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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11902 scientific papers returned from the database with the search filters currently being used below.

Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome

Authors:
Blue EE, White JJ, Dush MK, Gordon WW, Wyatt BH, White P, Marvin CT, Helle E, Ojala T, Priest JR, Jenkins MM, Almli LM, Reefhuis J, Pangilinan F, Brody LC, McBride KL, Garg V, Shaw GM, Romitti PA, Nembhard WN, Browne ML, Werler MM, Kay DM, Mital S, Chong JX, Nascone-Yoder NM, Bamshad MJ
Citation:
Hum Genet Genom Adv. 2023;4(4):100232. doi:10.1016/j.xhgg.2023.100232
Epub:
Not Epub
Abstract:
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart defect (CHD) characterized by hypoplasia of the left...
Link:
https://www.cell.com/cms/10.1016/j.xhgg.2023.100232/attachment/21afb3a1-a16f-418d-9d4a-525c460d1bd8/mmc1.pdf
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Blue EE, White JJ, Dush MK, Gordon WW, Wyatt BH, White P, Marvin CT, Helle E, Ojala T, Priest JR, Jenkins MM, Almli LM, Reefhuis J, Pangilinan F, Brody LC, McBride KL, Garg V, Shaw GM, Romitti PA, Nembhard WN, Browne ML, Werler MM, Kay DM, Mital S, Chong JX, Nascone-Yoder NM, Bamshad MJ . Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome. Hum Genet Genom Adv. 2023;4(4):100232. doi:10.1016/j.xhgg.2023.100232.

Loss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy

Authors:
Karolczak S, Deshwar AR, Aristegui E, Kamath BM, Lawlor MW, Andreoletti G, Volpatti JR, Ellis JL, Yin C, Dowling JJ
Citation:
J Clin Invest. 2023 Jul 25:e166275. doi: 10.1172/JCI166275. Online ahead of print
Epub:
Yes
Abstract:
X-linked myotubular myopathy (XLMTM) is a fatal congenital disorder caused by mutations in the MTM1 gene. Currently, there are...
Link:
https://www.jci.org/articles/view/166275
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Karolczak S, Deshwar AR, Aristegui E, Kamath BM, Lawlor MW, Andreoletti G, Volpatti JR, Ellis JL, Yin C, Dowling JJ. Loss of Mtm1 causes cholestatic liver disease in a model of X-linked myotubular myopathy. J Clin Invest. 2023 Jul 25:e166275. doi: 10.1172/JCI166275. Online ahead of print.

Paracrine regulation of neural crest EMT by placodal MMP28

Authors:
Gouignard N, Bibonne A, Mata JF, Bajanca F, Berki B, Barriga EH, Saint-Jeannet JP, Theveneau E
Citation:
PLoS Biol. 2023 Aug 17;21(8):e3002261. doi: 10.1371/journal.pbio.3002261. Online ahead of print
Epub:
Not Epub
Abstract:
Epithelial–mesenchymal transition (EMT) is an early event in cell dissemination from epithelial tissues. EMT endows cells with...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002261
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Gouignard N, Bibonne A, Mata JF, Bajanca F, Berki B, Barriga EH, Saint-Jeannet JP, Theveneau E. Paracrine regulation of neural crest EMT by placodal MMP28. PLoS Biol. 2023 Aug 17;21(8):e3002261. doi: 10.1371/journal.pbio.3002261. Online ahead of print.

“Plod2” a Lysyl Hydroxylase Required for HSC Specification

Authors:
Khoury H, Clements W
Citation:
Exp. Hematol. 2023;124 supplement:S101. doi:10.1016/j.exphem.2023.06.209
Epub:
Not Epub
Abstract:
Hematopoietic stem cells (HSCs) are self-renewing precursors that continuously renew hematopoietic lineages during life and...
Link:
https://www.exphem.org/article/S0301-472X(23)01483-2/pdf
Organism or Cell Type:
zebrafish
Citation Extract:
Khoury H, Clements W. “Plod2” a Lysyl Hydroxylase Required for HSC Specification. Exp. Hematol. 2023;124 supplement:S101. doi:10.1016/j.exphem.2023.06.209.

Extracellular Pgk1 interacts neural membrane protein enolase-2 to improve the neurite outgrowth of motor neurons

Authors:
Fu CY, Chen HY, Lin CY, Chen SJ, Sheu JC, Tsai HJ
Citation:
Commun Biol. 2023 Aug 15;6(1):849. doi: 10.1038/s42003-023-05223-0
Epub:
Not Epub
Abstract:
Understanding the molecular interaction between ligand and receptor is important for providing the basis for the development of...
Link:
https://www.nature.com/articles/s42003-023-05223-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fu CY, Chen HY, Lin CY, Chen SJ, Sheu JC, Tsai HJ. Extracellular Pgk1 interacts neural membrane protein enolase-2 to improve the neurite outgrowth of motor neurons. Commun Biol. 2023 Aug 15;6(1):849. doi: 10.1038/s42003-023-05223-0.

Ontogenetically distinct neutrophils differ in function and transcriptional profile in zebrafish

Authors:
García-López JP, Grimaldi A, Chen Z, Meneses C, Bravo-Tello K, Bresciani E, Banderas A, Burgess SM, Hernández PP, Feijoo CG
Citation:
Nat Commun. 2023 Aug 15;14(1):4942. doi: 10.1038/s41467-023-40662-7
Epub:
Not Epub
Abstract:
The current view of hematopoiesis considers leukocytes on a continuum with distinct developmental origins, and which exert non-...
Link:
https://www.nature.com/articles/s41467-023-40662-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
García-López JP, Grimaldi A, Chen Z, Meneses C, Bravo-Tello K, Bresciani E, Banderas A, Burgess SM, Hernández PP, Feijoo CG. Ontogenetically distinct neutrophils differ in function and transcriptional profile in zebrafish. Nat Commun. 2023 Aug 15;14(1):4942. doi: 10.1038/s41467-023-40662-7.

Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle

Authors:
Pollitt EJG, Derrick CJ, Sánchez-Posada J, Noël ES
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.08.14.553249
Epub:
Not Epub
Abstract:
During heart development, the embryonic ventricle becomes enveloped by the epicardium, a layer of mesothelium which adheres to...
Link:
https://www.biorxiv.org/content/10.1101/2023.08.14.553249v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pollitt EJG, Derrick CJ, Sánchez-Posada J, Noël ES. Llgl1 mediates timely epicardial emergence and establishment of an apical laminin sheath around the trabeculating cardiac ventricle. bioRxiv. 2023;[preprint] doi:10.1101/2023.08.14.553249.

Lymphocyte pathway analysis using naturally lymphocyte-deficient fish

Authors:
Zhang G, Swann J, Felder M, O'Meara C, Boehm T
Citation:
Eur J Immunol. 2023 Aug 18:e2350577. doi: 10.1002/eji.202350577. Online ahead of print
Epub:
Yes
Abstract:
Comparative phylogenetic analyses are of potential value to establish the essential components of genetic networks underlying...
Link:
https://onlinelibrary.wiley.com/doi/pdf/10.1002/eji.202350577
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang G, Swann J, Felder M, O'Meara C, Boehm T. Lymphocyte pathway analysis using naturally lymphocyte-deficient fish. Eur J Immunol. 2023 Aug 18:e2350577. doi: 10.1002/eji.202350577. Online ahead of print.

Alternative splicing of its 5’-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies

Authors:
Ang Z, Paruzzo L, Hayer KE, Schmidt C, Diz MT, Xu F, Zankharia U, Zhang Y, Soldan S, Zheng S, Falkenstein CD, Loftus JP, Yang SY, Mukta Asnani, Sainos PK, Pillai V, Chong E, Li MM, Tasian SK, Barash Y, Lieberman PM, Ruella M, Schuster SJ, Thomas-Tikhonenko A
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.02.19.529123
Epub:
Not Epub
Abstract:
Aberrant skipping of coding exons in CD19 and CD22 compromises responses to immunotherapy for B-cell malignancies. Here, we...
Link:
https://www.biorxiv.org/content/10.1101/2023.02.19.529123v3
Delivery Method:
Electroporation, Vivo-Morpholino
Organism or Cell Type:
cell culture: Raji, OCI-Ly8, and MEC-1 cells
Citation Extract:
Ang Z, Paruzzo L, Hayer KE, Schmidt C, Diz MT, Xu F, Zankharia U, Zhang Y, Soldan S, Zheng S, Falkenstein CD, Loftus JP, Yang SY, Mukta Asnani, Sainos PK, Pillai V, Chong E, Li MM, Tasian SK, Barash Y, Lieberman PM, Ruella M, Schuster SJ, Thomas-Tikhonenko A. Alternative splicing of its 5’-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies. bioRxiv. 2023;[preprint] doi:10.1101/2023.02.19.529123 .

Sequence specificity defines the effectiveness of PPMOs targeting Pseudomonas aeruginosa

Authors:
Nanayakkara AK, Moustafa DA, Pifer R, Goldberg JB, Greenberg DE
Citation:
Antimicrob Agents Chemother. 2023 Aug 23:e0024523. doi: 10.1128/aac.00245-23. Online ahead of print
Epub:
Yes
Abstract:
Development of new therapeutics against antibiotic resistant pathogenic bacteria is recognized as a priority across the globe....
Link:
https://journals.asm.org/doi/10.1128/aac.00245-23
Delivery Method:
peptide-linked
Organism or Cell Type:
Pseudomonas aeruginosa (bacterium)
Citation Extract:
Nanayakkara AK, Moustafa DA, Pifer R, Goldberg JB, Greenberg DE. Sequence specificity defines the effectiveness of PPMOs targeting Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2023 Aug 23:e0024523. doi: 10.1128/aac.00245-23. Online ahead of print.

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