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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12402 scientific papers returned from the database with the search filters currently being used below.

Conception and Synthesis of Sequence-Coded Morpholinos

Authors:
Pousse B, Al Ouahabi A, Baxter PNW, Charles L, Lutz JF
Citation:
Chemistry. 2025 May 22;31(29):e202501161. doi: 10.1002/chem.202501161. Epub 2025 Apr 29. PMID: 40227092; PMCID: PMC12099184
Epub:
Not Epub
Abstract:
Solid-phase morpholino chemistry was explored as a new route to synthesize abiological sequence-defined oligomers. Two...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12099184/
Delivery Method:
none
Organism or Cell Type:
none
Citation Extract:
Pousse B, Al Ouahabi A, Baxter PNW, Charles L, Lutz JF. Conception and Synthesis of Sequence-Coded Morpholinos. Chemistry. 2025 May 22;31(29):e202501161. doi: 10.1002/chem.202501161. Epub 2025 Apr 29. PMID: 40227092; PMCID: PMC12099184.

Silencing mitochondrial gene expression in living cells

Authors:
Cruz-Zaragoza LD, Dahal D, Koschel M, Boshnakovska A, Zheenbekova A, Yilmaz M, Morgenstern M, Dohrke JN, Bender J, Valpadashi A, Henningfeld KA, Oeljeklaus S, Kremer LS, Breuer M, Urbach O, Dennerlein S, Lidschreiber M, Jakobs S, Warscheid B, Rehling P
Citation:
Science. 2025 May 22:eadr3498. doi: 10.1126/science.adr3498. Epub ahead of print. PMID: 40403134
Epub:
Not Epub
Abstract:
Mitochondria fulfill central functions in metabolism and energy supply. They express their own genome, which encodes key...
Link:
https://www.science.org/doi/10.1126/science.adr3498
Delivery Method:
peptide-linked (pCox41-25)
Organism or Cell Type:
HEK293T cells & isolated mitochondria
Citation Extract:
Cruz-Zaragoza LD, Dahal D, Koschel M, Boshnakovska A, Zheenbekova A, Yilmaz M, Morgenstern M, Dohrke JN, Bender J, Valpadashi A, Henningfeld KA, Oeljeklaus S, Kremer LS, Breuer M, Urbach O, Dennerlein S, Lidschreiber M, Jakobs S, Warscheid B, Rehling P. Silencing mitochondrial gene expression in living cells. Science. 2025 May 22:eadr3498. doi: 10.1126/science.adr3498. Epub ahead of print. PMID: 40403134.

Redox Homeostasis within the Drug-Resistant Malarial Parasite Digestive Vacuole

Authors:
Willems A, Oertel T, Roepe PD
Citation:
Biochemistry. 2025 May 20;64(10):2247-2261. doi: 10.1021/acs.biochem.4c00750. Epub 2025 May 1. PMID: 40311147; PMCID: PMC12096432
Epub:
Not Epub
Abstract:
We have developed a cost-effective strategy for the complete synthesis of azetidinyl coumarin fluorophore derivatives that...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12096432/
Delivery Method:
none
Organism or Cell Type:
intraerythrocytic Plasmodium falciparum
Citation Extract:
Willems A, Oertel T, Roepe PD. Redox Homeostasis within the Drug-Resistant Malarial Parasite Digestive Vacuole. Biochemistry. 2025 May 20;64(10):2247-2261. doi: 10.1021/acs.biochem.4c00750. Epub 2025 May 1. PMID: 40311147; PMCID: PMC12096432.

Bi-allelic variants in POPDC2 cause an autosomal recessive syndrome presenting with cardiac conduction defects and hypertrophic cardiomyopathy

Authors:
Nicastro M, Vermeer AMC, Postema PG, Tadros R, Bowling FZ, Aegisdottir HM, Tragante V, Mach L, Postma AV, Lodder EM, van Duijvenboden K, Zwart R, Beekman L, Wu L, Jurgens SJ, van der Zwaag PA, Alders M, Allouba M, Aguib Y, Santome JL, de Una D, Monserrat L, Miranda AMA, Kanemaru K, Cranley J, van Zeggeren IE, Aronica EMA, Ripolone M, Zanotti S, Sveinbjornsson G, Ivarsdottir EV, Hólm H, Guðbjartsson DF, Skúladóttir ÁT, Stefánsson K, Nadauld L, Knowlton KU, Ostrowski SR, Sørensen E, Vesterager Pedersen OB, Ghouse J, Rand SA, Bundgaard H, Ullum H, Erikstrup C, Aagaard B et al.
Citation:
Am J Hum Genet. 2025 May 20:S0002-9297(25)00179-X. doi: 10.1016/j.ajhg.2025.04.016. Epub ahead of print. PMID: 40409267
Epub:
Not Epub
Abstract:
POPDC2 encodes the Popeye domain-containing protein 2, which has an important role in cardiac pacemaking and conduction, due in...
Link:
https://www.cell.com/ajhg/fulltext/S0002-9297(25)00179-X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nicastro M, Vermeer AMC, Postema PG, Tadros R, Bowling FZ, Aegisdottir HM, Tragante V, Mach L, Postma AV, Lodder EM, van Duijvenboden K, Zwart R, Beekman L, Wu L, Jurgens SJ, van der Zwaag PA, Alders M, Allouba M, Aguib Y, Santome JL, de Una D, Monserrat L, Miranda AMA, Kanemaru K, Cranley J, van Zeggeren IE, Aronica EMA, Ripolone M, Zanotti S, Sveinbjornsson G, Ivarsdottir EV, Hólm H, Guðbjartsson DF, Skúladóttir ÁT, Stefánsson K, Nadauld L, Knowlton KU, Ostrowski SR, Sørensen E, Vesterager Pedersen OB, Ghouse J, Rand SA, Bundgaard H, Ullum H, Erikstrup C, Aagaard B et al.. Bi-allelic variants in POPDC2 cause an autosomal recessive syndrome presenting with cardiac conduction defects and hypertrophic cardiomyopathy. Am J Hum Genet. 2025 May 20:S0002-9297(25)00179-X. doi: 10.1016/j.ajhg.2025.04.016. Epub ahead of print. PMID: 40409267.

Novel centriolar defects underlie a primary ciliary dyskinesia phenotype in an adenylate kinase 7 deficient ciliated epithelium

Authors:
Sheridan J, Grata A, Dorr J, Suva EE, Bresteau E, Mitchell LR, Hassan O, Mitchell B
Citation:
Dev Biol. 2025 May 15:S0012-1606(25)00134-4. doi: 10.1016/j.ydbio.2025.05.011. Epub ahead of print. PMID: 40381709
Epub:
Not Epub
Abstract:
The skin of Xenopus embryos contains numerous multiciliated cells (MCCs), which collectively generate a directed fluid flow...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0012160625001344
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Sheridan J, Grata A, Dorr J, Suva EE, Bresteau E, Mitchell LR, Hassan O, Mitchell B. Novel centriolar defects underlie a primary ciliary dyskinesia phenotype in an adenylate kinase 7 deficient ciliated epithelium. Dev Biol. 2025 May 15:S0012-1606(25)00134-4. doi: 10.1016/j.ydbio.2025.05.011. Epub ahead of print. PMID: 40381709.

KDM6A Deficiency Induces Myeloid Bias and Promotes CMML-Like Disease Through JAK/STAT3 Activation by Repressing SOCS3

Authors:
Chen H, Wang S, Dong R, Yu P, Li T, Hu L, Wang M, Qian Z, Zhou H, Yue X, Wang L, Xiao H
Citation:
Adv Sci (Weinh). 2025 May 14:e2413091. doi: 10.1002/advs.202413091. Epub ahead of print. PMID: 40365824
Epub:
Not Epub
Abstract:
Chronic myelomonocytic leukemia (CMML) is a hematologic malignancy with a poor prognosis and limited targeted therapies. Lysine...
Link:
https://advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202413091
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen H, Wang S, Dong R, Yu P, Li T, Hu L, Wang M, Qian Z, Zhou H, Yue X, Wang L, Xiao H. KDM6A Deficiency Induces Myeloid Bias and Promotes CMML-Like Disease Through JAK/STAT3 Activation by Repressing SOCS3. Adv Sci (Weinh). 2025 May 14:e2413091. doi: 10.1002/advs.202413091. Epub ahead of print. PMID: 40365824.

Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation

Authors:
Chen S, Liang J, Yin J, Zhang W, Jiang P, Wang W, Chen X, Zhou Y, Xia P, Yang F, Gu Y, Zhang R, Han P
Citation:
bioRxiv [preprint] 2024.05.09.593293; doi: https://doi.org/10.1101/2024.05.09.593293
Epub:
Not Epub
Abstract:
Biomechanical cues play an essential role in sculpting organ formation. Comprehending how cardiac cells perceive and respond to...
Link:
https://www.biorxiv.org/content/10.1101/2024.05.09.593293v3.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen S, Liang J, Yin J, Zhang W, Jiang P, Wang W, Chen X, Zhou Y, Xia P, Yang F, Gu Y, Zhang R, Han P. Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation. bioRxiv [preprint] 2024.05.09.593293; doi: https://doi.org/10.1101/2024.05.09.593293.

Establishing dorsal-ventral patterning in human neural tube organoids with synthetic organizers

Authors:
Luo T, Liu C, Cheng T, Zhao GQ, Huang Y, Luan JY, Guo J, Liu X, Wang YF, Dong Y, Xiao Y, He E, Sun RZ, Chen X, Chen J, Ma J, Megason S, Ji J, Xu PF
Citation:
Cell Stem Cell. 2025 May 7:S1934-5909(25)00178-X. doi: 10.1016/j.stem.2025.04.011. Epub ahead of print. PMID: 40373768
Epub:
Not Epub
Abstract:
Precise dorsal-ventral (D-V) patterning of the neural tube (NT) is essential for the development and function of the central...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S193459092500178X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Luo T, Liu C, Cheng T, Zhao GQ, Huang Y, Luan JY, Guo J, Liu X, Wang YF, Dong Y, Xiao Y, He E, Sun RZ, Chen X, Chen J, Ma J, Megason S, Ji J, Xu PF. Establishing dorsal-ventral patterning in human neural tube organoids with synthetic organizers. Cell Stem Cell. 2025 May 7:S1934-5909(25)00178-X. doi: 10.1016/j.stem.2025.04.011. Epub ahead of print. PMID: 40373768.

Phosphorylation by Aurora kinase A facilitates cortical-cytoplasmic dynamics of Par-3 in asymmetric division of radial glia progenitors

Authors:
Garcia JQ, Mouilleau V, Ng H, Zhao X, Morgan DO, Guo S
Citation:
Sci Adv. 2025 May 16;11(20):eadq3858. doi: 10.1126/sciadv.adq3858. Epub 2025 May 14. PMID: 40367180; PMCID: PMC12077515
Epub:
Not Epub
Abstract:
During asymmetric cell division (ACD) of radial glia progenitors (RGPs), the cortical polarity regulator Par-3 is detected in...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12077515/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Garcia JQ, Mouilleau V, Ng H, Zhao X, Morgan DO, Guo S. Phosphorylation by Aurora kinase A facilitates cortical-cytoplasmic dynamics of Par-3 in asymmetric division of radial glia progenitors. Sci Adv. 2025 May 16;11(20):eadq3858. doi: 10.1126/sciadv.adq3858. Epub 2025 May 14. PMID: 40367180; PMCID: PMC12077515.

A new severe congenital neutropenia syndrome associated with autosomal recessive COPZ1 mutations

Authors:
Borbaran Bravo N, Deordieva E, Doll L, ElGamacy M, Dannenmann B, Azevedo J, Iannuzzo A, Delafontaine S, Lehners M, Kolodziej M, Hernandez Alvarez B, Hellmuth AS, Ritter M, Findik B, Zakharova V, Bräuning S, Kandabarau S, Lengerke C, Feil R, Meyts I, Delon J, Templin M, Sturm M, Rieß O, Zeidler C, Welte K, Shcherbina A, Klimiankou M, Skokowa J
Citation:
Blood. 2025 May 15;145(20):2317-2335. doi: 10.1182/blood.2023022576. PMID: 39642330
Epub:
Not Epub
Abstract:
We have identified a new inherited bone marrow failure syndrome with severe congenital neutropenia (CN) caused by autosomal...
Link:
https://ashpublications.org/blood/article/145/20/2317/526299/A-new-severe-congenital-neutropenia-syndrome
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Borbaran Bravo N, Deordieva E, Doll L, ElGamacy M, Dannenmann B, Azevedo J, Iannuzzo A, Delafontaine S, Lehners M, Kolodziej M, Hernandez Alvarez B, Hellmuth AS, Ritter M, Findik B, Zakharova V, Bräuning S, Kandabarau S, Lengerke C, Feil R, Meyts I, Delon J, Templin M, Sturm M, Rieß O, Zeidler C, Welte K, Shcherbina A, Klimiankou M, Skokowa J. A new severe congenital neutropenia syndrome associated with autosomal recessive COPZ1 mutations. Blood. 2025 May 15;145(20):2317-2335. doi: 10.1182/blood.2023022576. PMID: 39642330.

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