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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12062 scientific papers returned from the database with the search filters currently being used below.

Electrical impedance myography detects dystrophin-related muscle changes in mdx mice

Authors:
Hiyoshi T, Zhao F, Baba R, Hirakawa T, Kuboki R, Suzuki K, Tomimatsu Y, O'Donnell P, Han S, Zach N, Nakashima M
Citation:
Skelet Muscle. 2023 Nov 18;13(1):19. doi: 10.1186/s13395-023-00331-1
Epub:
Not Epub
Abstract:
Background: The lack of functional dystrophin protein in Duchenne muscular dystrophy (DMD) causes chronic skeletal muscle...
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Hiyoshi T, Zhao F, Baba R, Hirakawa T, Kuboki R, Suzuki K, Tomimatsu Y, O'Donnell P, Han S, Zach N, Nakashima M. Electrical impedance myography detects dystrophin-related muscle changes in mdx mice. Skelet Muscle. 2023 Nov 18;13(1):19. doi: 10.1186/s13395-023-00331-1.

Vangl2 deficient zebrafish exhibit hallmarks of neural tube closure defects

Authors:
MacGowan J, Cardenas M, Williams MK
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.09.566412
Epub:
Not Epub
Abstract:
Neural tube defects (NTDs) are among the most devastating and common congenital anomalies worldwide, and the ability to model...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
MacGowan J, Cardenas M, Williams MK. Vangl2 deficient zebrafish exhibit hallmarks of neural tube closure defects. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.09.566412.

Maternal H3.3-Mediated Paternal Genome Reprogramming Contributes to Minor Zygotic Genome Activation

Authors:
Zhang J, Li X, Cui H, Xiao S, Song E, Zong M, Ling S, Rosenwaks Z, Gao S, Liu X, Kong Q, Wen D
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.07.566007
Epub:
Not Epub
Abstract:
In mice, zygotic genome activation (ZGA) is initiated at the late-one-cell stage, accompanied by an extensive incorporation of...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Zhang J, Li X, Cui H, Xiao S, Song E, Zong M, Ling S, Rosenwaks Z, Gao S, Liu X, Kong Q, Wen D. Maternal H3.3-Mediated Paternal Genome Reprogramming Contributes to Minor Zygotic Genome Activation. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.07.566007.

IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A

Authors:
Gebert M, Bartoszewska S, Opalinski L, Collawn JF, Bartoszewski R
Citation:
Cell Commun Signal. 2023 Nov 9;21(1):322. doi: 10.1186/s12964-023-01349-0
Epub:
Not Epub
Abstract:
The unfolded protein response is a survival signaling pathway that is induced during various types of ER stress. Here, we...
Organism or Cell Type:
cell culture: 16HBE140
Citation Extract:
Gebert M, Bartoszewska S, Opalinski L, Collawn JF, Bartoszewski R. IRE1-mediated degradation of pre-miR-301a promotes apoptosis through upregulation of GADD45A. Cell Commun Signal. 2023 Nov 9;21(1):322. doi: 10.1186/s12964-023-01349-0.

The conserved wobble uridine tRNA thiolase Ctu1 is required to sustain development and differentiation

Authors:
YZW Yu, CQ Wang, Y Wang, H Shi, ZL Zhou
Citation:
bioRxiv. 2023;[preprint] doi:10.1101/2023.11.08.566201
Epub:
Not Epub
Abstract:
Recent studies have revealed that tRNA modification is an important epigenetic mechanism involved in gene expression. Cytosolic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
YZW Yu, CQ Wang, Y Wang, H Shi, ZL Zhou. The conserved wobble uridine tRNA thiolase Ctu1 is required to sustain development and differentiation. bioRxiv. 2023;[preprint] doi:10.1101/2023.11.08.566201.

Optimization and Safety Results of E1v1.11: a morpholino antisense oligonucleotide therapeutic for Spinal Muscular Atrophy

Authors:
Oconnor S, Hansen H, Osman E, Kaifer KD, Morcos P, Kacher M, Beatty D, Lorson C
Citation:
MDA Conference Abstracts. 2024;Poster 85
Epub:
Not Epub
Abstract:
Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder that is the leading genetic cause of infantile death,...
Citation Extract:
Oconnor S, Hansen H, Osman E, Kaifer KD, Morcos P, Kacher M, Beatty D, Lorson C. Optimization and Safety Results of E1v1.11: a morpholino antisense oligonucleotide therapeutic for Spinal Muscular Atrophy. MDA Conference Abstracts. 2024;Poster 85.

Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration

Authors:
Liu C, Liu X, He Z, Zhang J, Tan X, Yang W, Zhang Y, Yu T, Liao S, Dai L, Xu Z, Li F, Huang Y, Zhao J
Citation:
Nat Commun. 2023 Nov 7;14(1):7167. doi: 10.1038/s41467-023-42929-5
Epub:
Not Epub
Abstract:
Organ regeneration necessitates precise coordination of accelerators and brakes to restore organ function. However, the...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Liu C, Liu X, He Z, Zhang J, Tan X, Yang W, Zhang Y, Yu T, Liao S, Dai L, Xu Z, Li F, Huang Y, Zhao J. Proenkephalin-A secreted by renal proximal tubules functions as a brake in kidney regeneration. Nat Commun. 2023 Nov 7;14(1):7167. doi: 10.1038/s41467-023-42929-5.

Abstract 14239: Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve

Authors:
Lin Y, Yang Q, Lin X, Liu X, Kong X, Zhu L, Zhou B, Wang Y, Peng J, Zhu W, Wang J
Citation:
Circulation. 2023;148(Supp 1):A14239
Epub:
Not Epub
Abstract:
Background: Extracellular matrix (ECM) is involved in aortic valve development and aortic valve anomaly. ADAMTS gene mediated...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin Y, Yang Q, Lin X, Liu X, Kong X, Zhu L, Zhou B, Wang Y, Peng J, Zhu W, Wang J. Abstract 14239: Extracellular Matrix Disorganization Caused by ADAMTS16 Deficiency Leads to Bicuspid Aortic Valve. Circulation. 2023;148(Supp 1):A14239 .

Kif21a deficiency leads to impaired glomerular filtration barrier function

Authors:
Riedmann H, Kayser S, Helmstädter M, Epting D, Bergmann C
Citation:
Sci Rep. 2023 Nov 6;13(1):19161. doi: 10.1038/s41598-023-46270-1
Epub:
Not Epub
Abstract:
The renal glomerulus represents the major filtration body of the vertebrate nephron and is responsible for urine production and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Riedmann H, Kayser S, Helmstädter M, Epting D, Bergmann C. Kif21a deficiency leads to impaired glomerular filtration barrier function. Sci Rep. 2023 Nov 6;13(1):19161. doi: 10.1038/s41598-023-46270-1.

Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina

Authors:
Veen K, Krylov A, Yu S, He J, Boyd P, Hyde DR, Mantamadiotis T, Cheng LY, Jusuf PR
Citation:
PLoS Genet. 2023 Nov 6;19(11):e1011010. doi: 10.1371/journal.pgen.1011010. Online ahead of print
Epub:
Not Epub
Abstract:
Damage to light-sensing photoreceptors (PRs) occurs in highly prevalent retinal diseases. As humans cannot regenerate new PRs,...
Delivery Method:
injection then electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Veen K, Krylov A, Yu S, He J, Boyd P, Hyde DR, Mantamadiotis T, Cheng LY, Jusuf PR. Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina. PLoS Genet. 2023 Nov 6;19(11):e1011010. doi: 10.1371/journal.pgen.1011010. Online ahead of print.

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