You are here

Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12195 scientific papers returned from the database with the search filters currently being used below.

Benzophenone-2 Disrupts Craniofacial Cartilage Development via esr2a-Dependent Inhibition of Endothelin Signaling in Zebrafish Larvae

Authors:
Xie Z, Li K, Zhou X, Wu Q, Zhou X, Zeng P, Li J, Niu Q, Qi Z, Zhao X, Song W
Citation:
Environ Res. 2026 May 22:124828. doi: 10.1016/j.envres.2026.124828. Epub ahead of print. PMID: 42176944
Epub:
Not Epub
Abstract:
Epidemiological evidence has linked early-life exposure to estrogenic endocrine-disrupting chemicals (e-EDCs) to craniofacial...
Link:
https://www.sciencedirect.com/science/article/abs/pii/S001393512601159X
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xie Z, Li K, Zhou X, Wu Q, Zhou X, Zeng P, Li J, Niu Q, Qi Z, Zhao X, Song W. Benzophenone-2 Disrupts Craniofacial Cartilage Development via esr2a-Dependent Inhibition of Endothelin Signaling in Zebrafish Larvae. Environ Res. 2026 May 22:124828. doi: 10.1016/j.envres.2026.124828. Epub ahead of print. PMID: 42176944.

Enhanced antisense oligonucleotide delivery reveals that transcript turnover impacts apparent splicing rescue in myotonic dystrophy

Authors:
Shea EN, Olafson HR, Muscato DR, Adams LM, Valero MC, McKee KK, Shen X, Dougherty PG, Hicks AN, Liu N, Kheirabadi M, Streeter M, Li X, Mon P, Girgenrath M, Sethuraman N, Qian Z, Wang ET
Citation:
Mol Ther. 2026 May 19:S1525-0016(26)00381-3. doi: 10.1016/j.ymthe.2026.04.060. Epub ahead of print. PMID: 42163456
Epub:
Not Epub
Abstract:
Steric-blocking antisense oligonucleotides rescue myotonic dystrophy type 1 phenotypes in preclinical models and are under...
Link:
https://www.cell.com/molecular-therapy-family/molecular-therapy/abstract/S1525-0016(26)00381-3
Delivery Method:
peptide-linked, intravenous (i.v.) injection
Organism or Cell Type:
HSALR mice
Citation Extract:
Shea EN, Olafson HR, Muscato DR, Adams LM, Valero MC, McKee KK, Shen X, Dougherty PG, Hicks AN, Liu N, Kheirabadi M, Streeter M, Li X, Mon P, Girgenrath M, Sethuraman N, Qian Z, Wang ET. Enhanced antisense oligonucleotide delivery reveals that transcript turnover impacts apparent splicing rescue in myotonic dystrophy. Mol Ther. 2026 May 19:S1525-0016(26)00381-3. doi: 10.1016/j.ymthe.2026.04.060. Epub ahead of print. PMID: 42163456.

Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis

Authors:
Vagena-Pantoula C, Kalyviotis K, Feng S, Sanchez A, Kondrychyn I, Fukumoto M, Pan X, Juan T, Stainier DYR, Pantazis P, Phng LK, Vermot J
Citation:
Sci Adv. 2026 Apr 24;12(17):eaea7025. doi: 10.1126/sciadv.aea7025. Epub 2026 Apr 22. PMID: 42018616; PMCID: PMC13101866
Epub:
Not Epub
Abstract:
Organ morphogenesis is driven by physical forces, yet how mechanical stimuli pattern tissue shape and guide developmental...
Link:
https://www.science.org/doi/10.1126/sciadv.aea7025
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Vagena-Pantoula C, Kalyviotis K, Feng S, Sanchez A, Kondrychyn I, Fukumoto M, Pan X, Juan T, Stainier DYR, Pantazis P, Phng LK, Vermot J. Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis. Sci Adv. 2026 Apr 24;12(17):eaea7025. doi: 10.1126/sciadv.aea7025. Epub 2026 Apr 22. PMID: 42018616; PMCID: PMC13101866.

ASO-based PKM splice-switching therapy increases anti-CTLA-4 antibody efficacy in pancreatic ductal adenocarcinoma

Authors:
Han L, Gan L, Schäfer B, Voss DM, Danielsen M, Kostov O, Liu J, Wang T, Caruthers MH, Chen H, Krainer AR
Citation:
Cell Discov. 2026 Apr 21;12(1):28. doi: 10.1038/s41421-026-00882-9. PMID: 42009652; PMCID: PMC13096517
Epub:
Not Epub
Abstract:
The alternative splice isoform of pyruvate kinase M (PKM), PKM2, plays a pivotal role in regulating aerobic glycolysis in tumor...
Link:
https://www.nature.com/articles/s41421-026-00882-9
Delivery Method:
thiomorpholino, Lipofectamine 3000 for cells, intraperitoneal (i.p.) injection for mice
Organism or Cell Type:
cell culture: SUIT-2, PANC-1, AsPC-1, Hs 766 T, BxPC-3, MIA PaCa-2; xenografted NU/J mice
Citation Extract:
Han L, Gan L, Schäfer B, Voss DM, Danielsen M, Kostov O, Liu J, Wang T, Caruthers MH, Chen H, Krainer AR. ASO-based PKM splice-switching therapy increases anti-CTLA-4 antibody efficacy in pancreatic ductal adenocarcinoma. Cell Discov. 2026 Apr 21;12(1):28. doi: 10.1038/s41421-026-00882-9. PMID: 42009652; PMCID: PMC13096517.

Quantitative live imaging reveals PRICKLE1 controls junctional neural tube morphogenesis independent of Planar Cell Polarity

Authors:
Wang JX, Alvarez YD, Tan SZ, Ranie SN, Stehbens SJ, White MD
Citation:
Nat Commun. 2026 Apr 27;17(1):3654. doi: 10.1038/s41467-026-71242-0. PMID: 42045189; PMCID: PMC13121753
Epub:
Not Epub
Abstract:
Neurulation, the process that forms the neural tube - the precursor to the brain and spinal cord - is frequently disrupted in...
Link:
https://www.nature.com/articles/s41467-026-71242-0
Delivery Method:
microinjection followed by electroporation
Organism or Cell Type:
quail embryo
Citation Extract:
Wang JX, Alvarez YD, Tan SZ, Ranie SN, Stehbens SJ, White MD. Quantitative live imaging reveals PRICKLE1 controls junctional neural tube morphogenesis independent of Planar Cell Polarity. Nat Commun. 2026 Apr 27;17(1):3654. doi: 10.1038/s41467-026-71242-0. PMID: 42045189; PMCID: PMC13121753.

Cfap300 regulates the transdifferentiation of Corpuscle of Stannius cells in zebrafish

Authors:
Nayak U, Sahoo K, Barrodia P, Swain RK
Citation:
Cell Commun Signal. 2026 May 1. doi: 10.1186/s12964-026-02912-1. Epub ahead of print. PMID: 42067934
Epub:
Not Epub
Abstract:
Background: Dynein axonemal assembly factors (DNAAF) are essential for the assembly and transport of dynein motor complexes,...
Link:
https://link.springer.com/article/10.1186/s12964-026-02912-1
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nayak U, Sahoo K, Barrodia P, Swain RK. Cfap300 regulates the transdifferentiation of Corpuscle of Stannius cells in zebrafish. Cell Commun Signal. 2026 May 1. doi: 10.1186/s12964-026-02912-1. Epub ahead of print. PMID: 42067934.

Splicing factor TRA2B enhances synthesis of androgen receptor variant AR-V7 in prostate cancer cells

Authors:
Brittain N, Paschalis A, Nelson R, Adamson B, Walker L, Duncan R, Smith GR, McGill S, Burchmore RJ, Bogdan D, Jiménez-Vacas JM, Welti J, Yuan W, Robson CN, Rescigno P, Luzzi S, Sharp A, de Bono J, Gaughan L
Citation:
J Clin Invest. 2026 Apr 1;136(7):e198264. doi: 10.1172/JCI198264. PMID: 41919500; PMCID: PMC13038199
Epub:
Not Epub
Abstract:
Treatment of locally advanced and metastatic prostate cancer (PC) with androgen receptor-targeting (AR-targeting) therapies has...
Link:
https://www.jci.org/articles/view/198264
Organism or Cell Type:
CWR22Rv1 cells
Citation Extract:
Brittain N, Paschalis A, Nelson R, Adamson B, Walker L, Duncan R, Smith GR, McGill S, Burchmore RJ, Bogdan D, Jiménez-Vacas JM, Welti J, Yuan W, Robson CN, Rescigno P, Luzzi S, Sharp A, de Bono J, Gaughan L. Splicing factor TRA2B enhances synthesis of androgen receptor variant AR-V7 in prostate cancer cells. J Clin Invest. 2026 Apr 1;136(7):e198264. doi: 10.1172/JCI198264. PMID: 41919500; PMCID: PMC13038199.

Studies on the anticonvulsant potential of 6-gingerol, an active ingredient of ginger rhizome

Authors:
Nieoczym D, Kukula-Koch W, Szafarz M, Vuong J, Grenda A, Tarabasz D, Pierog M, Marszalek-Grabska M, Szulc M, Esguerra CV, White HS and Gawel K
Citation:
Front. Pharmacol. (2026) 17:1740324. doi: 10.3389/fphar.2026.1740324
Epub:
Not Epub
Abstract:
Ginger (Zingiber officinale), due to its diverse therapeutic properties, continues to attract researchers’ attention. One of...
Link:
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1740324/full
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Nieoczym D, Kukula-Koch W, Szafarz M, Vuong J, Grenda A, Tarabasz D, Pierog M, Marszalek-Grabska M, Szulc M, Esguerra CV, White HS and Gawel K. Studies on the anticonvulsant potential of 6-gingerol, an active ingredient of ginger rhizome. Front. Pharmacol. (2026) 17:1740324. doi: 10.3389/fphar.2026.1740324.

Shear stress-induced Piezo1 activates CD99L2 to facilitate the initiation of blood circulation

Authors:
Lu J, Zhao J, Tang X, Zhu E, Xu J, Chen X, Wang Q, Huang Z, Ma N, Zhang W, Liu W
Citation:
Cell Rep. 2026 Mar 30;45(4):117200. doi: 10.1016/j.celrep.2026.117200. Epub ahead of print. PMID: 41915472
Epub:
Not Epub
Abstract:
The onset of blood circulation is a pivotal developmental event, yet the molecular mechanisms that enable erythrocytes to...
Link:
https://www.sciencedirect.com/science/article/pii/S2211124726002780
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lu J, Zhao J, Tang X, Zhu E, Xu J, Chen X, Wang Q, Huang Z, Ma N, Zhang W, Liu W. Shear stress-induced Piezo1 activates CD99L2 to facilitate the initiation of blood circulation. Cell Rep. 2026 Mar 30;45(4):117200. doi: 10.1016/j.celrep.2026.117200. Epub ahead of print. PMID: 41915472.

Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed

Authors:
Schöndorf T, Petrychenko V, Kotan I, Dahal D, Napieraj N, Cruz-Zaragoza LD, Wang C, Urbach O, Gall T, Dennerlein S, Kramer G, Fischer N, Rehling P
Citation:
Nat Struct Mol Biol. 2026 May 7. doi: 10.1038/s41594-026-01803-w. Epub ahead of print. PMID: 42098403
Epub:
Not Epub
Abstract:
The human mitochondrial genome encodes 13 subunits of the oxidative phosphorylation system essential for energy metabolism to...
Link:
https://www.nature.com/articles/s41594-026-01803-w
Delivery Method:
Jac1-conjugated PMO
Organism or Cell Type:
Purified mitochondria
Citation Extract:
Schöndorf T, Petrychenko V, Kotan I, Dahal D, Napieraj N, Cruz-Zaragoza LD, Wang C, Urbach O, Gall T, Dennerlein S, Kramer G, Fischer N, Rehling P. Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed. Nat Struct Mol Biol. 2026 May 7. doi: 10.1038/s41594-026-01803-w. Epub ahead of print. PMID: 42098403.

Pages