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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10798 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Targeted SMN Exon Skipping: A Useful Control to Assess In Vitro and In Vivo Splice-Switching Studies

Authors:
Flynn LL, Mitrpant C, Adams A, Pitout IL, Stirnweiss A, Fletcher S, Wilton SD
Citation:
Biomedicines. 2021;9(5):552. doi:10.3390/biomedicines9050552
Epub:
Not Epub
Abstract:
The literature surrounding the use of antisense oligonucleotides continues to grow, with new disease and mechanistic...
Delivery Method:
cell bathing, injection subcutaneous and intraperitoneal (s.c. & i.p.)
Organism or Cell Type:
cell culture: human fibroblasts, SH-SY5Y neuroblastoma, mdx myoblasts; mice
Citation Extract:
Flynn LL, Mitrpant C, Adams A, Pitout IL, Stirnweiss A, Fletcher S, Wilton SD. Targeted SMN Exon Skipping: A Useful Control to Assess In Vitro and In Vivo Splice-Switching Studies. Biomedicines. 2021;9(5):552. doi:10.3390/biomedicines9050552.

Insm1-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis

Authors:
Tournière O, Busengdal H, Gahan JM, Rentzsch F
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439178
Epub:
Not Epub
Abstract:
Neurons are highly specialized cells present in nearly all animals, but their evolutionary origin and relationship to other...
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (cniderian)
Citation Extract:
Tournière O, Busengdal H, Gahan JM, Rentzsch F. Insm1-expressing neurons and secretory cells develop from a common pool of progenitors in the sea anemone Nematostella vectensis. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439178.

Myeloid and endothelial cells cooperate to promote hematopoietic stem cells expansion in the fetal niche

Authors:
Cacialli P, Mailhe M-P, Golub R, Bertrand JY
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.07.438809
Epub:
Not Epub
Abstract:
During embryonic development, very few hematopoietic stem cells (HSCs) are produced from the hemogenic endothelium, that will...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cacialli P, Mailhe M-P, Golub R, Bertrand JY. Myeloid and endothelial cells cooperate to promote hematopoietic stem cells expansion in the fetal niche. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.07.438809.

Surrogate production of genome edited sperm from a different subfamily by spermatogonial stem cell transplantation

Authors:
Zhang F, Li X, Hao Y, Li Y, Ye D, He M, Wang H, Zhu Z, Sun Y
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.20.440715
Epub:
Not Epub
Abstract:
The surrogate reproduction technique provides a powerful tool for production of allogenic or xenogeneic gametes derived from...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang F, Li X, Hao Y, Li Y, Ye D, He M, Wang H, Zhu Z, Sun Y. Surrogate production of genome edited sperm from a different subfamily by spermatogonial stem cell transplantation. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.20.440715.

TBX5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development

Authors:
Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AM
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439219
Epub:
Not Epub
Abstract:
The gene regulatory networks that coordinate the development of the cardiac and pulmonary systems are essential for terrestrial...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis
Citation Extract:
Rankin SA, Steimle JD, Yang XH, Rydeen AB, Agarwal K, Chaturvedi P, Ikegami K, Herriges MJ, Moskowitz IP, Zorn AM. TBX5 drives Aldh1a2 expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.09.439219.

Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis

Authors:
Zheng L, Liu Z, Wang Y, Yang F, Wang J, Huang W, Qin J, Tian M, Cai X, Liu X, Mo X, Gao N, Jia D
Citation:
Nat Struct Mol Biol. 2021;28(5):1–12. doi:10.1038/s41594-021-00591-9
Epub:
Not Epub
Abstract:
GDP-mannose (GDP-Man) is a key metabolite essential for protein glycosylation and glycophosphatidylinositol anchor synthesis,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zheng L, Liu Z, Wang Y, Yang F, Wang J, Huang W, Qin J, Tian M, Cai X, Liu X, Mo X, Gao N, Jia D. Cryo-EM structures of human GMPPA–GMPPB complex reveal how cells maintain GDP-mannose homeostasis. Nat Struct Mol Biol. 2021;28(5):1–12. doi:10.1038/s41594-021-00591-9.

A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements

Authors:
Fish L, Khoroshkin M, Navickas A, Garcia K, Culbertson B, Hänisch B, Zhang S, Nguyen CB, Soto LM, Dermit M, Mardakheh FK, Molina H, Alarcón C, Najafabadi HS, Goodarzi H
Citation:
Science. 2021;372(6543): doi:10.1126/science.abc7531
Epub:
Not Epub
Abstract:
Aberrant alternative splicing is a hallmark of cancer, yet the underlying regulatory programs that control this process remain...
Delivery Method:
Endo-Porter
Organism or Cell Type:
Cell culture: HCC1806-LM2 , MDA-LM2
Citation Extract:
Fish L, Khoroshkin M, Navickas A, Garcia K, Culbertson B, Hänisch B, Zhang S, Nguyen CB, Soto LM, Dermit M, Mardakheh FK, Molina H, Alarcón C, Najafabadi HS, Goodarzi H. A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements. Science. 2021;372(6543): doi:10.1126/science.abc7531.

Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis

Authors:
Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI
Citation:
Science. 2021;372(6543):716-21. doi:10.1126/science.aaz2740
Epub:
Not Epub
Abstract:
Transcription and metabolism both influence cell function, but dedicated transcriptional control of metabolic pathways that...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rossmann MP, Hoi K, Chan V, Abraham BJ, Yang S, Mullahoo J, Papanastasiou M, Wang Y, Elia I, Perlin JR, Hagedorn EJ, Hetzel S, Weigert R, Vyas S, Nag PP, Sullivan LB, Warren CR, Dorjsuren B, Greig EC, Adatto I, Cowan CA, Schreiber SL, Young RA, Meissner A, Haigis MC, Hekimi S, Carr SA, Zon LI. Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science. 2021;372(6543):716-21. doi:10.1126/science.aaz2740.

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

Authors:
Bresciani E, Carrington B, Yu K, Kim EM, Zhen T, Guzman VS, Broadbridge E, Bishop K, Kirby M, Harper U, Wincovitch S, Dell’Orso S, Sartorelli V, Sood R, Liu P
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.02.438148
Epub:
Not Epub
Abstract:
RUNX1 is essential for the generation of hematopoietic stem cells (HSCs). Runx1 null mouse embryos lack definitive...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Bresciani E, Carrington B, Yu K, Kim EM, Zhen T, Guzman VS, Broadbridge E, Bishop K, Kirby M, Harper U, Wincovitch S, Dell’Orso S, Sartorelli V, Sood R, Liu P. Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.02.438148 .

Maternal and zygotic factors sequentially shape the tissue regionalization of chromatin landscapes in early vertebrate embryos

Authors:
Paraiso KD, Blitz IL, Cho KWY
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.04.14.439777
Epub:
Not Epub
Abstract:
One of the first steps in cellular differentiation of vertebrate embryos is the formation of the three germ layers. Maternal...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Paraiso KD, Blitz IL, Cho KWY. Maternal and zygotic factors sequentially shape the tissue regionalization of chromatin landscapes in early vertebrate embryos. bioRxiv. 2021;[preprint] doi:10.1101/2021.04.14.439777.

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