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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10930 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

RNA Toxicity and Perturbation of rRNA Processing in Spinocerebellar Ataxia Type 2

Authors:
Li PP, Moulick R, Feng H, Sun X, Arbez N, Jin J, Marque LO, Hedglen E, Chan HYE, Ross CA, Pulst SM, Margolis RL, Woodson S, Rudnicki DD
Citation:
Mov Disord. 2021 Aug 14. doi: 10.1002/mds.28729. Online ahead of print
Epub:
Not Epub
Abstract:
Background: Spinocerebellar ataxia type 2 (SCA2) is a neurodegenerative disease caused by expansion of a CAG repeat in Ataxin-2...
Citation Extract:
Li PP, Moulick R, Feng H, Sun X, Arbez N, Jin J, Marque LO, Hedglen E, Chan HYE, Ross CA, Pulst SM, Margolis RL, Woodson S, Rudnicki DD. RNA Toxicity and Perturbation of rRNA Processing in Spinocerebellar Ataxia Type 2. Mov Disord. 2021 Aug 14. doi: 10.1002/mds.28729. Online ahead of print.

Zebrafish Model as a Screen to Prevent Cyst Inflation in Autosomal Dominant Polycystic Kidney Disease

Authors:
Oliveira I, Jacinto R, Pestana S, Nolasco F, Calado J, Lopes SS, Roxo-Rosa M
Citation:
Int J Mol Sci. 2021 Aug 20;22(16):9013. doi: 10.3390/ijms22169013
Epub:
Not Epub
Abstract:
In autosomal dominant polycystic kidney disease (ADPKD), kidney cyst growth requires the recruitment of CFTR (cystic fibrosis...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oliveira I, Jacinto R, Pestana S, Nolasco F, Calado J, Lopes SS, Roxo-Rosa M. Zebrafish Model as a Screen to Prevent Cyst Inflation in Autosomal Dominant Polycystic Kidney Disease. Int J Mol Sci. 2021 Aug 20;22(16):9013. doi: 10.3390/ijms22169013.

Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification

Authors:
Liu KC, Villasenor A, Bertuzzi M, Schmitner N, Radros N, Rautio L, Mattonet K, Matsuoka RL, Reischauer S, Stainier DY, Andersson O
Citation:
Elife. 2021 Aug 17;10:e65758. doi: 10.7554/eLife.65758
Epub:
Not Epub
Abstract:
To investigate the role of the vasculature in pancreatic β-cell regeneration, we crossed a zebrafish β-cell ablation model into...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu KC, Villasenor A, Bertuzzi M, Schmitner N, Radros N, Rautio L, Mattonet K, Matsuoka RL, Reischauer S, Stainier DY, Andersson O. Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification. Elife. 2021 Aug 17;10:e65758. doi: 10.7554/eLife.65758.

Dual SMN inducing therapies can rescue survival and motor unit function in symptomatic ∆7SMA mice

Authors:
Kray KM, McGovern VL, Chugh D, Arnold WD, Burghes AHM
Citation:
Neurobiol Dis. 2021 Aug 20;159:105488. doi: 10.1016/j.nbd.2021.105488. Online ahead of print
Epub:
Not Epub
Abstract:
Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by survival motor neuron (SMN) protein deficiency...
Delivery Method:
intracerebroventricular (icv) injection
Organism or Cell Type:
mice
Citation Extract:
Kray KM, McGovern VL, Chugh D, Arnold WD, Burghes AHM. Dual SMN inducing therapies can rescue survival and motor unit function in symptomatic ∆7SMA mice. Neurobiol Dis. 2021 Aug 20;159:105488. doi: 10.1016/j.nbd.2021.105488. Online ahead of print.

The alternative oxidase (AOX) increases sulphide tolerance in the highly invasive marine invertebrate Ciona intestinalis

Authors:
Bremer K, Yasuo H, Debes PV, Jacobs HT
Citation:
J Exp Biol. 2021 Aug 15;224(16):jeb242985. doi: 10.1242/jeb.242985. Epub 2021 Aug 26
Epub:
Not Epub
Abstract:
Ecological communities and biodiversity are shaped by both abiotic and biotic factors. This is well illustrated by extreme...
Delivery Method:
microinjection
Organism or Cell Type:
Ciona intestinalis
Citation Extract:
Bremer K, Yasuo H, Debes PV, Jacobs HT. The alternative oxidase (AOX) increases sulphide tolerance in the highly invasive marine invertebrate Ciona intestinalis. J Exp Biol. 2021 Aug 15;224(16):jeb242985. doi: 10.1242/jeb.242985. Epub 2021 Aug 26.

Vivo-Morpholino-Based Antiviral for SARS-CoV-2: Implications for Novel Therapies in the Treatment of Acute COVID-19 Disease

Authors:
Hildreth JEK, Moulton JD, Alcendor DJ
Citation:
Biomedicines. 2021;9(8):1018. doi:10.3390/biomedicines9081018
Epub:
Not Epub
Abstract:
Therapeutic modalities designed specifically to inhibit COVID-19 infection and replication would limit progressive COVID-19-...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: Vero E6
Citation Extract:
Hildreth JEK, Moulton JD, Alcendor DJ. Vivo-Morpholino-Based Antiviral for SARS-CoV-2: Implications for Novel Therapies in the Treatment of Acute COVID-19 Disease. Biomedicines. 2021;9(8):1018. doi:10.3390/biomedicines9081018.

Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability

Authors:
Bengani H, Grozeva D, Moyon L, Bhatia S, Louros SR, Hope J, Jackson A, Prendergast JG, Owen LJ, Naville M, Rainger J, Grimes G, Halachev M, Murphy, Spasic-Boskovic O, van Heyningen V, Kind P, Abbott CM, Osterweil E, Raymond FL, Crollius HR, FitzPatrick DR
Citation:
PLoS ONE. 2021;16(8):e0256181. doi:journal.pone.0256181
Epub:
Not Epub
Abstract:
Identifying causative variants in cis-regulatory elements (CRE) in neurodevelopmental disorders has proven challenging. We have...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bengani H, Grozeva D, Moyon L, Bhatia S, Louros SR, Hope J, Jackson A, Prendergast JG, Owen LJ, Naville M, Rainger J, Grimes G, Halachev M, Murphy, Spasic-Boskovic O, van Heyningen V, Kind P, Abbott CM, Osterweil E, Raymond FL, Crollius HR, FitzPatrick DR. Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability. PLoS ONE. 2021;16(8):e0256181. doi:journal.pone.0256181.

Zebrafish Cdx4 regulates neural crest cell specification and migratory behaviors in the posterior body

Authors:
Rocha M, Kushkowski E, Schnirman R, Booth C, Singh N, Beadell A, Prince VE
Citation:
Dev Bio. 2021;[Epub} doi:10.1016/j.ydbio.2021.08.002
Epub:
Not Epub
Abstract:
The neural crest (NC) is a transient multipotent cell population that migrates extensively to produce a remarkable array of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rocha M, Kushkowski E, Schnirman R, Booth C, Singh N, Beadell A, Prince VE. Zebrafish Cdx4 regulates neural crest cell specification and migratory behaviors in the posterior body. Dev Bio. 2021;[Epub} doi:10.1016/j.ydbio.2021.08.002.

Open reading frame correction using antisense oligonucleotides for the treatment of cystic fibrosis caused by CFTR-W1282X

Authors:
Michaels WE, Pena-Rasgado C, Kotaria R, Bridges RJ, Hastings ML
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.08.11.455834
Epub:
Not Epub
Abstract:
CFTR gene mutations that result in the introduction of premature termination codons (PTCs) are common in cystic fibrosis (CF)....
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: CFTR-W1282X bronchial epithelial line, primary CFTR-W1282X epithelial cells
Citation Extract:
Michaels WE, Pena-Rasgado C, Kotaria R, Bridges RJ, Hastings ML. Open reading frame correction using antisense oligonucleotides for the treatment of cystic fibrosis caused by CFTR-W1282X. bioRxiv. 2021;[preprint] doi:10.1101/2021.08.11.455834.

Dietary Nucleotides Alleviate Hepatic Lipid Deposition via Exogenous AMP-Mediated AMPK Activation in Zebrafish

Authors:
Ran C, Xie M, Li J, Xie Y, Ding Q, Li Y, Zhou W, Yang Y, Zhang Z, Olsen RE, Zhou Z
Citation:
J Nutr. 2021;nxab232 {Epub] doi:doi.org/10.1093/jn/nxab232
Epub:
Yes
Abstract:
Background: Dietary nucleotides (NTs) have been reported to affect hepatic function and composition. However, the effects on...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Ran C, Xie M, Li J, Xie Y, Ding Q, Li Y, Zhou W, Yang Y, Zhang Z, Olsen RE, Zhou Z. Dietary Nucleotides Alleviate Hepatic Lipid Deposition via Exogenous AMP-Mediated AMPK Activation in Zebrafish. J Nutr. 2021;nxab232 {Epub] doi:doi.org/10.1093/jn/nxab232.

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