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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12557 scientific papers returned from the database with the search filters currently being used below.

De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance

Authors:
Häkkinen H, Batet M, Bianchi LF, Jiménez-Delgado S, Pezzano F, Wieser S, Hoijman E, Vibe C, Wijma S, Ruprecht V
Citation:
bioRxiv [preprint] 2025.12.08.692667; doi: https://doi.org/10.64898/2025.12.08.692667
Epub:
Not Epub
Abstract:
Beyond serving as cohesive barriers, epithelial tissues are involved in tissue surveillance and actively clear apoptotic cells...
Link:
https://www.biorxiv.org/content/10.64898/2025.12.08.692667v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Häkkinen H, Batet M, Bianchi LF, Jiménez-Delgado S, Pezzano F, Wieser S, Hoijman E, Vibe C, Wijma S, Ruprecht V. De novo E-cadherin/catenin complex formation controls basal epithelial mechanics and force transmission for apoptotic cell clearance. bioRxiv [preprint] 2025.12.08.692667; doi: https://doi.org/10.64898/2025.12.08.692667.

Prpf4 sequentially regulates the expansion and maturation of erythrocyte through distinct mechanisms

Authors:
Deng Z, Huang S, Pei Y, Li H, Dong Y, Li Y, Ran Q, Liu X, Feng Y, Wang Q, Guo Z, Huang S
Citation:
Cell Death Discov. 2025 Dec 8;11(1):555. doi: 10.1038/s41420-025-02846-6. PMID: 41360772; PMCID: PMC12686395
Epub:
Not Epub
Abstract:
The proliferation of early erythrocyte and the subsequent maturation are critical events during erythropoiesis, while how these...
Link:
https://www.nature.com/articles/s41420-025-02846-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Deng Z, Huang S, Pei Y, Li H, Dong Y, Li Y, Ran Q, Liu X, Feng Y, Wang Q, Guo Z, Huang S. Prpf4 sequentially regulates the expansion and maturation of erythrocyte through distinct mechanisms. Cell Death Discov. 2025 Dec 8;11(1):555. doi: 10.1038/s41420-025-02846-6. PMID: 41360772; PMCID: PMC12686395.

Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome

Authors:
Nielsen T, Kervadec A, Theis JL, Missinato MA, Marchant J, Romero M, Marchetti K, Lamba A, Zeng XI, Berenguer M, Walls SM, Schroeder A, Birker K, Duester G, Grossfeld P, Nelson TJ, Olson TM, Ocorr K, Bodmer R, Vogler G, Colas AR
Citation:
Elife. 2025 Dec 11;14:RP106231. doi: 10.7554/eLife.106231. PMID: 41379537; PMCID: PMC12698088
Epub:
Not Epub
Abstract:
Hypoplastic left heart syndrome (HLHS) is the most lethal congenital heart disease (CHD) whose genetic basis remains elusive,...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12698088/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nielsen T, Kervadec A, Theis JL, Missinato MA, Marchant J, Romero M, Marchetti K, Lamba A, Zeng XI, Berenguer M, Walls SM, Schroeder A, Birker K, Duester G, Grossfeld P, Nelson TJ, Olson TM, Ocorr K, Bodmer R, Vogler G, Colas AR. Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome. Elife. 2025 Dec 11;14:RP106231. doi: 10.7554/eLife.106231. PMID: 41379537; PMCID: PMC12698088.

Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion

Authors:
Hayes MI, Ravishankar S, Shanahan JK, Fountain AJ, Ramakrishnan L, Madigan CA
Citation:
Cell Rep. 2025 Dec 10;44(12):116661. doi: 10.1016/j.celrep.2025.116661. Epub ahead of print. PMID: 41385366
Epub:
Not Epub
Abstract:
Tuberculous meningitis is unique among bacterial meningitides because it occurs in two temporally separated steps: mycobacteria...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)01433-0
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Hayes MI, Ravishankar S, Shanahan JK, Fountain AJ, Ramakrishnan L, Madigan CA. Mycobacteria trehalose dimycolate interactions with host Mincle remodel blood-brain barrier junctions for brain invasion. Cell Rep. 2025 Dec 10;44(12):116661. doi: 10.1016/j.celrep.2025.116661. Epub ahead of print. PMID: 41385366.

Cohesin protein Smc3 influences kinocilial structure and function

Authors:
Mensching FM, Banoukh N, Iovine MK
Citation:
Biol Open. 2025 Dec 15;14(12):bio062029. doi: 10.1242/bio.062029. Epub 2025 Dec 11. PMID: 41263044
Epub:
Not Epub
Abstract:
Cohesinopathies and ciliopathies are congenital disorders affecting overlapping body systems. The extent to which these...
Link:
https://journals.biologists.com/bio/article/14/12/bio062029/370085/Cohesin-protein-Smc3-influences-kinocilial
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Mensching FM, Banoukh N, Iovine MK. Cohesin protein Smc3 influences kinocilial structure and function. Biol Open. 2025 Dec 15;14(12):bio062029. doi: 10.1242/bio.062029. Epub 2025 Dec 11. PMID: 41263044.

Positive modulation of sigma-1 receptor: a new weapon to mitigate disease progression in amyotrophic lateral sclerosis

Authors:
Le Friec J, Mourier H, Couly S, Cubedo N, Dubois K, Meunier J, Delprat B, De Zordo-Banliat A, Ayad T, Virieux D, Su TP, Lasbleiz C, Maurice T, Liévens JC
Citation:
Transl Neurodegener. 2025 Dec 15;14(1):68. doi: 10.1186/s40035-025-00527-z. PMID: 41392158; PMCID: PMC12703938
Epub:
Not Epub
Abstract:
Background: Amyotrophic lateral sclerosis (ALS) is characterised by degeneration of motor neurons, leading to muscle weakness...
Link:
https://link.springer.com/article/10.1186/s40035-025-00527-z
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Le Friec J, Mourier H, Couly S, Cubedo N, Dubois K, Meunier J, Delprat B, De Zordo-Banliat A, Ayad T, Virieux D, Su TP, Lasbleiz C, Maurice T, Liévens JC. Positive modulation of sigma-1 receptor: a new weapon to mitigate disease progression in amyotrophic lateral sclerosis. Transl Neurodegener. 2025 Dec 15;14(1):68. doi: 10.1186/s40035-025-00527-z. PMID: 41392158; PMCID: PMC12703938.

A novel and critical role of the intracellular Zona Pellucida protein 2 (ZP2) for blastocyst formation in mice

Authors:
Nolte T, Israel S, Drexler HCA, Fuellen G, Boiani M
Citation:
bioRxiv [preprint] 2025.12.12.692802; doi: https://doi.org/10.64898/2025.12.12.692802
Epub:
Not Epub
Abstract:
The zona pellucida (ZP) is the quintessential extracellular structure of mammalian oocytes. Contrary to long-standing view that...
Link:
https://www.biorxiv.org/content/10.64898/2025.12.12.692802v1
Delivery Method:
microinjection
Organism or Cell Type:
mouse zygotes from B6C3F1 females mated to CD1 males
Citation Extract:
Nolte T, Israel S, Drexler HCA, Fuellen G, Boiani M. A novel and critical role of the intracellular Zona Pellucida protein 2 (ZP2) for blastocyst formation in mice. bioRxiv [preprint] 2025.12.12.692802; doi: https://doi.org/10.64898/2025.12.12.692802.

In vivo imaging reveals exosome-mediated intercellular communication in lens development

Authors:
Ma J, Sun Q, Chen Y, Li J, Ouyang S, Ke S, Li J, Liang H, Chen S, Luo L
Citation:
Commun Biol 8, 1774 (2025). https://doi.org/10.1038/s42003-025-09159-5
Epub:
Not Epub
Abstract:
Lens transparency relies on proper intercellular communication. Exosomes are crucial mediators of intercellular communication...
Link:
https://www.nature.com/articles/s42003-025-09159-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ma J, Sun Q, Chen Y, Li J, Ouyang S, Ke S, Li J, Liang H, Chen S, Luo L. In vivo imaging reveals exosome-mediated intercellular communication in lens development. Commun Biol 8, 1774 (2025). https://doi.org/10.1038/s42003-025-09159-5.

Suppression of brain aromatase decreases the expression of dopaminergic neuron in early development of zebrafish

Authors:
Fatimah R, Ulhaq ZS, Rafiuddin MA, Kishida M
Citation:
Fish Physiol Biochem. 2025 Dec 13;51(6):204. doi: 10.1007/s10695-025-01620-w. PMID: 41389094
Epub:
Not Epub
Abstract:
Cytochrome P450 aromatase, the product of the CYP19A1 gene, is a key enzyme in estrogen biosynthesis. Most teleost fish have...
Link:
https://link.springer.com/article/10.1007/s10695-025-01620-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Fatimah R, Ulhaq ZS, Rafiuddin MA, Kishida M. Suppression of brain aromatase decreases the expression of dopaminergic neuron in early development of zebrafish. Fish Physiol Biochem. 2025 Dec 13;51(6):204. doi: 10.1007/s10695-025-01620-w. PMID: 41389094.

Pathogenic Mechanism of the KCNQ4 Gene Variant in Hearing Loss and Functional Validation in a Zebrafish Model

Authors:
Jia H, Liu X, Chen H, Wang Y, Guan MX, Guo Y
Citation:
FASEB J. 2025 Dec 15;39(23):e71274. doi: 10.1096/fj.202500557R. PMID: 41368761
Epub:
Not Epub
Abstract:
The KCNQ4 gene is closely associated with autosomal dominant nonsyndromic hearing loss (DFNA2) and encodes a potassium channel...
Link:
https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202500557R
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Jia H, Liu X, Chen H, Wang Y, Guan MX, Guo Y. Pathogenic Mechanism of the KCNQ4 Gene Variant in Hearing Loss and Functional Validation in a Zebrafish Model. FASEB J. 2025 Dec 15;39(23):e71274. doi: 10.1096/fj.202500557R. PMID: 41368761.

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