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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12198 scientific papers returned from the database with the search filters currently being used below.
There are 12198 scientific papers returned from the database with the search filters currently being used below.
Enhancing Peptide and PMO Delivery to Mouse Airway Epithelia by Chemical Conjugation with the Amphiphilic Peptide S10
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Citation:
Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102290 Epub:
Not Epub Abstract:
Delivery of antisense oligonucleotides (ASOs) to airway epithelial cells is arduous due to the physiological barriers that... Delivery Method:
intranasal peptide-linked Organism or Cell Type:
cell culture: HeLa EGFP-654, mice: CAG-EGFP-654 Citation Extract: Auger M, Sorroza-Martinez L, Brahiti N, Huppé C-A, Faucher-Giguère L, Arbi I, Hervault M, Cheng X, Gaillet B, Couture F, Guay D, Soultan A-H. Enhancing Peptide and PMO Delivery to Mouse Airway Epithelia by Chemical Conjugation with the Amphiphilic Peptide S10. Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102290. |
CRISPR-Cas13d as a molecular tool to achieve targeted gene expression knockdown in chick embryos
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Citation:
bioRxiv [preprint] 2024.08.03.606488; doi: https://doi.org/10.1101/2024.08.03.606488 Epub:
Not Epub Abstract:
The chick embryo is a classical model system commonly used in developmental biology due to its amenability to gene perturbation... Delivery Method:
electroporation Organism or Cell Type:
chick embryo Citation Extract: Kim M & Hutchins EJ. CRISPR-Cas13d as a molecular tool to achieve targeted gene expression knockdown in chick embryos. bioRxiv [preprint] 2024.08.03.606488; doi: https://doi.org/10.1101/2024.08.03.606488. |
Tailored antisense oligonucleotides designed to correct aberrant splicing reveal actionable groups of mutations for rare genetic disorders
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Citation:
Exp Mol Med (2024). https://doi.org/10.1038/s12276-024-01292-1 Epub:
Not Epub Abstract:
Effective translation of rare disease diagnosis knowledge into therapeutic applications is achievable within a reasonable... Delivery Method:
Vivo-Morpholinos, bare Morpholinos, Endo-Porter Organism or Cell Type:
HEK293 cells Citation Extract: Wai HA, Svobodova E, Herrera NR, Douglas AGL, Holloway JW, Baralle FE, Baralle M, Baralle D. Tailored antisense oligonucleotides designed to correct aberrant splicing reveal actionable groups of mutations for rare genetic disorders. Exp Mol Med (2024). https://doi.org/10.1038/s12276-024-01292-1. |
Cdon is required for organ Left-Right patterning via regulating DFCs migration and the sequential ciliogenesis
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Citation:
bioRxiv [preprint] 2024.03.12.584572; doi: https://doi.org/10.1101/2024.03.12.584572 Epub:
Not Epub Abstract:
Cdon and boc are members of the cell adhesion molecule subfamily III Ig/fibronectin. Although they were reported to be involved... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Deng Z, Chang W, Li C, Li B, Huang S, Huang J, Zhang K, Li Y, Liu X, Ran Q, Guo Z, Huang S. Cdon is required for organ Left-Right patterning via regulating DFCs migration and the sequential ciliogenesis. bioRxiv [preprint] 2024.03.12.584572; doi: https://doi.org/10.1101/2024.03.12.584572. |
Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish
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Citation:
BMC Biol. 2024 Jul 29;22(1):163. doi: 10.1186/s12915-024-01961-7. PMID: 39075492; PMCID: PMC11288053 Epub:
Not Epub Abstract:
BACKGROUND: Energy allocation between growth and reproduction determines puberty onset and fertility. In mammals, peripheral... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Chen J, Zhao W, Cao L, Martins RST, Canário AVM. Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biol. 2024 Jul 29;22(1):163. doi: 10.1186/s12915-024-01961-7. PMID: 39075492; PMCID: PMC11288053. |
Leucine-Rich Repeat Kinase-2 Controls the Differentiation and Maturation of Oligodendrocytes in Mice and Zebrafish
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Citation:
Biomolecules. 2024; 14(7):870. https://doi.org/10.3390/biom14070870 Epub:
Not Epub Abstract:
Leucine-rich repeat kinase-2 (LRRK2), a gene mutated in familial and sporadic Parkinson’s disease (PD), controls multiple... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Filippini A, Cannone E, Mazziotti V, Carini G, Mutti V, Ravelli C, Gennarelli M, Schiavone M, Russo I. Leucine-Rich Repeat Kinase-2 Controls the Differentiation and Maturation of Oligodendrocytes in Mice and Zebrafish. Biomolecules. 2024; 14(7):870. https://doi.org/10.3390/biom14070870. |
SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function
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Citation:
bioRxiv [preprint] 2024.07.21.604148; doi: https://doi.org/10.1101/2024.07.21.604148 Epub:
Not Epub Abstract:
Syntenic conservation is an effective strategy to identify evolutionarily conserved lncRNA orthologs. In this study, we... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Ranjan G, Sehgal P, Scaria V, Sivasubbu S. SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function. bioRxiv [preprint] 2024.07.21.604148; doi: https://doi.org/10.1101/2024.07.21.604148. |
Sall4 regulates downstream patterning genes during limb regeneration
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Citation:
Dev Biol. 2024 Jul 25:S0012-1606(24)00195-7. doi: 10.1016/j.ydbio.2024.07.015. Epub ahead of print. PMID: 39067503. Epub:
Not Epub Abstract:
Many salamanders can completely regenerate a fully functional limb. Limb regeneration is a carefully coordinated process... Delivery Method:
injection then electroporation Organism or Cell Type:
Ambystoma mexicanum (Axolotl) Citation Extract: Erickson JR, Walker SE, Arenas Gomez C, Echeverri K. Sall4 regulates downstream patterning genes during limb regeneration. Dev Biol. 2024 Jul 25:S0012-1606(24)00195-7. doi: 10.1016/j.ydbio.2024.07.015. Epub ahead of print. PMID: 39067503.. |
Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin and empagliflozin induced arterial relaxation
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Citation:
Cardiovasc Res. 2024 Jul 26:cvae156. doi: 10.1093/cvr/cvae156. Epub ahead of print. PMID: 39056245. Epub:
Not Epub Abstract:
Aims: Sodium/glucose transporter 2 (SGLT2 or SLC5A2) inhibitors lower blood glucose and are also approved treatments for heart... Delivery Method:
Lipofectamine 2000 Organism or Cell Type:
NHE1 knockout mouse explant: mesenteric arteries Citation Extract: Forrester EA, Benítez-Angeles M, Redford KE, Rosenbaum T, Abbott GW, Barrese V, Dora K, Albert AP, Dannesboe J, Salles-Crawley I, Jepps TA, Greenwood IA. Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin and empagliflozin induced arterial relaxation. Cardiovasc Res. 2024 Jul 26:cvae156. doi: 10.1093/cvr/cvae156. Epub ahead of print. PMID: 39056245.. |
CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression
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Citation:
Biomolecules. 2024; 14(8):914 Epub:
Not Epub Abstract:
Carnitine palmitoyltransferase 2 (CPT2) is an inner mitochondrial membrane protein of the carnitine shuttle and is involved in... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Baker CE, Marta AG, Zimmerman ND, Korade Z, Mathy NW, Wilton D, Simeone T, Kochvar A, Kramer KL, Stessman HAF, Shibata A. CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression. Biomolecules. 2024; 14(8):914. |