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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12184 scientific papers returned from the database with the search filters currently being used below.

Discovery and characterization of stereodefined PMO-gapmers targeting tau

Authors:
Kanatsu K, Takahashi Y, Sakaguchi T, Kim DS, Murota M, Shan M, Fukami K, Itano W, Kikuta K, Yoshimura H, Kurokawa T, Nagayama Y, Ishikawa R, Dairiki R, Zhou Z, Sanders K, Stupalski J, Yasui S, Liu D, Benayoud F, Fang H, Jing E, Ogo M, Fang FG, Wang J, Choi HW
Citation:
Mol Ther Nucleic Acids. 2024 Nov 28;36(1):102404. doi: 10.1016/j.omtn.2024.102404. PMID: 39759873; PMCID: PMC11699249
Epub:
Not Epub
Abstract:
Antisense oligonucleotides (ASOs) are an important class of therapeutics to treat genetic diseases, and expansion of this...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11699249/
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: SH-SY5Y
Citation Extract:
Kanatsu K, Takahashi Y, Sakaguchi T, Kim DS, Murota M, Shan M, Fukami K, Itano W, Kikuta K, Yoshimura H, Kurokawa T, Nagayama Y, Ishikawa R, Dairiki R, Zhou Z, Sanders K, Stupalski J, Yasui S, Liu D, Benayoud F, Fang H, Jing E, Ogo M, Fang FG, Wang J, Choi HW. Discovery and characterization of stereodefined PMO-gapmers targeting tau. Mol Ther Nucleic Acids. 2024 Nov 28;36(1):102404. doi: 10.1016/j.omtn.2024.102404. PMID: 39759873; PMCID: PMC11699249.

Enhancing Peptide and PMO Delivery to Mouse Airway Epithelia by Chemical Conjugation with the Amphiphilic Peptide S10

Authors:
Auger M, Sorroza-Martinez L, Brahiti N, Huppé C-A, Faucher-Giguère L, Arbi I, Hervault M, Cheng X, Gaillet B, Couture F, Guay D, Soultan A-H
Citation:
Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102290
Epub:
Not Epub
Abstract:
Delivery of antisense oligonucleotides (ASOs) to airway epithelial cells is arduous due to the physiological barriers that...
Link:
https://www.sciencedirect.com/science/article/pii/S216225312400177X
Delivery Method:
intranasal peptide-linked
Organism or Cell Type:
HeLa EGFP-654 cells; CAG-EGFP-654 mice
Citation Extract:
Auger M, Sorroza-Martinez L, Brahiti N, Huppé C-A, Faucher-Giguère L, Arbi I, Hervault M, Cheng X, Gaillet B, Couture F, Guay D, Soultan A-H. Enhancing Peptide and PMO Delivery to Mouse Airway Epithelia by Chemical Conjugation with the Amphiphilic Peptide S10. Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102290.

Tailored antisense oligonucleotides designed to correct aberrant splicing reveal actionable groups of mutations for rare genetic disorders

Authors:
Wai HA, Svobodova E, Herrera NR, Douglas AGL, Holloway JW, Baralle FE, Baralle M, Baralle D
Citation:
Exp Mol Med (2024). https://doi.org/10.1038/s12276-024-01292-1
Epub:
Not Epub
Abstract:
Effective translation of rare disease diagnosis knowledge into therapeutic applications is achievable within a reasonable...
Link:
https://www.nature.com/articles/s12276-024-01292-1
Delivery Method:
Vivo-Morpholinos, bare Morpholinos, Endo-Porter
Organism or Cell Type:
HEK293 cells
Citation Extract:
Wai HA, Svobodova E, Herrera NR, Douglas AGL, Holloway JW, Baralle FE, Baralle M, Baralle D. Tailored antisense oligonucleotides designed to correct aberrant splicing reveal actionable groups of mutations for rare genetic disorders. Exp Mol Med (2024). https://doi.org/10.1038/s12276-024-01292-1.

Cdon is essential for organ left-right patterning by regulating dorsal forerunner cells clustering and Kupffer's vesicle morphogenesis

Authors:
Deng Z, Ran Q, Chang W, Li C, Li B, Huang S, Huang J, Zhang K, Li Y, Liu X, Liang Y, Guo Z, Huang S
Citation:
Front Cell Dev Biol. 2024 Aug 22;12:1429782. doi: 10.3389/fcell.2024.1429782. PMID: 39239564; PMCID: PMC11374761
Epub:
Not Epub
Abstract:
Cdon and boc are members of the cell adhesion molecule subfamily III Ig/fibronectin. Although they have been reported to be...
Link:
https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2024.1429782/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Deng Z, Ran Q, Chang W, Li C, Li B, Huang S, Huang J, Zhang K, Li Y, Liu X, Liang Y, Guo Z, Huang S. Cdon is essential for organ left-right patterning by regulating dorsal forerunner cells clustering and Kupffer's vesicle morphogenesis. Front Cell Dev Biol. 2024 Aug 22;12:1429782. doi: 10.3389/fcell.2024.1429782. PMID: 39239564; PMCID: PMC11374761.

Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish

Authors:
Chen J, Zhao W, Cao L, Martins RST, Canário AVM
Citation:
BMC Biol. 2024 Jul 29;22(1):163. doi: 10.1186/s12915-024-01961-7. PMID: 39075492; PMCID: PMC11288053
Epub:
Not Epub
Abstract:
BACKGROUND: Energy allocation between growth and reproduction determines puberty onset and fertility. In mammals, peripheral...
Link:
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-024-01961-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen J, Zhao W, Cao L, Martins RST, Canário AVM. Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biol. 2024 Jul 29;22(1):163. doi: 10.1186/s12915-024-01961-7. PMID: 39075492; PMCID: PMC11288053.

Leucine-Rich Repeat Kinase-2 Controls the Differentiation and Maturation of Oligodendrocytes in Mice and Zebrafish

Authors:
Filippini A, Cannone E, Mazziotti V, Carini G, Mutti V, Ravelli C, Gennarelli M, Schiavone M, Russo I
Citation:
Biomolecules. 2024; 14(7):870. https://doi.org/10.3390/biom14070870
Epub:
Not Epub
Abstract:
Leucine-rich repeat kinase-2 (LRRK2), a gene mutated in familial and sporadic Parkinson’s disease (PD), controls multiple...
Link:
https://www.mdpi.com/2218-273X/14/7/870
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Filippini A, Cannone E, Mazziotti V, Carini G, Mutti V, Ravelli C, Gennarelli M, Schiavone M, Russo I. Leucine-Rich Repeat Kinase-2 Controls the Differentiation and Maturation of Oligodendrocytes in Mice and Zebrafish. Biomolecules. 2024; 14(7):870. https://doi.org/10.3390/biom14070870.

SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function

Authors:
Ranjan G, Sehgal P, Scaria V, Sivasubbu S
Citation:
EMBO Rep. 2024 Nov;25(11):4950-4978. doi: 10.1038/s44319-024-00272-w. Epub 2024 Oct 2. PMID: 39358551; PMCID: PMC11549340
Epub:
Not Epub
Abstract:
In this study, we characterize a novel lncRNA-producing gene locus that we name Syntenic Cardiovascular Conserved Region-...
Link:
https://link.springer.com/article/10.1038/s44319-024-00272-w
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ranjan G, Sehgal P, Scaria V, Sivasubbu S. SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function. EMBO Rep. 2024 Nov;25(11):4950-4978. doi: 10.1038/s44319-024-00272-w. Epub 2024 Oct 2. PMID: 39358551; PMCID: PMC11549340.

Sall4 regulates downstream patterning genes during limb regeneration

Authors:
Erickson JR, Walker SE, Arenas Gomez C, Echeverri K
Citation:
Dev Biol. 2024 Jul 25:S0012-1606(24)00195-7. doi: 10.1016/j.ydbio.2024.07.015. Epub ahead of print. PMID: 39067503.
Epub:
Not Epub
Abstract:
Many salamanders can completely regenerate a fully functional limb. Limb regeneration is a carefully coordinated process...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160624001957
Delivery Method:
injection then electroporation
Organism or Cell Type:
Ambystoma mexicanum (Axolotl)
Citation Extract:
Erickson JR, Walker SE, Arenas Gomez C, Echeverri K. Sall4 regulates downstream patterning genes during limb regeneration. Dev Biol. 2024 Jul 25:S0012-1606(24)00195-7. doi: 10.1016/j.ydbio.2024.07.015. Epub ahead of print. PMID: 39067503..

Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin- and empagliflozin-induced arterial relaxation

Authors:
Forrester EA, Benítez-Angeles M, Redford KE, Rosenbaum T, Abbott GW, Barrese V, Dora K, Albert AP, Dannesboe J, Salles-Crawley I, Jepps TA, Greenwood IA
Citation:
Cardiovasc Res. 2024 Nov 25;120(14):1811-1824. doi: 10.1093/cvr/cvae156. PMID: 39056245; PMCID: PMC11587556
Epub:
Not Epub
Abstract:
Aims: Sodium/glucose transporter 2 (SGLT2 or SLC5A2) inhibitors lower blood glucose and are also approved treatments for heart...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11587556/
Delivery Method:
Lipofectamine 2000
Organism or Cell Type:
NHE1 knockout mouse explant: mesenteric arteries
Citation Extract:
Forrester EA, Benítez-Angeles M, Redford KE, Rosenbaum T, Abbott GW, Barrese V, Dora K, Albert AP, Dannesboe J, Salles-Crawley I, Jepps TA, Greenwood IA . Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin- and empagliflozin-induced arterial relaxation. Cardiovasc Res. 2024 Nov 25;120(14):1811-1824. doi: 10.1093/cvr/cvae156. PMID: 39056245; PMCID: PMC11587556.

CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression

Authors:
Baker CE, Marta AG, Zimmerman ND, Korade Z, Mathy NW, Wilton D, Simeone T, Kochvar A, Kramer KL, Stessman HAF, Shibata A
Citation:
Biomolecules. 2024; 14(8):914
Epub:
Not Epub
Abstract:
Carnitine palmitoyltransferase 2 (CPT2) is an inner mitochondrial membrane protein of the carnitine shuttle and is involved in...
Link:
https://www.mdpi.com/2218-273X/14/8/914
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Baker CE, Marta AG, Zimmerman ND, Korade Z, Mathy NW, Wilton D, Simeone T, Kochvar A, Kramer KL, Stessman HAF, Shibata A. CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression. Biomolecules. 2024; 14(8):914.

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