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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12152 scientific papers returned from the database with the search filters currently being used below.

Multi-omics integration analysis identifies pathogenic candidate genes of congenital heart defects with vascular malformation

Authors:
Ding XW, Huang JX, Chen YH, Li ZY, Wu YZ, Qian ZL, Feng WQ, Li YR, Zhao LD, Zhao PJ, Lu YN, Yu Y
Citation:
European Heart Journal, Volume 45, Issue Supplement_1, October 2024, ehae666.2109, https://doi.org/10.1093/eurheartj/ehae666.2109
Epub:
Not Epub
Abstract:
Background Congenital heart defects (CHD) with vascular malformation harbors numerous genetic and epigenetic aberrations of...
Link:
https://academic.oup.com/eurheartj/article/45/Supplement_1/ehae666.2109/7836991
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Ding XW, Huang JX, Chen YH, Li ZY, Wu YZ, Qian ZL, Feng WQ, Li YR, Zhao LD, Zhao PJ, Lu YN, Yu Y. Multi-omics integration analysis identifies pathogenic candidate genes of congenital heart defects with vascular malformation. European Heart Journal, Volume 45, Issue Supplement_1, October 2024, ehae666.2109, https://doi.org/10.1093/eurheartj/ehae666.2109.

Actin Depolymerizing Factor Destrin Regulates Cilia Development and Function during Vertebrate Embryogenesis

Authors:
Kim Y, Lee HK, Park KY, Ismail T, Lee H, Lee HS
Citation:
Dev Reprod. 2024 Sep;28(3):109-119. doi: 10.12717/DR.2024.28.3.109. Epub 2024 Sep 30. PMID: 39444639; PMCID: PMC11495882
Epub:
Not Epub
Abstract:
The actin cytoskeleton plays fundamental roles in ciliogenesis and the actin depolymerizing factor destrin regulates actin...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11495882/
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Kim Y, Lee HK, Park KY, Ismail T, Lee H, Lee HS. Actin Depolymerizing Factor Destrin Regulates Cilia Development and Function during Vertebrate Embryogenesis. Dev Reprod. 2024 Sep;28(3):109-119. doi: 10.12717/DR.2024.28.3.109. Epub 2024 Sep 30. PMID: 39444639; PMCID: PMC11495882.

Light-modulated neural control of sphincter regulation in the evolution of through-gut

Authors:
Yaguchi J, Sakai K, Horiuchi A, Yamamoto T, Yamashita T, Yaguchi S
Citation:
Nat Commun. 2024 Oct 18;15(1):8881. doi: 10.1038/s41467-024-53203-7. PMID: 39424783; PMCID: PMC11489725
Epub:
Not Epub
Abstract:
The development of a continuous digestive tract, or through-gut, represents a key milestone in bilaterian evolution. However,...
Link:
https://www.nature.com/articles/s41467-024-53203-7
Delivery Method:
microinjection
Organism or Cell Type:
Hemicentrotus pulcherrimus (sea urchin)
Citation Extract:
Yaguchi J, Sakai K, Horiuchi A, Yamamoto T, Yamashita T, Yaguchi S. Light-modulated neural control of sphincter regulation in the evolution of through-gut. Nat Commun. 2024 Oct 18;15(1):8881. doi: 10.1038/s41467-024-53203-7. PMID: 39424783; PMCID: PMC11489725.

Emx2 is an essential regulator of ciliated cell development across embryonic tissues

Authors:
Nguyen TK, Rodriguez J-M, Wesselman HM, Wingert RA
Citation:
ISCIENCE (2024), doi.org/10.1016/j.isci.2024.111271
Epub:
Not Epub
Abstract:
Cilia are hair-like organelles with vital physiological roles, and ciliogenesis defects underlie a range of severe congenital...
Link:
https://www.sciencedirect.com/science/article/pii/S2589004224024969
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nguyen TK, Rodriguez J-M, Wesselman HM, Wingert RA. Emx2 is an essential regulator of ciliated cell development across embryonic tissues. ISCIENCE (2024), doi.org/10.1016/j.isci.2024.111271.

An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis

Authors:
Niu K, Zhang C, Liu C, Wu W, Yan Y, Zheng A, Liu S, Shi Z, Yang M, Wang W, Xiao Q
Citation:
Eur J Cell Biol. 2024 Dec;103(4):151465. doi: 10.1016/j.ejcb.2024.151465. Epub 2024 Oct 24. PMID: 39471724.
Epub:
Not Epub
Abstract:
Mesoderm induction is a crucial step for vascular cell specification, vascular development and vasculogenesis. However, the...
Link:
https://www.sciencedirect.com/science/article/pii/S0171933524000827
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Niu K, Zhang C, Liu C, Wu W, Yan Y, Zheng A, Liu S, Shi Z, Yang M, Wang W, Xiao Q. An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis. Eur J Cell Biol. 2024 Dec;103(4):151465. doi: 10.1016/j.ejcb.2024.151465. Epub 2024 Oct 24. PMID: 39471724..

PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation

Authors:
Song K, Chen D, Li J, Zhang J, Tian Y, Xu X, Wang B, Huang Z, Lou S, Kang J, Zhang N, Yang X, Ma W
Citation:
Adv Biol (Weinh). 2024 Oct 22:e2400307. doi: 10.1002/adbi.202400307. Online ahead of print. PMID: 39435597
Epub:
Not Epub
Abstract:
Oocyte meiotic errors can cause infertility, miscarriage, and birth defects. Here the role and the underlying mechanism of p21...
Link:
https://onlinelibrary.wiley.com/doi/10.1002/adbi.202400307
Delivery Method:
microinjection
Organism or Cell Type:
mouse oocysts
Citation Extract:
Song K, Chen D, Li J, Zhang J, Tian Y, Xu X, Wang B, Huang Z, Lou S, Kang J, Zhang N, Yang X, Ma W. PAK4 is Required for Meiotic Resumption, Spindle Assembly, and Cortical Migration in Mouse Oocytes During Meiotic Maturation. Adv Biol (Weinh). 2024 Oct 22:e2400307. doi: 10.1002/adbi.202400307. Online ahead of print. PMID: 39435597.

MMP21 behaves as a fluid flow transported morphogen to impart laterality during development

Authors:
Ott T, Brugger A, Szenker-Ravi E, Kurrle Y, Aberle O, Tisler M, Blum M, Whalen S, Bouvagnet P, Reversade B, Schweickert A
Citation:
eLife14:RP104430 (2025) https://doi.org/10.7554/eLife.104430.1
Epub:
Not Epub
Abstract:
Heterotaxy (HTX) is frequently caused by deleterious variants in the gene encoding Matrix metallopeptidase 21 (MMP21). However...
Link:
https://elifesciences.org/reviewed-preprints/104430v1
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Ott T, Brugger A, Szenker-Ravi E, Kurrle Y, Aberle O, Tisler M, Blum M, Whalen S, Bouvagnet P, Reversade B, Schweickert A. MMP21 behaves as a fluid flow transported morphogen to impart laterality during development. eLife14:RP104430 (2025) https://doi.org/10.7554/eLife.104430.1.

The evolutionary modifications of a GoLoco motif in the AGS protein facilitate micromere formation in the sea urchin embryo

Authors:
Emura N, Wavreil FDM, Fries A, Yajima M
Citation:
Elife. 2024 Dec 23;13:RP100086. doi: 10.7554/eLife.100086. PMID: 39714020; PMCID: PMC11666239
Epub:
Not Epub
Abstract:
The evolutionary introduction of asymmetric cell division (ACD) into the developmental program facilitates the formation of a...
Link:
https://elifesciences.org/articles/100086
Delivery Method:
microinjection
Organism or Cell Type:
Strongylocentrotus purpuratus (sea urchin), Eucidaris tribuloides (sea urchin), Patiria miniata (sea star)
Citation Extract:
Emura N, Wavreil FDM, Fries A, Yajima M. The evolutionary modifications of a GoLoco motif in the AGS protein facilitate micromere formation in the sea urchin embryo. Elife. 2024 Dec 23;13:RP100086. doi: 10.7554/eLife.100086. PMID: 39714020; PMCID: PMC11666239.

Zonated Wnt/β-catenin signal-activated cardiomyocytes at the atrioventricular canal promote coronary vessel formation in zebrafish

Authors:
Chiba A, Yamamoto T, Fukui H, Fukumoto M, Shirai M, Nakajima H, Mochizuki N
Citation:
Dev Cell. 2024 Oct 8:S1534-5807(24)00540-9. doi: 10.1016/j.devcel.2024.09.012. Epub ahead of print. PMID: 39395410
Epub:
Not Epub
Abstract:
Cells functioning at a specific zone by clustering according to gene expression are recognized as zonated cells. Here, we...
Link:
https://www.cell.com/developmental-cell/fulltext/S1534-5807(24)00540-9
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chiba A, Yamamoto T, Fukui H, Fukumoto M, Shirai M, Nakajima H, Mochizuki N. Zonated Wnt/β-catenin signal-activated cardiomyocytes at the atrioventricular canal promote coronary vessel formation in zebrafish. Dev Cell. 2024 Oct 8:S1534-5807(24)00540-9. doi: 10.1016/j.devcel.2024.09.012. Epub ahead of print. PMID: 39395410.

A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass

Authors:
Li S, Shao R, Li S, Zhao J, Deng Q, Li P, Wei Z, Xu S, Chen L, Li B, Zou W, Zhang Z
Citation:
Bone Res. 2024 Oct 16;12(1):60. doi: 10.1038/s41413-024-00364-2. PMID: 39414788
Epub:
Not Epub
Abstract:
Cellular communication network factor 2 (CCN2) is a secreted extracellular matrix-associated protein, and its aberrantly...
Link:
https://www.nature.com/articles/s41413-024-00364-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li S, Shao R, Li S, Zhao J, Deng Q, Li P, Wei Z, Xu S, Chen L, Li B, Zou W, Zhang Z. A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass. Bone Res. 2024 Oct 16;12(1):60. doi: 10.1038/s41413-024-00364-2. PMID: 39414788.

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