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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12067 scientific papers returned from the database with the search filters currently being used below.

An alternative strategy to increasing influenza virus replication for vaccine production in chicken embryo fibroblast (DF-1) cells by inhibiting interferon alpha and beta using peptide-conjugated phosphorodiamidate morpholino oligomers

Authors:
Prescott MA, Moulton H, Pastey MK
Citation:
J Med Microbiol. 2024 Feb;73(2). doi: 10.1099/jmm.0.001807
Epub:
Not Epub
Abstract:
Introduction. Influenza is a global health issue causing substantial health and economic burdens on affected populations....
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: DF-1 chick embryo fibroblasts
Citation Extract:
Prescott MA, Moulton H, Pastey MK. An alternative strategy to increasing influenza virus replication for vaccine production in chicken embryo fibroblast (DF-1) cells by inhibiting interferon alpha and beta using peptide-conjugated phosphorodiamidate morpholino oligomers. J Med Microbiol. 2024 Feb;73(2). doi: 10.1099/jmm.0.001807.

Comprehensive analysis of diel rhythmic expression of the medaka toll-like receptor gene family

Authors:
Hata T, Shimawaki H, Setoguchi S, Morimoto N, Hikima J-i, Sakai M, Kono T
Citation:
Dev Comp Immunol. 2024;[Epub] doi:10.1016/j.dci.2024.105143
Epub:
Not Epub
Abstract:
Several immune-related genes, including Toll-like receptors (TLR), are associated with circadian rhythms in mammals. However,...
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Hata T, Shimawaki H, Setoguchi S, Morimoto N, Hikima J-i, Sakai M, Kono T. Comprehensive analysis of diel rhythmic expression of the medaka toll-like receptor gene family. Dev Comp Immunol. 2024;[Epub] doi:10.1016/j.dci.2024.105143.

Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance

Authors:
Pucci G, Minafra L, Bravatà V, Calvaruso M, Turturici G, Cammarata FP, Savoca G, Abbate B, Russo G, Cavalieri V, Forte GI
Citation:
Int J Mol Sci. 2024;25(4):2079; doi:10.3390/ijms25042079
Epub:
Not Epub
Abstract:
The hypoxic pattern of glioblastoma (GBM) is known to be a primary cause of radioresistance. Our study explored the possibility...
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: U87 human glioblastoma
Citation Extract:
Pucci G, Minafra L, Bravatà V, Calvaruso M, Turturici G, Cammarata FP, Savoca G, Abbate B, Russo G, Cavalieri V, Forte GI. Glut-3 Gene Knockdown as a Potential Strategy to Overcome Glioblastoma Radioresistance. Int J Mol Sci. 2024;25(4):2079; doi:10.3390/ijms25042079.

Znf687 recruits Brd4-Smrt complex to regulate gfi1aa during neutrophil development

Authors:
Yan L, Tan S, Wang H, Yuan H, Liu X, Chen Y, de Thé H, Zhu J, Zhou J
Citation:
Leukemia. 2024;[Epub] doi:10.1038/s41375-024-02165-2
Epub:
Not Epub
Abstract:
Neutrophils are key component of the innate immune system in vertebrates. Diverse transcription factors and cofactors act in a...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Yan L, Tan S, Wang H, Yuan H, Liu X, Chen Y, de Thé H, Zhu J, Zhou J. Znf687 recruits Brd4-Smrt complex to regulate gfi1aa during neutrophil development. Leukemia. 2024;[Epub] doi:10.1038/s41375-024-02165-2.

Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator

Authors:
Knabl P, Schauer A, Pomreinke AP, Zimmermann B, Rogers KW, Čapek D, Müller P, Genikhovich G
Citation:
Elife. 2024 Feb 7;13:e80803. doi: 10.7554/eLife.80803
Epub:
Not Epub
Abstract:
BMP signaling has a conserved function in patterning the dorsal-ventral body axis in Bilateria and the directive axis in...
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Knabl P, Schauer A, Pomreinke AP, Zimmermann B, Rogers KW, Čapek D, Müller P, Genikhovich G. Analysis of SMAD1/5 target genes in a sea anemone reveals ZSWIM4-6 as a novel BMP signaling modulator. Elife. 2024 Feb 7;13:e80803. doi: 10.7554/eLife.80803.

Synthesis of Self Permeable Antisense PMO Using C5-Guanidino-Functionalized Pyrimidines at the 5'-End Enables Sox2 Downregulation in Triple Negative Breast Cancer Cells

Authors:
Das A, Gupta S, Shaw P, Sinha S
Citation:
Mol Pharm. 2024 Feb 7. doi: 10.1021/acs.molpharmaceut.3c00924. Online ahead of print
Epub:
Not Epub
Abstract:
Delivery of macromolecular drugs inside cells has been a huge challenge in the field of oligonucleotide therapeutics for the...
Delivery Method:
base-linked guanidinium
Organism or Cell Type:
cell culture: triple-negative breast cancer cell line MDA-MB 231
Citation Extract:
Das A, Gupta S, Shaw P, Sinha S. Synthesis of Self Permeable Antisense PMO Using C5-Guanidino-Functionalized Pyrimidines at the 5'-End Enables Sox2 Downregulation in Triple Negative Breast Cancer Cells. Mol Pharm. 2024 Feb 7. doi: 10.1021/acs.molpharmaceut.3c00924. Online ahead of print.

Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes

Authors:
Sun J, Li M, Sun H, Lin Z, Shi B, Jia Z
Citation:
J Hum Genet. 2024. doi:10.1038/s10038-024-01222-z
Epub:
Not Epub
Abstract:
Background: Non-syndromic orofacial cleft (NSOC) is one of the most common craniofacial malformations with complex etiology....
Organism or Cell Type:
zebrafish
Citation Extract:
Sun J, Li M, Sun H, Lin Z, Shi B, Jia Z. Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes. J Hum Genet. 2024. doi:10.1038/s10038-024-01222-z.

Knockdown of best1 Gene in Zebrafish Caused Abnormal Neuronal and Skeletal Development -A Subtype of Craniovertebral Junction Malformation

Authors:
Liu Z, Li K, Wang K, Zhang L, Jia S, Wang H, Jian F, Wu H
Citation:
Neurospine. 2024 Feb 1. doi: 10.14245/ns.2347238.619. Online ahead of print
Epub:
Not Epub
Abstract:
Objective: To investigate the developmental defects caused by knockdown of best1 gene in zebrafish as a model for a subtype of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu Z, Li K, Wang K, Zhang L, Jia S, Wang H, Jian F, Wu H. Knockdown of best1 Gene in Zebrafish Caused Abnormal Neuronal and Skeletal Development -A Subtype of Craniovertebral Junction Malformation. Neurospine. 2024 Feb 1. doi: 10.14245/ns.2347238.619. Online ahead of print.

TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning

Authors:
de Calbiac H, Montealegre S, Straube M, Renault S, Debruge H, Chentout L, Ciura S, Imbard A, Le Guillou E, Marian A, Goudin N, Caccavelli L, Fabrega S, Hubas A, van Endert P, Dupont N, Diana J, Kabashi E, de Lonlay P
Citation:
Autophagy rep. 2024;3(1):[Epub] doi:10.1080/27694127.2024.2306766
Epub:
Not Epub
Abstract:
Patients with pathogenic variants in the TANGO2 gene suffer from severe and recurrent rhabdomyolysis episodes precipitated by...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
de Calbiac H, Montealegre S, Straube M, Renault S, Debruge H, Chentout L, Ciura S, Imbard A, Le Guillou E, Marian A, Goudin N, Caccavelli L, Fabrega S, Hubas A, van Endert P, Dupont N, Diana J, Kabashi E, de Lonlay P. TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning. Autophagy rep. 2024;3(1):[Epub] doi:10.1080/27694127.2024.2306766.

Endocardium gives rise to blood cells in zebrafish embryos

Authors:
Gurung S, Restrepo NK, Sumanas S
Citation:
Cell Rep. 2024 Feb 1;43(2):113736. doi: 10.1016/j.celrep.2024.113736. Online ahead of print
Epub:
Not Epub
Abstract:
Previous studies have suggested that the endocardium contributes to hematopoiesis in murine embryos, although definitive...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gurung S, Restrepo NK, Sumanas S. Endocardium gives rise to blood cells in zebrafish embryos. Cell Rep. 2024 Feb 1;43(2):113736. doi: 10.1016/j.celrep.2024.113736. Online ahead of print.

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