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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12353 scientific papers returned from the database with the search filters currently being used below.
There are 12353 scientific papers returned from the database with the search filters currently being used below.
Novel MYH10 heterozygous variants associated to a syndrome combining mainly ptosis and ocular coloboma expand the MYH10 related phenotypes
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Citation:
Eur J Hum Genet. 2025 Mar 5. doi: 10.1038/s41431-025-01803-2. Epub ahead of print. PMID: 40044823 Epub:
Not Epub Abstract:
Syndromes associating both eyeball and periocular developmental anomalies, combining iris chorioretinal (ocular) coloboma and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Scheidecker S, Bär S, Kröll-Hermi A, Delvallée C, Rinaldi B, Korpioja A, Geoffroy V, Schaefer E, Secula S, Jaeger C, Stoetzel C, Kassel O, Straehle U, Bertoli-Avella A, Zonic E, Lamouche JB, Zanlonghi X, Etard C, Muller J, Rahikkala E, Friant S, Dollfus H. Novel MYH10 heterozygous variants associated to a syndrome combining mainly ptosis and ocular coloboma expand the MYH10 related phenotypes. Eur J Hum Genet. 2025 Mar 5. doi: 10.1038/s41431-025-01803-2. Epub ahead of print. PMID: 40044823. |
Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo
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Citation:
J Med Chem. 2025 Mar 7. doi: 10.1021/acs.jmedchem.4c02275. Epub ahead of print. PMID: 40052708 Epub:
Not Epub Abstract:
To increase the chemical space around the well-known GalNAc-ligand as ASGPR-binder, a high-throughput screening campaign was... Citation Extract: Hofmeister A, Jahn-Hofmann K, Brunner B, Helms M, Metz-Weidmann C, Poeverlein C, Zech G, Li Z, Hessler G, Schreuder H, Elshorst B, Krack A, Kurz M, Heubel C, Scheidler S. Trivalent siRNA-Conjugates with Guanosine as ASGPR-Binder Show Potent Knock-Down In Vivo. J Med Chem. 2025 Mar 7. doi: 10.1021/acs.jmedchem.4c02275. Epub ahead of print. PMID: 40052708. |
Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells
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Citation:
Mol Ther Nucleic Acids. 2024 Dec 21;36(1):102443. doi: 10.1016/j.omtn.2024.102443. PMID: 39967852; PMCID: PMC11834094 Epub:
Not Epub Abstract:
Dysferlinopathies are debilitating autosomal recessive muscular dystrophies caused by mutations in the DYSF gene, encoding... Delivery Method:
Endo-Porter Organism or Cell Type:
patient-derived myoblasts and differentiated myotubes Citation Extract: Anwar S, Roshmi RR, Woo S, Haque US, Arthur Lee JJ, Duddy WJ, Bigot A, Maruyama R, Yokota T. Antisense oligonucleotide-mediated exon 27 skipping restores dysferlin function in dysferlinopathy patient-derived muscle cells. Mol Ther Nucleic Acids. 2024 Dec 21;36(1):102443. doi: 10.1016/j.omtn.2024.102443. PMID: 39967852; PMCID: PMC11834094. |
Human colonic EVs induce murine enteric neuroplasticity via the lncRNA GAS5/miR-23/NMDA NR2B axis
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Citation:
JCI Insight. 2025 Mar 10;10(5):e178631. doi: 10.1172/jci.insight.178631. PMID: 40059833 Epub:
Not Epub Abstract:
Postinfectious, diarrhea-predominant, irritable bowel syndrome (PI-IBS-D) is difficult to treat owing to its unknown... Delivery Method:
Vivo-Morpholino; intraperitoneal (i.p.) Organism or Cell Type:
Rab27a/b–/– mice Citation Extract: Zhou Q, Yang L, Verne ZT, Zhang BB, Fields JZ, Thacker AT, Verne GN. Human colonic EVs induce murine enteric neuroplasticity via the lncRNA GAS5/miR-23/NMDA NR2B axis. JCI Insight. 2025 Mar 10;10(5):e178631. doi: 10.1172/jci.insight.178631. PMID: 40059833. |
Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway
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Citation:
Mol Neurodegener. 2025 Mar 5;20(1):28. doi: 10.1186/s13024-025-00807-2. PMID: 40045384; PMCID: PMC11883989 Epub:
Not Epub Abstract:
Background: Axon regeneration within the mammalian central nervous system is extremely limited. In optic neuropathy conditions... Delivery Method:
gel foam soaked in MO placed on distal optic nerve stump Organism or Cell Type:
zebrafish Citation Extract: Hu M, Veldman MB. Srebf2 mediates successful optic nerve axon regeneration via the mevalonate synthesis pathway. Mol Neurodegener. 2025 Mar 5;20(1):28. doi: 10.1186/s13024-025-00807-2. PMID: 40045384; PMCID: PMC11883989. |
Protein-O-fucosylation of co-receptors may be required for Nodal signaling in Xenopus
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Citation:
Mol Cells. 2025 Mar 3:100207. doi: 10.1016/j.mocell.2025.100207. Epub ahead of print. PMID: 40043779 Epub:
Not Epub Abstract:
Nodal-related ligands of TGF-β family play pivotal roles for mesoderm induction and body axis formation during vertebrate early... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Kim YJ, Nho SJ, Lee SY, Yeo CY. Protein-O-fucosylation of co-receptors may be required for Nodal signaling in Xenopus. Mol Cells. 2025 Mar 3:100207. doi: 10.1016/j.mocell.2025.100207. Epub ahead of print. PMID: 40043779. |
mRNA splicing variants of the transcription factor Blimp1 differentially regulate germline genes in echinoderms
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Citation:
Dev Biol. 2025 Feb 28:S0012-1606(25)00054-5 Epub:
Not Epub Abstract:
Germ cell specification is an essential step in sexually reproducing animals. Echinoderms possess diverse representatives of... Delivery Method:
microinjection Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin), Patiria miniata (sea star) Citation Extract: Reyes G, Oulhen N, Wessel G. mRNA splicing variants of the transcription factor Blimp1 differentially regulate germline genes in echinoderms. Dev Biol. 2025 Feb 28:S0012-1606(25)00054-5. |
RPS24 haploinsufficiency impairs erythropoiesis in the Diamond-Blackfan anemia zebrafish model via the STAT6-SATB1 pathway
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Citation:
Biochem Biophys Res Commun. 2025 Apr 5;756:151563. doi: 10.1016/j.bbrc.2025.151563. Epub 2025 Mar 1. PMID: 40054062 Epub:
Not Epub Abstract:
Diamond-Blackfan anemia (DBA) is a rare bone marrow failure disorder primarily caused by mutations in ribosomal proteins (RPs... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ahn S, Oh CK. R. RPS24 haploinsufficiency impairs erythropoiesis in the Diamond-Blackfan anemia zebrafish model via the STAT6-SATB1 pathway. Biochem Biophys Res Commun. 2025 Apr 5;756:151563. doi: 10.1016/j.bbrc.2025.151563. Epub 2025 Mar 1. PMID: 40054062. |
Phosphorodiamidate Morpholino Oligomers-Loaded Nanobubbles for Ultrasound-Mediated Delivery to the Myocardium in Muscular Dystrophy
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Citation:
ACS Omega Article ASAP. doi: 10.1021/acsomega.4c10896 Epub:
Not Epub Abstract:
Microbubbles (MBs) and nanobubbles (NBs) can oscillate and collapse in response to ultrasound exposure, resulting in contrast... Delivery Method:
R8 peptide-linked; intravenous (i.v.) injection Organism or Cell Type:
mice: C57BL/10ScSnmdx Citation Extract: Endo-Takahashi Y, Sakurai A, Oguri Y, Katagiri F, Akiyama S, Sashida S, Yamaguchi T, Marunouchi T, Suzuki R, Maruyama K, Tanonaka K, Nomizu M, Negishi Y. Phosphorodiamidate Morpholino Oligomers-Loaded Nanobubbles for Ultrasound-Mediated Delivery to the Myocardium in Muscular Dystrophy. ACS Omega Article ASAP. doi: 10.1021/acsomega.4c10896. |
Optochemical control over mRNA translation by photocaged phosphorodiamidate morpholino oligonucleotides in vivo
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Citation:
Nat Commun 16, 3614 (2025). https://doi.org/10.1038/s41467-025-58207-5 Epub:
Not Epub Abstract:
A key regulatory step in protein synthesis is the initiation of mRNA translation. We developed an efficient, robust, and... Delivery Method:
microinjection, UV-photocleavable Morpholino Organism or Cell Type:
zebrafish Citation Extract: Tarbashevich K, Ghosh A, Das A, Kuilya D, Shrama SN, Sinha S, Raz E. Optochemical control over mRNA translation by photocaged phosphorodiamidate morpholino oligonucleotides in vivo. Nat Commun 16, 3614 (2025). https://doi.org/10.1038/s41467-025-58207-5. |