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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9876 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Cryptic exon activation causes dystrophinopathy in two Chinese families

Authors:
Jin M, Li J-J, Xu G-R, Wang N, Wang Z-Q
Citation:
Eur J Hum Genet. 2020;[epub ahead of print] doi:10.1038/s41431-020-0578-z
Abstract:
The X-linked recessive degenerative disease dystrophinopathy results from variants in the DMD gene. Given the large size and...
Citation Extract:
Jin M, Li J-J, Xu G-R, Wang N, Wang Z-Q. Cryptic exon activation causes dystrophinopathy in two Chinese families. Eur J Hum Genet. 2020;[epub ahead of print] doi:10.1038/s41431-020-0578-z.

Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy

Authors:
Zhou H, Meng J, Malerba A, Catapano F, Sintusek P, Jarmin S, Feng L, Lu-Nguyen N, Sun L, Mariot V, Dumonceaux J, Morgan JE, Gissen P, Dickson G, Muntoni F
Citation:
J Cachexia Sarcopenia Muscle. 2020 Feb 7. doi: 10.1002/jcsm.12542. [Epub ahead of print]
Abstract:
BACKGROUND: Spinal muscular atrophy (SMA) is caused by genetic defects in the survival motor neuron 1 (SMN1) gene that lead to...
Delivery Method:
s.c. injection
Organism or Cell Type:
mice
Citation Extract:
Zhou H, Meng J, Malerba A, Catapano F, Sintusek P, Jarmin S, Feng L, Lu-Nguyen N, Sun L, Mariot V, Dumonceaux J, Morgan JE, Gissen P, Dickson G, Muntoni F. Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy. J Cachexia Sarcopenia Muscle. 2020 Feb 7. doi: 10.1002/jcsm.12542. [Epub ahead of print].

Assessing intracellular pH regulation in H+-ATPase-rich ionocytes in zebrafish larvae using in vivo ratiometric imaging

Authors:
Yew HM, Zimmer AM, Perry SF
Citation:
J Exper Biol. 2020;[Epub ahead of print] doi:10.1242/jeb.212928
Abstract:
The H+-ATPase rich (HR) cells of zebrafish larvae are a sub-type of ion-transporting cell located on the yolk sac epithelium...
Organism or Cell Type:
zebrafish
Citation Extract:
Yew HM, Zimmer AM, Perry SF. Assessing intracellular pH regulation in H+-ATPase-rich ionocytes in zebrafish larvae using in vivo ratiometric imaging. J Exper Biol. 2020;[Epub ahead of print] doi:10.1242/jeb.212928.

Unravelling the developmental and functional significance of an ancient Argonaute duplication

Authors:
Fridrich A, Modepalli V, Lewandowska M, Aharoni R, Moran Y
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.02.04.933887
Abstract:
microRNAs (miRNAs), base-pair to messenger RNA targets and guide Argonaute proteins to mediate their silencing. This target...
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Fridrich A, Modepalli V, Lewandowska M, Aharoni R, Moran Y. Unravelling the developmental and functional significance of an ancient Argonaute duplication. bioRxiv. 2020;[preprint] doi:10.1101/2020.02.04.933887.

Latrophilins are essential for endothelial junctional fluid shear stress mechanotransduction

Authors:
Tanaka K, Prendergast A, Hintzen J, Kumar A, Chung M, Koleske A, Crawford J, Nicoli S, Schwartz MA
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.02.03.932822
Abstract:
Endothelial cell (EC) responses to fluid shear stress (FSS) are crucial for vascular development, adult physiology and disease...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tanaka K, Prendergast A, Hintzen J, Kumar A, Chung M, Koleske A, Crawford J, Nicoli S, Schwartz MA. Latrophilins are essential for endothelial junctional fluid shear stress mechanotransduction. bioRxiv. 2020;[preprint] doi:10.1101/2020.02.03.932822 .

Thalidomide targets EGFL6 to inhibit EGFL6/PAX6 axis-driven angiogenesis in small bowel vascular malformation

Authors:
Tang CT, Zhang QW, Wu S, Tang MY, Liang Q, Lin XL, Gao YJ, Ge ZZ
Citation:
Cell Mol Life Sci. 2020 Feb 1. doi: 10.1007/s00018-020-03465-3. [Epub ahead of print]
Abstract:
Background: Small bowel vascular malformation disease (SBVM) is the most common cause of obscure gastrointestinal bleeding (...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tang CT, Zhang QW, Wu S, Tang MY, Liang Q, Lin XL, Gao YJ, Ge ZZ. Thalidomide targets EGFL6 to inhibit EGFL6/PAX6 axis-driven angiogenesis in small bowel vascular malformation. Cell Mol Life Sci. 2020 Feb 1. doi: 10.1007/s00018-020-03465-3. [Epub ahead of print].

Abnormal expression of GABAA receptor sub-units and hypomotility upon loss of gabra1 in zebrafish

Authors:
Reyes-Nava N, Yu H-C, Coughlin CR II, Shaikh TH, Quintana AM
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.31.929455
Abstract:
We used whole exome sequencing (WES) to determine the genetic etiology of a patient with a multi-system disorder characterized...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Reyes-Nava N, Yu H-C, Coughlin CR II, Shaikh TH, Quintana AM. Abnormal expression of GABAA receptor sub-units and hypomotility upon loss of gabra1 in zebrafish. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.31.929455 .

Sox2 and canonical Wnt signaling interact to activate a developmental checkpoint coordinating morphogenesis with mesodermal fate acquisition

Authors:
Kinney BA, Row RH, Tseng Y-J, Weidmann MD, Knaut H, Martin BL
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.29.924050
Abstract:
Animal embryogenesis requires a precise coordination between morphogenesis and cell fate specification. It is unclear if there...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kinney BA, Row RH, Tseng Y-J, Weidmann MD, Knaut H, Martin BL. Sox2 and canonical Wnt signaling interact to activate a developmental checkpoint coordinating morphogenesis with mesodermal fate acquisition. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.29.924050.

Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons

Authors:
Sitaraman S, Yadav G, Jabeen S, Agarwal V, Thirumalai V
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.31.928242
Abstract:
Gap junctions between neurons serve as electrical synapses, in addition to conducting metabolites and signaling molecules....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sitaraman S, Yadav G, Jabeen S, Agarwal V, Thirumalai V. Gjd2b-mediated gap junctions promote glutamatergic synapse formation and dendritic elaboration in Purkinje neurons. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.31.928242.

Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development

Authors:
Rojas-Benítez D, Allende ML
Citation:
Int J Mol Sci. 2020;21(3):925. doi:10.3390/ijms21030925
Abstract:
Transfer RNAs (tRNAs) are the most post-transcriptionally modified RNA species. Some of these modifications, especially the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rojas-Benítez D, Allende ML. Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development. Int J Mol Sci. 2020;21(3):925. doi:10.3390/ijms21030925.

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