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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11058 scientific papers returned from the database with the search filters currently being used below.

Mechanisms underlying microglial colonization of developing neural retina in zebrafish

Authors:
Ranawat N, Masai I
Citation:
eLife. 2021;10:e70550. doi:10.7554/eLife.70550
Epub:
Not Epub
Abstract:
Microglia are brain-resident macrophages that function as the first line of defense in brain. Embryonic microglial precursors...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ranawat N, Masai I. Mechanisms underlying microglial colonization of developing neural retina in zebrafish. eLife. 2021;10:e70550. doi:10.7554/eLife.70550.

Restoration of Normal NF1 Function with Antisense Morpholino Treatment of Recurrent Pathogenic Patient-Specific Variant c.1466A>G; p.Y489C

Authors:
Awad EK, Moore M, Liu H, Ciszewski L, Lambert L, Korf BR, Popplewell L, Kesterson RA, Wallis D
Citation:
J Pers Med 2021;11(12):1320. doi:10.3390/jpm11121320
Epub:
Not Epub
Abstract:
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder with almost 3000 different disease-causing variants...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human PGP1 iPSC
Citation Extract:
Awad EK, Moore M, Liu H, Ciszewski L, Lambert L, Korf BR, Popplewell L, Kesterson RA, Wallis D. Restoration of Normal NF1 Function with Antisense Morpholino Treatment of Recurrent Pathogenic Patient-Specific Variant c.1466A>G; p.Y489C. J Pers Med 2021;11(12):1320. doi:10.3390/jpm11121320.

Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

Authors:
Ma J, Scott CA, Ho YN, Mahabaleshwar H, Marsay KS, Zhang C, Teow CKJ, Ng SS, Zhang W
Citation:
eLife 2021;10:e66596 doi: 10.7554/eLife.66596
Epub:
Not Epub
Abstract:
Epithelial tissues are primed to respond to insults by activating epithelial cell motility and rapid inflammation. Such...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ma J, Scott CA, Ho YN, Mahabaleshwar H, Marsay KS, Zhang C, Teow CKJ, Ng SS, Zhang W. Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX. eLife 2021;10:e66596 doi: 10.7554/eLife.66596.

Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation

Authors:
Arand J, Chiang HR, Martin D, Snyder MP, Sage J, Reijo Pera RA, Wossidlo M
Citation:
EMBO Rep. 2021 Dec 6:e53968. doi: 10.15252/embr.202153968. Online ahead of print
Epub:
Not Epub
Abstract:
Mammalian development begins in transcriptional silence followed by a period of widespread activation of thousands of genes....
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Arand J, Chiang HR, Martin D, Snyder MP, Sage J, Reijo Pera RA, Wossidlo M. Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation. EMBO Rep. 2021 Dec 6:e53968. doi: 10.15252/embr.202153968. Online ahead of print.

Evaluation of endogenous miRNA reference genes across different zebrafish strains, developmental stages and kidney disease models

Authors:
Siegerist F, Lange T, Iervolino A, Koppe TM, Zhou W, Capasso G, Endlich K, Endlich N
Citation:
Sci Rep. 2021;11(1):22894. doi:10.1038/s41598-021-00075-2
Epub:
Not Epub
Abstract:
The majority of kidney diseases arise from the loss of podocytes and from morphological changes of their highly complex foot...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Siegerist F, Lange T, Iervolino A, Koppe TM, Zhou W, Capasso G, Endlich K, Endlich N. Evaluation of endogenous miRNA reference genes across different zebrafish strains, developmental stages and kidney disease models. Sci Rep. 2021;11(1):22894. doi:10.1038/s41598-021-00075-2.

RGS2 Suppresses Melanoma Growth via Inhibiting MAPK and AKT Signaling Pathways

Authors:
Lin SJ, Huang YC, Chen HY, Fang JY, Hsu SY, Shih HY, Liu YC, Cheng YC
Citation:
Anticancer Res. 2021 Dec;41(12):6135-6145. doi: 10.21873/anticanres.15433
Epub:
Not Epub
Abstract:
Background/Aim: This study aimed to explore RGS2 as a regulator of melanoma cell growth. Materials and Methods: Effect of RGS2...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin SJ, Huang YC, Chen HY, Fang JY, Hsu SY, Shih HY, Liu YC, Cheng YC. RGS2 Suppresses Melanoma Growth via Inhibiting MAPK and AKT Signaling Pathways. Anticancer Res. 2021 Dec;41(12):6135-6145. doi: 10.21873/anticanres.15433.

A Dystrophin Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping

Authors:
Echigoya Y, Trieu N, Duddy W, Moulton HM, Yin H, Partridge TA, Hoffman EP, Kornegay JN, Rohret FA, Rogers CS, Yokota T
Citation:
Int J Mol Sci. 2021;22(23):13065. doi:10.3390/ijms222313065
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive disorder caused by mutations in the DMD gene and the...
Delivery Method:
peptide-linked, Endo-Porter
Organism or Cell Type:
Sus scrofa domestica (pig)
Citation Extract:
Echigoya Y, Trieu N, Duddy W, Moulton HM, Yin H, Partridge TA, Hoffman EP, Kornegay JN, Rohret FA, Rogers CS, Yokota T. A Dystrophin Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping. Int J Mol Sci. 2021;22(23):13065. doi:10.3390/ijms222313065 .

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

Authors:
Bresciani E, Carrington B, Yu K, Kim EM, Zhen T, Guzman VS, Broadbridge E, Bishop K, Kirby M, Harper U, Wincovitch S, Dell'Orso S, Sartorelli V, Sood R, Liu P
Citation:
Blood Adv. 2021 Dec 14;5(23):4949-4962. doi: 10.1182/bloodadvances.2020003969
Epub:
Not Epub
Abstract:
RUNX1 is essential for the generation of hematopoietic stem cells (HSCs). Runx1-null mouse embryos lack definitive...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bresciani E, Carrington B, Yu K, Kim EM, Zhen T, Guzman VS, Broadbridge E, Bishop K, Kirby M, Harper U, Wincovitch S, Dell'Orso S, Sartorelli V, Sood R, Liu P. Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development. Blood Adv. 2021 Dec 14;5(23):4949-4962. doi: 10.1182/bloodadvances.2020003969.

Hapln1b, a central organizer of the ECM, modulates kit signaling to control developmental hematopoiesis in zebrafish

Authors:
Mahony CB, Cacialli P, Pasche C, Monteiro R, Savvides SN, Bertrand JY
Citation:
Blood Adv. 2021 Dec 14;5(23):4935-4948. doi: 10.1182/bloodadvances.2020001524
Epub:
Not Epub
Abstract:
During early vertebrate development, hematopoietic stem and progenitor cells (HSPCs) are produced in hemogenic endothelium...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mahony CB, Cacialli P, Pasche C, Monteiro R, Savvides SN, Bertrand JY. Hapln1b, a central organizer of the ECM, modulates kit signaling to control developmental hematopoiesis in zebrafish. Blood Adv. 2021 Dec 14;5(23):4935-4948. doi: 10.1182/bloodadvances.2020001524.

Tetraspanin Cd9b and Cxcl12a/Cxcr4b have a synergistic effect on the control of collective cell migration

Authors:
Marsay KS, Greaves S, Mahabaleshwar H, Ho CM, Roehl H, Monk PN, Carney TJ, Partridge LJ
Citation:
PLoS ONE. 2021;16(11):e0260372. doi:10.1371/journal.pone.0260372
Epub:
Not Epub
Abstract:
Collective cell migration is essential for embryonic development and homeostatic processes. During zebrafish development, the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Marsay KS, Greaves S, Mahabaleshwar H, Ho CM, Roehl H, Monk PN, Carney TJ, Partridge LJ. Tetraspanin Cd9b and Cxcl12a/Cxcr4b have a synergistic effect on the control of collective cell migration. PLoS ONE. 2021;16(11):e0260372. doi:10.1371/journal.pone.0260372.

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