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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12338 scientific papers returned from the database with the search filters currently being used below.

Double assurance in the induction of axial development by egg dorsal determinants in Xenopus embryos

Authors:
Azbazdar Y, De Robertis EM
Citation:
Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2421772122. doi: 10.1073/pnas.2421772122. Epub 2025 Feb 10. PMID: 39928870; PMCID: PMC11848351
Epub:
Not Epub
Abstract:
We recently reported that microinjection of Xenopus nodal-related (xnr) mRNAs into β-catenin-depleted Xenopus embryos rescued a...
Link:
https://www.pnas.org/doi/10.1073/pnas.2421772122
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Azbazdar Y, De Robertis EM. Double assurance in the induction of axial development by egg dorsal determinants in Xenopus embryos. Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2421772122. doi: 10.1073/pnas.2421772122. Epub 2025 Feb 10. PMID: 39928870; PMCID: PMC11848351.

Alternative splicing of CADM1 is associated with endothelial progenitor cell dysfunction in preeclampsia

Authors:
Welz R, Ramachandran D, Schröder-Heurich B, Richter K, Geffers R, von Kaisenberg CS, Dörk T, von Versen-Höynck F
Citation:
Physiol Genomics. 2025 Feb 10. doi: 10.1152/physiolgenomics.00006.2024. Epub ahead of print. PMID: 39928918
Epub:
Not Epub
Abstract:
Preeclampsia is a pregnancy specific hypertensive disorder and is associated with an increased postpartum risk of...
Link:
https://journals.physiology.org/doi/abs/10.1152/physiolgenomics.00006.2024
Delivery Method:
Lipofectamine 3000
Organism or Cell Type:
cell culture: cord blood endothelial colony forming cells (ECFCs)
Citation Extract:
Welz R, Ramachandran D, Schröder-Heurich B, Richter K, Geffers R, von Kaisenberg CS, Dörk T, von Versen-Höynck F. Alternative splicing of CADM1 is associated with endothelial progenitor cell dysfunction in preeclampsia. Physiol Genomics. 2025 Feb 10. doi: 10.1152/physiolgenomics.00006.2024. Epub ahead of print. PMID: 39928918.

CMTM4 is an adhesion modulator that regulates skeletal patterning and primary mesenchyme cell migration in sea urchin embryos

Authors:
Descoteaux AE, Radulovic M, Alburi D, Bradham CA
Citation:
Dev Biol. 2025 Feb 11;521:85-95. doi: 10.1016/j.ydbio.2025.02.009. Epub ahead of print. PMID: 39947420
Epub:
Not Epub
Abstract:
MARVEL proteins, including those of the CMTM gene family, are multi-pass transmembrane proteins that play important roles in...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160625000454
Delivery Method:
microinjection
Organism or Cell Type:
Lytechinus variegatus (sea urchin)
Citation Extract:
Descoteaux AE, Radulovic M, Alburi D, Bradham CA. CMTM4 is an adhesion modulator that regulates skeletal patterning and primary mesenchyme cell migration in sea urchin embryos. Dev Biol. 2025 Feb 11;521:85-95. doi: 10.1016/j.ydbio.2025.02.009. Epub ahead of print. PMID: 39947420.

CRISPR-Cas13d as a molecular tool to achieve targeted gene expression knockdown in chick embryos

Authors:
Kim M, Hutchins EJ
Citation:
Dev Biol. 2025 Mar;519:5-12. doi: 10.1016/j.ydbio.2024.11.013. Epub 2024 Nov 30. PMID: 39622311; PMCID: PMC11824683
Epub:
Not Epub
Abstract:
The chick embryo is a classical model system commonly used in developmental biology due to its amenability to gene perturbation...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160624002653
Delivery Method:
electroporation
Organism or Cell Type:
chick embryo
Citation Extract:
Kim M, Hutchins EJ. CRISPR-Cas13d as a molecular tool to achieve targeted gene expression knockdown in chick embryos. Dev Biol. 2025 Mar;519:5-12. doi: 10.1016/j.ydbio.2024.11.013. Epub 2024 Nov 30. PMID: 39622311; PMCID: PMC11824683.

A peptide conjugate enables systemic injection of the morpholino inducer and more durable induction of T3H38 ribozyme-controlled AAV transgene in mice

Authors:
Tang X, Wang H, Yin Y, Zhong G
Citation:
Gene Ther. 2025 Feb 12. doi: 10.1038/s41434-025-00519-8. Epub ahead of print. PMID: 39939797
Epub:
Not Epub
Abstract:
Genetic switches that allow for precise control over transgene expression timing or levels may improve the safety and expand...
Link:
https://www.nature.com/articles/s41434-025-00519-8
Delivery Method:
peptide-linked, Vivo-Morpholino
Organism or Cell Type:
mouse
Citation Extract:
Tang X, Wang H, Yin Y, Zhong G. A peptide conjugate enables systemic injection of the morpholino inducer and more durable induction of T3H38 ribozyme-controlled AAV transgene in mice. Gene Ther. 2025 Feb 12. doi: 10.1038/s41434-025-00519-8. Epub ahead of print. PMID: 39939797.

A Population Pharmacokinetic Model to Inform Extension of the Eteplirsen Dosing Regimen Across the Broad DMD Population

Authors:
Patel Y, Orogun L, Yocum N, Rodino-Klapac LR, East L
Citation:
CPT Pharmacometrics Syst Pharmacol. 2025 Feb 26. doi: 10.1002/psp4.70001. Epub ahead of print. PMID: 40009522
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is characterized by progressive, irreversible muscle damage that usually leads to premature...
Link:
https://ascpt.onlinelibrary.wiley.com/doi/10.1002/psp4.70001
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Patel Y, Orogun L, Yocum N, Rodino-Klapac LR, East L. A Population Pharmacokinetic Model to Inform Extension of the Eteplirsen Dosing Regimen Across the Broad DMD Population. CPT Pharmacometrics Syst Pharmacol. 2025 Feb 26. doi: 10.1002/psp4.70001. Epub ahead of print. PMID: 40009522.

Improved induction of ribozyme-controlled AAV transgene via peptide-conjugated morpholino oligos

Authors:
Cheng T, Chen B, Zou W
Citation:
Gene Ther. 2025 Feb 26. doi: 10.1038/s41434-025-00520-1. Epub ahead of print. PMID: 40011707
Epub:
Not Epub
Abstract:
Genetic switches that allow for precise control over transgene expression timing or levels may improve the safety and expand...
Link:
https://www.nature.com/articles/s41434-025-00520-1
Delivery Method:
peptide-linked
Organism or Cell Type:
mouse
Citation Extract:
Cheng T, Chen B, Zou W. Improved induction of ribozyme-controlled AAV transgene via peptide-conjugated morpholino oligos. Gene Ther. 2025 Feb 26. doi: 10.1038/s41434-025-00520-1. Epub ahead of print. PMID: 40011707.

Unveiling the role of RPS17 and SLC4A1 in diamond-Blackfan Anemia: A zebrafish-based study

Authors:
Kim K, Lee H, Ahn S, Kim YH, Oh CK
Citation:
Blood Cells Mol Dis. 2025 Feb 25;112:102912. doi: 10.1016/j.bcmd.2025.102912. Epub ahead of print. PMID: 40015014
Epub:
Not Epub
Abstract:
Diamond-Blackfan Anemia (DBA) is a rare congenital disorder characterized by macrocytic anemia, physical abnormalities, and...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S107997962500004X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kim K, Lee H, Ahn S, Kim YH, Oh CK . Unveiling the role of RPS17 and SLC4A1 in diamond-Blackfan Anemia: A zebrafish-based study. Blood Cells Mol Dis. 2025 Feb 25;112:102912. doi: 10.1016/j.bcmd.2025.102912. Epub ahead of print. PMID: 40015014.

TGF-β signaling controls neural crest developmental plasticity via SMAD2/3

Authors:
Rothstein M, Azambuja AP, Kanno TY, Breen C, Simoes-Costa M
Citation:
Dev Cell. 2025 Feb 18:S1534-5807(25)00059-0. doi: 10.1016/j.devcel.2025.01.018. Epub ahead of print. PMID: 39983721
Epub:
Not Epub
Abstract:
The neural crest is a highly plastic stem cell population that represents an exception to the germ layer theory. Despite being...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S1534580725000590
Delivery Method:
electroporation
Organism or Cell Type:
chick embryo
Citation Extract:
Rothstein M, Azambuja AP, Kanno TY, Breen C, Simoes-Costa M. TGF-β signaling controls neural crest developmental plasticity via SMAD2/3. Dev Cell. 2025 Feb 18:S1534-5807(25)00059-0. doi: 10.1016/j.devcel.2025.01.018. Epub ahead of print. PMID: 39983721.

Dominant rhabdomyolysis linked to a recurrent ATP2A2 variant reducing SERCA2 function in muscle

Authors:
Malaichamy S, Idoux R, Polavarapu K, Šikić K, Holla E, Thompson R, Spendiff S, Schänzer A, Kusters B, Freeman E, Hentschel A, O'Neil D, Carmona-Martinez R, Dobelmann V, Tucht C, Schouten M, Ruck T, Schara-Schmidt U, Kamsteeg EJ, Ramadža DP, Jakovčević A, Zigman T, Čavka M, Karcagi V, Herczegfalvi A, Laurie S, Matalonga L, Beltran S, Horvath R, Voermans N, Roos A, Barić I, Lochmüller H
Citation:
Brain. 2025 Feb 19:awaf067. doi: 10.1093/brain/awaf067. Epub ahead of print. PMID: 39970126
Epub:
Not Epub
Abstract:
Rhabdomyolysis is an acute failure of cellular homeostasis resulting in muscle breakdown, triggered by trauma, infection, drugs...
Link:
https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awaf067/8024349
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Malaichamy S, Idoux R, Polavarapu K, Šikić K, Holla E, Thompson R, Spendiff S, Schänzer A, Kusters B, Freeman E, Hentschel A, O'Neil D, Carmona-Martinez R, Dobelmann V, Tucht C, Schouten M, Ruck T, Schara-Schmidt U, Kamsteeg EJ, Ramadža DP, Jakovčević A, Zigman T, Čavka M, Karcagi V, Herczegfalvi A, Laurie S, Matalonga L, Beltran S, Horvath R, Voermans N, Roos A, Barić I, Lochmüller H. Dominant rhabdomyolysis linked to a recurrent ATP2A2 variant reducing SERCA2 function in muscle. Brain. 2025 Feb 19:awaf067. doi: 10.1093/brain/awaf067. Epub ahead of print. PMID: 39970126.

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