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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12146 scientific papers returned from the database with the search filters currently being used below.

Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution

Authors:
Uveira J, Donati A, Léria M, Lechable M, Lahaye F, Vesque C, Houliston E, Momose T
Citation:
Elife. 2025 Jul 2;14:RP104508. doi: 10.7554/eLife.104508. PMID: 40600800; PMCID: PMC12221298
Epub:
Not Epub
Abstract:
Body axis specification is a crucial event in animal embryogenesis and was an essential evolutionary innovation for founding...
Link:
https://elifesciences.org/articles/104508
Delivery Method:
microinjection
Organism or Cell Type:
Clytia hemisphaerica
Citation Extract:
Uveira J, Donati A, Léria M, Lechable M, Lahaye F, Vesque C, Houliston E, Momose T. Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution. Elife. 2025 Jul 2;14:RP104508. doi: 10.7554/eLife.104508. PMID: 40600800; PMCID: PMC12221298.

Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA

Authors:
Sakai A, Singh G, Khoshbakht M, Bittner S, Löhr CV, Diaz-Tapia R, Warang P, White K, Le Luo L, Tolbert B, Blanco M, Chow A, Guttman M, Li C, Bao Y, Ho J, Maurer-Stroh S, Chatterjee A, Chanda S, García-Sastre A, Schotsaert M, Teijaro JR, Moulton HM, Stein DA
Citation:
Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102331
Epub:
Not Epub
Abstract:
Further development of direct-acting antiviral agents against human SARS-CoV-2 infections remains a public health priority....
Link:
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(24)00218-X
Delivery Method:
peptide-linked; intranasal and intratracheal for mice
Organism or Cell Type:
Hela-ACE2 cells; K18-hACE2 mice
Citation Extract:
Sakai A, Singh G, Khoshbakht M, Bittner S, Löhr CV, Diaz-Tapia R, Warang P, White K, Le Luo L, Tolbert B, Blanco M, Chow A, Guttman M, Li C, Bao Y, Ho J, Maurer-Stroh S, Chatterjee A, Chanda S, García-Sastre A, Schotsaert M, Teijaro JR, Moulton HM, Stein DA. Inhibition of SARS-CoV-2 growth in the lungs of mice by a peptide-conjugated morpholino oligomer targeting viral RNA. Molecular Therapy: Nucleic Acid (2024), doi: https://doi.org/10.1016/j.omtn.2024.102331.

Prevalence of perturbed gut microbiota in pathophysiology of arsenic-induced anxiety- and depression-like behaviour in mice

Authors:
Banerjee A & Chatterji U
Citation:
Chemosphere. 2024 Sep 6:143293. doi: 10.1016/j.chemosphere.2024.143293. Online ahead of print. PMID: 39245217
Epub:
Not Epub
Abstract:
Severe toxic effects of arsenic on human physiology have been of immense concern worldwide. Arsenic causes irrevocable...
Link:
https://www.sciencedirect.com/science/article/pii/S004565352402191X
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Banerjee A & Chatterji U. Prevalence of perturbed gut microbiota in pathophysiology of arsenic-induced anxiety- and depression-like behaviour in mice. Chemosphere. 2024 Sep 6:143293. doi: 10.1016/j.chemosphere.2024.143293. Online ahead of print. PMID: 39245217.

A master regulatory loop that activates genes in a temporally coordinated manner in muscle cells of ascidian embryos

Authors:
Oda I, Satou Y
Citation:
Development. 2025 Jan 15;152(2):dev204382. doi: 10.1242/dev.204382. Epub 2025 Jan 16. PMID: 39745198
Epub:
Not Epub
Abstract:
Ascidian larval muscle cells present a classic example of autonomous development. A regulatory mechanism for these cells has...
Link:
https://journals.biologists.com/dev/article/152/2/dev204382/365015/A-master-regulatory-loop-that-activates-genes-in-a
Delivery Method:
microinjection
Organism or Cell Type:
Ciona robusta (C. intestinalis type A, ascidian)
Citation Extract:
Oda I, Satou Y. A master regulatory loop that activates genes in a temporally coordinated manner in muscle cells of ascidian embryos. Development. 2025 Jan 15;152(2):dev204382. doi: 10.1242/dev.204382. Epub 2025 Jan 16. PMID: 39745198.

Phase 1/2 trial of brogidirsen: Dual-targeting antisense oligonucleotides for exon 44 skipping in Duchenne muscular dystrophy

Authors:
Komaki H, Takeshita E, Kunitake K, Ishizuka T, Shimizu-Motohashi Y, Ishiyama A, Sasaki M, Yonee C, Maruyama S, Hida E, Aoki Y
Citation:
Cell Rep Med. 2025 Jan 21;6(1):101901. doi: 10.1016/j.xcrm.2024.101901. Epub 2025 Jan 9. PMID: 39793573; PMCID: PMC11866436
Epub:
Not Epub
Abstract:
Duchenne muscular dystrophy (DMD) is a severe muscle disorder caused by mutations in the DMD gene, leading to dystrophin...
Link:
https://www.sciencedirect.com/science/article/pii/S2666379124006724
Delivery Method:
intravenous (i.v.) infusion
Organism or Cell Type:
human
Citation Extract:
Komaki H, Takeshita E, Kunitake K, Ishizuka T, Shimizu-Motohashi Y, Ishiyama A, Sasaki M, Yonee C, Maruyama S, Hida E, Aoki Y. Phase 1/2 trial of brogidirsen: Dual-targeting antisense oligonucleotides for exon 44 skipping in Duchenne muscular dystrophy. Cell Rep Med. 2025 Jan 21;6(1):101901. doi: 10.1016/j.xcrm.2024.101901. Epub 2025 Jan 9. PMID: 39793573; PMCID: PMC11866436.

Slc4a7 Regulates Retina Development in Zebrafish

Authors:
Zhuang Y, Li D, Tang C, Zhao X, Wang R, Tao D, Huang X, Liu X
Citation:
International Journal of Molecular Sciences. 2024; 25(17):9613. https://doi.org/10.3390/ijms25179613
Epub:
Not Epub
Abstract:
Inherited retinal degenerations (IRDs) are a group of genetic disorders characterized by the progressive degeneration of...
Link:
https://www.mdpi.com/1422-0067/25/17/9613
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhuang Y, Li D, Tang C, Zhao X, Wang R, Tao D, Huang X, Liu X. Slc4a7 Regulates Retina Development in Zebrafish. International Journal of Molecular Sciences. 2024; 25(17):9613. https://doi.org/10.3390/ijms25179613.

Second generation lethality in RNAseH2a knockout zebrafish

Authors:
Thomas RC, Zaksauskaite R, Al-Kandari NY, Hyde AC, Abugable AA, El-Khamisy SF, van Eeden FJ
Citation:
Nucleic Acids Research, 2024;, gkae725, https://doi.org/10.1093/nar/gkae725
Epub:
Not Epub
Abstract:
Removal of ribonucleotides from DNA by RNaseH2 is essential for genome stability, and its impacted function causes the...
Link:
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae725/7747209
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Thomas RC, Zaksauskaite R, Al-Kandari NY, Hyde AC, Abugable AA, El-Khamisy SF, van Eeden FJ . Second generation lethality in RNAseH2a knockout zebrafish. Nucleic Acids Research, 2024;, gkae725, https://doi.org/10.1093/nar/gkae725.

Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona

Authors:
Hozumi A, Totsuka NM, Onodera A, Wang Y, Hamada M, Shiraishi A, Satake H, Horie T, Hotta K, Sasakura Y
Citation:
Elife. 2025 Jun 18;13:RP99825. doi: 10.7554/eLife.99825. PMID: 40531176; PMCID: PMC12176390
Epub:
Not Epub
Abstract:
Larvae of the ascidian Ciona initiate metamorphosis tens of minutes after adhesion to a substratum via their adhesive organ....
Link:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12176390/
Delivery Method:
microinjection
Organism or Cell Type:
Ciona robusta (C. intestinalis type A, ascidian)
Citation Extract:
Hozumi A, Totsuka NM, Onodera A, Wang Y, Hamada M, Shiraishi A, Satake H, Horie T, Hotta K, Sasakura Y. Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona. Elife. 2025 Jun 18;13:RP99825. doi: 10.7554/eLife.99825. PMID: 40531176; PMCID: PMC12176390.

Physiological and druggable skipping of immunoglobulin variable exons in plasma cells

Authors:
Ashi MO, Srour N, Lambert JM, Marchalot A, Martin O, Le Noir S, Pinaud E, Ayala MV, Sirac C, Saulière J, Moreaux J, Cogné M, Delpy L
Citation:
Cell Mol Immunol. 2019 Oct;16(10):810-819. doi: 10.1038/s41423-018-0160-6. Epub 2018 Aug 20. PMID: 30127381; PMCID: PMC6804933
Epub:
Not Epub
Abstract:
The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin (Ig) pre-mRNAs. We...
Link:
https://www.nature.com/articles/s41423-018-0160-6
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
cell culture: SK-MM-2 & RPMI 8226
Citation Extract:
Ashi MO, Srour N, Lambert JM, Marchalot A, Martin O, Le Noir S, Pinaud E, Ayala MV, Sirac C, Saulière J, Moreaux J, Cogné M, Delpy L. Physiological and druggable skipping of immunoglobulin variable exons in plasma cells. Cell Mol Immunol. 2019 Oct;16(10):810-819. doi: 10.1038/s41423-018-0160-6. Epub 2018 Aug 20. PMID: 30127381; PMCID: PMC6804933.

5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming

Authors:
Parasyraki E, Mallick M, Hatch V, Vastolo V, Musheev MU, Karaulanov E, Gopanenko A, Moxon S, Méndez-Lago M, Han D, Schomacher L, Mukherjee D, Niehrs C
Citation:
Cell. 2024 Aug 28:S0092-8674(24)00902-4. doi: 10.1016/j.cell.2024.08.011. Epub ahead of print. PMID: 39214079
Epub:
Not Epub
Abstract:
5-Methylcytosine (5mC) is an established epigenetic mark in vertebrate genomic DNA, but whether its oxidation intermediates...
Link:
https://www.cell.com/cell/abstract/S0092-8674(24)00902-4
Delivery Method:
microinjection
Organism or Cell Type:
Xenopus
Citation Extract:
Parasyraki E, Mallick M, Hatch V, Vastolo V, Musheev MU, Karaulanov E, Gopanenko A, Moxon S, Méndez-Lago M, Han D, Schomacher L, Mukherjee D, Niehrs C. 5-Formylcytosine is an activating epigenetic mark for RNA Pol III during zygotic reprogramming. Cell. 2024 Aug 28:S0092-8674(24)00902-4. doi: 10.1016/j.cell.2024.08.011. Epub ahead of print. PMID: 39214079.

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