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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 11585 scientific papers returned from the database with the search filters currently being used below.

Noncanonical protease-activated receptor 1 regulates lymphatic differentiation in zebrafish

Authors:
Lei D, Zhang X, Rouf MA, Mahendra Y, Wen L, Li Y, Zhang X, Li L, Wang L, Zhang T, Wang G, Wang Y
Citation:
iScience. 2021 Oct 30;24(11):103386. doi: 10.1016/j.isci.2021.103386. eCollection 2021 Nov 19
Epub:
Not Epub
Abstract:
The differentiation of lymphatic progenitors is a crucial step in lymphangiogenesis. However, its underlying mechanism remains...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lei D, Zhang X, Rouf MA, Mahendra Y, Wen L, Li Y, Zhang X, Li L, Wang L, Zhang T, Wang G, Wang Y. Noncanonical protease-activated receptor 1 regulates lymphatic differentiation in zebrafish. iScience. 2021 Oct 30;24(11):103386. doi: 10.1016/j.isci.2021.103386. eCollection 2021 Nov 19.

Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish

Authors:
Fasano G, Muto V, Radio FC, Venditti M, Mosaddeghzadeh N, Coppola S, Paradisi G, Zara E, Bazgir F, Ziegler A, Chillemi G, Bertuccini L, Tinari A, Vetro A, Pantaleoni F, Pizzi S, Conti LA, Petrini S, Bruselles A, Prandi IG, Mancini C, Chandramouli B, Barth M, Bris C, Milani D, Selicorni A, Macchiaiolo M, Gonfiantini MV, Bartuli A, Mariani R, Curry CJ, Guerrini R, Slavotinek A, Iascone M, Dallapiccola B, Ahmadian MR, Lauri A, Tartaglia M
Citation:
Nat Commun. 2022 Nov 11;13(1):6841. doi: 10.1038/s41467-022-34354-x
Epub:
Not Epub
Abstract:
Vesicle biogenesis, trafficking and signaling via Endoplasmic reticulum-Golgi network support essential developmental processes...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fasano G, Muto V, Radio FC, Venditti M, Mosaddeghzadeh N, Coppola S, Paradisi G, Zara E, Bazgir F, Ziegler A, Chillemi G, Bertuccini L, Tinari A, Vetro A, Pantaleoni F, Pizzi S, Conti LA, Petrini S, Bruselles A, Prandi IG, Mancini C, Chandramouli B, Barth M, Bris C, Milani D, Selicorni A, Macchiaiolo M, Gonfiantini MV, Bartuli A, Mariani R, Curry CJ, Guerrini R, Slavotinek A, Iascone M, Dallapiccola B, Ahmadian MR, Lauri A, Tartaglia M. Dominant ARF3 variants disrupt Golgi integrity and cause a neurodevelopmental disorder recapitulated in zebrafish. Nat Commun. 2022 Nov 11;13(1):6841. doi: 10.1038/s41467-022-34354-x.

The circadian rhythm regulates branched-chain amino acids metabolism in fast muscle of Chinese perch (Siniperca chuatsi) during short-term fasting by Clock-KLF15-Bcat2 pathway

Authors:
Zhu X, Liu J, Cai M, Bao L, Pan Y, Wu P, Chu W, Zhang J
Citation:
Br J Nutr. 2022 Nov 14:1-31. doi: 10.1017/S0007114522003646. Online ahead of print
Epub:
Not Epub
Abstract:
As an internal time keeping mechanism, circadian rhythm plays crucial role in maintaining homeostasis when in response to...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
Siniperca chuatsi (Chinese perch)
Citation Extract:
Zhu X, Liu J, Cai M, Bao L, Pan Y, Wu P, Chu W, Zhang J. The circadian rhythm regulates branched-chain amino acids metabolism in fast muscle of Chinese perch (Siniperca chuatsi) during short-term fasting by Clock-KLF15-Bcat2 pathway. Br J Nutr. 2022 Nov 14:1-31. doi: 10.1017/S0007114522003646. Online ahead of print.

A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience

Authors:
Wang C, Wang B, Pandey T, Long Y, Zhang J, Oh F, Sima J, Guo R, Liu Y, Zhang C, Mukherjee S, Bassik M, Lin W, Deng H, Vale G, McDonald J, Shen K, Ma DK
Citation:
Nat Comm. 2022;13:6805. doi:10.1038/s41467-022-34450-y
Epub:
Not Epub
Abstract:
Cells adapt to cold by increasing levels of unsaturated phospholipids and membrane fluidity through conserved homeostatic...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang C, Wang B, Pandey T, Long Y, Zhang J, Oh F, Sima J, Guo R, Liu Y, Zhang C, Mukherjee S, Bassik M, Lin W, Deng H, Vale G, McDonald J, Shen K, Ma DK. A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience. Nat Comm. 2022;13:6805. doi:10.1038/s41467-022-34450-y.

Planar polarized force propagation integrates cell behavior and tissue morphogenesis during convergent extension

Authors:
Weng S, Huebner R, Devitt C, Nyaoga B, Alvarado J, Wallingford J
Citation:
bioRxiv. 2022;[preprint] doi:10.1101/2022.11.08.515701
Epub:
Not Epub
Abstract:
Convergent extension (CE) is an evolutionarily conserved developmental process whereby polarized collective cell movements...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Weng S, Huebner R, Devitt C, Nyaoga B, Alvarado J, Wallingford J. Planar polarized force propagation integrates cell behavior and tissue morphogenesis during convergent extension. bioRxiv. 2022;[preprint] doi:10.1101/2022.11.08.515701 .

Syntaxin 4 is essential for hearing in human and zebrafish

Authors:
Schrauwen I, Ghaffar A, Bharadwaj T, Shah K, Rehman S, Acharya A, Liaqat K, Lin NS, Everard JL, Khan A, Ahmed ZM, Ahmad W, Riazuddin S, Leal SM
Citation:
Hum Mol Genet. 2022 Nov 10:ddac257. doi: 10.1093/hmg/ddac257. Online ahead of print
Epub:
Not Epub
Abstract:
Congenital hearing impairment is a genetically highly heterogenous disorder in which prompt recognition and intervention are...
Organism or Cell Type:
zebrafish
Citation Extract:
Schrauwen I, Ghaffar A, Bharadwaj T, Shah K, Rehman S, Acharya A, Liaqat K, Lin NS, Everard JL, Khan A, Ahmed ZM, Ahmad W, Riazuddin S, Leal SM. Syntaxin 4 is essential for hearing in human and zebrafish. Hum Mol Genet. 2022 Nov 10:ddac257. doi: 10.1093/hmg/ddac257. Online ahead of print.

The apical ciliary adhesion complex is established at the basal foot of motile cilia and depends on the microtubule network

Authors:
Chatzifrangkeskou M, Skourides PA
Citation:
Sci Rep. 2022 Nov 8;12(1):19028. doi: 10.1038/s41598-022-22871-0
Epub:
Not Epub
Abstract:
The Ciliary Adhesion (CA) complex forms in close association with the basal bodies of cilia during the early stages of...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Chatzifrangkeskou M, Skourides PA. The apical ciliary adhesion complex is established at the basal foot of motile cilia and depends on the microtubule network. Sci Rep. 2022 Nov 8;12(1):19028. doi: 10.1038/s41598-022-22871-0.

Acupuncture Needle-Based Transistor Neuroprobe for In Vivo Monitoring of Neurotransmitter

Authors:
Zhou Y, Liu B, Lei Y, Tang L, Li T, Yu S, Zhang GJ, Li YT
Citation:
Small. 2022 Nov 7:e2204142. doi: 10.1002/smll.202204142. Online ahead of print
Epub:
Not Epub
Abstract:
Nevertheless, in vivo real-time monitoring of neurotransmitters released in the brain, especially the electrochemically...
Organism or Cell Type:
rat
Citation Extract:
Zhou Y, Liu B, Lei Y, Tang L, Li T, Yu S, Zhang GJ, Li YT. Acupuncture Needle-Based Transistor Neuroprobe for In Vivo Monitoring of Neurotransmitter. Small. 2022 Nov 7:e2204142. doi: 10.1002/smll.202204142. Online ahead of print.

osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2

Authors:
Drummond BE, Chambers BE, Wesselman HM, Gibson S, Arceri L, Ulrich MN, Gerlach GF, Kroeger PT, Leshchiner I, Goessling W, Wingert RA
Citation:
Biomedicines. 2022;10(11):2868. doi:10.3390/biomedicines10112868
Epub:
Not Epub
Abstract:
Knowledge about the genetic pathways that control nephron development is essential for better understanding the basis of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Drummond BE, Chambers BE, Wesselman HM, Gibson S, Arceri L, Ulrich MN, Gerlach GF, Kroeger PT, Leshchiner I, Goessling W, Wingert RA. osr1 Maintains Renal Progenitors and Regulates Podocyte Development by Promoting wnt2ba via the Antagonism of hand2. Biomedicines. 2022;10(11):2868. doi:10.3390/biomedicines10112868.

Antibody-oligonucleotide conjugate achieves central nervous system delivery in animal models for spinal muscular atrophy

Authors:
Hammond SM, Abendroth F, Goli L, Stoodley J, Burrell M, Thom G, Gurrell I, Ahlskog N, Gait MJ, Wood MJ, Webster CI
Citation:
JCI Insight. 2022 Nov 8:e154142. doi: 10.1172/jci.insight.154142. Online ahead of print
Epub:
Yes
Abstract:
Antisense oligonucleotides (ASOs) have emerged as one of the most innovative new genetic drug modalities. However, their high...
Delivery Method:
antibody-linked
Organism or Cell Type:
mice
Citation Extract:
Hammond SM, Abendroth F, Goli L, Stoodley J, Burrell M, Thom G, Gurrell I, Ahlskog N, Gait MJ, Wood MJ, Webster CI. Antibody-oligonucleotide conjugate achieves central nervous system delivery in animal models for spinal muscular atrophy. JCI Insight. 2022 Nov 8:e154142. doi: 10.1172/jci.insight.154142. Online ahead of print.

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