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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12165 scientific papers returned from the database with the search filters currently being used below.

MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3′UTR and predicts poor survival in non-small cell lung cancer

Authors:
Duan F-G, Wang M-F, Cao Y-B, Li D, Li R-Z, Fan X-X, Khan I, Lai H-L, Zhang Y-Z, Hsiao WW-L, Yao X-J, Wu Q-B, Liu L, Tang I-J, Leung EL-H
Citation:
Cell Death Dis. 2019;10:821. doi:10.1038/s41419-019-2031-1
Epub:
Not Epub
Abstract:
MicroRNAs regulate post-transcriptional gene expression and play important roles in multiple cellular processes. In this study...
Delivery Method:
intratumoral injection
Organism or Cell Type:
cell culture: human NSCLC A549; mouse xenograft
Citation Extract:
Duan F-G, Wang M-F, Cao Y-B, Li D, Li R-Z, Fan X-X, Khan I, Lai H-L, Zhang Y-Z, Hsiao WW-L, Yao X-J, Wu Q-B, Liu L, Tang I-J, Leung EL-H. MicroRNA-421 confers paclitaxel resistance by binding to the KEAP1 3′UTR and predicts poor survival in non-small cell lung cancer. Cell Death Dis. 2019;10:821. doi:10.1038/s41419-019-2031-1.

Generation of MuRF-GFP transgenic zebrafish models for investigating murf gene expression and protein localization in Smyd1b and Hsp90α1 knockdown embryos

Authors:
Li B, Li S, He Q, Du S
Citation:
Comp Biochem Physiol B. 2019;[Epub ahead of print] doi:10.1016/j.cbpb.2019.110368
Epub:
Yes
Abstract:
Muscle-specific RING-finger proteins (MuRFs) are E3 ubiquitin ligases that play important roles in protein quality control in...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li B, Li S, He Q, Du S. Generation of MuRF-GFP transgenic zebrafish models for investigating murf gene expression and protein localization in Smyd1b and Hsp90α1 knockdown embryos. Comp Biochem Physiol B. 2019;[Epub ahead of print] doi:10.1016/j.cbpb.2019.110368.

POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4

Authors:
Sanchez E, Laplace-Builhé B, Mau-Them FT, Richard E, Goldenberg A, Toler TL, Guignard T, Gatinois V, Vincent M, Blanchet C, Boland A, Bihoreau MT, Deleuze JF, Olaso R, Nephi W, Lüdecke HJ, Verheij JBGM, Moreau-Lenoir F, Denoyelle F, Rivière JB, Laplanche JL, Willing M, Captier G, Apparailly F, Wieczorek D, Collet C, Djouad F, Geneviève D
Citation:
Genet Med. 2019 Oct 24. doi: 10.1038/s41436-019-0669-9. [Epub ahead of print]
Epub:
Yes
Abstract:
PURPOSE: Treacher Collins syndrome (TCS) is a rare autosomal dominant mandibulofacial dysostosis, with a prevalence of 0.2-1/10...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Sanchez E, Laplace-Builhé B, Mau-Them FT, Richard E, Goldenberg A, Toler TL, Guignard T, Gatinois V, Vincent M, Blanchet C, Boland A, Bihoreau MT, Deleuze JF, Olaso R, Nephi W, Lüdecke HJ, Verheij JBGM, Moreau-Lenoir F, Denoyelle F, Rivière JB, Laplanche JL, Willing M, Captier G, Apparailly F, Wieczorek D, Collet C, Djouad F, Geneviève D. POLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4. Genet Med. 2019 Oct 24. doi: 10.1038/s41436-019-0669-9. [Epub ahead of print].

Interleukin-6 signaling regulates hematopoietic stem cell emergence

Authors:
Tie R, Li H, Cai S, Liang Z, Shan W, Wang B, Tan Y, Zheng W, Huang H
Citation:
Exp Mol Med. 2019 Oct 24;51(10):124. doi: 10.1038/s12276-019-0320-5
Epub:
Not Epub
Abstract:
Hematopoietic stem cells (HSCs) produce all lineages of mature blood cells for the lifetime of an organism. In vertebrates,...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Tie R, Li H, Cai S, Liang Z, Shan W, Wang B, Tan Y, Zheng W, Huang H. Interleukin-6 signaling regulates hematopoietic stem cell emergence. Exp Mol Med. 2019 Oct 24;51(10):124. doi: 10.1038/s12276-019-0320-5.

Loss-of-spen disturbs cardiac conduction in zebrafish mediated by impaired connexin43 function

Authors:
Rattka M, Westphal S, Pott A, Kessler M, Weinmann K, Just S, Rottbauer W
Citation:
Eur Heart J, 2019;40(Supplement_1):ehz746.0023. doi:10.1093/eurheartj/ehz746.0023
Epub:
Not Epub
Abstract:
Genome-wide association studies identified SPLIT ENDS (SPEN) gene as an interesting candidate in the pathogenesis of heart...
Organism or Cell Type:
zebrafish
Citation Extract:
Rattka M, Westphal S, Pott A, Kessler M, Weinmann K, Just S, Rottbauer W. Loss-of-spen disturbs cardiac conduction in zebrafish mediated by impaired connexin43 function. Eur Heart J, 2019;40(Supplement_1):ehz746.0023. doi:10.1093/eurheartj/ehz746.0023.

Bioinformatics Screening of Genes Specific for Well-Regenerating Vertebrates Reveals c-answer, a Regulator of Brain Development and Regeneration

Authors:
Korotkova DD, Lyubetsky VA, Ivanova AS, Rubanov LI, Seliverstov AV, Zverkov OA, Martynova NY, Nesterenko AM, Tereshina MB, Peshkin L, Zaraisky AG
Citation:
Cell Rep. 2019 Oct 22;29(4):1027-1040.e6. doi: 10.1016/j.celrep.2019.09.038
Epub:
Not Epub
Abstract:
The molecular basis of higher regenerative capacity of cold-blooded animals comparing to warm-blooded ones is poorly understood...
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Korotkova DD, Lyubetsky VA, Ivanova AS, Rubanov LI, Seliverstov AV, Zverkov OA, Martynova NY, Nesterenko AM, Tereshina MB, Peshkin L, Zaraisky AG. Bioinformatics Screening of Genes Specific for Well-Regenerating Vertebrates Reveals c-answer, a Regulator of Brain Development and Regeneration. Cell Rep. 2019 Oct 22;29(4):1027-1040.e6. doi: 10.1016/j.celrep.2019.09.038.

Differential Expression of a Classic Cadherin Directs Tissue-Level Contractile Asymmetry during Neural Tube Closure

Authors:
Hashimoto H, Munro E
Citation:
Dev Cell. 2019 Oct 21;51(2):158-172.e4. doi: 10.1016/j.devcel.2019.10.001
Epub:
Not Epub
Abstract:
Embryos control force generation at tissue bound-aries, but how they do so remains poorly understood.Here we show how tissue-...
Delivery Method:
microinjection
Organism or Cell Type:
Ciona robusta (AKA C. intestinalis; ascidian)
Citation Extract:
Hashimoto H, Munro E. Differential Expression of a Classic Cadherin Directs Tissue-Level Contractile Asymmetry during Neural Tube Closure. Dev Cell. 2019 Oct 21;51(2):158-172.e4. doi: 10.1016/j.devcel.2019.10.001.

Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia

Authors:
Wagner M, Osborn DPS, Gehweiler I, Nagel M, Ulmer U, Bakhtiari S, Amouri R, Boostani R, Hentati F, Hockley MM, Hölbling B, Schwarzmayr T, Karimiani EG, Kernstock C, Maroofian R, Müller-Felber W, Ozkan E, Padilla-Lopez S, Reich S, Reichbauer J, Darvish H, Shahmohammadibeni N, Tafakhori A, Vill K, Zuchner S, Kruer MC, Winkelmann J, Jamshidi Y, Schüle R
Citation:
Nat Commun. 2019 Oct 21;10(1):4790. doi: 10.1038/s41467-019-12620-9
Epub:
Not Epub
Abstract:
Alterations of Ca2+ homeostasis have been implicated in a wide range of neurodegenerative diseases. Ca2+ efflux from the...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wagner M, Osborn DPS, Gehweiler I, Nagel M, Ulmer U, Bakhtiari S, Amouri R, Boostani R, Hentati F, Hockley MM, Hölbling B, Schwarzmayr T, Karimiani EG, Kernstock C, Maroofian R, Müller-Felber W, Ozkan E, Padilla-Lopez S, Reich S, Reichbauer J, Darvish H, Shahmohammadibeni N, Tafakhori A, Vill K, Zuchner S, Kruer MC, Winkelmann J, Jamshidi Y, Schüle R. Bi-allelic variants in RNF170 are associated with hereditary spastic paraplegia. Nat Commun. 2019 Oct 21;10(1):4790. doi: 10.1038/s41467-019-12620-9.

The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis

Authors:
Cuenca A, Insinna C, Zhao H, John P, Weiss MA, Lu Q, Walia V, Specht S, Manivannan S, Stauffer J, Peden AA, Westlake CJ
Citation:
J Biol Chem. 2019 Oct 18;294(42):15418-15434. doi: 10.1074/jbc.RA119.008615. Epub 2019 Aug 29
Epub:
Not Epub
Abstract:
The primary cilium is a cellular sensor that detects light, chemicals, and movement and is important for morphogen and growth...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Cuenca A, Insinna C, Zhao H, John P, Weiss MA, Lu Q, Walia V, Specht S, Manivannan S, Stauffer J, Peden AA, Westlake CJ. The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis. J Biol Chem. 2019 Oct 18;294(42):15418-15434. doi: 10.1074/jbc.RA119.008615. Epub 2019 Aug 29.

Brain aromatase modulates cardiac functions in embryonic zebrafish

Authors:
Ulhaq ZS
Citation:
Int J Vet Sci Med. 2019;7(1):31-4. doi:10.1080/23144599.2019.1675287
Epub:
Not Epub
Abstract:
Oestradiol (E2) is known as a female reproductive hormone with pleiotropic effects on the cardiovascular system. Local E2...
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ulhaq ZS. Brain aromatase modulates cardiac functions in embryonic zebrafish. Int J Vet Sci Med. 2019;7(1):31-4. doi:10.1080/23144599.2019.1675287.

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