You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10704 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Tdrd3 regulates the progression of meiosis II through translational control of Emi2 mRNA in mouse oocytes

Authors:
Takei N, Sato K, Takada Y, Iyyappan R, Susor A, Yamamoto T, Kotani T
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.02.17.431574
Abstract:
After completion of meiosis I, the oocyte immediately enters meiosis II and forms a metaphase II (MII) spindle without an...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Takei N, Sato K, Takada Y, Iyyappan R, Susor A, Yamamoto T, Kotani T. Tdrd3 regulates the progression of meiosis II through translational control of Emi2 mRNA in mouse oocytes. bioRxiv. 2021;[preprint] doi:10.1101/2021.02.17.431574.

Mechanically Sensitive HSF1 is a Key Regulator of Left-Right Symmetry Breaking in Zebrafish Embryos

Authors:
Du J, Li SK, Guan L-Y, Guo Z, Yin J-F, Gao L, Kawanishi T, Shimada A, Zhang Q-p, Zheng L-S, Liu Y-Y, Feng X-X, Chen D-Y, Takeda H, Fan Y
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.02.25.432863
Abstract:
The left-right symmetry breaking of vertebrate embryos requires fluid flow (called nodal flow in zebrafish). However, the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Du J, Li SK, Guan L-Y, Guo Z, Yin J-F, Gao L, Kawanishi T, Shimada A, Zhang Q-p, Zheng L-S, Liu Y-Y, Feng X-X, Chen D-Y, Takeda H, Fan Y. Mechanically Sensitive HSF1 is a Key Regulator of Left-Right Symmetry Breaking in Zebrafish Embryos. bioRxiv. 2021;[preprint] doi:10.1101/2021.02.25.432863 .

Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism

Authors:
Pulgar E, Schwayer C, Guerrero N, López L, Márquez S, Härtel S, Soto R, Heisenberg CP, Concha ML
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.02.24.432660
Abstract:
The developmental strategies used by progenitor cells to endure a safe journey from their induction place towards the site of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Pulgar E, Schwayer C, Guerrero N, López L, Márquez S, Härtel S, Soto R, Heisenberg CP, Concha ML. Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism. bioRxiv. 2021;[preprint] doi:10.1101/2021.02.24.432660 .

Dlc1 controls cardio-vascular development downstream of Vegfa/Kdrl/Nrp1 signaling in the zebrafish embryo

Authors:
Linnerz T, Bertrand JY
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.02.11.430763
Abstract:
The family of deleted-in-liver-cancer (dlc) genes encodes RhoGTPases and plays pivotal roles in cardiovascular development, but...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Linnerz T, Bertrand JY. Dlc1 controls cardio-vascular development downstream of Vegfa/Kdrl/Nrp1 signaling in the zebrafish embryo. bioRxiv. 2021;[preprint] doi:10.1101/2021.02.11.430763.

Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production

Authors:
Weinreb JT, Ghazale N, Pradhan K, Gupta V, Potts KS, Tricomi B, Daniels NJ, Padgett RA, De Oliveira S, Verma A, Bowman TV
Citation:
Dev Cell. 2021;[Epub ahead of print] doi:10.1016/j.devcel.2021.02.006
Abstract:
Hematopoietic stem and progenitor cells (HSPCs) arise during embryonic development and are essential for sustaining the blood...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Weinreb JT, Ghazale N, Pradhan K, Gupta V, Potts KS, Tricomi B, Daniels NJ, Padgett RA, De Oliveira S, Verma A, Bowman TV. Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production. Dev Cell. 2021;[Epub ahead of print] doi:10.1016/j.devcel.2021.02.006.

Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns

Authors:
Olthof AM, White AK, Mieruszynski S, Doggett K, Lee MF, Chakroun A, Abdel Aleem AK, Rousseau J, Magnani C, Roifman CM, Campeau PM, Heath JK, Kanadia RN
Citation:
Nucl Acids Res. 2021;gkab118. doi:10.1093/nar/gkab118
Abstract:
Vertebrate genomes contain major (>99.5%) and minor (<0.5%) introns that are spliced by the major and minor spliceosomes...
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: HEK293T
Citation Extract:
Olthof AM, White AK, Mieruszynski S, Doggett K, Lee MF, Chakroun A, Abdel Aleem AK, Rousseau J, Magnani C, Roifman CM, Campeau PM, Heath JK, Kanadia RN. Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns. Nucl Acids Res. 2021;gkab118. doi:10.1093/nar/gkab118.

Endosomal escape cell-penetrating peptides significantly enhance pharmacological effectiveness and CNS activity of systemically administered antisense oligonucleotides

Authors:
Dastpeyman M, Sharifi R, Amin A, Karas JA, Cuic B, Pan Y, Nicolazzo JA, Turner BJ, Shabanpoor F
Citation:
Int J Pharm. 2021 Feb 25:120398. doi: 10.1016/j.ijpharm.2021.120398. Online ahead of print
Abstract:
Antisense oligonucleotides (ASOs) are an emerging class of gene-specific therapeutics for diseases associated with the central...
Delivery Method:
peptide-linked
Organism or Cell Type:
mice
Citation Extract:
Dastpeyman M, Sharifi R, Amin A, Karas JA, Cuic B, Pan Y, Nicolazzo JA, Turner BJ, Shabanpoor F. Endosomal escape cell-penetrating peptides significantly enhance pharmacological effectiveness and CNS activity of systemically administered antisense oligonucleotides. Int J Pharm. 2021 Feb 25:120398. doi: 10.1016/j.ijpharm.2021.120398. Online ahead of print.

Expression and Functional Analyses of Ectodermal Transcription Factors FoxJ-r, SoxF, and SP8/9 in Early Embryos of the Ascidian Halocynthia roretzi

Authors:
Shih Y, Wang K, Kumano G, Nishida H
Citation:
Zoolog Sci. 2021 Feb;38(1):26-35. doi: 10.2108/zs200128
Abstract:
The spatiotemporal expression of zygotic genes is regulated by transcription factors, which mediate cell fate decision and...
Delivery Method:
microinjection
Organism or Cell Type:
Halocynthia roretzi (ascidian)
Citation Extract:
Shih Y, Wang K, Kumano G, Nishida H. Expression and Functional Analyses of Ectodermal Transcription Factors FoxJ-r, SoxF, and SP8/9 in Early Embryos of the Ascidian Halocynthia roretzi. Zoolog Sci. 2021 Feb;38(1):26-35. doi: 10.2108/zs200128.

Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways

Authors:
Li GX, Zhang S, Liu R, Singh B, Singh S, Quinn DI, Crump G, Gill PS
Citation:
Biology Open. 2021;10:bio050096 doi:10.1242/bio.050096
Abstract:
The VEGF pathway is critically required for vasculogenesis, the formation of the primary vascular network. It is also required...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li GX, Zhang S, Liu R, Singh B, Singh S, Quinn DI, Crump G, Gill PS. Tetraspanin18 regulates angiogenesis through VEGFR2 and Notch pathways. Biology Open. 2021;10:bio050096 doi:10.1242/bio.050096.

ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection

Authors:
Ni S, Zhou Y, Song L, Chen Y, Wang X, Du X, Zhang S
Citation:
Commun Biol. 2021;4:251. doi:10.1038/s42003-021-01777-z
Abstract:
Previous studies have shown that ELAVL1 plays multiple roles, but its overall biological function remains ill-defined. Here we...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ni S, Zhou Y, Song L, Chen Y, Wang X, Du X, Zhang S. ELAVL1a is an immunocompetent protein that protects zebrafish embryos from bacterial infection. Commun Biol. 2021;4:251. doi:10.1038/s42003-021-01777-z.

Pages