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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12062 scientific papers returned from the database with the search filters currently being used below.

Synthesis of Self Permeable Antisense PMO Using C5-Guanidino-Functionalized Pyrimidines at the 5'-End Enables Sox2 Downregulation in Triple Negative Breast Cancer Cells

Authors:
Das A, Gupta S, Shaw P, Sinha S
Citation:
Mol Pharm. 2024 Feb 7. doi: 10.1021/acs.molpharmaceut.3c00924. Online ahead of print
Epub:
Not Epub
Abstract:
Delivery of macromolecular drugs inside cells has been a huge challenge in the field of oligonucleotide therapeutics for the...
Delivery Method:
base-linked guanidinium
Organism or Cell Type:
cell culture: triple-negative breast cancer cell line MDA-MB 231
Citation Extract:
Das A, Gupta S, Shaw P, Sinha S. Synthesis of Self Permeable Antisense PMO Using C5-Guanidino-Functionalized Pyrimidines at the 5'-End Enables Sox2 Downregulation in Triple Negative Breast Cancer Cells. Mol Pharm. 2024 Feb 7. doi: 10.1021/acs.molpharmaceut.3c00924. Online ahead of print.

Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes

Authors:
Sun J, Li M, Sun H, Lin Z, Shi B, Jia Z
Citation:
J Hum Genet. 2024. doi:10.1038/s10038-024-01222-z
Epub:
Not Epub
Abstract:
Background: Non-syndromic orofacial cleft (NSOC) is one of the most common craniofacial malformations with complex etiology....
Organism or Cell Type:
zebrafish
Citation Extract:
Sun J, Li M, Sun H, Lin Z, Shi B, Jia Z. Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes. J Hum Genet. 2024. doi:10.1038/s10038-024-01222-z.

Knockdown of best1 Gene in Zebrafish Caused Abnormal Neuronal and Skeletal Development -A Subtype of Craniovertebral Junction Malformation

Authors:
Liu Z, Li K, Wang K, Zhang L, Jia S, Wang H, Jian F, Wu H
Citation:
Neurospine. 2024 Feb 1. doi: 10.14245/ns.2347238.619. Online ahead of print
Epub:
Not Epub
Abstract:
Objective: To investigate the developmental defects caused by knockdown of best1 gene in zebrafish as a model for a subtype of...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu Z, Li K, Wang K, Zhang L, Jia S, Wang H, Jian F, Wu H. Knockdown of best1 Gene in Zebrafish Caused Abnormal Neuronal and Skeletal Development -A Subtype of Craniovertebral Junction Malformation. Neurospine. 2024 Feb 1. doi: 10.14245/ns.2347238.619. Online ahead of print.

TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning

Authors:
de Calbiac H, Montealegre S, Straube M, Renault S, Debruge H, Chentout L, Ciura S, Imbard A, Le Guillou E, Marian A, Goudin N, Caccavelli L, Fabrega S, Hubas A, van Endert P, Dupont N, Diana J, Kabashi E, de Lonlay P
Citation:
Autophagy rep. 2024;3(1):[Epub] doi:10.1080/27694127.2024.2306766
Epub:
Not Epub
Abstract:
Patients with pathogenic variants in the TANGO2 gene suffer from severe and recurrent rhabdomyolysis episodes precipitated by...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
de Calbiac H, Montealegre S, Straube M, Renault S, Debruge H, Chentout L, Ciura S, Imbard A, Le Guillou E, Marian A, Goudin N, Caccavelli L, Fabrega S, Hubas A, van Endert P, Dupont N, Diana J, Kabashi E, de Lonlay P. TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning. Autophagy rep. 2024;3(1):[Epub] doi:10.1080/27694127.2024.2306766.

Endocardium gives rise to blood cells in zebrafish embryos

Authors:
Gurung S, Restrepo NK, Sumanas S
Citation:
Cell Rep. 2024 Feb 1;43(2):113736. doi: 10.1016/j.celrep.2024.113736. Online ahead of print
Epub:
Not Epub
Abstract:
Previous studies have suggested that the endocardium contributes to hematopoiesis in murine embryos, although definitive...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gurung S, Restrepo NK, Sumanas S. Endocardium gives rise to blood cells in zebrafish embryos. Cell Rep. 2024 Feb 1;43(2):113736. doi: 10.1016/j.celrep.2024.113736. Online ahead of print.

R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient

Authors:
Lee H, Camuto CM, Niehrs C
Citation:
Nat Commun. 2024 Feb 2;15(1):1003. doi: 10.1038/s41467-024-44951-7
Epub:
Not Epub
Abstract:
Establishment of the left-right (LR, sinistral, dextral) body axis in many vertebrate embryos relies on cilia-driven leftward...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Lee H, Camuto CM, Niehrs C. R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient. Nat Commun. 2024 Feb 2;15(1):1003. doi: 10.1038/s41467-024-44951-7.

Prdm15 acts upstream of Wnt4 signaling in anterior neural development of Xenopus laevis

Authors:
Saumweber E, Mzoughi S, Khadra A, Werberger A, Schumann S, Guccione E, Schmeisser MJ, Kühl1 SJ
Citation:
Front Cell Dev Biol. 2024;12:[Epub ahead of full .pdf] doi:10.3389/fcell.2024.1316048
Epub:
Not Epub
Abstract:
Mutations in PRDM15 lead to a syndromic form of holoprosencephaly (HPE) known as Galloway-Mowat syndrome (GAMOS). While a...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Saumweber E, Mzoughi S, Khadra A, Werberger A, Schumann S, Guccione E, Schmeisser MJ, Kühl1 SJ. Prdm15 acts upstream of Wnt4 signaling in anterior neural development of Xenopus laevis. Front Cell Dev Biol. 2024;12:[Epub ahead of full .pdf] doi:10.3389/fcell.2024.1316048.

Generation of glial cell-derived neurotrophic factor (gdnf) morphants in zebrafish larvae by cerebroventricular microinjection of vivo morpholino

Authors:
Noor SM, Wong CED, Wong PF, Norazit A
Citation:
Methods Cell Biol. 2024;181:17-32. doi: 10.1016/bs.mcb.2022.09.004. Epub 2022 Oct 31
Epub:
Not Epub
Abstract:
Dopaminergic neurons in the brain are an important source of dopamine, which is a crucial neurotransmitter for wellbeing,...
Delivery Method:
intracerebroventricular (i.c.v.) injection of Vivo-Morpholino
Organism or Cell Type:
zebrafish
Citation Extract:
Noor SM, Wong CED, Wong PF, Norazit A. Generation of glial cell-derived neurotrophic factor (gdnf) morphants in zebrafish larvae by cerebroventricular microinjection of vivo morpholino. Methods Cell Biol. 2024;181:17-32. doi: 10.1016/bs.mcb.2022.09.004. Epub 2022 Oct 31.

Awakening adult neural stem cells: NOX signalling as a positive regulator of the quiescence-to-proliferation transition in the Xenopus retina

Authors:
Donval A, Puente CVH, Lainé A, Roman D, Vessely R, Leclercq J, Perron M, Locker M
Citation:
Development. 2024;151(2):dev201463. doi: 10.1242/dev.201463
Epub:
Not Epub
Abstract:
A growing wealth of data suggest that reactive oxygen species (ROS) signalling might be crucial in conferring embryonic or...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis, Xenopus tropicalis
Citation Extract:
Donval A, Puente CVH, Lainé A, Roman D, Vessely R, Leclercq J, Perron M, Locker M. Awakening adult neural stem cells: NOX signalling as a positive regulator of the quiescence-to-proliferation transition in the Xenopus retina. Development. 2024;151(2):dev201463. doi: 10.1242/dev.201463.

GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment

Authors:
Williams CH, Neitzel LR, Cornell J, Rea S, Mills I, Silver MS, Ahmad JD, Birukov KG, Birukova A, Brem H, Tyler B, Bar EE, Hong CC
Citation:
Exp Hematol Oncol. 2024 Jan 31;13(1):13. doi: 10.1186/s40164-023-00468-1
Epub:
Not Epub
Abstract:
Background: Glioblastoma multiforme (GBM) stands as a formidable challenge in oncology because of its aggressive nature and...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Williams CH, Neitzel LR, Cornell J, Rea S, Mills I, Silver MS, Ahmad JD, Birukov KG, Birukova A, Brem H, Tyler B, Bar EE, Hong CC. GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment. Exp Hematol Oncol. 2024 Jan 31;13(1):13. doi: 10.1186/s40164-023-00468-1.

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