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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9743 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Otoferlin Depletion Results in Abnormal Synaptic Ribbons and Altered Intracellular Calcium Levels in Zebrafish

Authors:
Manchanda A, Chatterjee P, Bonventre JA, Haggard DE, Kindt KS, Tanguay RL, Johnson CP
Citation:
Sci Rep. 2019;9(1):14273. doi:10.1038/s41598-019-50710-2
Abstract:
The protein otoferlin plays an essential role at the sensory hair cell synapse. Mutations in otoferlin result in deafness and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Manchanda A, Chatterjee P, Bonventre JA, Haggard DE, Kindt KS, Tanguay RL, Johnson CP. Otoferlin Depletion Results in Abnormal Synaptic Ribbons and Altered Intracellular Calcium Levels in Zebrafish. Sci Rep. 2019;9(1):14273. doi:10.1038/s41598-019-50710-2.

VDAC1 is essential for neurite maintenance and the inhibition of its oligomerization protects spinal cord from demyelination and facilitates locomotor function recovery after spinal cord injury

Authors:
Paschon V, Morena BC, Correia FF, Beltrame GR, Dos Santos GB, Cristante AF, Kihara AH
Citation:
Sci Rep. 2019 Oct 1;9(1):14063. doi: 10.1038/s41598-019-50506-4
Abstract:
During the progression of the neurodegenerative process, mitochondria participates in several intercellular signaling pathways...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: rat primary spinal cord
Citation Extract:
Paschon V, Morena BC, Correia FF, Beltrame GR, Dos Santos GB, Cristante AF, Kihara AH. VDAC1 is essential for neurite maintenance and the inhibition of its oligomerization protects spinal cord from demyelination and facilitates locomotor function recovery after spinal cord injury. Sci Rep. 2019 Oct 1;9(1):14063. doi: 10.1038/s41598-019-50506-4.

Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis

Authors:
Sato Y, Hilbert L, Oda H, Wan Y, Heddleston JM, Chew TL, Zaburdaev V, Keller P, Lionnet T, Vastenhouw N, Kimura H
Citation:
Development. 2019 Sep 30;146(19). pii: dev179127. doi: 10.1242/dev.179127
Abstract:
Histone post-translational modifications are key gene expression regulators, but their rapid dynamics during development remain...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sato Y, Hilbert L, Oda H, Wan Y, Heddleston JM, Chew TL, Zaburdaev V, Keller P, Lionnet T, Vastenhouw N, Kimura H. Histone H3K27 acetylation precedes active transcription during zebrafish zygotic genome activation as revealed by live-cell analysis. Development. 2019 Sep 30;146(19). pii: dev179127. doi: 10.1242/dev.179127.

NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress

Authors:
Han D, Schomacher L, Schüle KM, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A, Niehrs C
Citation:
eLife. 2019;8:e49044. doi:10.7554/eLife.49044
Abstract:
Base excision repair (BER) functions not only in the maintenance of genomic integrity but also in active DNA demethylation and...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Han D, Schomacher L, Schüle KM, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A, Niehrs C. NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress. eLife. 2019;8:e49044. doi:10.7554/eLife.49044.

Defective excitatory/inhibitory synaptic balance and increased neuron apoptosis in a zebrafish model of Dravet syndrome

Authors:
Brenet A, Hassan-Abdi R, Somkhit J, Yanicostas C, Soussi-Yanicostas N
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/781393
Abstract:
Dravet syndrome is a type of severe childhood epilepsy that responds poorly to current anti-epileptic drugs. In recent years,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Brenet A, Hassan-Abdi R, Somkhit J, Yanicostas C, Soussi-Yanicostas N. Defective excitatory/inhibitory synaptic balance and increased neuron apoptosis in a zebrafish model of Dravet syndrome. bioRxiv. 2019;[preprint] doi:10.1101/781393.

Preservation of zebrafish genetic resources through testis cryopreservation and spermatogonia transplantation

Authors:
Marinović Z, Li Q, Lujić J, Iwasaki Y, Csenki Z, Urbányi B, Yoshizaki G, Horváth Á
Citation:
Sci Rep. 2019;9(1):13681. doi:10.1038/s41598-019-50169-1
Abstract:
Zebrafish is one of the most commonly used model organisms in biomedical, developmental and genetic research. The production of...
Citation Extract:
Marinović Z, Li Q, Lujić J, Iwasaki Y, Csenki Z, Urbányi B, Yoshizaki G, Horváth Á. Preservation of zebrafish genetic resources through testis cryopreservation and spermatogonia transplantation. Sci Rep. 2019;9(1):13681. doi:10.1038/s41598-019-50169-1.

Characterization of biklf/klf17-deficient zebrafish in posterior lateral line neuromast and hatching gland development

Authors:
Suzuki H, Ishizaka T, Yanagi K, Sone R, Sunaga Y, Ohga R, Kawahara A
Citation:
Sci Rep. 2019;9(1):13680. doi:10.1038/s41598-019-50149-5
Abstract:
Krüpple-like factors (Klfs) are highly conserved zinc-finger transcription factors that regulate various developmental...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Suzuki H, Ishizaka T, Yanagi K, Sone R, Sunaga Y, Ohga R, Kawahara A. Characterization of biklf/klf17-deficient zebrafish in posterior lateral line neuromast and hatching gland development. Sci Rep. 2019;9(1):13680. doi:10.1038/s41598-019-50149-5.

Broadening and Enhancing Functions of Antibody by Self-Assembling Multimerization at Cell Surface

Authors:
Li L, Wang J, Li Y, Radford DC, Yang J, Kopecek J
Citation:
ACS Nano. 2019 Sep 25. doi: 10.1021/acsnano.9b04868. [Epub ahead of print]
Abstract:
Monoclonal antibody therapy has offered treatment benefits. Nonetheless, lack of efficacy still exists, partially because...
Organism or Cell Type:
mice
Citation Extract:
Li L, Wang J, Li Y, Radford DC, Yang J, Kopecek J. Broadening and Enhancing Functions of Antibody by Self-Assembling Multimerization at Cell Surface. ACS Nano. 2019 Sep 25. doi: 10.1021/acsnano.9b04868. [Epub ahead of print].

Reverse Genetic Approaches to Investigate the Neurobiology of the Cnidarian Sea Anemone Nematostella vectensis

Authors:
Havrilak JA, Layden MJ
Citation:
Methods Mol Biol. 2020;2047:25-43. doi: 10.1007/978-1-4939-9732-9_2
Abstract:
The cnidarian sea anemone Nematostella vectensis has grown in popularity as a model system to complement the ongoing work in...
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Havrilak JA, Layden MJ. Reverse Genetic Approaches to Investigate the Neurobiology of the Cnidarian Sea Anemone Nematostella vectensis. Methods Mol Biol. 2020;2047:25-43. doi: 10.1007/978-1-4939-9732-9_2.

Towards the identification of causal genes for age-related macular degeneration

Authors:
Cheng F-F, Zhuang Y-Y, Wen X-R, Xue A, Yang J, Jin Z-B
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/778613
Abstract:
Age-related macular degeneration (AMD) is a leading cause of visual impairment in ageing populations and has no radical...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cheng F-F, Zhuang Y-Y, Wen X-R, Xue A, Yang J, Jin Z-B. Towards the identification of causal genes for age-related macular degeneration. bioRxiv. 2019;[preprint] doi:10.1101/778613 .

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