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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12485 scientific papers returned from the database with the search filters currently being used below.

The methyltransferase HEN1 is required in Nematostella vectensis for microRNA and piRNA stability as well as larval metamorphosis

Authors:
Modepalli V, Fridrich A, Agron M, Moran Y
Citation:
PLoS Genet. 2018 Aug 17;14(8):e1007590. doi: 10.1371/journal.pgen.1007590. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Small non-coding RNAs (sRNAs) such as microRNAs (miRNAs), small interfering RNAs (siRNAs) and piwi-interacting RNAs (piRNAs)...
Link:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007590
Delivery Method:
microinjection
Organism or Cell Type:
Nematostella vectensis (sea anemone)
Citation Extract:
Modepalli V, Fridrich A, Agron M, Moran Y. The methyltransferase HEN1 is required in Nematostella vectensis for microRNA and piRNA stability as well as larval metamorphosis. PLoS Genet. 2018 Aug 17;14(8):e1007590. doi: 10.1371/journal.pgen.1007590. [Epub ahead of print].

A novel ZIC3 gene mutation identified in patients with heterotaxy and congenital heart disease

Authors:
Li S, Liu S, Chen W, Yuan Y, Gu R, Song Y, Li J, Cao Y, Lin Y, Xu J, Wang H, Ma D, Ma X, Sheng W, Huang G
Citation:
Sci Rep. 2018 Aug 17;8(1):12386. doi: 10.1038/s41598-018-30204-3
Epub:
Not Epub
Abstract:
Heterotaxy syndrome (HTX) is characterized by left-right (LR) asymmetry disturbances associated with severe heart malformations...
Link:
https://www.nature.com/articles/s41598-018-30204-3
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li S, Liu S, Chen W, Yuan Y, Gu R, Song Y, Li J, Cao Y, Lin Y, Xu J, Wang H, Ma D, Ma X, Sheng W, Huang G. A novel ZIC3 gene mutation identified in patients with heterotaxy and congenital heart disease. Sci Rep. 2018 Aug 17;8(1):12386. doi: 10.1038/s41598-018-30204-3.

Inhibiting neutral amino acid transport for the treatment of phenylketonuria

Authors:
Belanger AM, Przybylska M, Gefteas E, Furgerson M, Geller S, Kloss A, Cheng SH, Zhu Y, Yew NS
Citation:
JCI Insight. 2018 Jul 26;3(14). pii: 121762. doi: 10.1172/jci.insight.121762. [Epub ahead of print]
Epub:
Not Epub
Abstract:
The neuropathological effects of phenylketonuria (PKU) stem from the inability of the body to metabolize excess phenylalanine (...
Link:
https://insight.jci.org/articles/view/121762
Delivery Method:
Endo-Porter in culture, (RxR)4 peptide-linked in mice by intravenous (i.v.) injection
Organism or Cell Type:
primary mouse renal tubular epithelial cells; Pahenu2 mice
Citation Extract:
Belanger AM, Przybylska M, Gefteas E, Furgerson M, Geller S, Kloss A, Cheng SH, Zhu Y, Yew NS. Inhibiting neutral amino acid transport for the treatment of phenylketonuria. JCI Insight. 2018 Jul 26;3(14). pii: 121762. doi: 10.1172/jci.insight.121762. [Epub ahead of print].

Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking

Authors:
Kondo Y, Fu J, Wang H, Hoover C, McDaniel JM, Steet R, Patra D, Song J, Pollard L, Cathey S, Yago T, Wiley G, Macwana S, Guthridge J, McGee S, Li S, Griffin C, Furukawa K, James JA, Ruan C, McEver RP, Wierenga KJ, Gaffney PM, Xia L
Citation:
JCI Insight. 2018 Jul 26;3(14). pii: 121596. doi: 10.1172/jci.insight.121596. [Epub ahead of print]
Epub:
Not Epub
Abstract:
Site-1 protease (S1P), encoded by MBTPS1, is a serine protease in the Golgi. S1P regulates lipogenesis, endoplasmic reticulum (...
Link:
https://insight.jci.org/articles/view/121596
Delivery Method:
Endo-Porter
Organism or Cell Type:
cell culture: human primary fibroblasts, immortalized
Citation Extract:
Kondo Y, Fu J, Wang H, Hoover C, McDaniel JM, Steet R, Patra D, Song J, Pollard L, Cathey S, Yago T, Wiley G, Macwana S, Guthridge J, McGee S, Li S, Griffin C, Furukawa K, James JA, Ruan C, McEver RP, Wierenga KJ, Gaffney PM, Xia L. Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking. JCI Insight. 2018 Jul 26;3(14). pii: 121596. doi: 10.1172/jci.insight.121596. [Epub ahead of print].

Dkk2 promotes neural crest specification by activating Wnt/β-catenin signaling in a GSK3β independent manner

Authors:
Devotta A, Hong CS, Saint-Jeannet JP
Citation:
Elife. 2018 Jul 23;7. pii: e34404. doi: 10.7554/eLife.34404
Epub:
Not Epub
Abstract:
Neural crest progenitors are specified through the modulation of several signaling pathways, among which the activation of Wnt/...
Link:
https://elifesciences.org/articles/34404
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Devotta A, Hong CS, Saint-Jeannet JP. Dkk2 promotes neural crest specification by activating Wnt/β-catenin signaling in a GSK3β independent manner. Elife. 2018 Jul 23;7. pii: e34404. doi: 10.7554/eLife.34404.

Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis

Authors:
Page DJ, Thuret R, Venkatraman L, Takahashi T, Bentley K, Herbert SP
Citation:
Cell Rep. 2019 Jun 11;27(11):3139-3151.e5. doi: 10.1016/j.celrep.2019.05.052. PMID: 31189101; PMCID: PMC6581738
Epub:
Not Epub
Abstract:
Angiogenesis is driven by the coordinated collective branching of specialized leading "tip" and trailing "stalk...
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC6581738/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Page DJ, Thuret R, Venkatraman L, Takahashi T, Bentley K, Herbert SP. Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Rep. 2019 Jun 11;27(11):3139-3151.e5. doi: 10.1016/j.celrep.2019.05.052. PMID: 31189101; PMCID: PMC6581738.

A gene regulatory network underlying the formation of pre-placodal ectoderm in Xenopus laevis

Authors:
Maharana SK, Schlosser G
Citation:
BMC Biol. 2018 Jul 16;16(1):79. doi: 10.1186/s12915-018-0540-5
Epub:
Not Epub
Abstract:
BACKGROUND: The neural plate border ectoderm gives rise to key developmental structures during embryogenesis, including the...
Link:
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0540-5
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus laevis
Citation Extract:
Maharana SK, Schlosser G. A gene regulatory network underlying the formation of pre-placodal ectoderm in Xenopus laevis. BMC Biol. 2018 Jul 16;16(1):79. doi: 10.1186/s12915-018-0540-5.

Elesclomol restores mitochondrial function in genetic models of copper deficiency

Authors:
Soma S, Latimer AJ, Chun H, Vicary AC, Timbalia SA, Boulet A, Rahn JJ, Chan SSL, Leary SC, Kim BE, Gitlin JD, Gohil VM
Citation:
Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8161-8166. doi: 10.1073/pnas.1806296115. Epub 2018 Jul 23
Epub:
Not Epub
Abstract:
Copper is an essential cofactor of cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial respiratory chain....
Link:
http://www.pnas.org/content/pnas/early/2018/07/17/1806296115.full.pdf
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Soma S, Latimer AJ, Chun H, Vicary AC, Timbalia SA, Boulet A, Rahn JJ, Chan SSL, Leary SC, Kim BE, Gitlin JD, Gohil VM. Elesclomol restores mitochondrial function in genetic models of copper deficiency. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8161-8166. doi: 10.1073/pnas.1806296115. Epub 2018 Jul 23.

The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis

Authors:
Dickover M, Hegarty JM, Ly K, Lopez D, Yang H, Zhang R, Tedeschi N, Hsiai TK, Chi NC
Citation:
Dev Biol. 2014 May 15;389(2):182-91. doi: 10.1016/j.ydbio.2014.02.014. Epub 2014 Mar 7
Epub:
Not Epub
Abstract:
The vertebrate heart undergoes early complex morphologic events in order to develop key cardiac structures that regulate its...
Link:
https://www.sciencedirect.com/science/article/pii/S0012160614000943
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Dickover M, Hegarty JM, Ly K, Lopez D, Yang H, Zhang R, Tedeschi N, Hsiai TK, Chi NC. The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis. Dev Biol. 2014 May 15;389(2):182-91. doi: 10.1016/j.ydbio.2014.02.014. Epub 2014 Mar 7.

Cerebral Cavernous Malformation 1/2 complex controls ROCK1 and ROCK2 complementary functions for endothelial integrity

Authors:
Lisowska J, Rödel CJ, Manet S, Miroshnikova YA, Boyault C, Planus E, De Mets R, Lee H-H, Destaing O, Mertani H, Boulday G, Tournier-Lasserve E, Balland M, Abdelilah-Seyfried S, Albiges-Rizo C, Faurobert E.
Citation:
J Cell Sci. 2018;[Epub] doi:10.1242/jcs.216093
Epub:
Yes
Abstract:
Endothelial integrity relies on a mechanical crosstalk between intercellular and cell-matrix interactions. This cross-talk is...
Link:
http://jcs.biologists.org/content/early/2018/07/19/jcs.216093
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Lisowska J, Rödel CJ, Manet S, Miroshnikova YA, Boyault C, Planus E, De Mets R, Lee H-H, Destaing O, Mertani H, Boulday G, Tournier-Lasserve E, Balland M, Abdelilah-Seyfried S, Albiges-Rizo C, Faurobert E. . Cerebral Cavernous Malformation 1/2 complex controls ROCK1 and ROCK2 complementary functions for endothelial integrity. J Cell Sci. 2018;[Epub] doi:10.1242/jcs.216093.

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