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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9716 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH

Authors:
Huang W, Liu Z, Yang F, Zhou H, Yong X, Yang X, Zhou Y, Xue L, Zhang Y, Liu D, Meng W, Zhang W, Zhang X, Shen X, Sun Q, Li L, Ma C, Wei Y, Billadeau DD, Mo X, Jia D
Citation:
Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22598-22608. doi: 10.1073/pnas.1909316116. Epub 2019 Oct 17
Abstract:
Pontocerebellar hypoplasia (PCH) is a group of neurological disorders that affect the development of the brain, in particular,...
Organism or Cell Type:
zebrafish
Citation Extract:
Huang W, Liu Z, Yang F, Zhou H, Yong X, Yang X, Zhou Y, Xue L, Zhang Y, Liu D, Meng W, Zhang W, Zhang X, Shen X, Sun Q, Li L, Ma C, Wei Y, Billadeau DD, Mo X, Jia D. Structural and functional studies of TBC1D23 C-terminal domain provide a link between endosomal trafficking and PCH. Proc Natl Acad Sci U S A. 2019 Nov 5;116(45):22598-22608. doi: 10.1073/pnas.1909316116. Epub 2019 Oct 17.

Trpc1 as the Missing Link Between the Bmp and Ca2+ Signalling Pathways During Neural Specification in Amphibians

Authors:
Néant I, Leung HC, Webb SE, Miller AL, Moreau M, Leclerc C
Citation:
Sci Rep. 2019 Nov 5;9(1):16049. doi: 10.1038/s41598-019-52556-0
Abstract:
In amphibians, the inhibition of bone morphogenetic protein (BMP) in the dorsal ectoderm has been proposed to be responsible...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Néant I, Leung HC, Webb SE, Miller AL, Moreau M, Leclerc C. Trpc1 as the Missing Link Between the Bmp and Ca2+ Signalling Pathways During Neural Specification in Amphibians. Sci Rep. 2019 Nov 5;9(1):16049. doi: 10.1038/s41598-019-52556-0.

Targeted resequencing identifies genes with recurrent variation in cerebral palsy

Authors:
van Eyk CL, Corbett MA, Frank MSB, Webber DL, Newman M, Berry JG, Harper K, Haines BP, McMichael G, Woenig JA, MacLennan AH, Gecz J
Citation:
NPJ Genom Med. 2019 Nov 4;4:27. doi: 10.1038/s41525-019-0101-z. eCollection 2019
Abstract:
A growing body of evidence points to a considerable and heterogeneous genetic aetiology of cerebral palsy (CP). To identify...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
van Eyk CL, Corbett MA, Frank MSB, Webber DL, Newman M, Berry JG, Harper K, Haines BP, McMichael G, Woenig JA, MacLennan AH, Gecz J. Targeted resequencing identifies genes with recurrent variation in cerebral palsy. NPJ Genom Med. 2019 Nov 4;4:27. doi: 10.1038/s41525-019-0101-z. eCollection 2019.

CNS myelin protein 36K regulates oligodendrocyte differentiation through Notch

Authors:
Nagarajan B, Harder A, Japp A, Häberlein F, Mingardo E, Kleinert H, Yilmaz Ö, Zoons A, Rau B, Christ A, Kubitscheck U, Eiberger B, Sandhoff R, Eckhardt M, Hartmann D, Odermatt B
Citation:
Glia. 2019 Nov 8. doi: 10.1002/glia.23732. [Epub ahead of print]
Abstract:
In contrast to humans and other mammals, zebrafish can successfully regenerate and remyelinate central nervous system (CNS)...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nagarajan B, Harder A, Japp A, Häberlein F, Mingardo E, Kleinert H, Yilmaz Ö, Zoons A, Rau B, Christ A, Kubitscheck U, Eiberger B, Sandhoff R, Eckhardt M, Hartmann D, Odermatt B. CNS myelin protein 36K regulates oligodendrocyte differentiation through Notch. Glia. 2019 Nov 8. doi: 10.1002/glia.23732. [Epub ahead of print].

AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos

Authors:
Jin H, Ji C, Ren F, Aniagu S, Tong J, Jiang Y, Chen T
Citation:
J Hazard Mater. 2019 Oct 25:121521. doi: 10.1016/j.jhazmat.2019.121521. [Epub ahead of print]
Abstract:
Trichloroethylene (TCE), a widely used chlorinated solvent, is a common environmental pollutant. Current evidence shows that...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jin H, Ji C, Ren F, Aniagu S, Tong J, Jiang Y, Chen T. AHR-mediated oxidative stress contributes to the cardiac developmental toxicity of trichloroethylene in zebrafish embryos. J Hazard Mater. 2019 Oct 25:121521. doi: 10.1016/j.jhazmat.2019.121521. [Epub ahead of print].

Effects of Proximal Tubule Shortening on Protein Excretion in a Lowe Syndrome Model

Authors:
Gliozzi ML, Espiritu EB, Shipman KE, Rbaibi Y, Long KR, Roy N, Duncan AW, Lazzara MJ, Hukriede NA, Baty CJ, Weisz OA
Citation:
J Am Soc Nephrol. 2019 Nov 1. pii: ASN.2019020125. doi: 10.1681/ASN.2019020125. [Epub ahead of print]
Abstract:
BACKGROUND: Lowe syndrome (LS) is an X-linked recessive disorder caused by mutations in OCRL, which encodes the enzyme OCRL....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gliozzi ML, Espiritu EB, Shipman KE, Rbaibi Y, Long KR, Roy N, Duncan AW, Lazzara MJ, Hukriede NA, Baty CJ, Weisz OA. Effects of Proximal Tubule Shortening on Protein Excretion in a Lowe Syndrome Model. J Am Soc Nephrol. 2019 Nov 1. pii: ASN.2019020125. doi: 10.1681/ASN.2019020125. [Epub ahead of print].

Genes and Variants Underlying Human Congenital Lactic Acidosis—From Genetics to Personalized Treatment

Authors:
Bravo-Alonso I, Navarrete R, Vega AI, Ruíz-Sala P, Silva MTG, Martín-Hernández E, Quijada-Fraile P, Belanger-Quintana A, Stanescu S, Bueno M, Vitoria I, Toledo L, Couce ML, García-Jiménez I, Ramos-Ruiz R, Martín MA, Desviat LR, Ugarte M, Pérez-Cerdá C, Merinero B, Pérez B, Rodríguez-Pombo P
Citation:
J Clin Med. 2019;8(11):1811. doi:10.3390/jcm8111811
Abstract:
Congenital lactic acidosis (CLA) is a rare condition in most instances due to a range of inborn errors of metabolism that...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: patient fibroblasts
Citation Extract:
Bravo-Alonso I, Navarrete R, Vega AI, Ruíz-Sala P, Silva MTG, Martín-Hernández E, Quijada-Fraile P, Belanger-Quintana A, Stanescu S, Bueno M, Vitoria I, Toledo L, Couce ML, García-Jiménez I, Ramos-Ruiz R, Martín MA, Desviat LR, Ugarte M, Pérez-Cerdá C, Merinero B, Pérez B, Rodríguez-Pombo P. Genes and Variants Underlying Human Congenital Lactic Acidosis—From Genetics to Personalized Treatment. J Clin Med. 2019;8(11):1811. doi:10.3390/jcm8111811.

An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Authors:
Evans BC, Fletcher RB, Kilchrist KV, Dailing EA, Mukalel AJ, Colazo JM, Oliver M, Cheung-Flynn J, Brophy CM, Tierney JW, Isenberg JS, Hankenson KD, Ghimire K, Lander C, Gersbach CA, Duvall CL
Citation:
Nat Comm. 2019;10:5012. doi:10.1038/s41467-019-12906-y
Abstract:
Peptides and biologics provide unique opportunities to modulate intracellular targets not druggable by conventional small...
Delivery Method:
Vivo-Morpholino with anionic delivery polymer PPAA
Organism or Cell Type:
cell culture: human microvascular endothelial cells HMVEC
Citation Extract:
Evans BC, Fletcher RB, Kilchrist KV, Dailing EA, Mukalel AJ, Colazo JM, Oliver M, Cheung-Flynn J, Brophy CM, Tierney JW, Isenberg JS, Hankenson KD, Ghimire K, Lander C, Gersbach CA, Duvall CL. An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. Nat Comm. 2019;10:5012. doi:10.1038/s41467-019-12906-y.

A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing

Authors:
Chen T, Zhang B, Ziegenhals T, Prusty AB, Fröhler S, Grimm C, Hu Y, Schaefke B, Fang L, Zhang M, Kraemer N, Kaindl AM, Fischer U, Chen W
Citation:
PLoS Genet. 2019;15(10):e1008460. doi:10.1371/journal.pgen.1008460
Abstract:
Malfunction of pre-mRNA processing factors are linked to several human diseases including cancer and neurodegeneration. Here we...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen T, Zhang B, Ziegenhals T, Prusty AB, Fröhler S, Grimm C, Hu Y, Schaefke B, Fang L, Zhang M, Kraemer N, Kaindl AM, Fischer U, Chen W. A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing. PLoS Genet. 2019;15(10):e1008460. doi:10.1371/journal.pgen.1008460.

Synchronous chromosome segregation in mouse oocytes is ensured by biphasic securin destruction and cyclin B1-Cdk1

Authors:
Thomas C, Levasseur MD, Harris RJ, Davies OR, Madgwick S
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/824763
Abstract:
Successful cell division relies on the faithful segregation of chromosomes. If chromosomes segregate prematurely the cell is at...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Thomas C, Levasseur MD, Harris RJ, Davies OR, Madgwick S. Synchronous chromosome segregation in mouse oocytes is ensured by biphasic securin destruction and cyclin B1-Cdk1. bioRxiv. 2019;[preprint] doi:10.1101/824763 .

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