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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 280 scientific papers returned from the database with the search filters currently being used below.
There are 280 scientific papers returned from the database with the search filters currently being used below.
Arginine-rich Peptide conjugation to morpholino oligomers: effects on antisense activity and specificity
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Citation:
Bioconjug Chem. 2005 Jul-Aug;16(4):959-66 Epub:
Not Epub Abstract:
Noncharged antisense compounds, such as phosphorodiamidate morpholino oligomers (PMOs), do not readily enter mammalian cells in... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: HeLa Antisense Test System, others Citation Extract: Nelson MH, Stein DA, Kroeker AD, Hatlevig SA, Iversen PL, Moulton HM. Arginine-rich Peptide conjugation to morpholino oligomers: effects on antisense activity and specificity. Bioconjug Chem. 2005 Jul-Aug;16(4):959-66. |
Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors
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Citation:
Antimicrob Agents Chemother. 2011 Oct;55(10):4631-8. doi: 10.1128/AAC.00650-11. Epub 2011 Aug 8. PMID: 21825302; PMCID: PMC3186971 Epub:
Not Epub Abstract:
Members of the Arenaviridae are a threat to public health and can cause meningitis and hemorrhagic fever, yet treatment options... Delivery Method:
peptide-coupled Organism or Cell Type:
virus: Junín, Tacaribe, Pichinde and Lymphocytic Choriomeningitis arenavirus-infected cell cultures Citation Extract: Neuman BW, Bederka LH, Stein DA, Ting JP, Moulton HM, Buchmeier MJ. Development of peptide-conjugated morpholino oligomers as pan-arenavirus inhibitors. Antimicrob Agents Chemother. 2011 Oct;55(10):4631-8. doi: 10.1128/AAC.00650-11. Epub 2011 Aug 8. PMID: 21825302; PMCID: PMC3186971. |
Inhibition of KSHV-associated lymphoma engraftment in SCID mouse by morpholino oligomers
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Citation:
Infect Agent Cancer. 2010; 5(Suppl 1): A40. Epub 2010 Oct 11 Epub:
Not Epub Abstract:
Kaposi’s sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8, is associated with several malignant... Delivery Method:
peptide-coupled Organism or Cell Type:
mouse, SCID Citation Extract: Nan Y, Patel D, Zhang Y. Inhibition of KSHV-associated lymphoma engraftment in SCID mouse by morpholino oligomers. Infect Agent Cancer. 2010; 5(Suppl 1): A40. Epub 2010 Oct 11. |
Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers
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Citation:
J Virol. 2005 Aug;79(15):9665-76 Epub:
Not Epub Abstract:
The recently emerged severe acute respiratory syndrome coronavirus (SARS-CoV) is a potent pathogen of humans and is capable of... Delivery Method:
peptide-coupled Organism or Cell Type:
SARS virus Citation Extract: Neuman BW, Stein DA, Kroeker AD, Churchill MJ, Kim AM, Kuhn P, Dawson P, Moulton HM, Bestwick RK, Iversen PL, Buchmeier MJ. Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers. J Virol. 2005 Aug;79(15):9665-76. |
Peptide-morpholino conjugate: a promising therapeutic for Duchenne muscular dystrophy
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Citation:
Ann N Y Acad Sci. 2009 Sep;1175:55-60 Epub:
Not Epub Abstract:
Steric-blocking oligos can correct reading frame errors or skip premature termination codons. For Duchenne muscular dystrophy (... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx Citation Extract: Moulton HM, Wu B, Jearawiriyapaisarn N, Sazani P, Lu QL, Kole R. Peptide-morpholino conjugate: a promising therapeutic for Duchenne muscular dystrophy. Ann N Y Acad Sci. 2009 Sep;1175:55-60. |
Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo
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Citation:
Biochem Soc Trans. 2007 Aug;35(Pt 4):826-8 Epub:
Not Epub Abstract:
The cellular uptake of PMOs (phosphorodiamidate morpholino oligomers) can be enhanced by their conjugation to arginine-rich... Delivery Method:
peptide-coupled Organism or Cell Type:
mice (mdx), dog myoblasts Citation Extract: Moulton HM, Fletcher S, Neuman BW, McClorey G, Stein DA, Abes S, Wilton SD, Buchmeier MJ, Lebleu B, Iversen PL. Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo. Biochem Soc Trans. 2007 Aug;35(Pt 4):826-8. |
Cell-penetrating peptides enhance systemic delivery of antisense morpholino oligomers
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Citation:
Methods Mol Biol. 2012;867:407-14 Epub:
Not Epub Abstract:
Exon-skipping efficacy of phosphorodiamidate morpholino oligomers (Morpholinos) has been demonstrated in a proof-of-concept... Delivery Method:
peptide-coupled Organism or Cell Type:
mice, mdx and utrophin/dystrophin dKO Citation Extract: Moulton HM. Cell-penetrating peptides enhance systemic delivery of antisense morpholino oligomers. Methods Mol Biol. 2012;867:407-14. |
Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides
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Citation:
Bioconjug Chem. 2004 Mar-Apr;15(2):290-9 Epub:
Not Epub Abstract:
Although the sequence specificity, biostability, and low toxicity of PMO (phosphorodiamidate morpholino oligomers) make them... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: HeLa pLuc705 and NIH-3T3 cells Citation Extract: Moulton HM, Nelson MH, Hatlevig SA, Reddy MT, Iversen PL. Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides. Bioconjug Chem. 2004 Mar-Apr;15(2):290-9. |
Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function
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Citation:
Cancer Gene Ther. 2011 Oct 14. doi: 10.1038/cgt.2011.63. [Epub ahead of print] Epub:
Not Epub Abstract:
CD4+CD25+regulatory T cells (T(reg)) impair anti-tumor and anti-viral immunity. As there are higher T(reg) levels in cancer... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: CD4+CD25+regulatory T cells (Treg) Citation Extract: Morse MA, Hobeika A, Serra D, Aird K, McKinney M, Aldrich A, Clay T, Mourich D, Lyerly HK, Iversen PL, Devi GR. Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function. Cancer Gene Ther. 2011 Oct 14. doi: 10.1038/cgt.2011.63. [Epub ahead of print]. |
HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers
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Citation:
Antisense Nucleic Acid Drug Dev. 2003 Feb;13(1):31-43 Epub:
Not Epub Abstract:
Phosphorodiamidate morpholino oligomers (PMO) are uncharged antisense molecules that bind complementary sequences of RNA,... Delivery Method:
peptide-coupled Organism or Cell Type:
cell culture: various Hela Citation Extract: Moulton HM, Hase MC, Smith KM, Iversen PL. HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers. Antisense Nucleic Acid Drug Dev. 2003 Feb;13(1):31-43. |