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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9322 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors

Authors:
Maerz LD, Casar Tena T, Gerhards J, Donow C, Jeggo PA, Philipp M
Citation:
Eur J Hum Genet. 2019 Jan 29. doi: 10.1038/s41431-019-0338-0. [Epub ahead of print]
Abstract:
Meier-Gorlin syndrome (MGS) is a rare, congenital primordial microcephalic dwarfism disorder. MGS is caused by genetic variants...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Maerz LD, Casar Tena T, Gerhards J, Donow C, Jeggo PA, Philipp M. Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors. Eur J Hum Genet. 2019 Jan 29. doi: 10.1038/s41431-019-0338-0. [Epub ahead of print].

CPSF1 mutations are associated with early-onset high myopia and involved in retinal ganglion cell axon projection

Authors:
Ouyang J, Sun W, Xiao X, Li S, Jia X, Zhou L, Wang P, Zhang Q
Citation:
Hum Mol Genet. 2019 Jan 26. doi: 10.1093/hmg/ddz029. [Epub ahead of print]
Abstract:
High myopia is a severe form of nearsightedness, which can result in blindness due to its associated complications. While both...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ouyang J, Sun W, Xiao X, Li S, Jia X, Zhou L, Wang P, Zhang Q. CPSF1 mutations are associated with early-onset high myopia and involved in retinal ganglion cell axon projection. Hum Mol Genet. 2019 Jan 26. doi: 10.1093/hmg/ddz029. [Epub ahead of print].

Morpholino-Mediated Gene knockdown in Zebrafish: It's All About Dosage and Validation

Authors:
Van Gils M, Vanakker OM
Citation:
J Invest Dermatol. 2019 Jan 29. pii: S0022-202X(19)30042-9. doi: 10.1016/j.jid.2019.01.017. [Epub ahead of print]
Abstract:
No abstract available (Letter to the Editor)
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Van Gils M, Vanakker OM. Morpholino-Mediated Gene knockdown in Zebrafish: It's All About Dosage and Validation. J Invest Dermatol. 2019 Jan 29. pii: S0022-202X(19)30042-9. doi: 10.1016/j.jid.2019.01.017. [Epub ahead of print] .

Intelectin 3 is dispensable for resistance against a mycobacterial infection in zebrafish (Danio rerio)

Authors:
Ojanen MJT, Uusi-Mäkelä MIE, Harjula SE, Saralahti AK, Oksanen KE, Kähkönen N, Määttä JAE, Hytönen VP, Pesu M, Rämet M
Citation:
Sci Rep. 2019 Jan 30;9(1):995. doi: 10.1038/s41598-018-37678-1
Abstract:
Tuberculosis is a multifactorial bacterial disease, which can be modeled in the zebrafish (Danio rerio). Abdominal cavity...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ojanen MJT, Uusi-Mäkelä MIE, Harjula SE, Saralahti AK, Oksanen KE, Kähkönen N, Määttä JAE, Hytönen VP, Pesu M, Rämet M. Intelectin 3 is dispensable for resistance against a mycobacterial infection in zebrafish (Danio rerio). Sci Rep. 2019 Jan 30;9(1):995. doi: 10.1038/s41598-018-37678-1.

Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport

Authors:
Insinna C, Lu Q, Teixeira I, Harned A, Semler EM, Stauffer J, Magidson V, Tiwari A, Kenworthy AK, Narayan K, Westlake CJ
Citation:
Nat Commun. 2019 Jan 25;10(1):428. doi: 10.1038/s41467-018-08192-9
Abstract:
The intracellular ciliogenesis pathway requires membrane trafficking, fusion, and reorganization. Here, we demonstrate in human...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Insinna C, Lu Q, Teixeira I, Harned A, Semler EM, Stauffer J, Magidson V, Tiwari A, Kenworthy AK, Narayan K, Westlake CJ. Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport. Nat Commun. 2019 Jan 25;10(1):428. doi: 10.1038/s41467-018-08192-9.

Venous identity requires BMP signalling through ALK3

Authors:
Neal A, Nornes S, Payne S, Wallace MD, Fritzsche M, Louphrasitthiphol P, Wilkinson RN, Chouliaras KM, Liu K, Plant K, Sholapurkar R, Ratnayaka I, Herzog W, Bond G, Chico T, Bou-Gharios G, De Val S
Citation:
Nat Comm. 2019;10:453. doi:doi.org/10.1038/s41467-019-08315-w
Abstract:
Venous endothelial cells are molecularly and functionally distinct from their arterial counterparts. Although veins are often...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Neal A, Nornes S, Payne S, Wallace MD, Fritzsche M, Louphrasitthiphol P, Wilkinson RN, Chouliaras KM, Liu K, Plant K, Sholapurkar R, Ratnayaka I, Herzog W, Bond G, Chico T, Bou-Gharios G, De Val S. Venous identity requires BMP signalling through ALK3. Nat Comm. 2019;10:453. doi:doi.org/10.1038/s41467-019-08315-w.

Scavenger receptor class A1 mediates uptake of morpholino antisense oligonucleotide into dystrophic skeletal muscle

Authors:
Miyatake S, Mizobe Y, Tsoumpra M, Lim KRQ, Hara Y, Shabanpoor F, Yokota T, Takeda S, Aoki Y
Citation:
Mol Ther Nucl Acids. 2019 Jan 25;14:520-535. doi: 10.1016/j.omtn.2019.01.008.
Abstract:
Exon-skipping using phosphorodiamidate morpholino oligomers (PMOs) is a promising treatment strategy for Duchenne muscular...
Delivery Method:
peptide-linked, cell bathing
Organism or Cell Type:
mice mdx62, cell culture: H2K-mdx 52 myoblasts
Citation Extract:
Miyatake S, Mizobe Y, Tsoumpra M, Lim KRQ, Hara Y, Shabanpoor F, Yokota T, Takeda S, Aoki Y. Scavenger receptor class A1 mediates uptake of morpholino antisense oligonucleotide into dystrophic skeletal muscle. Mol Ther Nucl Acids. 2019 Jan 25;14:520-535. doi: 10.1016/j.omtn.2019.01.008. .

Photoreceptor cell development requires prostaglandin signaling in the zebrafish retina

Authors:
Li W, Jin D, Zhong TP
Citation:
Biochem Biophys Res Commun. 2019 Jan 24. pii: S0006-291X(19)30087-7. doi: 10.1016/j.bbrc.2019.01.073. [Epub ahead of print]
Abstract:
Photoreceptor cells are highly specialized sensory neurons capable of visual phototransduction. The connecting cilia in the...
Organism or Cell Type:
zebrafish
Citation Extract:
Li W, Jin D, Zhong TP. Photoreceptor cell development requires prostaglandin signaling in the zebrafish retina. Biochem Biophys Res Commun. 2019 Jan 24. pii: S0006-291X(19)30087-7. doi: 10.1016/j.bbrc.2019.01.073. [Epub ahead of print].

Loss of foxc1 in zebrafish reduces optic nerve size and cell number in the ganglion cell layer

Authors:
Umali J, Hawkey-Noble A, French CR
Citation:
Vision Res. 2019 Jan 23. pii: S0042-6989(19)30020-3. doi: 10.1016/j.visres.2019.01.008. [Epub ahead of print]
Abstract:
Mutation of FOXC1 causes Axenfeld-Rieger Syndrome (ARS) with early onset or congenital glaucoma. We assessed retinal ganglion...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Umali J, Hawkey-Noble A, French CR. Loss of foxc1 in zebrafish reduces optic nerve size and cell number in the ganglion cell layer. Vision Res. 2019 Jan 23. pii: S0042-6989(19)30020-3. doi: 10.1016/j.visres.2019.01.008. [Epub ahead of print].

A zebrafish model to study small-fiber neuropathy reveals a potential role for GDAP1

Authors:
Eijkenboom I, Vanoevelen JM, Hoeijmakers JGJ, Wijnen I, Gerards M, Faber CG, Smeets HJM
Citation:
Mitochondrion. 2019;[Epub ahead of print] doi:10.1016/j.mito.2019.01.002
Abstract:
Mutations in genes involved in mitochondrial dynamics (fusion and fission) have been implicated in many peripheral neuropathies...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Eijkenboom I, Vanoevelen JM, Hoeijmakers JGJ, Wijnen I, Gerards M, Faber CG, Smeets HJM. A zebrafish model to study small-fiber neuropathy reveals a potential role for GDAP1. Mitochondrion. 2019;[Epub ahead of print] doi:10.1016/j.mito.2019.01.002.

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