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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12255 scientific papers returned from the database with the search filters currently being used below.
There are 12255 scientific papers returned from the database with the search filters currently being used below.
Proliferation associated 2G4 is required for the ciliation of vertebrate motile cilia
Citation:
Commun Biol. 2024 Nov 4;7(1):1430. doi: 10.1038/s42003-024-07150-0. PMID: 39496919; PMCID: PMC11535434 Epub:
Not Epub Abstract:
Motile cilia are critical structures that regulate early embryonic development and tissue homeostasis through synchronized... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Lee M, Carpenter C, Hwang YS, Yoon J, Lu Q, Westlake CJ, Moody SA, Yamaguchi TP, Daar IO. Proliferation associated 2G4 is required for the ciliation of vertebrate motile cilia. Commun Biol. 2024 Nov 4;7(1):1430. doi: 10.1038/s42003-024-07150-0. PMID: 39496919; PMCID: PMC11535434. |
The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation. Cytoskeleton (Hoboken)
Citation:
2024 Oct 31. doi: 10.1002/cm.21952. Epub ahead of print. PMID: 39479942 Epub:
Not Epub Abstract:
Mutations in CCDC11 (cfap53) have been identified in multiple patients with heterotaxy (Htx), a disorder of left–right (LR)... Delivery Method:
microinjection Organism or Cell Type:
Xenopus tropicalis Citation Extract: Kulkarni SS, Stephenson RE, Amalraj S, Arrigo A, Betleja E, Moresco JJ, Yates JR 3rd, Mahjoub MR, Miller AL, Khokha MK . The Heterotaxy Gene CCDC11 Is Important for Cytokinesis via RhoA Regulation. Cytoskeleton (Hoboken). 2024 Oct 31. doi: 10.1002/cm.21952. Epub ahead of print. PMID: 39479942. |
Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments
Citation:
PLoS Biol. 2024 Nov 11;22(11):e3002895. doi: 10.1371/journal.pbio.3002895. Epub ahead of print. PMID: 39527653 Epub:
Not Epub Abstract:
Mitochondria regulate several physiological functions through mitochondrial Ca2+ dynamics. However, role of mitochondrial Ca2+... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Tanwar J, Ahuja K, Sharma A, Sehgal P, Ranjan G, Sultan F, Agrawal A, D'Angelo D, Priya A, Yenamandra VK, Singh A, Raffaello A, Madesh M, Rizzuto R, Sivasubbu S, Motiani RK. Mitochondrial calcium uptake orchestrates vertebrate pigmentation via transcriptional regulation of keratin filaments. PLoS Biol. 2024 Nov 11;22(11):e3002895. doi: 10.1371/journal.pbio.3002895. Epub ahead of print. PMID: 39527653. |
Manic Fringe promotes endothelial-to-mesenchymal transition mediated by the Notch signalling pathway during heart valve development
Citation:
J Mol Med (Berl). 2024 Nov 11. doi: 10.1007/s00109-024-02492-y. Epub ahead of print. PMID: 39528804 Epub:
Not Epub Abstract:
A fundamental event in the formation of heart valves involves the transformation of endocardial cells within the outflow... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yang J, Wang Z, Zhou Y, Jiang S, Qin X, Xu Z, Wang Y, Zuo M, Meng Z, Chen S, Wang Q, Wang J, Sun K. Manic Fringe promotes endothelial-to-mesenchymal transition mediated by the Notch signalling pathway during heart valve development. J Mol Med (Berl). 2024 Nov 11. doi: 10.1007/s00109-024-02492-y. Epub ahead of print. PMID: 39528804. |
Characterization of Nonclinical Drug Metabolism and Pharmacokinetic Properties of Phosphorodiamidate Morpholino Oligonucleotides, A Novel Drug Class for Duchenne Muscular Dystrophy
Citation:
Drug Metab Dispos. 2024 Nov 8:DMD-AR-2024-001819. doi: 10.1124/dmd.124.001819. Epub ahead of print. PMID: 39516029 Epub:
Not Epub Abstract:
Eteplirsen, golodirsen, and casimersen are phosphorodiamidate morpholino oligomers (PMOs) that are approved in the United... Delivery Method:
intravenous (i.v.) bolus Organism or Cell Type:
in vivo: CByB6F1 & mdx mice, Sprague Dawley rats & cynomolgus monkeys; in vitro: hepatic microsomes from CD-1 mice, Sprague Dawley rats, cynomolgus monkeys and humans; cell culture: Caco-2, CHO & HEK293 Citation Extract: Goey A, Mukashyaka MC, Patel Y, Rodino-Klapac LR, East L. Characterization of Nonclinical Drug Metabolism and Pharmacokinetic Properties of Phosphorodiamidate Morpholino Oligonucleotides, A Novel Drug Class for Duchenne Muscular Dystrophy. Drug Metab Dispos. 2024 Nov 8:DMD-AR-2024-001819. doi: 10.1124/dmd.124.001819. Epub ahead of print. PMID: 39516029. |
F86. Molecular mechanism of the TNIK gene affecting the action of antipsychotic drugs through the glutamate pathway
Citation:
European Neuropsychopharmacology, Volume 87, Supplement 1, 2024, Pages 251-252, ISSN 0924-977X, https://doi.org/10.1016/j.euroneuro.2024.08.497 Epub:
Not Epub Abstract:
Background
Schizophrenia (SCZ) is a complex psychiatric disorder primarily treated with antipsychotic drugs (APDs), yet the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Xu Q, Qin S, He L, Yu S. F86. Molecular mechanism of the TNIK gene affecting the action of antipsychotic drugs through the glutamate pathway. European Neuropsychopharmacology, Volume 87, Supplement 1, 2024, Pages 251-252, ISSN 0924-977X, https://doi.org/10.1016/j.euroneuro.2024.08.497. |
Multi-omics integration analysis identifies pathogenic candidate genes of congenital heart defects with vascular malformation
Citation:
European Heart Journal, Volume 45, Issue Supplement_1, October 2024, ehae666.2109, https://doi.org/10.1093/eurheartj/ehae666.2109 Epub:
Not Epub Abstract:
Background
Congenital heart defects (CHD) with vascular malformation harbors numerous genetic and epigenetic aberrations of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ding XW, Huang JX, Chen YH, Li ZY, Wu YZ, Qian ZL, Feng WQ, Li YR, Zhao LD, Zhao PJ, Lu YN, Yu Y. Multi-omics integration analysis identifies pathogenic candidate genes of congenital heart defects with vascular malformation. European Heart Journal, Volume 45, Issue Supplement_1, October 2024, ehae666.2109, https://doi.org/10.1093/eurheartj/ehae666.2109. |
Actin Depolymerizing Factor Destrin Regulates Cilia Development and Function during Vertebrate Embryogenesis
Citation:
Dev Reprod. 2024 Sep;28(3):109-119. doi: 10.12717/DR.2024.28.3.109. Epub 2024 Sep 30. PMID: 39444639; PMCID: PMC11495882 Epub:
Not Epub Abstract:
The actin cytoskeleton plays fundamental roles in ciliogenesis and the actin depolymerizing factor destrin regulates actin... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Kim Y, Lee HK, Park KY, Ismail T, Lee H, Lee HS. Actin Depolymerizing Factor Destrin Regulates Cilia Development and Function during Vertebrate Embryogenesis. Dev Reprod. 2024 Sep;28(3):109-119. doi: 10.12717/DR.2024.28.3.109. Epub 2024 Sep 30. PMID: 39444639; PMCID: PMC11495882. |
Light-modulated neural control of sphincter regulation in the evolution of through-gut
Citation:
Nat Commun. 2024 Oct 18;15(1):8881. doi: 10.1038/s41467-024-53203-7. PMID: 39424783; PMCID: PMC11489725 Epub:
Not Epub Abstract:
The development of a continuous digestive tract, or through-gut, represents a key milestone in bilaterian evolution. However,... Delivery Method:
microinjection Organism or Cell Type:
Hemicentrotus pulcherrimus (sea urchin) Citation Extract: Yaguchi J, Sakai K, Horiuchi A, Yamamoto T, Yamashita T, Yaguchi S. Light-modulated neural control of sphincter regulation in the evolution of through-gut. Nat Commun. 2024 Oct 18;15(1):8881. doi: 10.1038/s41467-024-53203-7. PMID: 39424783; PMCID: PMC11489725. |
Hypusinated and unhypusinated isoforms of eIF5A exert distinct effects in models of pancreas development and function
Citation:
bioRxiv [preprint] 2024.10.27.620489; doi: https://doi.org/10.1101/2024.10.27.620489 Epub:
Not Epub Abstract:
Hypusination of eukaryotic translation initiation factor 5A (eIF5A) is essential for its role in translation elongation and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Anderson CM, Kulkarni A, Maier B, Huang F, Figatner K, Chakraborty A, Pratuangtham S, May SC, Tersey SA, Anderson RM, Mirmira RG. Hypusinated and unhypusinated isoforms of eIF5A exert distinct effects in models of pancreas development and function. bioRxiv [preprint] 2024.10.27.620489; doi: https://doi.org/10.1101/2024.10.27.620489. |