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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12378 scientific papers returned from the database with the search filters currently being used below.

SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function

Authors:
Ranjan G, Sehgal P, Scaria V, Sivasubbu S
Citation:
bioRxiv [preprint] 2024.07.21.604148; doi: https://doi.org/10.1101/2024.07.21.604148
Epub:
Not Epub
Abstract:
Syntenic conservation is an effective strategy to identify evolutionarily conserved lncRNA orthologs. In this study, we...
Link:
https://www.biorxiv.org/content/10.1101/2024.07.21.604148v1.full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ranjan G, Sehgal P, Scaria V, Sivasubbu S. SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function. bioRxiv [preprint] 2024.07.21.604148; doi: https://doi.org/10.1101/2024.07.21.604148.

Sall4 regulates downstream patterning genes during limb regeneration

Authors:
Erickson JR, Walker SE, Arenas Gomez C, Echeverri K
Citation:
Dev Biol. 2024 Jul 25:S0012-1606(24)00195-7. doi: 10.1016/j.ydbio.2024.07.015. Epub ahead of print. PMID: 39067503.
Epub:
Not Epub
Abstract:
Many salamanders can completely regenerate a fully functional limb. Limb regeneration is a carefully coordinated process...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160624001957
Delivery Method:
injection then electroporation
Organism or Cell Type:
Ambystoma mexicanum (Axolotl)
Citation Extract:
Erickson JR, Walker SE, Arenas Gomez C, Echeverri K. Sall4 regulates downstream patterning genes during limb regeneration. Dev Biol. 2024 Jul 25:S0012-1606(24)00195-7. doi: 10.1016/j.ydbio.2024.07.015. Epub ahead of print. PMID: 39067503..

Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin- and empagliflozin-induced arterial relaxation

Authors:
Forrester EA, Benítez-Angeles M, Redford KE, Rosenbaum T, Abbott GW, Barrese V, Dora K, Albert AP, Dannesboe J, Salles-Crawley I, Jepps TA, Greenwood IA
Citation:
Cardiovasc Res. 2024 Nov 25;120(14):1811-1824. doi: 10.1093/cvr/cvae156. PMID: 39056245; PMCID: PMC11587556
Epub:
Not Epub
Abstract:
Aims: Sodium/glucose transporter 2 (SGLT2 or SLC5A2) inhibitors lower blood glucose and are also approved treatments for heart...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11587556/
Delivery Method:
Lipofectamine 2000
Organism or Cell Type:
NHE1 knockout mouse explant: mesenteric arteries
Citation Extract:
Forrester EA, Benítez-Angeles M, Redford KE, Rosenbaum T, Abbott GW, Barrese V, Dora K, Albert AP, Dannesboe J, Salles-Crawley I, Jepps TA, Greenwood IA . Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin- and empagliflozin-induced arterial relaxation. Cardiovasc Res. 2024 Nov 25;120(14):1811-1824. doi: 10.1093/cvr/cvae156. PMID: 39056245; PMCID: PMC11587556.

CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression

Authors:
Baker CE, Marta AG, Zimmerman ND, Korade Z, Mathy NW, Wilton D, Simeone T, Kochvar A, Kramer KL, Stessman HAF, Shibata A
Citation:
Biomolecules. 2024; 14(8):914
Epub:
Not Epub
Abstract:
Carnitine palmitoyltransferase 2 (CPT2) is an inner mitochondrial membrane protein of the carnitine shuttle and is involved in...
Link:
https://www.mdpi.com/2218-273X/14/8/914
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Baker CE, Marta AG, Zimmerman ND, Korade Z, Mathy NW, Wilton D, Simeone T, Kochvar A, Kramer KL, Stessman HAF, Shibata A. CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression. Biomolecules. 2024; 14(8):914.

Mycb and Mych stimulate Müller glial cell reprogramming and proliferation in the uninjured and injured zebrafish retina

Authors:
Lee MS, Jui J, Sahu A, Goldman D
Citation:
Development. 2024 Jul 10:dev.203062. doi: 10.1242/dev.203062. Epub ahead of print. PMID: 38984586
Epub:
Not Epub
Abstract:
In the injured zebrafish retina, Müller glial cells (MG) reprogram to adopt retinal stem cell properties and regenerate damaged...
Link:
https://journals.biologists.com/dev/article/doi/10.1242/dev.203062/359756/Mycb-and-Mych-stimulate-Muller-glial-cell
Delivery Method:
intravitreal injection and electroporation
Organism or Cell Type:
zebrafish
Citation Extract:
Lee MS, Jui J, Sahu A, Goldman D. Mycb and Mych stimulate Müller glial cell reprogramming and proliferation in the uninjured and injured zebrafish retina. Development. 2024 Jul 10:dev.203062. doi: 10.1242/dev.203062. Epub ahead of print. PMID: 38984586.

Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation

Authors:
Chen S, Yin J, Liang J, Zhang W, Jiang P, Wang W, Chen X, Zhou Y, Xia P, Yang F, Gu Y, Zhang R, Han P
Citation:
bioRxiv 2024.05.09.593293; doi: https://doi.org/10.1101/2024.05.09.593293
Epub:
Not Epub
Abstract:
Biomechanical cues play an essential role in sculpting organ formation. Comprehending how cardiac cells perceive and respond to...
Link:
https://www.biorxiv.org/content/10.1101/2024.05.09.593293v1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen S, Yin J, Liang J, Zhang W, Jiang P, Wang W, Chen X, Zhou Y, Xia P, Yang F, Gu Y, Zhang R, Han P. Contraction-induced endocardial id2b plays a dual role in regulating myocardial contractility and valve formation. bioRxiv 2024.05.09.593293; doi: https://doi.org/10.1101/2024.05.09.593293.

Mechanical forces remodel the cardiac extracellular matrix during zebrafish development

Authors:
Gentile A, Albu M, Xu Y, Mortazavi N, Ribeiro da Silva A, Stainier DYR, Gunawan F
Citation:
Development. 2024 Jul 1;151(13):dev202310. doi: 10.1242/dev.202310. Epub 2024 Jul 10. PMID: 38984541
Epub:
Not Epub
Abstract:
The cardiac extracellular matrix (cECM) is fundamental for organ morphogenesis and maturation, during which time it undergoes...
Link:
https://journals.biologists.com/dev/article/151/13/dev202310/359785/Mechanical-forces-remodel-the-cardiac
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Gentile A, Albu M, Xu Y, Mortazavi N, Ribeiro da Silva A, Stainier DYR, Gunawan F. Mechanical forces remodel the cardiac extracellular matrix during zebrafish development. Development. 2024 Jul 1;151(13):dev202310. doi: 10.1242/dev.202310. Epub 2024 Jul 10. PMID: 38984541.

Elp1 function in placode-derived neurons is critical for proper trigeminal ganglion development

Authors:
Hines MA, Taneyhill LA
Citation:
Dev Dyn. 2024 Oct 9. doi: 10.1002/dvdy.749. Epub ahead of print. PMID: 39381860
Epub:
Not Epub
Abstract:
Background The trigeminal nerve is the largest cranial nerve and functions in somatosensation. Cell bodies of this nerve are...
Link:
https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.749
Delivery Method:
electroporation
Organism or Cell Type:
chick trigeminal placode cells
Citation Extract:
Hines MA, Taneyhill LA. Elp1 function in placode-derived neurons is critical for proper trigeminal ganglion development. Dev Dyn. 2024 Oct 9. doi: 10.1002/dvdy.749. Epub ahead of print. PMID: 39381860.

A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing

Authors:
Saulnier O, Zagozewski J, Liang L, Hendrikse LD, Layug P, Gordon V, Aldinger KA, Haldipur P, Borlase S, Coudière-Morrison L, Cai T, Martell E, Gonzales NM, Palidwor G, Porter CJ, Richard S, Sharif T, Millen KJ, Doble BW, Taylor MD, Werbowetski-Ogilvie TE
Citation:
Nat Cell Biol. 2024 Jul 18. doi: 10.1038/s41556-024-01460-5. Epub ahead of print. PMID: 39025928.
Epub:
Not Epub
Abstract:
OTX2 is a transcription factor and known driver in medulloblastoma (MB), where it is amplified in a subset of tumours and...
Link:
https://www.nature.com/articles/s41556-024-01460-5
Delivery Method:
Pre-treat cells then cerebellum injection into NOD-SCID mice
Organism or Cell Type:
HDMB03 and MB3W1 cell line-derived tumourspheres
Citation Extract:
Saulnier O, Zagozewski J, Liang L, Hendrikse LD, Layug P, Gordon V, Aldinger KA, Haldipur P, Borlase S, Coudière-Morrison L, Cai T, Martell E, Gonzales NM, Palidwor G, Porter CJ, Richard S, Sharif T, Millen KJ, Doble BW, Taylor MD, Werbowetski-Ogilvie TE. A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing. Nat Cell Biol. 2024 Jul 18. doi: 10.1038/s41556-024-01460-5. Epub ahead of print. PMID: 39025928..

The Usefulness of Determining Plasma and Tissue Concentrations of Phosphorodiamidate Morpholino Oligonucleotides to Estimate Their Efficacy in Duchenne Muscular Dystrophy Patients

Authors:
Imai S, Watanabe N, Tone Y, Mitamura R, Mori J, Kameyama T, Yamada T, Kusano K
Citation:
Drug Metab Dispos. 2024 Aug 14;52(9):1029-1036. doi: 10.1124/dmd.124.001806. PMID: 38991781
Epub:
Not Epub
Abstract:
Currently four kinds of phosphorodiamidate morpholino oligomers (PMOs) such as viltolarsen have been approved for the treatment...
Link:
https://dmd.aspetjournals.org/content/52/9/1029.long
Delivery Method:
i.v. bolus injection (mice), i.v. infusion and bolus injection (monkey)
Organism or Cell Type:
mice (mdx): C57BL/10ScSn-DmdmdxJ, Cynomolgus monkeys
Citation Extract:
Imai S, Watanabe N, Tone Y, Mitamura R, Mori J, Kameyama T, Yamada T, Kusano K. The Usefulness of Determining Plasma and Tissue Concentrations of Phosphorodiamidate Morpholino Oligonucleotides to Estimate Their Efficacy in Duchenne Muscular Dystrophy Patients. Drug Metab Dispos. 2024 Aug 14;52(9):1029-1036. doi: 10.1124/dmd.124.001806. PMID: 38991781.

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