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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10704 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Knockdown of hspg2 is associated with abnormal mandibular joint formation and neural crest cell dysfunction in zebrafish

Authors:
Castellanos BS, Reyes-Nava NG, Quintana AM
Citation:
BMC Dev Biol. 2021 Mar 8;21(1):7. doi: 10.1186/s12861-021-00238-4
Abstract:
Background: Heparan sulfate proteoglycan 2 (HSPG2) encodes for perlecan, a large proteoglycan that plays an important role in...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Castellanos BS, Reyes-Nava NG, Quintana AM. Knockdown of hspg2 is associated with abnormal mandibular joint formation and neural crest cell dysfunction in zebrafish. BMC Dev Biol. 2021 Mar 8;21(1):7. doi: 10.1186/s12861-021-00238-4.

Na+/H+-exchangers differentially contribute to midgut fluid sodium and proton concentration in the sea urchin larva

Authors:
Petersen I, Chang WWJ, Hu MY
Citation:
J Exp Biol. 2021;jeb.240705 doi: 10.1242/jeb.240705 Published 5 March 2021
Abstract:
Regulation of ionic composition and pH is a requisite of all digestive systems in the animal kingdom. Larval stages of the...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Petersen I, Chang WWJ, Hu MY. Na+/H+-exchangers differentially contribute to midgut fluid sodium and proton concentration in the sea urchin larva. J Exp Biol. 2021;jeb.240705 doi: 10.1242/jeb.240705 Published 5 March 2021.

Antiviral Activity of a New Class of Chemically Modified Antisense Oligonucleotides against Influenza А Virus

Authors:
Markov AV, Kupryushkin MS, Goncharova EP, Amirkhanov RN, Vasilyeva SV, Pyshnyi DV, Zenkova MA, Logashenko EB
Citation:
Russ J Bioorg Chem. 2019;45(6):774-782. doi:10.1134/S1068162019060268
Abstract:
The paper reports the synthesis of a series of antisense oligonucleotides (aONs) directed against different segments of the...
Delivery Method:
Endo-Porter, scrape delivery
Organism or Cell Type:
cell culture: (H1N1)/MDCK, (H1N1)/A549 influenza in cells
Citation Extract:
Markov AV, Kupryushkin MS, Goncharova EP, Amirkhanov RN, Vasilyeva SV, Pyshnyi DV, Zenkova MA, Logashenko EB. Antiviral Activity of a New Class of Chemically Modified Antisense Oligonucleotides against Influenza А Virus. Russ J Bioorg Chem. 2019;45(6):774-782. doi:10.1134/S1068162019060268.

Human-specific staphylococcal virulence factors enhance pathogenicity in a humanised zebrafish C5a receptor model

Authors:
Buchan KD, van Gent M, Prajsnar TK, Ogryzko NV, de Jong NWM, Kolata J, Foster SJ, van Strijp JAG, Renshaw SA
Citation:
J Cell Sci. 2021;134:jcs252205 doi:10.1242/jcs.252205
Abstract:
Staphylococcus aureus infects ∼30% of the human population and causes a spectrum of pathologies ranging from mild skin...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Buchan KD, van Gent M, Prajsnar TK, Ogryzko NV, de Jong NWM, Kolata J, Foster SJ, van Strijp JAG, Renshaw SA. Human-specific staphylococcal virulence factors enhance pathogenicity in a humanised zebrafish C5a receptor model. J Cell Sci. 2021;134:jcs252205 doi:10.1242/jcs.252205.

Novel Dioxane and Morpholino Nucleotide Analogues: Syntheses and RNA-Hybridization Properties

Authors:
Hofmeister A, Jahn-Hofmann K, Krack A, Müller A, Kurz M, Scheidler S
Citation:
Chembiochem. 2020 Oct 28. doi: 10.1002/cbic.202000693
Abstract:
A novel class of nucleotide analogues with a dioxane ring as central scaffold has been developed. Synthetic routes in two...
Citation Extract:
Hofmeister A, Jahn-Hofmann K, Krack A, Müller A, Kurz M, Scheidler S. Novel Dioxane and Morpholino Nucleotide Analogues: Syntheses and RNA-Hybridization Properties. Chembiochem. 2020 Oct 28. doi: 10.1002/cbic.202000693.

Jagged–Notch-mediated divergence of immune cell crosstalk maintains the anti-inflammatory response in visceral leishmaniasis

Authors:
Chandrakar P, Seth A, Rani A, Dutta M, Parmar N, Descoteaux A, Kar S
Citation:
J Cell Sci. 2021;134:jcs252494 doi:10.1242/jcs.252494
Abstract:
Notch signaling governs crucial aspects of intercellular communication spanning antigen-presenting cells and T-cells. In this...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Balb/c mice and sometimes Leishmania donovani infections
Citation Extract:
Chandrakar P, Seth A, Rani A, Dutta M, Parmar N, Descoteaux A, Kar S. Jagged–Notch-mediated divergence of immune cell crosstalk maintains the anti-inflammatory response in visceral leishmaniasis. J Cell Sci. 2021;134:jcs252494 doi:10.1242/jcs.252494 .

Transglutaminase Type 2 regulates the Wnt/β-catenin pathway in vertebrates

Authors:
Rossin F, Costa R, Bordi M, D’Eletto M, Occhigrossi L, Farrace MG, Barlev N, Ciccosanti F, Muccioli S, Chieregato L, Szabo I, Fimia GM, Piacentini M, Leanza L
Citation:
Cell Death Dis. 2021;12(3):249. doi:10.1038/s41419-021-03485-2
Abstract:
TG2 is a multifunctional enzyme involved in several cellular processes and has emerging as a potential regulator of gene...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rossin F, Costa R, Bordi M, D’Eletto M, Occhigrossi L, Farrace MG, Barlev N, Ciccosanti F, Muccioli S, Chieregato L, Szabo I, Fimia GM, Piacentini M, Leanza L. Transglutaminase Type 2 regulates the Wnt/β-catenin pathway in vertebrates. Cell Death Dis. 2021;12(3):249. doi:10.1038/s41419-021-03485-2.

Adherens junctions are involved in polarized contractile ring formation in dividing epithelial cells of Xenopus laevis embryos

Authors:
Hatte G, Prigent C, Tassan J-P
Citation:
Exp Cell Res. 2021:112525. doi:10.1016/j.yexcr.2021.112525
Abstract:
Cells dividing in the plane of epithelial tissues proceed by polarized constriction of the actomyosin contractile ring, leading...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Hatte G, Prigent C, Tassan J-P. Adherens junctions are involved in polarized contractile ring formation in dividing epithelial cells of Xenopus laevis embryos. Exp Cell Res. 2021:112525. doi:10.1016/j.yexcr.2021.112525.

Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation

Authors:
Dastpeyman M, Karas JA, Amin A, Turner BJ, Shabanpoor F
Citation:
Front Chem. 2021;9:9. doi:10.3389/fchem.2021.627329
Abstract:
Cell penetrating peptides (CPPs) are being increasingly used as efficient vectors for intracellular delivery of biologically...
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: spinal muscular atrophy (SMA) patient fibroblasts
Citation Extract:
Dastpeyman M, Karas JA, Amin A, Turner BJ, Shabanpoor F. Modular Synthesis of Trifunctional Peptide-oligonucleotide Conjugates via Native Chemical Ligation. Front Chem. 2021;9:9. doi:10.3389/fchem.2021.627329.

hnRNP L is essential for myogenic differentiation and modulates myotonic dystrophy pathologies

Authors:
Alexander MS, Hightower RM, Reid AL, Bennett AH, Iyer L, Slonim DK, Saha M, Kawahara G, Kunkel LM, Kopin AS, Gupta VA, Kang PB, Draper I
Citation:
Muscle Nerve. 2021 Mar 2. doi: 10.1002/mus.27216. Online ahead of print
Abstract:
Introduction/aims: RNA binding proteins (RBPs) play an important role in skeletal muscle development and disease by regulating...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Alexander MS, Hightower RM, Reid AL, Bennett AH, Iyer L, Slonim DK, Saha M, Kawahara G, Kunkel LM, Kopin AS, Gupta VA, Kang PB, Draper I. hnRNP L is essential for myogenic differentiation and modulates myotonic dystrophy pathologies. Muscle Nerve. 2021 Mar 2. doi: 10.1002/mus.27216. Online ahead of print.

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