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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10704 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Svep1 stabilizes developmental vascular anastomosis in reduced flow conditions

Authors:
Coxam B, Padberg Y, Maier K, Jung S, Bartels-Klein E, Szymborska A, Finotto L, Helker CSM, Stainier DYR, Schulte-Merker S, Gerhardt H
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.13.435246
Abstract:
We report the discovery that flow and Svep1 are modulator of vessel anastomosis during developmental angiogenesis in zebrafish...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Coxam B, Padberg Y, Maier K, Jung S, Bartels-Klein E, Szymborska A, Finotto L, Helker CSM, Stainier DYR, Schulte-Merker S, Gerhardt H. Svep1 stabilizes developmental vascular anastomosis in reduced flow conditions. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.13.435246 .

Dram1 confers resistance to Salmonella infection

Authors:
Masud S, Zhang R, Prajsnar TK, Meijer AH
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.21.436194
Abstract:
Dram1 is a stress and infection inducible autophagy modulator that functions downstream of transcription factors p53 and NFκB....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Masud S, Zhang R, Prajsnar TK, Meijer AH. Dram1 confers resistance to Salmonella infection. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.21.436194.

Lysosomal cholesterol accumulation contributes to the movement phenotypes associated with NUS1 haploinsufficiency

Authors:
Yu S-H, Wang T, Wiggins K, Louie RJ, Merino EF, Skinner C, Cassera MB, Meagher K, Goldberg P, Rismanchi N, Chen D, Lyons MJ, Flanagan-Steet H, Steet R
Citation:
Genet Med. 2021. doi:10.1038/s41436-021-01137-6
Abstract:
Purpose: Variants in NUS1 are associated with a congenital disorder of glycosylation, developmental and epileptic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yu S-H, Wang T, Wiggins K, Louie RJ, Merino EF, Skinner C, Cassera MB, Meagher K, Goldberg P, Rismanchi N, Chen D, Lyons MJ, Flanagan-Steet H, Steet R. Lysosomal cholesterol accumulation contributes to the movement phenotypes associated with NUS1 haploinsufficiency. Genet Med. 2021. doi:10.1038/s41436-021-01137-6.

Clathrin Heavy Chain 1 Plays Essential Roles During Oocyte Meiotic Spindle Formation and Early Embryonic Development in Sheep

Authors:
Han Z, Hao X, Zhou CJ, Wang J, Wen X, Wang XY, Zhang DJ, Liang CG
Citation:
Front Cell Dev Biol. 2021 Feb 25;9:609311. doi:10.3389/fcell.2021.609311. eCollection 2021
Abstract:
As a major protein of the polyhedral coat of coated pits and vesicles, clathrin molecules have been shown to play a...
Delivery Method:
microinjection
Organism or Cell Type:
Ovis aries (sheep oocytes)
Citation Extract:
Han Z, Hao X, Zhou CJ, Wang J, Wen X, Wang XY, Zhang DJ, Liang CG. Clathrin Heavy Chain 1 Plays Essential Roles During Oocyte Meiotic Spindle Formation and Early Embryonic Development in Sheep. Front Cell Dev Biol. 2021 Feb 25;9:609311. doi:10.3389/fcell.2021.609311. eCollection 2021.

kinesin recruitment by adapter SKIP on melanosomes is dynamically controlled by LC3B phosphorylation

Authors:
Subramaniam Y, Murthy D, Raja DA, Ramkumar A, Sivasubbu S, McEwan DG, Gokhale RS, Natarajan VT
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.434917
Abstract:
Anterograde melanosome transport is essential for adaptive skin tanning response. However, the molecular components involved,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Subramaniam Y, Murthy D, Raja DA, Ramkumar A, Sivasubbu S, McEwan DG, Gokhale RS, Natarajan VT. kinesin recruitment by adapter SKIP on melanosomes is dynamically controlled by LC3B phosphorylation. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.434917.

Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling

Authors:
Xiao Y, Hoodless LJ, Petrucco L, Portugues R, Czopka T
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.434829
Abstract:
Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xiao Y, Hoodless LJ, Petrucco L, Portugues R, Czopka T. Oligodendrocyte Precursor Cells Sculpt the Visual System by Regulating Axonal Remodeling. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.11.434829.

miR-31 promotes neural stem cell proliferation and restores motor function after spinal cord injury

Authors:
Li X, Gao Y, Tian F, Du R, Yuan Y, Li P, Liu F, Wang C
Citation:
Exp Biol Med (Maywood). 2021 Mar 9:1535370221997071. doi: 10.1177/1535370221997071. Online ahead of print
Abstract:
This study aims to examine whether miR-31 promotes endogenous NSC proliferation and be used for spinal cord injury management....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li X, Gao Y, Tian F, Du R, Yuan Y, Li P, Liu F, Wang C. miR-31 promotes neural stem cell proliferation and restores motor function after spinal cord injury. Exp Biol Med (Maywood). 2021 Mar 9:1535370221997071. doi: 10.1177/1535370221997071. Online ahead of print.

Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury

Authors:
Goldman D, Sahu A, Devi S, Jui J
Citation:
bioRxiv. 2021;[preprint] doi:/10.1101/2021.03.11.435053
Abstract:
Unlike mammals, zebrafish can regenerate a damaged retina. Key to this regenerative response are Müller glia (MG) that divide...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Goldman D, Sahu A, Devi S, Jui J. Notch signaling via Hey1 and Id2b regulates Müller glia's regenerative response to retinal injury. bioRxiv. 2021;[preprint] doi:/10.1101/2021.03.11.435053.

Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson–Gilford progeria syndrome

Authors:
Puttaraju M, Jackson M, Klein S, Shilo A, Bennett CF, Gordon L, Rigo F, Misteli T
Citation:
Nat Med. 2021;[Epub ahead of print] doi:10.1038/s41591-021-01262-4
Abstract:
Hutchinson–Gilford progeria syndrome (HGPS) is a rare, invariably fatal childhood premature aging disorder caused by a pre-...
Delivery Method:
i.v. injection
Organism or Cell Type:
mice
Citation Extract:
Puttaraju M, Jackson M, Klein S, Shilo A, Bennett CF, Gordon L, Rigo F, Misteli T. Systematic screening identifies therapeutic antisense oligonucleotides for Hutchinson–Gilford progeria syndrome. Nat Med. 2021;[Epub ahead of print] doi:10.1038/s41591-021-01262-4.

A targeted antisense therapeutic approach for Hutchinson–Gilford progeria syndrome

Authors:
Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS
Citation:
Nat Med. 2021;[Epub ahead of print] doi:10.1038/s41591-021-01274-0
Abstract:
Hutchinson–Gilford progeria syndrome (HGPS) is a rare accelerated aging disorder characterized by premature death from...
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: human progeric fibroblasts, mice
Citation Extract:
Erdos MR, Cabral WA, Tavarez UL, Cao K, Gvozdenovic-Jeremic J, Narisu N, Zerfas PM, Crumley S, Boku Y, Hanson G, Mourich DV, Kole R, Eckhaus MA, Gordon LB, Collins FS. A targeted antisense therapeutic approach for Hutchinson–Gilford progeria syndrome. Nat Med. 2021;[Epub ahead of print] doi:10.1038/s41591-021-01274-0.

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