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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10468 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Unravelling the disease mechanism for TSPYL1 deficiency

Authors:
Buyse G, Di Michele M, Wijgaerts A, Louwette S, Wittevrongel C, Thys C, Downes K, Ceulemans B, Van Esch H, Van Geet C, Freson K
Citation:
Hum Mol Genet. 2020;[Epub aheaed of print] doi:10.1093/hmg/ddaa233
Abstract:
We describe a lethal combined nervous and reproductive systems disease in three affected siblings of a consanguineous family....
Organism or Cell Type:
zebrafish
Citation Extract:
Buyse G, Di Michele M, Wijgaerts A, Louwette S, Wittevrongel C, Thys C, Downes K, Ceulemans B, Van Esch H, Van Geet C, Freson K. Unravelling the disease mechanism for TSPYL1 deficiency. Hum Mol Genet. 2020;[Epub aheaed of print] doi:10.1093/hmg/ddaa233.

setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals

Authors:
Liu D-J, Zhang F, Chen Y, Jin Y, Zhang Y-L, Chen S-B, Xie Y-Y, Huang Q-H, Zhao W-L, Wang L, Xu P-F, Chen Z, Chen S-J, Li B, Zhang A, Sun X-J
Citation:
Cell Discov. 2020;6(1):72 doi:10.1038/s41421-020-00203-8
Abstract:
Setd2 is the only enzyme that catalyzes histone H3 lysine 36 trimethylation (H3K36me3) on virtually all actively transcribed...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu D-J, Zhang F, Chen Y, Jin Y, Zhang Y-L, Chen S-B, Xie Y-Y, Huang Q-H, Zhao W-L, Wang L, Xu P-F, Chen Z, Chen S-J, Li B, Zhang A, Sun X-J. setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals. Cell Discov. 2020;6(1):72 doi:10.1038/s41421-020-00203-8.

Hmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and Lateral Line Development

Authors:
England SJ, Cerda GA, Kowalchuk A, Sorice T, Grieb G, Lewis KE
Citation:
Genetics. 2020;[Epub ahead of print] doi:10.1534/genetics.120.303748
Abstract:
Transcription factors that contain a homeodomain DNA-binding domain have crucial functions in most aspects of cellular function...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
England SJ, Cerda GA, Kowalchuk A, Sorice T, Grieb G, Lewis KE. Hmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and Lateral Line Development. Genetics. 2020;[Epub ahead of print] doi:10.1534/genetics.120.303748.

The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG

Authors:
Landgraf K, Klöting N, Gericke M, Maixner N, Guiu-Jurado E, Scholz M, Witte AV, Beyer F, Schwartze JT, Lacher M, Villringer A, Kovacs P, Rudich A, Blüher M, Kiess W, Körner A
Citation:
Cell Rep. 2020;33(3):108295. doi:10.1016/j.celrep.2020.108295
Abstract:
TMEM18 is the strongest candidate for childhood obesity identified from GWASs, yet as for most GWAS-derived obesity-...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Landgraf K, Klöting N, Gericke M, Maixner N, Guiu-Jurado E, Scholz M, Witte AV, Beyer F, Schwartze JT, Lacher M, Villringer A, Kovacs P, Rudich A, Blüher M, Kiess W, Körner A. The Obesity-Susceptibility Gene TMEM18 Promotes Adipogenesis through Activation of PPARG. Cell Rep. 2020;33(3):108295. doi:10.1016/j.celrep.2020.108295.

AIBP-CAV1-VEGFR3 axis dictates lymphatic cell fate and controls lymphangiogenesis

Authors:
Yang X, Kim J, Gu Q, Yan Q, Astin J, Crosier P, Yu P, Rockson SG, Fang L
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.10.16.342998
Abstract:
The lymphatics are essential for the maintenance of tissue fluid homeostasis. Accordingly, lymphatic dysfunction contributes to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yang X, Kim J, Gu Q, Yan Q, Astin J, Crosier P, Yu P, Rockson SG, Fang L. AIBP-CAV1-VEGFR3 axis dictates lymphatic cell fate and controls lymphangiogenesis. bioRxiv. 2020;[preprint] doi:10.1101/2020.10.16.342998.

A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites

Authors:
Jiang N, Rasmussen JP, Clanton JA, Rosenberg MF, Luedke KP, Cronan MR, Parker ED, Kim HJ, Vaughan JC, Sagasti A, Parrish JZ
Citation:
Elife. 2019 Mar 11;8:e42455. doi:10.7554/eLife.42455
Abstract:
Interactions between epithelial cells and neurons influence a range of sensory modalities including taste, touch, and smell....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jiang N, Rasmussen JP, Clanton JA, Rosenberg MF, Luedke KP, Cronan MR, Parker ED, Kim HJ, Vaughan JC, Sagasti A, Parrish JZ. A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites. Elife. 2019 Mar 11;8:e42455. doi:10.7554/eLife.42455.

Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis

Authors:
Bhattacharya D, Rothstein M, Azambuja AP, Simoes-Costa M
Citation:
Elife. 2018 Dec 6;7:e40556. doi:10.7554/eLife.40556
Abstract:
A crucial step in cell differentiation is the silencing of developmental programs underlying multipotency. While much is known...
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Bhattacharya D, Rothstein M, Azambuja AP, Simoes-Costa M. Control of neural crest multipotency by Wnt signaling and the Lin28/let-7 axis. Elife. 2018 Dec 6;7:e40556. doi:10.7554/eLife.40556.

Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition

Authors:
Piacentino ML, Hutchins EJ, Andrews CJ, Bronner ME
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.10.18.344523
Abstract:
Epithelial-to-mesenchymal transition (EMT) is a dramatic change in cellular physiology during development and metastasis which...
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Piacentino ML, Hutchins EJ, Andrews CJ, Bronner ME. Temporal changes in plasma membrane lipid content induce endocytosis to regulate developmental epithelial-to-mesenchymal transition. bioRxiv. 2020;[preprint] doi:10.1101/2020.10.18.344523 .

Morpholino-Mediated Knockdown of Ciliary Genes in Euplotes vannus, a Novel Marine Ciliated Model Organism

Authors:
Tang D, Wang X, Dong J, Li Y, Gao F, Xie H, Zhao C
Citation:
Front Microbiol. 2020;11:254 doi:10.3389/fmicb.2020.549781
Abstract:
Cilia are highly conserved organelles present in almost all types of eukaryotic cells, and defects in cilia structure and/or...
Delivery Method:
microinjection
Organism or Cell Type:
Euplotes vannus (ciliate)
Citation Extract:
Tang D, Wang X, Dong J, Li Y, Gao F, Xie H, Zhao C. Morpholino-Mediated Knockdown of Ciliary Genes in Euplotes vannus, a Novel Marine Ciliated Model Organism. Front Microbiol. 2020;11:254 doi:10.3389/fmicb.2020.549781 .

Nonsequential Splicing Events Alter Antisense-Mediated Exon Skipping Outcome in COL7A1

Authors:
Ham KA, Aung-Htut MT, Fletcher D, Wilton SD
Citation:
Int J Molec Sci. 2020;21(20):1422-0067 doi:10.3390/ijms21207705
Abstract:
The COL7A1 gene encodes homotrimer fibrils essential for anchoring dermal and epidermal layers, and pathogenic mutations in...
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: primary human dermal fibroblasts
Citation Extract:
Ham KA, Aung-Htut MT, Fletcher D, Wilton SD. Nonsequential Splicing Events Alter Antisense-Mediated Exon Skipping Outcome in COL7A1. Int J Molec Sci. 2020;21(20):1422-0067 doi:10.3390/ijms21207705.

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