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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12221 scientific papers returned from the database with the search filters currently being used below.
There are 12221 scientific papers returned from the database with the search filters currently being used below.
The evolutionary modifications of a GoLoco motif in the AGS protein facilitate micromere formation in the sea urchin embryo
Citation:
bioRxiv [Preprint]. 2024 Jul 2:2024.06.30.601440. doi: 10.1101/2024.06.30.601440. PMID: 39005292; PMCID: PMC11244941 Epub:
Not Epub Abstract:
The evolutionary introduction of asymmetric cell division (ACD) into the developmental program facilitates the formation of a... Delivery Method:
microinjection Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin), Eucidaris tribuloides (sea urchin), Patiria miniata (sea star) Citation Extract: Emura N, Wavreil FDM, Fries A, Yajima M. The evolutionary modifications of a GoLoco motif in the AGS protein facilitate micromere formation in the sea urchin embryo. bioRxiv [Preprint]. 2024 Jul 2:2024.06.30.601440. doi: 10.1101/2024.06.30.601440. PMID: 39005292; PMCID: PMC11244941. |
Zonated Wnt/β-catenin signal-activated cardiomyocytes at the atrioventricular canal promote coronary vessel formation in zebrafish
Citation:
Dev Cell. 2024 Oct 8:S1534-5807(24)00540-9. doi: 10.1016/j.devcel.2024.09.012. Epub ahead of print. PMID: 39395410 Epub:
Not Epub Abstract:
Cells functioning at a specific zone by clustering according to gene expression are recognized as zonated cells. Here, we... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chiba A, Yamamoto T, Fukui H, Fukumoto M, Shirai M, Nakajima H, Mochizuki N. Zonated Wnt/β-catenin signal-activated cardiomyocytes at the atrioventricular canal promote coronary vessel formation in zebrafish. Dev Cell. 2024 Oct 8:S1534-5807(24)00540-9. doi: 10.1016/j.devcel.2024.09.012. Epub ahead of print. PMID: 39395410. |
A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass
Citation:
Bone Res. 2024 Oct 16;12(1):60. doi: 10.1038/s41413-024-00364-2. PMID: 39414788 Epub:
Not Epub Abstract:
Cellular communication network factor 2 (CCN2) is a secreted extracellular matrix-associated protein, and its aberrantly... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Li S, Shao R, Li S, Zhao J, Deng Q, Li P, Wei Z, Xu S, Chen L, Li B, Zou W, Zhang Z. A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass. Bone Res. 2024 Oct 16;12(1):60. doi: 10.1038/s41413-024-00364-2. PMID: 39414788. |
Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model
Citation:
Neuron. 2024 Oct 9;112(19):3278-3294.e7. doi: 10.1016/j.neuron.2024.07.013. Epub 2024 Aug 8. PMID: 39121859 Epub:
Not Epub Abstract:
Primary familial brain calcification (PFBC) is a genetic neurological disease, yet no effective treatment is currently... Delivery Method:
intracerebroventricular (i.c.v.) for mice; Endo-Porter for cells Organism or Cell Type:
cell culture: Neuro-2A; mice: SLC20A2-KI Citation Extract: Zhao M, Cheng X, Chen L, Zeng YH, Lin KJ, Li YL, Zheng ZH, Huang XJ, Zuo DD, Guo XX, Guo J, He D, Liu Y, Lin Y, Wang C, Lv WQ, Su HZ, Yao XP, Ye ZL, Chen XH, Lu YQ, Huang CW, Yang G, Zhang YX, Lin MT, Wang N, Xiong ZQ, Chen WJ. Antisense oligonucleotides enhance SLC20A2 expression and suppress brain calcification in a humanized mouse model. Neuron. 2024 Oct 9;112(19):3278-3294.e7. doi: 10.1016/j.neuron.2024.07.013. Epub 2024 Aug 8. PMID: 39121859. |
An Accurate and Fast 31P qNMR Assay Method for Oligonucleotide Therapeutics
Citation:
Anal Chem. 2024 Oct 11. doi: 10.1021/acs.analchem.4c03693. Online ahead of print. PMID: 39392205 Epub:
Not Epub Abstract:
Chemically modified nucleic acid molecules have been developed as oligonucleotide therapeutics, and its assay is critical in... Delivery Method:
intravenous (i.v.) infusion Organism or Cell Type:
human Citation Extract: Li J, Chen F, Zhang D, Wang Y, Kozak D, Chen K. An Accurate and Fast 31P qNMR Assay Method for Oligonucleotide Therapeutics. Anal Chem. 2024 Oct 11. doi: 10.1021/acs.analchem.4c03693. Online ahead of print. PMID: 39392205. |
ATM1, an essential conserved transporter in Apicomplexa, bridges mitochondrial and cytosolic [Fe-S] biogenesis
Citation:
PLoS Pathog. 2024 Sep 30;20(9):e1012593 Epub:
Not Epub Abstract:
The Apicomplexa phylum encompasses numerous obligate intracellular parasites, some associated with severe implications for... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
Plasmodium falciparum Citation Extract: Shrivastava D, Abboud E, Ramchandra JP, Jha A, Marq JB, Chaurasia A, Mitra K, Sadik M, Siddiqi MI, Soldati-Favre D, Kloehn J, Habib S. ATM1, an essential conserved transporter in Apicomplexa, bridges mitochondrial and cytosolic [Fe-S] biogenesis. PLoS Pathog. 2024 Sep 30;20(9):e1012593. |
Spastin accumulation and motor neuron defects caused by a novel SPAST splice site mutation
Citation:
J Transl Med. 2024 Sep 27;22(1):872. doi: 10.1186/s12967-024-05669-8. PMID: 39334479; PMCID: PMC11429824 Epub:
Not Epub Abstract:
Background: Hereditary spastic paraplegia (HSP) is a rare genetically heterogeneous neurodegenerative disorder. The most common... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Luo M, Wang Y, Liang J, Wan X. Spastin accumulation and motor neuron defects caused by a novel SPAST splice site mutation. J Transl Med. 2024 Sep 27;22(1):872. doi: 10.1186/s12967-024-05669-8. PMID: 39334479; PMCID: PMC11429824. |
RRAGD variants cause cardiac dysfunction in a zebrafish model
Citation:
Am J Physiol Heart Circ Physiol. 2024 Sep 27. doi: 10.1152/ajpheart.00705.2023. Epub ahead of print. PMID: 39331021 Epub:
Not Epub Abstract:
The Ras-related GTP-binding protein D (RRAGD) gene plays a crucial role in cellular processes. Recently, RRAGD variants found... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Adella A, Tengku F, Arjona FJ, Broekman S, de Vrieze E, van Wijk E, Hoenderop JGJ, de Baaij JHF. RRAGD variants cause cardiac dysfunction in a zebrafish model. Am J Physiol Heart Circ Physiol. 2024 Sep 27. doi: 10.1152/ajpheart.00705.2023. Epub ahead of print. PMID: 39331021. |
Safety and efficacy of viltolarsen in ambulatory and nonambulatory males with Duchenne muscular dystrophy
Citation:
Sci Rep. 2024 Oct 8;14(1):23488. doi: 10.1038/s41598-024-70783-y. PMID: 39379403 Epub:
Not Epub Abstract:
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease characterized by mutations in the dystrophin gene, causing... Delivery Method:
intravenous (i.v.) infusion Organism or Cell Type:
human Citation Extract: Harper AD, Topaloglu H, Mercuri E, Suslov V, Wu L, Ayanoglu CY, Tansey M, Previtera ML, Crozier RA, Magnus L, Clemens PR. Safety and efficacy of viltolarsen in ambulatory and nonambulatory males with Duchenne muscular dystrophy. Sci Rep. 2024 Oct 8;14(1):23488. doi: 10.1038/s41598-024-70783-y. PMID: 39379403. |
PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators
Citation:
Nucleic Acids Res. 2024 Oct 7:gkae862. doi: 10.1093/nar/gkae862. Epub ahead of print. PMID: 39373517 Epub:
Not Epub Abstract:
Spermatogenesis is a biological process within the testis that produces haploid spermatozoa for the continuity of species.... Delivery Method:
Endo-Porter Organism or Cell Type:
P22 or P35 mouse testes-derived Sertoli cells Citation Extract: Wang Y, Chembazhi UV, Yee D, Chen S, Ji J, Wang Y, Nguyen KL, Lin P, Ratti A, Hess RA, Qiao H, Ko C, Yang J, Kalsotra A, Mei W. PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators. Nucleic Acids Res. 2024 Oct 7:gkae862. doi: 10.1093/nar/gkae862. Epub ahead of print. PMID: 39373517. |