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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12376 scientific papers returned from the database with the search filters currently being used below.
There are 12376 scientific papers returned from the database with the search filters currently being used below.
Systemically delivered antisense oligomers upregulate gene expression in mouse tissues
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Citation:
Nat Biotechnol. 2002 Dec;20(12):1228-33 Epub:
Not Epub Abstract:
Systemically injected 2'-O-methoxyethyl (2'-O-MOE)-phosphorothioate and PNA-4K oligomers (peptide nucleic acid with... Delivery Method:
in vivo: injection Organism or Cell Type:
Mice: EGFP transgenic Citation Extract: Sazani P, Gemignani F, Kang SH, Maier MA, Manoharan M, Persmark M, Bortner D, Kole R. Systemically delivered antisense oligomers upregulate gene expression in mouse tissues. Nat Biotechnol. 2002 Dec;20(12):1228-33. |
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4
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Citation:
Nat Genet. 2006 Jun;38(6):674-81. Epub 2006 May 7 Epub:
Not Epub Abstract:
The molecular basis of nephronophthisis, the most frequent genetic cause of renal failure in children and young adults, and its... Delivery Method:
Microinjection Organism or Cell Type:
zebrafish Citation Extract: Sayer JA, Otto EA, O'toole JF, Nurnberg G, Kennedy MA, Becker C, Hennies HC, Helou J, Attanasio M, Fausett BV, Utsch B, Khanna H, Liu Y, Drummond I, Kawakami I, Kusakabe T, Tsuda M, Ma L, Lee H, Larson RG, Allen SJ, Wilkinson CJ, Nigg EA, Shou C, Lillo C, Williams DS, Hoppe B, Kemper MJ, Neuhaus T, Parisi MA, Glass IA, Petry M, Kispert A, Gloy J, Ganner A, Walz G, Zhu X, Goldman D, Nurnberg P, Swaroop A, Leroux MR, Hildebrandt F. The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet. 2006 Jun;38(6):674-81. Epub 2006 May 7. |
The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development
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Citation:
Cell. 2008 May 2;133(3):486-97 Epub:
Not Epub Abstract:
During development of multicellular organisms, cells respond to extracellular cues through nonlinear signal transduction... Organism or Cell Type:
zebrafish Citation Extract: Schenck A, Goto-Silva L, Collinet C, Rhinn M, Giner A, Habermann B, Brand M, Zerial M. The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell. 2008 May 2;133(3):486-97. |
The kinesin KIF1B{beta} acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor
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Citation:
Genes Dev. 2008 Apr 1;22(7):884-93. Epub 2008 Mar 11 Epub:
Not Epub Abstract:
VHL, NF-1, c-Ret, and Succinate Dehydrogenase Subunits B and D act on a developmental apoptotic pathway that is activated when... Delivery Method:
Microinjection Organism or Cell Type:
zebrafish Citation Extract: Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, Shahriari K, Nguyen NV, Pigny P, Dahia PL, Pomeroy SL, Maris JM, Look AT, Meyerson M, Peeper DS, Carter BD, Kaelin WG Jr. The kinesin KIF1B{beta} acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev. 2008 Apr 1;22(7):884-93. Epub 2008 Mar 11. |
The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons
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Citation:
Neural Dev. 2013;[Email ahead of print] doi:10.1186/1749-8104-8-18 Epub:
Not Epub Abstract:
Background Circuit formation in the nervous system essentially relies on the proper development of neurons and their processes... Delivery Method:
Microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Schmeisser MJ, Kühl SJ, Schoen M, Beth NH, Weis TM, Grabrucker AM, Kühl M, Boeckers TM. The Nedd4-binding protein 3 (N4BP3) is crucial for axonal and dendritic branching in developing neurons. Neural Dev. 2013;[Email ahead of print] doi:10.1186/1749-8104-8-18. |
The Role of mbx in Zebrafish Brain Development
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Citation:
BUG Journal. 2003; Vol.6 (MIT) Epub:
Not Epub Abstract:
The dividing cells in an embryo need to specialize into particular types of cells as the embryo develops from a single cell... Delivery Method:
Microinjection Organism or Cell Type:
zebrafish Citation Extract: Scharf L. The Role of mbx in Zebrafish Brain Development. BUG Journal. 2003; Vol.6 (MIT). |
Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing
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Citation:
J Clin Invest. 2003 Aug;112(4):481-6 Epub:
Not Epub Abstract:
An estimated 60% of all human genes undergo alternative splicing, a highly regulated process that produces splice variants with... Citation Extract: Sazani P, Kole R. Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing. J Clin Invest. 2003 Aug;112(4):481-6. |
Ventx Factors Function as Nanog-Like Guardians of Developmental Potential in Xenopus
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Citation:
PLoS ONE. 2012;7(5): e36855. doi:10.1371/journal.pone.0036855 Epub:
Not Epub Abstract:
Vertebrate development requires progressive commitment of embryonic cells into specific lineages through a continuum of signals... Delivery Method:
Microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Scerbo P, Girardot F, Vivien C, Markov GV, Luxardi G, Demeneix B, Kodjabachian L, Coen L. Ventx Factors Function as Nanog-Like Guardians of Developmental Potential in Xenopus. PLoS ONE. 2012;7(5): e36855. doi:10.1371/journal.pone.0036855. |
Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning
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Citation:
Dev Biol. 2010 Sep 18. [Epub ahead of print] Epub:
Not Epub Abstract:
The establishment of the left-right (LR) axis in zebrafish embryos relies on signals from the dorsal forerunner cells (DFC) and... Organism or Cell Type:
zebrafish Citation Extract: Schneider I, Schneider PN, Derry SW, Lin S, Barton LJ, Westfall T, Slusarski DC. Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Dev Biol. 2010 Sep 18. [Epub ahead of print]. |
αE-catenin regulates cell-cell adhesion and membrane blebbing during zebrafish epiboly
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Citation:
Development. 2011 Dec 21. [Epub ahead of print] Epub:
Not Epub Abstract:
αE-catenin is an actin-binding protein associated with the E-cadherin-based adherens junction that regulates cell-cell adhesion... Delivery Method:
Microinjection Organism or Cell Type:
zebrafish Citation Extract: Schepis A, Sepich D, Nelson WJ. αE-catenin regulates cell-cell adhesion and membrane blebbing during zebrafish epiboly. Development. 2011 Dec 21. [Epub ahead of print]. |