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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12437 scientific papers returned from the database with the search filters currently being used below.

Foxi1 regulates multiple steps of mucociliary development and ionocyte specification through transcriptional and epigenetic mechanisms

Authors:
Bowden S, Brislinger-Engelhardt MM, Hansen M, Temporal-Plo A, Weber D, Hägele S, Lorenz F, Litwin T, Kreutz C, Walentek P
Citation:
bioRxiv [Preprint]. 2024 Nov 4:2024.10.27.620464. doi: 10.1101/2024.10.27.620464. PMID: 39484493; PMCID: PMC11527170
Epub:
Not Epub
Abstract:
Foxi1 is a master regulator of ionocytes (ISCs / INCs) across species and organs. Two subtypes of ISCs exist, and both α- and β...
Link:
https://www.biorxiv.org/content/10.1101/2024.10.27.620464v3.full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Bowden S, Brislinger-Engelhardt MM, Hansen M, Temporal-Plo A, Weber D, Hägele S, Lorenz F, Litwin T, Kreutz C, Walentek P. Foxi1 regulates multiple steps of mucociliary development and ionocyte specification through transcriptional and epigenetic mechanisms. bioRxiv [Preprint]. 2024 Nov 4:2024.10.27.620464. doi: 10.1101/2024.10.27.620464. PMID: 39484493; PMCID: PMC11527170.

ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis

Authors:
Chen W, Wu J, She P, Li J, Lan Y, Hu X, Huangfu Y, Wu C, Jin D, Xie P, Zhuang G, Wu Y, Zhang Y, Zon LI, Zhu P, Zhong TP
Citation:
Nat Commun. 2025 Jul 16;16(1):6550. doi: 10.1038/s41467-025-61680-7. PMID: 40670340; PMCID: PMC12267628
Epub:
Not Epub
Abstract:
T lymphocytes, which are essential for cell-mediated immunity in vertebrates, rely on thymic seeding of lymphoid progenitors...
Link:
https://www.nature.com/articles/s41467-025-61680-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen W, Wu J, She P, Li J, Lan Y, Hu X, Huangfu Y, Wu C, Jin D, Xie P, Zhuang G, Wu Y, Zhang Y, Zon LI, Zhu P, Zhong TP. ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis. Nat Commun. 2025 Jul 16;16(1):6550. doi: 10.1038/s41467-025-61680-7. PMID: 40670340; PMCID: PMC12267628.

ZSCAN4 functions as a safeguard to maintain centromere integrity during oocyte meiosis

Authors:
Choi DY, Leem J, Lee C, Oh JS
Citation:
Genome Biol. 2025 Jul 15;26(1):204. doi: 10.1186/s13059-025-03687-3. PMID: 40665375; PMCID: PMC12261598
Epub:
Not Epub
Abstract:
Background: Centromeres play a vital role in ensuring accurate chromosome segregation during meiosis by serving as the...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12261598/
Delivery Method:
microinjection
Organism or Cell Type:
CD1 mouse oocysts
Citation Extract:
Choi DY, Leem J, Lee C, Oh JS. ZSCAN4 functions as a safeguard to maintain centromere integrity during oocyte meiosis. Genome Biol. 2025 Jul 15;26(1):204. doi: 10.1186/s13059-025-03687-3. PMID: 40665375; PMCID: PMC12261598.

Transient versican expression is required for β1-Integrin accumulation during podocyte layer morphogenesis in amphibian developing kidney

Authors:
Buisson I, Riou JF, Umbhauer M, Le Bouffant R, Bello V
Citation:
bioRxiv [preprint] 2025.07.20.665792; doi: https://doi.org/10.1101/2025.07.20.665792
Epub:
Not Epub
Abstract:
The functional organization of the vertebrate nephron is remarkably conserved. However, the morphogenetic processes underlying...
Link:
https://www.biorxiv.org/content/10.1101/2025.07.20.665792v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Buisson I, Riou JF, Umbhauer M, Le Bouffant R, Bello V. Transient versican expression is required for β1-Integrin accumulation during podocyte layer morphogenesis in amphibian developing kidney. bioRxiv [preprint] 2025.07.20.665792; doi: https://doi.org/10.1101/2025.07.20.665792.

Using muscle homing peptide CyPep10 to deliver phosphorodiamidate morpholino oligomers in the mdx mouse

Authors:
Schneider A-FE, Tanganyika-de Winter CL, Jirka SMG, Tan X, Thompson EG, Ha K, Mitra A, Garcia S, Luimes M, Oliver RA, Guerlavais V, Aartsma-Rus A
Citation:
Molecular Therapy - Nucleic Acids (2025), doi: https://doi.org/10.1016/j.omtn.2025.102625
Epub:
Not Epub
Abstract:
The severe muscle wasting disorder Duchenne muscular dystrophy (DMD) is characterized by the absence of dystrophin, a protein...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(25)00179-9
Delivery Method:
CP10 and acetyl-R6Gly peptide-linked; intravenous (i.v.)
Organism or Cell Type:
mdx mice
Citation Extract:
Schneider A-FE, Tanganyika-de Winter CL, Jirka SMG, Tan X, Thompson EG, Ha K, Mitra A, Garcia S, Luimes M, Oliver RA, Guerlavais V, Aartsma-Rus A. Using muscle homing peptide CyPep10 to deliver phosphorodiamidate morpholino oligomers in the mdx mouse. Molecular Therapy - Nucleic Acids (2025), doi: https://doi.org/10.1016/j.omtn.2025.102625.

Prdx6 regulates in vivo myeloid cell development via redox control during Xenopus embryogenesis

Authors:
Kim M, Lee HK, Lee H, Lee HS
Citation:
Anim Cells Syst (Seoul). 2025 Jul 16;29(1):438-445. doi: 10.1080/19768354.2025.2533823. PMID: 40677760; PMCID: PMC12269089
Epub:
Not Epub
Abstract:
Peroxiredoxin6 (Prdx6) is a bifunctional antioxidant enzyme with both peroxidase and phospholipase A₂ activities. Although its...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12269089/
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim M, Lee HK, Lee H, Lee HS. Prdx6 regulates in vivo myeloid cell development via redox control during Xenopus embryogenesis. Anim Cells Syst (Seoul). 2025 Jul 16;29(1):438-445. doi: 10.1080/19768354.2025.2533823. PMID: 40677760; PMCID: PMC12269089.

Perfluorodecanesulfonate (PFDS) induces innate immune toxicity through the NF-κB pathway in early life stage zebrafish

Authors:
Zhou C, Chen W, Xuan R, Kang X, Wang J, Magnuson JT, Li J, Fang D, Qiu W
Citation:
Environ Int. 2025 Jul 16;202:109688. doi: 10.1016/j.envint.2025.109688. Epub ahead of print. PMID: 40683240
Epub:
Not Epub
Abstract:
Perfluorodecanesulfonate (PFDS), a long-chain polyfluoroalkyl substance (PFAS), is widely detected in aquatic environments and...
Link:
https://www.sciencedirect.com/science/article/pii/S0160412025004398
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhou C, Chen W, Xuan R, Kang X, Wang J, Magnuson JT, Li J, Fang D, Qiu W. Perfluorodecanesulfonate (PFDS) induces innate immune toxicity through the NF-κB pathway in early life stage zebrafish. Environ Int. 2025 Jul 16;202:109688. doi: 10.1016/j.envint.2025.109688. Epub ahead of print. PMID: 40683240.

Insights into the evolution and regulation of hybrid internal-terminal exons from tropomyosin exon 9A in Xenopus laevis

Authors:
Méreau A, Lerivray H, Viet J, Hardy S, Paillard L, Audic Y
Citation:
Biochimie. 2025 Jul 9:S0300-9084(25)00150-6. doi: 10.1016/j.biochi.2025.07.009. Epub ahead of print. PMID: 40645271
Epub:
Not Epub
Abstract:
Hybrid internal-terminal exons function as either internal or terminal exons. Their evolutionary origins remain unclear. Here,...
Link:
https://www.sciencedirect.com/science/article/pii/S0300908425001506
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Méreau A, Lerivray H, Viet J, Hardy S, Paillard L, Audic Y. Insights into the evolution and regulation of hybrid internal-terminal exons from tropomyosin exon 9A in Xenopus laevis. Biochimie. 2025 Jul 9:S0300-9084(25)00150-6. doi: 10.1016/j.biochi.2025.07.009. Epub ahead of print. PMID: 40645271.

Proof-of-concept for sterility induction in sablefish (Anoplopoma fimbria) via a scalable immersion-based gene silencing approach

Authors:
Yanagitsuru YR, Hayman ES, Fairgrieve WT, Zohar Y, Wong T-T, Luckenbach JA
Citation:
Aquaculture. 9 July 2025
Epub:
Not Epub
Abstract:
Genetic introgression and loss of fitness in wild populations due to escape of farmed fish are major sustainability concerns in...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0044848625008312
Delivery Method:
Vivo-Morpholino bathing
Organism or Cell Type:
Anoplopoma fimbria (sablefish)
Citation Extract:
Yanagitsuru YR, Hayman ES, Fairgrieve WT, Zohar Y, Wong T-T, Luckenbach JA. Proof-of-concept for sterility induction in sablefish (Anoplopoma fimbria) via a scalable immersion-based gene silencing approach. Aquaculture. 9 July 2025.

Development of a two-dimensional liquid chromatography/mass spectrometry workflow for characterization of phosphorodiamidate morpholino oligomers

Authors:
Wei T, Wang M, Cai BZ
Citation:
J Chromatogr A. 2025 Jun 6;1757:466129. doi: 10.1016/j.chroma.2025.466129. Epub ahead of print. PMID: 40516491
Epub:
Not Epub
Abstract:
A sensitive two-dimensional liquid chromatography/mass spectrometry (2D-LC/MS) workflow was developed for characterization of...
Link:
https://www.sciencedirect.com/science/article/pii/S0021967325004753
Delivery Method:
none
Organism or Cell Type:
none
Citation Extract:
Wei T, Wang M, Cai BZ. Development of a two-dimensional liquid chromatography/mass spectrometry workflow for characterization of phosphorodiamidate morpholino oligomers. J Chromatogr A. 2025 Jun 6;1757:466129. doi: 10.1016/j.chroma.2025.466129. Epub ahead of print. PMID: 40516491.

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