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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12231 scientific papers returned from the database with the search filters currently being used below.
There are 12231 scientific papers returned from the database with the search filters currently being used below.
Neutral Backbone Modifications Enhance the Pharmacokinetics and Biodistribution of Antibody–Oligonucleotide Conjugates with High Drug-to-Antibody Ratios
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Citation:
J. Med. Chem. 2026; https://doi.org/10.1021/acs.jmedchem.6c00565 Epub:
Not Epub Abstract:
Antibody–oligonucleotide conjugates (AOCs) enable targeted delivery of small interfering RNAs (siRNAs) by coupling them to... Delivery Method:
RNA/PMO heteroduplex; Lipofectamine RNAiMAX for cells, intravenous (i.v) injection for mice Organism or Cell Type:
cell culture: SJCRH30; Hsd:ICR mice Citation Extract: Michael Cochran, Subbarao Nallagatla, Giuseppe Dello Iacono, Sami Abdulkadir, Danny Arias, Maryam Jordan, Hae Won Kwon, Arthur Levin, Michael Hood, Philip Kovach, Aidan Kim, Rob Burke, Barbora Malecova, Venkata Ramana Doppalapudi. Neutral Backbone Modifications Enhance the Pharmacokinetics and Biodistribution of Antibody–Oligonucleotide Conjugates with High Drug-to-Antibody Ratios. J. Med. Chem. 2026; https://doi.org/10.1021/acs.jmedchem.6c00565. |
Astrocyte activation mediates UV filter PBSA-induced impairment of neurogenesis via the rxrga/tsp-1 axis during a sensitive developmental window in early life stage zebrafish
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Citation:
Chem Biol Interact. 2026 Aug 7:112290 Epub:
Not Epub Abstract:
2-phenylbenzimidazole-5-sulfonic acid (PBSA), a widely used organic UV filter, is frequently detected in aquatic environments,... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yang Q, Tian L, Wang J, Qi C, Qian Z, Liu Y, Zhou Y, Chen X, Tao J. Astrocyte activation mediates UV filter PBSA-induced impairment of neurogenesis via the rxrga/tsp-1 axis during a sensitive developmental window in early life stage zebrafish. Chem Biol Interact. 2026 Aug 7:112290. |
Structural Optimization of Guanidinium-Linked Morpholino Phosphorodiamidate Morpholino Oligonucleotide Chimeras to Improve In Vitro Antisense Efficacy
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Citation:
Bioconjug Chem. 2026 Jul 21 Epub:
Not Epub Abstract:
Although phosphorodiamidate morpholino oligomers (PMOs) are potent and stable antisense agents, their neutral backbone limits... Delivery Method:
guanidinium-linked morpholino oligomers with PMOs Organism or Cell Type:
cell culture: MCF7 and HCT116 Citation Extract: Qasim M, Naaz S, Pratihar S, Sharma SN, Sinha S. Structural Optimization of Guanidinium-Linked Morpholino Phosphorodiamidate Morpholino Oligonucleotide Chimeras to Improve In Vitro Antisense Efficacy. Bioconjug Chem. 2026 Jul 21. |
A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts
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Citation:
Genes Cells. 2026 Jul;31(4):e70138 Epub:
Not Epub Abstract:
Nonsyndromic cleft lip with or without palate (nCL/P) is a common congenital anomaly with a complex genetic basis. Previous... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Uuganbayar U, Manojlovic Z, Ito N, Yamaguchi R, Ninomiya H, Shimada IS, Yamada C, Feigelson D, Schulz G, Auslander A, Rakotoarison S, Magee W 3rd, Hashimoto Y, Kato Y. A Combination of Variants in SEPTIN9 and MSX1 Genes Leads to the Formation of Orofacial Clefts. Genes Cells. 2026 Jul;31(4):e70138. |
Splice-altering TP53 missense mutations as drivers of dysfunction and targets for RNA-based therapy
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Citation:
Stem Cell Res Ther. 2026 Jul 13 Epub:
Not Epub Abstract:
TP53 missense mutations introduce single amino acid substitutions in the p53 protein, which can lead to diverse functional... Organism or Cell Type:
TP53 knock-in cell models Citation Extract: Chung SK, Jung HB, Baek SJ, Park SM, Kim J, Lee SY, Min B, Kang YK. Splice-altering TP53 missense mutations as drivers of dysfunction and targets for RNA-based therapy. Stem Cell Res Ther. 2026 Jul 13. |
Targeted α-synuclein mRNA degradation by PMO-based RNA-degrading chimeras
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Citation:
Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2526461123 Epub:
Not Epub Abstract:
α-Synucleinopathies are devastating neurodegenerative diseases characterized by pathological accumulation of a neuronal protein... Delivery Method:
PMO-based RNA-degrading chimeras; motor cortex infusion for mice Organism or Cell Type:
cell culture: HEK293T cells, primary cortical neurons from humanized SNCA mice and human IPSC–derived cortical neurons; humanized SNCA mice Citation Extract: Wang N, Hegde S, Tang Z, Liu H, Feng G, Niu L, Liu B, Li H, Zhang X, Gadhave K, Kumbhar R, Jiang L, Liu Y, Luo M, Zhang S, Dawson TM, Pantelyat A, Rosenthal LS, Ying M, Mao X, Wang J
. Targeted α-synuclein mRNA degradation by PMO-based RNA-degrading chimeras. Proc Natl Acad Sci U S A. 2026 Jul 21;123(29):e2526461123. |
Oxidized PDI promotes thrombus formation in oxidative stress
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Citation:
Blood. 2026 Jul 16;148(3):376-388 Epub:
Not Epub Abstract:
Protein disulfide isomerase (PDI) functions in thrombus formation in vivo and represents a viable target for antithrombotic... Delivery Method:
intravenous (i.v.) injection Organism or Cell Type:
C57Bl/6J and R120D PDI mutant mice Citation Extract: Yang M, Owegie OC, Patel A, Kennedy QP, Flaumenhaft JT, Chinnaraj M, Ponzar N, Fulcidor EM, Rico MC, Bhowmik A, Carroll KS, Handy DE, Loscalzo J, Essex DW, Pozzi N, Flaumenhaft R. Oxidized PDI promotes thrombus formation in oxidative stress. Blood. 2026 Jul 16;148(3):376-388. |
SIX1 branchio-oto-renal syndrome variants have different effects on embryonic craniofacial gene expression and cartilage formation
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Citation:
Development. 2026 Jul 1;153(13):dev205428 Epub:
Not Epub Abstract:
SIX1 variants underlying branchio-oto-renal syndrome occur in the SIX domain (SD) or homeodomain (HD). We tested whether... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Coppenrath K, Shaidani NI, Naert T, Majumdar HD, Horb M, Lienkamp SS, Klein SL, Moody SA. SIX1 branchio-oto-renal syndrome variants have different effects on embryonic craniofacial gene expression and cartilage formation. Development. 2026 Jul 1;153(13):dev205428. |
LINC00607 facilitates endothelial VEGF-A receptor FLT1 splicing
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Citation:
Mol Ther. 2026 Jul 1;34(7):4323-4338 Epub:
Not Epub Abstract:
Angiogenesis is a key function of vascular endothelial cells and becomes aberrant in pathologies such as preeclampsia. An... Link:
Delivery Method:
electroporation Organism or Cell Type:
human umbilical vein endothelial cells (HUVECs) Citation Extract: Lam F, Warwick T, Oo JA, Krüger AY, Kreis NN, Diagel A, Izquierdo Ponce J, Tirunagari P, Bayer ME, Nonn O, Dechend R, Walther T, Boon RA, Baker AH, Günther S, Wittig I, Chen Z, Müller-McNicoll M, Louwen F, Brandes RP, Leisegang MS. LINC00607 facilitates endothelial VEGF-A receptor FLT1 splicing. Mol Ther. 2026 Jul 1;34(7):4323-4338. |
ATP6V1B2 Regulating Autophagy Flux To Affect Abnormal Auditory Development
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Citation:
Appl Biochem Biotechnol. 2026 Jul;198(7):5330-5345 Epub:
Not Epub Abstract:
To investigate the expression changes of ATP6V1B2 downregulation in Dominant Deafness-Onychodystrophy syndrome (DDOD syndrome... Delivery Method:
cochlear microinjection Organism or Cell Type:
mice Citation Extract: Feng Z, Li J, Yang Y, Chen M, Wu X, Zhou C. ATP6V1B2 Regulating Autophagy Flux To Affect Abnormal Auditory Development. Appl Biochem Biotechnol. 2026 Jul;198(7):5330-5345. |