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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9876 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Lnc-ECAL-1 controls cerebrovascular homeostasis by targeting endothelium-specific tight junction protein Cldn5b

Authors:
Li F-F, Liang Y-L, Zhang J-J, Jing Q
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.30.926279
Abstract:
Cerebrovascular disorder-induced brain blood flow interruption or intracranial hemorrhage pose a great threaten to health....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li F-F, Liang Y-L, Zhang J-J, Jing Q. Lnc-ECAL-1 controls cerebrovascular homeostasis by targeting endothelium-specific tight junction protein Cldn5b. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.30.926279 .

Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted PGCs

Authors:
Zhang F, Li X, He M, Ye D, Xiong F, Amin G, Zhu Z, Sun Y
Citation:
J Genet Genom. 2020;[Epub] doi:10.1016/j.jgg.2019.12.004
Abstract:
The CRISPR/Cas9 technology has been widely utilized for knocking out genes involved in various biological processes in...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang F, Li X, He M, Ye D, Xiong F, Amin G, Zhu Z, Sun Y. Efficient generation of zebrafish maternal-zygotic mutants through transplantation of ectopically induced and Cas9/gRNA targeted PGCs. J Genet Genom. 2020;[Epub] doi:10.1016/j.jgg.2019.12.004.

Bicc1 and dicer regulate left-right patterning through post-transcriptional control of the Nodal-inhibitor dand5.

Authors:
Maerker M, Getwan M, Dowdle ME, Pelliccia JL, McSheene JC, Yartseva V, Minegishi K, Vick P, Giraldez AJ, Hamada H, Burdine RD, Sheets MD, Schweickert A, Blum M.
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.29.924456
Abstract:
Rotating cilia at the vertebrate left-right organizer (LRO) generate an asymmetric leftward flow, which is sensed by cells at...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish, Xenopus laevis
Citation Extract:
Maerker M, Getwan M, Dowdle ME, Pelliccia JL, McSheene JC, Yartseva V, Minegishi K, Vick P, Giraldez AJ, Hamada H, Burdine RD, Sheets MD, Schweickert A, Blum M.. Bicc1 and dicer regulate left-right patterning through post-transcriptional control of the Nodal-inhibitor dand5. . bioRxiv. 2020;[preprint] doi:10.1101/2020.01.29.924456.

Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish

Authors:
Sharma P, Gupta S, Chaudhary M, Mitra S, Chawla B, Khursheed MA, Saran NK, Ramachandran R
Citation:
iScience. 2020 Jan 7;23(2):100817. doi: 10.1016/j.isci.2019.100817. [Epub ahead of print]
Abstract:
Tgf-β signaling is a major antiproliferative pathway governing different biological functions, including cellular reprogramming...
Delivery Method:
injection then electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Sharma P, Gupta S, Chaudhary M, Mitra S, Chawla B, Khursheed MA, Saran NK, Ramachandran R. Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish. iScience. 2020 Jan 7;23(2):100817. doi: 10.1016/j.isci.2019.100817. [Epub ahead of print].

The regulatory proteins DSCR6 and Ezh2 oppositely regulate Stat3 transcriptional activity in mesoderm patterning during Xenopus development

Authors:
Loreti M, Shi DL, Carron C
Citation:
J Biol Chem. 2020 Jan 29. pii: jbc.RA119.010719. doi: 10.1074/jbc.RA119.010719. [Epub ahead of print]
Abstract:
Embryonic cell fate specification and axis patterning requires integration of several signaling pathways that orchestrate...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Loreti M, Shi DL, Carron C. The regulatory proteins DSCR6 and Ezh2 oppositely regulate Stat3 transcriptional activity in mesoderm patterning during Xenopus development. J Biol Chem. 2020 Jan 29. pii: jbc.RA119.010719. doi: 10.1074/jbc.RA119.010719. [Epub ahead of print].

Greb1 is required for axial elongation and segmentation in vertebrate embryos

Authors:
Prajapati RS, Mitter R, Vezzaro A, Ish-Horowicz D
Citation:
Biol Open. 2020 Jan 27. pii: bio.047290. doi: 10.1242/bio.047290. [Epub ahead of print]
Abstract:
During vertebrate embryonic development, the formation of axial structures is driven by a population of stem-like cells that...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Prajapati RS, Mitter R, Vezzaro A, Ish-Horowicz D. Greb1 is required for axial elongation and segmentation in vertebrate embryos. Biol Open. 2020 Jan 27. pii: bio.047290. doi: 10.1242/bio.047290. [Epub ahead of print].

Morpholino Target Molecular Properties Affect the Swelling Process of Oligomorpholino-Functionalized Responsive Hydrogels

Authors:
Parelius Jonášová E, Stokke BT
Citation:
Polymers (Basel). 2020 Jan 26;12(2). pii: E268. doi: 10.3390/polym12020268
Abstract:
Responsive hydrogels featuring DNA as a functional unit are attracting increasing interest due to combination of versatility...
Citation Extract:
Parelius Jonášová E, Stokke BT. Morpholino Target Molecular Properties Affect the Swelling Process of Oligomorpholino-Functionalized Responsive Hydrogels. Polymers (Basel). 2020 Jan 26;12(2). pii: E268. doi: 10.3390/polym12020268.

Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway

Authors:
Sun X, Zhou Y, Zhang R, Wang Z, Xu M, Zhang D, Huang J, Luo F, Li F, Ni Z, Zhou S, Chen H, Chen S, Chen L, Du X, Chen B, Huang H, Liu P, Yin L, Qiu J, Chen D, Deng C, Xie Y, Luo L, Chen L
Citation:
Nat Comm. 2020;11(1):479 doi:10.1038/s41467-019-14169-z
Abstract:
Congenital scoliosis (CS) is a complex genetic disorder characterized by vertebral malformations. The precise etiology of CS is...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sun X, Zhou Y, Zhang R, Wang Z, Xu M, Zhang D, Huang J, Luo F, Li F, Ni Z, Zhou S, Chen H, Chen S, Chen L, Du X, Chen B, Huang H, Liu P, Yin L, Qiu J, Chen D, Deng C, Xie Y, Luo L, Chen L. Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway. Nat Comm. 2020;11(1):479 doi:10.1038/s41467-019-14169-z.

Hmx3a does not require its homeodomain for its essential functions in spinal cord, ear and lateral line development

Authors:
England SJ, Cerda GA, Kowalchuk AM, Sorice T, Grieb GM, Lewis KE
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.01.23.917468
Abstract:
Homeodomain-containing transcription factors have crucial functions in most aspects of cellular function and embryonic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
England SJ, Cerda GA, Kowalchuk AM, Sorice T, Grieb GM, Lewis KE. Hmx3a does not require its homeodomain for its essential functions in spinal cord, ear and lateral line development. bioRxiv. 2020;[preprint] doi:10.1101/2020.01.23.917468.

A Novel Recessive TNNT1 Congenital Core-Rod Myopathy in French Canadians

Authors:
Pellerin D, Aykanat A, Ellezam B, Troiano EC, Karamchandani J, Dicaire MJ, Petitclerc M, Robertson R, Allard-Chamard X, Brunet D, Konersman CG, Mathieu J, Warman Chardon J, Gupta VA, Beggs AH, Brais B, Chrestian N
Citation:
Ann Neurol. 2020 Jan 22. doi: 10.1002/ana.25685. [Epub ahead of print]
Abstract:
OBJECTIVE: Recessive null variants of the slow skeletal muscle troponin T1 (TNNT1) gene are a rare cause of nemaline myopathy...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pellerin D, Aykanat A, Ellezam B, Troiano EC, Karamchandani J, Dicaire MJ, Petitclerc M, Robertson R, Allard-Chamard X, Brunet D, Konersman CG, Mathieu J, Warman Chardon J, Gupta VA, Beggs AH, Brais B, Chrestian N. A Novel Recessive TNNT1 Congenital Core-Rod Myopathy in French Canadians. Ann Neurol. 2020 Jan 22. doi: 10.1002/ana.25685. [Epub ahead of print].

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