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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12198 scientific papers returned from the database with the search filters currently being used below.
There are 12198 scientific papers returned from the database with the search filters currently being used below.
5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming
Citation:
Cell. 2024 Aug 28:S0092-8674(24)00902-4. doi: 10.1016/j.cell.2024.08.011. Epub ahead of print. PMID: 39214079 Epub:
Not Epub Abstract:
5-Methylcytosine (5mC) is an established epigenetic mark in vertebrate genomic DNA, but whether its oxidation intermediates... Delivery Method:
microinjection Organism or Cell Type:
Xenopus Citation Extract: Parasyraki E, Mallick M, Hatch V, Vastolo V, Musheev MU, Karaulanov E, Gopanenko A, Moxon S, Méndez-Lago M, Han D, Schomacher L, Mukherjee D, Niehrs C. 5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming. Cell. 2024 Aug 28:S0092-8674(24)00902-4. doi: 10.1016/j.cell.2024.08.011. Epub ahead of print. PMID: 39214079. |
Sequencing of Phosphorodiamidate Morpholino Oligomers by Hydrophilic Interaction Chromatography Coupled to Tandem Mass Spectrometry
Citation:
J Am Soc Mass Spectrom. 2024 Oct 2;35(10):2490-2498. doi: 10.1021/jasms.4c00281. Epub 2024 Aug 30. PMID: 39213635 Epub:
Not Epub Abstract:
Sequencing of phosphorodiamidate morpholino oligomers (PMOs) by hydrophilic interaction chromatography (HILIC) coupled to... Citation Extract: Wang M, O'Day B, Michaels B, Jurayj J, Cai BZ, Wei T. Sequencing of Phosphorodiamidate Morpholino Oligomers by Hydrophilic Interaction Chromatography Coupled to Tandem Mass Spectrometry. J Am Soc Mass Spectrom. 2024 Oct 2;35(10):2490-2498. doi: 10.1021/jasms.4c00281. Epub 2024 Aug 30. PMID: 39213635. |
Structure-Activity Relationship of Antibody-Oligonucleotide Conjugates: Evaluating Bioconjugation Strategies for Antibody-Phosphorodiamidate Morpholino Oligomer Conjugates for Drug Development
Citation:
J Med Chem. 2024 Aug 28. doi: 10.1021/acs.jmedchem.4c00803. Online ahead of print. PMID: 39197837 Epub:
Not Epub Abstract:
Antibody–oligonucleotide conjugates (AOCs) are promising treatments for Duchenne muscular dystrophy (DMD). They work via... Delivery Method:
antibody-linked; intravenous (i.v.) Organism or Cell Type:
mice: ICR, C57BL/6, C57BL/10ScSn-Dmdmdx/J, C57BL/10ScSnJ Citation Extract: Cochran M, Marks I, Albin T, Arias D, Kovach P, Darimont B, Huang H, Etxaniz U, Kwon HW, Shi Y, Diaz M, Tyaglo O, Levin A, Doppalapudi VR. Structure-Activity Relationship of Antibody-Oligonucleotide Conjugates: Evaluating Bioconjugation Strategies for Antibody-Phosphorodiamidate Morpholino Oligomer Conjugates for Drug Development. J Med Chem. 2024 Aug 28. doi: 10.1021/acs.jmedchem.4c00803. Online ahead of print. PMID: 39197837. |
Oncogenic Ras activation in permissive somatic cells triggers rapid onset phenotypic plasticity and elicits a tumour-promoting neutrophil response
Citation:
bioRxiv [preprint] 2023.11.10.566547; doi: https://doi.org/10.1101/2023.11.10.566547 Epub:
Not Epub Abstract:
Oncogenic driver mutations are frequently found in normal tissues, suggesting that additional non-genetic factors are required... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Elliot AM, Ribeiro Bravo I, Astorga Johansson J, Hutton E, Cunningham R, Myllymaki H, Chang KY, Cholewa-Waclaw J, Zhao Y, Dobie R, Beltran M, Lewis A, Elks P, Hansen CG, Henderson N, Feng Y. Oncogenic Ras activation in permissive somatic cells triggers rapid onset phenotypic plasticity and elicits a tumour-promoting neutrophil response. bioRxiv [preprint] 2023.11.10.566547; doi: https://doi.org/10.1101/2023.11.10.566547. |
Effectiveness of add-on acetazolamide in children with drug-resistant CHD2-related epilepsy and in a zebrafish CHD2 model
Citation:
Epilepsia Open. 2024 Aug 24. doi: 10.1002/epi4.13034. Epub ahead of print. PMID: 39180515 Epub:
Not Epub Abstract:
CHD2-related epilepsy is characterized by early-onset photosensitive myoclonic epilepsy with developmental delay and a high... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Melikishvili G, Striano P, Shojeinia E, Gachechiladze T, Kurua E, Tabatadze N, Melikishvili M, Koniashvili O, Khachiashvili G, Epitashvili N, Rimma G, Belyaev O, Tomenko T, Kharytonov V, Guliyeva U, Esguerra CV, Crawford AD, Dulac O. Effectiveness of add-on acetazolamide in children with drug-resistant CHD2-related epilepsy and in a zebrafish CHD2 model. Epilepsia Open. 2024 Aug 24. doi: 10.1002/epi4.13034. Epub ahead of print. PMID: 39180515. |
Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis
Citation:
Commun Biol. 2024 Aug 23;7(1):1040. doi: 10.1038/s42003-024-06715-3. PMID: 39179789; PMCID: PMC11344038 Epub:
Not Epub Abstract:
Orofacial cleft (OFC) is a common human congenital anomaly. Epithelial-specific RNA splicing regulators ESRP1 and ESRP2... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Caetano da Silva C, Macias Trevino C, Mitchell J, Murali H, Tsimbal C, Dalessandro E, Carroll SH, Kochhar S, Curtis SW, Cheng CHE, Wang F, Kutschera E, Carstens RP, Xing Y, Wang K, Leslie EJ, Liao EC. Functional analysis of ESRP1/2 gene variants and CTNND1 isoforms in orofacial cleft pathogenesis. Commun Biol. 2024 Aug 23;7(1):1040. doi: 10.1038/s42003-024-06715-3. PMID: 39179789; PMCID: PMC11344038. |
mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish
Citation:
Stem Cell Reports. Published online August 19, 2024. doi:10.1016/j.stemcr.2024.07.011 Epub:
Not Epub Abstract:
Mammalian target of rapamycin (mTOR) serves as the key sensor to control protein synthesis, cell growth, and survival. Despite... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Huang W, Yue Y, Hao W, Zhang Z, Cai P, Yang D. mTORC1 mediates the expansion of hematopoietic stem and progenitor cells through ribosome biogenesis protein Urb2 in zebrafish. Stem Cell Reports. Published online August 19, 2024. doi:10.1016/j.stemcr.2024.07.011. |
Protocadherin 19 regulates axon guidance in the developing Xenopus retinotectal pathway
Citation:
Mol Brain. 2024 Aug 22;17(1):58. doi: 10.1186/s13041-024-01130-5. PMID: 39175067 Epub:
Not Epub Abstract:
Protocadherin 19 (Pcdh19) is a homophilic cell adhesion molecule and is involved in a variety of neuronal functions. Here, we... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Jung J, Park J, Park S, Kim CH, Jung H. Protocadherin 19 regulates axon guidance in the developing Xenopus retinotectal pathway. Mol Brain. 2024 Aug 22;17(1):58. doi: 10.1186/s13041-024-01130-5. PMID: 39175067 . |
Characterization of aberrant splicing in pediatric central nervous system tumors reveals CLK1 as a candidate oncogenic dependency
Citation:
bioRxiv [Preprint]. 2024 Aug 22:2024.08.03.606419. doi: 10.1101/2024.08.03.606419. PMID: 39149264 Epub:
Not Epub Abstract:
Pediatric brain cancer is the leading cause of disease-related mortality in children, and many aggressive tumors still lack... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
cell culture: KNS-42 Citation Extract: Naqvi AS, Corbett RJ, Seghal P, Conkrite KL, Rathi KS, Ennis BM, Hayer KE, Zhang B, Brown MA, Miller DP, Kraya A, Dybas JM, Geng Z, Blackden C, Arif S, Chroni A, Lahiri A, Hollawell ML, Storm PB, Foster JB, Koptyra M, Madsen PJ, Diskin SJ, Thomas-Tikhonenko A, Resnick AC, Rokita JL. Characterization of aberrant splicing in pediatric central nervous system tumors reveals CLK1 as a candidate oncogenic dependency. bioRxiv [Preprint]. 2024 Aug 22:2024.08.03.606419. doi: 10.1101/2024.08.03.606419. PMID: 39149264 . |
Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation
Citation:
Dev Dyn. 2024 Aug 21. doi: 10.1002/dvdy.733. Online ahead of print. PMID: 39166841 Epub:
Not Epub Abstract:
Background
Uveal coloboma, a developmental eye defect, is caused by failed development of the optic fissure, a ventral... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lusk S, LaPotin S, Presnell JS, Kwan KM. Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation. Dev Dyn. 2024 Aug 21. doi: 10.1002/dvdy.733. Online ahead of print. PMID: 39166841. |