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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12175 scientific papers returned from the database with the search filters currently being used below.
There are 12175 scientific papers returned from the database with the search filters currently being used below.
Elp1 function in placode-derived neurons is critical for proper trigeminal ganglion development
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Citation:
bioRxiv [preprint] 2024.07.12.603323; doi: https://doi.org/10.1101/2024.07.12.603323 Epub:
Not Epub Abstract:
The trigeminal nerve is the largest cranial nerve and functions in somatosensation. Cell bodies of this nerve are positioned... Delivery Method:
electroporation Organism or Cell Type:
chick embryo Citation Extract: Hines MA & Taneyhill LA. Elp1 function in placode-derived neurons is critical for proper trigeminal ganglion development. bioRxiv [preprint] 2024.07.12.603323; doi: https://doi.org/10.1101/2024.07.12.603323. |
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing
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Citation:
Nat Cell Biol. 2024 Jul 18. doi: 10.1038/s41556-024-01460-5. Epub ahead of print. PMID: 39025928. Epub:
Not Epub Abstract:
OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is amplified in a subset of tumours and... Delivery Method:
Pre-treat cells then cerebellum injection into NOD-SCID mice Organism or Cell Type:
HDMB03 and MB3W1 cell line-derived tumourspheres Citation Extract: Saulnier O, Zagozewski J, Liang L, Hendrikse LD, Layug P, Gordon V, Aldinger KA, Haldipur P, Borlase S, Coudière-Morrison L, Cai T, Martell E, Gonzales NM, Palidwor G, Porter CJ, Richard S, Sharif T, Millen KJ, Doble BW, Taylor MD, Werbowetski-Ogilvie TE. A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing. Nat Cell Biol. 2024 Jul 18. doi: 10.1038/s41556-024-01460-5. Epub ahead of print. PMID: 39025928.. |
The Usefulness of Determining Plasma and Tissue Concentrations of Phosphorodiamidate Morpholino Oligonucleotides to Estimate Their Efficacy in Duchenne Muscular Dystrophy Patients
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Citation:
Drug Metab Dispos. 2024 Aug 14;52(9):1029-1036. doi: 10.1124/dmd.124.001806. PMID: 38991781 Epub:
Not Epub Abstract:
Currently four kinds of phosphorodiamidate morpholino oligomers (PMOs) such as viltolarsen have been approved for the treatment... Delivery Method:
i.v. bolus injection (mice), i.v. infusion and bolus injection (monkey) Organism or Cell Type:
mice (mdx): C57BL/10ScSn-DmdmdxJ, Cynomolgus monkeys Citation Extract: Imai S, Watanabe N, Tone Y, Mitamura R, Mori J, Kameyama T, Yamada T, Kusano K. The Usefulness of Determining Plasma and Tissue Concentrations of Phosphorodiamidate Morpholino Oligonucleotides to Estimate Their Efficacy in Duchenne Muscular Dystrophy Patients. Drug Metab Dispos. 2024 Aug 14;52(9):1029-1036. doi: 10.1124/dmd.124.001806. PMID: 38991781. |
Biallelic variants in POPDC2 cause a novel autosomal recessive syndrome presenting with cardiac conduction defects and variable hypertrophic cardiomyopathy
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Citation:
medRxiv [preprint] 2024.07.04.24309755 Epub:
Not Epub Abstract:
POPDC2 encodes for the Popeye domain-containing protein 2 which has an important role in cardiac pacemaking and conduction, due... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Nicastro M, Vermeer Alexa MC, Postema PG,Tadros R, Bowling FZ, Aegisdottir, HM, et al.. Biallelic variants in POPDC2 cause a novel autosomal recessive syndrome presenting with cardiac conduction defects and variable hypertrophic cardiomyopathy. medRxiv [preprint] 2024.07.04.24309755. |
Molecular analysis of a self-organizing signaling pathway for Xenopus axial patterning from egg to tailbud
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Citation:
Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2408346121. doi: 10.1073/pnas.2408346121. Epub 2024 Jul 5. PMID: 38968117 Epub:
Not Epub Abstract:
Xenopus embryos provide a favorable material to dissect the sequential steps that lead to dorsal-ventral (D-V) and anterior-... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Azbazdar Y, De Robertis EM. Molecular analysis of a self-organizing signaling pathway for Xenopus axial patterning from egg to tailbud. Proc Natl Acad Sci U S A. 2024 Jul 9;121(28):e2408346121. doi: 10.1073/pnas.2408346121. Epub 2024 Jul 5. PMID: 38968117. |
Evolution and host-specific adaptation of Pseudomonas aeruginosa
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Citation:
Science. 2024 Jul 5;385(6704):eadi0908. doi: 10.1126/science.adi0908. Epub 2024 Jul 5. PMID: 38963857 Epub:
Not Epub Abstract:
The major human bacterial pathogen Pseudomonas aeruginosa causes multidrug-resistant infections in people with underlying... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Weimann A, Dinan AM, Ruis C, Bernut A, Pont S, Brown K, Ryan J, Santos L, Ellison L, Ukor E, Pandurangan AP, Krokowski S, Blundell TL, Welch M, Blane B, Judge K, Bousfield R, Brown N, Bryant JM, Kukavica-Ibrulj I, Rampioni G, Leoni L, Harrison PT, Peacock SJ, Thomson NR, Gauthier J, Fothergill JL, Levesque RC, Parkhill J, Floto RA. Evolution and host-specific adaptation of Pseudomonas aeruginosa. Science. 2024 Jul 5;385(6704):eadi0908. doi: 10.1126/science.adi0908. Epub 2024 Jul 5. PMID: 38963857. |
Perfluorooctane Sulfonamide Induced Autotoxic Effects on the Zebrafish Immune System
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Citation:
Environ Sci Technol. 2024 Jul 8 Epub:
Not Epub Abstract:
Perfluorooctane sulfonamide (PFOSA) is an immediate perfluorooctanesulfonate (PFOS) precursor (PreFOS). Previous studies have... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chen H, Zou Y, Kang X, Yang G, Yang X, Yao Y, Magnuson JT, Cao X, Qiu W, Xu EG, Zheng C. Perfluorooctane Sulfonamide Induced Autotoxic Effects on the Zebrafish Immune System. Environ Sci Technol. 2024 Jul 8. |
Variants of NAV3, a neuronal morphogenesis protein, cause intellectual disability, developmental delay, and microcephaly
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Citation:
Commun Biol. 2024 Jul 8;7(1):831 Epub:
Not Epub Abstract:
Microtubule associated proteins (MAPs) are widely expressed in the central nervous system, and have established roles in cell... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ghaffar A, Akhter T, Strømme P, Misceo D, Khan A, Frengen E, Umair M, Isidor B, Cogné B, Khan AA, Bruel AL, Sorlin A, Kuentz P, Chiaverini C, Innes AM, Zech M, Baláž M, Havrankova P, Jech R, Ahmed ZM, Riazuddin S, Riazuddin S. Variants of NAV3, a neuronal morphogenesis protein, cause intellectual disability, developmental delay, and microcephaly. Commun Biol. 2024 Jul 8;7(1):831. |
The intracellular domain of Sema6A is essential for development of the zebrafish retina
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Citation:
J Cell Sci jcs.261469 Epub:
Not Epub Abstract:
Semaphorin6A (Sema6A) is a repulsive guidance molecule that plays many roles in central nervous system, heart, and bone... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Dumas CM, St. Clair RM, Lasseigne AM, Ballif BA, Ebert AM. The intracellular domain of Sema6A is essential for development of the zebrafish retina. J Cell Sci jcs.261469. |
Oxysterol-binding protein like 7 deficiency leads to ER stress mediated apoptosis in podocytes and proteinuria
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Citation:
Am J Physiol Renal Physiol. 2024 Jul 4 Epub:
Not Epub Abstract:
Chronic kidney disease (CKD) is associated with renal lipid dysmetabolism among a variety of other pathways. We recently... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Duara J, Torres MF, Gurumani M, Molina David J, Njeim R, Kim JJ, Mitrofanova A, Ge M, Sloan AJ, Müller-Deile J, Schiffer M, Merscher S, Fornoni A. Oxysterol-binding protein like 7 deficiency leads to ER stress mediated apoptosis in podocytes and proteinuria. Am J Physiol Renal Physiol. 2024 Jul 4. |