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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9743 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Oct4 mediates Müller glia reprogramming and cell cycle exit during retina regeneration in zebrafish

Authors:
Sharma P, Gupta S, Chaudhary M, Mitra S, Chawla B, Khursheed MA, Ramachandran R
Citation:
Life Sci Alliance. 2019 Oct 8;2(5). pii: e201900548. doi: 10.26508/lsa.201900548. Print 2019 Oct
Abstract:
Octamer-binding transcription factor 4 (Oct4, also known as Pou5F3) is an essential pluripotency-inducing factor, governing a...
Delivery Method:
ocular injection then electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Sharma P, Gupta S, Chaudhary M, Mitra S, Chawla B, Khursheed MA, Ramachandran R. Oct4 mediates Müller glia reprogramming and cell cycle exit during retina regeneration in zebrafish. Life Sci Alliance. 2019 Oct 8;2(5). pii: e201900548. doi: 10.26508/lsa.201900548. Print 2019 Oct.

Spliceosomal disruption of the non-canonical BAF complex in cancer

Authors:
Inoue D, Chew G-L, Liu B, Michel BC, Pangallo J, D’Avino AR, Hitchman T, North K, Lee SC-W, Bitner L, Block A, Moore AR, Yoshimi A, Escobar-Hoyos L, Cho H, Penson A, Lu SX, Taylor J, Chen Y, Kadoch C, Abdel-Wahab O, Bradley RK
Citation:
Nature. 2019;[Epub ahead of print] doi:10.1038/s41586-019-1646-9
Abstract:
SF3B1 is the most commonly mutated RNA splicing factor in cancer1–4, but the mechanisms by which SF3B1 mutations promote...
Delivery Method:
intratumoral injection
Organism or Cell Type:
cell culture: MEL202 cells (SF3B1R625G) xenografted in mice
Citation Extract:
Inoue D, Chew G-L, Liu B, Michel BC, Pangallo J, D’Avino AR, Hitchman T, North K, Lee SC-W, Bitner L, Block A, Moore AR, Yoshimi A, Escobar-Hoyos L, Cho H, Penson A, Lu SX, Taylor J, Chen Y, Kadoch C, Abdel-Wahab O, Bradley RK. Spliceosomal disruption of the non-canonical BAF complex in cancer. Nature. 2019;[Epub ahead of print] doi:10.1038/s41586-019-1646-9.

Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility

Authors:
Pritchard HAT,Griffin CS, Yamasaki E, Thakore P, Lane C, Greenstein AS, Earley S
Citation:
PNAS USA. 2019 Oct 22;116(43):21874-21881. doi: 10.1073/pnas.1911304116. Epub 2019 Oct 7
Abstract:
Junctophilin proteins maintain close contacts between the endoplasmic/sarcoplasmic reticulum (ER/SR) and the plasma membrane in...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: dissected cerebral arteries (vascular smooth muscle)
Citation Extract:
Pritchard HAT,Griffin CS, Yamasaki E, Thakore P, Lane C, Greenstein AS, Earley S. Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility. PNAS USA. 2019 Oct 22;116(43):21874-21881. doi: 10.1073/pnas.1911304116. Epub 2019 Oct 7.

Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish

Authors:
Mano H, Asaoka Y, Kojima D, Fukada Y
Citation:
Commun Biol. 2019;2(1):364 doi:10.1038/s42003-019-0613-1
Abstract:
The pineal gland functioning as a photoreceptive organ in non-mammalian species is a serial homolog of the retina. Here we...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mano H, Asaoka Y, Kojima D, Fukada Y. Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish. Commun Biol. 2019;2(1):364 doi:10.1038/s42003-019-0613-1.

p63 is a cereblon substrate involved in thalidomide teratogenicity

Authors:
Asatsuma-Okumura T, Ando H, De Simone M, Yamamoto J, Sato T, Shimizu N, Asakawa K, Yamaguchi Y, Ito T, Guerrini L, Handa H
Citation:
Nat Chem Biol. 2019;[Epub ahead of print] doi:10.1038/s41589-019-0366-7
Abstract:
Cereblon (CRBN) is a primary target of thalidomide and mediates its multiple pharmacological activities, including teratogenic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Asatsuma-Okumura T, Ando H, De Simone M, Yamamoto J, Sato T, Shimizu N, Asakawa K, Yamaguchi Y, Ito T, Guerrini L, Handa H. p63 is a cereblon substrate involved in thalidomide teratogenicity. Nat Chem Biol. 2019;[Epub ahead of print] doi:10.1038/s41589-019-0366-7.

Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes

Authors:
Sato M, Shiba N, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, Takizawa H, Aoki Y, Takeda S, Nakamura A
Citation:
Biochem Biophys Res Commun. 2019 Oct 1. pii: S0006-291X(19)31825-X. doi: 10.1016/j.bbrc.2019.09.095. [Epub ahead of print]
Abstract:
Duchenne muscular dystrophy (DMD) is a devastating muscle disorder caused by frameshift mutations in the DMD gene. DMD involves...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: iPSC-derived cardiomyocytes
Citation Extract:
Sato M, Shiba N, Miyazaki D, Shiba Y, Echigoya Y, Yokota T, Takizawa H, Aoki Y, Takeda S, Nakamura A. Amelioration of intracellular Ca2+ regulation by exon-45 skipping in Duchenne muscular dystrophy-induced pluripotent stem cell-derived cardiomyocytes. Biochem Biophys Res Commun. 2019 Oct 1. pii: S0006-291X(19)31825-X. doi: 10.1016/j.bbrc.2019.09.095. [Epub ahead of print].

Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics

Authors:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/791780
Abstract:
Dystrophin plays a vital role in maintaining muscle health, yet low mRNA expression, lengthy transcription time and the...
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Hildyard JCW, Rawson F, Wells DJ, Piercy RJ. Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics. bioRxiv. 2019;[preprint] doi:10.1101/791780 .

ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing

Authors:
Imle R, Wang B-T, Stützenberger N, Birkenhagen J, Tandon A, Carl M, Himmelreich N, Thiel C, Gröne H-J, Poschet G, Völkers M, Gülow K, Schröder A, Carillo S, Mittermayr S, Bones J, Kamiński MM, Kölker S, Sauer SW
Citation:
Sci Rep. 2019;9(1):14248. doi:10.1038/s41598-019-50566-6
Abstract:
Modulation of energy metabolism to a highly glycolytic phenotype, i.e. Warburg effect, is a common phenotype of cancer and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Imle R, Wang B-T, Stützenberger N, Birkenhagen J, Tandon A, Carl M, Himmelreich N, Thiel C, Gröne H-J, Poschet G, Völkers M, Gülow K, Schröder A, Carillo S, Mittermayr S, Bones J, Kamiński MM, Kölker S, Sauer SW. ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing. Sci Rep. 2019;9(1):14248. doi:10.1038/s41598-019-50566-6.

Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract

Authors:
Sidhwani P, Boezio GLM, Yang H, Neil C. Chi NC, Roman BL, Stainier DYR, Yelon D
Citation:
BioRxiv. 2019;[preprint] doi:10.1101/787358
Abstract:
Physical forces are important participants in the cellular dynamics that shape developing organs. During heart formation, for...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sidhwani P, Boezio GLM, Yang H, Neil C. Chi NC, Roman BL, Stainier DYR, Yelon D. Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract. BioRxiv. 2019;[preprint] doi:10.1101/787358 .

Size control of the inner ear via hydraulic feedback

Authors:
Mosaliganti KR, Swinburne IA, Chan CU, Obholzer ND, Green AA, Tanksale S, Mahadevan L, Megason SG
Citation:
Elife. 2019 Oct 1;8. pii: e39596. doi: 10.7554/eLife.39596
Abstract:
Animals make organs of precise size, shape, and symmetry but how developing embryos do this is largely unknown. Here, we...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mosaliganti KR, Swinburne IA, Chan CU, Obholzer ND, Green AA, Tanksale S, Mahadevan L, Megason SG. Size control of the inner ear via hydraulic feedback. Elife. 2019 Oct 1;8. pii: e39596. doi: 10.7554/eLife.39596.

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