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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 9382 scientific papers returned from the database with the search filters currently being used below.

If you know of a publication that is not in this database and you feel it should be, please submit a new publication to the database and we'll get it in there.

Genetic mosaics and time-lapse imaging identify functions of histone H3.3 residues in mouse oocytes and embryos

Authors:
Zhou L, Baibakov B, Canagarajah B, Xiong B, Dean J
Citation:
Development. 2017 Feb 1;144(3):519-528. doi: 10.1242/dev.141390. Epub 2016 Dec 19
Abstract:
During development from oocyte to embryo, genetic programs in mouse germ cells are reshaped by chromatin remodeling to...
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocyte
Citation Extract:
Zhou L, Baibakov B, Canagarajah B, Xiong B, Dean J. Genetic mosaics and time-lapse imaging identify functions of histone H3.3 residues in mouse oocytes and embryos. Development. 2017 Feb 1;144(3):519-528. doi: 10.1242/dev.141390. Epub 2016 Dec 19.

Loss of function of Kmt2d, a gene mutated in Kabuki syndrome, affects heart development in Xenopus laevis

Authors:
Schwenty-Lara J, Nürnberger A, Borchers A
Citation:
Dev Dyn. 2019 Apr 13. doi: 10.1002/dvdy.39. [Epub ahead of print]
Abstract:
BACKGROUND: Kabuki syndrome is a haploinsufficient congenital multi-organ malformation syndrome, which frequently includes...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Schwenty-Lara J, Nürnberger A, Borchers A. Loss of function of Kmt2d, a gene mutated in Kabuki syndrome, affects heart development in Xenopus laevis. Dev Dyn. 2019 Apr 13. doi: 10.1002/dvdy.39. [Epub ahead of print].

The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network

Authors:
Grocott T, Lozano-Velasco E, Mok GF, Münsterberg AE
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/583807
Abstract:
Understanding how complex organ systems are assembled from simple embryonic tissues is a major challenge. Across the animal...
Delivery Method:
Endo-Porter PEG
Organism or Cell Type:
cell culture: Gallus gallus (chick) somite tissue
Citation Extract:
Grocott T, Lozano-Velasco E, Mok GF, Münsterberg AE. The Pax6 master control gene initiates spontaneous retinal development via a self-organising Turing network. bioRxiv. 2019;[preprint] doi:10.1101/583807.

Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

Authors:
Wei L, Blader P, Roussigné M
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/570820
Abstract:
Coordinated migration of cell collectives is important during embryonic development and relies on cells integrating multiple...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wei L, Blader P, Roussigné M. Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration. bioRxiv. 2019;[preprint] doi:10.1101/570820.

Developmentally regulated tcf7l2 splice variants mediate transcriptional repressor functions during eye formation

Authors:
Young RM, Ewan KB, Ferrer VP, Allende ML, Dale TC, Wilson SW
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/607713
Abstract:
Tcf7l2 mediates Wnt/β-Catenin signalling during development and is implicated in cancer and type-2 diabetes. The mechanisms by...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Young RM, Ewan KB, Ferrer VP, Allende ML, Dale TC, Wilson SW. Developmentally regulated tcf7l2 splice variants mediate transcriptional repressor functions during eye formation. bioRxiv. 2019;[preprint] doi:10.1101/607713 .

miR‐181a/b downregulation exerts a protective action on mitochondrial disease models

Authors:
Indrieri A, Carrella S, Romano A, Spaziano A, Marrocco E, Fernandez‐Vizarra E, Barbato S, Pizzo M, Ezhova Y, Golia FM, Ciampi L, Tammaro R, Henao‐Mejia J, Williams A, Flavell RA, De Leonibus E, Zeviani M, Surace EM, Banfi S, Franco B
Citation:
EMBO Molec Med. 2019;e8734 [Epub ahead of print] doi:10.15252/emmm.201708734
Abstract:
Mitochondrial diseases (MDs) are a heterogeneous group of devastating and often fatal disorders due to defective oxidative...
Delivery Method:
microinjection
Organism or Cell Type:
Oryzias latipes (medaka)
Citation Extract:
Indrieri A, Carrella S, Romano A, Spaziano A, Marrocco E, Fernandez‐Vizarra E, Barbato S, Pizzo M, Ezhova Y, Golia FM, Ciampi L, Tammaro R, Henao‐Mejia J, Williams A, Flavell RA, De Leonibus E, Zeviani M, Surace EM, Banfi S, Franco B. miR‐181a/b downregulation exerts a protective action on mitochondrial disease models. EMBO Molec Med. 2019;e8734 [Epub ahead of print] doi:10.15252/emmm.201708734.

In Ovo Electroporation of Plasmid DNA and Morpholinos into Specific Tissues During Early Embryogenesis

Authors:
McLennan R, Kulesa PM
Citation:
Neural Crest Cells. 2019. Methods in Molecular Biology (1976):71-82 Springer New York, New York, NY. doi:10.1007/978-1-4939-9412-0_6
Abstract:
In ovo electroporation enables transfection of non-viral plasmid DNA and/or morpholinos to fluorescently label and/or perturb...
Delivery Method:
electroporation
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
McLennan R, Kulesa PM. In Ovo Electroporation of Plasmid DNA and Morpholinos into Specific Tissues During Early Embryogenesis. Neural Crest Cells. 2019. Methods in Molecular Biology (1976):71-82 Springer New York, New York, NY. doi:10.1007/978-1-4939-9412-0_6.

Neutrophils use selective autophagy receptor p62 to target Staphylococcus aureus for degradation in the zebrafish model

Authors:
Gibson JF, Prajsnar TK, Serba JJ, Tonge RD, Grierson AJ, Ingham PW, Renshaw SA, Johnston SA
Citation:
bioRxiv. 2019;[preprint] doi:10.1101/604884
Abstract:
Autophagy leads to degradation of cellular components, and has an important role in destroying intracellular pathogens....
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gibson JF, Prajsnar TK, Serba JJ, Tonge RD, Grierson AJ, Ingham PW, Renshaw SA, Johnston SA . Neutrophils use selective autophagy receptor p62 to target Staphylococcus aureus for degradation in the zebrafish model. bioRxiv. 2019;[preprint] doi:10.1101/604884 .

Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation

Authors:
Ando H, Sato T, Ito T, Yamamoto J, Sakamoto S, Nitta N, Asatsuma-Okumura T, Shimizu N, Mizushima R, Aoki I, Imai T, Yamaguchi Y, Berk AJ, Handa H
Citation:
iScience. 2019;[Epub ahead of print] doi:10.1016/j.isci.2019.04.007
Abstract:
Thalidomide is a teratogen that causes multiple malformations in the developing baby through its interaction with Cereblon (...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ando H, Sato T, Ito T, Yamamoto J, Sakamoto S, Nitta N, Asatsuma-Okumura T, Shimizu N, Mizushima R, Aoki I, Imai T, Yamaguchi Y, Berk AJ, Handa H . Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation. iScience. 2019;[Epub ahead of print] doi:10.1016/j.isci.2019.04.007.

A High-Throughput Assay for Congenital and Age-Related Eye Diseases in Zebrafish

Authors:
Brastrom LK, Scott CA, Dawson DV, Slusarski DC
Citation:
Biomedicines. 2019;7(2):28 doi:10.3390/biomedicines7020028
Abstract:
Debilitating visual impairment caused by cataracts or microphthalmia is estimated to affect roughly 20 million people in the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Brastrom LK, Scott CA, Dawson DV, Slusarski DC. A High-Throughput Assay for Congenital and Age-Related Eye Diseases in Zebrafish. Biomedicines. 2019;7(2):28 doi:10.3390/biomedicines7020028.

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