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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10468 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Tension heterogeneity directs form and fate to pattern the myocardial wall

Authors:
Priya R, Allanki S, Gentile A, Mansingh S, Uribe V, Maischein H-M, Stainier DYR
Citation:
Nature. 2020;[Epub ahead of print] doi:10.1038/s41586-020-2946-9
Abstract:
How diverse cell fates and complex forms emerge and feed back to each other to sculpt functional organs remains unclear. In the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Priya R, Allanki S, Gentile A, Mansingh S, Uribe V, Maischein H-M, Stainier DYR. Tension heterogeneity directs form and fate to pattern the myocardial wall. Nature. 2020;[Epub ahead of print] doi:10.1038/s41586-020-2946-9.

RNaseH-mediated simultaneous piggyback knockdown of multiple genes in adult zebrafish

Authors:
Raman R, Ryon M, Jagadeeswaran P
Citation:
Sci Rep. 2020;10:20187 doi:10.1038/s41598-020-76655-5
Abstract:
We recently developed a piggyback knockdown method that was used to knockdown genes in adult zebrafish. In this method, a vivo...
Delivery Method:
Vivo-Morpholino (piggyback )
Organism or Cell Type:
zebrafish
Citation Extract:
Raman R, Ryon M, Jagadeeswaran P. RNaseH-mediated simultaneous piggyback knockdown of multiple genes in adult zebrafish. Sci Rep. 2020;10:20187 doi:10.1038/s41598-020-76655-5.

Cytoskeletal Protein Zyxin Inhibits the Activity of Genes Responsible for Embryonic Stem Cell Status

Authors:
Parshina EA, Eroshkin FM, Оrlov EE, Gyoeva FK, Shokhina AG, Staroverov DB, Belousov VV, Zhigalova NA, Prokhortchouk EB, Zaraisky AG, Martynova NY
Citation:
Cell Rep. 2020;33(7):108396. doi:10.1016/j.celrep.2020.108396
Abstract:
Zyxin is a cytoskeletal LIM-domain protein that regulates actin cytoskeleton assembly and gene expression. In the present work...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis and zebrafish
Citation Extract:
Parshina EA, Eroshkin FM, Оrlov EE, Gyoeva FK, Shokhina AG, Staroverov DB, Belousov VV, Zhigalova NA, Prokhortchouk EB, Zaraisky AG, Martynova NY. Cytoskeletal Protein Zyxin Inhibits the Activity of Genes Responsible for Embryonic Stem Cell Status. Cell Rep. 2020;33(7):108396. doi:10.1016/j.celrep.2020.108396.

Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression

Authors:
Wu CS, Lu YF, Liu YH, Huang CJ, Hwang SL
Citation:
Dev Biol. 2020 Nov 13:S0012-1606(20)30293-1. doi: 10.1016/j.ydbio.2020.11.001. Online ahead of print
Abstract:
Nodal signaling is essential for mesoderm and endoderm formation, as well as neural plate induction and establishment of left-...
Delivery Method:
microinjection, Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Wu CS, Lu YF, Liu YH, Huang CJ, Hwang SL. Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression. Dev Biol. 2020 Nov 13:S0012-1606(20)30293-1. doi: 10.1016/j.ydbio.2020.11.001. Online ahead of print.

GJA1 Depletion Causes Ciliary Defects by Affecting Rab11 Trafficking to the Ciliary Base

Authors:
Jang DG, Kwon KY, Kweon YC, Kim B-g, Myung K, Lee H-S, Park CY, Kwon T, Park TJ
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.11.13.381764
Abstract:
The gap junction complex functions as a transport channel across the membrane. Among gap junction subunits, gap junction...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Jang DG, Kwon KY, Kweon YC, Kim B-g, Myung K, Lee H-S, Park CY, Kwon T, Park TJ. GJA1 Depletion Causes Ciliary Defects by Affecting Rab11 Trafficking to the Ciliary Base. bioRxiv. 2020;[preprint] doi:10.1101/2020.11.13.381764 .

Pcdh18a-positive tip cells instruct notochord formation in zebrafish

Authors:
Bosze B, Mattes B, Sinner C, Stricker K, Gourain V, Thumberger T, Tlili S, Weber S, Wittbrodt J, Saunders TE, Strähle U, Schug A, Scholpp S
Citation:
bioRxiv. 2018;[preprint] doi:10.1101/257717
Abstract:
The notochord defines the axial structure of all vertebrates during development. Notogenesis is a result of major cell...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bosze B, Mattes B, Sinner C, Stricker K, Gourain V, Thumberger T, Tlili S, Weber S, Wittbrodt J, Saunders TE, Strähle U, Schug A, Scholpp S. Pcdh18a-positive tip cells instruct notochord formation in zebrafish. bioRxiv. 2018;[preprint] doi:10.1101/257717.

RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis

Authors:
Farooq M, Lindbæk L, Krogh N, Doganli C, Keller C, Mönnich M, Gonçalves AB, Sakthivel S, Mang Y, Fatima A, Andersen VS, Hussain MS, Eiberg H, Hansen L, Kjaer KW, Gopalakrishnan J, Pedersen LB, Møllgård K, Nielsen H, Baig SM, Tommerup N, Christensen ST, Larsen LA
Citation:
Nat Commun. 2020;11:5816 doi:10.1038/s41467-020-19658-0
Abstract:
Primary microcephaly (MCPH) is characterized by reduced brain size and intellectual disability. The exact pathophysiological...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Farooq M, Lindbæk L, Krogh N, Doganli C, Keller C, Mönnich M, Gonçalves AB, Sakthivel S, Mang Y, Fatima A, Andersen VS, Hussain MS, Eiberg H, Hansen L, Kjaer KW, Gopalakrishnan J, Pedersen LB, Møllgård K, Nielsen H, Baig SM, Tommerup N, Christensen ST, Larsen LA. RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis. Nat Commun. 2020;11:5816 doi:10.1038/s41467-020-19658-0.

Investigating the effect of DMD non-sequential splicing on exon skipping strategies

Authors:
Goossens R, Verwey N, Schnell F, Aartsma-Rus A
Citation:
Neuromuscul Disord. 2020;30(Suppl 1):S128-S129. P.281 doi:10.1016/j.nmd.2020.08.278
Abstract:
Duchenne muscular dystrophy is one of the most common myopathies, with an incidence of 1:5000 in new-born boys. The root cause...
Organism or Cell Type:
cell culture: myocytes
Citation Extract:
Goossens R, Verwey N, Schnell F, Aartsma-Rus A. Investigating the effect of DMD non-sequential splicing on exon skipping strategies. Neuromuscul Disord. 2020;30(Suppl 1):S128-S129. P.281 doi:10.1016/j.nmd.2020.08.278.

Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration.

Authors:
Cui J, Chen G, Wen D, Wang Y, Zhao Z, Wu C
Citation:
Front Cell Infect Microbiol. 2020 Oct 29;10:519503. doi: 10.3389/fcimb.2020.519503
Abstract:
The ADP ribosylation factor (ARF) GTPase activation protein ASAP1 possesses multiple biological functions, including regulation...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cui J, Chen G, Wen D, Wang Y, Zhao Z, Wu C. Asap1 Affects the Susceptibility of Zebrafish to Mycobacterium by Regulating Macrophage Migration.. Front Cell Infect Microbiol. 2020 Oct 29;10:519503. doi: 10.3389/fcimb.2020.519503.

The Caudal ParaHox gene is required for hindgut development in the mollusc Tritia (a.k.a. Ilyanassa)

Authors:
Johnson AB, Lambert JD
Citation:
Dev Biol. 2020 Oct 24;470:1-9. doi: 10.1016/j.ydbio.2020.10.010. Online ahead of print
Abstract:
Caudal homeobox genes are found across animals, typically linked to two other homeobox genes in what has been called the...
Organism or Cell Type:
Tritia obsoleta (previously Ilyanassa obsoleta) gastropod
Citation Extract:
Johnson AB, Lambert JD. The Caudal ParaHox gene is required for hindgut development in the mollusc Tritia (a.k.a. Ilyanassa). Dev Biol. 2020 Oct 24;470:1-9. doi: 10.1016/j.ydbio.2020.10.010. Online ahead of print.

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