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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12198 scientific papers returned from the database with the search filters currently being used below.

5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming

Authors:
Parasyraki E, Mallick M, Hatch V, Vastolo V, Musheev MU, Karaulanov E, Gopanenko A, Moxon S, Méndez-Lago M, Han D, Schomacher L, Mukherjee D, Niehrs C
Citation:
Cell. 2024 Aug 28:S0092-8674(24)00902-4. doi: 10.1016/j.cell.2024.08.011. Epub ahead of print. PMID: 39214079
Epub:
Not Epub
Abstract:
5-Methylcytosine (5mC) is an established epigenetic mark in vertebrate genomic DNA, but whether its oxidation intermediates...
Link:
https://www.cell.com/cell/abstract/S0092-8674(24)00902-4
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Parasyraki E, Mallick M, Hatch V, Vastolo V, Musheev MU, Karaulanov E, Gopanenko A, Moxon S, Méndez-Lago M, Han D, Schomacher L, Mukherjee D, Niehrs C. 5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming. Cell. 2024 Aug 28:S0092-8674(24)00902-4. doi: 10.1016/j.cell.2024.08.011. Epub ahead of print. PMID: 39214079.

Sequencing of Phosphorodiamidate Morpholino Oligomers by Hydrophilic Interaction Chromatography Coupled to Tandem Mass Spectrometry

Authors:
Wang M, O'Day B, Michaels B, Jurayj J, Cai BZ, Wei T
Citation:
J Am Soc Mass Spectrom. 2024 Oct 2;35(10):2490-2498. doi: 10.1021/jasms.4c00281. Epub 2024 Aug 30. PMID: 39213635
Epub:
Not Epub
Abstract:
Sequencing of phosphorodiamidate morpholino oligomers (PMOs) by hydrophilic interaction chromatography (HILIC) coupled to...
Link:
https://pubs.acs.org/doi/10.1021/jasms.4c00281
Citation Extract:
Wang M, O'Day B, Michaels B, Jurayj J, Cai BZ, Wei T. Sequencing of Phosphorodiamidate Morpholino Oligomers by Hydrophilic Interaction Chromatography Coupled to Tandem Mass Spectrometry. J Am Soc Mass Spectrom. 2024 Oct 2;35(10):2490-2498. doi: 10.1021/jasms.4c00281. Epub 2024 Aug 30. PMID: 39213635.

Structure-Activity Relationship of Antibody-Oligonucleotide Conjugates: Evaluating Bioconjugation Strategies for Antibody-Phosphorodiamidate Morpholino Oligomer Conjugates for Drug Development

Authors:
Cochran M, Marks I, Albin T, Arias D, Kovach P, Darimont B, Huang H, Etxaniz U, Kwon HW, Shi Y, Diaz M, Tyaglo O, Levin A, Doppalapudi VR
Citation:
J Med Chem. 2024 Aug 28. doi: 10.1021/acs.jmedchem.4c00803. Online ahead of print. PMID: 39197837
Epub:
Not Epub
Abstract:
Antibody–oligonucleotide conjugates (AOCs) are promising treatments for Duchenne muscular dystrophy (DMD). They work via...
Link:
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00803
Delivery Method:
antibody-linked; intravenous (i.v.)
Organism or Cell Type:
mice: ICR, C57BL/6, C57BL/10ScSn-Dmdmdx/J, C57BL/10ScSnJ
Citation Extract:
Cochran M, Marks I, Albin T, Arias D, Kovach P, Darimont B, Huang H, Etxaniz U, Kwon HW, Shi Y, Diaz M, Tyaglo O, Levin A, Doppalapudi VR. Structure-Activity Relationship of Antibody-Oligonucleotide Conjugates: Evaluating Bioconjugation Strategies for Antibody-Phosphorodiamidate Morpholino Oligomer Conjugates for Drug Development. J Med Chem. 2024 Aug 28. doi: 10.1021/acs.jmedchem.4c00803. Online ahead of print. PMID: 39197837.

Oncogenic Ras activation in permissive somatic cells triggers rapid onset phenotypic plasticity and elicits a tumour-promoting neutrophil response

Authors:
Elliot AM, Ribeiro Bravo I, Astorga Johansson J, Hutton E, Cunningham R, Myllymaki H, Chang KY, Cholewa-Waclaw J, Zhao Y, Dobie R, Beltran M, Lewis A, Elks P, Hansen CG, Henderson N, Feng Y
Citation:
bioRxiv [preprint] 2023.11.10.566547; doi: https://doi.org/10.1101/2023.11.10.566547
Epub:
Not Epub
Abstract:
Oncogenic driver mutations are frequently found in normal tissues, suggesting that additional non-genetic factors are required...
Link:
https://www.biorxiv.org/content/10.1101/2023.11.10.566547v2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Elliot AM, Ribeiro Bravo I, Astorga Johansson J, Hutton E, Cunningham R, Myllymaki H, Chang KY, Cholewa-Waclaw J, Zhao Y, Dobie R, Beltran M, Lewis A, Elks P, Hansen CG, Henderson N, Feng Y. Oncogenic Ras activation in permissive somatic cells triggers rapid onset phenotypic plasticity and elicits a tumour-promoting neutrophil response. bioRxiv [preprint] 2023.11.10.566547; doi: https://doi.org/10.1101/2023.11.10.566547.

Effectiveness of add-on acetazolamide in children with drug-resistant CHD2-related epilepsy and in a zebrafish CHD2 model

Authors:
Melikishvili G, Striano P, Shojeinia E, Gachechiladze T, Kurua E, Tabatadze N, Melikishvili M, Koniashvili O, Khachiashvili G, Epitashvili N, Rimma G, Belyaev O, Tomenko T, Kharytonov V, Guliyeva U, Esguerra CV, Crawford AD, Dulac O
Citation:
Epilepsia Open. 2024 Aug 24. doi: 10.1002/epi4.13034. Epub ahead of print. PMID: 39180515
Epub:
Not Epub
Abstract:
CHD2-related epilepsy is characterized by early-onset photosensitive myoclonic epilepsy with developmental delay and a high...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/epi4.13034
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Melikishvili G, Striano P, Shojeinia E, Gachechiladze T, Kurua E, Tabatadze N, Melikishvili M, Koniashvili O, Khachiashvili G, Epitashvili N, Rimma G, Belyaev O, Tomenko T, Kharytonov V, Guliyeva U, Esguerra CV, Crawford AD, Dulac O. Effectiveness of add-on acetazolamide in children with drug-resistant CHD2-related epilepsy and in a zebrafish CHD2 model. Epilepsia Open. 2024 Aug 24. doi: 10.1002/epi4.13034. Epub ahead of print. PMID: 39180515.

Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis

Authors:
Caetano da Silva C, Macias Trevino C, Mitchell J, Murali H, Tsimbal C, Dalessandro E, Carroll SH, Kochhar S, Curtis SW, Cheng CHE, Wang F, Kutschera E, Carstens RP, Xing Y, Wang K, Leslie EJ, Liao EC
Citation:
Commun Biol. 2024 Aug 23;7(1):1040. doi: 10.1038/s42003-024-06715-3. PMID: 39179789; PMCID: PMC11344038
Epub:
Not Epub
Abstract:
Orofacial cleft (OFC) is a common human congenital anomaly. Epithelial-specific RNA splicing regulators ESRP1 and ESRP2...
Link:
https://www.nature.com/articles/s42003-024-06715-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Caetano da Silva C, Macias Trevino C, Mitchell J, Murali H, Tsimbal C, Dalessandro E, Carroll SH, Kochhar S, Curtis SW, Cheng CHE, Wang F, Kutschera E, Carstens RP, Xing Y, Wang K, Leslie EJ, Liao EC. Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis. Commun Biol. 2024 Aug 23;7(1):1040. doi: 10.1038/s42003-024-06715-3. PMID: 39179789; PMCID: PMC11344038.

mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish

Authors:
Huang W, Yue Y, Hao W, Zhang Z, Cai P, Yang D
Citation:
Stem Cell Reports. Published online August 19, 2024. doi:10.1016/j.stemcr.2024.07.011
Epub:
Not Epub
Abstract:
Mammalian target of rapamycin (mTOR) serves as the key sensor to control protein synthesis, cell growth, and survival. Despite...
Link:
https://www.sciencedirect.com/science/article/pii/S2213671124002200
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Huang W, Yue Y, Hao W, Zhang Z, Cai P, Yang D. mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish. Stem Cell Reports. Published online August 19, 2024. doi:10.1016/j.stemcr.2024.07.011.

Protocadherin 19 regulates axon guidance in the developing Xenopus retinotectal pathway

Authors:
Jung J, Park J, Park S, Kim CH, Jung H
Citation:
Mol Brain. 2024 Aug 22;17(1):58. doi: 10.1186/s13041-024-01130-5. PMID: 39175067
Epub:
Not Epub
Abstract:
Protocadherin 19 (Pcdh19) is a homophilic cell adhesion molecule and is involved in a variety of neuronal functions. Here, we...
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11342623/
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Jung J, Park J, Park S, Kim CH, Jung H. Protocadherin 19 regulates axon guidance in the developing Xenopus retinotectal pathway. Mol Brain. 2024 Aug 22;17(1):58. doi: 10.1186/s13041-024-01130-5. PMID: 39175067 .

Characterization of aberrant splicing in pediatric central nervous system tumors reveals CLK1 as a candidate oncogenic dependency

Authors:
Naqvi AS, Corbett RJ, Seghal P, Conkrite KL, Rathi KS, Ennis BM, Hayer KE, Zhang B, Brown MA, Miller DP, Kraya A, Dybas JM, Geng Z, Blackden C, Arif S, Chroni A, Lahiri A, Hollawell ML, Storm PB, Foster JB, Koptyra M, Madsen PJ, Diskin SJ, Thomas-Tikhonenko A, Resnick AC, Rokita JL
Citation:
bioRxiv [Preprint]. 2024 Aug 22:2024.08.03.606419. doi: 10.1101/2024.08.03.606419. PMID: 39149264
Epub:
Not Epub
Abstract:
Pediatric brain cancer is the leading cause of disease-related mortality in children, and many aggressive tumors still lack...
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11326178/
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: KNS-42
Citation Extract:
Naqvi AS, Corbett RJ, Seghal P, Conkrite KL, Rathi KS, Ennis BM, Hayer KE, Zhang B, Brown MA, Miller DP, Kraya A, Dybas JM, Geng Z, Blackden C, Arif S, Chroni A, Lahiri A, Hollawell ML, Storm PB, Foster JB, Koptyra M, Madsen PJ, Diskin SJ, Thomas-Tikhonenko A, Resnick AC, Rokita JL. Characterization of aberrant splicing in pediatric central nervous system tumors reveals CLK1 as a candidate oncogenic dependency. bioRxiv [Preprint]. 2024 Aug 22:2024.08.03.606419. doi: 10.1101/2024.08.03.606419. PMID: 39149264 .

Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation

Authors:
Lusk S, LaPotin S, Presnell JS, Kwan KM
Citation:
Dev Dyn. 2024 Aug 21. doi: 10.1002/dvdy.733. Online ahead of print. PMID: 39166841
Epub:
Not Epub
Abstract:
Background Uveal coloboma, a developmental eye defect, is caused by failed development of the optic fissure, a ventral...
Link:
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.733
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lusk S, LaPotin S, Presnell JS, Kwan KM. Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation. Dev Dyn. 2024 Aug 21. doi: 10.1002/dvdy.733. Online ahead of print. PMID: 39166841.

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