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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12402 scientific papers returned from the database with the search filters currently being used below.

Mitochondrial dysfunction is driven by imbalanced fission and fusion of mitochondria in myofibrillar myopathy type 5

Authors:
Wu W, Lv X, Feng Y, Yang M, Yang G, Zhao D, Yan C, Lin P
Citation:
Hum Mol Genet. 2025 Apr 17:ddaf051. doi: 10.1093/hmg/ddaf051. Epub ahead of print. PMID: 40244302
Epub:
Not Epub
Abstract:
Myofibrillar myopathy type 5 (MFM5) is a dominantly inherited myopathy caused by mutations in the FLNC gene. The underlying...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu W, Lv X, Feng Y, Yang M, Yang G, Zhao D, Yan C, Lin P. Mitochondrial dysfunction is driven by imbalanced fission and fusion of mitochondria in myofibrillar myopathy type 5. Hum Mol Genet. 2025 Apr 17:ddaf051. doi: 10.1093/hmg/ddaf051. Epub ahead of print. PMID: 40244302.

Solute carrier family 2 member 2 (glucose transporter 2): a common factor of hepatocyte and hepatocellular carcinoma differentiation

Authors:
Kim Y, Yeuni Y, Heo HJ, Kim ES, Myung K, Baryawno N, Kim YH, Oh CK
Citation:
PLoS One. 2025 Apr 25;20(4):e0321020. doi: 10.1371/journal.pone.0321020. PMID: 40279337; PMCID: PMC12026939
Epub:
Not Epub
Abstract:
GLUT2 (SLC2A2), a vital glucose transporter in liver, pancreas, and kidney tissues, regulates blood glucose levels and energy...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kim Y, Yeuni Y, Heo HJ, Kim ES, Myung K, Baryawno N, Kim YH, Oh CK. Solute carrier family 2 member 2 (glucose transporter 2): a common factor of hepatocyte and hepatocellular carcinoma differentiation. PLoS One. 2025 Apr 25;20(4):e0321020. doi: 10.1371/journal.pone.0321020. PMID: 40279337; PMCID: PMC12026939.

The Rho GEF Trio functions in contact inhibition of locomotion of neural crest cells by interacting with Ptk7

Authors:
Till K, Borchers A
Citation:
Development. 2025 May 1;152(9):dev204446. doi: 10.1242/dev.204446. Epub 2025 May 6. PMID: 40326503
Epub:
Not Epub
Abstract:
Neural crest (NC) cells are highly migratory cells that contribute to a wide range of vertebrate tissues and must respond to a...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Till K, Borchers A. The Rho GEF Trio functions in contact inhibition of locomotion of neural crest cells by interacting with Ptk7. Development. 2025 May 1;152(9):dev204446. doi: 10.1242/dev.204446. Epub 2025 May 6. PMID: 40326503.

Timely neurogenesis drives the transition from nematic to crystalline nuclear packing during retinal morphogenesis

Authors:
Ferme LC, Ryan AQ, Haase R, Modes CD, Norden C
Citation:
Sci Adv. 2025 May 9;11(19):eadu6843. doi: 10.1126/sciadv.adu6843. Epub 2025 May 9. PMID: 40344072; PMCID: PMC12063663
Epub:
Not Epub
Abstract:
Correct organogenesis depends on the timely coordination of developmental processes, such as cell proliferation,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ferme LC, Ryan AQ, Haase R, Modes CD, Norden C. Timely neurogenesis drives the transition from nematic to crystalline nuclear packing during retinal morphogenesis. Sci Adv. 2025 May 9;11(19):eadu6843. doi: 10.1126/sciadv.adu6843. Epub 2025 May 9. PMID: 40344072; PMCID: PMC12063663.

CITK modulates BRCA1 recruitment at DNA double strand breaks sites through HDAC6

Authors:
Iegiani G, Pallavicini G, Pezzotta A, Brix A, Ferraro A, Gai M, Boda E, Bielas SL, Pistocchi A, Di Cunto F
Citation:
Cell Death Dis. 2025 Apr 20;16(1):320. doi: 10.1038/s41419-025-07655-4. PMID: 40254670; PMCID: PMC12009987
Epub:
Not Epub
Abstract:
Citron Kinase (CITK) is a protein encoded by the CIT gene, whose pathogenic variants underlie microcephalic phenotypes that...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Iegiani G, Pallavicini G, Pezzotta A, Brix A, Ferraro A, Gai M, Boda E, Bielas SL, Pistocchi A, Di Cunto F. CITK modulates BRCA1 recruitment at DNA double strand breaks sites through HDAC6. Cell Death Dis. 2025 Apr 20;16(1):320. doi: 10.1038/s41419-025-07655-4. PMID: 40254670; PMCID: PMC12009987.

Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration

Authors:
Xu J, Li Y, Li X, Tan X, Liu L, Cao L, Xu H
Citation:
Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):67. doi: 10.1167/iovs.66.4.67. PMID: 40266594; PMCID: PMC12025339
Epub:
Not Epub
Abstract:
Purpose: Inflammation activates the Jak1-Stat3 signaling pathway in zebrafish Müller glia (MG), leading to their status...
Delivery Method:
intravitreal injection & electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Xu J, Li Y, Li X, Tan X, Liu L, Cao L, Xu H. Microglia-Derived IL-6 Promotes Müller Glia Reprogramming and Proliferation in Zebrafish Retina Regeneration. Invest Ophthalmol Vis Sci. 2025 Apr 1;66(4):67. doi: 10.1167/iovs.66.4.67. PMID: 40266594; PMCID: PMC12025339.

Role of different Lyl1 transcripts in zebrafish primitive hematopoiesis

Authors:
Lin JH, Yang TS, Zhang WQ, Liu W
Citation:
Yi Chuan. 2025 May;47(5):573-588. doi: 10.16288/j.yczz.24-288. PMID: 40287790
Epub:
Not Epub
Abstract:
Primitive hematopoiesis is a crucial process in the organism, responsible for the transportation of oxygen and nutrients during...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin JH, Yang TS, Zhang WQ, Liu W. Role of different Lyl1 transcripts in zebrafish primitive hematopoiesis. Yi Chuan. 2025 May;47(5):573-588. doi: 10.16288/j.yczz.24-288. PMID: 40287790.

Two-component T-cell immunotherapy enables antigen pre-targeting to reduce cytokine release without forfeiting efficacy

Authors:
Gambles MT, Kendell I, Li J, Spainhower K, Sborov D, Owen S, Stark A, Bearss D, Yang J, Kopeček J
Citation:
Nanomedicine. 2025 Apr 30;67:102825. doi: 10.1016/j.nano.2025.102825. Epub ahead of print. PMID: 40316226
Epub:
Not Epub
Abstract:
Contemporary T-cell immunotherapies, despite impressive targeting precision, are hindered by aberrant cytokine release and...
Delivery Method:
Fab-linked; mice: intravenous (i.v.) injection
Organism or Cell Type:
cell culture: Raji B-cells; mice: SCID C·B-17
Citation Extract:
Gambles MT, Kendell I, Li J, Spainhower K, Sborov D, Owen S, Stark A, Bearss D, Yang J, Kopeček J. Two-component T-cell immunotherapy enables antigen pre-targeting to reduce cytokine release without forfeiting efficacy. Nanomedicine. 2025 Apr 30;67:102825. doi: 10.1016/j.nano.2025.102825. Epub ahead of print. PMID: 40316226.

G protein-coupled receptor GPR182 negatively regulates sprouting angiogenesis via modulating CXCL12-CXCR4 axis signaling

Authors:
Chen C, Liu W, Yuan F, Wang X, Xu X, Ling CC, Ge X, Shen X, Li B, Shen Y, Liu D
Citation:
Angiogenesis. 2025 May 2;28(3):25. doi: 10.1007/s10456-025-09977-5. PMID: 40314798; PMCID: PMC12048421
Epub:
Not Epub
Abstract:
Angiogenesis is a critical process for tumor progression, regulated by various signaling pathways. Although antiangiogenic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen C, Liu W, Yuan F, Wang X, Xu X, Ling CC, Ge X, Shen X, Li B, Shen Y, Liu D. G protein-coupled receptor GPR182 negatively regulates sprouting angiogenesis via modulating CXCL12-CXCR4 axis signaling. Angiogenesis. 2025 May 2;28(3):25. doi: 10.1007/s10456-025-09977-5. PMID: 40314798; PMCID: PMC12048421.

Loss of cep57 function induces G1 arrest and microcephaly

Authors:
Iyer S, Gokhale A, Shree Murugesan P, Kumar M
Citation:
bioRxiv [preprint] 2025.04.10.648303; doi: https://doi.org/10.1101/2025.04.10.648303
Epub:
Not Epub
Abstract:
Centrosomal protein 57 (CEP57) is essential for centrosome organization, regulating nucleation and stabilization of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Iyer S, Gokhale A, Shree Murugesan P, Kumar M. Loss of cep57 function induces G1 arrest and microcephaly. bioRxiv [preprint] 2025.04.10.648303; doi: https://doi.org/10.1101/2025.04.10.648303.

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