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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9947 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Combined treatment with peptide-conjugated phosphorodiamidate morpholino oligomer-PPMO and AAV-U7 rescues the severe DMD phenotype in mice

Authors:
Forand A, Muchir A, Mougenot N, Sevoz-Couche C, Peccate C, Lemaitre M, Izabelle C, Wood MJA, Lorain SL, Piétri-Rouxel F
Citation:
Molec Ther Methods Clin Devel. 2020;[Epub] doi:10.1016/j.omtm.2020.03.011
Abstract:
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease caused by an absence of the dystrophin protein, which...
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Forand A, Muchir A, Mougenot N, Sevoz-Couche C, Peccate C, Lemaitre M, Izabelle C, Wood MJA, Lorain SL, Piétri-Rouxel F. Combined treatment with peptide-conjugated phosphorodiamidate morpholino oligomer-PPMO and AAV-U7 rescues the severe DMD phenotype in mice. Molec Ther Methods Clin Devel. 2020;[Epub] doi:10.1016/j.omtm.2020.03.011.

A nonsense variant in NME5 causes human primary ciliary dyskinesia with radial spoke defects

Authors:
Cho EH, Huh HJ, Jeong I, Lee NY, Koh WJ, Park HC, Ki CS
Citation:
Clin Genet. 2020 Mar 17. doi: 10.1111/cge.13742. [Epub ahead of print]
Abstract:
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder characterized by defects in the function or structure...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cho EH, Huh HJ, Jeong I, Lee NY, Koh WJ, Park HC, Ki CS. A nonsense variant in NME5 causes human primary ciliary dyskinesia with radial spoke defects. Clin Genet. 2020 Mar 17. doi: 10.1111/cge.13742. [Epub ahead of print].

The vitamin B12 processing enzyme, mmachc, is essential for zebrafish survival, growth and retinal morphology

Authors:
Sloan JL, Achilly NP, Arnold ML, Catlett JL, Blake T, Bishop K, Jones M, Harper U, English MA, Anderson S, Trivedi NS, Elkahloun A, Hoffmann V, Brooks BP, Sood R, Venditti CP
Citation:
Hum Molec Genet. 2020;[Epub anead of print] doi:10.1093/hmg/ddaa044
Abstract:
Cobalamin C deficiency (cblC), the most common inborn error of intracellular cobalamin metabolism, is caused by mutations in...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sloan JL, Achilly NP, Arnold ML, Catlett JL, Blake T, Bishop K, Jones M, Harper U, English MA, Anderson S, Trivedi NS, Elkahloun A, Hoffmann V, Brooks BP, Sood R, Venditti CP. The vitamin B12 processing enzyme, mmachc, is essential for zebrafish survival, growth and retinal morphology. Hum Molec Genet. 2020;[Epub anead of print] doi:10.1093/hmg/ddaa044.

Gsx2 is involved in specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neuronal progenitors in zebrafish

Authors:
Itoh T, Miki T, Sakagami M, Asakawa K, Kawakami K, Shimizu T, Hibi M
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.03.16.993402
Abstract:
Neurons in the inferior olivary nuclei (IO neurons) send climbing fibers to Purkinje cells to elicit functions of the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Itoh T, Miki T, Sakagami M, Asakawa K, Kawakami K, Shimizu T, Hibi M. Gsx2 is involved in specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neuronal progenitors in zebrafish. bioRxiv. 2020;[preprint] doi:10.1101/2020.03.16.993402 .

Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome

Authors:
Wu Y, Xia Y, Li P, Qu H-Q, Liu Y, Yang Y, Lin J, Zheng M, Tian L, Wu Z, Huang S, Qin X, Zhou X, Chen S, Liu Y, Wang Y, Li X, Zeng H, Hakonarson H, Zhuang J
Citation:
Research Square. 2020;[preprint] doi:10.21203/rs.2.19377/v2
Abstract:
Background : Rubinstein–Taybi syndrome (RSTS) is a rare, congenital, plurimalformative, and neurodevelopmental disorder....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu Y, Xia Y, Li P, Qu H-Q, Liu Y, Yang Y, Lin J, Zheng M, Tian L, Wu Z, Huang S, Qin X, Zhou X, Chen S, Liu Y, Wang Y, Li X, Zeng H, Hakonarson H, Zhuang J. Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome. Research Square. 2020;[preprint] doi:10.21203/rs.2.19377/v2.

The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils

Authors:
Prajsnar TK, Serba JJ, Dekker BM, Gibson JF, Masud S, Fleming A, Johnston SA, Renshaw SA, Meijer AH
Citation:
Autophagy. 2020;[Epub] doi:10.1080/15548627.2020.1739443
Abstract:
Staphylococcus aureus is a major human pathogen causing multiple pathologies, from cutaneous lesions to life-threatening sepsis...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Prajsnar TK, Serba JJ, Dekker BM, Gibson JF, Masud S, Fleming A, Johnston SA, Renshaw SA, Meijer AH. The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils. Autophagy. 2020;[Epub] doi:10.1080/15548627.2020.1739443.

FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells

Authors:
Smith JA, Curry EG, Blue RE, Roden C, Dundon SER, Rodríguez-Vargas A, Jordan DC, Chen X, Lyons SM, Crutchley J, Anderson P, Horb ME, Gladfelter AS , Giudice J
Citation:
J Cell Biol. 2020;219(4):e201911129. doi:10.1083/jcb.201911129
Abstract:
Fragile-X mental retardation autosomal homologue-1 (FXR1) is a muscle-enriched RNA-binding protein. FXR1 depletion is...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Smith JA, Curry EG, Blue RE, Roden C, Dundon SER, Rodríguez-Vargas A, Jordan DC, Chen X, Lyons SM, Crutchley J, Anderson P, Horb ME, Gladfelter AS , Giudice J. FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. J Cell Biol. 2020;219(4):e201911129. doi:10.1083/jcb.201911129.

Genetic Compensation of γ CaMKII, an Evolutionarily Conserved Gene

Authors:
Rothschild SC, Ingram SR, Lu FI, Thisse B, Thisse C, Parkerson JA, Tombes RM
Citation:
Gene. 2020 Mar 9:144567. doi: 10.1016/j.gene.2020.144567. [Epub ahead of print]
Abstract:
CaMKII is a Ca2+/CaM-dependent protein kinase encoded by a family of conserved genes found throughout all metazoan species and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rothschild SC, Ingram SR, Lu FI, Thisse B, Thisse C, Parkerson JA, Tombes RM. Genetic Compensation of γ CaMKII, an Evolutionarily Conserved Gene. Gene. 2020 Mar 9:144567. doi: 10.1016/j.gene.2020.144567. [Epub ahead of print].

The zebrafish Znt1asa17 mutant reveals roles of zinc transporter-1a in embryonic development

Authors:
Muraina IA, Bury NR, Scott A, Graham A, Hogstrand C
Citation:
J Trace Elem Med Bio. 2020 Mar 12;60:126496. doi: 10.1016/j.jtemb.2020.126496. [Epub ahead of print]
Abstract:
Background: Zinc is one of the vital micronutrients required through various developmental stages in animals. Zinc transporter-...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Muraina IA, Bury NR, Scott A, Graham A, Hogstrand C. The zebrafish Znt1asa17 mutant reveals roles of zinc transporter-1a in embryonic development. J Trace Elem Med Bio. 2020 Mar 12;60:126496. doi: 10.1016/j.jtemb.2020.126496. [Epub ahead of print].

miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation

Authors:
Adusumilli L, Facchinello N, Teh C, Busolin G, Le TM, Yang H, Beffagna G, Campanaro S, Tam LW, Argenton F, Lim B, Korzh V, Tiso N
Citation:
Cells. 2020;9(3):2073-4409 doi:10.3390/cells9030711
Abstract:
During the development of the central nervous system, the proliferation of neural progenitors and differentiation of neurons...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Adusumilli L, Facchinello N, Teh C, Busolin G, Le TM, Yang H, Beffagna G, Campanaro S, Tam LW, Argenton F, Lim B, Korzh V, Tiso N. miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation. Cells. 2020;9(3):2073-4409 doi:10.3390/cells9030711.

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