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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12519 scientific papers returned from the database with the search filters currently being used below.

Endosomal microautophagy is activated by specific cellular stresses in trout hepatocytes

Authors:
Vélez EJ, Véron V, Gouis J, Reji S, Dias K, Herpin A, Beaumatin F, Seiliez I
Citation:
Sci Rep 15, 39347 (2025). https://doi.org/10.1038/s41598-025-23022-x
Epub:
Not Epub
Abstract:
Endosomal microautophagy (eMI) is a recently discovered autophagic process where cytosolic proteins are selectively captured in...
Link:
https://www.nature.com/articles/s41598-025-23022-x
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: Stably transfected RTH-149 cells expressing mutated KFERQ motifs or KFERQ-PA-mCherry1
Citation Extract:
Vélez EJ, Véron V, Gouis J, Reji S, Dias K, Herpin A, Beaumatin F, Seiliez I. Endosomal microautophagy is activated by specific cellular stresses in trout hepatocytes. Sci Rep 15, 39347 (2025). https://doi.org/10.1038/s41598-025-23022-x.

Foxi2 and Sox3 are master transcription regulators that control ectoderm germ layer specification in Xenopus

Authors:
Hendrickson CL, Blitz IL, Hussein A, Paraiso KD, Cho JS, Klymkowsky MW, Kofron MJ, Cho KWY
Citation:
PLoS Biol. 2025 Nov 4;23(11):e3003476. doi: 10.1371/journal.pbio.3003476. Epub ahead of print. PMID: 41187170
Epub:
Not Epub
Abstract:
Germ layer specification represents a critical transition where pluripotent cells acquire lineage-specific identities. We...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003476
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Hendrickson CL, Blitz IL, Hussein A, Paraiso KD, Cho JS, Klymkowsky MW, Kofron MJ, Cho KWY. Foxi2 and Sox3 are master transcription regulators that control ectoderm germ layer specification in Xenopus. PLoS Biol. 2025 Nov 4;23(11):e3003476. doi: 10.1371/journal.pbio.3003476. Epub ahead of print. PMID: 41187170.

Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation

Authors:
Klein R, Onyuru J, Centa JL, Viera EM, Putnam CD, Hoffman HM, Hastings ML
Citation:
Nucleic Acids Res. 2025 Oct 28;53(20):gkaf1116. doi: 10.1093/nar/gkaf1116. PMID: 41206040; PMCID: PMC12596483
Epub:
Not Epub
Abstract:
Inflammation has an essential role in healing. However, over-active inflammation disrupts normal cellular functions and can be...
Link:
https://academic.oup.com/nar/article/53/20/gkaf1116/8316289
Delivery Method:
Endo-Porter for cells; intraperitoneal (i.p.) & subcutaneous (s.c.) injection for mice
Organism or Cell Type:
cell culture: THP-1 & immortalized murine bone marrow-derived macrophages (iBMDMs); mice: C57BL/6 & Nlrp3D301N/+ LysMCre+
Citation Extract:
Klein R, Onyuru J, Centa JL, Viera EM, Putnam CD, Hoffman HM, Hastings ML. Modulating NLRP3 splicing with antisense oligonucleotides to control pathological inflammation. Nucleic Acids Res. 2025 Oct 28;53(20):gkaf1116. doi: 10.1093/nar/gkaf1116. PMID: 41206040; PMCID: PMC12596483.

Epigenetic regulation of cilia stability and kidney development by the chromatin remodeling SWI/SNF complex in zebrafish

Authors:
Cheng X, Zhu Q, Ma S, Peng X, Huang G, Liu G, Zhang W, Zhang Y, Jiang C, Qiu A, Cao Y
Citation:
Journal of Genetics and Genomiccs. 2025. ISSN 1673-8527, https://doi.org/10.1016/j.jgg.2025.11.001
Epub:
Not Epub
Abstract:
Cilia are vital subcellular organelles whose assembly is regulated by master transcription factors, such as Foxj1 and Rfx....
Link:
https://www.sciencedirect.com/science/article/pii/S1673852725002905
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cheng X, Zhu Q, Ma S, Peng X, Huang G, Liu G, Zhang W, Zhang Y, Jiang C, Qiu A, Cao Y. Epigenetic regulation of cilia stability and kidney development by the chromatin remodeling SWI/SNF complex in zebrafish. Journal of Genetics and Genomiccs. 2025. ISSN 1673-8527, https://doi.org/10.1016/j.jgg.2025.11.001.

Multi-scale discovery of herbacetin as a macrophage-targeted SGK1-STAT1 signaling inhibitor alleviating lung inflammation and barrier dysfunction

Authors:
Ge X, Yu S, Wu S, Zhang S, Zhao R, Zhao L
Citation:
Phytomedicine, Volume 148, 2025, 157489, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2025.157489
Epub:
Not Epub
Abstract:
Introduction: Acute lung injury (ALI) is characterized by dysregulated macrophage-epithelial interactions, leading to barrier...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0944711325011262
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ge X, Yu S, Wu S, Zhang S, Zhao R, Zhao L. Multi-scale discovery of herbacetin as a macrophage-targeted SGK1-STAT1 signaling inhibitor alleviating lung inflammation and barrier dysfunction. Phytomedicine, Volume 148, 2025, 157489, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2025.157489.

Interplay of ECM organization, ROCK signaling, and cell polarity drives mesothelium formation and lung growth

Authors:
Liu X, Lin B, Li P, Cai Z, Cao W, Yang W, Zeng J, Li L, Zhou Y, Huang D, Stainier DYR, Ran P, Yin W
Citation:
Nat Commun. 2025 Oct 30;16(1):9610. doi: 10.1038/s41467-025-64597-3. PMID: 41168230; PMCID: PMC12575704
Epub:
Not Epub
Abstract:
The mechanisms regulating organ size remain poorly understood. Here, we show that FREM2 is a critical modulator of lung size....
Link:
https://www.nature.com/articles/s41467-025-64597-3
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Isolated tracheas and lungs from C57BL/6J mouse embryos
Citation Extract:
Liu X, Lin B, Li P, Cai Z, Cao W, Yang W, Zeng J, Li L, Zhou Y, Huang D, Stainier DYR, Ran P, Yin W. Interplay of ECM organization, ROCK signaling, and cell polarity drives mesothelium formation and lung growth. Nat Commun. 2025 Oct 30;16(1):9610. doi: 10.1038/s41467-025-64597-3. PMID: 41168230; PMCID: PMC12575704.

Silencing of mitochondrial gene expression using polymorpholino chimeras

Authors:
Dahal D
Citation:
Nat Rev Mol Cell Biol. 2025 Nov 3. doi: 10.1038/s41580-025-00923-3. Epub ahead of print. PMID: 41184643
Epub:
Not Epub
Abstract:
The human mitochondrial genome encodes 13 essential protein components of the oxidative phosphorylation complexes responsible...
Link:
https://www.nature.com/articles/s41580-025-00923-3
Citation Extract:
Dahal D. Silencing of mitochondrial gene expression using polymorpholino chimeras. Nat Rev Mol Cell Biol. 2025 Nov 3. doi: 10.1038/s41580-025-00923-3. Epub ahead of print. PMID: 41184643.

Irg1l regulates neuromast size via metabolic reprogramming to promote supporting cell proliferation

Authors:
Wang X, Shi R, Xiang Y, Gao Y, Wan G, Sun S, Liu D
Citation:
J Cell Biol. 2025 Dec 1;224(12):e202501122. doi: 10.1083/jcb.202501122. Epub 2025 Oct 28. PMID: 41147954
Epub:
Not Epub
Abstract:
One of the most basic principles in embryonic development is ensuring the proper size of tissues and organs to meet functional...
Link:
https://rupress.org/jcb/article-abstract/224/12/e202501122/278418/Irg1l-regulates-neuromast-size-via-metabolic
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang X, Shi R, Xiang Y, Gao Y, Wan G, Sun S, Liu D. Irg1l regulates neuromast size via metabolic reprogramming to promote supporting cell proliferation. J Cell Biol. 2025 Dec 1;224(12):e202501122. doi: 10.1083/jcb.202501122. Epub 2025 Oct 28. PMID: 41147954.

A steady-state pool of calcium-dependent actin is maintained by Homer and controls epithelial mechanosensation

Authors:
Matsuzawa K, Suzuki M, Cho Y, Fujinaga R, Ikenouchi J
Citation:
Proc Natl Acad Sci U S A. 2025 Oct 28;122(43):e2509784122. doi: 10.1073/pnas.2509784122. Epub 2025 Oct 24. PMID: 41134626
Epub:
Not Epub
Abstract:
Epithelial cells are inherently contractile and in homeostasis, tissue integrity is maintained by balancing the uneven...
Link:
https://www.pnas.org/doi/10.1073/pnas.2509784122
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Matsuzawa K, Suzuki M, Cho Y, Fujinaga R, Ikenouchi J. A steady-state pool of calcium-dependent actin is maintained by Homer and controls epithelial mechanosensation. Proc Natl Acad Sci U S A. 2025 Oct 28;122(43):e2509784122. doi: 10.1073/pnas.2509784122. Epub 2025 Oct 24. PMID: 41134626.

Targeted α-Synuclein mRNA Degradation by PMO-Based RNA-Degrading Chimeras

Authors:
Wang N, Hegde S, Tang Z, Liu H, Feng G, Niu L, Li H, Gadhave K, Kumbhar R, Zhang S, Dawson TM, Pantelyat A, Rosenthal LS, Ying M, Mao X, Wang J
Citation:
bioRxiv [Preprint] 2025.10.17.683180; doi: https://doi.org/10.1101/2025.10.17.683180
Epub:
Not Epub
Abstract:
α-Synucleinopathies are devastating neurodegenerative diseases characterized by pathological accumulation of a neuronal protein...
Link:
https://www.biorxiv.org/content/10.1101/2025.10.17.683180v1.full
Delivery Method:
cells: Endo-Porter PEG; mice: stereotaxic injection
Organism or Cell Type:
HEK293T cells, primary cortical neurons from humanized SNCA PAC-Tg (SNCAWT) mice, human iPSC neurons; humanized SNCA mice
Citation Extract:
Wang N, Hegde S, Tang Z, Liu H, Feng G, Niu L, Li H, Gadhave K, Kumbhar R, Zhang S, Dawson TM, Pantelyat A, Rosenthal LS, Ying M, Mao X, Wang J. Targeted α-Synuclein mRNA Degradation by PMO-Based RNA-Degrading Chimeras. bioRxiv [Preprint] 2025.10.17.683180; doi: https://doi.org/10.1101/2025.10.17.683180.

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