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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12179 scientific papers returned from the database with the search filters currently being used below.

Dysregulated Protease Homeostasis Defines Primary FSGS

Authors:
Schmidt J, Sopel N, Rist C, Ohs A, Dawid L, Simm S, Catanese L, Rupprecht H, Jobst-Schwan T, Lehmann J, Daniel C, Kalkhof S, Schiffer M, Müller-Deile J
Citation:
Kidney360. 2026 Mar 1;7(3):487-500. doi: 10.34067/KID.0000001021. Epub 2025 Nov 10. PMID: 41910486
Epub:
Not Epub
Abstract:
Serum proteomics reveals reduced serpin family A member 1 (SERPINA1) in primary FSGS, distinguishing it from other proteinuric...
Link:
https://journals.lww.com/kidney360/fulltext/2026/03000/dysregulated_protease_homeostasis_defines_primary.8.aspx
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Schmidt J, Sopel N, Rist C, Ohs A, Dawid L, Simm S, Catanese L, Rupprecht H, Jobst-Schwan T, Lehmann J, Daniel C, Kalkhof S, Schiffer M, Müller-Deile J. Dysregulated Protease Homeostasis Defines Primary FSGS. Kidney360. 2026 Mar 1;7(3):487-500. doi: 10.34067/KID.0000001021. Epub 2025 Nov 10. PMID: 41910486.

The nBAF complex subunit CREST/SS18L1 regulates hippocampal memory processes via tyrosine 397 and histone acetyltransferase CBP

Authors:
Garcia FG, Farias de Albuquerque M, Johnson V, Kramár E, Changizi K, Abdelkarim S, Augustynski AS, Matheos DP, Picone J, Fetterly TL, Rodriguez A, Childs J, Gomez-Arboledas A, Winter J, Heller E, Baldi P, Wood MA
Citation:
Cell Rep. 2026 Mar 25;45(4):117158. doi: 10.1016/j.celrep.2026.117158. Epub ahead of print. PMID: 41886450
Epub:
Not Epub
Abstract:
Chromatin-modifying and -remodeling machineries are important for learning-induced transcriptional activity, yet it remains...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00236-6
Delivery Method:
Vivo-Morpholino; bilateral infusion into the dorsal hippocampus
Organism or Cell Type:
C57BL/6J & CBP conditional knockout mice
Citation Extract:
Garcia FG, Farias de Albuquerque M, Johnson V, Kramár E, Changizi K, Abdelkarim S, Augustynski AS, Matheos DP, Picone J, Fetterly TL, Rodriguez A, Childs J, Gomez-Arboledas A, Winter J, Heller E, Baldi P, Wood MA. The nBAF complex subunit CREST/SS18L1 regulates hippocampal memory processes via tyrosine 397 and histone acetyltransferase CBP. Cell Rep. 2026 Mar 25;45(4):117158. doi: 10.1016/j.celrep.2026.117158. Epub ahead of print. PMID: 41886450.

Blood vessel-resident macrophages safeguard blood and vessel integrity in zebrafish

Authors:
Weijts B, Demmers JAA & Robin C
Citation:
Nat Immunol (2026). https://doi.org/10.1038/s41590-026-02481-y
Epub:
Not Epub
Abstract:
Tissue-resident macrophages populate nearly all organs, where they adopt tissue-specific roles essential for immune defense,...
Link:
https://www.nature.com/articles/s41590-026-02481-y
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Weijts B, Demmers JAA & Robin C. Blood vessel-resident macrophages safeguard blood and vessel integrity in zebrafish. Nat Immunol (2026). https://doi.org/10.1038/s41590-026-02481-y.

Role of Glutamate Receptor-Related Genes in Myopia Occurrence and Visual Development

Authors:
Wang R, Tao D, Lu J, Li J, Liu X, Chen C
Citation:
Curr Eye Res. 2026 Mar 10:1-11. doi: 10.1080/02713683.2026.2637650. Epub ahead of print. PMID: 41804850
Epub:
Not Epub
Abstract:
Purpose: Abnormal expression of glutamate receptors is believed to be associated with myopia. However, it is currently unclear...
Link:
https://www.tandfonline.com/doi/full/10.1080/02713683.2026.2637650
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang R, Tao D, Lu J, Li J, Liu X, Chen C. Role of Glutamate Receptor-Related Genes in Myopia Occurrence and Visual Development. Curr Eye Res. 2026 Mar 10:1-11. doi: 10.1080/02713683.2026.2637650. Epub ahead of print. PMID: 41804850.

TRIM7-mediated autophagy-lysosomal signaling is essential for preimplantation development in mice

Authors:
Khan S, Yan F, Li W, Guo J, Gu X, Tang Z, Bibi U, Dong X, Chen L, Yao Y, Xu J
Citation:
J Transl Med. 2026 Mar 17. doi: 10.1186/s12967-026-07963-z. Epub ahead of print. PMID: 41845426
Epub:
Not Epub
Abstract:
Background: Pre-implantation development in mammals requires precise coordination of zygote genome activation (ZGA), cleavage...
Link:
https://link.springer.com/article/10.1186/s12967-026-07963-z
Delivery Method:
Vivo-Morpholino culture
Organism or Cell Type:
mouse zygote
Citation Extract:
Khan S, Yan F, Li W, Guo J, Gu X, Tang Z, Bibi U, Dong X, Chen L, Yao Y, Xu J. TRIM7-mediated autophagy-lysosomal signaling is essential for preimplantation development in mice. J Transl Med. 2026 Mar 17. doi: 10.1186/s12967-026-07963-z. Epub ahead of print. PMID: 41845426.

PPMO-based exon skipping therapy improves respiratory function in the mdx mouse model of Duchenne muscular dystrophy

Authors:
Biswas DD, Rodriguez MYH, El Haddad L, Hoffmann G, Copson E, Mayman S, Jose J, Lang S, Chen O, Dela Pena A, Levin E, Abdelbarr M, Slyne A, ElMallah MK
Citation:
Mol Ther Nucleic Acids. 2025 Dec 26;37(1):102810. doi: 10.1016/j.omtn.2025.102810. PMID: 41552386; PMCID: PMC12809079
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a severe X-linked recessive disorder caused by a deficiency of dystrophin, leading to...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(25)00364-6
Delivery Method:
peptide-linked, intravenous (i.v.) injection
Organism or Cell Type:
mdx mice
Citation Extract:
Biswas DD, Rodriguez MYH, El Haddad L, Hoffmann G, Copson E, Mayman S, Jose J, Lang S, Chen O, Dela Pena A, Levin E, Abdelbarr M, Slyne A, ElMallah MK. PPMO-based exon skipping therapy improves respiratory function in the mdx mouse model of Duchenne muscular dystrophy. Mol Ther Nucleic Acids. 2025 Dec 26;37(1):102810. doi: 10.1016/j.omtn.2025.102810. PMID: 41552386; PMCID: PMC12809079.

Stereocontrolled Synthesis of Dimethylamino Phosphorochloridate Monomers toward Stereopure Phosphorodiamidate Morpholino Oligonucleotides

Authors:
Inutake R, Hasegawa H, Tsurusaki T, Sakamoto T, Sato K, Wada T
Citation:
J Org Chem. 2026 Mar 11. doi: 10.1021/acs.joc.5c02914. Epub ahead of print. PMID: 41814639
Epub:
Not Epub
Abstract:
As antisense oligonucleotides, phosphorodiamidate morpholino oligonucleotides (PMOs) exhibit excellent properties. However,...
Link:
https://pubs.acs.org/doi/10.1021/acs.joc.5c02914
Delivery Method:
None
Organism or Cell Type:
None
Citation Extract:
Inutake R, Hasegawa H, Tsurusaki T, Sakamoto T, Sato K, Wada T. Stereocontrolled Synthesis of Dimethylamino Phosphorochloridate Monomers toward Stereopure Phosphorodiamidate Morpholino Oligonucleotides. J Org Chem. 2026 Mar 11. doi: 10.1021/acs.joc.5c02914. Epub ahead of print. PMID: 41814639.

Polysorbates' effects on molecular and thermodynamic properties of phosphorodiamidate morpholino oligonucleotides' structures

Authors:
Kliuchnikov E, Pierson D, Chou Y, DiLuzio W, Marx KA, Chanda A, Barsegov V
Citation:
Mol Ther Nucleic Acids. 2026 Jan 24;37(1):102845. doi: 10.1016/j.omtn.2026.102845. PMID: 41717288; PMCID: PMC12914542
Epub:
Not Epub
Abstract:
Elucidating the structure-function relationships of phosphorodiamidate morpholino oligonucleotides (PMOs) is challenging due to...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(26)00016-8
Delivery Method:
None
Organism or Cell Type:
None
Citation Extract:
Kliuchnikov E, Pierson D, Chou Y, DiLuzio W, Marx KA, Chanda A, Barsegov V. Polysorbates' effects on molecular and thermodynamic properties of phosphorodiamidate morpholino oligonucleotides' structures. Mol Ther Nucleic Acids. 2026 Jan 24;37(1):102845. doi: 10.1016/j.omtn.2026.102845. PMID: 41717288; PMCID: PMC12914542.

A novel zebrafish model unveils folate deficiency disrupts embryonic development via p53-driven cell cycle arrest

Authors:
Zhu K, Liu H, Zhou K, Cheng T, Mo L, Xu PF, Li Y
Citation:
J Adv Res. 2026 Mar 5:S2090-1232(26)00188-8. doi: 10.1016/j.jare.2026.02.054. Epub ahead of print. PMID: 41794221
Epub:
Not Epub
Abstract:
Introduction: Folate (vitamin B9) is a fundamental cofactor in one-carbon metabolism, essential for embryonic development....
Link:
https://www.sciencedirect.com/science/article/pii/S2090123226001888
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhu K, Liu H, Zhou K, Cheng T, Mo L, Xu PF, Li Y. A novel zebrafish model unveils folate deficiency disrupts embryonic development via p53-driven cell cycle arrest. J Adv Res. 2026 Mar 5:S2090-1232(26)00188-8. doi: 10.1016/j.jare.2026.02.054. Epub ahead of print. PMID: 41794221.

Microbe-associated molecular patterns differentially mediate carcinogenic alterations of the breast tissue in the context of obesity

Authors:
Gaber M, Moulden LM, Wilson AS, Payne V, Holmes J, Neary K, Peoples A, Duet ML, Katz AJ, Vidi PA, Cook KL
Citation:
Neoplasia. 2026 Mar;73:101284. doi: 10.1016/j.neo.2026.101284. Epub 2026 Feb 17. PMID: 41707315; PMCID: PMC12925586
Epub:
Not Epub
Abstract:
Obesity is a risk factor for breast cancer. Obesity alters the microbiome and microbiome perturbations are reported in breast...
Link:
https://www.sciencedirect.com/science/article/pii/S1476558626000138
Delivery Method:
intraperitoneal (i.p.) injection
Organism or Cell Type:
C57BL/6 mice
Citation Extract:
Gaber M, Moulden LM, Wilson AS, Payne V, Holmes J, Neary K, Peoples A, Duet ML, Katz AJ, Vidi PA, Cook KL. Microbe-associated molecular patterns differentially mediate carcinogenic alterations of the breast tissue in the context of obesity. Neoplasia. 2026 Mar;73:101284. doi: 10.1016/j.neo.2026.101284. Epub 2026 Feb 17. PMID: 41707315; PMCID: PMC12925586.

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