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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9947 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis

Authors:
Sie Z-L, Li R-Y, Sampurna PB, Hsu P-J, Liu S-C, Wang H-D, Huang C-L, Yuh C-H
Citation:
Cancers. 2020;12(3):[Epub] doi:0.3390/cancers12030575
Abstract:
With-no-lysine (K)-1 (WNK1) is the founding member of family of four protein kinases with atypical placement of catalytic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sie Z-L, Li R-Y, Sampurna PB, Hsu P-J, Liu S-C, Wang H-D, Huang C-L, Yuh C-H. WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis. Cancers. 2020;12(3):[Epub] doi:0.3390/cancers12030575.

Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy

Authors:
Misra C, Bangru S, Lin F, Lam K, Koenig SN, Lubbers ER, Hedhli J, Murphy NP, Parker DJ, Dobrucki LW, Cooper TA, Tajkhorshid E, Mohler PJ, Kalsotra A
Citation:
Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.01.037
Abstract:
Myotonic dystrophy type 1 (DM1) is a multisystemic genetic disorder caused by the CTG repeat expansion in the 3′-untranslated...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HL-1
Citation Extract:
Misra C, Bangru S, Lin F, Lam K, Koenig SN, Lubbers ER, Hedhli J, Murphy NP, Parker DJ, Dobrucki LW, Cooper TA, Tajkhorshid E, Mohler PJ, Kalsotra A. Aberrant Expression of a Non-muscle RBFOX2 Isoform Triggers Cardiac Conduction Defects in Myotonic Dystrophy. Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.01.037.

Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo

Authors:
Floc'hlay S, Jimenez MDM, Hernandez C, Haillot E, Thomas-Chollier M, Lepage T, Thieffry D
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.02.26.966556
Abstract:
During sea urchin development, secretion of Nodal and BMP2/4 ligands and their antagonists Lefty and Chordin from a ventral...
Delivery Method:
microinjection
Organism or Cell Type:
Paracentrotus lividus (sea urchin)
Citation Extract:
Floc'hlay S, Jimenez MDM, Hernandez C, Haillot E, Thomas-Chollier M, Lepage T, Thieffry D. Deciphering and modelling the TGF-β signalling interplays specifying the dorsal-ventral axis of the sea urchin embryo. bioRxiv. 2020;[preprint] doi:10.1101/2020.02.26.966556.

Wip1 regulates Smad4 phosphorylation and inhibits TGF‐β signaling

Authors:
Park D-S, Yoon G-H, Kim E-Y, Lee T, Kim K, Lee PCW, Chang E-J, Choi S-C
Citation:
EMBO Rep. 2020;[Epub] doi:10.15252/embr.201948693
Abstract:
The tumor suppressor Smad4, a key mediator of the TGF‐β/BMP pathways, is essential for development and tissue homeostasis....
Organism or Cell Type:
Xenopus
Citation Extract:
Park D-S, Yoon G-H, Kim E-Y, Lee T, Kim K, Lee PCW, Chang E-J, Choi S-C. Wip1 regulates Smad4 phosphorylation and inhibits TGF‐β signaling. EMBO Rep. 2020;[Epub] doi:10.15252/embr.201948693.

Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model

Authors:
Sheng L, Rigo F, Bennett CF, Krainer AR, Hua Y
Citation:
Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa126
Abstract:
Spinal muscular atrophy (SMA) is a motor neuron disease. Nusinersen, a splice-switching antisense oligonucleotide (ASO), was...
Delivery Method:
subcutaneous (s.c.) injection
Organism or Cell Type:
mice
Citation Extract:
Sheng L, Rigo F, Bennett CF, Krainer AR, Hua Y. Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model. Nucl Acids Res. 2020;[Epub ahead of print] doi:10.1093/nar/gkaa126.

pmar1/phb homeobox genes and the evolution of the double-negative gate for endomesoderm specification in echinoderms

Authors:
Yamazaki A, Morino Y, Urata M, Yamaguchi M, Minokawa T, Furukawa R, Kondo M, Wada H
Citation:
Development. 2020;147:[Epub ahead of print] doi:10.1242/dev.182139
Abstract:
In several model animals, the earliest phases of embryogenesis are regulated by lineage-specific genes, such as Drosophila...
Delivery Method:
microinjection
Organism or Cell Type:
Patria pectinifera (sea star)
Citation Extract:
Yamazaki A, Morino Y, Urata M, Yamaguchi M, Minokawa T, Furukawa R, Kondo M, Wada H. pmar1/phb homeobox genes and the evolution of the double-negative gate for endomesoderm specification in echinoderms. Development. 2020;147:[Epub ahead of print] doi:10.1242/dev.182139.

Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation

Authors:
Cisterna BA, Vargas AA, Puebla C, Fernández P, Escamilla R, Lagos CF, Matus MF, Vilos C, Cea LA, Barnafi E, Gaete H, Escobar DF, Cardozo CP, Sáez JC
Citation:
Nat Commun. 2020;11:1073 doi:s41467-019-14063-8
Abstract:
Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by cellular alterations such as increased...
Delivery Method:
lipofectamine 2000
Organism or Cell Type:
cell culture: myofibrils
Citation Extract:
Cisterna BA, Vargas AA, Puebla C, Fernández P, Escamilla R, Lagos CF, Matus MF, Vilos C, Cea LA, Barnafi E, Gaete H, Escobar DF, Cardozo CP, Sáez JC. Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation. Nat Commun. 2020;11:1073 doi:s41467-019-14063-8.

Histone variant dictates fate biasing of neural crest cells to melanocyte lineage

Authors:
Raja DA, Subramaniam Y, Aggarwal A, Gotherwal V, Babu A, Tanwar J, Motiani RK, Sivasubbu S, Gokhale RS, Natarajan VT
Citation:
Development. 2020;[Epub ahead of print] doi:10.1242/dev.182576
Abstract:
In the neural crest lineage, progressive fate-restriction and stem cell assignment are critical for both development and...
Organism or Cell Type:
zebrafish
Citation Extract:
Raja DA, Subramaniam Y, Aggarwal A, Gotherwal V, Babu A, Tanwar J, Motiani RK, Sivasubbu S, Gokhale RS, Natarajan VT. Histone variant dictates fate biasing of neural crest cells to melanocyte lineage. Development. 2020;[Epub ahead of print] doi:10.1242/dev.182576.

New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration

Authors:
Pasteuning-Vuhman S, Boertje-van der Meulen JW, Putten MV, Overzier M, Ten Dijke P, Kielbasa SM, Arindrarto W, Wolterbeek R, Lezhnina KV, Ozerov IV, Aliper AM, Hoogaars WM, Aartsma-Rus A, Loomans CJM
Citation:
FASEB J. 2017 Jan;31(1):238-255. doi: 10.1096/fj.201600675r
Abstract:
Skeletal muscle fibrosis and impaired muscle regeneration are major contributors to muscle wasting in Duchenne muscular...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: C2C12 myoblasts, 4-wk-old male mdx or 3-mo-old male C57BL/6Jico WT mice
Citation Extract:
Pasteuning-Vuhman S, Boertje-van der Meulen JW, Putten MV, Overzier M, Ten Dijke P, Kielbasa SM, Arindrarto W, Wolterbeek R, Lezhnina KV, Ozerov IV, Aliper AM, Hoogaars WM, Aartsma-Rus A, Loomans CJM. New function of the myostatin/activin type I receptor (ALK4) as a mediator of muscle atrophy and muscle regeneration. FASEB J. 2017 Jan;31(1):238-255. doi: 10.1096/fj.201600675r.

Wnt5b integrates Fak1a to mediate gastrulation cell movements via Rac1 and Cdc42

Authors:
Hung IC, Chen TM, Lin JP, Tai YL, Shen TL, Lee SJ
Citation:
Open Biol. 2020 Feb;10(2):190273. doi: 10.1098/rsob.190273. Epub 2020 Feb 26
Abstract:
Focal adhesion kinase (FAK) mediates vital cellular pathways during development. Despite its necessity, how FAK regulates and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hung IC, Chen TM, Lin JP, Tai YL, Shen TL, Lee SJ. Wnt5b integrates Fak1a to mediate gastrulation cell movements via Rac1 and Cdc42. Open Biol. 2020 Feb;10(2):190273. doi: 10.1098/rsob.190273. Epub 2020 Feb 26.

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