y, Chen X, Tao J. Astrocyte activation mediates UV filter PBSA-induced impairment of neurogenesis via the rxrga/tsp-1 axis during a sensitive developmental window in early life stage zebrafish. Chem Biol Interact. 2026 Aug 7:112290. doi: 10.1016/j.cbi.2026.112290. Epub ahead of print. PMID: 42567466.

Structural Optimization of Guanidinium-Linked Morpholino Phosphorodiamidate Morpholino Oligonucleotide Chimeras to Improve In Vitro Antisense Efficacy

Authors:
Qasim M, Naaz S, Pratihar S, Sharma SN, Sinha S
Citation:
Bioconjug Chem. 2026 Jul 21. doi: 10.1021/acs.bioconjchem.6c00176. Epub ahead of print. PMID: 42482424
Epub:
Not Epub
Abstract:
Although phosphorodiamidate morpholino oligomers (PMOs) are potent and stable antisense agents, their neutral backbone limits...
Link:
https://pubs.acs.org/bcches/article-abstract/doi/10.1021/acs.bioconjchem.6c00176/5226235/Structural-Optimization-of-Guanidinium-Linked?redirectedFrom=fulltext
Delivery Method:
guanidinium-linked morpholino oligomers with PMOs
Organism or Cell Type:
cell culture: MCF7 and HCT116
Citation Extract:
Qasim M, Naaz S, Pratihar S, Sharma SN, Sinha S. Structural Optimization of Guanidinium-Linked Morpholino Phosphorodiamidate Morpholino Oligonucleotide Chimeras to Improve In Vitro Antisense Efficacy. Bioconjug Chem. 2026 Jul 21. doi: 10.1021/acs.bioconjchem.6c00176. Epub ahead of print. PMID: 42482424.

A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts

Authors:
Uuganbayar U, Manojlovic Z, Ito N, Yamaguchi R, Ninomiya H, Shimada IS, Yamada C, Feigelson D, Schulz G, Auslander A, Rakotoarison S, Magee W 3rd, Hashimoto Y, Kato Y
Citation:
Genes Cells. 2026 Jul;31(4):e70138. doi: 10.1111/gtc.70138. PMID: 42429105; PMCID: PMC13352469
Epub:
Not Epub
Abstract:
Nonsyndromic cleft lip with or without palate (nCL/P) is a common congenital anomaly with a complex genetic basis. Previous...
Link:
https://onlinelibrary.wiley.com/doi/10.1111/gtc.70138
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Uuganbayar U, Manojlovic Z, Ito N, Yamaguchi R, Ninomiya H, Shimada IS, Yamada C, Feigelson D, Schulz G, Auslander A, Rakotoarison S, Magee W 3rd, Hashimoto Y, Kato Y. A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts. Genes Cells. 2026 Jul;31(4):e70138. doi: 10.1111/gtc.70138. PMID: 42429105; PMCID: PMC13352469.

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