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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12095 scientific papers returned from the database with the search filters currently being used below.

Gluconeogenesis in the extraembryonic yolk syncytial layer of the zebrafish embryo

Authors:
Furukawa F, Aoyagi A, Sano K, Sameshima K, Goto M, Tseng Y, Ikeda D, Lin C, Uchida K, Okumura S, Yasumoto K, Jimbo M, Hwang P.
Citation:
PNAS Nexus, Volume 3, Issue 4, April 2024, pgae125, doi.org/10.1093/pnasnexus/pgae125
Epub:
Not Epub
Abstract:
Yolk-consuming (lecithotrophic) embryos of oviparous animals, such as those of fish, need to make do with the maternally...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Furukawa F, Aoyagi A, Sano K, Sameshima K, Goto M, Tseng Y, Ikeda D, Lin C, Uchida K, Okumura S, Yasumoto K, Jimbo M, Hwang P.. Gluconeogenesis in the extraembryonic yolk syncytial layer of the zebrafish embryo. PNAS Nexus, Volume 3, Issue 4, April 2024, pgae125, doi.org/10.1093/pnasnexus/pgae125.

Mycobacterium Tuberculosis Hijacks Host Macrophages-Derived Interleukin 16 to Block Phagolysosome Maturation for Enhancing Intracellular Growth.

Authors:
Su H, Weng S, Luo L, Sun Q, Lin T, Ma H, He Y, Wu J, Wang H, Zhang W, Xu Y.
Citation:
Emerging Microbes & Infections 13, no. 1 (2024). doi:10.1080/22221751.2024.2322663.
Epub:
Not Epub
Abstract:
The discovery of promising cytokines and clarification of their immunological mechanisms in controlling the intracellular fate...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Su H, Weng S, Luo L, Sun Q, Lin T, Ma H, He Y, Wu J, Wang H, Zhang W, Xu Y.. Mycobacterium Tuberculosis Hijacks Host Macrophages-Derived Interleukin 16 to Block Phagolysosome Maturation for Enhancing Intracellular Growth.. Emerging Microbes & Infections 13, no. 1 (2024). doi:10.1080/22221751.2024.2322663..

A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.

Authors:
Han Y, Sun K, Yu S, Qin Y, Zhang Z, Luo J, Hu H, Dai L, Cui M, Jiang C, Liu F, Huang Y, Gao P, Chen X, Xin T, Ren X, Wu X, Song J, Wang Q, Tang Z, Chen J, Zhang H, Zhang X, Liu M, Luo D.
Citation:
The EMBO Journal 0(0): 1-25. doi.org/10.1038/s44318-024-00082-9
Epub:
Not Epub
Abstract:
Prenatal lethality associated with mouse knockout of Mettl16, a recently identified RNA N6-methyladenosine (m6A)...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Han Y, Sun K, Yu S, Qin Y, Zhang Z, Luo J, Hu H, Dai L, Cui M, Jiang C, Liu F, Huang Y, Gao P, Chen X, Xin T, Ren X, Wu X, Song J, Wang Q, Tang Z, Chen J, Zhang H, Zhang X, Liu M, Luo D.. A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells.. The EMBO Journal 0(0): 1-25. doi.org/10.1038/s44318-024-00082-9.

Microglia Mitigate Neuronal Activation in a Zebrafish Model of Dravet Syndrome.

Authors:
Brenet A, Somkhit J, Csaba Z, Ciura S, Kabashi E, Yanicostas C, Soussi-Yanicostas N.
Citation:
Cells. 2024; 13(8):684. doi.org/10.3390/cells13080684
Epub:
Not Epub
Abstract:
It has been known for a long time that epileptic seizures provoke brain neuroinflammation involving the activation of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Brenet A, Somkhit J, Csaba Z, Ciura S, Kabashi E, Yanicostas C, Soussi-Yanicostas N.. Microglia Mitigate Neuronal Activation in a Zebrafish Model of Dravet Syndrome.. Cells. 2024; 13(8):684. doi.org/10.3390/cells13080684.

Generalizable anchor aptamer strategy for loading nucleic acid therapeutics on exosomes.

Authors:
Han G, Zhang Y, Zhong L, Wang B, Qiu S, Song J, Lin C, Zou F, Wu J, Yu H, Liang C, Wen K, Seow Y, Yin H.
Citation:
EMBO Mol Med. 2024 Mar 6. doi: 10.1038/s44321-024-00049-7. Online ahead of print.
Epub:
Not Epub
Abstract:
Clinical deployment of oligonucleotides requires delivery technologies that improve stability, target tissue accumulation and...
Delivery Method:
PMO loaded on exosomes
Organism or Cell Type:
Mouse
Citation Extract:
Han G, Zhang Y, Zhong L, Wang B, Qiu S, Song J, Lin C, Zou F, Wu J, Yu H, Liang C, Wen K, Seow Y, Yin H.. Generalizable anchor aptamer strategy for loading nucleic acid therapeutics on exosomes.. EMBO Mol Med. 2024 Mar 6. doi: 10.1038/s44321-024-00049-7. Online ahead of print..

Synthesis and Biophysical Properties of Triazole-Incorporated PMOs (TzPMOs): A Convergent, Click Ligation Approach.

Authors:
Banerjee A, Das A, Ghosh A, Gupta A, Sinha S.
Citation:
J Org Chem. 2024 Mar 1;89(5):2895-2903. doi: 10.1021/acs.joc.3c02242. Epub 2024 Feb 12.
Epub:
Not Epub
Abstract:
The synthesis of phosphorodiamidate morpholino oligonucleotides (PMOs) incorporating single or double triazole rings in the...
Delivery Method:
triazole-incorporated PMOs
Citation Extract:
Banerjee A, Das A, Ghosh A, Gupta A, Sinha S.. Synthesis and Biophysical Properties of Triazole-Incorporated PMOs (TzPMOs): A Convergent, Click Ligation Approach.. J Org Chem. 2024 Mar 1;89(5):2895-2903. doi: 10.1021/acs.joc.3c02242. Epub 2024 Feb 12..

Endothelial Cell Flow-Mediated Quiescence Is Temporally Regulated and Utilizes the Cell Cycle Inhibitor p27

Authors:
Tanke NT, Liu Z, Gore MT, Bougaran P, Linares MB, Marvin A, Sharma A, Oatley M, Yu T, Quigley K, Vest S, Cook JG, Bautch VL.
Citation:
Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1265-1282. doi: 10.1161/ATVBAHA.124.320671. Epub 2024 Apr 11. PMID: 38602102.
Epub:
Not Epub
Abstract:
Endothelial cells regulate their cell cycle as blood vessels remodel and transition to quiescence downstream of blood flow-...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tanke NT, Liu Z, Gore MT, Bougaran P, Linares MB, Marvin A, Sharma A, Oatley M, Yu T, Quigley K, Vest S, Cook JG, Bautch VL.. Endothelial Cell Flow-Mediated Quiescence Is Temporally Regulated and Utilizes the Cell Cycle Inhibitor p27. Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1265-1282. doi: 10.1161/ATVBAHA.124.320671. Epub 2024 Apr 11. PMID: 38602102..

METTL3-dependent m6A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway.

Authors:
Ma L, Zhou X, Yao S, Zhang X, Mao J, Vona B, Fan L, Lou S, Li D, Wang L, Pan Y.
Citation:
Cell Death Dis. 2024 Mar 20;15(3):229. doi: 10.1038/s41419-024-06606-9.
Epub:
Not Epub
Abstract:
Craniofacial malformations, often associated with syndromes, are prevalent birth defects. Emerging evidence underscores the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ma L, Zhou X, Yao S, Zhang X, Mao J, Vona B, Fan L, Lou S, Li D, Wang L, Pan Y.. METTL3-dependent m6A modification of PSEN1 mRNA regulates craniofacial development through the Wnt/β-catenin signaling pathway.. Cell Death Dis. 2024 Mar 20;15(3):229. doi: 10.1038/s41419-024-06606-9..

Differentiation and functioning of the lateral line organ in zebrafish require Smpx activity

Authors:
Diana A, Ghilardi A, Del Giacco L
Citation:
Sci Rep. 2024 Apr 3;14(1):7862. doi: 10.1038/s41598-024-58138-z
Epub:
Not Epub
Abstract:
The small muscle protein, X-linked (SMPX) gene encodes a cytoskeleton-associated protein, highly expressed in the inner ear...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Diana A, Ghilardi A, Del Giacco L. Differentiation and functioning of the lateral line organ in zebrafish require Smpx activity. Sci Rep. 2024 Apr 3;14(1):7862. doi: 10.1038/s41598-024-58138-z.

The transcription of the main gene associated with Treacher-Collins syndrome (TCOF1) is regulated by G-quadruplexes and cellular nucleic acid binding protein (CNBP)

Authors:
Gil Rosas M, Centola C, Torres M, Mouguelar VS, David AP, Piga EJ, Gomez D, Calcaterra NB, Armas P, Coux G
Citation:
Sci Rep. 2024 Mar 29;14(1):7472. doi: 10.1038/s41598-024-58255-9
Epub:
Not Epub
Abstract:
Treacle ribosome biogenesis factor 1 (TCOF1) is responsible for about 80% of mandibular dysostosis (MD) cases. We have formerly...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gil Rosas M, Centola C, Torres M, Mouguelar VS, David AP, Piga EJ, Gomez D, Calcaterra NB, Armas P, Coux G. The transcription of the main gene associated with Treacher-Collins syndrome (TCOF1) is regulated by G-quadruplexes and cellular nucleic acid binding protein (CNBP). Sci Rep. 2024 Mar 29;14(1):7472. doi: 10.1038/s41598-024-58255-9.

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