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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9646 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal

Authors:
Di Bella DJ, Carcagno AL, Bartolomeu ML, Pardi MB, Löhr H, Siegel N, Hammerschmidt M, Marín-Burgin A, Lanuza GM
Citation:
Cell Rep. 2019;28(9):2264-74. doi:10.1016/j.celrep.2019.07.087
Abstract:
Generation of neuronal types at the right time, location, and number is essential for building a functional nervous system....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Di Bella DJ, Carcagno AL, Bartolomeu ML, Pardi MB, Löhr H, Siegel N, Hammerschmidt M, Marín-Burgin A, Lanuza GM. Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal. Cell Rep. 2019;28(9):2264-74. doi:10.1016/j.celrep.2019.07.087.

Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy

Authors:
Fadzen CM, Holden R, Wolfe JM, Choo Z-N, Schissel CK, Yao M, Hanson GJ, Pentelute BL
Citation:
Biochemistry. 2019;[Epub ahead of print] doi:10.1021/acs.biochem.9b00413
Abstract:
Phosphorodiamidate morpholino oligonucleotides (PMOs) are a promising class of therapeutics for genetic disease. PMOs designed...
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: HeLa-654
Citation Extract:
Fadzen CM, Holden R, Wolfe JM, Choo Z-N, Schissel CK, Yao M, Hanson GJ, Pentelute BL. Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy. Biochemistry. 2019;[Epub ahead of print] doi:10.1021/acs.biochem.9b00413.

Transcriptional autoregulation of zebrafish tbx6 is required for somite segmentation

Authors:
Ban H, Yokota D, Otosaka S, Kikuchi M, Kinoshita H, Fujino Y, Yabe T, Ovara H, Izuka A, Akama K, Yamasu K, Takada S, Kawamura A.
Citation:
Development. 2019 Aug 23. pii: dev.177063. doi: 10.1242/dev.177063. [Epub ahead of print]
Abstract:
The presumptive somite boundary in the presomitic mesoderm (PSM) is defined by the anterior border of the expression domain of...
Organism or Cell Type:
zebrafish
Citation Extract:
Ban H, Yokota D, Otosaka S, Kikuchi M, Kinoshita H, Fujino Y, Yabe T, Ovara H, Izuka A, Akama K, Yamasu K, Takada S, Kawamura A.. Transcriptional autoregulation of zebrafish tbx6 is required for somite segmentation. Development. 2019 Aug 23. pii: dev.177063. doi: 10.1242/dev.177063. [Epub ahead of print].

A conserved regulatory program initiates lateral plate mesoderm emergence across chordates

Authors:
Prummel KD, Hess C, Nieuwenhuize S, Parker HJ, Rogers KW, Kozmikova I, Racioppi C, Brombacher EC, Anna Czarkwiani, Knapp D, Burger S, Chiavacci E, Shah G, Burger A, Huisken J, Yun MH, Christiaen L, Kozmik Z, Müller P, Bronner M, Krumlauf R, Mosimann C
Citation:
Nat Comm. 2019;10(1):3857. doi:10.1038/s41467-019-11561-7
Abstract:
Cardiovascular lineages develop together with kidney, smooth muscle, and limb connective tissue progenitors from the lateral...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Prummel KD, Hess C, Nieuwenhuize S, Parker HJ, Rogers KW, Kozmikova I, Racioppi C, Brombacher EC, Anna Czarkwiani, Knapp D, Burger S, Chiavacci E, Shah G, Burger A, Huisken J, Yun MH, Christiaen L, Kozmik Z, Müller P, Bronner M, Krumlauf R, Mosimann C. A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nat Comm. 2019;10(1):3857. doi:10.1038/s41467-019-11561-7.

Microsyntenic Clusters Reveal Conservation of lncRNAs in Chordates Despite Absence of Sequence Conservation

Authors:
Herrera-Úbeda C, Marín-Barba M, Navas-Pérez E, Gravemeyer J, Albuixech-Crespo BA, Wheeler GN, Garcia-Fernàndez J
Citation:
Biology. 2019;8(3):61. doi:10.3390/biology8030061
Abstract:
Homologous long non-coding RNAs (lncRNAs) are elusive to identify by sequence similarity due to their fast-evolutionary rate....
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Herrera-Úbeda C, Marín-Barba M, Navas-Pérez E, Gravemeyer J, Albuixech-Crespo BA, Wheeler GN, Garcia-Fernàndez J. Microsyntenic Clusters Reveal Conservation of lncRNAs in Chordates Despite Absence of Sequence Conservation. Biology. 2019;8(3):61. doi:10.3390/biology8030061.

Functional role of pax6 during eye and nervous system development in the annelid Capitella teleta

Authors:
Klann M, Seaver EC
Citation:
Dev Biol. 2019 Aug 21. pii: S0012-1606(18)30055-1. doi: 10.1016/j.ydbio.2019.08.011. [Epub ahead of print]
Abstract:
The transcription factor Pax6 is an important regulator of early animal development. Loss of function mutations of pax6 in a...
Delivery Method:
microinjection
Organism or Cell Type:
Capitella teleta (annelid)
Citation Extract:
Klann M, Seaver EC. Functional role of pax6 during eye and nervous system development in the annelid Capitella teleta. Dev Biol. 2019 Aug 21. pii: S0012-1606(18)30055-1. doi: 10.1016/j.ydbio.2019.08.011. [Epub ahead of print].

Failure to clear developmental apoptosis contributes to the pathology of RNASET2-deficient leukoencephalopathy

Authors:
Hamilton N, Rutherford HA, Isles HM, Petts JJ, Henneke M, Gaertner J, Dunning M, Renshaw SA
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/744144
Abstract:
The contribution of microglia in neurological disorders is emerging as a leading driver rather than a consequence of pathology...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hamilton N, Rutherford HA, Isles HM, Petts JJ, Henneke M, Gaertner J, Dunning M, Renshaw SA. Failure to clear developmental apoptosis contributes to the pathology of RNASET2-deficient leukoencephalopathy. bioRxiv. 2019;[preprint] doi:10.1101/744144.

Chemokine signaling links cell-cycle progression and cilia formation for left–right symmetry breaking

Authors:
Liu J, Zhu C, Ning G, Yang L, Cao Y, Huang S, Wang Q
Citation:
PLoS Biol. 2019;17(8):e3000203. doi:10.1371/journal.pbio.3000203
Abstract:
Zebrafish dorsal forerunner cells (DFCs) undergo vigorous proliferation during epiboly and then exit the cell cycle to generate...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu J, Zhu C, Ning G, Yang L, Cao Y, Huang S, Wang Q. Chemokine signaling links cell-cycle progression and cilia formation for left–right symmetry breaking. PLoS Biol. 2019;17(8):e3000203. doi:10.1371/journal.pbio.3000203.

Genome-wide identification of binding sites and gene targets of Alx1, a pivotal regulator of echinoderm skeletogenesis

Authors:
Khor JM, Guerrero-Santoro J, Ettensohn CA
Citation:
Development. 2019;146:dev180653. doi: 10.1242/dev.180653
Abstract:
Alx1 is a conserved regulator of skeletogenesis in echinoderms and evolutionary changes in Alx1 sequence and expression have...
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Khor JM, Guerrero-Santoro J, Ettensohn CA. Genome-wide identification of binding sites and gene targets of Alx1, a pivotal regulator of echinoderm skeletogenesis. Development. 2019;146:dev180653. doi: 10.1242/dev.180653.

Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins

Authors:
Poon J, Fries A, Wessel GM, Yajima M
Citation:
Nat Comm. 2019;10(1):3779. doi:10.1038/s41467-019-11560-8
Abstract:
Evolution is proposed to result, in part, from acquisition of new developmental programs. One such example is the appearance of...
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin)
Citation Extract:
Poon J, Fries A, Wessel GM, Yajima M. Evolutionary modification of AGS protein contributes to formation of micromeres in sea urchins. Nat Comm. 2019;10(1):3779. doi:10.1038/s41467-019-11560-8.

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