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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 10101 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain

Authors:
Liu D, Yang F, Liu Z, Wang J, Huang W, Meng W, Billadeau DD, Sun Q, Mo X, Jia D
Citation:
PLoS Biol. 2020;18(5):e3000746. doi:10.1371/journal.pbio.3000746
Abstract:
Members of the Tre2-Bub2-Cdc16 (TBC) family often function to regulate membrane trafficking and to control signaling...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu D, Yang F, Liu Z, Wang J, Huang W, Meng W, Billadeau DD, Sun Q, Mo X, Jia D. Structure of TBC1D23 N-terminus reveals a novel role for rhodanese domain. PLoS Biol. 2020;18(5):e3000746. doi:10.1371/journal.pbio.3000746.

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development

Authors:
Wolf EJ, Miles A, Lee ES, Nabeel-Shah S, Greenblatt JF, Palazzo AF, Tropepe V, Emili A
Citation:
Cell Rep. 2020;31(8):107693. doi:10.1016/j.celrep.2020.107693
Abstract:
The mammalian mRNA nuclear export process is thought to terminate at the cytoplasmic face of the nuclear pore complex through...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wolf EJ, Miles A, Lee ES, Nabeel-Shah S, Greenblatt JF, Palazzo AF, Tropepe V, Emili A. MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development. Cell Rep. 2020;31(8):107693. doi:10.1016/j.celrep.2020.107693.

Safety, Tolerability, and Efficacy of Viltolarsen in Boys With Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping

Authors:
Clemens PR, Rao VK, Connolly AM, Harper AD, Mah JK, Smith EC, McDonald CM, Zaidman CM, Morgenroth LP, Osaki H, Satou Y, Yamashita T, Hoffman EP, for the CINRG DNHS Investigators
Citation:
JAMA Neurology. 2020;[Epub] doi:10.1001/jamaneurol.2020.1264
Abstract:
Importance: An unmet need remains for safe and efficacious treatments for Duchenne muscular dystrophy (DMD). To date, there...
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Clemens PR, Rao VK, Connolly AM, Harper AD, Mah JK, Smith EC, McDonald CM, Zaidman CM, Morgenroth LP, Osaki H, Satou Y, Yamashita T, Hoffman EP, for the CINRG DNHS Investigators. Safety, Tolerability, and Efficacy of Viltolarsen in Boys With Duchenne Muscular Dystrophy Amenable to Exon 53 Skipping. JAMA Neurology. 2020;[Epub] doi:10.1001/jamaneurol.2020.1264.

Aryl hydrocarbon receptor-mediated down-regulation of sox9b causes jaw malformation in zebrafish embryos

Authors:
Xiong KM, Peterson RE, Heideman W
Citation:
Mol Pharmacol. 2008 Dec;74(6):1544-53. doi:10.1124/mol.108.050435
Abstract:
Exposure to environmental contaminants can disrupt normal development of the early vertebrate skeleton. 2,3,7,8-...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xiong KM, Peterson RE, Heideman W. Aryl hydrocarbon receptor-mediated down-regulation of sox9b causes jaw malformation in zebrafish embryos. Mol Pharmacol. 2008 Dec;74(6):1544-53. doi:10.1124/mol.108.050435.

Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks

Authors:
Zhou Q, Perovic T, Fechner I, Edgar LT, Hoskins PR, Gerhardt H, Krüger T, Bernabeu MO
Citation:
bioRxiv. 2020;[preprint] doi:10.1101/2020.05.21.106914
Abstract:
Sprouting angiogenesis is an essential vascularisation mechanism and consists of two phases: sprouting and remodelling. The...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhou Q, Perovic T, Fechner I, Edgar LT, Hoskins PR, Gerhardt H, Krüger T, Bernabeu MO. Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks. bioRxiv. 2020;[preprint] doi:10.1101/2020.05.21.106914 .

Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function

Authors:
Stanicek L, Lozano-Vidal N, Bink DI, Hooglugt A, Yao W, Wittig I, van Rijssel J, van Buul JD, van Bergen A, Klems A, Ramms AS, Le Noble F, Hofmann P, Szulcek R, Wang S, Offermanns S, Ercanoglu MS, Kwon H-B, Stainier D, Huveneers S, Kurian L, Dimmeler S, Boon RA
Citation:
Commun Biol. 3030;3:265 doi:10.1038/s42003-020-0987-0
Abstract:
Blood vessels are constantly exposed to shear stress, a biomechanical force generated by blood flow. Normal shear stress...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Stanicek L, Lozano-Vidal N, Bink DI, Hooglugt A, Yao W, Wittig I, van Rijssel J, van Buul JD, van Bergen A, Klems A, Ramms AS, Le Noble F, Hofmann P, Szulcek R, Wang S, Offermanns S, Ercanoglu MS, Kwon H-B, Stainier D, Huveneers S, Kurian L, Dimmeler S, Boon RA. Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function. Commun Biol. 3030;3:265 doi:10.1038/s42003-020-0987-0.

FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection

Authors:
Langevin C, Aleksejeva E, Houel A, Briolat V, Torhy C, Lunazzi A, Levraud J-P, Boudinot P
Citation:
Front Immunol. 2017;8:617. doi: 10.3389/fimmu.2017.00617
Abstract:
Tripartite motif (TRIM) proteins are involved in various cellular functions and constitute key factors of the antiviral innate...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Langevin C, Aleksejeva E, Houel A, Briolat V, Torhy C, Lunazzi A, Levraud J-P, Boudinot P. FTR83, a Member of the Large Fish-Specific finTRIM Family, Triggers IFN Pathway and Counters Viral Infection. Front Immunol. 2017;8:617. doi: 10.3389/fimmu.2017.00617.

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Authors:
de Calbiac H, Dabacan A, Muresan R, Kabashi E, Ciura S
Citation:
J Vis Exp. 2020:e58837. doi:10.3791/58837
Abstract:
Epilepsy represents one of the most common neurological disorders, affecting an estimated 50 million people worldwide. Recent...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
de Calbiac H, Dabacan A, Muresan R, Kabashi E, Ciura S. Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy. J Vis Exp. 2020:e58837. doi:10.3791/58837.

Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation

Authors:
Guerra J, Valadao A-L, D. Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, B. Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N
Citation:
Sci Adv. 2020;6(1):eaax3333 doi:10.1126/sciadv.aax3333
Abstract:
Inflammation is an essential part of immunity against pathogens and tumors but can promote disease if not tightly regulated....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Guerra J, Valadao A-L, D. Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, B. Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N. Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation. Sci Adv. 2020;6(1):eaax3333 doi:10.1126/sciadv.aax3333.

Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation

Authors:
Gambini A, Stein A, Savy V, Grow EJ, Papas BN, Zhang Y, Kenan AC, Padilla-Banks E, Cairns BR, Williams CJ
Citation:
Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.04.018
Abstract:
Embryonic genome activation (EGA) is orchestrated by an intrinsic developmental program initiated during oocyte maturation with...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Gambini A, Stein A, Savy V, Grow EJ, Papas BN, Zhang Y, Kenan AC, Padilla-Banks E, Cairns BR, Williams CJ. Developmentally Programmed Tankyrase Activity Upregulates β-Catenin and Licenses Progression of Embryonic Genome Activation. Dev Cell. 2020;[Epub ahead of print] doi:10.1016/j.devcel.2020.04.018.

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