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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11377 scientific papers returned from the database with the search filters currently being used below.

Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development

Authors:
Xu W, Nelson-Maney NP, Bálint L, Kwon HB, Davis RB, Dy DCM, Dunleavey JM, St Croix B, Caron KM
Citation:
Int J Mol Sci. 2022 May 20;23(10):5712. doi: 10.3390/ijms23105712
Epub:
Not Epub
Abstract:
Numerous studies have focused on the molecular signaling pathways that govern the development and growth of lymphatics in the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xu W, Nelson-Maney NP, Bálint L, Kwon HB, Davis RB, Dy DCM, Dunleavey JM, St Croix B, Caron KM. Orphan G-Protein Coupled Receptor GPRC5B Is Critical for Lymphatic Development. Int J Mol Sci. 2022 May 20;23(10):5712. doi: 10.3390/ijms23105712.

U1 snRNP regulates early spliceosome assembly by disrupting the interaction between SR proteins and the pre-mRNA

Authors:
Saha K, Ghosh G
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.12.01.470860
Epub:
Not Epub
Abstract:
The pre-mRNA features that define the splice signals at or near exon-intron junctions for assembly of the early spliceosome are...
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Saha K, Ghosh G. U1 snRNP regulates early spliceosome assembly by disrupting the interaction between SR proteins and the pre-mRNA. bioRxiv. 2021;[preprint] doi:10.1101/2021.12.01.470860.

Transcription factors that specify cell fate activate cell cycle regulator genes to determine cell numbers in ascidian larval tissues

Authors:
Kobayashi K, Tokuoka M, Sato H, Ariyoshi M, Kawahara S, Fujiwara S, Kishimoto T, Satou Y
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.05.16.492211
Epub:
Not Epub
Abstract:
In animal development, most cell types stop dividing before terminal differentiation; thus, cell cycle control is tightly...
Delivery Method:
microinjection
Organism or Cell Type:
Ciona savignyi (ascidian)
Citation Extract:
Kobayashi K, Tokuoka M, Sato H, Ariyoshi M, Kawahara S, Fujiwara S, Kishimoto T, Satou Y. Transcription factors that specify cell fate activate cell cycle regulator genes to determine cell numbers in ascidian larval tissues. bioRxiv. 2022;[preprint] doi:10.1101/2022.05.16.492211 .

RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer

Authors:
Hall AE, Pohl SÖ, Cammareri P, Aitken S, Younger NT, Raponi M, Billard CV, Carrancio AB, Bastem A, Freile P, Haward F, Adams IR, Caceres JF, Preyzner P, von Kriegsheim A, Dunlop MG, Din FV, Myant KB
Citation:
Nat Commun. 2022 May 19;13(1):2791. doi: 10.1038/s41467-022-30489-z
Epub:
Not Epub
Abstract:
Tumour cell plasticity is a major barrier to the efficacy of targeted cancer therapies but the mechanisms that mediate it are...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mouse intestine cells
Citation Extract:
Hall AE, Pohl SÖ, Cammareri P, Aitken S, Younger NT, Raponi M, Billard CV, Carrancio AB, Bastem A, Freile P, Haward F, Adams IR, Caceres JF, Preyzner P, von Kriegsheim A, Dunlop MG, Din FV, Myant KB. RNA splicing is a key mediator of tumour cell plasticity and a therapeutic vulnerability in colorectal cancer. Nat Commun. 2022 May 19;13(1):2791. doi: 10.1038/s41467-022-30489-z.

Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character

Authors:
Powell GT, Zhao Y, Faro A, Stickney H, Novellasdemunt L, Henriques P, Gestri G, White ER, Ren J, Lu W, Young RM, Hawkins TA, Cavodeassi F, Schwarz Q, Dreosti E, Raible DW, Li VSW, Wright GJ, Jones EY, Wilson SW
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.05.16.492129
Epub:
Not Epub
Abstract:
Neurons on left and right sides of the nervous system frequently show asymmetric properties but how these differences arise is...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Powell GT, Zhao Y, Faro A, Stickney H, Novellasdemunt L, Henriques P, Gestri G, White ER, Ren J, Lu W, Young RM, Hawkins TA, Cavodeassi F, Schwarz Q, Dreosti E, Raible DW, Li VSW, Wright GJ, Jones EY, Wilson SW. Cachd1 is a novel Frizzled- and LRP6-interacting protein required for neurons to acquire left-right asymmetric character. bioRxiv. 2022;[preprint] doi:10.1101/2022.05.16.492129 .

Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration into the brain disrupting daytime locomotion

Authors:
Kwon V, Cai P, Dixon CT, Hamlin V, Spencer CG, Rojas AM, Hamilton M, Shiau CE
Citation:
Commun Biol. 2022 May 16;5(1):464. doi: 10.1038/s42003-022-03410-z
Epub:
Not Epub
Abstract:
Inflammation is known to disrupt normal behavior, yet the underlying neuroimmune interactions remain elusive. Here, we...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Kwon V, Cai P, Dixon CT, Hamlin V, Spencer CG, Rojas AM, Hamilton M, Shiau CE. Peripheral NOD-like receptor deficient inflammatory macrophages trigger neutrophil infiltration into the brain disrupting daytime locomotion. Commun Biol. 2022 May 16;5(1):464. doi: 10.1038/s42003-022-03410-z.

The Cytoskeletal Protein Zyxin Inhibits Retinoic Acid Signaling by Destabilizing the Maternal mRNA of the RXRγ Nuclear Receptor

Authors:
Parshina EA, Orlov EE, Zaraisky AG, Martynova NY
Citation:
Inter J Mol Sci. 2022;23(10):5627. doi:10.3390/ijms23105627
Epub:
Not Epub
Abstract:
Zyxin is an LIM-domain-containing protein that regulates the assembly of F-actin filaments in cell contacts. Additionally, as a...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Parshina EA, Orlov EE, Zaraisky AG, Martynova NY. The Cytoskeletal Protein Zyxin Inhibits Retinoic Acid Signaling by Destabilizing the Maternal mRNA of the RXRγ Nuclear Receptor. Inter J Mol Sci. 2022;23(10):5627. doi:10.3390/ijms23105627.

BDNF signaling in Hebbian and Stentian structural plasticity in the developing visual system

Authors:
Kutsarova E, Schohl A, Munz M, Wang A, Zhang YY, Bilash OM, Ruthazer ES
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.10.07.463583
Epub:
Not Epub
Abstract:
During development, patterned neural activity instructs topographic map refinement. Axons with similar patterns of neural...
Delivery Method:
ocular injection then electroporation
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kutsarova E, Schohl A, Munz M, Wang A, Zhang YY, Bilash OM, Ruthazer ES. BDNF signaling in Hebbian and Stentian structural plasticity in the developing visual system. bioRxiv. 2021;[preprint] doi:10.1101/2021.10.07.463583 .

Transmembrane Protein 184A and Syndecan-4 function in the same pathway to promote angiogenesis

Authors:
Altenburg LM, O'Toole RA, Ciabattoni GO, Papov IV, Pasch LM, Maslonka BE, Lowe-Krentz LJ
Citation:
FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.L8077
Epub:
Not Epub
Abstract:
Morpholino (MO) knockdown (KD) of the novel vascular heparin receptor, Transmembrane protein 184A (TMEM184A), increases...
Delivery Method:
injection
Organism or Cell Type:
zebrafish
Citation Extract:
Altenburg LM, O'Toole RA, Ciabattoni GO, Papov IV, Pasch LM, Maslonka BE, Lowe-Krentz LJ. Transmembrane Protein 184A and Syndecan-4 function in the same pathway to promote angiogenesis. FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.L8077.

microRNA-34a modulates the senescence of activated hepatic stellate cells in alcohol-associated liver injury

Authors:
Slevin E, Wan Y, Harrison K, Zhang Y, Li X, Li T, Lorenzo SR, Xu W, Klaunig JE, Shetty AK, Meng F
Citation:
FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.R4231
Epub:
Not Epub
Abstract:
Background: Reversion of activated hepatic stellate cells (HSCs) to quiescence is likely to be a promising pathway in liver...
Organism or Cell Type:
mice
Citation Extract:
Slevin E, Wan Y, Harrison K, Zhang Y, Li X, Li T, Lorenzo SR, Xu W, Klaunig JE, Shetty AK, Meng F. microRNA-34a modulates the senescence of activated hepatic stellate cells in alcohol-associated liver injury. FASEB J. 2022;[Epub] doi:10.1096/fasebj.2022.36.S1.R4231.

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