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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12062 scientific papers returned from the database with the search filters currently being used below.

Zebrafish live imaging reveals only around 2% rather than 50% of motor neurons die through apoptosis during development

Authors:
Jia H, Yang H, Luo K
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.26.577434
Epub:
Not Epub
Abstract:
It is widely accepted that neurons will die through apoptosis if they cannot receive enough growth factors during development...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jia H, Yang H, Luo K. Zebrafish live imaging reveals only around 2% rather than 50% of motor neurons die through apoptosis during development. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.26.577434.

Leucine-rich repeat in polycystin-1 suppresses cystogenesis in a zebrafish (Danio rerio) model of autosomal dominant polycystic kidney disease

Authors:
Padhy B, Amir M, Xie J, Huang C
Citation:
Preprints. 2024;2024011959 [preprint]. doi:10.20944/preprints202401.1959.v1
Epub:
Not Epub
Abstract:
Mutations of PKD1 coding for polycystin-1 (PC1) account for most of the autosomal dominant polycystic kidney disease (ADPKD)....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Padhy B, Amir M, Xie J, Huang C. Leucine-rich repeat in polycystin-1 suppresses cystogenesis in a zebrafish (Danio rerio) model of autosomal dominant polycystic kidney disease. Preprints. 2024;2024011959 [preprint]. doi:10.20944/preprints202401.1959.v1.

Characterization of CD90/Thy-1 as a crucial molecular signature for myogenic differentiation in human urine-derived cells through single-cell RNA sequencing

Authors:
Kunitake K, Motohashi N, Inoue T, Suzuki Y, Aoki Y
Citation:
Sci Rep. 2024 Jan 28;14(1):2329. doi: 10.1038/s41598-024-52530-5
Epub:
Not Epub
Abstract:
Human urine-derived cells (UDCs) are primary cultured cells originating from the upper urinary tract and are known to be...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: Human CD90-positive MYOD1-urine-derived cells
Citation Extract:
Kunitake K, Motohashi N, Inoue T, Suzuki Y, Aoki Y. Characterization of CD90/Thy-1 as a crucial molecular signature for myogenic differentiation in human urine-derived cells through single-cell RNA sequencing. Sci Rep. 2024 Jan 28;14(1):2329. doi: 10.1038/s41598-024-52530-5.

A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish

Authors:
Ikeuchi M, Inoue M, Miyahara H, Sebastian WA, Miyazaki S, Takeno T, Kiyota K, Yano S, Shiraishi H, Shimizu N, Hanada R, Yoshimura A, Ihara K, Hanada T
Citation:
Biochem Biophys Res Commun. 2024 Jan 19;699:149551. doi: 10.1016/j.bbrc.2024.149551. Online ahead of print
Epub:
Not Epub
Abstract:
V-ATPase is an ATP hydrolysis-driven proton pump involved in the acidification of intracellular organelles and systemic acid-...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ikeuchi M, Inoue M, Miyahara H, Sebastian WA, Miyazaki S, Takeno T, Kiyota K, Yano S, Shiraishi H, Shimizu N, Hanada R, Yoshimura A, Ihara K, Hanada T. A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish. Biochem Biophys Res Commun. 2024 Jan 19;699:149551. doi: 10.1016/j.bbrc.2024.149551. Online ahead of print.

Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity

Authors:
Anzell AR, Kunz AB, Donovan JP, Tran TG, Lu X, Young S, Roman BL
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.25.576046
Epub:
Not Epub
Abstract:
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease characterized by the development of arteriovenous...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Anzell AR, Kunz AB, Donovan JP, Tran TG, Lu X, Young S, Roman BL. Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.25.576046.

Systemic delivery of a splice-switching oligonucleotide heteroduplex corrects splicing in central nervous system and muscle in spinal muscular atrophy mice

Authors:
Halloy F, Ahlskog N, Wood M
Citation:
bioRxiv. 2024;[preprint] doi:10.1101/2024.01.24.577012
Epub:
Not Epub
Abstract:
Oligonucleotide therapeutics are an established class of drugs for the treatment of genetic disorders. Their clinical...
Delivery Method:
heteroduplex oligonucleotide (HDO) platform
Organism or Cell Type:
cell culture: SMA Type II patient fibroblasts, hSMN2 mouse
Citation Extract:
Halloy F, Ahlskog N, Wood M. Systemic delivery of a splice-switching oligonucleotide heteroduplex corrects splicing in central nervous system and muscle in spinal muscular atrophy mice. bioRxiv. 2024;[preprint] doi:10.1101/2024.01.24.577012.

Perturbed development of calb2b expressing dI6 interneurons and motor neurons underlies locomotor defects observed in calretinin knock-down zebrafish larvae

Authors:
Gonzalez ABI, Koning HK, Tuz-Sasik MU, van Osselen I, Manuel R, Boije H
Citation:
Dev Biol. 2024;508:77-87. doi:10.1016/j.ydbio.2024.01.001
Epub:
Not Epub
Abstract:
Calcium binding proteins are essential for neural development and cellular activity. Calretinin, encoded by calb2a and calb2b,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gonzalez ABI, Koning HK, Tuz-Sasik MU, van Osselen I, Manuel R, Boije H. Perturbed development of calb2b expressing dI6 interneurons and motor neurons underlies locomotor defects observed in calretinin knock-down zebrafish larvae. Dev Biol. 2024;508:77-87. doi:10.1016/j.ydbio.2024.01.001.

An anti-sense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo

Authors:
Damacena de Angelis C, Meddeb M, Chen N, Fisher SA
Citation:
Am J Physiol Heart Circ Physiol. 2024 Jan 26. doi: 10.1152/ajpheart.00745.2023. Online ahead of print
Epub:
Yes
Abstract:
Targeting alternative exons for therapeutic gain has been achieved in a few instances and potentially could be applied more...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Damacena de Angelis C, Meddeb M, Chen N, Fisher SA. An anti-sense oligonucleotide efficiently suppresses splicing of an alternative exon in vascular smooth muscle in vivo. Am J Physiol Heart Circ Physiol. 2024 Jan 26. doi: 10.1152/ajpheart.00745.2023. Online ahead of print.

Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring

Authors:
Chatterje B, Fatima F, Seth S, Sinha Roy S
Citation:
Cells. 2024;13:214. doi:10.3390/cells13030214
Epub:
Not Epub
Abstract:
Elevation of the intermediate amino acid metabolite Homocysteine (Hcy) causes Hyperhomocysteinemia (HHcy), a metabolic disorder...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chatterje B, Fatima F, Seth S, Sinha Roy S. Moderate Elevation of Homocysteine Induces Endothelial Dysfunction through Adaptive UPR Activation and Metabolic Rewiring. Cells. 2024;13:214. doi:10.3390/cells13030214.

TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish

Authors:
Van Schoor E, Strubbe D, Braems E, Weishaupt J, Ludolph A, Van Damme P, Thal DR, Bercier V, Van Den Bosch L
Citation:
Front Cell Neurosci. 2024;18:[Epub] doi:10.3389/fncel.2024.1340240
Epub:
Yes
Abstract:
Disease-associated variants of TUBA4A (alpha-tubulin 4A) have recently been identified in familial ALS. Interestingly, a...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Van Schoor E, Strubbe D, Braems E, Weishaupt J, Ludolph A, Van Damme P, Thal DR, Bercier V, Van Den Bosch L. TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish. Front Cell Neurosci. 2024;18:[Epub] doi:10.3389/fncel.2024.1340240.

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