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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12221 scientific papers returned from the database with the search filters currently being used below.
There are 12221 scientific papers returned from the database with the search filters currently being used below.
Electron Transfer Flavoprotein (ETF) α Controls Blood Vessel Development by Regulating Endothelial Mitochondrial Bioenergetics and Oxygen Consumption
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Citation:
Oxid Med Cell Longev. 2022;2022:7969916 [Epub] doi:10.1155/2022/7969916 Epub:
Yes Abstract:
While impairment of vascular homeostasis induced by hypercholesterolemia is the first step of cardiovascular diseases, the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Yan Y, Xu Y, Yang X, Li Z, Niu K, Liu C, Zhao M, Xiao Q,Wu W. Electron Transfer Flavoprotein (ETF) α Controls Blood Vessel Development by Regulating Endothelial Mitochondrial Bioenergetics and Oxygen Consumption. Oxid Med Cell Longev. 2022;2022:7969916 [Epub] doi:10.1155/2022/7969916. |
Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis
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Citation:
Nat Commun. 2023 Mar 1;14(1):1171. doi: 10.1038/s41467-023-36612-y. PMID: 36859431; PMCID: PMC9977867 Epub:
Not Epub Abstract:
Mesenchymal stromal cells are essential components of hematopoietic stem and progenitor cell (HSPC) niches, regulating HSPC... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Murayama E, Vivier C, Schmidt A, Herbomel P. Alcam-a and Pdgfr-α are essential for the development of sclerotome-derived stromal cells that support hematopoiesis. Nat Commun. 2023 Mar 1;14(1):1171. doi: 10.1038/s41467-023-36612-y. PMID: 36859431; PMCID: PMC9977867. |
Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling
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Citation:
Nat Neurosci. 2022;25:280-4. doi:10.1038/s41593-022-01023-7 Epub:
Not Epub Abstract:
Many oligodendrocyte precursor cells (OPCs) do not differentiate to form myelin, suggesting additional roles of this cell... Organism or Cell Type:
zebrafish Citation Extract: Xiao Y, Petrucco L, Hoodless LJ, Portugues R, Czopka T. Oligodendrocyte precursor cells sculpt the visual system by regulating axonal remodeling. Nat Neurosci. 2022;25:280-4. doi:10.1038/s41593-022-01023-7. |
The Fibrillin-1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells
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Citation:
Cancer Commun (Lond). 2022 Mar 2. doi: 10.1002/cac2.12274. Online ahead of print Epub:
Yes Abstract:
Background: Chemotherapy resistance is a primary reason of ovarian cancer therapy failure; hence it is important to investigate... Organism or Cell Type:
zebrafish Citation Extract: Wang Z, Chen W, Zuo L, Xu M, Wu Y, Huang J, Zhang X, Li Y, Wang J, Chen J, Wang H, Sun H. The Fibrillin-1/VEGFR2/STAT2 signaling axis promotes chemoresistance via modulating glycolysis and angiogenesis in ovarian cancer organoids and cells. Cancer Commun (Lond). 2022 Mar 2. doi: 10.1002/cac2.12274. Online ahead of print. |
The ciliary transition zone protein TMEM218 synergistically interacts with the NPHP module and its reduced dosage leads to a wide range of syndromic ciliopathies
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Citation:
Hum Mol Genet. 2022 Feb 6:ddac027. doi: 10.1093/hmg/ddac027. Online ahead of print Epub:
Not Epub Abstract:
Mutations in genes that lead to dysfunctional cilia can cause a broad spectrum of human disease phenotypes referred to as... Organism or Cell Type:
zebrafish Citation Extract: Epting D, Decker E, Ott E, Eisenberger T, Bader I, Bachmann N, Bergmann C. The ciliary transition zone protein TMEM218 synergistically interacts with the NPHP module and its reduced dosage leads to a wide range of syndromic ciliopathies. Hum Mol Genet. 2022 Feb 6:ddac027. doi: 10.1093/hmg/ddac027. Online ahead of print. |
Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis
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Citation:
eLife. 2022;11:e74821. doi:10.7554/eLife.74821 Epub:
Not Epub Abstract:
Angioblasts that form the major axial blood vessels of the dorsal aorta and cardinal vein migrate toward the embryonic midline... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Paulissen E, Palmisano NJ, Waxman JS, Martin BL. Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis. eLife. 2022;11:e74821. doi:10.7554/eLife.74821. |
Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model
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Citation:
Mol Ther Nucleic Acids. 2022:[Epub ahead of print] doi:10.1016/j.omtn.2022.02.003 Epub:
Yes Abstract:
Myotonic dystrophy type 1 is a debilitating neuromuscular disease causing muscle weakness, myotonia, and cardiac dysfunction.... Delivery Method:
Pip9b2 peptide-linked; intravenous (i.v.) Organism or Cell Type:
DM1 cells; HSALR mice Citation Extract: Overby SJ, Cerro-Herreros E, González-Martínez I, Varela MA, Seoane-Miraz D, Jad Y, Raz R, Møller T, Pérez-Alonso M, Wood MJ, Llamusí B, Artero R. Proof of concept of peptide-linked blockmiR-induced MBNL functional rescue in myotonic dystrophy type 1 mouse model. Mol Ther Nucleic Acids. 2022:[Epub ahead of print] doi:10.1016/j.omtn.2022.02.003. |
Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity
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Citation:
ACS Bio Med Chem Au. 2022 Feb 16;2(2):150-160. doi: 10.1021/acsbiomedchemau.1c00053. PMID: 37101743; PMCID: PMC10114648 Epub:
Yes Abstract:
Cell-penetrating peptides (CPPs) can cross the cell membrane to enter the cytosol and deliver otherwise nonpenetrant... Delivery Method:
peptide-linked Organism or Cell Type:
cell culture: HeLa 654 Citation Extract: Schissel CK, Farquhar CE, Malmberg AB, Loas A, Pentelute BL. Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity. ACS Bio Med Chem Au. 2022 Feb 16;2(2):150-160. doi: 10.1021/acsbiomedchemau.1c00053. PMID: 37101743; PMCID: PMC10114648. |
Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers
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Citation:
Nature. 2022 Mar 2. doi: 10.1038/s41586-022-04451-4. Online ahead of print Epub:
Yes Abstract:
RAS family members are the most frequently mutated oncogenes in human cancers. Although KRAS(G12C)-specific inhibitors show... Delivery Method:
Vivo-Morpholino Organism or Cell Type:
xenograft in mice Citation Extract: Kobayashi Y, Chhoeu C, Li J, Price KS, Kiedrowski LA, Hutchins JL, Hardin AI, Wei Z, Hong F, Bahcall M, Gokhale PC, Jänne PA. Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers. Nature. 2022 Mar 2. doi: 10.1038/s41586-022-04451-4. Online ahead of print. |
Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish
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Citation:
Mol Neurobiol. 2022 Mar 4. doi: 10.1007/s12035-022-02783-w. Online ahead of print Epub:
Yes Abstract:
In mammals, photoreceptor loss causes permanent blindness, but in zebrafish (Danio rerio), photoreceptor loss reprograms Müller... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Magner E, Sandoval-Sanchez P, Kramer AC, Thummel R, Hitchcock PF, Taylor SM. Disruption of miR-18a Alters Proliferation, Photoreceptor Replacement Kinetics, Inflammatory Signaling, and Microglia/Macrophage Numbers During Retinal Regeneration in Zebrafish. Mol Neurobiol. 2022 Mar 4. doi: 10.1007/s12035-022-02783-w. Online ahead of print. |