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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12067 scientific papers returned from the database with the search filters currently being used below.

R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient

Authors:
Lee H, Camuto CM, Niehrs C
Citation:
Nat Commun. 2024 Feb 2;15(1):1003. doi: 10.1038/s41467-024-44951-7
Epub:
Not Epub
Abstract:
Establishment of the left-right (LR, sinistral, dextral) body axis in many vertebrate embryos relies on cilia-driven leftward...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Lee H, Camuto CM, Niehrs C. R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient. Nat Commun. 2024 Feb 2;15(1):1003. doi: 10.1038/s41467-024-44951-7.

Prdm15 acts upstream of Wnt4 signaling in anterior neural development of Xenopus laevis

Authors:
Saumweber E, Mzoughi S, Khadra A, Werberger A, Schumann S, Guccione E, Schmeisser MJ, Kühl1 SJ
Citation:
Front Cell Dev Biol. 2024;12:[Epub ahead of full .pdf] doi:10.3389/fcell.2024.1316048
Epub:
Not Epub
Abstract:
Mutations in PRDM15 lead to a syndromic form of holoprosencephaly (HPE) known as Galloway-Mowat syndrome (GAMOS). While a...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Saumweber E, Mzoughi S, Khadra A, Werberger A, Schumann S, Guccione E, Schmeisser MJ, Kühl1 SJ. Prdm15 acts upstream of Wnt4 signaling in anterior neural development of Xenopus laevis. Front Cell Dev Biol. 2024;12:[Epub ahead of full .pdf] doi:10.3389/fcell.2024.1316048.

Generation of glial cell-derived neurotrophic factor (gdnf) morphants in zebrafish larvae by cerebroventricular microinjection of vivo morpholino

Authors:
Noor SM, Wong CED, Wong PF, Norazit A
Citation:
Methods Cell Biol. 2024;181:17-32. doi: 10.1016/bs.mcb.2022.09.004. Epub 2022 Oct 31
Epub:
Not Epub
Abstract:
Dopaminergic neurons in the brain are an important source of dopamine, which is a crucial neurotransmitter for wellbeing,...
Delivery Method:
intracerebroventricular (i.c.v.) injection of Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Noor SM, Wong CED, Wong PF, Norazit A. Generation of glial cell-derived neurotrophic factor (gdnf) morphants in zebrafish larvae by cerebroventricular microinjection of vivo morpholino. Methods Cell Biol. 2024;181:17-32. doi: 10.1016/bs.mcb.2022.09.004. Epub 2022 Oct 31.

Awakening adult neural stem cells: NOX signalling as a positive regulator of the quiescence-to-proliferation transition in the Xenopus retina

Authors:
Donval A, Puente CVH, Lainé A, Roman D, Vessely R, Leclercq J, Perron M, Locker M
Citation:
Development. 2024;151(2):dev201463. doi: 10.1242/dev.201463
Epub:
Not Epub
Abstract:
A growing wealth of data suggest that reactive oxygen species (ROS) signalling might be crucial in conferring embryonic or...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis
Citation Extract:
Donval A, Puente CVH, Lainé A, Roman D, Vessely R, Leclercq J, Perron M, Locker M. Awakening adult neural stem cells: NOX signalling as a positive regulator of the quiescence-to-proliferation transition in the Xenopus retina. Development. 2024;151(2):dev201463. doi: 10.1242/dev.201463.

GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment

Authors:
Williams CH, Neitzel LR, Cornell J, Rea S, Mills I, Silver MS, Ahmad JD, Birukov KG, Birukova A, Brem H, Tyler B, Bar EE, Hong CC
Citation:
Exp Hematol Oncol. 2024 Jan 31;13(1):13. doi: 10.1186/s40164-023-00468-1
Epub:
Not Epub
Abstract:
Background: Glioblastoma multiforme (GBM) stands as a formidable challenge in oncology because of its aggressive nature and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Williams CH, Neitzel LR, Cornell J, Rea S, Mills I, Silver MS, Ahmad JD, Birukov KG, Birukova A, Brem H, Tyler B, Bar EE, Hong CC. GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment. Exp Hematol Oncol. 2024 Jan 31;13(1):13. doi: 10.1186/s40164-023-00468-1.

Zebrafish live imaging reveals only around 2% rather than 50% of motor neurons die through apoptosis during development

Authors:
Jia H, Yang H, Luo K
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.26.577434
Epub:
Not Epub
Abstract:
It is widely accepted that neurons will die through apoptosis if they cannot receive enough growth factors during development...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jia H, Yang H, Luo K. Zebrafish live imaging reveals only around 2% rather than 50% of motor neurons die through apoptosis during development. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.26.577434.

Leucine-rich repeat in polycystin-1 suppresses cystogenesis in a zebrafish (Danio rerio) model of autosomal dominant polycystic kidney disease

Authors:
Padhy B, Amir M, Xie J, Huang C
Citation:
Preprints. 2024;2024011959 [preprint]. doi:10.20944/preprints202401.1959.v1
Epub:
Not Epub
Abstract:
Mutations of PKD1 coding for polycystin-1 (PC1) account for most of the autosomal dominant polycystic kidney disease (ADPKD)....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Padhy B, Amir M, Xie J, Huang C. Leucine-rich repeat in polycystin-1 suppresses cystogenesis in a zebrafish (Danio rerio) model of autosomal dominant polycystic kidney disease. Preprints. 2024;2024011959 [preprint]. doi:10.20944/preprints202401.1959.v1.

Characterization of CD90/Thy-1 as a crucial molecular signature for myogenic differentiation in human urine-derived cells through single-cell RNA sequencing

Authors:
Kunitake K, Motohashi N, Inoue T, Suzuki Y, Aoki Y
Citation:
Sci Rep. 2024 Jan 28;14(1):2329. doi: 10.1038/s41598-024-52530-5
Epub:
Not Epub
Abstract:
Human urine-derived cells (UDCs) are primary cultured cells originating from the upper urinary tract and are known to be...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: Human CD90-positive MYOD1-urine-derived cells
Citation Extract:
Kunitake K, Motohashi N, Inoue T, Suzuki Y, Aoki Y. Characterization of CD90/Thy-1 as a crucial molecular signature for myogenic differentiation in human urine-derived cells through single-cell RNA sequencing. Sci Rep. 2024 Jan 28;14(1):2329. doi: 10.1038/s41598-024-52530-5.

A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish

Authors:
Ikeuchi M, Inoue M, Miyahara H, Sebastian WA, Miyazaki S, Takeno T, Kiyota K, Yano S, Shiraishi H, Shimizu N, Hanada R, Yoshimura A, Ihara K, Hanada T
Citation:
Biochem Biophys Res Commun. 2024 Jan 19;699:149551. doi: 10.1016/j.bbrc.2024.149551. Online ahead of print
Epub:
Not Epub
Abstract:
V-ATPase is an ATP hydrolysis-driven proton pump involved in the acidification of intracellular organelles and systemic acid-...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ikeuchi M, Inoue M, Miyahara H, Sebastian WA, Miyazaki S, Takeno T, Kiyota K, Yano S, Shiraishi H, Shimizu N, Hanada R, Yoshimura A, Ihara K, Hanada T. A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish. Biochem Biophys Res Commun. 2024 Jan 19;699:149551. doi: 10.1016/j.bbrc.2024.149551. Online ahead of print.

Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity

Authors:
Anzell AR, Kunz AB, Donovan JP, Tran TG, Lu X, Young S, Roman BL
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.25.576046
Epub:
Not Epub
Abstract:
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease characterized by the development of arteriovenous...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Anzell AR, Kunz AB, Donovan JP, Tran TG, Lu X, Young S, Roman BL. Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.25.576046.

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