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Morpholino Publication Database
This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.
There are 12221 scientific papers returned from the database with the search filters currently being used below.
There are 12221 scientific papers returned from the database with the search filters currently being used below.
Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans
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Citation:
Redox Biol. 2020;101723. doi:10.1016/j.redox.2020.101723 Epub:
Not Epub Abstract:
Increased methylglyoxal (MG) formation is associated with diabetes and its complications. In zebrafish, knockout of the main MG... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lou B, Boger M, Bennewitz K, Sticht C, Kopf S, Morgenstern J, Fleming T, Hell R, Yuan Z, Nawroth PP, Kroll J. Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biol. 2020;101723. doi:10.1016/j.redox.2020.101723. |
Knockdown of Gene Expression Following Activation of the NMD Pathway Using Splice-Switching Oligonucleotides
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Citation:
Methods Mol Biol. 2025;2962:237-253. doi: 10.1007/978-1-0716-4726-4_16. PMID: 40699433 Epub:
Not Epub Abstract:
Antisense oligonucleotides (ASOs) are commonly used to induce transient changes in gene expression and do not result in... Delivery Method:
Vivo-Morpholino versus "transfection" of standard Morpholinos Organism or Cell Type:
cell culture: SUDHL4 and OCILY10 (DLBCL) lines, primary Human Peripheral Blood Mononuclear B Cells (PBMC) Citation Extract: Hirt P, Marchalot A, Horiot C, Moreaux J, Delpy L. Knockdown of Gene Expression Following Activation of the NMD Pathway Using Splice-Switching Oligonucleotides. Methods Mol Biol. 2025;2962:237-253. doi: 10.1007/978-1-0716-4726-4_16. PMID: 40699433. |
Molluskan Dorsal-Ventral Patterning Relying on BMP2/4 and Chordin Provides Insights into Spiralian Development and Evolution
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Citation:
Mol Biol Evol. 2022 Jan 7;39(1):msab322. doi: 10.1093/molbev/msab322. PMID: 34751376; PMCID: PMC8789067 Epub:
Not Epub Abstract:
Although a conserved mechanism relying on BMP2/4 and Chordin is suggested for animal dorsal-ventral (DV) patterning, this... Delivery Method:
microinjection Organism or Cell Type:
Lottia goshimai (limpet) Citation Extract: Tan S, Huan P, Liu B. Molluskan Dorsal-Ventral Patterning Relying on BMP2/4 and Chordin Provides Insights into Spiralian Development and Evolution. Mol Biol Evol. 2022 Jan 7;39(1):msab322. doi: 10.1093/molbev/msab322. PMID: 34751376; PMCID: PMC8789067. |
Control of dynamic cell behaviors during angiogenesis and anastomosis by Rasip1
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Citation:
Development. 2021 Aug 1;148(15):dev197509. doi: 10.1242/dev.197509. Epub 2021 Aug 12. PMID: 34383884; PMCID: PMC8380458 Epub:
Not Epub Abstract:
Organ morphogenesis is driven by a wealth of tightly orchestrated cellular behaviors, which ensure proper organ assembly and... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Lee M, Betz C, Yin J, Paatero I, Schellinx N, Carte AN, Wilson CW, Ye W, Affolter M, Belting HG. Control of dynamic cell behaviors during angiogenesis and anastomosis by Rasip1. Development. 2021 Aug 1;148(15):dev197509. doi: 10.1242/dev.197509. Epub 2021 Aug 12. PMID: 34383884; PMCID: PMC8380458. |
The Wnt/PCP formin Daam1 drives cell-cell adhesion during nephron development
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Citation:
Cell Rep. 2021 Jul 6;36(1):109340. doi: 10.1016/j.celrep.2021.109340. PMID: 34233186; PMCID: PMC8629027 Epub:
Not Epub Abstract:
E-cadherin junctions facilitate assembly and disassembly of cell contacts that drive development and homeostasis of epithelial... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Krneta-Stankic V, Corkins ME, Paulucci-Holthauzen A, Kloc M, Gladden AB, Miller RK. The Wnt/PCP formin Daam1 drives cell-cell adhesion during nephron development. Cell Rep. 2021 Jul 6;36(1):109340. doi: 10.1016/j.celrep.2021.109340. PMID: 34233186; PMCID: PMC8629027. |
Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk
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Citation:
Elife. 2019 Apr 30;8:e42881. doi: 10.7554/eLife.42881 Epub:
Not Epub Abstract:
Lymphatic vascular development involves specification of lymphatic endothelial progenitors that subsequently undergo sprouting... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Grimm L, Nakajima H, Chaudhury S, Bower NI, Okuda KS, Cox AG, Harvey NL, Koltowska K, Mochizuki N, Hogan BM. Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk. Elife. 2019 Apr 30;8:e42881. doi: 10.7554/eLife.42881. |
Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis
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Citation:
PLoS Genet. 2021 Apr 5;17(4):e1009112. doi: 10.1371/journal.pgen.1009112. PMID: 33819264; PMCID: PMC8049494 Epub:
Not Epub Abstract:
We previously identified a deletion on chromosome 16p12.1 that is mostly inherited and associated with multiple... Delivery Method:
microinjection Organism or Cell Type:
Xenopus laevis Citation Extract: Pizzo L, Lasser M, Yusuff T, Jensen M, Ingraham P, Huber E, Singh MD, Monahan C, Iyer J, Desai I, Karthikeyan S, Gould DJ, Yennawar S, Weiner AT, Pounraja VK, Krishnan A, Rolls MM, Lowery LA, Girirajan S. Functional assessment of the "two-hit" model for neurodevelopmental defects in Drosophila and X. laevis. PLoS Genet. 2021 Apr 5;17(4):e1009112. doi: 10.1371/journal.pgen.1009112. PMID: 33819264; PMCID: PMC8049494. |
TRIM28 regulates sprouting angiogenesis through VEGFR-DLL4-Notch signaling circuit
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Citation:
FASEB J. 2020 Sep 12. doi: 10.1096/fj.202000186RRR. Online ahead of print Epub:
Yes Abstract:
Sprouting angiogenesis is a highly coordinately process controlled by vascular endothelial growth factor receptor (VEGFR)-Notch... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Wang Y, Singh AR, Zhao Y, Du T, Huang Y, Wan X, Mukhopadhyay D, Wang Y, Wang N, Zhang P. TRIM28 regulates sprouting angiogenesis through VEGFR-DLL4-Notch signaling circuit. FASEB J. 2020 Sep 12. doi: 10.1096/fj.202000186RRR. Online ahead of print. |
Metformin-induced suppression of NLK improves erythropoiesis in pre-clinical models of Diamond Blackfan Anemia through induction of miR-26a
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Citation:
Exp Hematol. 2020 Sep 11:S0301-472X(20)30552-X. doi: 10.1016/j.exphem.2020.09.187. Online ahead of print Epub:
Not Epub Abstract:
Diamond Blackfan Anemia (DBA) results from haploinsufficiency of ribosomal protein subunits in hematopoietic progenitors in the... Delivery Method:
microinjection Organism or Cell Type:
zebrafish Citation Extract: Wilkes MC, Siva K, Varetti G, Mercado J, Wentworth EP, Perez C, Saxena M, Kam S, Kapur S, Chen J, Narla A, Glader B, Lin S, Serrano M, Flygare J, Sakamoto KM. Metformin-induced suppression of NLK improves erythropoiesis in pre-clinical models of Diamond Blackfan Anemia through induction of miR-26a. Exp Hematol. 2020 Sep 11:S0301-472X(20)30552-X. doi: 10.1016/j.exphem.2020.09.187. Online ahead of print. |
In vivo Pharmacokinetic and Biodistribution profile of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides
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Citation:
Poster at 2015 Oligonucleotide Therapeutics Society meeting Epub:
Not Epub Abstract:
Antisense oligonucleotide (AON) induced exon skipping is one of the most promising strategies for treating Duchene muscular... Delivery Method:
Pip6A peptide-linked; subcutaneous (s.c.) or intravenous (i.v.) Organism or Cell Type:
mdx mice Citation Extract: Burki U, Blain A, Greally E, O’Donovan L, Gait M, Laval S, Straub V. In vivo Pharmacokinetic and Biodistribution profile of Peptide-Conjugated Phosphorodiamidate Morpholino Oligonucleotides. Poster at 2015 Oligonucleotide Therapeutics Society meeting. |