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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10798 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double-blind, placebo-controlled, dose-titration trial

Authors:
Wagner KR, Kuntz NL, Koenig E, East L, Upadhyay S, Han B, Shieh PB
Citation:
Muscle Nerve. 2021 Jun 8. doi: 10.1002/mus.27347. Online ahead of print
Epub:
Yes
Abstract:
Introduction/aims: Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene resulting in the absence of...
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Wagner KR, Kuntz NL, Koenig E, East L, Upadhyay S, Han B, Shieh PB. Safety, tolerability, and pharmacokinetics of casimersen in patients with Duchenne muscular dystrophy amenable to exon 45 skipping: A randomized, double-blind, placebo-controlled, dose-titration trial. Muscle Nerve. 2021 Jun 8. doi: 10.1002/mus.27347. Online ahead of print.

The gene regulatory system for specifying germ layers in early embryos of the simple chordate

Authors:
Tokuoka M, Maeda K, Kobayashi K, Mochizuki A, Satou Y
Citation:
Sci Adv. 2021;7(24):eabf8210 doi:10.1126/sciadv.abf8210
Epub:
Not Epub
Abstract:
In animal embryos, gene regulatory networks control the dynamics of gene expression in cells and coordinate such dynamics among...
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis
Citation Extract:
Tokuoka M, Maeda K, Kobayashi K, Mochizuki A, Satou Y. The gene regulatory system for specifying germ layers in early embryos of the simple chordate. Sci Adv. 2021;7(24):eabf8210 doi:10.1126/sciadv.abf8210.

Integrin intra-heterodimer affinity inversely correlates with integrin activatability

Authors:
Sun G, Guillon E, Holley SA
Citation:
Cell Rep. 2021;35(10):109230. doi:10.1016/j.celrep.2021.109230
Epub:
Not Epub
Abstract:
Integrins are heterodimeric cell surface receptors composed of an α and β subunit that mediate cell adhesion to extracellular...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sun G, Guillon E, Holley SA. Integrin intra-heterodimer affinity inversely correlates with integrin activatability. Cell Rep. 2021;35(10):109230. doi:10.1016/j.celrep.2021.109230.

eSkip-Finder: a machine learning-based web application and database to identify the optimal sequences of antisense oligonucleotides for exon skipping

Authors:
Chiba S, Lim KRQ, Sheri N, Anwar S, Erkut E, Shah MNA, Aslesh T, Woo S, Sheikh O, Maruyama R, Takano H, Kunitake K, Duddy W, Okuno Y, Aoki Y, Yokota T
Citation:
Nucl Acids Res. 2021;[Epub ahead of print] doi:10.1093/nar/gkab442
Epub:
Yes
Abstract:
Exon skipping using antisense oligonucleotides (ASOs) has recently proven to be a powerful tool for mRNA splicing modulation....
Organism or Cell Type:
cell culture: primary human myotubes
Citation Extract:
Chiba S, Lim KRQ, Sheri N, Anwar S, Erkut E, Shah MNA, Aslesh T, Woo S, Sheikh O, Maruyama R, Takano H, Kunitake K, Duddy W, Okuno Y, Aoki Y, Yokota T. eSkip-Finder: a machine learning-based web application and database to identify the optimal sequences of antisense oligonucleotides for exon skipping. Nucl Acids Res. 2021;[Epub ahead of print] doi:10.1093/nar/gkab442.

Early inflammation dysregulates neuronal circuit formation in vivo via upregulation of IL-1β

Authors:
Solek CM, Farooqi NAI, Brake N, Kesner P, Schohl A, Antel JP, Ruthazer ES
Citation:
J Neurosci. 2021 Jun 8:JN-RM-2159-20. doi: 10.1523/JNEUROSCI.2159-20.2021. Online ahead of print
Epub:
Yes
Abstract:
Neuro-immune interaction during development is strongly implicated in the pathogenesis of neurodevelopmental disorders, but the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Solek CM, Farooqi NAI, Brake N, Kesner P, Schohl A, Antel JP, Ruthazer ES. Early inflammation dysregulates neuronal circuit formation in vivo via upregulation of IL-1β. J Neurosci. 2021 Jun 8:JN-RM-2159-20. doi: 10.1523/JNEUROSCI.2159-20.2021. Online ahead of print.

Notch signaling via Hey1 and Id2b regulates Müller glia’s regenerative response to retinal injury

Authors:
Sahu A, Devi S, Jui J, Goldman D
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.435053
Epub:
Not Epub
Abstract:
Zebrafish Müller glia (MG) respond to retinal injury by suppressing Notch signaling and producing progenitors for retinal...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sahu A, Devi S, Jui J, Goldman D. Notch signaling via Hey1 and Id2b regulates Müller glia’s regenerative response to retinal injury. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.435053.

A precise regulation of presenilin expression is required for the sea urchin early development

Authors:
Bronchain O, Philippe-Caraty L, Anquetil V, Ciapa B
Citation:
J Cell Sci. 2021;jcs.258382. doi:10.1242/jcs.258382
Epub:
Not Epub
Abstract:
Presenilins or PSENs homologues are widely expressed across eukaryotes. Two PSEN are expressed in humans where they play a...
Organism or Cell Type:
sea urchin
Citation Extract:
Bronchain O, Philippe-Caraty L, Anquetil V, Ciapa B. A precise regulation of presenilin expression is required for the sea urchin early development. J Cell Sci. 2021;jcs.258382. doi:10.1242/jcs.258382.

Three-dimensional folding dynamics of the Xenopus tropicalis genome

Authors:
Niu L, Shen W, Shi Z, Tan Y, He N, Wan J, Sun J, Zhang Y, Huang Y, Wang W, Fang C, Li J, Zheng P, Cheung E, Chen Y, Li L, Hou C
Citation:
Nat Genet. 2021;[Epub ahead of print] doi:10.1038/s41588-021-00878-z
Epub:
Yes
Abstract:
Animal interphase chromosomes are organized into topologically associating domains (TADs). How TADs are formed is not fully...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Niu L, Shen W, Shi Z, Tan Y, He N, Wan J, Sun J, Zhang Y, Huang Y, Wang W, Fang C, Li J, Zheng P, Cheung E, Chen Y, Li L, Hou C. Three-dimensional folding dynamics of the Xenopus tropicalis genome. Nat Genet. 2021;[Epub ahead of print] doi:10.1038/s41588-021-00878-z.

Self-transfecting GMO-PMO and PMO-GMO chimeras enable gene silencing in vitro and in vivo zebrafish model and NANOG Inhibition Induce the Apoptosis in Breast and Prostate Cancer Cells

Authors:
Kundu J, Das U, Bose C, Bhadra J, Sinha S
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.06.04.447039
Epub:
Not Epub
Abstract:
Phosphorodiamidate Morpholino Oligonucleotides (PMOs)-based antisense reagents cannot enter inside cells by itself without the...
Delivery Method:
guanidinium-morpholino and Morpholino chimeras
Organism or Cell Type:
cell culture: Shh-Light 2, MCF7, PC-3, MDA MB-231, Shh-N; zebrafish
Citation Extract:
Kundu J, Das U, Bose C, Bhadra J, Sinha S. Self-transfecting GMO-PMO and PMO-GMO chimeras enable gene silencing in vitro and in vivo zebrafish model and NANOG Inhibition Induce the Apoptosis in Breast and Prostate Cancer Cells. bioRxiv. 2021;[preprint] doi:10.1101/2021.06.04.447039.

Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code

Authors:
Saha K, Fernandez MM, Biswas T, Joseph S, Ghosh G
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/292458
Epub:
Not Epub
Abstract:
The specific recognition of splice signals at or near exon-intron junctions is not explained by their weak conservation and...
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Saha K, Fernandez MM, Biswas T, Joseph S, Ghosh G. Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code. bioRxiv. 2021;[preprint] doi:10.1101/292458 .

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