You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9320 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance

Authors:
Bustamante-Marin XM, Yin WN, Sears PR, Werner ME, Brotslaw EJ, Mitchell BJ, Jania CM, Zeman KL, Rogers TD, Herring LE, Refabért L, Thomas L, Amselem S, Escudier E, Legendre M, Grubb BR, Knowles MR, Zariwala MA, Ostrowski LE
Citation:
Am J Hum Genet. 2019 Jan 18. pii: S0002-9297(18)30460-9. doi: 10.1016/j.ajhg.2018.12.009. [Epub ahead of print]
Abstract:
Primary ciliary dyskinesia (PCD) is a genetic disorder in which impaired ciliary function leads to chronic airway disease....
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Bustamante-Marin XM, Yin WN, Sears PR, Werner ME, Brotslaw EJ, Mitchell BJ, Jania CM, Zeman KL, Rogers TD, Herring LE, Refabért L, Thomas L, Amselem S, Escudier E, Legendre M, Grubb BR, Knowles MR, Zariwala MA, Ostrowski LE. Lack of GAS2L2 Causes PCD by Impairing Cilia Orientation and Mucociliary Clearance. Am J Hum Genet. 2019 Jan 18. pii: S0002-9297(18)30460-9. doi: 10.1016/j.ajhg.2018.12.009. [Epub ahead of print].

An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy

Authors:
Liu PH, Shah RB, Li Y, Arora A, Ung PM, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V, Barbaro JM, Thompson R, White RM, Aguirre-Ghiso JA, Heymach JV, Lu KP, Silva JM, Panageas KS, Schlessinger A, Maki RG, Skinner HD, de Stanchina E, Sidi S
Citation:
Nat Cell Biol. 2019 Jan 21. doi: 10.1038/s41556-018-0260-7. [Epub ahead of print]
Abstract:
Drug-based strategies to overcome tumour resistance to radiotherapy (R-RT) remain limited by the single-agent toxicity of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu PH, Shah RB, Li Y, Arora A, Ung PM, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V, Barbaro JM, Thompson R, White RM, Aguirre-Ghiso JA, Heymach JV, Lu KP, Silva JM, Panageas KS, Schlessinger A, Maki RG, Skinner HD, de Stanchina E, Sidi S. An IRAK1-PIN1 signalling axis drives intrinsic tumour resistance to radiation therapy. Nat Cell Biol. 2019 Jan 21. doi: 10.1038/s41556-018-0260-7. [Epub ahead of print].

Blockade of a laminin-411 - Notch axis with CRISPR/Cas9 or a nanobioconjugate inhibits glioblastoma growth through tumor-microenvironment crosstalk

Authors:
Sun T, Patil R, Galstyan A, Klymyshyn D, Ding H, Chesnokova A, Cavenee WK, Furnari FB, A Ljubimov VA, Shatalova ES, Wagner S, Li D, Adam N Mamelak, Bannykh SI, Patil CG, Rudnick JD, Hu J, Grodzinski ZB, Rekechenetskiy A, Falahatian V, Chen YL, Leoh LS, Daniels-Wells TR, Penichet ML, Holler E, Ljubimov AV, Black KL, Ljubimova JY
Citation:
Cancer Res. 2019;[Epub ahead of print] doi:10.1158/0008-5472.CAN-18-2725
Abstract:
There is an unmet need for the treatment of glioblastoma multiforme (GBM). The extracellular matrix (ECM), including laminins,...
Delivery Method:
PMLA nanoparticles
Organism or Cell Type:
cell cultures: GBM cell lines LN229 & U87MG
Citation Extract:
Sun T, Patil R, Galstyan A, Klymyshyn D, Ding H, Chesnokova A, Cavenee WK, Furnari FB, A Ljubimov VA, Shatalova ES, Wagner S, Li D, Adam N Mamelak, Bannykh SI, Patil CG, Rudnick JD, Hu J, Grodzinski ZB, Rekechenetskiy A, Falahatian V, Chen YL, Leoh LS, Daniels-Wells TR, Penichet ML, Holler E, Ljubimov AV, Black KL, Ljubimova JY. Blockade of a laminin-411 - Notch axis with CRISPR/Cas9 or a nanobioconjugate inhibits glioblastoma growth through tumor-microenvironment crosstalk. Cancer Res. 2019;[Epub ahead of print] doi:10.1158/0008-5472.CAN-18-2725.

The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation

Authors:
Dorris ER, Tazzyman SJ, Moylett J, Ramamoorthi N, Hackney J, Townsend M, Muthana M, Lewis MJ, Pitzalis C, Wilson AG
Citation:
J Immunol. 2019 Jan 18. pii: ji1801155. doi: 10.4049/jimmunol.1801155. [Epub ahead of print]
Abstract:
Genetic variants in C5orf30 have been associated with development of the autoimmune conditions primary biliary cirrhosis and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dorris ER, Tazzyman SJ, Moylett J, Ramamoorthi N, Hackney J, Townsend M, Muthana M, Lewis MJ, Pitzalis C, Wilson AG. The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation. J Immunol. 2019 Jan 18. pii: ji1801155. doi: 10.4049/jimmunol.1801155. [Epub ahead of print].

N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway

Authors:
Yin Y, Xu L, Chang Y, Zeng T, Chen X, Wang A, Groth J, Foo WC, Liang C, Hu H, Huang J
Citation:
Mol Cancer. 2019 Jan 18;18(1):11. doi: 10.1186/s12943-019-0941-2
Abstract:
BACKGROUND: MYCN amplification or N-Myc overexpression is found in approximately 40% NEPC and up to 20% CRPC patients. N-Myc...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: LNCaP
Citation Extract:
Yin Y, Xu L, Chang Y, Zeng T, Chen X, Wang A, Groth J, Foo WC, Liang C, Hu H, Huang J. N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway. Mol Cancer. 2019 Jan 18;18(1):11. doi: 10.1186/s12943-019-0941-2.

Krüppel-like factor gene function in the ctenophore Mnemiopsis suggests an ancient role in promoting cell proliferation in metazoan stem cell niches

Authors:
Presnell JS, Browne WE
Citation:
bioRxiv. 2018;[Preprint] doi:10.1101/527002
Abstract:
All animals possess pluripotent stem cells that during an organism's lifespan give rise to differentiated cell types and...
Delivery Method:
microinjection
Organism or Cell Type:
Mnemiopsis leidyi (ctenophore)
Citation Extract:
Presnell JS, Browne WE. Krüppel-like factor gene function in the ctenophore Mnemiopsis suggests an ancient role in promoting cell proliferation in metazoan stem cell niches. bioRxiv. 2018;[Preprint] doi:10.1101/527002 .

Paternal genome rescues mouse preimplantation embryo development in the absence of maternally-recruited EZH2 activity

Authors:
Wang H, Paulson EE, Ma L, Ross PJ, Schultz RM
Citation:
Epigenetics. 2019 Jan 19. doi: 10.1080/15592294.2019.1570771. [Epub ahead of print]
Abstract:
Enhancer of zeste homolog 2 (EZH2), a component of the PRC2 complex, trimethylates H3K27, a transcriptionally repressive...
Organism or Cell Type:
mouse eggs & diploidized parthenotes
Citation Extract:
Wang H, Paulson EE, Ma L, Ross PJ, Schultz RM. Paternal genome rescues mouse preimplantation embryo development in the absence of maternally-recruited EZH2 activity. Epigenetics. 2019 Jan 19. doi: 10.1080/15592294.2019.1570771. [Epub ahead of print].

A dual function of FGF signaling in Xenopus left-right axis formation

Authors:
Schneider I, Kreis J, Schweickert A, Blum M, Vick P
Citation:
bioRxiv. 2018;[Preprint] doi:10.1101/469791
Abstract:
Organ left-right (LR) asymmetry is a conserved vertebrate feature, which is regulated by left-sided activation of Nodal...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Schneider I, Kreis J, Schweickert A, Blum M, Vick P. A dual function of FGF signaling in Xenopus left-right axis formation. bioRxiv. 2018;[Preprint] doi:10.1101/469791.

De Novo SOX4 Variants Cause a Neurodevelopmental Disease Associated with Mild Dysmorphism

Authors:
Zawerton A, Yao B, Yeager JP, Pippucci T, Haseeb A, Smith JD, Wischmann L, Kühl SJ, Dean JCS, Pilz DT, Holder SE, Deciphering Developmental Disorders Study, University of Washington Center for Mendelian Genomics, McNeill A, Graziano C, Lefebvre V
Citation:
Am J Hum Genet. 2019;[Epub ahead of print] doi:10.1016/j.ajhg.2018.12.014
Abstract:
SOX4, together with SOX11 and SOX12, forms group C of SRY-related (SOX) transcription factors. They play key roles, often in...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Zawerton A, Yao B, Yeager JP, Pippucci T, Haseeb A, Smith JD, Wischmann L, Kühl SJ, Dean JCS, Pilz DT, Holder SE, Deciphering Developmental Disorders Study, University of Washington Center for Mendelian Genomics, McNeill A, Graziano C, Lefebvre V. De Novo SOX4 Variants Cause a Neurodevelopmental Disease Associated with Mild Dysmorphism. Am J Hum Genet. 2019;[Epub ahead of print] doi:10.1016/j.ajhg.2018.12.014.

TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis

Authors:
Lan Y, Pan H, Li C, Banks KM, Sam J, Ding B, Elemento O, Goll MG, Evans T
Citation:
Cell Rep. 2019;26:720-32. doi:10.1016/j.celrep.2018.12.076
Abstract:
Ten-eleven translocation (Tet) enzymes (Tet1/2/3) mediate 5-methylcytosine (5mC) hydroxylation, which can facilitate DNA...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lan Y, Pan H, Li C, Banks KM, Sam J, Ding B, Elemento O, Goll MG, Evans T. TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis. Cell Rep. 2019;26:720-32. doi:10.1016/j.celrep.2018.12.076.

Pages