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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10468 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification

Authors:
Hutchins EJ, Chacon J, Bronner ME
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.10.14.338715
Abstract:
Neural crest development is transcriptionally controlled via sequential activation of gene regulatory networks (GRNs). Recent...
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Hutchins EJ, Chacon J, Bronner ME. RNA-binding protein Elavl1/HuR is required for maintenance of cranial neural crest specification. bioRxiv. 2020;[preprint] doi:10.1101/2020.10.14.338715 .

hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development

Authors:
Ye Z, Kimelman D
Citation:
Development. 2020;[Epub ahead of print] doi:10.1242/dev.185298
Abstract:
The early vertebrate embryo extends from anterior to posterior due to the addition of neural and mesodermal cells from a...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ye Z, Kimelman D. hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development. Development. 2020;[Epub ahead of print] doi:10.1242/dev.185298.

Traditional African remedies induce hemolysis in a glucose-6-phopshate dehydrogenase deficient zebrafish model

Authors:
Arogbokun O, Shevik M, Slusher T, Farouk Z, Elfstrum A, Weber J, Cusick SE, Lund T
Citation:
Sci Rep. 2020;10(1):19172 doi:10.1038/s41598-020-75823-x
Abstract:
Traditional remedies are widely used throughout Africa in routine care for infants. However, such remedies could have...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Arogbokun O, Shevik M, Slusher T, Farouk Z, Elfstrum A, Weber J, Cusick SE, Lund T. Traditional African remedies induce hemolysis in a glucose-6-phopshate dehydrogenase deficient zebrafish model. Sci Rep. 2020;10(1):19172 doi:10.1038/s41598-020-75823-x.

A serpin is required for ectomesoderm, a hallmark of spiralian development

Authors:
Wu L, Lambert JD
Citation:
Dev Biol. 2020 Oct 24:S0012-1606(20)30282-7. doi: 10.1016/j.ydbio.2020.10.011. Online ahead of print
Abstract:
Among animals, diploblasts contain two germ layers, endoderm and ectoderm, while triploblasts have a distinct third germ layer...
Delivery Method:
microinjection
Organism or Cell Type:
Tritia obsoleta (previously Ilyanassa obsoleta) gastropod
Citation Extract:
Wu L, Lambert JD. A serpin is required for ectomesoderm, a hallmark of spiralian development. Dev Biol. 2020 Oct 24:S0012-1606(20)30282-7. doi: 10.1016/j.ydbio.2020.10.011. Online ahead of print.

R-spondins are BMP receptor antagonists in Xenopus early embryonic development

Authors:
Lee H, Seidl C, Sun R, Glinka A, Niehrs C
Citation:
Nat Commun. 2020;11:5570. doi:10.1038/s41467-020-19373-w
Abstract:
BMP signaling plays key roles in development, stem cells, adult tissue homeostasis, and disease. How BMP receptors are...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Lee H, Seidl C, Sun R, Glinka A, Niehrs C. R-spondins are BMP receptor antagonists in Xenopus early embryonic development. Nat Commun. 2020;11:5570. doi:10.1038/s41467-020-19373-w.

Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency

Authors:
Diofano F, Weinmann K, Schneider I, Thiessen KD, Rottbauer W, Just S
Citation:
PLoS Genet. 2020 Nov 2;16(11):e1009088. doi: 10.1371/journal.pgen.1009088. eCollection 2020 Nov
Abstract:
Mutations in the molecular co-chaperone Bcl2-associated athanogene 3 (BAG3) are found to cause dilated cardiomyopathy (DCM),...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Diofano F, Weinmann K, Schneider I, Thiessen KD, Rottbauer W, Just S. Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency. PLoS Genet. 2020 Nov 2;16(11):e1009088. doi: 10.1371/journal.pgen.1009088. eCollection 2020 Nov.

TGS1 controls snRNA 3’ end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo

Authors:
Chen L, Roake CM, Maccallini P, Bavasso F, Dehghannasiri R, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzuti L, Esposito A, Gallotta I, Francia S, Cacchione S, Hammerschmidt M, De Pittà C, Gabriele Sales G, Salzman J, Pellizzoni L, Wirth B, Di Schiavi E, Gatti M, Artandi SE, Raffa GD
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.10.27.356782
Abstract:
Trimethylguanosine synthase 1 (TGS1) is a highly conserved enzyme that converts the 5’ mono-methylguanosine cap of snRNAs to a...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen L, Roake CM, Maccallini P, Bavasso F, Dehghannasiri R, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzuti L, Esposito A, Gallotta I, Francia S, Cacchione S, Hammerschmidt M, De Pittà C, Gabriele Sales G, Salzman J, Pellizzoni L, Wirth B, Di Schiavi E, Gatti M, Artandi SE, Raffa GD. TGS1 controls snRNA 3’ end processing, prevents neurodegeneration and ameliorates SMN-dependent neurological phenotypes in vivo. bioRxiv. 2020;[preprint] doi:10.1101/2020.10.27.356782.

Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification

Authors:
Reis AH, Sokol SY
Citation:
bioRxiv. 2020;[preprint] doi:/10.1101/2020.10.30.362541
Abstract:
The Wnt pathway activates target genes by controlling the b-catenin-T-cell factor (TCF) transcriptional complex during...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Reis AH, Sokol SY. Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification. bioRxiv. 2020;[preprint] doi:/10.1101/2020.10.30.362541 .

Uncovering the mesendoderm gene regulatory network through multi-omic data integration

Authors:
Jansen C, Paraiso K, Zhou J, Blitz IL, Fish M, Charney R, Cho JS, Yasuoka Y, Sudou N, Bright AR, Wlizla M, Veenstra GJC, Taira M, Zorn A, Mortazavi A, Cho KWY
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.11.01.362053
Abstract:
Mesendodermal specification is one of the earliest events in embryogenesis, where cells first acquire distinct identities. Cell...
Organism or Cell Type:
Xenopus
Citation Extract:
Jansen C, Paraiso K, Zhou J, Blitz IL, Fish M, Charney R, Cho JS, Yasuoka Y, Sudou N, Bright AR, Wlizla M, Veenstra GJC, Taira M, Zorn A, Mortazavi A, Cho KWY. Uncovering the mesendoderm gene regulatory network through multi-omic data integration. bioRxiv. 2020;[preprint] doi:10.1101/2020.11.01.362053.

Prostasin and hepatocyte growth factor B in factor VIIa generation: Serine protease knockdowns in zebrafish

Authors:
Khandekar G, Iyer N, Jagadeeswaran P
Citation:
Res Pract Thromb Haemost. 2020 Sep 22;4(7):1150-1157. doi: 10.1002/rth2.12428. eCollection 2020 Oct
Abstract:
Background: Blood clotting in humans is initiated by the binding of tissue factor to activated coagulation factor VII (FVIIa)...
Delivery Method:
Vivo-Morpholino (piggyback)
Organism or Cell Type:
zebrafish
Citation Extract:
Khandekar G, Iyer N, Jagadeeswaran P. Prostasin and hepatocyte growth factor B in factor VIIa generation: Serine protease knockdowns in zebrafish. Res Pract Thromb Haemost. 2020 Sep 22;4(7):1150-1157. doi: 10.1002/rth2.12428. eCollection 2020 Oct.

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