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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10164 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology

Authors:
Barnum CE, Al Saai S, Patel SD, Cheng C, Anand D, Xu X, Dash S, Siddam AD, Glazewski L, Paglione E, Polson SW, Chuma S, Mason RW, Wei S, Batish M, Fowler VM, Lachke SA
Citation:
Hum Molec Genet. 2020;[Epub ahead of print] doi:10.1093/hmg/ddaa096
Abstract:
Mutations of the RNA-granule component TDRD7 (OMIM: 611258) cause pediatric cataract. We applied an integrated approach to...
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Barnum CE, Al Saai S, Patel SD, Cheng C, Anand D, Xu X, Dash S, Siddam AD, Glazewski L, Paglione E, Polson SW, Chuma S, Mason RW, Wei S, Batish M, Fowler VM, Lachke SA. The Tudor-domain protein TDRD7, mutated in congenital cataract, controls the heat shock protein HSPB1 (HSP27) and lens fiber cell morphology. Hum Molec Genet. 2020;[Epub ahead of print] doi:10.1093/hmg/ddaa096.

RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function

Authors:
Shi B, Zhang J, Heng J, Gong J, Zhang T, Li P, Sun B-F, Yang Y, Zhang N, Zhao Y-L, Wang H-L, Liu F, Zhang QC, Yang Y-G
Citation:
Genome Biol. 2020;21(1):120 doi:10.1186/s13059-020-02022-2
Abstract:
Background: Vertebrate early embryogenesis is initially directed by a set of maternal RNAs and proteins, yet the mechanisms...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shi B, Zhang J, Heng J, Gong J, Zhang T, Li P, Sun B-F, Yang Y, Zhang N, Zhao Y-L, Wang H-L, Liu F, Zhang QC, Yang Y-G. RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function. Genome Biol. 2020;21(1):120 doi:10.1186/s13059-020-02022-2.

Polarized endosome dynamics engage cytosolic Par-3 and dynein during asymmetric division

Authors:
Zhao X, Tong K, Chen X, Yang B, Li Q, Dai Z, Shi X, Seiple I, Huang B, Guo S
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.15.098012
Abstract:
Asymmetric cell division (ACD), which produces two daughters with different fates, is fundamental for generating cellular...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhao X, Tong K, Chen X, Yang B, Li Q, Dai Z, Shi X, Seiple I, Huang B, Guo S. Polarized endosome dynamics engage cytosolic Par-3 and dynein during asymmetric division. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.15.098012 .

Mycobacteria inhibit neutrophil recruitment to avoid neutrophil-assisted killing by macrophages

Authors:
Ramakrishnan L, Candel S
Citation:
bioRxiv, 2020;[preprint] doi:10.1101/2020.05.14.096032
Abstract:
Neutrophils migrate rapidly to sites of bacterial infection where they mount critical first-line defenses. Puzzlingly,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ramakrishnan L, Candel S. Mycobacteria inhibit neutrophil recruitment to avoid neutrophil-assisted killing by macrophages. bioRxiv, 2020;[preprint] doi:10.1101/2020.05.14.096032.

Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish

Authors:
Demy DL, Campanari M-L, Munoz-Ruiz R,Durham HD, Gentil B, Kabashi E
Citation:
Cells. 2020;9(5):1238 doi:10.3390/cells9051238
Abstract:
Neurofilaments (NFs), a major cytoskeletal component of motor neurons, play a key role in the differentiation, establishment...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Demy DL, Campanari M-L, Munoz-Ruiz R,Durham HD, Gentil B, Kabashi E. Functional Characterization of Neurofilament Light Splicing and Misbalance in Zebrafish. Cells. 2020;9(5):1238 doi:10.3390/cells9051238.

Dach1 regulates neural crest migration during embryonic development

Authors:
Kim Y-K, Lee H, Ismail T, Kim Y, Lee H-S
Citation:
Biochem Biophys Res Comm. 2020;[Epub ahead of print] doi:10.1016/j.bbrc.2020.05.009
Abstract:
Dachshund 1(Dach1) is a key component of the retinal determination gene network that plays significant roles in cell fate...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Kim Y-K, Lee H, Ismail T, Kim Y, Lee H-S. Dach1 regulates neural crest migration during embryonic development. Biochem Biophys Res Comm. 2020;[Epub ahead of print] doi:10.1016/j.bbrc.2020.05.009.

Neuroprotective Brain-Derived Neurotrophic Factor signaling in the TAU-P301L tauopathy zebrafish model

Authors:
Barbereau C, Yehya A, Silhol M, Cubedo N, Verdier JM, Maurice T, Rossel M
Citation:
Pharmacol Res. 2020 May 14:104865. doi: 10.1016/j.phrs.2020.104865. [Epub ahead of print]
Abstract:
Brain-derived neurotrophic factor (BDNF) dysregulations contribute to the neurotoxicity in neurodegenerative pathologies and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Barbereau C, Yehya A, Silhol M, Cubedo N, Verdier JM, Maurice T, Rossel M. Neuroprotective Brain-Derived Neurotrophic Factor signaling in the TAU-P301L tauopathy zebrafish model. Pharmacol Res. 2020 May 14:104865. doi: 10.1016/j.phrs.2020.104865. [Epub ahead of print].

Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence

Authors:
Traver D, Sahai P, Pouget C, Svoboda O
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.14.096305
Abstract:
Development of the dorsal aorta is a key step in the establishment of the adult blood-forming system, since hematopoietic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Traver D, Sahai P, Pouget C, Svoboda O. Dermomyotome-derived endothelial cells migrate to the dorsal aorta to support hematopoietic stem cell emergence. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.14.096305.

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells

Authors:
Michaels WE, Bridges RJ, Hastings ML
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.12.089417
Abstract:
Cystic fibrosis (CF) is an autosomal recessive disorder caused by mutations in the CF transmembrane conductance regulator (CFTR...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: lymphoblast cell lines, hBE cells
Citation Extract:
Michaels WE, Bridges RJ, Hastings ML. Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.12.089417 .

Enzyme-linked oligonucleotide hybridization assay for direct oligo measurement in blood

Authors:
Lorenson MY, Chen KE, Walker AM
Citation:
Biol Methods Protoc. 2019 Jan 7;4(1):bpy014. doi: 10.1093/biomethods/bpy014. eCollection 2019
Abstract:
Small oligonucleotides (oligos) are increasingly being utilized as diagnostics or treatments for disease. An impediment to...
Delivery Method:
Vivo-Morpholino
Citation Extract:
Lorenson MY, Chen KE, Walker AM. Enzyme-linked oligonucleotide hybridization assay for direct oligo measurement in blood. Biol Methods Protoc. 2019 Jan 7;4(1):bpy014. doi: 10.1093/biomethods/bpy014. eCollection 2019.

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