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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12383 scientific papers returned from the database with the search filters currently being used below.

Divergent roles of the Wnt/PCP Formin Daam1 in renal ciliogenesis

Authors:
Corkins ME, Krneta-Stankic V, Kloc M, McCrea PD, Gladden AB, Miller RK
Citation:
PLoS ONE. 2019;14(8):e0221698. doi:10.1371/journal.pone.0221698
Epub:
Not Epub
Abstract:
Kidneys are composed of numerous ciliated epithelial tubules called nephrons. Each nephron functions to reabsorb nutrients and...
Link:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0221698
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Corkins ME, Krneta-Stankic V, Kloc M, McCrea PD, Gladden AB, Miller RK. Divergent roles of the Wnt/PCP Formin Daam1 in renal ciliogenesis. PLoS ONE. 2019;14(8):e0221698. doi:10.1371/journal.pone.0221698.

ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients

Authors:
Xie Y, Gao L, Xu C, Chu L, Gao L, Wu R, Liu Y, Liu T, Sun XJ, Ren R, Tang J, Zheng Y, Zhou Y, Shen S
Citation:
Haematologica. 2019 Aug 29. pii: haematol.2018.210286. doi: 10.3324/haematol.2018.210286. [Epub ahead of print]
Epub:
Yes
Abstract:
Hematopoiesis is a finely regulated process in vertebrates under both homeostatic and stress conditions. By whole exome...
Link:
http://www.haematologica.org/content/early/2019/08/26/haematol.2018.210286.long
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Xie Y, Gao L, Xu C, Chu L, Gao L, Wu R, Liu Y, Liu T, Sun XJ, Ren R, Tang J, Zheng Y, Zhou Y, Shen S. ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica. 2019 Aug 29. pii: haematol.2018.210286. doi: 10.3324/haematol.2018.210286. [Epub ahead of print].

Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion

Authors:
Lekszas C, Foresti O, Raote I, Liedtke D, König EM, Nanda I, Vona B, De Coster P, Cauwels R, Malhotra V, Haaf T
Citation:
Elife. 2020 Feb 26;9:e51319. doi: 10.7554/eLife.51319. PMID: 32101163; PMCID: PMC7062462
Epub:
Not Epub
Abstract:
The transport and Golgi organization 1 (TANGO1) proteins play pivotal roles in the secretory pathway. Full length TANGO1 is a...
Link:
https://elifesciences.org/articles/51319
Delivery Method:
FuGENE HD transfection reagent
Organism or Cell Type:
cell culture: HeLa
Citation Extract:
Lekszas C, Foresti O, Raote I, Liedtke D, König EM, Nanda I, Vona B, De Coster P, Cauwels R, Malhotra V, Haaf T. Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion. Elife. 2020 Feb 26;9:e51319. doi: 10.7554/eLife.51319. PMID: 32101163; PMCID: PMC7062462.

Sema3E is required for migration of cranial neural crest cells in zebrafish: Implications for the pathogenesis of CHARGE syndrome

Authors:
Liu ZZ, Guo J, Lu Y, Liu W, Fu X, Yao T, Zhou Y, Xu HA
Citation:
Int J Exp Pathol. 2019 Aug 28. doi: 10.1111/iep.12331. [Epub ahead of print]
Epub:
Yes
Abstract:
CHARGE syndrome is a congenital disorder with multiple malformations in the craniofacial structures, and cardiovascular and...
Link:
https://onlinelibrary.wiley.com/doi/abs/10.1111/iep.12331
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Liu ZZ, Guo J, Lu Y, Liu W, Fu X, Yao T, Zhou Y, Xu HA. Sema3E is required for migration of cranial neural crest cells in zebrafish: Implications for the pathogenesis of CHARGE syndrome. Int J Exp Pathol. 2019 Aug 28. doi: 10.1111/iep.12331. [Epub ahead of print].

Genetic compensation by epob in pronephros development in epoa mutant zebrafish

Authors:
She J, Wu Y, Lou B, Lodd E, Klems A, Schmoehl F, Yuan Z, Noble FL, Kroll J
Citation:
Cell Cycle. 2019 Aug 26:1-14. doi: 10.1080/15384101.2019.1656019. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Zebrafish erythropoietin a (epoa) is a well characterized regulator of red blood cell formation. Recent morpholino mediated...
Link:
https://www.tandfonline.com/doi/full/10.1080/15384101.2019.1656019
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
She J, Wu Y, Lou B, Lodd E, Klems A, Schmoehl F, Yuan Z, Noble FL, Kroll J. Genetic compensation by epob in pronephros development in epoa mutant zebrafish. Cell Cycle. 2019 Aug 26:1-14. doi: 10.1080/15384101.2019.1656019. [Epub ahead of print].

Gene silencing through RNAi and antisense Vivo-Morpholino increases the efficacy of pyrethroids on larvae of Anopheles stephensi

Authors:
Negri A, Ferrari M, Nodari R, Coppa E, Mastrantonio V, Zanzani S, Porretta D, Bandi C, Urbanelli S, Epis S
Citation:
Malar J. 2019;18:294. doi:10.1186/s12936-019-2925-5
Epub:
Not Epub
Abstract:
Background: Insecticides are still at the core of insect pest and vector control programmes. Several lines of evidence indicate...
Link:
https://malariajournal.biomedcentral.com/articles/10.1186/s12936-019-2925-5
Delivery Method:
Vivo-Morpholino bathing
Organism or Cell Type:
Anopheles stephensi (mosquito)
Citation Extract:
Negri A, Ferrari M, Nodari R, Coppa E, Mastrantonio V, Zanzani S, Porretta D, Bandi C, Urbanelli S, Epis S. Gene silencing through RNAi and antisense Vivo-Morpholino increases the efficacy of pyrethroids on larvae of Anopheles stephensi. Malar J. 2019;18:294. doi:10.1186/s12936-019-2925-5.

A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish

Authors:
Lee G-H, Chang C-L, Chiu W-T, Hsiao T-S, Chen P-Y, Wang K-C, Kuo C-H, Chen B-H, Shi G-Y, Wu H-L, Fu T-F
Citation:
J Biomed Sci. 2019;26(1):60. doi:10.1186/s12929-019-0549-2
Epub:
Not Epub
Abstract:
Background: Thrombomodulin (TM), an integral membrane protein, has long been known for its anticoagulant activity. Recent...
Link:
https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-019-0549-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lee G-H, Chang C-L, Chiu W-T, Hsiao T-S, Chen P-Y, Wang K-C, Kuo C-H, Chen B-H, Shi G-Y, Wu H-L, Fu T-F. A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish. J Biomed Sci. 2019;26(1):60. doi:10.1186/s12929-019-0549-2.

Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis

Authors:
Wade SM, Ohnesorge N, McLoughlin H, Biniecka M, Carter SP, Trenkman M, Cunningham CC, McGarry T, Canavan M, Kennedy BN, Veale DJ, Fearon U
Citation:
EBioMedicine. 2019;[Epub ahead of print] doi:10.1016/j.ebiom.2019.08.043
Epub:
Yes
Abstract:
Background: Although neoangiogenesis is a hallmark of chronic inflammatory diseases such as inflammatory arthritis and many...
Link:
https://www.ebiomedicine.com/article/S2352-3964(19)30566-3/abstract
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Wade SM, Ohnesorge N, McLoughlin H, Biniecka M, Carter SP, Trenkman M, Cunningham CC, McGarry T, Canavan M, Kennedy BN, Veale DJ, Fearon U. Dysregulated miR-125a promotes angiogenesis through enhanced glycolysis. EBioMedicine. 2019;[Epub ahead of print] doi:10.1016/j.ebiom.2019.08.043.

Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal

Authors:
Di Bella DJ, Carcagno AL, Bartolomeu ML, Pardi MB, Löhr H, Siegel N, Hammerschmidt M, Marín-Burgin A, Lanuza GM
Citation:
Cell Rep. 2019;28(9):2264-74. doi:10.1016/j.celrep.2019.07.087
Epub:
Not Epub
Abstract:
Generation of neuronal types at the right time, location, and number is essential for building a functional nervous system....
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(19)31003-4
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Di Bella DJ, Carcagno AL, Bartolomeu ML, Pardi MB, Löhr H, Siegel N, Hammerschmidt M, Marín-Burgin A, Lanuza GM. Ascl1 Balances Neuronal versus Ependymal Fate in the Spinal Cord Central Canal. Cell Rep. 2019;28(9):2264-74. doi:10.1016/j.celrep.2019.07.087.

Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy

Authors:
Fadzen CM, Holden RL, Wolfe JM, Choo ZN, Schissel CK, Yao M, Hanson GJ, Pentelute BL
Citation:
Biochemistry. 2019 Sep 24;58(38):3980-3989. doi: 10.1021/acs.biochem.9b00413. Epub 2019 Sep 6. PMID: 31450889
Epub:
Yes
Abstract:
Phosphorodiamidate morpholino oligonucleotides (PMOs) make up a promising class of therapeutics for genetic disease. PMOs...
Link:
https://pubs.acs.org/doi/pdf/10.1021/acs.biochem.9b00413
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: HeLa-654
Citation Extract:
Fadzen CM, Holden RL, Wolfe JM, Choo ZN, Schissel CK, Yao M, Hanson GJ, Pentelute BL. Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy. Biochemistry. 2019 Sep 24;58(38):3980-3989. doi: 10.1021/acs.biochem.9b00413. Epub 2019 Sep 6. PMID: 31450889.

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