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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10536 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Rab11fip5 regulates telencephalon development via ephrinB1 recycling

Authors:
Yoon J, Garo J, Lee M, Sun J, Hwang YS, Daar IO
Citation:
Development. 2021 Jan 18:dev.196527. doi: 10.1242/dev.196527. Online ahead of print
Abstract:
Rab11 family-interacting protein 5 (Rab11fip5) is an adaptor protein that binds to the small GTPase Rab11, which has an...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yoon J, Garo J, Lee M, Sun J, Hwang YS, Daar IO. Rab11fip5 regulates telencephalon development via ephrinB1 recycling. Development. 2021 Jan 18:dev.196527. doi: 10.1242/dev.196527. Online ahead of print.

Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish

Authors:
Lu S, Lyu Z, Wang Z, Kou Y, Liu C, Li S, Hu M, Zhu H, Wang W, Zhang C, Kuan YS, Liu YW, Chen J, Tian J
Citation:
Theranostics. 2021 Jan 1;11(6):2788-2805. doi: 10.7150/thno.53330. eCollection 2021
Abstract:
Lipin 1 is an intracellular protein acting as a phosphatidic acid phosphohydrolase enzyme controlling lipid metabolism. Human...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lu S, Lyu Z, Wang Z, Kou Y, Liu C, Li S, Hu M, Zhu H, Wang W, Zhang C, Kuan YS, Liu YW, Chen J, Tian J. Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish. Theranostics. 2021 Jan 1;11(6):2788-2805. doi: 10.7150/thno.53330. eCollection 2021.

Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish

Authors:
Yang L, Webb SE, Jin N, Lee HM, Chan TF, Xu G, Chan JCN, Miller AL, Ma RCW
Citation:
J Diabetes Investig. 2021 Jan 15. doi: 10.1111/jdi.13503. Online ahead of print
Abstract:
Aims/introduction: β-cell dysfunction is a hallmark of type 2 diabetes. In a previous pilot study, we identified an association...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang L, Webb SE, Jin N, Lee HM, Chan TF, Xu G, Chan JCN, Miller AL, Ma RCW. Investigating the role of dachshund b in the development of the pancreatic islet in zebrafish. J Diabetes Investig. 2021 Jan 15. doi: 10.1111/jdi.13503. Online ahead of print.

Single-cell analysis of non-human primate preimplantation development in comparison to humans and mice

Authors:
Hu Y, Huang K, Zeng Q, Feng Y, Ke Q, An Q, Qin LJ, Cui Y, Guo Y, Zhao D, Peng Y, Tian D, Xia K, Chen Y, Ni B, Wang J, Zhu X, Wei L, Liu Y, Xiang P, Liu JY, Xue Z, Fan G
Citation:
Dev Dyn. 2021 Jan 15. doi: 10.1002/dvdy.295. Online ahead of print
Abstract:
Genetic programs underlying preimplantation development and early lineage segregation are highly conserved across mammals. It...
Organism or Cell Type:
cynomolgus monkey embryo
Citation Extract:
Hu Y, Huang K, Zeng Q, Feng Y, Ke Q, An Q, Qin LJ, Cui Y, Guo Y, Zhao D, Peng Y, Tian D, Xia K, Chen Y, Ni B, Wang J, Zhu X, Wei L, Liu Y, Xiang P, Liu JY, Xue Z, Fan G. Single-cell analysis of non-human primate preimplantation development in comparison to humans and mice. Dev Dyn. 2021 Jan 15. doi: 10.1002/dvdy.295. Online ahead of print.

Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition

Authors:
Palframan MJ, Alharthy RD, Powalowska PK, Hayes CJ
Citation:
Org Biomol Chem. 2016;14(11):3112-3119. doi:10.1039/C6OB00007J
Abstract:
Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide–alkyne...
Citation Extract:
Palframan MJ, Alharthy RD, Powalowska PK, Hayes CJ. Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition. Org Biomol Chem. 2016;14(11):3112-3119. doi:10.1039/C6OB00007J.

Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions

Authors:
Dries R, Lange A, Heiny S, Berghaus KI., Bastmeyer M, Bentrop J
Citation:
Front Cell Devel Biol. 2021;8:1579. doi:10.3389/fcell.2020.591011
Abstract:
The posterior lateral line system (pLLS) of aquatic animals comprises small clustered mechanosensory organs along the side of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dries R, Lange A, Heiny S, Berghaus KI., Bastmeyer M, Bentrop J. Cell Proliferation and Collective Cell Migration During Zebrafish Lateral Line System Development Are Regulated by Ncam/Fgf-Receptor Interactions. Front Cell Devel Biol. 2021;8:1579. doi:10.3389/fcell.2020.591011 .

Development of antisense-mediated myostatin knockdown for the treatment of insulin resistance

Authors:
Eilers W, Cleasby M, Foster K
Citation:
Sci Rep. 2021;11:1604. doi:10.1038/s41598-021-81222-7
Abstract:
Myostatin is a negative regulator of muscle mass and its inhibition represents a promising strategy for the treatment of muscle...
Delivery Method:
intramuscular i.m. or intravenous i.v. injection
Organism or Cell Type:
mice C57/Bl6
Citation Extract:
Eilers W, Cleasby M, Foster K. Development of antisense-mediated myostatin knockdown for the treatment of insulin resistance. Sci Rep. 2021;11:1604. doi:10.1038/s41598-021-81222-7.

Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model

Authors:
Helal M, Yan C, Gong Z
Citation:
Sci Rep. 2021;11:1372. doi:10.1038/s41598-020-80621-6
Abstract:
It has been well known that tumor progression is dependent on secreted factors not only from tumor cells but also from other...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Helal M, Yan C, Gong Z. Stimulation of hepatocarcinogenesis by activated cholangiocytes via Il17a/f1 pathway in kras transgenic zebrafish model. Sci Rep. 2021;11:1372. doi:10.1038/s41598-020-80621-6.

Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo

Authors:
Moustafa DA, Wu AW, Zamora D, Daly SM, Sturge CR, Pybus C, Geller BL, Goldberg JB, Greenberg DE
Citation:
mBio. 2021;12(1):e02411-20. doi:10.1128/mBio.02411-20
Abstract:
Most antimicrobials currently in the clinical pipeline are modifications of existing classes of antibiotics and are considered...
Delivery Method:
peptide-linked
Organism or Cell Type:
Pseudomonas aeruginosa as biofilm or murine pneumonial infection
Citation Extract:
Moustafa DA, Wu AW, Zamora D, Daly SM, Sturge CR, Pybus C, Geller BL, Goldberg JB, Greenberg DE. Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa In Vitro and In Vivo. mBio. 2021;12(1):e02411-20. doi:10.1128/mBio.02411-20.

Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord

Authors:
Danesin C, Darche-Gabinaud R, Escalas N, Bouguetoch V, Cochard P, Al Oustah A, Ohayon D, Glise B, Soula C
Citation:
Sci Rep. 2021;11:118 doi:10.1038/s41598-020-80455-2
Abstract:
Sulf2a belongs to the Sulf family of extracellular sulfatases which selectively remove 6-O-sulfate groups from heparan sulfates...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Danesin C, Darche-Gabinaud R, Escalas N, Bouguetoch V, Cochard P, Al Oustah A, Ohayon D, Glise B, Soula C. Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord. Sci Rep. 2021;11:118 doi:10.1038/s41598-020-80455-2.

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