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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10704 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Loss of splicing factor IK impairs normal skeletal muscle development

Authors:
In Ka H, Seo H, Choi YKim J, Cho M, Choi SY, Park S, Han S, An J, Chung HS, Yang Y, Kim MJ
Citation:
BMC Biol. 2021 Apr 1;19(1):44. doi:10.1186/s12915-021-00980-y
Abstract:
Background: IK is a splicing factor that promotes spliceosome activation and contributes to pre-mRNA splicing. Although the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
In Ka H, Seo H, Choi YKim J, Cho M, Choi SY, Park S, Han S, An J, Chung HS, Yang Y, Kim MJ. Loss of splicing factor IK impairs normal skeletal muscle development. BMC Biol. 2021 Apr 1;19(1):44. doi:10.1186/s12915-021-00980-y.

A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish

Authors:
Xia J, Kang Z, Xue Y, Ding Y, Gao S, Zhang Y, Lv P, Wang X, Ma D, Wang L, Han J-DJ, Liu F
Citation:
Proc Nat Acad Sci USA. 2021;118(14):e2015748118. doi:10.1073/pnas.2015748118
Abstract:
During vertebrate embryogenesis, fetal hematopoietic stem and progenitor cells (HSPCs) exhibit expansion and differentiation...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xia J, Kang Z, Xue Y, Ding Y, Gao S, Zhang Y, Lv P, Wang X, Ma D, Wang L, Han J-DJ, Liu F. A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish. Proc Nat Acad Sci USA. 2021;118(14):e2015748118. doi:10.1073/pnas.2015748118.

Role of epigenetic m6A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR‐AKT signaling

Authors:
Parial R, Li H, Li J, Archacki S, Yang Z, Wang IZ, Chen Q, Xu C, Wang QK
Citation:
FASEB J. 2021;[Epub] doi:10.1096/fj.202000516RR
Abstract:
N6‐methyladenosine (m6A) methylation is the most prevalent RNA modification, and it emerges as an important regulatory...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Parial R, Li H, Li J, Archacki S, Yang Z, Wang IZ, Chen Q, Xu C, Wang QK. Role of epigenetic m6A RNA methylation in vascular development: mettl3 regulates vascular development through PHLPP2/mTOR‐AKT signaling. FASEB J. 2021;[Epub] doi:10.1096/fj.202000516RR.

A polo-like kinase modulates cytokinesis and flagella biogenesis in Giardia lamblia

Authors:
Park EA, Kim J, Shin MY, Park S-J
Citation:
Parasit Vectors. 2021;14:182. doi:10.1186/s13071-021-04687-5
Abstract:
Background: Polo-like kinases (PLKs) are conserved serine/threonine kinases that regulate the cell cycle. To date, the role of...
Delivery Method:
electroporation
Organism or Cell Type:
Giardia lamblia
Citation Extract:
Park EA, Kim J, Shin MY, Park S-J. A polo-like kinase modulates cytokinesis and flagella biogenesis in Giardia lamblia. Parasit Vectors. 2021;14:182. doi:10.1186/s13071-021-04687-5.

Rapid and Unamplified Identification of COVID-19 with Morpholino-Modified Graphene Field-Effect Transistor Nanosensor

Authors:
Li J, Wu D, Yu Y, Li T, Li K, Xiao M-M, Li Y, Zhang Z-Y, Zhang G-J
Citation:
Biosens Bioelectron. 2021;[Epub] doi:10.1016/j.bios.2021.113206
Abstract:
SARS-CoV-2 RNA is identified as a pivotal player to bolster energizing zones of COVID-19 detection. Herein, we develop a rapid...
Citation Extract:
Li J, Wu D, Yu Y, Li T, Li K, Xiao M-M, Li Y, Zhang Z-Y, Zhang G-J. Rapid and Unamplified Identification of COVID-19 with Morpholino-Modified Graphene Field-Effect Transistor Nanosensor. Biosens Bioelectron. 2021;[Epub] doi:10.1016/j.bios.2021.113206.

NOX5 is Expressed Aberrantly but Not a Critical Pathogenetic Gene in Hirschsprung Disease

Authors:
Wang J, Xiao J, Meng X, Chu X, Zhuansun DD, Xiong B, Feng J
Citation:
BMC Pediatr. 2021;15:123 doi:10.1186/s12887-021-02611-5
Abstract:
Background: Hirschsprung disease (HSCR) is a congenital disorder characterized by the absence of intramural ganglion cells in...
Citation Extract:
Wang J, Xiao J, Meng X, Chu X, Zhuansun DD, Xiong B, Feng J. NOX5 is Expressed Aberrantly but Not a Critical Pathogenetic Gene in Hirschsprung Disease. BMC Pediatr. 2021;15:123 doi:10.1186/s12887-021-02611-5.

Analysis of Chd-7 Defective Dauer Nematodes Implicates Collagen Misregulation in Charge Syndrome Features

Authors:
Jofré DM, Hoffman DK, Cervino AS, Grundy M, Yun S, Amrit FRG, Stolz DB, Salvatore E, Rossi FA, Ghazi A, Cirio MC, Yanowitz JL, Hochbaum D
Citation:
bioRxiv. 2021;[preprint] doi:10.1101/2021.03.26.437191
Abstract:
CHARGE syndrome is a complex developmental disorder caused by mutations in the chromodomain helicase DNA-binding protein7 (CHD7...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Jofré DM, Hoffman DK, Cervino AS, Grundy M, Yun S, Amrit FRG, Stolz DB, Salvatore E, Rossi FA, Ghazi A, Cirio MC, Yanowitz JL, Hochbaum D. Analysis of Chd-7 Defective Dauer Nematodes Implicates Collagen Misregulation in Charge Syndrome Features. bioRxiv. 2021;[preprint] doi:10.1101/2021.03.26.437191.

UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy

Authors:
Yoon MJ, Choi B, Kim EJ, Ohk J, Yang C, Choi Y-G, Lee J, Kang C, Song HK, Kim YK, Woo J-S, Cho Y, Choi E-J, Jung H, Kim C
Citation:
Nat Commun. 2021;12(1):1955. doi:10.1038/s41467-021-22252-7
Abstract:
p62/SQSTM1 is known to act as a key mediator in the selective autophagy of protein aggregates, or aggrephagy, by steering...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus tropicalis
Citation Extract:
Yoon MJ, Choi B, Kim EJ, Ohk J, Yang C, Choi Y-G, Lee J, Kang C, Song HK, Kim YK, Woo J-S, Cho Y, Choi E-J, Jung H, Kim C. UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy. Nat Commun. 2021;12(1):1955. doi:10.1038/s41467-021-22252-7.

Proof-of-Concept: Antisense Oligonucleotide Mediated Skipping of Fibrillin-1 Exon 52

Authors:
Cale JM, Greer K, Fletcher S, Wilton SD
Citation:
Int J Mol Sci. 2021;22(7):3479. doi:10.3390/ijms22073479
Abstract:
Marfan syndrome is one of the most common dominantly inherited connective tissue disorders, affecting 2–3 in 10,000 individuals...
Delivery Method:
electroporation
Organism or Cell Type:
cell culture: primary Marfan fibroblasts
Citation Extract:
Cale JM, Greer K, Fletcher S, Wilton SD. Proof-of-Concept: Antisense Oligonucleotide Mediated Skipping of Fibrillin-1 Exon 52. Int J Mol Sci. 2021;22(7):3479. doi:10.3390/ijms22073479.

RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis

Authors:
Kim H, Lee YS, Kim SM, Jang S, Choi H, Lee JW, Kim TD, Kim VN
Citation:
Dev Cell. 2021 Mar 16:S1534-5807(21)00203-3. doi: 10.1016/j.devcel.2021.03.006. Online ahead of print
Abstract:
Adenosine N6-methylation (m6A) is one of the most pervasive mRNA modifications, and yet the physiological significance of m6A...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim H, Lee YS, Kim SM, Jang S, Choi H, Lee JW, Kim TD, Kim VN. RNA demethylation by FTO stabilizes the FOXJ1 mRNA for proper motile ciliogenesis. Dev Cell. 2021 Mar 16:S1534-5807(21)00203-3. doi: 10.1016/j.devcel.2021.03.006. Online ahead of print.

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