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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11141 scientific papers returned from the database with the search filters currently being used below.

Zebrafish NIK Mediates IFN Induction by Regulating Activation of IRF3 and NF-kappaB

Authors:
Chen B, Li C, Yao J, Shi L, Liu W, Wang F, Huo S, Zhang Y, Lu Y, Ashraf U, Ye J, Liu X
Citation:
J Immunol. 2020 Apr 1;204(7):1881-1891. doi: 10.4049/jimmunol.1900561. Epub 2020 Feb 17
Epub:
Not Epub
Abstract:
Type I IFN mediates the innate immune system to provide defense against viral infections. NF-κB-inducing kinase (NIK)...
Organism or Cell Type:
zebrafish
Citation Extract:
Chen B, Li C, Yao J, Shi L, Liu W, Wang F, Huo S, Zhang Y, Lu Y, Ashraf U, Ye J, Liu X. Zebrafish NIK Mediates IFN Induction by Regulating Activation of IRF3 and NF-kappaB. J Immunol. 2020 Apr 1;204(7):1881-1891. doi: 10.4049/jimmunol.1900561. Epub 2020 Feb 17.

Bifunctional small molecule-oligonucleotide hybrid as microRNA inhibitor

Authors:
Bhattarai U, Hsieh WC, Yan H, Guo ZF, Shaikh AY, Soltani A, Song Y, Ly DH, Liang FS
Citation:
Bioorg Med Chem. 2020 Apr 1;28(7):115394. doi: 10.1016/j.bmc.2020.115394. Epub 2020 Feb 18
Epub:
Not Epub
Abstract:
miRNAs are key regulators of various biological processes. Dysregulation of miRNA is linked to many diseases. Development of...
Citation Extract:
Bhattarai U, Hsieh WC, Yan H, Guo ZF, Shaikh AY, Soltani A, Song Y, Ly DH, Liang FS. Bifunctional small molecule-oligonucleotide hybrid as microRNA inhibitor. Bioorg Med Chem. 2020 Apr 1;28(7):115394. doi: 10.1016/j.bmc.2020.115394. Epub 2020 Feb 18.

A novel TRIM family member, Trim69, regulates zebrafish development through p53-mediated apoptosis

Authors:
Han R, Zhao Q, Zong S, Miao S, Song W, Wang L
Citation:
Mol Reprod Dev. 2016 May;83(5):442-54. doi: 10.1002/mrd.22643. Epub 2016 May 6
Epub:
Not Epub
Abstract:
Trim69 contains the hallmark domains of a tripartite motif (TRIM) protein, including a Ring-finger domain, B-box domain, and...
Organism or Cell Type:
zebrafish
Citation Extract:
Han R, Zhao Q, Zong S, Miao S, Song W, Wang L. A novel TRIM family member, Trim69, regulates zebrafish development through p53-mediated apoptosis. Mol Reprod Dev. 2016 May;83(5):442-54. doi: 10.1002/mrd.22643. Epub 2016 May 6.

De Novo ARID1B mutations cause growth delay associated with aberrant Wnt/beta-catenin signaling

Authors:
Liu X, Hu G, Ye J, Ye B, Shen N, Tao Y, Zhang X, Fan Y, Liu H, Zhang Z, Fang D, Gu X, Mo X, Yu Y
Citation:
Hum Mutat. 2020 May;41(5):1012-1024. doi: 10.1002/humu.23990. Epub 2020 Mar 3
Epub:
Not Epub
Abstract:
Haploinsufficiency of ARID1B (AT-rich interaction domain 1B) has been involved in autism spectrum disorder, nonsyndromic and...
Organism or Cell Type:
zebrafish
Citation Extract:
Liu X, Hu G, Ye J, Ye B, Shen N, Tao Y, Zhang X, Fan Y, Liu H, Zhang Z, Fang D, Gu X, Mo X, Yu Y. De Novo ARID1B mutations cause growth delay associated with aberrant Wnt/beta-catenin signaling. Hum Mutat. 2020 May;41(5):1012-1024. doi: 10.1002/humu.23990. Epub 2020 Mar 3.

TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci

Authors:
Davis EE, Balasubramanian R, Kupchinsky ZA, Keefe DL, Plummer L, Khan K, Meczekalski B, Heath KE, Lopez-Gonzalez V, Ballesta-Martinez MJ, Margabanthu G, Price S, Greening J, Brauner R, Valenzuela I, Cusco I, Fernandez-Alvarez P, Wierman ME, Li T, Lage K, Barroso PS, Chan YM, Crowley WF, Katsanis N
Citation:
Hum Mol Genet. 2020 Aug 11;29(14):2435-2450. doi: 10.1093/hmg/ddaa120
Epub:
Not Epub
Abstract:
Dysfunction of the gonadotropin-releasing hormone (GnRH) axis causes a range of reproductive phenotypes resulting from defects...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Davis EE, Balasubramanian R, Kupchinsky ZA, Keefe DL, Plummer L, Khan K, Meczekalski B, Heath KE, Lopez-Gonzalez V, Ballesta-Martinez MJ, Margabanthu G, Price S, Greening J, Brauner R, Valenzuela I, Cusco I, Fernandez-Alvarez P, Wierman ME, Li T, Lage K, Barroso PS, Chan YM, Crowley WF, Katsanis N. TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci. Hum Mol Genet. 2020 Aug 11;29(14):2435-2450. doi: 10.1093/hmg/ddaa120.

Copper stress induces zebrafish central neural system myelin defects via WNT/NOTCH-hoxb5b signaling and pou3f1/fam168a/fam168b DNA methylation

Authors:
Zhang T, Guan P, Liu W, Zhao G, Fang Y, Fu H, Gui JF, Li G, Liu JX
Citation:
Biochim Biophys Acta Gene Regul Mech. 2020 Oct;1863(10):194612. doi: 10.1016/j.bbagrm.2020.194612
Epub:
Not Epub
Abstract:
Unbalanced copper (Cu) homeostasis is associated with neurological development defects and diseases. However, the molecular...
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang T, Guan P, Liu W, Zhao G, Fang Y, Fu H, Gui JF, Li G, Liu JX. Copper stress induces zebrafish central neural system myelin defects via WNT/NOTCH-hoxb5b signaling and pou3f1/fam168a/fam168b DNA methylation. Biochim Biophys Acta Gene Regul Mech. 2020 Oct;1863(10):194612. doi: 10.1016/j.bbagrm.2020.194612.

Gsx2 is required for specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neural progenitors in zebrafish

Authors:
Itoh T, Takeuchi M, Sakagami M, Asakawa K, Sumiyama K, Kawakami K, Shimizu T, Hibi M
Citation:
Development. 2020 Oct 9;147(19):dev190603. doi: 10.1242/dev.190603
Epub:
Not Epub
Abstract:
Neurons in the inferior olivary nuclei (IO neurons) send climbing fibers to Purkinje cells to elicit functions of the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Itoh T, Takeuchi M, Sakagami M, Asakawa K, Sumiyama K, Kawakami K, Shimizu T, Hibi M. Gsx2 is required for specification of neurons in the inferior olivary nuclei from Ptf1a-expressing neural progenitors in zebrafish. Development. 2020 Oct 9;147(19):dev190603. doi: 10.1242/dev.190603.

Functional contribution of DCLKs in sea urchin development

Authors:
Xu D, Wavreil FDM, Waldron A, Yajima M
Citation:
Dev Dyn. 2021 Aug;250(8):1160-1172. doi: 10.1002/dvdy.316. Epub 2021 Mar 4
Epub:
Not Epub
Abstract:
Background: Doublecortin-like kinase1 and 2 (DCLKs) are protein Ser/Thr kinases important for neuronal development. More...
Organism or Cell Type:
sea urchin
Citation Extract:
Xu D, Wavreil FDM, Waldron A, Yajima M. Functional contribution of DCLKs in sea urchin development. Dev Dyn. 2021 Aug;250(8):1160-1172. doi: 10.1002/dvdy.316. Epub 2021 Mar 4.

The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm

Authors:
Koopman CD, De Angelis J, Iyer SP, Verkerk AO, Da Silva J, Berecki G, Jeanes A, Baillie GJ, Paterson S, Uribe V, Ehrlich OV, Robinson SD, Garric L, Petrou S, Simons C, Vetter I, Hogan BM, de Boer TP, Bakkers J, Smith KA
Citation:
Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2018220118. doi: 10.1073/pnas.2018220118
Epub:
Not Epub
Abstract:
The establishment of cardiac function in the developing embryo is essential to ensure blood flow and, therefore, growth and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Koopman CD, De Angelis J, Iyer SP, Verkerk AO, Da Silva J, Berecki G, Jeanes A, Baillie GJ, Paterson S, Uribe V, Ehrlich OV, Robinson SD, Garric L, Petrou S, Simons C, Vetter I, Hogan BM, de Boer TP, Bakkers J, Smith KA. The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm. Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2018220118. doi: 10.1073/pnas.2018220118.

IGF-2 mRNA binding protein 2 regulates primordial germ cell development in zebrafish

Authors:
Li M, Rong X, Lu L, Li Y, Yao K, Ge W, Duan C
Citation:
Gen Comp Endocrinol. 2021 Nov 1;313:113875. doi: 10.1016/j.ygcen.2021.113875. Epub 2021 Aug 2
Epub:
Not Epub
Abstract:
Insulin-like growth factor 2 mRNA binding protein-2 (IGF2BP2 or IMP2) is a member of a conserved family of RNA binding proteins...
Organism or Cell Type:
zebrafish
Citation Extract:
Li M, Rong X, Lu L, Li Y, Yao K, Ge W, Duan C. IGF-2 mRNA binding protein 2 regulates primordial germ cell development in zebrafish. Gen Comp Endocrinol. 2021 Nov 1;313:113875. doi: 10.1016/j.ygcen.2021.113875. Epub 2021 Aug 2.

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