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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12428 scientific papers returned from the database with the search filters currently being used below.

Remodeling of cadherin contacts in embryonic mesenchymal tissues during differential cell migration

Authors:
Rozema D, Fagotto-Kaufmann C, Ruppel A, Lasko P, Fagotto F
Citation:
Dev Cell. 2025 Jul 3:S1534-5807(25)00364-8. doi: 10.1016/j.devcel.2025.06.009. Epub ahead of print. PMID: 40614715
Epub:
Not Epub
Abstract:
A fundamental aspect of morphogenesis is the capacity of cells to actively exchange neighbors, which crucially requires...
Link:
https://www.cell.com/developmental-cell/abstract/S1534-5807(25)00364-8
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Rozema D, Fagotto-Kaufmann C, Ruppel A, Lasko P, Fagotto F. Remodeling of cadherin contacts in embryonic mesenchymal tissues during differential cell migration. Dev Cell. 2025 Jul 3:S1534-5807(25)00364-8. doi: 10.1016/j.devcel.2025.06.009. Epub ahead of print. PMID: 40614715.

A multi-tiered mechanical mechanism shapes the early neural plate

Authors:
Inman A, Spiritosanto E, Evans BL, Lutton JE, Tada M, Bretschneider T, Haas PA, Smutny M
Citation:
Nat Commun. 2025 Jul 4;16(1):6187. doi: 10.1038/s41467-025-61303-1. PMID: 40615398; PMCID: PMC12227548
Epub:
Not Epub
Abstract:
The formation of complex tissues during embryonic development requires an intricate spatiotemporal coordination of local...
Link:
https://www.nature.com/articles/s41467-025-61303-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Inman A, Spiritosanto E, Evans BL, Lutton JE, Tada M, Bretschneider T, Haas PA, Smutny M. A multi-tiered mechanical mechanism shapes the early neural plate. Nat Commun. 2025 Jul 4;16(1):6187. doi: 10.1038/s41467-025-61303-1. PMID: 40615398; PMCID: PMC12227548.

Progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis

Authors:
Rajan SG, Nacke LM, Lombardo JN, Manuchehrfar F, Wong K, Kanabar P, Somodji EA, Garcia J, Maienschein-Cline M, Liang J, Saxena A
Citation:
Stem Cell Reports. 2025 Jun 26:102575. doi: 10.1016/j.stemcr.2025.102575. Epub ahead of print. PMID: 40614732
Epub:
Not Epub
Abstract:
Olfactory neurogenesis occurs throughout the lives of vertebrates, including in humans, and relies on the continuous...
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(23)00176-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Rajan SG, Nacke LM, Lombardo JN, Manuchehrfar F, Wong K, Kanabar P, Somodji EA, Garcia J, Maienschein-Cline M, Liang J, Saxena A. Progenitor neighborhoods function as transient niches to sustain olfactory neurogenesis. Stem Cell Reports. 2025 Jun 26:102575. doi: 10.1016/j.stemcr.2025.102575. Epub ahead of print. PMID: 40614732.

Exon skipping peptide-conjugated morpholinos downregulate dynamin 2 to rescue centronuclear myopathy

Authors:
Moschovaki-Filippidou F, de Carvalho Neves J, Diedhiou N, Jad Y, Böhm J, Wood MJA, Varela MA, Laporte J
Citation:
Brain. 2025 Jul 3:awaf249. doi: 10.1093/brain/awaf249. Epub ahead of print. PMID: 40608957
Epub:
Not Epub
Abstract:
Centronuclear myopathies (CNM) are rare congenital disorders characterized by muscle weakness and disorganization of myofibers...
Link:
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awaf249/8185529
Delivery Method:
Pip8b2 peptide-linked; mice: intravenous (i.v.) and intramuscular (i.m.) in the tibialis anterior (TA)
Organism or Cell Type:
cell culture: C2C12 mouse myoblasts; mice: Dnm2R369W/+
Citation Extract:
Moschovaki-Filippidou F, de Carvalho Neves J, Diedhiou N, Jad Y, Böhm J, Wood MJA, Varela MA, Laporte J. Exon skipping peptide-conjugated morpholinos downregulate dynamin 2 to rescue centronuclear myopathy. Brain. 2025 Jul 3:awaf249. doi: 10.1093/brain/awaf249. Epub ahead of print. PMID: 40608957.

Vps34 knockdown attenuated AlNPs-induced neurodevelopmental toxicity in zebrafish larvae and adults by inhibiting mitophagy

Authors:
Zhang Y, Zhao J, Huang T, Gao X, Zhang L, Wang Y, Guo X, Zhang L, Niu Q, Zhang Q
Citation:
Aquat Toxicol. 2025 Jul 1;286:107479. doi: 10.1016/j.aquatox.2025.107479. Epub ahead of print. PMID: 40616935
Epub:
Not Epub
Abstract:
Nano-alumina (AlNPs) are susceptible to inducing neurotoxicity, mainly through excessive autophagy/mitophagy. Vacuolar protein...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S0166445X25002437
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhang Y, Zhao J, Huang T, Gao X, Zhang L, Wang Y, Guo X, Zhang L, Niu Q, Zhang Q. Vps34 knockdown attenuated AlNPs-induced neurodevelopmental toxicity in zebrafish larvae and adults by inhibiting mitophagy. Aquat Toxicol. 2025 Jul 1;286:107479. doi: 10.1016/j.aquatox.2025.107479. Epub ahead of print. PMID: 40616935.

Variants in NR6A1 cause a novel oculo-vertebral-renal (OVR) syndrome

Authors:
Neelathi UM, Ullah E, George A, Maftei MI, Boobalan E, Sanchez-Mendoza D, Adams C, McGaughey D, Sergeev YV, Rawi RA, Naik A, Bender C, Maumenee IH, Michaelides M, Tan TG, Lin S, Villasmil R, Blain D, Hufnagel RB, Arno G, Young RM, Guan B, Brooks BP
Citation:
Res Sq [Preprint]. 2024 Nov 15:rs.3.rs-5375105. doi: 10.21203/rs.3.rs-5375105/v1. PMID: 39606449; PMCID: PMC11601836
Epub:
Not Epub
Abstract:
Colobomatous microphthalmia is a potentially blinding congenital ocular malformation that can present either in isolation or...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11601836/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Neelathi UM, Ullah E, George A, Maftei MI, Boobalan E, Sanchez-Mendoza D, Adams C, McGaughey D, Sergeev YV, Rawi RA, Naik A, Bender C, Maumenee IH, Michaelides M, Tan TG, Lin S, Villasmil R, Blain D, Hufnagel RB, Arno G, Young RM, Guan B, Brooks BP. Variants in NR6A1 cause a novel oculo-vertebral-renal (OVR) syndrome. Res Sq [Preprint]. 2024 Nov 15:rs.3.rs-5375105. doi: 10.21203/rs.3.rs-5375105/v1. PMID: 39606449; PMCID: PMC11601836.

Itpka depletion implicates defects in anterior neural development of Xenopus laevis

Authors:
Saumweber EG, Becker MC, Kunkel S, Welke J, Schott S, Vizinho-Vieira C, Faoual S, Schmeisser MJ, Kühl SJ
Citation:
Front. Cell Dev. Biol.Sec. Embryonic Development. Volume 13 - 2025
Epub:
Not Epub
Abstract:
Inositol 1,4,5-trisphosphate 3-kinase A (Itpka) is a neuronal isoform of the ITPK family that regulates both actin dynamics and...
Link:
https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2025.1610183/abstract
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Saumweber EG, Becker MC, Kunkel S, Welke J, Schott S, Vizinho-Vieira C, Faoual S, Schmeisser MJ, Kühl SJ. Itpka depletion implicates defects in anterior neural development of Xenopus laevis. Front. Cell Dev. Biol.Sec. Embryonic Development. Volume 13 - 2025.

Maternal thyroid hormone is required to develop the hindbrain vasculature in zebrafish

Authors:
Trindade M, Silva N, Rodrigues J, Kawakami K, Campinho MA
Citation:
Commun Biol. 2025 Jul 1;8(1):960. doi: 10.1038/s42003-025-08404-1. PMID: 40593336; PMCID: PMC12216513
Epub:
Not Epub
Abstract:
Thyroid hormone (TH) signaling is important and necessary for proper neurodevelopment. Inadequate levels of maternally derived...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12216513/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Trindade M, Silva N, Rodrigues J, Kawakami K, Campinho MA. Maternal thyroid hormone is required to develop the hindbrain vasculature in zebrafish. Commun Biol. 2025 Jul 1;8(1):960. doi: 10.1038/s42003-025-08404-1. PMID: 40593336; PMCID: PMC12216513.

Disrupted macrophage metabolic adaptation and function drive senescence-induced decline in vertebrate regeneration

Authors:
Barthelaix A, Terraza-Aguirre C, Del Río-Jay Y, Bohaud C, Salvador J, Morille M, Ferreira MG, Jorgensen C, Djouad F
Citation:
Theranostics. 2025; 15(15): 7308-7326
Epub:
Not Epub
Abstract:
Rationale: Senescent cells accumulate with age and contribute to impaired tissue regeneration. Here, we developed a...
Link:
https://www.thno.org/v15p7308.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Barthelaix A, Terraza-Aguirre C, Del Río-Jay Y, Bohaud C, Salvador J, Morille M, Ferreira MG, Jorgensen C, Djouad F. Disrupted macrophage metabolic adaptation and function drive senescence-induced decline in vertebrate regeneration. Theranostics. 2025; 15(15): 7308-7326.

A genetic modifier links integrin α5 to the phenotypic variation in fibronectin 1a mutant zebrafish

Authors:
Capon SJ, Maroufidou A, Feltes M, Xu Y, Matharoo DK, Jülich D, Holley SA, Farber SA, Stainier DYR
Citation:
PLoS Genet. 2025 Jun 23;21(6):e1011747. doi: 10.1371/journal.pgen.1011747. PMID: 40549824; PMCID: PMC12212883
Epub:
Not Epub
Abstract:
Phenotypic variation is often observed in individuals with the same mutation. However, the mechanisms that contribute to this...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12212883/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Capon SJ, Maroufidou A, Feltes M, Xu Y, Matharoo DK, Jülich D, Holley SA, Farber SA, Stainier DYR. A genetic modifier links integrin α5 to the phenotypic variation in fibronectin 1a mutant zebrafish. PLoS Genet. 2025 Jun 23;21(6):e1011747. doi: 10.1371/journal.pgen.1011747. PMID: 40549824; PMCID: PMC12212883.

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