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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12511 scientific papers returned from the database with the search filters currently being used below.

Guanidinium-linked morpholino-siRNA chimera: synthesis, biophysical properties and in vitro activity

Authors:
Gupta S, Ghosh A, Pratihar S, Mukherjee M, Kundu J, Sinha S
Citation:
Chem Commun (Camb). 2025 Aug 22. doi: 10.1039/d5cc03543k. Epub ahead of print. PMID: 40842421
Epub:
Not Epub
Abstract:
This study introduces guanidinium morpholino RNA (GMO-RNA), an RNA analogue with enhanced cell permeability, nuclease...
Link:
https://pubs.rsc.org/en/content/articlelanding/2025/cc/d5cc03543k
Organism or Cell Type:
cell culture: PC-3, DU 145, MDA-MB-231, MCF7, HepG2
Citation Extract:
Gupta S, Ghosh A, Pratihar S, Mukherjee M, Kundu J, Sinha S. Guanidinium-linked morpholino-siRNA chimera: synthesis, biophysical properties and in vitro activity. Chem Commun (Camb). 2025 Aug 22. doi: 10.1039/d5cc03543k. Epub ahead of print. PMID: 40842421.

A combinatorial oligonucleotide therapy to improve dystrophin restoration and dystrophin-deficient muscle health

Authors:
Moon YJ, Hindupur R, Gamu IH, McCormack NM, Shaikh F, Novak JS, Jaiswal JK
Citation:
Mol Ther Nucleic Acids. 2025 Aug 5;36(3):102665. doi: 10.1016/j.omtn.2025.102665. PMID: 40896584; PMCID: PMC12398789
Epub:
Not Epub
Abstract:
Despite the proven safety of dystrophin-targeting phosphorodiamidate morpholino oligomer (PMO) therapy, poor delivery of the...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(25)00219-7
Delivery Method:
intramuscular (i.m.) in the TA or intravenous (i.v.) in the retro-orbital sinus
Organism or Cell Type:
mdx mice
Citation Extract:
Moon YJ, Hindupur R, Gamu IH, McCormack NM, Shaikh F, Novak JS, Jaiswal JK. A combinatorial oligonucleotide therapy to improve dystrophin restoration and dystrophin-deficient muscle health. Mol Ther Nucleic Acids. 2025 Aug 5;36(3):102665. doi: 10.1016/j.omtn.2025.102665. PMID: 40896584; PMCID: PMC12398789.

A functional surface display system in Saccharomyces boulardii for protein absorption in simulated intestinal fluids

Authors:
Waldrip ZJ, Burdine L, Peterson EC, Rainwater RR, Min Y, Burdine MS
Citation:
iScience preprint (2025), doi: https://doi.org/10.1016/j.isci.2025.113303
Epub:
Not Epub
Abstract:
There is untapped potential for medical breakthroughs using engineered microbes to treat conditions such as those of the...
Link:
https://www.cell.com/iscience/pdf/S2589-0042(25)01564-0.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Waldrip ZJ, Burdine L, Peterson EC, Rainwater RR, Min Y, Burdine MS. A functional surface display system in Saccharomyces boulardii for protein absorption in simulated intestinal fluids. iScience preprint (2025), doi: https://doi.org/10.1016/j.isci.2025.113303.

A 3D genome compendium of breast cancer progression

Authors:
den Brand T, Collier MD, Flach KD, Gregoricchio S, Mayayo-Peralta I, Dauyey Z, Schuurman K, Teunissen H, Zwart W, de Wit E
Citation:
iScience (2025), doi: https://doi.org/10.1016/j.isci.2025.113268
Epub:
Not Epub
Abstract:
During cancer development and progression massive alterations in gene expression are observed. Gene regulation occurs within...
Link:
https://www.cell.com/iscience/pdf/S2589-0042(25)01529-9.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
den Brand T, Collier MD, Flach KD, Gregoricchio S, Mayayo-Peralta I, Dauyey Z, Schuurman K, Teunissen H, Zwart W, de Wit E. A 3D genome compendium of breast cancer progression. iScience (2025), doi: https://doi.org/10.1016/j.isci.2025.113268.

Novel autosomal dominant syndromic hearing loss caused by COL4A2 -related basement membrane dysfunction of cochlear capillaries and microcirculation disturbance

Authors:
Yang J, Ma Y, Gao X, Qiu S, Li X, Zhao W, Chen Y, Dong G, Lin R, Wei G, Nie H, Feng H, Gu X, Gao B, Dai P, Yuan Y
Citation:
Chin Med J (Engl). 2025 Aug 5;138(15):1888-1890. doi: 10.1097/CM9.0000000000003600. Epub 2025 Jul 9. PMID: 40629513; PMCID: PMC12321472
Epub:
Not Epub
Link:
https://journals.lww.com/cmj/fulltext/2025/08050/novel_autosomal_dominant_syndromic_hearing_loss.13.aspx
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang J, Ma Y, Gao X, Qiu S, Li X, Zhao W, Chen Y, Dong G, Lin R, Wei G, Nie H, Feng H, Gu X, Gao B, Dai P, Yuan Y. Novel autosomal dominant syndromic hearing loss caused by COL4A2 -related basement membrane dysfunction of cochlear capillaries and microcirculation disturbance. Chin Med J (Engl). 2025 Aug 5;138(15):1888-1890. doi: 10.1097/CM9.0000000000003600. Epub 2025 Jul 9. PMID: 40629513; PMCID: PMC12321472.

Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles

Authors:
Chrisman AN, Sugimoto C, Butler-Struben H, Minie VA, Anderson D, Eagle AL, Duque-Wilckens N, Ramos A, Lewis YI, Archdeacon SC, Robison AJ, Trainor BC
Citation:
bioRxiv [Preprint]. 2025 Aug 3:2025.08.03.668226. doi: 10.1101/2025.08.03.668226. PMID: 40766368; PMCID: PMC12324468
Epub:
Not Epub
Abstract:
Oxytocin is a neuropeptide that can either promote or inhibit affiliative social behaviors. Recent evidence suggests that these...
Link:
https://www.biorxiv.org/content/10.1101/2025.08.03.668226v1
Delivery Method:
paraventricular nucleus injection
Organism or Cell Type:
Peromyscus californicus (California mice)
Citation Extract:
Chrisman AN, Sugimoto C, Butler-Struben H, Minie VA, Anderson D, Eagle AL, Duque-Wilckens N, Ramos A, Lewis YI, Archdeacon SC, Robison AJ, Trainor BC. Oxytocin neurons in the anterior and posterior paraventricular nucleus have distinct behavioral functions and electrophysiological profiles. bioRxiv [Preprint]. 2025 Aug 3:2025.08.03.668226. doi: 10.1101/2025.08.03.668226. PMID: 40766368; PMCID: PMC12324468.

circANKRD12/circTIMMDC1 synergistically regulates enteric neural crest cell migration via miR-181b-5p-PROX1-NOTCH1 axis in Hirschsprung's disease

Authors:
Fu R, Wang C, Xu Z, Zhai J, Zhao Y, Liu X, Zhou Y, Gu P, Pan W, Wang Y, Cai W
Citation:
Pediatr Res. 2025 Aug 1. doi: 10.1038/s41390-025-04245-0. Epub ahead of print. PMID: 40750918
Epub:
Not Epub
Abstract:
Background: Circular RNAs (circRNAs) are implicated in Hirschsprung's disease (HSCR), a genetic disorder caused by...
Link:
https://www.nature.com/articles/s41390-025-04245-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fu R, Wang C, Xu Z, Zhai J, Zhao Y, Liu X, Zhou Y, Gu P, Pan W, Wang Y, Cai W. circANKRD12/circTIMMDC1 synergistically regulates enteric neural crest cell migration via miR-181b-5p-PROX1-NOTCH1 axis in Hirschsprung's disease. Pediatr Res. 2025 Aug 1. doi: 10.1038/s41390-025-04245-0. Epub ahead of print. PMID: 40750918.

SRC kinase isoforms regulate mRNA splicing during neural development

Authors:
Pizzey AR, West LC, Elberfeld SJ, Lewis PA, Walker H, Cowell L, Newling K, Dowle A, Evans GJO, Isaacs HV
Citation:
J Neurosci. 2025 Aug 1:e1705242025. doi: 10.1523/JNEUROSCI.1705-24.2025. Epub ahead of print. PMID: 40750357
Epub:
Not Epub
Abstract:
Alternative mRNA splicing generates transcriptomic diversity to direct tissue-specific functions. There is a high level of...
Link:
https://www.jneurosci.org/content/early/2025/07/31/JNEUROSCI.1705-24.2025.long
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Pizzey AR, West LC, Elberfeld SJ, Lewis PA, Walker H, Cowell L, Newling K, Dowle A, Evans GJO, Isaacs HV. SRC kinase isoforms regulate mRNA splicing during neural development. J Neurosci. 2025 Aug 1:e1705242025. doi: 10.1523/JNEUROSCI.1705-24.2025. Epub ahead of print. PMID: 40750357.

TMBIM4 affects left-right patterning via pluripotency exit during gastrulation

Authors:
Diab NS, Kostiuk V, Tyan L, Mis E, Zenisek D, Khokha MK
Citation:
Dev Biol. 2025 Jul 29:S0012-1606(25)00209-X. doi: 10.1016/j.ydbio.2025.07.018. Epub ahead of print. PMID: 40744297
Epub:
Not Epub
Abstract:
Congenital heart disease (CHD) is the most prevalent congenital defect, but its underlying genetic and developmental mechanisms...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S001216062500209X
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Diab NS, Kostiuk V, Tyan L, Mis E, Zenisek D, Khokha MK. TMBIM4 affects left-right patterning via pluripotency exit during gastrulation. Dev Biol. 2025 Jul 29:S0012-1606(25)00209-X. doi: 10.1016/j.ydbio.2025.07.018. Epub ahead of print. PMID: 40744297.

A novel function for Prdm12 during neural crest migration reveals a link between Wnt and N-cadherin

Authors:
Seal S, Milet C, Zhou C, Monsoro-Burq A-H
Citation:
bioRxiv [preprint] 2025.07.28.667246; doi: https://doi.org/10.1101/2025.07.28.667246
Epub:
Not Epub
Abstract:
The delamination of neural crest cells is a critical developmental event shaping the vertebrate head and peripheral nervous...
Link:
https://www.biorxiv.org/content/10.1101/2025.07.28.667246v1.full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Seal S, Milet C, Zhou C, Monsoro-Burq A-H. A novel function for Prdm12 during neural crest migration reveals a link between Wnt and N-cadherin. bioRxiv [preprint] 2025.07.28.667246; doi: https://doi.org/10.1101/2025.07.28.667246.

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