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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12455 scientific papers returned from the database with the search filters currently being used below.

Robust and stable transcriptional repression in Giardia using CRISPRi

Authors:
McInally SG, Hagen KD, Nosala C, Williams J, Nguyen K, Booker J, Jones K, Dawson SC
Citation:
BioRXive. 2018;358598. doi:10.1101/358598
Epub:
Not Epub
Abstract:
Giardia lamblia is a binucleate protistan parasite causing significant diarrheal disease worldwide. An inability to target Cas9...
Link:
https://www.biorxiv.org/content/early/2018/09/28/358598
Delivery Method:
electroporation
Organism or Cell Type:
Giardia lamblia
Citation Extract:
McInally SG, Hagen KD, Nosala C, Williams J, Nguyen K, Booker J, Jones K, Dawson SC. Robust and stable transcriptional repression in Giardia using CRISPRi. BioRXive. 2018;358598. doi:10.1101/358598.

A flow platform for degradation-free CuAAC bioconjugation

Authors:
Hatit MZC, Reichenbach LF, Tobin JM, Vilela F, Burley GA, Watson AJB
Citation:
Nat Comm. 2018;9:4021. doi:10.1038/s41467-018-06551-0
Epub:
Not Epub
Abstract:
The Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a cornerstone method for the ligation of biomolecules. However...
Link:
https://www.nature.com/articles/s41467-018-06551-0
Citation Extract:
Hatit MZC, Reichenbach LF, Tobin JM, Vilela F, Burley GA, Watson AJB. A flow platform for degradation-free CuAAC bioconjugation. Nat Comm. 2018;9:4021. doi:10.1038/s41467-018-06551-0.

Meis transcription factor maintains the neurogenic ectoderm and regulates the anterior-posterior patterning in embryos of a sea urchin, Hemicentrotus pulcherrimus

Authors:
Yaguchi J, Yamazaki A, Yaguchi S
Citation:
Dev Biol. 2018 Sep 25. pii: S0012-1606(18)30428-7. doi: 10.1016/j.ydbio.2018.09.018. [Epub ahead of print]
Epub:
Yes
Abstract:
Precise body axis formation is an essential step in the development of multicellular organisms, for most of which the molecular...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160618304287
Delivery Method:
microinjection
Organism or Cell Type:
Hemicentrotus pulcherrimus (sea urchin)
Citation Extract:
Yaguchi J, Yamazaki A, Yaguchi S. Meis transcription factor maintains the neurogenic ectoderm and regulates the anterior-posterior patterning in embryos of a sea urchin, Hemicentrotus pulcherrimus. Dev Biol. 2018 Sep 25. pii: S0012-1606(18)30428-7. doi: 10.1016/j.ydbio.2018.09.018. [Epub ahead of print].

Loss of Leucyl-tRNA synthetase b leads to ILFS1-like symptoms in zebrafish

Authors:
Wang Z, Song J, Luo L, Ma J
Citation:
Biochem Biophys Res Commun. 2018 Sep 24. pii: S0006-291X(18)32067-9. doi: 10.1016/j.bbrc.2018.09.133. [Epub ahead of print]
Epub:
Yes
Abstract:
Leucyl-tRNA synthetase (LARS) is a kind of aminoacyl-tRNA synthetases (aaRSs), which is important for protein synthesis....
Link:
https://www.sciencedirect.com/science/article/pii/S0006291X18320679
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wang Z, Song J, Luo L, Ma J. Loss of Leucyl-tRNA synthetase b leads to ILFS1-like symptoms in zebrafish. Biochem Biophys Res Commun. 2018 Sep 24. pii: S0006-291X(18)32067-9. doi: 10.1016/j.bbrc.2018.09.133. [Epub ahead of print].

Cell type-specific expression profiling unravels the development and evolution of stinging cells in sea anemone

Authors:
Sunagar K, Columbus-Shenkar YY, Fridrich A, Gutkovich N, Aharoni R, Moran Y
Citation:
BMC Biology. 2018;16:108. doi:10.1186/s12915-018-0578-4
Epub:
Not Epub
Abstract:
Background: Cnidocytes are specialized cells that define the phylum Cnidaria. They possess an "explosive" organelle...
Link:
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0578-4
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Sunagar K, Columbus-Shenkar YY, Fridrich A, Gutkovich N, Aharoni R, Moran Y. Cell type-specific expression profiling unravels the development and evolution of stinging cells in sea anemone. BMC Biology. 2018;16:108. doi:10.1186/s12915-018-0578-4.

Implementing Morpholino-Based Nucleic Acid Sensing on a Portable Surface Plasmon Resonance Instrument for Future Application in Environmental Monitoring

Authors:
Bagi A, Soelberg SD, Furlong CE, Baussant T
Citation:
Sensors. 2018;18(10):3259. doi:10.3390/s18103259
Epub:
Not Epub
Abstract:
A portable surface plasmon resonance (SPR) instrument was tested for the first time for the detection of oligonucleotide...
Link:
https://www.mdpi.com/1424-8220/18/10/3259
Citation Extract:
Bagi A, Soelberg SD, Furlong CE, Baussant T. Implementing Morpholino-Based Nucleic Acid Sensing on a Portable Surface Plasmon Resonance Instrument for Future Application in Environmental Monitoring. Sensors. 2018;18(10):3259. doi:10.3390/s18103259.

Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration

Authors:
Bangru S, Arif W, Seimetz J, Bhate A, Chen J, Rashan EH, Carstens RP, Anakk S, Kalsotra A
Citation:
Nature Struct & Molec Biol. 2018;[epub ahead of print] doi:10.1038/s41594-018-0129-2
Epub:
Yes
Abstract:
During liver regeneration, most new hepatocytes arise via self-duplication; yet, the underlying mechanisms that drive...
Link:
https://www.nature.com/articles/s41594-018-0129-2
Organism or Cell Type:
cell culture: AML-12
Citation Extract:
Bangru S, Arif W, Seimetz J, Bhate A, Chen J, Rashan EH, Carstens RP, Anakk S, Kalsotra A. Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration. Nature Struct & Molec Biol. 2018;[epub ahead of print] doi:10.1038/s41594-018-0129-2.

Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo

Authors:
Kotini M, Barriga EH, Leslie J, Gentzel M, Rauschenberger V, Schambon A, Mayor R
Citation:
Nat Commun. 2018 Sep 21;9(1):3846. doi: 10.1038/s41467-018-06368-x
Epub:
Not Epub
Abstract:
Connexins are the primary components of gap junctions, providing direct links between cells under many physiological processes...
Link:
https://www.nature.com/articles/s41467-018-06368-x
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kotini M, Barriga EH, Leslie J, Gentzel M, Rauschenberger V, Schambon A, Mayor R. Gap junction protein Connexin-43 is a direct transcriptional regulator of N-cadherin in vivo. Nat Commun. 2018 Sep 21;9(1):3846. doi: 10.1038/s41467-018-06368-x.

Expression and function of lncRNA MALAT-1 in the embryonic development of zebrafish

Authors:
Wu M, Zhang S, Chen X, Xu H, Li X
Citation:
Gene. 2018 Sep 21. pii: S0378-1119(18)30996-X. doi: 10.1016/j.gene.2018.09.037. [Epub ahead of print]
Epub:
Yes
Abstract:
Long non-coding RNAs (lncRNAs) are RNA molecules with a transcript length of >200 nt which do not encode proteins, however,...
Link:
https://www.sciencedirect.com/science/article/pii/S037811191830996X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wu M, Zhang S, Chen X, Xu H, Li X. Expression and function of lncRNA MALAT-1 in the embryonic development of zebrafish. Gene. 2018 Sep 21. pii: S0378-1119(18)30996-X. doi: 10.1016/j.gene.2018.09.037. [Epub ahead of print].

CTP synthase knockdown during early development distorts the nascent vertebral column and causes fluid retention in multiple tissues in zebrafish

Authors:
Dzaki N, Wahab W, Azlan A, Azzam G
Citation:
Biochem Biophys Res Commun. 2018 Sep 18. pii: S0006-291X(18)31999-5. doi: 10.1016/j.bbrc.2018.09.074. [Epub ahead of print]
Epub:
Yes
Abstract:
CTP Synthase (CTPS) is a metabolic enzyme that is recognized as a catalyst for nucleotide, phospholipid and sialoglycoprotein...
Link:
https://www.sciencedirect.com/science/article/pii/S0006291X18319995
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dzaki N, Wahab W, Azlan A, Azzam G. CTP synthase knockdown during early development distorts the nascent vertebral column and causes fluid retention in multiple tissues in zebrafish. Biochem Biophys Res Commun. 2018 Sep 18. pii: S0006-291X(18)31999-5. doi: 10.1016/j.bbrc.2018.09.074. [Epub ahead of print].

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