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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12255 scientific papers returned from the database with the search filters currently being used below.
There are 12255 scientific papers returned from the database with the search filters currently being used below.
The effects of all-trans retinoic acid on prednisolone-induced osteoporosis in zebrafish larvae
Citation:
Bone. 2024 Dec;189:117261. doi: 10.1016/j.bone.2024.117261. Epub 2024 Sep 18. PMID: 39303930 Epub:
Not Epub Abstract:
Glucocorticoids (GCs) are extensively used as anti-inflammatory and immunosuppressive medications in the long-term treatment of... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yu T, Chen M, Wen J, Liu J, Li K, Jin L, Yue J, Yang Z, Xi J. The effects of all-trans retinoic acid on prednisolone-induced osteoporosis in zebrafish larvae. Bone. 2024 Dec;189:117261. doi: 10.1016/j.bone.2024.117261. Epub 2024 Sep 18. PMID: 39303930. |
TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival
Citation:
Cell. 2024 Sep 5:S0092-8674(24)00911-5. doi: 10.1016/j.cell.2024.08.020. Epub ahead of print. PMID: 39265577 Epub:
Not Epub Abstract:
DNA repair and autophagy are distinct biological processes vital for cell survival. Although autophagy helps maintain genome... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lascaux P, Hoslett G, Tribble S, Trugenberger C, Antičević I, Otten C, Torrecilla I, Koukouravas S, Zhao Y, Yang H, Aljarbou F, Ruggiano A, Song W, Peron C, Deangeli G, Domingo E, Bancroft J, Carrique L, Johnson E, Vendrell I, Fischer R, Ng AWT, Ngeow J, D'Angiolella V, Raimundo N, Maughan T, Popović M, Milošević I, Ramadan K. TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival. Cell. 2024 Sep 5:S0092-8674(24)00911-5. doi: 10.1016/j.cell.2024.08.020. Epub ahead of print. PMID: 39265577. |
Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease
Citation:
Nat Commun. 2024 Sep 11;15(1):7963. doi: 10.1038/s41467-024-52214-8. PMID: 39261453; PMCID: PMC11390906 Epub:
Not Epub Abstract:
Coagulation factor XII (FXII) conveys various functions as an active protease that promotes thrombosis and inflammation, and as... Delivery Method:
Vivo-Morpholino; intraperitoneal Organism or Cell Type:
C57BL/6 mice Citation Extract: Elwakiel A, Gupta D, Rana R, Manoharan J, Al-Dabet MM, Ambreen S, Fatima S, Zimmermann S, Mathew A, Li Z, Singh K, Gupta A, Pal S, Sulaj A, Kopf S, Schwab C, Baber R, Geffers R, Götze T, Alo B, Lamers C, Kluge P, Kuenze G, Kohli S, Renné T, Shahzad K, Isermann B. Factor XII signaling via uPAR-integrin β1 axis promotes tubular senescence in diabetic kidney disease. Nat Commun. 2024 Sep 11;15(1):7963. doi: 10.1038/s41467-024-52214-8. PMID: 39261453; PMCID: PMC11390906. |
TDMPP activation of estrogen receptor 2a regulates smc2 and p53 signaling to interfere with liver development in zebrafish (Danio rerio)
Citation:
J Hazard Mater. 2024 Sep 15;477:135379. doi: 10.1016/j.jhazmat.2024.135379. Epub 2024 Jul 31. PMID: 39096633 Epub:
Not Epub Abstract:
Tris (2,6-dimethylphenyl) phosphate (TDMPP), a novel organic phosphorus flame retardant (OPFR), has been found to have... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Li K, Qi Z, Xie Z, Li W, Yang X, Zhai Y, Zhou X, Xie X, Song W. TDMPP activation of estrogen receptor 2a regulates smc2 and p53 signaling to interfere with liver development in zebrafish (Danio rerio). J Hazard Mater. 2024 Sep 15;477:135379. doi: 10.1016/j.jhazmat.2024.135379. Epub 2024 Jul 31. PMID: 39096633. |
Non-coding cause of congenital heart defects: Abnormal RNA splicing with multiple isoforms as a mechanism for heterotaxy
Citation:
HGG Adv. 2024 Oct 10;5(4):100353. doi: 10.1016/j.xhgg.2024.100353. Epub 2024 Sep 12. PMID: 39275801; PMCID: PMC11470249 Epub:
Not Epub Abstract:
Heterotaxy is a disorder characterized by severe congenital heart defects (CHDs) and abnormal left-right patterning in other... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Wells JR, Padua MB, Haaning AM, Smith AM, Morris SA, Tariq M, Ware SM. Non-coding cause of congenital heart defects: Abnormal RNA splicing with multiple isoforms as a mechanism for heterotaxy. HGG Adv. 2024 Oct 10;5(4):100353. doi: 10.1016/j.xhgg.2024.100353. Epub 2024 Sep 12. PMID: 39275801; PMCID: PMC11470249. |
p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation
Citation:
Nat Commun. 2024 Sep 6;15(1):7787. doi: 10.1038/s41467-024-51922-5. PMID: 39242546; PMCID: PMC11379711 Epub:
Not Epub Abstract:
Most gene functions have been discovered through phenotypic observations under loss of function experiments that lack temporal... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Campbell CA, Calderon R, Pavani G, Cheng X, Barakat R, Snella E, Liu F, Peng X, Essner JJ, Dorman KS, McGrail M, Gadue P, French DL, Espin-Palazon R. p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation. Nat Commun. 2024 Sep 6;15(1):7787. doi: 10.1038/s41467-024-51922-5. PMID: 39242546; PMCID: PMC11379711. |
Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response
Citation:
Cell Rep. 2024 Sep 9;43(9):114719. doi: 10.1016/j.celrep.2024.114719. Epub ahead of print. PMID: 39255062 Epub:
Not Epub Abstract:
Neuroinflammation and dysregulated energy metabolism are linked to motor neuron degeneration in amyotrophic lateral sclerosis (... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Germeys C, Vandoorne T, Davie K, Poovathingal S, Heeren K, Vermeire W, Nami F, Moisse M, Quaegebeur A, Sierksma A, Rué L, Sicart A, Eykens C, De Cock L, De Strooper B, Carmeliet P, Van Damme P, De Bock K, Van Den Bosch L. Targeting EGLN2/PHD1 protects motor neurons and normalizes the astrocytic interferon response. Cell Rep. 2024 Sep 9;43(9):114719. doi: 10.1016/j.celrep.2024.114719. Epub ahead of print. PMID: 39255062. |
Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage
Citation:
Cell Death Dis. 2024 Sep 9;15(9):660. doi: 10.1038/s41419-024-07042-5. PMID: 39251572 Epub:
Not Epub Abstract:
The WD repeat-containing protein 4 (WDR4) has repeatedly been associated with primary microcephaly, a condition of impaired... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Burkhalter MD, Stiff T, Maerz LD, Casar Tena T, Wiese H, Gerhards J, Sailer SA, Vu LAT, Duong Phu M, Donow C, Alupei M, Iben S, Groth M, Wiese S, Church JA, Jeggo PA, Philipp M. Cilia defects upon loss of WDR4 are linked to proteasomal hyperactivity and ubiquitin shortage. Cell Death Dis. 2024 Sep 9;15(9):660. doi: 10.1038/s41419-024-07042-5. PMID: 39251572. |
Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution
Citation:
bioRxiv [preprint] 2024.09.05.609312; doi: https://doi.org/10.1101/2024.09.05.609312 Epub:
Not Epub Abstract:
Body axis specification is a crucial event in animal embryogenesis and was an essential evolutionary innovation for founding... Delivery Method:
microinjection Organism or Cell Type:
Clytia hemisphaerica Citation Extract: Uveira J, Donati A, Léria M, Lechable M, Lahaye F, Vesque C, Houliston E, Momose T. Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution. bioRxiv [preprint] 2024.09.05.609312; doi: https://doi.org/10.1101/2024.09.05.609312. |
Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA
Citation:
Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102331 Epub:
Not Epub Abstract:
Further development of direct-acting antiviral agents against human SARS-CoV-2 infections remains a public health priority.... Delivery Method:
peptide-linked; intranasal and intratracheal Organism or Cell Type:
cell culture: Hela-ACE2; mice: K18-hACE2 Citation Extract: Sakai A, Singh G, Khoshbakht M, Bittner S, Löhr CV, Diaz-Tapia R, Warang P, White K, Le Luo L, Tolbert B, Blanco M, Chow A, Guttman M, Li C, Bao Y, Ho J, Maurer-Stroh S, Chatterjee A, Chanda S, García-Sastre A, Schotsaert M, Teijaro JR, Moulton HM, Stein DA. Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA. Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102331. |