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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
There are 12138 scientific papers returned from the database with the search filters currently being used below.
Hematopoietic stem cell division is governed by distinct RUNX1 binding partners
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Citation:
bioRxiv [Preprint]. 2024 Jun 8:2024.06.07.596542. doi: 10.1101/2024.06.07.596542. PMID: 38895208; PMCID: PMC11185638 Epub:
Not Epub Abstract:
A defined number of hematopoietic stem cell (HSC) clones are born during development and expand to form the pool of adult stem... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Robertson AL, Yue L, Choudhuri A, Kubaczka C, Wattrus SJ, Mandelbaum J, Avagyan S, Yang S, Freeman RJ, Chan V, Blair MC, Daley GQ, Zon LI. Hematopoietic stem cell division is governed by distinct RUNX1 binding partners. bioRxiv [Preprint]. 2024 Jun 8:2024.06.07.596542. doi: 10.1101/2024.06.07.596542. PMID: 38895208; PMCID: PMC11185638. |
Fine-Tuning Amyloid Precursor Protein Expression through Nonsense-Mediated mRNA Decay
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Citation:
eNeuro. 2024 Jun 10;11(6):ENEURO.0034-24.2024. doi: 10.1523/ENEURO.0034-24.2024. PMID: 38789273; PMCID: PMC11164851 Epub:
Not Epub Abstract:
Studies on genetic robustness recently revealed transcriptional adaptation (TA) as a mechanism by which an organism can... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Rahmati M, Chebli J, Kumar Banote R, Roselli S, Agholme L, Zetterberg H, Abramsson A. Fine-Tuning Amyloid Precursor Protein Expression through Nonsense-Mediated mRNA Decay. eNeuro. 2024 Jun 10;11(6):ENEURO.0034-24.2024. doi: 10.1523/ENEURO.0034-24.2024. PMID: 38789273; PMCID: PMC11164851. |
Sex-dependent regulation of vertebrate somatic growth and aging by germ cells
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Citation:
Sci Adv. 2024 Jun 14;10(24):eadi1621. doi: 10.1126/sciadv.adi1621. Epub 2024 Jun 12. PMID: 38865462; PMCID: PMC11168456. Epub:
Not Epub Abstract:
The function of germ cells in somatic growth and aging has been demonstrated in invertebrate models but remains unclear in... Delivery Method:
microinjection Organism or Cell Type:
Nothobranchius furzeri Citation Extract: Abe K, Ino H, Niwa T, Semmy D, Takaochi A, Nishimura T, Mogi C, Uenaka M, Ishii M, Tanaka K, Ohkawa Y, Ishitani T. Sex-dependent regulation of vertebrate somatic growth and aging by germ cells. Sci Adv. 2024 Jun 14;10(24):eadi1621. doi: 10.1126/sciadv.adi1621. Epub 2024 Jun 12. PMID: 38865462; PMCID: PMC11168456.. |
Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility
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Citation:
bioRxiv [preprint] 2024.05.28.593642; doi: https://doi.org/10.1101/2024.05.28.593642 Epub:
Not Epub Abstract:
The comorbidity of autism spectrum disorders and severe gastrointestinal symptoms is well-established, yet the molecular... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: McCluskey KE, Stovell KM, Law K, Kostyanovskaya E, Schmidt J, Exner CRT, Dea J, Brimble E, State MW, Willsey J, Willsey HR. Autism gene variants disrupt enteric neuron migration and cause gastrointestinal dysmotility. bioRxiv [preprint] 2024.05.28.593642; doi: https://doi.org/10.1101/2024.05.28.593642. |
Tumor pretargeting in mice using MORF conjugated CC49 antibody and radiolabeled complimentary cMORF effector
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Citation:
Q J Nucl Med Mol Imaging. 2010 Jun;54(3):333-40. Epub 2009 Dec 15. PMID: 20639818; PMCID: PMC2939249 Epub:
Not Epub Abstract:
We previously reported high CD46 expression in prostate cancer and developed an antibody-drug conjugate and immunoPET agent... Delivery Method:
antibody-conjugate; in vivo: intravenous Organism or Cell Type:
LS174T cells; Swiss NIH nude mice explant Citation Extract: Liu G, Dou S, Pretorius PH, Liu X, Chen L, Rusckowski M, Hnatowich DJ. Tumor pretargeting in mice using MORF conjugated CC49 antibody and radiolabeled complimentary cMORF effector. Q J Nucl Med Mol Imaging. 2010 Jun;54(3):333-40. Epub 2009 Dec 15. PMID: 20639818; PMCID: PMC2939249. |
Nkd1 functions downstream of Axin2 to attenuate Wnt signaling
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Citation:
Mol Biol Cell. 2024 Jul 1;35(7):ar93. doi: 10.1091/mbc.E24-02-0059-T. Epub 2024 Apr 24. PMID: 38656801 Epub:
Not Epub Abstract:
Wnt signaling is a crucial developmental pathway involved in early development as well as stem-cell maintenance in adults and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Bell I, Khan H, Stutt N, Horn M, Hydzik T, Lum W, Rea V, Clapham E, Hoeg L, Van Raay TJ. Nkd1 functions downstream of Axin2 to attenuate Wnt signaling. Mol Biol Cell. 2024 Jul 1;35(7):ar93. doi: 10.1091/mbc.E24-02-0059-T. Epub 2024 Apr 24. PMID: 38656801. |
Comparing cell penetration of biotherapeutics across human cell lines
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Citation:
bioRxiv [preprint] 2024.03.28.587257; doi: https://doi.org/10.1101/2024.03.28.587257 Epub:
Not Epub Abstract:
A major obstacle in biotherapeutics development is maximizing cell penetration. Ideally, assays would allow for optimization of... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: Hela, Saos-2, U2OS,MIA PcCa-2 HEK293-T, BxPC-3, HepG2 Citation Extract: Batistatou N and Kritzer J. Comparing cell penetration of biotherapeutics across human cell lines. bioRxiv [preprint] 2024.03.28.587257; doi: https://doi.org/10.1101/2024.03.28.587257. |
Targeted Antisense Oligonucleotide-Mediated Skipping of Murine Postn Exon 17 Partially Addresses Fibrosis in D2.mdx Mice
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Citation:
International Journal of Molecular Sciences. 2024; 25(11):6113. https://doi.org/10.3390/ijms25116113 Epub:
Not Epub Abstract:
Periostin, a multifunctional 90 kDa protein, plays a pivotal role in the pathogenesis of fibrosis across various tissues,... Delivery Method:
intraperitoneal Vivo-Morpholino in vivo, Endo-Porter in culture Organism or Cell Type:
mouse skeletal muscle fibroblast cells; D2-mdx and Dba-2J mice Citation Extract: Trundle J, Lu-Nguyen N, Malerba A, Popplewell L. Targeted Antisense Oligonucleotide-Mediated Skipping of Murine Postn Exon 17 Partially Addresses Fibrosis in D2.mdx Mice. International Journal of Molecular Sciences. 2024; 25(11):6113. https://doi.org/10.3390/ijms25116113. |
Genetic Inactivation of the β1 adrenergic receptor prevents Cerebral Cavernous Malformations in zebrafish preprint
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Citation:
bioRxiv 2024.05.05.592554; doi.org/10.1101/2024.05.05.592554 Epub:
Not Epub Abstract:
Propranolol reduces experimental murine cerebral cavernous malformations (CCMs) and prevents embryonic caudal venous plexus (... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Li W, McCurdy S, Lopez-Ramirez MA, Lee HS. Genetic Inactivation of the β1 adrenergic receptor prevents Cerebral Cavernous Malformations in zebrafish preprint. bioRxiv 2024.05.05.592554; doi.org/10.1101/2024.05.05.592554. |
Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide
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Citation:
Biomed Pharmacother. 2024 Jun;175:116737. doi: 10.1016/j.biopha.2024.116737. Epub 2024 May 14. PMID: 38749176 Epub:
Not Epub Abstract:
Antisense oligonucleotide (ASO) has emerged as a promising therapeutic approach for treating central nervous system (CNS)... Delivery Method:
BBB-penetrating peptide-linked Organism or Cell Type:
SMA Type-I patient-derived fibroblasts, SMN2 transgenic mice Citation Extract: Yeoh YQ, Amin A, Cuic B, Tomas D, Turner BJ, Shabanpoor F. Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with a blood-brain barrier-penetrating ApoE-derived peptide. Biomed Pharmacother. 2024 Jun;175:116737. doi: 10.1016/j.biopha.2024.116737. Epub 2024 May 14. PMID: 38749176. |