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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11377 scientific papers returned from the database with the search filters currently being used below.

Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease

Authors:
Doccini S, Marchese M, Morani F, Gammaldi N, Mero S, Pezzini F, Soliymani R, Santi M, Signore G, Ogi A, Rocchiccioli S, Kanninen KM, Simonati A, Lalowski MM, Santorelli FM
Citation:
Cells. 2022;11:1840. doi:10.3390/cells11111840
Epub:
Not Epub
Abstract:
CLN5 disease (MIM: 256731) represents a rare late-infantile form of neuronal ceroid lipofuscinosis (NCL), caused by mutations...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Doccini S, Marchese M, Morani F, Gammaldi N, Mero S, Pezzini F, Soliymani R, Santi M, Signore G, Ogi A, Rocchiccioli S, Kanninen KM, Simonati A, Lalowski MM, Santorelli FM. Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease. Cells. 2022;11:1840. doi:10.3390/cells11111840.

U1 snRNP suppresses microRNA biogenesis by alternative intronic polyadenylation in melanoma

Authors:
Vorlova S, Blahetek G, Barbieri R, Kerstan Y, Rosa A, Bundalo M, Egg M, Butt E, Henke E, Dölken L, Houben R, Schilling B, Fischer U, Erhard F, Zernecke A
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.06.01.479622
Epub:
Not Epub
Abstract:
Activation of intronic polyadenylation signals results in premature cleavage and polyadenylation (PCPA). The majority of...
Delivery Method:
Vivo-Morpholino Endo-Porter
Organism or Cell Type:
cell culture: UACC-257, HeLe
Citation Extract:
Vorlova S, Blahetek G, Barbieri R, Kerstan Y, Rosa A, Bundalo M, Egg M, Butt E, Henke E, Dölken L, Houben R, Schilling B, Fischer U, Erhard F, Zernecke A. U1 snRNP suppresses microRNA biogenesis by alternative intronic polyadenylation in melanoma. bioRxiv. 2022;[preprint] doi:10.1101/2022.06.01.479622.

Ultrasensitive Detection of Exosomal miRNA with PMO- Graphene Quantum Dots Functionalized Field Effect Transistor Biosensor

Authors:
Li K, Tu J, Zhang Y, Jin D, Li T, Li J, Ni W, Xiao M-M, Zhang Z-Y, Zhang G-J
Citation:
iScience. 2022;[Epub] doi:10.1016/j.isci.2022.104522
Epub:
Not Epub
Abstract:
Compared to the conventional DNA probe immobilization on the planar surface, nanoparticles-based DNA probes enable more RNA...
Citation Extract:
Li K, Tu J, Zhang Y, Jin D, Li T, Li J, Ni W, Xiao M-M, Zhang Z-Y, Zhang G-J. Ultrasensitive Detection of Exosomal miRNA with PMO- Graphene Quantum Dots Functionalized Field Effect Transistor Biosensor. iScience. 2022;[Epub] doi:10.1016/j.isci.2022.104522.

Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord

Authors:
Sánchez-Iranzo H, Halavatyi A, Diz-Muñoz A
Citation:
eLife. 2022;11:e75429. doi:10.7554/eLife.75429
Epub:
Not Epub
Abstract:
Development of multicellular organisms requires the generation of gene expression patterns that determines cell fate and organ...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sánchez-Iranzo H, Halavatyi A, Diz-Muñoz A. Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord. eLife. 2022;11:e75429. doi:10.7554/eLife.75429.

Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy

Authors:
Hashimoto Y, Kuniishi H, Sakai K, Fukushima Y, Du X, Yamashiro K, Hori K, Imamura M, Hoshino M, Yamada M, Araki T, Sakagami H, Takeda S, Itaka K, Ichinohe N, Muntoni F, Sekiguchi M, Aoki Y
Citation:
Prog Neurobiol. 2022 May 30:102288. doi: 10.1016/j.pneurobio.2022.102288. Online ahead of print
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a muscle disorder caused by DMD mutations and is characterized by neurobehavioural...
Delivery Method:
i.c.v. intracerebroventricular infusion
Organism or Cell Type:
mice
Citation Extract:
Hashimoto Y, Kuniishi H, Sakai K, Fukushima Y, Du X, Yamashiro K, Hori K, Imamura M, Hoshino M, Yamada M, Araki T, Sakagami H, Takeda S, Itaka K, Ichinohe N, Muntoni F, Sekiguchi M, Aoki Y. Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy. Prog Neurobiol. 2022 May 30:102288. doi: 10.1016/j.pneurobio.2022.102288. Online ahead of print.

Perfluorooctane Sulfonamide (PFOSA) Induces Cardiotoxicity via Aryl Hydrocarbon Receptor Activation in Zebrafish

Authors:
Chen H, Qiu W, Yang X, Chen F, Chen J, Tang L, Zhong H, Magnuson JT, Zheng C, Xu EG
Citation:
Environ Sci Technol. 2022 Jun 2. doi: 10.1021/acs.est.1c08875. Online ahead of print
Epub:
Not Epub
Abstract:
Perfluorooctane sulfonamide (PFOSA), a precursor of perfluorooctanesulfonate (PFOS), is widely used during industrial processes...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen H, Qiu W, Yang X, Chen F, Chen J, Tang L, Zhong H, Magnuson JT, Zheng C, Xu EG. Perfluorooctane Sulfonamide (PFOSA) Induces Cardiotoxicity via Aryl Hydrocarbon Receptor Activation in Zebrafish. Environ Sci Technol. 2022 Jun 2. doi: 10.1021/acs.est.1c08875. Online ahead of print.

Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue

Authors:
Scripture-Adams DD, Chesmore KN, Barthélémy F, Wang RT, Nieves-Rodriguez S, Wang DW, Mokhonova EI, Douine ED, Wan J, Little I, Rabichow LN, Nelson SF, Miceli MC
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.05.31.494197
Epub:
Not Epub
Abstract:
In Duchenne muscular dystrophy, dystrophin loss leads to chronic muscle damage, dysregulation of repair, fibro-fatty...
Organism or Cell Type:
mice
Citation Extract:
Scripture-Adams DD, Chesmore KN, Barthélémy F, Wang RT, Nieves-Rodriguez S, Wang DW, Mokhonova EI, Douine ED, Wan J, Little I, Rabichow LN, Nelson SF, Miceli MC. Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue. bioRxiv. 2022;[preprint] doi:10.1101/2022.05.31.494197 .

Cholesterol Accumulation in Livers of Indian Medaka, Oryzias dancena, Acclimated to Fresh Water and Seawater

Authors:
Ranasinghe N, Lin C-H, Lee T-H
Citation:
Front Mar Sci. 2022;9:{Epub] doi:10.3389/fmars.2022.891706
Epub:
Yes
Abstract:
Sterol regulatory-element binding proteins (SREBPs), sirtuin (SIRT1), and liver X receptor α (LXRα) play important roles in...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Oryzias dancena (Indian medaka)
Citation Extract:
Ranasinghe N, Lin C-H, Lee T-H. Cholesterol Accumulation in Livers of Indian Medaka, Oryzias dancena, Acclimated to Fresh Water and Seawater. Front Mar Sci. 2022;9:{Epub] doi:10.3389/fmars.2022.891706.

Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors

Authors:
Li R-F, Wang Y-S, Lu F-I, Huang Y-S, Chiu C-C, Tai M-H, Wu C-Y
Citation:
Biomedicines. 2022;10(6):1261. doi:/10.3390/biomedicines10061261
Epub:
Not Epub
Abstract:
The genetic regulation of vascular development is not elucidated completely. We previously characterized the transcription...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li R-F, Wang Y-S, Lu F-I, Huang Y-S, Chiu C-C, Tai M-H, Wu C-Y. Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors. Biomedicines. 2022;10(6):1261. doi:/10.3390/biomedicines10061261.

A Strategy for Gene Knockdown in Dinoflagellates

Authors:
Judd M, Place AR
Citation:
Microorganisms. 2022;10:1131. doi:10.3390/microorganisms10061131
Epub:
Not Epub
Abstract:
Dinoflagellates are unicellular protists that display unusual nuclear features such as large genomes, condensed chromosomes and...
Delivery Method:
Endo-Porter
Organism or Cell Type:
Amphidinium carterae (dinoflagellate)
Citation Extract:
Judd M, Place AR. A Strategy for Gene Knockdown in Dinoflagellates. Microorganisms. 2022;10:1131. doi:10.3390/microorganisms10061131.

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