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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10704 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Lamb1a regulates atrial growth by limiting excessive, contractility-dependent second heart field addition during zebrafish heart development

Authors:
Derrick CJ, Pollitt EJG, Uruchurtu ASS, Hussein F, Noel ES
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.10.434727
Abstract:
During early vertebrate heart development, the heart transitions from a linear tube to a complex asymmetric structure. This...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Derrick CJ, Pollitt EJG, Uruchurtu ASS, Hussein F, Noel ES. Lamb1a regulates atrial growth by limiting excessive, contractility-dependent second heart field addition during zebrafish heart development. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.10.434727 .

Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients

Authors:
Signorelli M, Ebrahimpoor M, Veth O, Hettne K, Verwey N, García‐Rodríguez R, Tanganyika‐deWinter CL, Lopez Hernandez LB, Cedillo RE, Díaz BG, Magnusson OT, Mei H, Tsonaka R, Aartsma‐Rus A, Spitali P
Citation:
EMBO Mol Med. 2021;e13328. doi:10.15252/emmm.202013328
Abstract:
DMD is a rare disorder characterized by progressive muscle degeneration and premature death. Therapy development is delayed by...
Delivery Method:
i.v. injection
Organism or Cell Type:
mice mdx
Citation Extract:
Signorelli M, Ebrahimpoor M, Veth O, Hettne K, Verwey N, García‐Rodríguez R, Tanganyika‐deWinter CL, Lopez Hernandez LB, Cedillo RE, Díaz BG, Magnusson OT, Mei H, Tsonaka R, Aartsma‐Rus A, Spitali P. Peripheral blood transcriptome profiling enables monitoring disease progression in dystrophic mice and patients. EMBO Mol Med. 2021;e13328. doi:10.15252/emmm.202013328.

Exome sequencing and functional studies in zebrafish identify WDR8 as the causative gene for isolated Microspherophakia in Indian families

Authors:
Madhangi M, Dutta D, Show S, Bhat VK, Rather MI, Tiwari A, Singh N, Duvvari MR, Murthy GJ, Kumar A, Nongthomba U
Citation:
Hum Mol Genet. 2021;ddab061. doi:10.1093/hmg/ddab061
Abstract:
Isolated Microspherophakia (MSP) is an autosomal recessive disorder characterised by a smaller than normal spherical lens. Till...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Madhangi M, Dutta D, Show S, Bhat VK, Rather MI, Tiwari A, Singh N, Duvvari MR, Murthy GJ, Kumar A, Nongthomba U. Exome sequencing and functional studies in zebrafish identify WDR8 as the causative gene for isolated Microspherophakia in Indian families. Hum Mol Genet. 2021;ddab061. doi:10.1093/hmg/ddab061.

An early global role for Axin is required for correct patterning of the anterior-posterior axis in the sea urchin embryo

Authors:
Sun H, Peng CFJ, Wang L, Feng H, Wikramanayake AH
Citation:
Development. 2021;dev.191197 doi:10.1242/dev.191197
Abstract:
Activation of Wnt/β-catenin (cWnt) signaling at the future posterior end of early bilaterian embryos is a highly conserved...
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus & Lytechinus variegatus (sea urchin)
Citation Extract:
Sun H, Peng CFJ, Wang L, Feng H, Wikramanayake AH . An early global role for Axin is required for correct patterning of the anterior-posterior axis in the sea urchin embryo. Development. 2021;dev.191197 doi:10.1242/dev.191197.

Characterization of quinoxaline derivatives for protection against iatrogenically induced hearing loss

Authors:
Zallocchi M, Hati S, Xu Z, Hausman W, Liu H, He DZ, Zuo J
Citation:
JCI Insight. 2021 Mar 8;6(5):141561. doi: 10.1172/jci.insight.141561
Abstract:
Hair cell loss is the leading cause of hearing and balance disorders in humans. It can be caused by many factors, including...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zallocchi M, Hati S, Xu Z, Hausman W, Liu H, He DZ, Zuo J. Characterization of quinoxaline derivatives for protection against iatrogenically induced hearing loss. JCI Insight. 2021 Mar 8;6(5):141561. doi: 10.1172/jci.insight.141561.

The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos

Authors:
Massé K, Bhamra S, Paroissin C, Maneta-Peyret L, Boué-Grabot E, Jones EA
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.04.433320
Abstract:
The enpp ectonucleotidases regulate lipidic and purinergic signalling pathways by controlling the extracellular concentrations...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Massé K, Bhamra S, Paroissin C, Maneta-Peyret L, Boué-Grabot E, Jones EA. The enpp4 ectonucleotidase regulates kidney patterning signalling networks in Xenopus embryos. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.04.433320.

Mechanism and consequences of herpes simplex virus 1-mediated regulation of host mRNA alternative polyadenylation

Authors:
Wang X, Liu L, Whisnant AW, Hennig T, Djakovic L, Haque N, Bach C, Sandri-Goldin RM, Erhard F, Friedel CC, Dölken L, Shi Y
Citation:
PLoS Genet. 2021;17(3):e1009263. doi:10.1371/journal.pgen.1009263
Abstract:
Eukaryotic gene expression is extensively regulated by cellular stress and pathogen infections. We have previously shown that...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: HEK293
Citation Extract:
Wang X, Liu L, Whisnant AW, Hennig T, Djakovic L, Haque N, Bach C, Sandri-Goldin RM, Erhard F, Friedel CC, Dölken L, Shi Y. Mechanism and consequences of herpes simplex virus 1-mediated regulation of host mRNA alternative polyadenylation. PLoS Genet. 2021;17(3):e1009263. doi:10.1371/journal.pgen.1009263.

Stepwise candidate drug screening for myopia control by using zebrafish, mouse, and Golden Syrian Hamster myopia models

Authors:
Lin M-Y, Lin I-T, Wu Y-C, Wang I-J
Citation:
EBioMedicine. 2021;65:103263. doi:10.1016/j.ebiom.2021.103263
Abstract:
Background: We developed a preclinical protocol for the screening of candidate drugs able to control myopia and prevent its...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin M-Y, Lin I-T, Wu Y-C, Wang I-J. Stepwise candidate drug screening for myopia control by using zebrafish, mouse, and Golden Syrian Hamster myopia models. EBioMedicine. 2021;65:103263. doi:10.1016/j.ebiom.2021.103263.

Conditional gene knockdowns in sea urchins using caged morpholinos

Authors:
Bardhan A, Deiters A, Ettensohn CA
Citation:
Dev Biol . 2021 Mar 5;475:21-29. doi: 10.1016/j.ydbio.2021.02.014
Abstract:
Sea urchins and other echinoderms are important experimental models for analyzing embryonic development, but a lack of spatial...
Delivery Method:
microinjection
Organism or Cell Type:
sea urchin
Citation Extract:
Bardhan A, Deiters A, Ettensohn CA. Conditional gene knockdowns in sea urchins using caged morpholinos. Dev Biol . 2021 Mar 5;475:21-29. doi: 10.1016/j.ydbio.2021.02.014.

The altered expression of neurofilament in mouse models and patients with spinal muscular atrophy

Authors:
Spicer C, Lu CH, Catapano F, Scoto M, Zaharieva I, Malaspina A, Morgan JE, Greensmith L, Muntoni F, Zhou H
Citation:
Ann Clin Transl Neurol. 2021 Mar 8. doi: 10.1002/acn3.51336. Online ahead of print
Abstract:
Objectives: To investigate the levels of neurofilaments (NFs) in transgenic mice and patients with spinal muscular atrophy (SMA...
Delivery Method:
s.c. (subcutaneous) injection
Organism or Cell Type:
severe SMA mice
Citation Extract:
Spicer C, Lu CH, Catapano F, Scoto M, Zaharieva I, Malaspina A, Morgan JE, Greensmith L, Muntoni F, Zhou H. The altered expression of neurofilament in mouse models and patients with spinal muscular atrophy. Ann Clin Transl Neurol. 2021 Mar 8. doi: 10.1002/acn3.51336. Online ahead of print.

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