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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9646 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Spatio-temporal expression of ANK2 promotes cytokinesis in oocytes

Authors:
Tetkova A, Jansova D, Susor A
Citation:
Sci Rep. 2019;9(1):13121. doi:10.1038/s41598-019-49483-5
Abstract:
In the absence of transcription, the regulation of gene expression in oocytes is controlled almost exclusively at the level of...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Tetkova A, Jansova D, Susor A. Spatio-temporal expression of ANK2 promotes cytokinesis in oocytes. Sci Rep. 2019;9(1):13121. doi:10.1038/s41598-019-49483-5.

SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring

Authors:
Sessa A, Fagnocchi L, Mastrototaro G, Massimino L, Zaghi M, Indrigo M, Cattaneo S, Martini D, Gabellini C, Pucci C, Fasciani A, Belli R, Taverna S, Andreazzoli M, Zippo A, Broccoli V
Citation:
Neuron. 2019;104:{Epub ahead of print] doi:10.1016/j.neuron.2019.07.013
Abstract:
Mutations in one SETD5 allele are genetic causes of intellectual disability and autistic spectrum disorders. However, the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sessa A, Fagnocchi L, Mastrototaro G, Massimino L, Zaghi M, Indrigo M, Cattaneo S, Martini D, Gabellini C, Pucci C, Fasciani A, Belli R, Taverna S, Andreazzoli M, Zippo A, Broccoli V. SETD5 Regulates Chromatin Methylation State and Preserves Global Transcriptional Fidelity during Brain Development and Neuronal Wiring. Neuron. 2019;104:{Epub ahead of print] doi:10.1016/j.neuron.2019.07.013.

RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery

Authors:
Chatrikhi R, Mallory MJ, Gazzara MR, Agosto LM, Zhu WS, Litterman AJ, Ansel KM, Lynch KW
Citation:
Cell Rep. 2019;28(11):P2795-806. doi:10.1016/j.celrep.2019.08.022
Abstract:
The 3′ UTR (UTR) of human mRNAs plays a critical role in controlling protein expression and function. Importantly, 3′ UTRs of...
Delivery Method:
elecroporation
Organism or Cell Type:
cell culture: Jurkat
Citation Extract:
Chatrikhi R, Mallory MJ, Gazzara MR, Agosto LM, Zhu WS, Litterman AJ, Ansel KM, Lynch KW. RNA Binding Protein CELF2 Regulates Signal-Induced Alternative Polyadenylation by Competing with Enhancers of the Polyadenylation Machinery. Cell Rep. 2019;28(11):P2795-806. doi:10.1016/j.celrep.2019.08.022.

Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition

Authors:
Zhao W, Cao L, Ying H, Zhang W, Li D, Zhu X, Xue W, Wu S, Cao M, Fu C, Qi H, Hao Y, Tang Y-C, Qin J, Zhong TP, Lin X, Yu L, Li X, Li L, Wu D, Pan W
Citation:
Cell Res. 2019;[Epub] doi:10.1038/s41422-019-0229-5
Abstract:
The response of endothelial cells to signaling stimulation is critical for vascular morphogenesis, homeostasis and function....
Delivery Method:
microinjection, Vivo-Morpholino
Organism or Cell Type:
zebrafish, xenograft mice
Citation Extract:
Zhao W, Cao L, Ying H, Zhang W, Li D, Zhu X, Xue W, Wu S, Cao M, Fu C, Qi H, Hao Y, Tang Y-C, Qin J, Zhong TP, Lin X, Yu L, Li X, Li L, Wu D, Pan W. Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Res. 2019;[Epub] doi:10.1038/s41422-019-0229-5.

Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

Authors:
Wei L, Al Oustah A, Blader P, Roussigné M
Citation:
Elife. 2019 Sep 9;8. pii: e46275. doi: 10.7554/eLife.46275
Abstract:
Coordinated migration of cell collectives is important during embryonic development and relies on cells integrating multiple...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wei L, Al Oustah A, Blader P, Roussigné M. Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration. Elife. 2019 Sep 9;8. pii: e46275. doi: 10.7554/eLife.46275.

Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness

Authors:
Cayuso J, Xu Q, Addison M, Wilkinson DG
Citation:
eLife. 2019;8:e49696. doi:10.7554/eLife.49696
Abstract:
The segregation of cells with distinct regional identity underlies formation of a sharp border, which in some tissues serves to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cayuso J, Xu Q, Addison M, Wilkinson DG. Actomyosin regulation by Eph receptor signaling couples boundary cell formation to border sharpness. eLife. 2019;8:e49696. doi:10.7554/eLife.49696.

Functional analysis of new human Bardet-Biedl syndrome loci specific variants in the zebrafish model

Authors:
Castro-Sánchez S, Suarez-Bregua P, Novas R, Álvarez-Satta M, Badano JL, Rotllant J, Valverde D
Citation:
Sci Rep. 2019;9(1):12936. doi:10.1038/s41598-019-49217-7
Abstract:
The multiple genetic approaches available for molecular diagnosis of human diseases have made possible to identify an...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Castro-Sánchez S, Suarez-Bregua P, Novas R, Álvarez-Satta M, Badano JL, Rotllant J, Valverde D. Functional analysis of new human Bardet-Biedl syndrome loci specific variants in the zebrafish model. Sci Rep. 2019;9(1):12936. doi:10.1038/s41598-019-49217-7.

Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides

Authors:
Aung-Htut MT, Comerford I, Johnsen R, Foyle K, Fletcher S, Wilton SD
Citation:
Sci Rep. 2019;9(1):12994. doi:10.1038/s41598-019-49385-6
Abstract:
With recent approvals of antisense oligonucleotides as therapeutics, there is an increasing interest in expanding the...
Delivery Method:
in vitro lipofectamine (fibroblasts) electroporation (Jurkat) , in vivo peptide-linked
Organism or Cell Type:
cell culture: primary dermal fibroblasts, Jurkat; autoimmune encephalomyelitis mouse model of multiple sclerosis
Citation Extract:
Aung-Htut MT, Comerford I, Johnsen R, Foyle K, Fletcher S, Wilton SD. Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides. Sci Rep. 2019;9(1):12994. doi:10.1038/s41598-019-49385-6.

Identification of a Novel Deep Intronic Mutation in CAPN3 Presenting a Promising Target for Therapeutic Splice Modulation

Authors:
Hu Y, Mohassel P, Donkervoort S, Yun P, Bolduc V, Ezzo D, Dastgir J, Marshall JL, Lek M, MacArthur DG, Reghan Foley A, Bönnemann CG
Citation:
J Neuromuscul Dis. 2019 Aug 31. doi: 10.3233/JND-190414. [Epub ahead of print]
Abstract:
Calpainopathy, also known as limb girdle muscular dystrophy (LGMD) type 2A (LGMD2A) or LGMD R1 Calpain3-related, is one of the...
Organism or Cell Type:
cell culture: primary cells
Citation Extract:
Hu Y, Mohassel P, Donkervoort S, Yun P, Bolduc V, Ezzo D, Dastgir J, Marshall JL, Lek M, MacArthur DG, Reghan Foley A, Bönnemann CG. Identification of a Novel Deep Intronic Mutation in CAPN3 Presenting a Promising Target for Therapeutic Splice Modulation. J Neuromuscul Dis. 2019 Aug 31. doi: 10.3233/JND-190414. [Epub ahead of print].

Nucleoporin 62-Like Protein is Required for the Development of Pharyngeal Arches through Regulation of Wnt/β-Catenin Signaling and Apoptotic Homeostasis in Zebrafish

Authors:
Yang X, Li X, Gu Q, Li Q, Cui Z
Citation:
Cells. 2019;8(9):1038. doi:10.3390/cells8091038
Abstract:
We have previously observed the predominant expression of nucleoporin 62-like (Nup62l) mRNA in the pharyngeal region of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang X, Li X, Gu Q, Li Q, Cui Z. Nucleoporin 62-Like Protein is Required for the Development of Pharyngeal Arches through Regulation of Wnt/β-Catenin Signaling and Apoptotic Homeostasis in Zebrafish. Cells. 2019;8(9):1038. doi:10.3390/cells8091038.

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