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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12449 scientific papers returned from the database with the search filters currently being used below.

Systemic Injection of Peptide-PMOs into Humanized DMD Mice and Detection by RT-PCR and ELISA

Authors:
Melo D, Maruyama R, Yokota T
Citation:
Methods Mol Biol. 2025;2964:231-242. doi: 10.1007/978-1-0716-4730-1_15. PMID: 40720022
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder due to the lack of dystrophin production. The disease is...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4730-1_15
Delivery Method:
peptide-linked; mice: retro-orbital injection
Organism or Cell Type:
humanized DMD mice
Citation Extract:
Melo D, Maruyama R, Yokota T. Systemic Injection of Peptide-PMOs into Humanized DMD Mice and Detection by RT-PCR and ELISA. Methods Mol Biol. 2025;2964:231-242. doi: 10.1007/978-1-0716-4730-1_15. PMID: 40720022.

In Vivo Evaluation of Single- and Multi-Exon-Skipping in mdx52 Mice

Authors:
Sathyaprakash C, Takeuchi E, Takizawa H, Ashida Y, Tominari T, Echigoya Y, Yokota T, Aoki Y
Citation:
Methods Mol Biol. 2025;2964:243-261. doi: 10.1007/978-1-0716-4730-1_16. PMID: 40720023
Epub:
Not Epub
Abstract:
Exon-skipping therapy is an emerging approach that uses synthetic DNA-like molecules called antisense oligonucleotides (ASOs)...
Link:
https://link.springer.com/protocol/10.1007/978-1-0716-4730-1_16
Delivery Method:
intravenous (i.v.) injection
Organism or Cell Type:
mdx52 mice
Citation Extract:
Sathyaprakash C, Takeuchi E, Takizawa H, Ashida Y, Tominari T, Echigoya Y, Yokota T, Aoki Y. In Vivo Evaluation of Single- and Multi-Exon-Skipping in mdx52 Mice. Methods Mol Biol. 2025;2964:243-261. doi: 10.1007/978-1-0716-4730-1_16. PMID: 40720023.

Foxi1 regulates multiple steps of mucociliary development and ionocyte specification through transcriptional and epigenetic mechanisms

Authors:
Bowden S, Brislinger-Engelhardt MM, Hansen M, Temporal-Plo A, Weber D, Hägele S, Lorenz F, Litwin T, Kreutz C, Walentek P
Citation:
bioRxiv [Preprint]. 2024 Nov 4:2024.10.27.620464. doi: 10.1101/2024.10.27.620464. PMID: 39484493; PMCID: PMC11527170
Epub:
Not Epub
Abstract:
Foxi1 is a master regulator of ionocytes (ISCs / INCs) across species and organs. Two subtypes of ISCs exist, and both α- and β...
Link:
https://www.biorxiv.org/content/10.1101/2024.10.27.620464v3.full
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Bowden S, Brislinger-Engelhardt MM, Hansen M, Temporal-Plo A, Weber D, Hägele S, Lorenz F, Litwin T, Kreutz C, Walentek P. Foxi1 regulates multiple steps of mucociliary development and ionocyte specification through transcriptional and epigenetic mechanisms. bioRxiv [Preprint]. 2024 Nov 4:2024.10.27.620464. doi: 10.1101/2024.10.27.620464. PMID: 39484493; PMCID: PMC11527170.

ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis

Authors:
Chen W, Wu J, She P, Li J, Lan Y, Hu X, Huangfu Y, Wu C, Jin D, Xie P, Zhuang G, Wu Y, Zhang Y, Zon LI, Zhu P, Zhong TP
Citation:
Nat Commun. 2025 Jul 16;16(1):6550. doi: 10.1038/s41467-025-61680-7. PMID: 40670340; PMCID: PMC12267628
Epub:
Not Epub
Abstract:
T lymphocytes, which are essential for cell-mediated immunity in vertebrates, rely on thymic seeding of lymphoid progenitors...
Link:
https://www.nature.com/articles/s41467-025-61680-7
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen W, Wu J, She P, Li J, Lan Y, Hu X, Huangfu Y, Wu C, Jin D, Xie P, Zhuang G, Wu Y, Zhang Y, Zon LI, Zhu P, Zhong TP. ATF7IP/SETDB1-mediated epigenetic programming regulates thymic homing and T lymphopoiesis of hematopoietic progenitors during embryogenesis. Nat Commun. 2025 Jul 16;16(1):6550. doi: 10.1038/s41467-025-61680-7. PMID: 40670340; PMCID: PMC12267628.

ZSCAN4 functions as a safeguard to maintain centromere integrity during oocyte meiosis

Authors:
Choi DY, Leem J, Lee C, Oh JS
Citation:
Genome Biol. 2025 Jul 15;26(1):204. doi: 10.1186/s13059-025-03687-3. PMID: 40665375; PMCID: PMC12261598
Epub:
Not Epub
Abstract:
Background: Centromeres play a vital role in ensuring accurate chromosome segregation during meiosis by serving as the...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12261598/
Delivery Method:
microinjection
Organism or Cell Type:
CD1 mouse oocysts
Citation Extract:
Choi DY, Leem J, Lee C, Oh JS. ZSCAN4 functions as a safeguard to maintain centromere integrity during oocyte meiosis. Genome Biol. 2025 Jul 15;26(1):204. doi: 10.1186/s13059-025-03687-3. PMID: 40665375; PMCID: PMC12261598.

Transient versican expression is required for β1-Integrin accumulation during podocyte layer morphogenesis in amphibian developing kidney

Authors:
Buisson I, Riou JF, Umbhauer M, Le Bouffant R, Bello V
Citation:
bioRxiv [preprint] 2025.07.20.665792; doi: https://doi.org/10.1101/2025.07.20.665792
Epub:
Not Epub
Abstract:
The functional organization of the vertebrate nephron is remarkably conserved. However, the morphogenetic processes underlying...
Link:
https://www.biorxiv.org/content/10.1101/2025.07.20.665792v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Buisson I, Riou JF, Umbhauer M, Le Bouffant R, Bello V. Transient versican expression is required for β1-Integrin accumulation during podocyte layer morphogenesis in amphibian developing kidney. bioRxiv [preprint] 2025.07.20.665792; doi: https://doi.org/10.1101/2025.07.20.665792.

Using muscle homing peptide CyPep10 to deliver phosphorodiamidate morpholino oligomers in the mdx mouse

Authors:
Schneider A-FE, Tanganyika-de Winter CL, Jirka SMG, Tan X, Thompson EG, Ha K, Mitra A, Garcia S, Luimes M, Oliver RA, Guerlavais V, Aartsma-Rus A
Citation:
Molecular Therapy - Nucleic Acids (2025), doi: https://doi.org/10.1016/j.omtn.2025.102625
Epub:
Not Epub
Abstract:
The severe muscle wasting disorder Duchenne muscular dystrophy (DMD) is characterized by the absence of dystrophin, a protein...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(25)00179-9
Delivery Method:
CP10 and acetyl-R6Gly peptide-linked; intravenous (i.v.)
Organism or Cell Type:
mdx mice
Citation Extract:
Schneider A-FE, Tanganyika-de Winter CL, Jirka SMG, Tan X, Thompson EG, Ha K, Mitra A, Garcia S, Luimes M, Oliver RA, Guerlavais V, Aartsma-Rus A. Using muscle homing peptide CyPep10 to deliver phosphorodiamidate morpholino oligomers in the mdx mouse. Molecular Therapy - Nucleic Acids (2025), doi: https://doi.org/10.1016/j.omtn.2025.102625.

Prdx6 regulates in vivo myeloid cell development via redox control during Xenopus embryogenesis

Authors:
Kim M, Lee HK, Lee H, Lee HS
Citation:
Anim Cells Syst (Seoul). 2025 Jul 16;29(1):438-445. doi: 10.1080/19768354.2025.2533823. PMID: 40677760; PMCID: PMC12269089
Epub:
Not Epub
Abstract:
Peroxiredoxin6 (Prdx6) is a bifunctional antioxidant enzyme with both peroxidase and phospholipase A₂ activities. Although its...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12269089/
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim M, Lee HK, Lee H, Lee HS. Prdx6 regulates in vivo myeloid cell development via redox control during Xenopus embryogenesis. Anim Cells Syst (Seoul). 2025 Jul 16;29(1):438-445. doi: 10.1080/19768354.2025.2533823. PMID: 40677760; PMCID: PMC12269089.

Perfluorodecanesulfonate (PFDS) induces innate immune toxicity through the NF-κB pathway in early life stage zebrafish

Authors:
Zhou C, Chen W, Xuan R, Kang X, Wang J, Magnuson JT, Li J, Fang D, Qiu W
Citation:
Environ Int. 2025 Jul 16;202:109688. doi: 10.1016/j.envint.2025.109688. Epub ahead of print. PMID: 40683240
Epub:
Not Epub
Abstract:
Perfluorodecanesulfonate (PFDS), a long-chain polyfluoroalkyl substance (PFAS), is widely detected in aquatic environments and...
Link:
https://www.sciencedirect.com/science/article/pii/S0160412025004398
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhou C, Chen W, Xuan R, Kang X, Wang J, Magnuson JT, Li J, Fang D, Qiu W. Perfluorodecanesulfonate (PFDS) induces innate immune toxicity through the NF-κB pathway in early life stage zebrafish. Environ Int. 2025 Jul 16;202:109688. doi: 10.1016/j.envint.2025.109688. Epub ahead of print. PMID: 40683240.

Insights into the evolution and regulation of hybrid internal-terminal exons from tropomyosin exon 9A in Xenopus laevis

Authors:
Méreau A, Lerivray H, Viet J, Hardy S, Paillard L, Audic Y
Citation:
Biochimie. 2025 Jul 9:S0300-9084(25)00150-6. doi: 10.1016/j.biochi.2025.07.009. Epub ahead of print. PMID: 40645271
Epub:
Not Epub
Abstract:
Hybrid internal-terminal exons function as either internal or terminal exons. Their evolutionary origins remain unclear. Here,...
Link:
https://www.sciencedirect.com/science/article/pii/S0300908425001506
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Méreau A, Lerivray H, Viet J, Hardy S, Paillard L, Audic Y. Insights into the evolution and regulation of hybrid internal-terminal exons from tropomyosin exon 9A in Xenopus laevis. Biochimie. 2025 Jul 9:S0300-9084(25)00150-6. doi: 10.1016/j.biochi.2025.07.009. Epub ahead of print. PMID: 40645271.

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