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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10164 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Authors:
de Calbiac H, Dabacan A, Muresan R, Kabashi E, Ciura S
Citation:
J Vis Exp. 2020:e58837. doi:10.3791/58837
Abstract:
Epilepsy represents one of the most common neurological disorders, affecting an estimated 50 million people worldwide. Recent...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
de Calbiac H, Dabacan A, Muresan R, Kabashi E, Ciura S. Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy. J Vis Exp. 2020:e58837. doi:10.3791/58837.

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

Authors:
Guerra J, Valadao A-L, D. Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, B. Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N
Citation:
Sci Adv. 2020;6(1):eaax3333 doi:10.1126/sciadv.aax3333
Abstract:
Inflammation is an essential part of immunity against pathogens and tumors but can promote disease if not tightly regulated....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Guerra J, Valadao A-L, D. Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, B. Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N. Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation. Sci Adv. 2020;6(1):eaax3333 doi:10.1126/sciadv.aax3333.

Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation

Authors:
Gambini A, Stein A, Savy V, Grow EJ, Papas BN, Zhang Y, Kenan AC, Padilla-Banks E, Cairns BR, Williams CJ
Citation:
Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.04.018
Abstract:
Embryonic genome activation (EGA) is orchestrated by an intrinsic developmental program initiated during oocyte maturation with...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Gambini A, Stein A, Savy V, Grow EJ, Papas BN, Zhang Y, Kenan AC, Padilla-Banks E, Cairns BR, Williams CJ. Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation. Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.04.018.

Complement component C1q plays a critical role in VLRA/VLRC-mediated immune response

Authors:
Li J, Ma Q, Liu H, Song X, Pang Y, Su P, Sun F, Gou M, Lu J, Shan Y, Liu X, Li Q, Han Y
Citation:
Dev Comp Immunol. 2020;[Epub ahead of print] doi:10.1016/j.dci.2020.103750
Abstract:
In jawless vertebrates, the lamprey complement component C1q (LC1q) acts as a lectin and activates lamprey complement component...
Delivery Method:
microinjection
Organism or Cell Type:
Lampetra morii (lamprey)
Citation Extract:
Li J, Ma Q, Liu H, Song X, Pang Y, Su P, Sun F, Gou M, Lu J, Shan Y, Liu X, Li Q, Han Y. Complement component C1q plays a critical role in VLRA/VLRC-mediated immune response. Dev Comp Immunol. 2020;[Epub ahead of print] doi:10.1016/j.dci.2020.103750.

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development

Authors:
Geusz RJ, Wang A, Chiou J, Lancman JJ, Wetton N, Kefalopoulou S, Wang J, Qiu Y, Yan J, Aylward A, Ren B, Dong PDC, Gaulton KJ, Sander M
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.18.101071
Abstract:
Genetic variants associated with type 2 diabetes (T2D) risk affect gene regulation in metabolically relevant tissues, such as...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Geusz RJ, Wang A, Chiou J, Lancman JJ, Wetton N, Kefalopoulou S, Wang J, Qiu Y, Yan J, Aylward A, Ren B, Dong PDC, Gaulton KJ, Sander M. Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.18.101071 .

Cadherin-11 is required for neural crest determination and survival

Authors:
Manohar S, Camacho-Magallanes A, Rogers CD
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.18.066613
Abstract:
Neural crest (NC) cells are multipotent embryonic cells that form melanocytes, craniofacial bone and cartilage, and the...
Delivery Method:
injection then electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Manohar S, Camacho-Magallanes A, Rogers CD. Cadherin-11 is required for neural crest determination and survival. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.18.066613.

Zygotic Vsx1 Plays a Key Role in Defining V2a Interneuron Sub-Lineage by Directly Repressing tal1 Transcription in Zebrafish

Authors:
Zhang Q, Xu H, Zhao W, Zheng J, Sun L, Luo C
Citation:
Int J Mol Sci. 2020;21(10):2020. doi:10.3390/ijms21103600
Abstract:
In the spinal cord, excitatory V2a and inhibitory V2b interneurons are produced together by the final division of common P2...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang Q, Xu H, Zhao W, Zheng J, Sun L, Luo C. Zygotic Vsx1 Plays a Key Role in Defining V2a Interneuron Sub-Lineage by Directly Repressing tal1 Transcription in Zebrafish. Int J Mol Sci. 2020;21(10):2020. doi:10.3390/ijms21103600.

Identification of Transient Receptor Potential Channel 4-Associated Protein as a Novel Candidate Gene Causing Congenital Primary Hypothyroidism

Authors:
Choukair D, Eberle B, Vick P, Hermanns P, Weiss B, Paramasivam N, Schlesner M, Lornsen K, Roeth R, Klutmann C, Kreis J, Hoffmann GF, Pohlenz J, Rappold GA, Bettendorf M
Citation:
Horm Res Paediatr. 2020;[Epub aheaed of print] doi:10.1159/000507114
Abstract:
Background: Congenital primary hypothyroidism (CH) is the most common endocrine disorder in neonates. Methods: To identify...
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Choukair D, Eberle B, Vick P, Hermanns P, Weiss B, Paramasivam N, Schlesner M, Lornsen K, Roeth R, Klutmann C, Kreis J, Hoffmann GF, Pohlenz J, Rappold GA, Bettendorf M. Identification of Transient Receptor Potential Channel 4-Associated Protein as a Novel Candidate Gene Causing Congenital Primary Hypothyroidism. Horm Res Paediatr. 2020;[Epub aheaed of print] doi:10.1159/000507114.

Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish

Authors:
El Maï M, Marzullo M, de Castro IP, Ferreira MG
Citation:
eLife. 2020;9:e54935. doi:10.7554/eLife.54935
Abstract:
Progressive telomere shortening during lifespan is associated with restriction of cell proliferation, genome instability and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
El Maï M, Marzullo M, de Castro IP, Ferreira MG. Opposing p53 and mTOR/AKT promote an in vivo switch from apoptosis to senescence upon telomere shortening in zebrafish. eLife. 2020;9:e54935. doi:10.7554/eLife.54935.

De novo mutations in FBRSL1 cause a novel recognizable malformation and intellectual disability syndrome

Authors:
Ufartes R, Berger H, Till K, Salinas G, Sturm M, Altmüller J, Nürnberg P, Thiele H, Funke R, Apeshiotis N, Langen H, Wollnik B, Borchers A, Pauli S
Citation:
Hum Genet. 2020 May 18. doi: 10.1007/s00439-020-02175-x. Online ahead of print
Abstract:
We report truncating de novo variants in specific exons of FBRSL1 in three unrelated children with an overlapping syndromic...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Ufartes R, Berger H, Till K, Salinas G, Sturm M, Altmüller J, Nürnberg P, Thiele H, Funke R, Apeshiotis N, Langen H, Wollnik B, Borchers A, Pauli S. De novo mutations in FBRSL1 cause a novel recognizable malformation and intellectual disability syndrome. Hum Genet. 2020 May 18. doi: 10.1007/s00439-020-02175-x. Online ahead of print.

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