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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12067 scientific papers returned from the database with the search filters currently being used below.

UGT1A1 morpholino antisense oligonucleotides produce mild unconjugated hyperbilirubinemia in cyclosprin A-induced cardiovascular disorders in BLC57 mice

Authors:
Marghani BH, Ateya AI, Othman BH, Rizk MA, El-Adl M
Citation:
Environ Toxicol Pharmacol 2023 Nov 18:104321. doi: 10.1016/j.etap.2023.104321. Online ahead of print
Epub:
Yes
Abstract:
This study aimed to investigate the induction of mild unconjugated hyperbilirubinemia in hepatic UGT1A1 inhibition by...
Delivery Method:
intravenous (i.v.)
Organism or Cell Type:
mice
Citation Extract:
Marghani BH, Ateya AI, Othman BH, Rizk MA, El-Adl M. UGT1A1 morpholino antisense oligonucleotides produce mild unconjugated hyperbilirubinemia in cyclosprin A-induced cardiovascular disorders in BLC57 mice. Environ Toxicol Pharmacol 2023 Nov 18:104321. doi: 10.1016/j.etap.2023.104321. Online ahead of print.

Embryo-scale reverse genetics at single-cell resolution

Authors:
Saunders LM, Srivatsan SR, Duran M, Dorrity MW, Ewing B, Linbo TH, Shendure J, Raible DW, Moens CB, Kimelman D, Trapnell C
Citation:
Nature. 2023 Nov 15. doi: 10.1038/s41586-023-06720-2. Online ahead of print
Epub:
Yes
Abstract:
The maturation of single-cell transcriptomic technologies has facilitated the generation of comprehensive cellular atlases from...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Saunders LM, Srivatsan SR, Duran M, Dorrity MW, Ewing B, Linbo TH, Shendure J, Raible DW, Moens CB, Kimelman D, Trapnell C. Embryo-scale reverse genetics at single-cell resolution. Nature. 2023 Nov 15. doi: 10.1038/s41586-023-06720-2. Online ahead of print.

asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function

Authors:
Cai W, Wang Y, Luo Y, Gao L, Zhang J, Jiang Z, Fan X, Li F, Xie Y, Wu X, Li Y, Yuan W.
Citation:
Int J Mol Sci. 2023;24(22):16364. doi:10.3390/ijms242216364
Epub:
Not Epub
Abstract:
Ankyrin repeat and suppression-of-cytokine-signaling box (Asb) proteins, a subset of ubiquitin ligase E3, include Asb5 with six...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cai W, Wang Y, Luo Y, Gao L, Zhang J, Jiang Z, Fan X, Li F, Xie Y, Wu X, Li Y, Yuan W. . asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. Int J Mol Sci. 2023;24(22):16364. doi:10.3390/ijms242216364 .

Combined RhoA Morpholino and ChABC Treatment Protects Identified Lamprey Neurons from Retrograde Apoptosis after Spinal Cord Injury

Authors:
Hu J, Zhang KG, Rodemer W, Jin L-Q, Selzer ME
Citation:
Front Cell Neurosci. 2023;17:[Epub] doi:10.3389/fncel.2023.1292012
Epub:
Not Epub
Abstract:
Previously, we reported that RhoA knockdown by morpholino antisense oligonucleotides (MOs), and enzymatic digestion of...
Delivery Method:
Gelfoam at lesion
Organism or Cell Type:
lamprey
Citation Extract:
Hu J, Zhang KG, Rodemer W, Jin L-Q, Selzer ME. Combined RhoA Morpholino and ChABC Treatment Protects Identified Lamprey Neurons from Retrograde Apoptosis after Spinal Cord Injury. Front Cell Neurosci. 2023;17:[Epub] doi:10.3389/fncel.2023.1292012.

Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer

Authors:
Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X
Citation:
Drug Deliv Transl Res. 2023 Nov 17. doi: 10.1007/s13346-023-01469-7. Online ahead of print
Epub:
Not Epub
Abstract:
Antisense oligonucleotide (ASO) is a novel therapeutic platform for targeted cancer therapy. Previously, we have demonstrated...
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: SW620, xenograft mice
Citation Extract:
Yu S, Liao R, Bai L, Guo M, Zhang Y, Zhang Y, Yang Q, Song Y, Li Z, Meng Q, Wang S, Huang X. Anticancer effect of hUC-MSC-derived exosome-mediated delivery of PMO-miR-146b-5p in colorectal cancer. Drug Deliv Transl Res. 2023 Nov 17. doi: 10.1007/s13346-023-01469-7. Online ahead of print.

Electrical impedance myography detects dystrophin-related muscle changes in mdx mice

Authors:
Hiyoshi T, Zhao F, Baba R, Hirakawa T, Kuboki R, Suzuki K, Tomimatsu Y, O'Donnell P, Han S, Zach N, Nakashima M
Citation:
Skelet Muscle. 2023 Nov 18;13(1):19. doi: 10.1186/s13395-023-00331-1
Epub:
Not Epub
Abstract:
Background: The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle...
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Hiyoshi T, Zhao F, Baba R, Hirakawa T, Kuboki R, Suzuki K, Tomimatsu Y, O'Donnell P, Han S, Zach N, Nakashima M. Electrical impedance myography detects dystrophin-related muscle changes in mdx mice. Skelet Muscle. 2023 Nov 18;13(1):19. doi: 10.1186/s13395-023-00331-1.

Vangl2 deficient zebrafish exhibit hallmarks of neural tube closure defects

Authors:
MacGowan J, Cardenas M, Williams MK
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.09.566412
Epub:
Not Epub
Abstract:
Neural tube defects (NTDs) are among the most devastating and common congenital anomalies worldwide, and the ability to model...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
MacGowan J, Cardenas M, Williams MK. Vangl2 deficient zebrafish exhibit hallmarks of neural tube closure defects. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.09.566412.

Maternal H3.3-Mediated Paternal Genome Reprogramming Contributes to Minor Zygotic Genome Activation

Authors:
Zhang J, Li X, Cui H, Xiao S, Song E, Zong M, Ling S, Rosenwaks Z, Gao S, Liu X, Kong Q, Wen D
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.07.566007
Epub:
Not Epub
Abstract:
In mice, zygotic genome activation (ZGA) is initiated at the late-one-cell stage, accompanied by an extensive incorporation of...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Zhang J, Li X, Cui H, Xiao S, Song E, Zong M, Ling S, Rosenwaks Z, Gao S, Liu X, Kong Q, Wen D. Maternal H3.3-Mediated Paternal Genome Reprogramming Contributes to Minor Zygotic Genome Activation. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.07.566007.

IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A

Authors:
Gebert M, Bartoszewska S, Opalinski L, Collawn JF, Bartoszewski R
Citation:
Cell Commun Signal. 2023 Nov 9;21(1):322. doi: 10.1186/s12964-023-01349-0
Epub:
Not Epub
Abstract:
The unfolded protein response is a survival signaling pathway that is induced during various types of ER stress. Here, we...
Organism or Cell Type:
cell culture: 16HBE140
Citation Extract:
Gebert M, Bartoszewska S, Opalinski L, Collawn JF, Bartoszewski R. IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A. Cell Commun Signal. 2023 Nov 9;21(1):322. doi: 10.1186/s12964-023-01349-0.

The conserved wobble uridine tRNA thiolase Ctu1 is required to sustain development and differentiation

Authors:
YZW Yu, CQ Wang, Y Wang, H Shi, ZL Zhou
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.08.566201
Epub:
Not Epub
Abstract:
Recent studies have revealed that tRNA modification is an important epigenetic mechanism involved in gene expression. Cytosolic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
YZW Yu, CQ Wang, Y Wang, H Shi, ZL Zhou. The conserved wobble uridine tRNA thiolase Ctu1 is required to sustain development and differentiation. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.08.566201.

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