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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12062 scientific papers returned from the database with the search filters currently being used below.

Antagonistic regulation of homeologous uncx.L and uncx.S genes orchestrates myotome and sclerotome differentiation in the evolutionarily divergent vertebral column of Xenopus laevis

Authors:
Sánchez RS, Lazarte MA, Abdala VSL, Sánchez SS
Citation:
J Exp Zool B Mol Dev Evol. 2023 Dec 28. doi: 10.1002/jez.b.23235. Online ahead of print
Epub:
Yes
Abstract:
In anurans, the vertebral column diverges widely from that of other tetrapods; yet the molecular mechanisms underlying its...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Sánchez RS, Lazarte MA, Abdala VSL, Sánchez SS. Antagonistic regulation of homeologous uncx.L and uncx.S genes orchestrates myotome and sclerotome differentiation in the evolutionarily divergent vertebral column of Xenopus laevis. J Exp Zool B Mol Dev Evol. 2023 Dec 28. doi: 10.1002/jez.b.23235. Online ahead of print.

An in vivo drug screen in zebrafish reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis

Authors:
González-Llera L, Sobrido-Cameán D, Quelle-Regaldie A, Sánchez L, Barreiro-Iglesias A
Citation:
Cell Prolif. 2023 Dec 28:e13594. doi: 10.1111/cpr.13594. Online ahead of print
Epub:
Not Epub
Abstract:
The study of neurogenesis is essential to understanding fundamental developmental processes and for the development of cell...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
González-Llera L, Sobrido-Cameán D, Quelle-Regaldie A, Sánchez L, Barreiro-Iglesias A. An in vivo drug screen in zebrafish reveals that cyclooxygenase 2-derived prostaglandin D2 promotes spinal cord neurogenesis. Cell Prolif. 2023 Dec 28:e13594. doi: 10.1111/cpr.13594. Online ahead of print.

Cytoglobin regulates NO-dependent cilia motility and organ laterality during development

Authors:
Rochon ER, Xue J, Mohammed MS, Smith C, Hay-Schmidt A, DeMartino AW, Clark A, Xu Q, Lo CW, Tsang M, Tejero J, Gladwin MT, Corti P
Citation:
Nat Commun. 2023 Dec 14;14(1):8333. doi: 10.1038/s41467-023-43544-0
Epub:
Not Epub
Abstract:
Cytoglobin is a heme protein with unresolved physiological function. Genetic deletion of zebrafish cytoglobin (cygb2) causes...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rochon ER, Xue J, Mohammed MS, Smith C, Hay-Schmidt A, DeMartino AW, Clark A, Xu Q, Lo CW, Tsang M, Tejero J, Gladwin MT, Corti P. Cytoglobin regulates NO-dependent cilia motility and organ laterality during development. Nat Commun. 2023 Dec 14;14(1):8333. doi: 10.1038/s41467-023-43544-0.

A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus

Authors:
Singh AK, Allington G, Viviano S, McGee S, Kiziltug E, Ma S, Zhao S, Mekbib KY, Shohfi JP, Duy PQ, DeSpenza T Jr, Furey CG, Reeves BC, Smith H, Sousa AMM, Cherskov A, Allocco A, Nelson-Williams C, Haider S, Rizvi SRA, Alper SL, Sestan N, Shimelis H, Walsh LK, Lifton RP, Moreno-De-Luca A, Jin SC, Kruszka P, Deniz E, Kahle KT
Citation:
Brain. 2023 Dec 21:awad405. doi: 10.1093/brain/awad405. Online ahead of print
Epub:
Yes
Abstract:
Hydrocephalus, characterized by cerebral ventriculomegaly, is the most common disorder requiring brain surgery in children....
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Singh AK, Allington G, Viviano S, McGee S, Kiziltug E, Ma S, Zhao S, Mekbib KY, Shohfi JP, Duy PQ, DeSpenza T Jr, Furey CG, Reeves BC, Smith H, Sousa AMM, Cherskov A, Allocco A, Nelson-Williams C, Haider S, Rizvi SRA, Alper SL, Sestan N, Shimelis H, Walsh LK, Lifton RP, Moreno-De-Luca A, Jin SC, Kruszka P, Deniz E, Kahle KT. A novel SMARCC1 BAFopathy implicates neural progenitor epigenetic dysregulation in human hydrocephalus. Brain. 2023 Dec 21:awad405. doi: 10.1093/brain/awad405. Online ahead of print.

CRISPR/Cas9-mediated nexilin deficiency interferes with cardiac contractile function in zebrafish in vivo

Authors:
Hofeichner J, Gahr BM, Huber M, Boos A, Rottbauer W, Just S
Citation:
Sci Rep. 2023 Dec 19;13(1):22679. doi: 10.1038/s41598-023-50065-9
Epub:
Not Epub
Abstract:
Nexilin (NEXN) plays a crucial role in stabilizing the sarcomeric Z-disk of striated muscle fibers and, when mutated, leads to...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hofeichner J, Gahr BM, Huber M, Boos A, Rottbauer W, Just S. CRISPR/Cas9-mediated nexilin deficiency interferes with cardiac contractile function in zebrafish in vivo. Sci Rep. 2023 Dec 19;13(1):22679. doi: 10.1038/s41598-023-50065-9.

CLEC12A sensitizes differentially responsive breast cancer cells to the anti-cancer effects of artemisinin by repressing autophagy and inflammation

Authors:
Chatterjee R, Shukla A, Chakrabarti K, Chatterji U
Citation:
Front Oncol. 2023 Dec 8;13:1242432. doi: 10.3389/fonc.2023.1242432. eCollection 2023
Epub:
Not Epub
Abstract:
Background: Enhanced inflammatory responses promote tumor progression by activating toll-like receptors (TLRs), which in turn...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mouse 4T1 xenograft
Citation Extract:
Chatterjee R, Shukla A, Chakrabarti K, Chatterji U. CLEC12A sensitizes differentially responsive breast cancer cells to the anti-cancer effects of artemisinin by repressing autophagy and inflammation. Front Oncol. 2023 Dec 8;13:1242432. doi: 10.3389/fonc.2023.1242432. eCollection 2023.

Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1

Authors:
Feng Y, Zhang J, Li Y, Chen G, Zhang X, Ning G, Wu S
Citation:
Gene. 2023 Dec 20;898:148105. doi: 10.1016/j.gene.2023.148105. Online ahead of print. PMID: 38135256
Epub:
Not Epub
Abstract:
Phosphatidylinositol 4 kinase-β (PI4KB) plays critical roles in human genetic diseases. In zebrafish, Pi4kb is strongly...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Feng Y, Zhang J, Li Y, Chen G, Zhang X, Ning G, Wu S. Inhibition of Pi4kb activity causes malformation of vestibular apparatus in zebrafish by downregulating hey1. Gene. 2023 Dec 20;898:148105. doi: 10.1016/j.gene.2023.148105. Online ahead of print. PMID: 38135256.

Developmental adcyap1b loss leads to hemorrhage, disrupted hemostasis, and a blood coagulation cascade in zebrafish

Authors:
Ma X, Guo R, Xu H, Ma Y, Zhang R, Liu X, Zhang J, Han Y
Citation:
J Thromb Haemost. 2023 Dec 15:S1538-7836(23)00877-2. doi: 10.1016/j.jtha.2023.12.010. Online ahead of print. PMID: 38104724
Epub:
Yes
Abstract:
Background: Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) is a neuropeptide with diverse roles in biological...
Organism or Cell Type:
zebrafish
Citation Extract:
Ma X, Guo R, Xu H, Ma Y, Zhang R, Liu X, Zhang J, Han Y. Developmental adcyap1b loss leads to hemorrhage, disrupted hemostasis, and a blood coagulation cascade in zebrafish. J Thromb Haemost. 2023 Dec 15:S1538-7836(23)00877-2. doi: 10.1016/j.jtha.2023.12.010. Online ahead of print. PMID: 38104724.

The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction

Authors:
Chiang DY, Verkerk AO, Victorio R, Shneyer BI, van der Vaart B, Jouni M, Narendran N, Kc A, Sampognaro JR, Vetrano-Olsen F, Oh JS, Buys E, de Jonge B, Shah DA, Kiviniemi T, Burridge PW, Bezzina CR, Akhmanova A, MacRae CA
Citation:
Circ Res. 2023 Dec 14. doi: 10.1161/CIRCRESAHA.123.323231. Online ahead of print
Epub:
Yes
Abstract:
Background: The Brugada syndrome is associated with loss-of-function SCN5A variants, yet these account for only ≈20% of cases....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chiang DY, Verkerk AO, Victorio R, Shneyer BI, van der Vaart B, Jouni M, Narendran N, Kc A, Sampognaro JR, Vetrano-Olsen F, Oh JS, Buys E, de Jonge B, Shah DA, Kiviniemi T, Burridge PW, Bezzina CR, Akhmanova A, MacRae CA. The Role of MAPRE2 and Microtubules in Maintaining Normal Ventricular Conduction. Circ Res. 2023 Dec 14. doi: 10.1161/CIRCRESAHA.123.323231. Online ahead of print.

Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation

Authors:
Ermis E, Nargis T, Webster K, Tersey SA, Anderson RM, Mirmira RG
Citation:
J Biol Chem. 2023;[Epub ahead of print] doi:10.1016/j.jbc.2023.105561
Epub:
Yes
Abstract:
Chronic inflammation is the underlying cause of many diseases, including type 1 diabetes, obesity, and non-alcoholic fatty...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ermis E, Nargis T, Webster K, Tersey SA, Anderson RM, Mirmira RG. Leukotriene B4 receptor 2 governs macrophage migration during tissue inflammation. J Biol Chem. 2023;[Epub ahead of print] doi:10.1016/j.jbc.2023.105561.

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