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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9561 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Quiescent cells actively replenish CENP-A nucleosomes to maintain centromere identity and proliferative potential

Authors:
Swartz SZ, McKay LS, Su K-C, Padeganeh A, Paul S. Maddox PS, Knouse KA, Cheeseman IM.
Citation:
Dev Cell. 2019;[Epub ahead of print] doi:10.1016/j.devcel.2019.07.016
Abstract:
Centromeres provide a robust model for epigenetic inheritance as they are specified by sequence-independent mechanisms...
Delivery Method:
microinjection
Organism or Cell Type:
Patiria miniata (starfish)
Citation Extract:
Swartz SZ, McKay LS, Su K-C, Padeganeh A, Paul S. Maddox PS, Knouse KA, Cheeseman IM.. Quiescent cells actively replenish CENP-A nucleosomes to maintain centromere identity and proliferative potential. Dev Cell. 2019;[Epub ahead of print] doi:10.1016/j.devcel.2019.07.016.

Donepezil modulates amyloid precursor protein endocytosis and reduction by up-regulation of SNX33 expression in primary cortical neurons

Authors:
Takada-Takatori Y, Nakagawa S, Kimata R, Nao Y, Mizukawa Y, Urushidani T, Izumi Y, Akaike A, Tsuchida K, Kume T
Citation:
Sci Rep. 2019;9:11922. doi:10.1038/s41598-019-47462-4
Abstract:
Donepezil, a therapeutic drug for Alzheimer’s disease, ameliorates cognitive dysfunction through selective inhibition of...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: rat primary cortical neurons
Citation Extract:
Takada-Takatori Y, Nakagawa S, Kimata R, Nao Y, Mizukawa Y, Urushidani T, Izumi Y, Akaike A, Tsuchida K, Kume T. Donepezil modulates amyloid precursor protein endocytosis and reduction by up-regulation of SNX33 expression in primary cortical neurons. Sci Rep. 2019;9:11922. doi:10.1038/s41598-019-47462-4.

A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling

Authors:
Frikstad K-AM, Molinari E, Thoresen M, Roepman R, Sayer JA, Patzke S
Citation:
Cell Rep. 2019;28(7):1907-22. doi:10.1016/j.celrep.2019.07.025
Abstract:
CEP104 is an evolutionarily conserved centrosomal and ciliary tip protein. CEP104 loss-of-function mutations are reported in...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Frikstad K-AM, Molinari E, Thoresen M, Roepman R, Sayer JA, Patzke S. A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Cell Rep. 2019;28(7):1907-22. doi:10.1016/j.celrep.2019.07.025.

Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development

Authors:
Gong J, Gaitanos TN, Luu O, Huang Y, Gaitanos L, Lindner J, Winklbauer R, Rüdiger Klein R
Citation:
J Cell Biol. 2019;]Epub ahead of print] doi:10.1083/jcb.201901032
Abstract:
Trogocytosis, in which cells nibble away parts of neighboring cells, is an intercellular cannibalism process conserved from...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Gong J, Gaitanos TN, Luu O, Huang Y, Gaitanos L, Lindner J, Winklbauer R, Rüdiger Klein R. Gulp1 controls Eph/ephrin trogocytosis and is important for cell rearrangements during development. J Cell Biol. 2019;]Epub ahead of print] doi:10.1083/jcb.201901032.

In Vitro Validation of Phosphorodiamidate Morpholino Oligomers

Authors:
Aung-Htut MT, McIntosh CS, West KA, Fletcher S, Wilton SD
Citation:
Molecules. 2019;24(6):2922 doi:0.3390/molecules24162922
Abstract:
One of the crucial aspects of screening antisense oligonucleotides destined for therapeutic application is confidence that the...
Delivery Method:
electroporation Lipofectin Lipofectamine Endo-Porter
Organism or Cell Type:
cell culture: human dermal fibroblasts, human myoblasts
Citation Extract:
Aung-Htut MT, McIntosh CS, West KA, Fletcher S, Wilton SD. In Vitro Validation of Phosphorodiamidate Morpholino Oligomers. Molecules. 2019;24(6):2922 doi:0.3390/molecules24162922.

U1 snRNP regulates cancer cell migration and invasion

Authors:
Oh J-M, Venters CC, Di C, Pinto AM, Wan L, Younis I, Cai Z, Arai C, So BR, Dreyfuss G
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/730515
Abstract:
Stimulated cells and cancer cells have widespread shortening of mRNA 3′-utranslated regions (3′UTRs) and switches to shorter...
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: HeLa, A549, MCF-7 and MB-231
Citation Extract:
Oh J-M, Venters CC, Di C, Pinto AM, Wan L, Younis I, Cai Z, Arai C, So BR, Dreyfuss G. U1 snRNP regulates cancer cell migration and invasion. bioRxiv. 2019;[preprint] doi:10.1101/730515 .

De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies

Authors:
Holt RJ, Young RM, Crespo B, Ceroni F, Curry CJ, Bellacchio E, Bax DA, Ciolfi A, Simon M, Fagerberg CR, van Binsbergen E, De Luca A, Memo L, Dobyns WB, Mohammed AA, Clokie SJH, Seco CZ, Jiang Y-H, Sørensen KP, Andersen H, Sullivan J, Powis Z, Chassevent A, Smith-Hicks C, Petrovski S, Antoniadi T, Shashi V, Gelb BD, Wilson SW, Gerrelli D, Tartaglia M, Chassaing N, Calvas P, Ragge NK
Citation:
Am J Hum Genet. 2019;[Epub ahead of print] doi:10.1016/j.ajhg.2019.07.005
Abstract:
The identification of genetic variants implicated in human developmental disorders has been revolutionized by second-generation...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Holt RJ, Young RM, Crespo B, Ceroni F, Curry CJ, Bellacchio E, Bax DA, Ciolfi A, Simon M, Fagerberg CR, van Binsbergen E, De Luca A, Memo L, Dobyns WB, Mohammed AA, Clokie SJH, Seco CZ, Jiang Y-H, Sørensen KP, Andersen H, Sullivan J, Powis Z, Chassevent A, Smith-Hicks C, Petrovski S, Antoniadi T, Shashi V, Gelb BD, Wilson SW, Gerrelli D, Tartaglia M, Chassaing N, Calvas P, Ragge NK. De Novo Missense Variants in FBXW11 Cause Diverse Developmental Phenotypes Including Brain, Eye, and Digit Anomalies. Am J Hum Genet. 2019;[Epub ahead of print] doi:10.1016/j.ajhg.2019.07.005.

Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium

Authors:
Bonkhofer F, Rispoli R, Pinheiro P, Krecsmarik M, Schneider-Swales J, Tsang IHC, de Bruijn M, Monteiro R, Peterkin T, Patient R
Citation:
Nat Comm. 2019;10(1):3577. doi:10.1038/s41467-019-11423-2
Abstract:
Haematopoietic stem cells are generated from the haemogenic endothelium (HE) located in the floor of the dorsal aorta (DA)....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bonkhofer F, Rispoli R, Pinheiro P, Krecsmarik M, Schneider-Swales J, Tsang IHC, de Bruijn M, Monteiro R, Peterkin T, Patient R. Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium. Nat Comm. 2019;10(1):3577. doi:10.1038/s41467-019-11423-2.

TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes

Authors:
Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk H-D, Böttcher-Friebertshäuser E
Citation:
J Virol. 2019;[Epub ahead of print] doi:10.1128/JVI.00649-19
Abstract:
Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is essential for virus infectivity and spread. We...
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: primary human bronchial epithelial cells (HBEC), primary type II alveolar epithelial cells (AECII) and Calu-3 cells
Citation Extract:
Limburg H, Harbig A, Bestle D, Stein DA, Moulton HM, Jaeger J, Janga H, Hardes K, Koepke J, Schulte L, Koczulla AR, Schmeck B, Klenk H-D, Böttcher-Friebertshäuser E. TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes. J Virol. 2019;[Epub ahead of print] doi:10.1128/JVI.00649-19.

Zebrafish Dynamin is required for maintenance of enveloping layer integrity and the progression of epiboly

Authors:
Lepage SE, Tada M, Bruce AE
Citation:
Dev Biol. 2014 Jan 1;385(1):52-66. doi: 10.1016/j.ydbio.2013.10.015. Epub 2013 Oct 24
Abstract:
Epiboly, the first morphogenetic cell movement that occurs in the zebrafish embryo, is the process by which the blastoderm...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lepage SE, Tada M, Bruce AE. Zebrafish Dynamin is required for maintenance of enveloping layer integrity and the progression of epiboly. Dev Biol. 2014 Jan 1;385(1):52-66. doi: 10.1016/j.ydbio.2013.10.015. Epub 2013 Oct 24.

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