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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12420 scientific papers returned from the database with the search filters currently being used below.
There are 12420 scientific papers returned from the database with the search filters currently being used below.
Positive modulation of sigma-1 receptor: a new weapon to mitigate disease progression in amyotrophic lateral sclerosis
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Citation:
Transl Neurodegener. 2025 Dec 15;14(1):68. doi: 10.1186/s40035-025-00527-z. PMID: 41392158; PMCID: PMC12703938 Epub:
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Background: Amyotrophic lateral sclerosis (ALS) is characterised by degeneration of motor neurons, leading to muscle weakness... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Le Friec J, Mourier H, Couly S, Cubedo N, Dubois K, Meunier J, Delprat B, De Zordo-Banliat A, Ayad T, Virieux D, Su TP, Lasbleiz C, Maurice T, Liévens JC. Positive modulation of sigma-1 receptor: a new weapon to mitigate disease progression in amyotrophic lateral sclerosis. Transl Neurodegener. 2025 Dec 15;14(1):68. doi: 10.1186/s40035-025-00527-z. PMID: 41392158; PMCID: PMC12703938. |
A novel and critical role of the intracellular Zona Pellucida protein 2 (ZP2) for blastocyst formation in mice
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Citation:
bioRxiv [preprint] 2025.12.12.692802; doi: https://doi.org/10.64898/2025.12.12.692802 Epub:
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The zona pellucida (ZP) is the quintessential extracellular structure of mammalian oocytes. Contrary to long-standing view that... Delivery Method:
microinjection Organism or Cell Type:
mouse zygotes from B6C3F1 females mated to CD1 males Citation Extract: Nolte T, Israel S, Drexler HCA, Fuellen G, Boiani M. A novel and critical role of the intracellular Zona Pellucida protein 2 (ZP2) for blastocyst formation in mice. bioRxiv [preprint] 2025.12.12.692802; doi: https://doi.org/10.64898/2025.12.12.692802. |
In vivo imaging reveals exosome-mediated intercellular communication in lens development
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Citation:
Commun Biol 8, 1774 (2025). https://doi.org/10.1038/s42003-025-09159-5 Epub:
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Lens transparency relies on proper intercellular communication. Exosomes are crucial mediators of intercellular communication... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ma J, Sun Q, Chen Y, Li J, Ouyang S, Ke S, Li J, Liang H, Chen S, Luo L. In vivo imaging reveals exosome-mediated intercellular communication in lens development. Commun Biol 8, 1774 (2025). https://doi.org/10.1038/s42003-025-09159-5. |
Suppression of brain aromatase decreases the expression of dopaminergic neuron in early development of zebrafish
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Citation:
Fish Physiol Biochem. 2025 Dec 13;51(6):204. doi: 10.1007/s10695-025-01620-w. PMID: 41389094 Epub:
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Cytochrome P450 aromatase, the product of the CYP19A1 gene, is a key enzyme in estrogen biosynthesis. Most teleost fish have... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Fatimah R, Ulhaq ZS, Rafiuddin MA, Kishida M. Suppression of brain aromatase decreases the expression of dopaminergic neuron in early development of zebrafish. Fish Physiol Biochem. 2025 Dec 13;51(6):204. doi: 10.1007/s10695-025-01620-w. PMID: 41389094. |
Pathogenic Mechanism of the KCNQ4 Gene Variant in Hearing Loss and Functional Validation in a Zebrafish Model
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Citation:
FASEB J. 2025 Dec 15;39(23):e71274. doi: 10.1096/fj.202500557R. PMID: 41368761 Epub:
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The KCNQ4 gene is closely associated with autosomal dominant nonsyndromic hearing loss (DFNA2) and encodes a potassium channel... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Jia H, Liu X, Chen H, Wang Y, Guan MX, Guo Y. Pathogenic Mechanism of the KCNQ4 Gene Variant in Hearing Loss and Functional Validation in a Zebrafish Model. FASEB J. 2025 Dec 15;39(23):e71274. doi: 10.1096/fj.202500557R. PMID: 41368761. |
Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis
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Citation:
Proc Natl Acad Sci U S A. 2025 Dec 9;122(49):e2515641122. doi: 10.1073/pnas.2515641122. Epub 2025 Dec 5. PMID: 41348733 Epub:
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During vertebrate embryogenesis, hematopoietic stem and progenitor cells (HSPCs) originate from hemogenic endothelium (HE) in... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Xia J, Shen L, Liu Y, Wang L, Liu F. Ace2 safeguards embryonic hematopoietic stem and progenitor cell production by restraining Nlrp3-mediated pyroptosis. Proc Natl Acad Sci U S A. 2025 Dec 9;122(49):e2515641122. doi: 10.1073/pnas.2515641122. Epub 2025 Dec 5. PMID: 41348733. |
Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling
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Citation:
Cell Rep. 2025 Nov 25;44(11):116544. doi: 10.1016/j.celrep.2025.116544. Epub 2025 Nov 8. PMID: 41206867 Epub:
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Retinal microglia originate during embryonic hematopoiesis and play an essential role in visual function. However, the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Zhan D, Xu L, Mu W, Jin B, Feng Z, Liu S, Wu C, Luo L, Li L. Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling. Cell Rep. 2025 Nov 25;44(11):116544. doi: 10.1016/j.celrep.2025.116544. Epub 2025 Nov 8. PMID: 41206867. |
Multiple retinoic acid pathway factors function together during development of a mollusk
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Citation:
bioRxiv 2025.12.01.691671; doi: https://doi.org/10.64898/2025.12.01.691671 Epub:
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In developing chordate embryos, the retinoic acid (RA) pathway is involved in many key developmental patterning systems.... Delivery Method:
microinjection Organism or Cell Type:
Tritia obsoleta (previously Ilyanassa obsoleta) gastropod Citation Extract: Dao TK & Lambert JD. Multiple retinoic acid pathway factors function together during development of a mollusk. bioRxiv 2025.12.01.691671; doi: https://doi.org/10.64898/2025.12.01.691671. |
The role of AP2M1 in oncofetal characteristics: integrative in silico, in vitro, and in vivo analyses using zebrafish models
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Citation:
Eur J Med Res. 2025 Dec 1. doi: 10.1186/s40001-025-03583-3. Epub ahead of print. PMID: 41327404 Epub:
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Hepatocellular carcinoma (HCC) requires novel therapeutic targets, and oncofetal genes offer a promising avenue. Although the... Delivery Method:
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zebrafish Citation Extract: Ahn S, Baek SE, Yu Y, Kim ES, Myung K, Kim YH, Oh CK. The role of AP2M1 in oncofetal characteristics: integrative in silico, in vitro, and in vivo analyses using zebrafish models. Eur J Med Res. 2025 Dec 1. doi: 10.1186/s40001-025-03583-3. Epub ahead of print. PMID: 41327404. |
A 16-amino acid peptide delays the progression of motor neuron degeneration and pathogenic symptoms in ALS models
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Citation:
Neurotherapeutics. 2025 Nov 25:e00806. doi: 10.1016/j.neurot.2025.e00806. Epub ahead of print. PMID: 41298223 Epub:
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Amyotrophic lateral sclerosis (ALS) is a progressive motor neurons (MNs) degenerative disease. Despite advancements in... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lin CY, Lee BC, Zhang PH, Lu SC, Chang WZ, Wang CC, Tsai HJ. A 16-amino acid peptide delays the progression of motor neuron degeneration and pathogenic symptoms in ALS models. Neurotherapeutics. 2025 Nov 25:e00806. doi: 10.1016/j.neurot.2025.e00806. Epub ahead of print. PMID: 41298223. |