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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11141 scientific papers returned from the database with the search filters currently being used below.

Slit-Robo Signalling Establishes a Sphingosine-1-Phosphate Gradient to Polarise Fin Mesenchyme and Establish Fin Morphology

Authors:
Mahabaleshwar H, Asharani PV, Loo TYJ, Koh SY, Pitman MR, Kwok S, Ma J, Hu B, Lin F, Lok XL, Pitson SM, Saunders TE, Carney TJ
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.12.07.471519
Epub:
Not Epub
Abstract:
Immigration of mesenchymal cells into the growing fin and limb buds drives distal outgrowth, with subsequent tensile forces...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mahabaleshwar H, Asharani PV, Loo TYJ, Koh SY, Pitman MR, Kwok S, Ma J, Hu B, Lin F, Lok XL, Pitson SM, Saunders TE, Carney TJ. Slit-Robo Signalling Establishes a Sphingosine-1-Phosphate Gradient to Polarise Fin Mesenchyme and Establish Fin Morphology. bioRxiv. 2021;[preprint] doi:10.1101/2021.12.07.471519.

Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice

Authors:
Kenjo E, Hozumi H, Makita Y, Iwabuchi KA, Fujimoto N, Matsumoto S, Kimura M, Amano Y, Ifuku M, Naoe Y, Inukai N, Hotta A
Citation:
Nat Commun. 2021;12(1):7101. doi:10.1038/s41467-021-26714-w
Epub:
Not Epub
Abstract:
Genome editing therapy for Duchenne muscular dystrophy (DMD) holds great promise, however, one major obstacle is delivery of...
Delivery Method:
i.m. injection
Organism or Cell Type:
mice
Citation Extract:
Kenjo E, Hozumi H, Makita Y, Iwabuchi KA, Fujimoto N, Matsumoto S, Kimura M, Amano Y, Ifuku M, Naoe Y, Inukai N, Hotta A. Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice. Nat Commun. 2021;12(1):7101. doi:10.1038/s41467-021-26714-w.

Collective durotaxis along a self-generated stiffness gradient in vivo

Authors:
Shellard A, Mayor R
Citation:
Nature. 2021;[Epub ahead of print]. doi:10.1038/s41586-021-04210-x
Epub:
Not Epub
Abstract:
Collective cell migration underlies morphogenesis, wound healing and cancer invasion. Most directed migration in vivo has been...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Shellard A, Mayor R. Collective durotaxis along a self-generated stiffness gradient in vivo. Nature. 2021;[Epub ahead of print]. doi:10.1038/s41586-021-04210-x.

Mechanisms underlying microglial colonization of developing neural retina in zebrafish

Authors:
Ranawat N, Masai I
Citation:
eLife. 2021;10:e70550. doi:10.7554/eLife.70550
Epub:
Not Epub
Abstract:
Microglia are brain-resident macrophages that function as the first line of defense in brain. Embryonic microglial precursors...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ranawat N, Masai I. Mechanisms underlying microglial colonization of developing neural retina in zebrafish. eLife. 2021;10:e70550. doi:10.7554/eLife.70550.

Restoration of Normal NF1 Function with Antisense Morpholino Treatment of Recurrent Pathogenic Patient-Specific Variant c.1466A>G; p.Y489C

Authors:
Awad EK, Moore M, Liu H, Ciszewski L, Lambert L, Korf BR, Popplewell L, Kesterson RA, Wallis D
Citation:
J Pers Med 2021;11(12):1320. doi:10.3390/jpm11121320
Epub:
Not Epub
Abstract:
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder with almost 3000 different disease-causing variants...
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human PGP1 iPSC
Citation Extract:
Awad EK, Moore M, Liu H, Ciszewski L, Lambert L, Korf BR, Popplewell L, Kesterson RA, Wallis D. Restoration of Normal NF1 Function with Antisense Morpholino Treatment of Recurrent Pathogenic Patient-Specific Variant c.1466A>G; p.Y489C. J Pers Med 2021;11(12):1320. doi:10.3390/jpm11121320.

Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX

Authors:
Ma J, Scott CA, Ho YN, Mahabaleshwar H, Marsay KS, Zhang C, Teow CKJ, Ng SS, Zhang W
Citation:
eLife 2021;10:e66596 doi: 10.7554/eLife.66596
Epub:
Not Epub
Abstract:
Epithelial tissues are primed to respond to insults by activating epithelial cell motility and rapid inflammation. Such...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ma J, Scott CA, Ho YN, Mahabaleshwar H, Marsay KS, Zhang C, Teow CKJ, Ng SS, Zhang W. Matriptase activation of Gq drives epithelial disruption and inflammation via RSK and DUOX. eLife 2021;10:e66596 doi: 10.7554/eLife.66596.

Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation

Authors:
Arand J, Chiang HR, Martin D, Snyder MP, Sage J, Reijo Pera RA, Wossidlo M
Citation:
EMBO Rep. 2021 Dec 6:e53968. doi: 10.15252/embr.202153968. Online ahead of print
Epub:
Not Epub
Abstract:
Mammalian development begins in transcriptional silence followed by a period of widespread activation of thousands of genes....
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Arand J, Chiang HR, Martin D, Snyder MP, Sage J, Reijo Pera RA, Wossidlo M. Tet enzymes are essential for early embryogenesis and completion of embryonic genome activation. EMBO Rep. 2021 Dec 6:e53968. doi: 10.15252/embr.202153968. Online ahead of print.

Evaluation of endogenous miRNA reference genes across different zebrafish strains, developmental stages and kidney disease models

Authors:
Siegerist F, Lange T, Iervolino A, Koppe TM, Zhou W, Capasso G, Endlich K, Endlich N
Citation:
Sci Rep. 2021;11(1):22894. doi:10.1038/s41598-021-00075-2
Epub:
Not Epub
Abstract:
The majority of kidney diseases arise from the loss of podocytes and from morphological changes of their highly complex foot...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Siegerist F, Lange T, Iervolino A, Koppe TM, Zhou W, Capasso G, Endlich K, Endlich N. Evaluation of endogenous miRNA reference genes across different zebrafish strains, developmental stages and kidney disease models. Sci Rep. 2021;11(1):22894. doi:10.1038/s41598-021-00075-2.

RGS2 Suppresses Melanoma Growth via Inhibiting MAPK and AKT Signaling Pathways

Authors:
Lin SJ, Huang YC, Chen HY, Fang JY, Hsu SY, Shih HY, Liu YC, Cheng YC
Citation:
Anticancer Res. 2021 Dec;41(12):6135-6145. doi: 10.21873/anticanres.15433
Epub:
Not Epub
Abstract:
Background/Aim: This study aimed to explore RGS2 as a regulator of melanoma cell growth. Materials and Methods: Effect of RGS2...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lin SJ, Huang YC, Chen HY, Fang JY, Hsu SY, Shih HY, Liu YC, Cheng YC. RGS2 Suppresses Melanoma Growth via Inhibiting MAPK and AKT Signaling Pathways. Anticancer Res. 2021 Dec;41(12):6135-6145. doi: 10.21873/anticanres.15433.

A Dystrophin Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping

Authors:
Echigoya Y, Trieu N, Duddy W, Moulton HM, Yin H, Partridge TA, Hoffman EP, Kornegay JN, Rohret FA, Rogers CS, Yokota T
Citation:
Int J Mol Sci. 2021;22(23):13065. doi:10.3390/ijms222313065
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a lethal X-linked recessive disorder caused by mutations in the DMD gene and the...
Delivery Method:
peptide-linked, Endo-Porter
Organism or Cell Type:
Sus scrofa domestica (pig)
Citation Extract:
Echigoya Y, Trieu N, Duddy W, Moulton HM, Yin H, Partridge TA, Hoffman EP, Kornegay JN, Rohret FA, Rogers CS, Yokota T. A Dystrophin Exon-52 Deleted Miniature Pig Model of Duchenne Muscular Dystrophy and Evaluation of Exon Skipping. Int J Mol Sci. 2021;22(23):13065. doi:10.3390/ijms222313065 .

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