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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10930 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells

Authors:
Lai JKH, Toh PJY, Cognart HA, Chouhan G, Saunders TE
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.07.23.453490
Epub:
Not Epub
Abstract:
In a previous study, it was reported that Yap1 and Wwtr1 in zebrafish regulates the morphogenesis of the posterior body and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lai JKH, Toh PJY, Cognart HA, Chouhan G, Saunders TE. DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells. bioRxiv. 2021;[preprint] doi:10.1101/2021.07.23.453490.

Zic1 advances epaxial myotome morphogenesis to cover the neural tube via Wnt11r

Authors:
Heilig AK, Nakamura R, Shimada A, Hashimoto Y, Nakamura Y, Wittbrodt J, Takeda H, Kawanishi T
Citation:
bioRxiv. 20219;[preprint] doi:/10.1101/2021.07.12.452069
Epub:
Not Epub
Abstract:
The dorsal axial muscles, or epaxial muscles, are a fundamental structure covering the spinal cord and vertebrae, as well as...
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Heilig AK, Nakamura R, Shimada A, Hashimoto Y, Nakamura Y, Wittbrodt J, Takeda H, Kawanishi T. Zic1 advances epaxial myotome morphogenesis to cover the neural tube via Wnt11r. bioRxiv. 20219;[preprint] doi:/10.1101/2021.07.12.452069.

The E3 Ubiquitin Ligase Mindbomb1 controls zebrafish Planar Cell Polarity

Authors:
Saraswathy VM, Sharma P, Kurup AJ, Polès S, Poulain M, Fürthauer M
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.07.05.451064
Epub:
Not Epub
Abstract:
Vertebrate Delta/Notch signaling involves multiple ligands, receptors and transcription factors. Delta endocytosis – a critical...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Saraswathy VM, Sharma P, Kurup AJ, Polès S, Poulain M, Fürthauer M. The E3 Ubiquitin Ligase Mindbomb1 controls zebrafish Planar Cell Polarity. bioRxiv. 2021;[preprint] doi:10.1101/2021.07.05.451064 .

Fluorescence Correlation Spectroscopy Reveals Survival Motor Neuron Oligomerization but No Active Transport in Motor Axons of a Zebrafish Model for Spinal Muscular Atrophy

Authors:
Koh A, Sarusie MV, Ohmer J, Fischer U, Winkler C and Wohland T
Citation:
Front Cell Dev Biol. 2021;9:639904. doi:10.3389/fcell.2021.639904
Epub:
Not Epub
Abstract:
Spinal Muscular Atrophy (SMA) is a progressive neurodegenerative disease affecting lower motor neurons that is caused by a...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Koh A, Sarusie MV, Ohmer J, Fischer U, Winkler C and Wohland T. Fluorescence Correlation Spectroscopy Reveals Survival Motor Neuron Oligomerization but No Active Transport in Motor Axons of a Zebrafish Model for Spinal Muscular Atrophy. Front Cell Dev Biol. 2021;9:639904. doi:10.3389/fcell.2021.639904.

A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis

Authors:
Pradella D, Deflorian G, Pezzotta A, Di Matteo A, Belloni E, Campolungo D, Paradisi A, Bugatti M, Vermi W, Campioni M, Chiapparino A, Scietti L, Forneris F, Giampietro C, Volf N, Rehman M, Zacchigna S, Paronetto MP, Pistocchi A, Eichmann A, Mehlen P, Ghigna C
Citation:
Nat Comm. 2021;12(1):4872. doi:10.1038/s41467-021-24998-6
Epub:
Not Epub
Abstract:
The Netrin-1 receptor UNC5B is an axon guidance regulator that is also expressed in endothelial cells (ECs), where it finely...
Delivery Method:
Endo-Porter, microinjection
Organism or Cell Type:
cell culture: HUVEC/TERT2, zebrafish
Citation Extract:
Pradella D, Deflorian G, Pezzotta A, Di Matteo A, Belloni E, Campolungo D, Paradisi A, Bugatti M, Vermi W, Campioni M, Chiapparino A, Scietti L, Forneris F, Giampietro C, Volf N, Rehman M, Zacchigna S, Paronetto MP, Pistocchi A, Eichmann A, Mehlen P, Ghigna C. A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis. Nat Comm. 2021;12(1):4872. doi:10.1038/s41467-021-24998-6.

The miR-430 locus with extreme promoter density is a transcription body organizer, which facilitates long range regulation in zygotic genome activation

Authors:
Hadzhiev Y, Wheatley L, Cooper L, Ansaloni F, Whalley C, Chen Z, Gustincich S, Sanges R, Burgess SM, Beggs AD, Mueller FD
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.08.09.455629
Epub:
Not Epub
Abstract:
In anamniote embryos the major wave of zygotic genome activation (ZGA) starts during the mid-blastula transition. This major...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hadzhiev Y, Wheatley L, Cooper L, Ansaloni F, Whalley C, Chen Z, Gustincich S, Sanges R, Burgess SM, Beggs AD, Mueller FD. The miR-430 locus with extreme promoter density is a transcription body organizer, which facilitates long range regulation in zygotic genome activation. bioRxiv. 2021;[preprint] doi:10.1101/2021.08.09.455629.

Twisting of the zebrafish heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process

Authors:
Tessadori F, Tsingos E, Colizzi ES, Kruse F, van den Brink SC, van den Boogaard M, Christoffels VM, Merks RM, Bakkers J
Citation:
Elife. 2021 Aug 10;10:e61733. doi: 10.7554/eLife.61733
Epub:
Not Epub
Abstract:
Organ laterality refers to the left-right asymmetry in disposition and conformation of internal organs and is established...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tessadori F, Tsingos E, Colizzi ES, Kruse F, van den Brink SC, van den Boogaard M, Christoffels VM, Merks RM, Bakkers J. Twisting of the zebrafish heart tube during cardiac looping is a tbx5-dependent and tissue-intrinsic process. Elife. 2021 Aug 10;10:e61733. doi: 10.7554/eLife.61733.

Who is the best surrogate for germ stem cell transplantation in fish?

Authors:
Franěk R, Cheng Y, Fučíková M, Kašpar V, Xie X, Shah MA, Linhart O, Sauman I, Pšenička
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.08.09.455047
Epub:
Not Epub
Abstract:
Surrogate reproduction technology in fish has potential for aquaculture as well as endangered species preservation and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Franěk R, Cheng Y, Fučíková M, Kašpar V, Xie X, Shah MA, Linhart O, Sauman I, Pšenička. Who is the best surrogate for germ stem cell transplantation in fish?. bioRxiv. 2021;[preprint] doi:10.1101/2021.08.09.455047.

Krüppel-like factor gene function in the ctenophore Mnemiopsis leidyi assessed by CRISPR/Cas9-mediated genome editing

Authors:
Presnell JS, Browne WE
Citation:
Development. 2021 Aug 10:dev.199771. doi: 10.1242/dev.199771. Online ahead of print
Epub:
Yes
Abstract:
The Krüppel-like factor (Klf) gene family encodes for transcription factors that play an important role in the regulation of...
Organism or Cell Type:
Mnemiopsis leidyi (ctenophore)
Citation Extract:
Presnell JS, Browne WE. Krüppel-like factor gene function in the ctenophore Mnemiopsis leidyi assessed by CRISPR/Cas9-mediated genome editing. Development. 2021 Aug 10:dev.199771. doi: 10.1242/dev.199771. Online ahead of print.

Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development

Authors:
Kuil LE, MacKenzie KC, Tang CS, Windster JD, Le TL, Karim A, de Graaf BM, van der Helm R, van Bever Y, Sloots CEJ, Meeussen C, Tibboel D, de Klein A, Wijnen RMH, Amiel J, Lyonnet S, Garcia-Barcelo M-M, Tam PKH, Alves MM, Brooks AS, Hofstra RMW, Brosens E
Citation:
PLoS Genet. 2021;17(8):e1009698. doi:10.1371/journal.pgen.1009698
Epub:
Not Epub
Abstract:
Hirschsprung disease (HSCR) is a complex genetic disease characterized by absence of ganglia in the intestine. HSCR etiology...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kuil LE, MacKenzie KC, Tang CS, Windster JD, Le TL, Karim A, de Graaf BM, van der Helm R, van Bever Y, Sloots CEJ, Meeussen C, Tibboel D, de Klein A, Wijnen RMH, Amiel J, Lyonnet S, Garcia-Barcelo M-M, Tam PKH, Alves MM, Brooks AS, Hofstra RMW, Brosens E. Size matters: Large copy number losses in Hirschsprung disease patients reveal genes involved in enteric nervous system development. PLoS Genet. 2021;17(8):e1009698. doi:10.1371/journal.pgen.1009698.

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