You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11058 scientific papers returned from the database with the search filters currently being used below.

Carbonic anhydrase inhibitor induces otic hair cell apoptosis via an intrinsic pathway and ER stress in zebrafish larvae

Authors:
Matsumoto H, Miyagi H, Nakamura N, Shiga Y, Ohta T, Fujiwara S, Tsuzuki M
Citation:
Toxicol Rep. 2021;[Epub ahead of print] doi:10.1016/j.toxrep.2021.11.018
Epub:
Not Epub
Abstract:
Carbonic anhydrase (CA) catalyzes reversible hydration of CO2 to HCO3− to mediate pH and ion homeostasis. Some chemical...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Matsumoto H, Miyagi H, Nakamura N, Shiga Y, Ohta T, Fujiwara S, Tsuzuki M. Carbonic anhydrase inhibitor induces otic hair cell apoptosis via an intrinsic pathway and ER stress in zebrafish larvae. Toxicol Rep. 2021;[Epub ahead of print] doi:10.1016/j.toxrep.2021.11.018.

Vertebrate hemicentin-1 interacts physically and genetically with nidogen-2

Authors:
Zhang J-L, Richetti S, Ramezani T, Welcker D, Lütke S, Pogoda H-M, Hatzold J, Zaucke F, Keene DR, Bloch W, Sengle G, Hammerschmidt M
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.11.24.469833
Epub:
Not Epub
Abstract:
Hemicentins are large proteins of the extracellular matrix that belong to the fibulin family and play pivotal roles during...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang J-L, Richetti S, Ramezani T, Welcker D, Lütke S, Pogoda H-M, Hatzold J, Zaucke F, Keene DR, Bloch W, Sengle G, Hammerschmidt M. Vertebrate hemicentin-1 interacts physically and genetically with nidogen-2. bioRxiv. 2021;[preprint] doi:10.1101/2021.11.24.469833.

Somatic uniparental disomy mitigates the most damaging EFL1 allele combination in Shwachman-Diamond syndrome

Authors:
Lee S, Shin CH, Lee J, Jeong SD, Hong CR, Kim J-D, Kim A-R, Park B, Son SJ, Kokhan O, Yoo T, Ko JS, Sohn YB, Kim O-H, Ko JM, Cho T-J, Wright NT, Seong JK, Jin S-W, Kang HJ, Kim HH, Choi M.
Citation:
Blood. 2021;138(21):217-28. doi:10.1182/blood.2021010913
Epub:
Not Epub
Abstract:
Shwachman-Diamond syndrome (SDS; OMIM #260400) is caused by variants in SBDS (Shwachman-Bodian-Diamond syndrome gene), which...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lee S, Shin CH, Lee J, Jeong SD, Hong CR, Kim J-D, Kim A-R, Park B, Son SJ, Kokhan O, Yoo T, Ko JS, Sohn YB, Kim O-H, Ko JM, Cho T-J, Wright NT, Seong JK, Jin S-W, Kang HJ, Kim HH, Choi M.. Somatic uniparental disomy mitigates the most damaging EFL1 allele combination in Shwachman-Diamond syndrome. Blood. 2021;138(21):217-28. doi:10.1182/blood.2021010913.

Systematic mapping of rRNA 2’-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in Xenopus laevis

Authors:
Delhermite J, Tafforeau L, Sharma S, Marchand V, Wacheul L, Lattuca R, Desiderio S, Motorin Y, Bellefroid E, Lafontaine DLJ
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.11.25.469989
Epub:
Not Epub
Abstract:
Ribosomes are essential nanomachines responsible for protein production. Although ribosomes are present in every living cell,...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Delhermite J, Tafforeau L, Sharma S, Marchand V, Wacheul L, Lattuca R, Desiderio S, Motorin Y, Bellefroid E, Lafontaine DLJ. Systematic mapping of rRNA 2’-O methylation during frog development and involvement of the methyltransferase Fibrillarin in eye and craniofacial development in Xenopus laevis. bioRxiv. 2021;[preprint] doi:10.1101/2021.11.25.469989.

Transient grb10a Knockdown Permanently Alters Growth, Cardiometabolic Phenotype and the Transcriptome in Danio rerio

Authors:
Evans BL, Garner T, De Leonibus C, Wearing OH, Shiels HA, Hurlstone AFL, Clayton PE, Stevens A
Citation:
bioRxiv. 2020;[preprint] doi:/10.1101/2020.12.06.413633
Epub:
Not Epub
Abstract:
Embryonic growth trajectory is a risk factor for chronic metabolic and cardiovascular disorder. Grb10 is a negative regulator...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Evans BL, Garner T, De Leonibus C, Wearing OH, Shiels HA, Hurlstone AFL, Clayton PE, Stevens A. Transient grb10a Knockdown Permanently Alters Growth, Cardiometabolic Phenotype and the Transcriptome in Danio rerio. bioRxiv. 2020;[preprint] doi:/10.1101/2020.12.06.413633 .

ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis

Authors:
Min KD, Asakura M, Shirai M, Yamazaki S, Ito S, Fu HY, Asanuma H, Asano Y, Minamino T, Takashima S, Kitakaze M
Citation:
Sci Rep. 2021 Nov 29;11(1):23056. doi: 10.1038/s41598-021-02390-0
Epub:
Not Epub
Abstract:
Cardiogenesis requires the orchestrated spatiotemporal tuning of BMP signalling upon the balance between induction and counter-...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Min KD, Asakura M, Shirai M, Yamazaki S, Ito S, Fu HY, Asanuma H, Asano Y, Minamino T, Takashima S, Kitakaze M. ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis. Sci Rep. 2021 Nov 29;11(1):23056. doi: 10.1038/s41598-021-02390-0.

A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation

Authors:
Lu HY, Sertori R, Contreras AV, Hamer M, Messing M, Del Bel KL, Lopez-Rangel E, Chan ES, Rehmus W, Milner JD, McNagny KM, Lehman A, Wiest DL, Turvey SE
Citation:
Front Immunol. 2021;12:4895. doi:10.3389/fimmu.2021.788278
Epub:
Not Epub
Abstract:
B-cell lymphoma/leukemia 11B (BCL11B) is a C2H2 zinc finger transcription factor that is critically important for regulating...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lu HY, Sertori R, Contreras AV, Hamer M, Messing M, Del Bel KL, Lopez-Rangel E, Chan ES, Rehmus W, Milner JD, McNagny KM, Lehman A, Wiest DL, Turvey SE. A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation. Front Immunol. 2021;12:4895. doi:10.3389/fimmu.2021.788278 .

LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole

Authors:
Shen X-L, Yuan J-F, Qin X-E, Song G-P, Hu H-B, Tu H-Q, Song Z-Q, Li P-Y, Xu Y-L, Sen Li, Jian X-X, Li J-N, He C-Y, Yu X-P, Liang L-Y, Wu M, Han Q-Y, Wang K, Li A-L, Zhou T, Zhang Y-C, Wang N, Li H-Y
Citation:
J Cell Biol. 2021;221(1):e202105092. doi:10.1083/jcb.202105092
Epub:
Not Epub
Abstract:
Primary cilia transduce diverse signals in embryonic development and adult tissues. Defective ciliogenesis results in a series...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shen X-L, Yuan J-F, Qin X-E, Song G-P, Hu H-B, Tu H-Q, Song Z-Q, Li P-Y, Xu Y-L, Sen Li, Jian X-X, Li J-N, He C-Y, Yu X-P, Liang L-Y, Wu M, Han Q-Y, Wang K, Li A-L, Zhou T, Zhang Y-C, Wang N, Li H-Y. LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole. J Cell Biol. 2021;221(1):e202105092. doi:10.1083/jcb.202105092.

Identification of ZBTB26 as a Novel Risk Factor for Congenital Hypothyroidism

Authors:
Vick P, Eberle B, Choukair D, Weiss B, Roeth R, Schneider I, Paramasivam N, Bettendorf M, Rappold GA
Citation:
Genes. 2021;12(12):1862. doi:10.3390/genes12121862
Epub:
Not Epub
Abstract:
Congenital primary hypothyroidism (CH; OMIM 218700) is characterized by an impaired thyroid development, or dyshormonogenesis,...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Vick P, Eberle B, Choukair D, Weiss B, Roeth R, Schneider I, Paramasivam N, Bettendorf M, Rappold GA. Identification of ZBTB26 as a Novel Risk Factor for Congenital Hypothyroidism. Genes. 2021;12(12):1862. doi:10.3390/genes12121862.

Modulation of PKM1/2 levels by steric blocking morpholinos alters the metabolic and pluripotent state of murine pluripotent stem cells

Authors:
Dierolf JG, Hunter HLM, Watson AJ, Betts DH
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.11.23.469697
Epub:
Not Epub
Abstract:
Cellular metabolism plays both an active and passive role in embryonic development, pluripotency, and cell-fate decisions....
Delivery Method:
scrape loading
Organism or Cell Type:
cell culture: murine embryonic stem cells
Citation Extract:
Dierolf JG, Hunter HLM, Watson AJ, Betts DH. Modulation of PKM1/2 levels by steric blocking morpholinos alters the metabolic and pluripotent state of murine pluripotent stem cells. bioRxiv. 2021;[preprint] doi:10.1101/2021.11.23.469697.

Pages