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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12570 scientific papers returned from the database with the search filters currently being used below.

The neuropathy-linked protein TECPR2 is a Rab5 effector that regulates cargo recycling from early endosomes

Authors:
Paul S, Pant R, Sharma P, Walia K, Gupta S, Aseem A, Bajwa KK, George R, Varma Y, Bhatia T, Ramachandran R, Tuli A, Sharma M
Citation:
Nat Commun. 2025 Nov 26;16(1):10537. doi: 10.1038/s41467-025-65568-4. PMID: 41298403; PMCID: PMC12658116
Epub:
Not Epub
Abstract:
Small GTP-binding proteins of the Rab, Arf, and Arf-like family mediate the recruitment of their effectors to subcellular...
Link:
https://www.nature.com/articles/s41467-025-65568-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Paul S, Pant R, Sharma P, Walia K, Gupta S, Aseem A, Bajwa KK, George R, Varma Y, Bhatia T, Ramachandran R, Tuli A, Sharma M. The neuropathy-linked protein TECPR2 is a Rab5 effector that regulates cargo recycling from early endosomes. Nat Commun. 2025 Nov 26;16(1):10537. doi: 10.1038/s41467-025-65568-4. PMID: 41298403; PMCID: PMC12658116.

Machine learning-driven glycolytic subtyping and exosome-based PKM splicing modulation overcome drug resistance in hyper-glycolytic myeloid leukemia

Authors:
Zhong F, Chen S, Yao F, Liu J, Zhang J, Jiang J, Bai Q, Wang Z, Zhang L, Liu L, Jiang X, Huo S, Wang X, Huang B
Citation:
npj Digit. Med. (2025). https://doi.org/10.1038/s41746-025-02185-x
Epub:
Not Epub
Abstract:
This study comprehensively investigates the role of glycolysis in acute myeloid leukemia (AML) pathogenesis. Elevated...
Link:
https://www.nature.com/articles/s41746-025-02185-x
Delivery Method:
exosome-loaded Vivo-Morpholino; intratumoral (i.t.) or intravenous (i.v.) injection
Organism or Cell Type:
chronic myeloid leukemia xenograft
Citation Extract:
Zhong F, Chen S, Yao F, Liu J, Zhang J, Jiang J, Bai Q, Wang Z, Zhang L, Liu L, Jiang X, Huo S, Wang X, Huang B. Machine learning-driven glycolytic subtyping and exosome-based PKM splicing modulation overcome drug resistance in hyper-glycolytic myeloid leukemia. npj Digit. Med. (2025). https://doi.org/10.1038/s41746-025-02185-x.

Production of offspring via the transplantation of frozen germ cells from Tokyo bitterling, a fish on the brink of extinction

Authors:
Yamakawa K, Kawaguchi K, Yoshizaki G
Citation:
Sci Rep. 2025 Nov 19;15(1):40759. doi: 10.1038/s41598-025-24449-y. PMID: 41258175; PMCID: PMC12630933
Epub:
Not Epub
Abstract:
Many freshwater fish face extinctions due to habitat destruction and overfishing. Bitterlings, which lay their eggs in the gill...
Link:
https://www.nature.com/articles/s41598-025-24449-y
Delivery Method:
microinjection
Organism or Cell Type:
Tokyo bitterling
Citation Extract:
Yamakawa K, Kawaguchi K, Yoshizaki G. Production of offspring via the transplantation of frozen germ cells from Tokyo bitterling, a fish on the brink of extinction. Sci Rep. 2025 Nov 19;15(1):40759. doi: 10.1038/s41598-025-24449-y. PMID: 41258175; PMCID: PMC12630933.

Dual origins for neural cells during development of the Clytia planula larva

Authors:
Ruggiero A, Ferraioli A, Chevalier S, Lapébie P, Girard R, Momose T, Barreau C, Houliston E
Citation:
bioRxiv [preprint] 2025.11.17.688882; doi: https://doi.org/10.1101/2025.11.17.688882
Epub:
Not Epub
Abstract:
Adult hydrozoan cnidarians undergo extensive tissue turnover, generating neural cell types including nematocytes (stinging...
Link:
https://www.biorxiv.org/content/10.1101/2025.11.17.688882v1
Delivery Method:
microinjection
Organism or Cell Type:
Clytia (Phialidium) gregarium gastrula-stage embryos
Citation Extract:
Ruggiero A, Ferraioli A, Chevalier S, Lapébie P, Girard R, Momose T, Barreau C, Houliston E. Dual origins for neural cells during development of the Clytia planula larva. bioRxiv [preprint] 2025.11.17.688882; doi: https://doi.org/10.1101/2025.11.17.688882.

Collagen processing is essential for germ cell identity

Authors:
Roman S, Oulhen N, Reyes G, Masina B, Wessel G
Citation:
Biol Open. 2025 Nov 15;14(11):bio062198. doi: 10.1242/bio.062198. Epub 2025 Nov 20. PMID: 41263153
Epub:
Not Epub
Abstract:
The extracellular matrix (ECM) is a critical component of embryonic development, providing both structural support and a...
Link:
https://journals.biologists.com/bio/article/14/11/bio062198/369875/Collagen-processing-is-essential-for-germ-cell
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Roman S, Oulhen N, Reyes G, Masina B, Wessel G. Collagen processing is essential for germ cell identity. Biol Open. 2025 Nov 15;14(11):bio062198. doi: 10.1242/bio.062198. Epub 2025 Nov 20. PMID: 41263153.

DNA methyltransferase Dnmt3ba-mediated epigenetic modulation of Integrin signaling is essential for hematopoietic stem and progenitor cell development

Authors:
Ai K, Wu Y, Liang G, Kong H, Yang X, Li N, Liu Z, Dong Y, Xu J, Zhang L, Chen X, Fu Y, Wang L, Li L
Citation:
Commun Biol. 2025 Nov 19;8(1):1612. doi: 10.1038/s42003-025-09003-w. PMID: 41261168; PMCID: PMC12630766
Epub:
Not Epub
Abstract:
In vertebrate embryonic development, hematopoietic stem and progenitor cells (HSPCs) originate from a subset of arterial...
Link:
https://www.nature.com/articles/s42003-025-09003-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ai K, Wu Y, Liang G, Kong H, Yang X, Li N, Liu Z, Dong Y, Xu J, Zhang L, Chen X, Fu Y, Wang L, Li L. DNA methyltransferase Dnmt3ba-mediated epigenetic modulation of Integrin signaling is essential for hematopoietic stem and progenitor cell development. Commun Biol. 2025 Nov 19;8(1):1612. doi: 10.1038/s42003-025-09003-w. PMID: 41261168; PMCID: PMC12630766.

A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology

Authors:
Sun J, Atiş IS, Empke SLL, Khokha MK, Breslow DK
Citation:
Dev Cell. 2025 Nov 20:S1534-5807(25)00666-5. doi: 10.1016/j.devcel.2025.10.015. Epub ahead of print. PMID: 41270742
Epub:
Not Epub
Abstract:
Microscopy offers an indispensable technique for visualizing biological processes and for defining cytological abnormalities...
Link:
https://www.cell.com/developmental-cell/fulltext/S1534-5807(25)00666-5
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Sun J, Atiş IS, Empke SLL, Khokha MK, Breslow DK. A microscopy-based CRISPR screening platform enables organellar functional genomics and illuminates ciliary biology. Dev Cell. 2025 Nov 20:S1534-5807(25)00666-5. doi: 10.1016/j.devcel.2025.10.015. Epub ahead of print. PMID: 41270742.

NF2 lacking exon 11 induced by antisense gene therapy is able to partially recover merlin deficiency on NF2-SWN iPSC-derived spheroid model

Authors:
Casals-Sendra G, Jarne-Sanz I, Catasús N, Boluda-Luis I, Quer A, Amilibia E, Lázaro C, Serra E, Blanco I, Castellanos E
Citation:
bioRxiv 2025.11.14.688164; doi: https://doi.org/10.1101/2025.11.14.688164
Epub:
Not Epub
Abstract:
NF2-related Schwannomatosis (NF2-SWN) is an inherited autosomal dominant disorder resulting from loss-of-function mutations in...
Link:
https://www.biorxiv.org/content/10.1101/2025.11.14.688164v1.full
Delivery Method:
Endo-Porter for iPSCs differentiated into neural crest (NC) spheroids, Vivo-Morpholino for Schwann cell spheroids differentiated from NC cells
Organism or Cell Type:
NF2-SWN patient-derived primary fibroblasts
Citation Extract:
Casals-Sendra G, Jarne-Sanz I, Catasús N, Boluda-Luis I, Quer A, Amilibia E, Lázaro C, Serra E, Blanco I, Castellanos E. NF2 lacking exon 11 induced by antisense gene therapy is able to partially recover merlin deficiency on NF2-SWN iPSC-derived spheroid model. bioRxiv 2025.11.14.688164; doi: https://doi.org/10.1101/2025.11.14.688164.

Zebrafish col4a1 loss-of-function models mirror key neurovascular and ocular features of COL4A1/A2 syndrome and enable human variants assessment in vivo

Authors:
Paradisi G, Bonavolontà V, Venditti M, Fasano G, Pedalino C, Bene FD, Tartaglia M, Lauri A
Citation:
Matrix Biol. 2025 Nov 15:S0945-053X(25)00108-8. doi: 10.1016/j.matbio.2025.11.004. Epub ahead of print. PMID: 41248836
Epub:
Not Epub
Abstract:
Pathogenic variants in COL4A1 and COL4A2, encoding type IV collagen α1 and α2 chains-core components of all basement membranes-...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0945053X25001088
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Paradisi G, Bonavolontà V, Venditti M, Fasano G, Pedalino C, Bene FD, Tartaglia M, Lauri A. Zebrafish col4a1 loss-of-function models mirror key neurovascular and ocular features of COL4A1/A2 syndrome and enable human variants assessment in vivo. Matrix Biol. 2025 Nov 15:S0945-053X(25)00108-8. doi: 10.1016/j.matbio.2025.11.004. Epub ahead of print. PMID: 41248836.

Sox8 is essential for vertebrate gastrulation

Authors:
Moreira S, Korovesi AG, Barriga EH
Citation:
EMBO Rep. 2025 Nov 10. doi: 10.1038/s44319-025-00617-z. Epub ahead of print. PMID: 41214364
Epub:
Not Epub
Abstract:
Gastrulation is a fundamental developmental process during which germ layers are formed and the body axes are defined by the...
Link:
https://www.embopress.org/doi/full/10.1038/s44319-025-00617-z
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Moreira S, Korovesi AG, Barriga EH. Sox8 is essential for vertebrate gastrulation. EMBO Rep. 2025 Nov 10. doi: 10.1038/s44319-025-00617-z. Epub ahead of print. PMID: 41214364.

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