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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12138 scientific papers returned from the database with the search filters currently being used below.

An RNA interference approach for functional studies in the sea urchin and its use in analysis of Nodal signaling gradients

Authors:
Wilson K, Manner C, Miranda E, Berrio A, Wray G, McClay DR
Citation:
bioRxiv [Preprint]. 2024.06.20.599930; doi: https://doi.org/10.1101/2024.06.20.599930
Epub:
Not Epub
Abstract:
We report the first RNAi-based gene knockdowns in a sea urchin. Dicer-Substrate interfering RNAs (DsiRNAs) successfully...
Link:
https://www.biorxiv.org/content/10.1101/2024.06.20.599930v1.full
Delivery Method:
microinjection
Organism or Cell Type:
Lytechinus variagatus (sea urchin)
Citation Extract:
Wilson K, Manner C, Miranda E, Berrio A, Wray G, McClay DR. An RNA interference approach for functional studies in the sea urchin and its use in analysis of Nodal signaling gradients. bioRxiv [Preprint]. 2024.06.20.599930; doi: https://doi.org/10.1101/2024.06.20.599930.

U4 snRNP inhibits premature cleavage and polyadenylation of pre-mRNAs

Authors:
Feng Q, Zhao D, Lin Z, Li M, Xiang AP, Ye C, Yao C
Citation:
Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2406710121. doi: 10.1073/pnas.2406710121. Epub 2024 Jun 25. PMID: 38917004
Epub:
Not Epub
Abstract:
The essential role of U4 snRNP in pre-messenger RNA (mRNA) splicing has been well established. In this study, we utilized an...
Link:
https://www.pnas.org/doi/10.1073/pnas.2406710121
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Feng Q, Zhao D, Lin Z, Li M, Xiang AP, Ye C, Yao C. U4 snRNP inhibits premature cleavage and polyadenylation of pre-mRNAs. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2406710121. doi: 10.1073/pnas.2406710121. Epub 2024 Jun 25. PMID: 38917004.

Survival among patients receiving eteplirsen for up to 8 years for the treatment of Duchenne muscular dystrophy and contextualization with natural history controls

Authors:
Iff J, Done N, Tuttle E, Zhong Y, Wei F, Darras BT, McDonald CM, Mercuri E, Muntoni F
Citation:
Muscle Nerve. 2024 Jul;70(1):60-70. doi: 10.1002/mus.28075. Epub 2024 Mar 14. PMID: 38482981
Epub:
Not Epub
Abstract:
Eteplirsen, approved in the US for patients with Duchenne muscular dystrophy (DMD) with exon 51 skip-amenable variants, is...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/mus.28075
Delivery Method:
i.v. infusion
Organism or Cell Type:
human
Citation Extract:
Iff J, Done N, Tuttle E, Zhong Y, Wei F, Darras BT, McDonald CM, Mercuri E, Muntoni F. Survival among patients receiving eteplirsen for up to 8 years for the treatment of Duchenne muscular dystrophy and contextualization with natural history controls. Muscle Nerve. 2024 Jul;70(1):60-70. doi: 10.1002/mus.28075. Epub 2024 Mar 14. PMID: 38482981.

Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells

Authors:
Flentke GR, Wilkie TE, Baulch J, Huang Y, Smith SM
Citation:
PLoS One. 2024 Jun 28;19(6):e0304557. doi: 10.1371/journal.pone.0304557. eCollection 2024. PMID: 38941348
Epub:
Not Epub
Abstract:
Prenatal alcohol exposure (PAE) causes cognitive impairment and a distinctive craniofacial dysmorphology, due in part to...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0304557
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Flentke GR, Wilkie TE, Baulch J, Huang Y, Smith SM. Alcohol exposure suppresses ribosome biogenesis and causes nucleolar stress in cranial neural crest cells. PLoS One. 2024 Jun 28;19(6):e0304557. doi: 10.1371/journal.pone.0304557. eCollection 2024. PMID: 38941348.

Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation

Authors:
Lusk S, LaPotin S, Presnell JS, Kwan KM
Citation:
bioRxiv [Preprint]. 2024 Jun 22:2024.06.18.599642. doi: 10.1101/2024.06.18.599642. PMID: 38948711
Epub:
Not Epub
Abstract:
Uveal coloboma, a developmental eye defect, is caused by failed development of the optic fissure, a ventral structure in the...
Link:
https://www.biorxiv.org/content/10.1101/2024.06.18.599642v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lusk S, LaPotin S, Presnell JS, Kwan KM. Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation. bioRxiv [Preprint]. 2024 Jun 22:2024.06.18.599642. doi: 10.1101/2024.06.18.599642. PMID: 38948711.

3-Hydroxykynurenine targets kainate receptors to promote defense against infection

Authors:
Parada-Kusz M, Clatworthy AE, Goering ER, Blackwood SM, Shigeta JY, Mashin E, Salm EJ, Choi C, Combs S, Lee JSW, Rodriguez-Osorio C, Clish C, Tomita S, Hung DT
Citation:
Nat Chem Biol. 2024 Jun 19. doi: 10.1038/s41589-024-01635-z. Epub ahead of print. PMID: 38898166
Epub:
Not Epub
Abstract:
Bacterial infection involves a complex interaction between the pathogen and host where the outcome of infection is not solely...
Link:
https://www.nature.com/articles/s41589-024-01635-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Parada-Kusz M, Clatworthy AE, Goering ER, Blackwood SM, Shigeta JY, Mashin E, Salm EJ, Choi C, Combs S, Lee JSW, Rodriguez-Osorio C, Clish C, Tomita S, Hung DT. 3-Hydroxykynurenine targets kainate receptors to promote defense against infection. Nat Chem Biol. 2024 Jun 19. doi: 10.1038/s41589-024-01635-z. Epub ahead of print. PMID: 38898166.

CCSer2 gates dynein activity at the cell periphery

Authors:
Zang JL, Gibson D, Zheng AM, Shi W, Gillies JP, Stein C, Drerup CM, DeSantis ME
Citation:
bioRxiv [preprint] 2024.06.13.598865; doi: https://doi.org/10.1101/2024.06.13.598865
Epub:
Not Epub
Abstract:
Cytoplasmic dynein-1 (dynein) is a microtubule-associated, minus end-directed motor that traffics hundreds of different cargos...
Link:
https://www.biorxiv.org/content/10.1101/2024.06.13.598865v2.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zang JL, Gibson D, Zheng AM, Shi W, Gillies JP, Stein C, Drerup CM, DeSantis ME. CCSer2 gates dynein activity at the cell periphery. bioRxiv [preprint] 2024.06.13.598865; doi: https://doi.org/10.1101/2024.06.13.598865.

Cytokines IL-1β and IL-10 are required for Müller glia proliferation following light damage in the adult zebrafish retina

Authors:
Lu C & Hyde DR
Citation:
Front. Cell Dev. Biol., 13 June 2024. Sec. Molecular and Cellular Pathology. Volume 12 - 2024
Epub:
Not Epub
Abstract:
Zebrafish possess the ability to regenerate dying neurons in response to retinal injury, with both Müller glia and microglia...
Link:
https://www.frontiersin.org/articles/10.3389/fcell.2024.1406330
Delivery Method:
intravitreal injection and electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Lu C & Hyde DR. Cytokines IL-1β and IL-10 are required for Müller glia proliferation following light damage in the adult zebrafish retina. Front. Cell Dev. Biol., 13 June 2024. Sec. Molecular and Cellular Pathology. Volume 12 - 2024.

Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions

Authors:
Tanaka K, Chen M, Prendergast A, Zhuang Z, Nasiri A, Joshi D, Hintzen J, Chung M, Kumar A, Mani A, Koleske A, Crawford J, Nicoli S, Schwartz MA
Citation:
EMBO J. 2024 Jun 17. doi: 10.1038/s44318-024-00142-0. Epub ahead of print. PMID: 38886581
Epub:
Not Epub
Abstract:
Endothelial cell responses to fluid shear stress from blood flow are crucial for vascular development, function, and disease. A...
Link:
https://www.embopress.org/doi/full/10.1038/s44318-024-00142-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tanaka K, Chen M, Prendergast A, Zhuang Z, Nasiri A, Joshi D, Hintzen J, Chung M, Kumar A, Mani A, Koleske A, Crawford J, Nicoli S, Schwartz MA. Latrophilin-2 mediates fluid shear stress mechanotransduction at endothelial junctions. EMBO J. 2024 Jun 17. doi: 10.1038/s44318-024-00142-0. Epub ahead of print. PMID: 38886581.

A β-catenin chromobody-based probe highlights endothelial maturation during vascular morphogenesis in vivo

Authors:
Gauvrit S, Zhao S, Rothbauer U, Stainier DYR
Citation:
Development. 2024 Jun 1;151(11):dev202122. doi: 10.1242/dev.202122. Epub 2024 Jun 7. PMID: 38847494.
Epub:
Not Epub
Abstract:
Visualization of protein dynamics is a crucial step in understanding cellular processes. Chromobodies, fluorescently labelled...
Link:
https://doi.org/10.1242/dev.202122
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gauvrit S, Zhao S, Rothbauer U, Stainier DYR. A β-catenin chromobody-based probe highlights endothelial maturation during vascular morphogenesis in vivo. Development. 2024 Jun 1;151(11):dev202122. doi: 10.1242/dev.202122. Epub 2024 Jun 7. PMID: 38847494..

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