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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10468 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Novel nanopolymer RNA therapeutics normalize human diabetic corneal wound healing and epithelial stem cells

Authors:
Kramerov AA, Shah R, Ding H, Holler E, Turjman S, Rabinowitz YS, Ghiam S, Maguen E, Svendsen CN, Saghizadeh M, Ljubimova JY, Ljubimov AV
Citation:
Nanomedicine. 2020;[Epub] doi:10.1016/j.nano.2020.102332
Abstract:
Human diabetic corneas develop delayed wound healing, epithelial stem cell dysfunction, recurrent erosions, and keratitis....
Delivery Method:
nanopolymer
Organism or Cell Type:
cell culture: diabetic limbal epithelial cells; organ culture: cornea
Citation Extract:
Kramerov AA, Shah R, Ding H, Holler E, Turjman S, Rabinowitz YS, Ghiam S, Maguen E, Svendsen CN, Saghizadeh M, Ljubimova JY, Ljubimov AV. Novel nanopolymer RNA therapeutics normalize human diabetic corneal wound healing and epithelial stem cells. Nanomedicine. 2020;[Epub] doi:10.1016/j.nano.2020.102332.

The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina

Authors:
Toulis V, García-Monclús S, de la Peña-Ramírez C, Arenas-Galnares R, Abril JF, Todi SV, Khan N, Garanto A, Costa MDC, Marfany G
Citation:
Cell Rep. 2020 Nov 10;33(6):108360. doi: 10.1016/j.celrep.2020.108360
Abstract:
Expansion of a CAG repeat in ATXN3 causes the dominant polyglutamine disease spinocerebellar ataxia type 3 (SCA3), yet the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Toulis V, García-Monclús S, de la Peña-Ramírez C, Arenas-Galnares R, Abril JF, Todi SV, Khan N, Garanto A, Costa MDC, Marfany G. The Deubiquitinating Enzyme Ataxin-3 Regulates Ciliogenesis and Phagocytosis in the Retina. Cell Rep. 2020 Nov 10;33(6):108360. doi: 10.1016/j.celrep.2020.108360.

Ppargc1a Controls Ciliated Cell Development by Regulating Prostaglandin Biosynthesis

Authors:
Chambers JM, Addiego A, Flores-Mireles AL, Wingert RA
Citation:
Cell Rep. 2020;22(6):108370. doi:10.1016/j.celrep.2020.108370
Abstract:
Cilia are microtubule-based organelles that function in a multitude of physiological contexts to perform chemosensing,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chambers JM, Addiego A, Flores-Mireles AL, Wingert RA. Ppargc1a Controls Ciliated Cell Development by Regulating Prostaglandin Biosynthesis. Cell Rep. 2020;22(6):108370. doi:10.1016/j.celrep.2020.108370.

AML poor prognosis factor, TPD52, is associated with the maintenance of haematopoietic stem cells through regulation of cell proliferation

Authors:
Kang JW, Kim Y, Lee Y, Myung K, Kim YH, Oh CK
Citation:
J Cell Biochem. 2020 Nov 9. doi: 10.1002/jcb.29869. Online ahead of print
Abstract:
Acute myeloid leukaemia (AML) is a blood cancer where undifferentiated myeloid cells are increased in the bone marrow and...
Organism or Cell Type:
zebrafish
Citation Extract:
Kang JW, Kim Y, Lee Y, Myung K, Kim YH, Oh CK. AML poor prognosis factor, TPD52, is associated with the maintenance of haematopoietic stem cells through regulation of cell proliferation. J Cell Biochem. 2020 Nov 9. doi: 10.1002/jcb.29869. Online ahead of print.

A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AαE in early hemostasis

Authors:
Freire C, Fish RJ, Vilar R, Di Sanza C, Grzegorski SJ, Richter CE, Shavit JA, Neerman-Arbez M
Citation:
Blood Adv. 2020;4(21):5480–5491. doi:10.1182/bloodadvances.2020001472
Abstract:
Plasma fibrinogen molecules comprise 2 copies of Aα, Bβ, and γ chains folded into a hexameric protein. A minor fibrinogen...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Freire C, Fish RJ, Vilar R, Di Sanza C, Grzegorski SJ, Richter CE, Shavit JA, Neerman-Arbez M. A genetic modifier of venous thrombosis in zebrafish reveals a functional role for fibrinogen AαE in early hemostasis. Blood Adv. 2020;4(21):5480–5491. doi:10.1182/bloodadvances.2020001472.

MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome

Authors:
Fasciani A, D’Annunzio S, Poli V, Fagnocchi L, Beyes S, Michelatti D, Corazza F, Antonelli L, Gregoretti F, Oliva G, Belli R, Peroni D, Domenici E, Zambrano S, Intartaglia D, Settembre C, Conte I, Testi C, Vergyris P, Ruocco G, Zippo A
Citation:
Nat Genet. 2020;[Epub ahead of print]. doi:10.1038/s41588-020-00724-8
Abstract:
The genetic elements required to tune gene expression are partitioned in active and repressive nuclear condensates. Chromatin...
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Fasciani A, D’Annunzio S, Poli V, Fagnocchi L, Beyes S, Michelatti D, Corazza F, Antonelli L, Gregoretti F, Oliva G, Belli R, Peroni D, Domenici E, Zambrano S, Intartaglia D, Settembre C, Conte I, Testi C, Vergyris P, Ruocco G, Zippo A. MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome. Nat Genet. 2020;[Epub ahead of print]. doi:10.1038/s41588-020-00724-8.

A generic assay for the identification of splicing variants that induce nonsense-mediated decay in Pompe disease

Authors:
Bergsma AJ, in ’t Groen SLM, Catalano F, Yamanaka M, Takahashi S, Okumiya T, van der Ploeg AT, Pijnappel WWMP
Citation:
Eur J Hum Genet. 2020;{Epub ahead of print]. doi:10.1038/s41431-020-00751-3
Abstract:
DNA variants affecting mRNA expression and processing in genetic diseases are often missed or poorly characterized. We...
Delivery Method:
Endo-Porter DMSO
Organism or Cell Type:
cell culture: human primary fibroblasts
Citation Extract:
Bergsma AJ, in ’t Groen SLM, Catalano F, Yamanaka M, Takahashi S, Okumiya T, van der Ploeg AT, Pijnappel WWMP. A generic assay for the identification of splicing variants that induce nonsense-mediated decay in Pompe disease. Eur J Hum Genet. 2020;{Epub ahead of print]. doi:10.1038/s41431-020-00751-3.

Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers

Authors:
Rosenke K, Leventhal S, Moulton H, Hatlevig S, Hawman D, Feldmann H, Stein DA
Citation:
J Antimicrob Chemother. 2020;[Epub ahead of print]:dkaa460 doi:10.1093/jac/dkaa460
Abstract:
Background: As the causative agent of COVID-19, SARS-CoV-2 is a pathogen of immense importance to global public health....
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Vero-E6 and SARS-CoV-2
Citation Extract:
Rosenke K, Leventhal S, Moulton H, Hatlevig S, Hawman D, Feldmann H, Stein DA. Inhibition of SARS-CoV-2 in Vero cell cultures by peptide-conjugated morpholino-oligomers. J Antimicrob Chemother. 2020;[Epub ahead of print]:dkaa460 doi:10.1093/jac/dkaa460.

Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells

Authors:
Lefkopoulos S, Polyzou A, Derecka M, Bergo V, Clapes T, Cauchy P, Jerez-Longres C, Onishi-Seebacher M, Yin N, Martagon-Calderón N-A, Potts KS, Klaeylé L, Liu F, Bowman TV, Jenuwein T, Mione MC, Trompouki E
Citation:
Immunity. 2020;[Epub ahead of print] doi:10.1016/j.immuni.2020.10.007
Abstract:
Inflammatory signaling is required for hematopoietic stem and progenitor cell (HSPC) development. Here, we studied the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lefkopoulos S, Polyzou A, Derecka M, Bergo V, Clapes T, Cauchy P, Jerez-Longres C, Onishi-Seebacher M, Yin N, Martagon-Calderón N-A, Potts KS, Klaeylé L, Liu F, Bowman TV, Jenuwein T, Mione MC, Trompouki E. Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells. Immunity. 2020;[Epub ahead of print] doi:10.1016/j.immuni.2020.10.007.

Cohesin components Stag1 and Stag2 differentially influence haematopoietic mesoderm development in zebrafish embryos

Authors:
Ketharnathan S, Labudina A, Horsfield JA
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.10.19.346122
Abstract:
Cohesin is a multiprotein complex made up of core subunits Smc1, Smc3 and Rad21, and either Stag1 or Stag2. Normal...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ketharnathan S, Labudina A, Horsfield JA. Cohesin components Stag1 and Stag2 differentially influence haematopoietic mesoderm development in zebrafish embryos. bioRxiv. 2020;[preprint] doi:10.1101/2020.10.19.346122.

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