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Morpholino Publication Database

This database contains citations and abstracts for research using Morpholino oligos, as well as some review articles incorporating Morpholino data. You can search the content using the filter boxes below.

There are 12179 scientific papers returned from the database with the search filters currently being used below.

Attenuation of Antiviral Immune Response Caused by Perturbation of TRIM25-Mediated RIG-I Activation under Simulated Microgravity

Authors:
Zhu L, Nie L, Xie S, Li M, Zhu C, Qiu X, Kuang J, Liu C, Lu C, Li W, Meng E, Zhang D, Zhu L
Citation:
Cell Rep. 2021;34(1):108600. doi:10.1016/j.celrep.2020.108600
Epub:
Not Epub
Abstract:
Microgravity is a major environmental factor of space flight that triggers dysregulation of the immune system and increases...
Link:
https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31589-8
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Zhu L, Nie L, Xie S, Li M, Zhu C, Qiu X, Kuang J, Liu C, Lu C, Li W, Meng E, Zhang D, Zhu L. Attenuation of Antiviral Immune Response Caused by Perturbation of TRIM25-Mediated RIG-I Activation under Simulated Microgravity. Cell Rep. 2021;34(1):108600. doi:10.1016/j.celrep.2020.108600.

Loss of PIGK function causes severe infantile encephalopathy and extensive neuronal apoptosis

Authors:
Chen X, Yin W, Chen S, Zhang W, Li H, Kuang H, Zhou M, Teng Y, Zhang J, Shen G, Liang D, Li Z, Hu B, Wu L
Citation:
Hum Genet. 2021 Jan 4. doi: 10.1007/s00439-020-02243-2. Online ahead of print
Epub:
Yes
Abstract:
PIGK gene, encoding a key component of glycosylphosphatidylinositol (GPI) transamidase, was recently reported to be associated...
Link:
https://link.springer.com/article/10.1007%2Fs00439-020-02243-2
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Chen X, Yin W, Chen S, Zhang W, Li H, Kuang H, Zhou M, Teng Y, Zhang J, Shen G, Liang D, Li Z, Hu B, Wu L. Loss of PIGK function causes severe infantile encephalopathy and extensive neuronal apoptosis. Hum Genet. 2021 Jan 4. doi: 10.1007/s00439-020-02243-2. Online ahead of print.

HSP60 regulates monosodium urate crystal-induced inflammation by activating the TLR4-NF- κ B-MyD88 signaling pathway and disrupting mitochondrial function

Authors:
Gao W, Huang Q, Qin T, Mu H, Long F, Ren L, Tang H, Liu J, Zeng M
Citation:
Oxid Med Cell Longev. 2020;[Epub] doi:10.1155/2020/8706898
Epub:
Yes
Abstract:
Acute gout is an inflammatory response induced by monosodium urate (MSU) crystals. HSP60 is a highly conserved stress protein...
Link:
https://www.hindawi.com/journals/omcl/2020/8706898/
Delivery Method:
Vivo-Morpholino
Organism or Cell Type:
mice
Citation Extract:
Gao W, Huang Q, Qin T, Mu H, Long F, Ren L, Tang H, Liu J, Zeng M. HSP60 regulates monosodium urate crystal-induced inflammation by activating the TLR4-NF- κ B-MyD88 signaling pathway and disrupting mitochondrial function. Oxid Med Cell Longev. 2020;[Epub] doi:10.1155/2020/8706898.

A globin-family protein, cytoglobin 1, is involved in the development of neural crest-derived tissues and organs in zebrafish

Authors:
Takahashi K, Ito Y, Yoshimura M, Nikaido M, Yuikawa T, Kawamura A, Tsuda S, Kage D, Yamasu K
Citation:
Dev Biol. 2020 Dec 22:S0012-1606(20)30325-0. doi: 10.1016/j.ydbio.2020.12.016. Online ahead of print
Epub:
Yes
Abstract:
The zebrafish is an excellent model animal that is amenable to forward genetics approaches. To uncover unknown developmental...
Link:
https://pubmed.ncbi.nlm.nih.gov/33358912/
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Takahashi K, Ito Y, Yoshimura M, Nikaido M, Yuikawa T, Kawamura A, Tsuda S, Kage D, Yamasu K. A globin-family protein, cytoglobin 1, is involved in the development of neural crest-derived tissues and organs in zebrafish. Dev Biol. 2020 Dec 22:S0012-1606(20)30325-0. doi: 10.1016/j.ydbio.2020.12.016. Online ahead of print.

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1

Authors:
Xu J, Ji L, Liang Y, Wan Z, Zheng W, Song X, Gorshkov K, Sun Q, Lin H, Zheng X, Chen J, Jin RA, Liang X, Cai X
Citation:
Signal Transduct Target Ther. 2020 Dec 26;5(1):298. doi: 10.1038/s41392-020-00375-5
Epub:
Not Epub
Abstract:
Sorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma (HCC). However, sorafenib resistance...
Link:
https://www.nature.com/articles/s41392-020-00375-5
Organism or Cell Type:
cell culture: HepG2-SR
Citation Extract:
Xu J, Ji L, Liang Y, Wan Z, Zheng W, Song X, Gorshkov K, Sun Q, Lin H, Zheng X, Chen J, Jin RA, Liang X, Cai X. CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1. Signal Transduct Target Ther. 2020 Dec 26;5(1):298. doi: 10.1038/s41392-020-00375-5.

Mutation in epsilon-Sarcoglycan Induces a Myoclonus-Dystonia Syndrome-Like Movement Disorder in Mice

Authors:
Li J, Liu Y, Li Q, Huang X, Zhou D, Xu H, Zhao F, Mi X, Wang R, Jia F, Xu F, Yang J, Liu D, Deng X, Zhang Y
Citation:
Neurosci Bull. 2020 Dec 23. doi: 10.1007/s12264-020-00612-5. Online ahead of print
Epub:
Not Epub
Abstract:
Myoclonus dystonia syndrome (MDS) is an inherited movement disorder, and most MDS-related mutations have so far been found in...
Link:
https://link.springer.com/article/10.1007/s12264-020-00612-5
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Li J, Liu Y, Li Q, Huang X, Zhou D, Xu H, Zhao F, Mi X, Wang R, Jia F, Xu F, Yang J, Liu D, Deng X, Zhang Y. Mutation in epsilon-Sarcoglycan Induces a Myoclonus-Dystonia Syndrome-Like Movement Disorder in Mice. Neurosci Bull. 2020 Dec 23. doi: 10.1007/s12264-020-00612-5. Online ahead of print.

Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects

Authors:
O'Donnell EF 3rd, Jang HS, Liefwalker DF, Kerkvliet NI, Kolluri SK
Citation:
Apoptosis. 2021 Jun;26(5-6):307-322. doi: 10.1007/s10495-021-01666-0. Epub 2021 Apr 24. PMID: 33893898
Epub:
Not Epub
Abstract:
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and a member of the bHLH/PAS (basic Helix-Loop-...
Link:
https://link.springer.com/article/10.1007/s10495-021-01666-0
Delivery Method:
peptide-linked
Organism or Cell Type:
cell culture: Hepa 1
Citation Extract:
O'Donnell EF 3rd, Jang HS, Liefwalker DF, Kerkvliet NI, Kolluri SK. Discovery and Mechanistic Characterization of a Select Modulator of AhR-regulated Transcription (SMAhRT) with Anti-cancer Effects. Apoptosis. 2021 Jun;26(5-6):307-322. doi: 10.1007/s10495-021-01666-0. Epub 2021 Apr 24. PMID: 33893898.

Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis

Authors:
Shi Y, Liu Z, Zhang Q, Vallee I, Mo Z, Kishi S, Yang X-L
Citation:
PLoS Biol. 2020;18(12):e3000991. doi:10.1371/journal.pbio.3000991
Epub:
Not Epub
Abstract:
Hypoxia-induced angiogenesis maintains tissue oxygen supply and protects against ischemia but also enhances tumor progression...
Link:
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000991
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Shi Y, Liu Z, Zhang Q, Vallee I, Mo Z, Kishi S, Yang X-L. Phosphorylation of seryl-tRNA synthetase by ATM/ATR is essential for hypoxia-induced angiogenesis. PLoS Biol. 2020;18(12):e3000991. doi:10.1371/journal.pbio.3000991.

Nrl is dispensable for specification of rod photoreceptors in adult zebrafish contrasting a deeply conserved requirement earlier in ontogeny

Authors:
Oel AP, Neil GJ, Dong EM, Balay SD, Collett K, Allison WT
Citation:
iScience. 2020;23(12):101805 doi:10.1016/j.isci.2020.101805
Epub:
Not Epub
Abstract:
The transcription factor NRL (neural retina leucine zipper) has been canonized as the master regulator of photoreceptor cell...
Link:
https://www.cell.com/iscience/fulltext/S2589-0042(20)31002-6
Delivery Method:
microinjection
Organism or Cell Type:
zebrafish
Citation Extract:
Oel AP, Neil GJ, Dong EM, Balay SD, Collett K, Allison WT. Nrl is dispensable for specification of rod photoreceptors in adult zebrafish contrasting a deeply conserved requirement earlier in ontogeny. iScience. 2020;23(12):101805 doi:10.1016/j.isci.2020.101805.

Post-transcriptional tuning of FGF signaling mediates neural crest induction

Authors:
Copeland J, Simoes-Costa M
Citation:
Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.2009997117
Epub:
Not Epub
Abstract:
Ectodermal patterning is required for the establishment of multiple components of the vertebrate body plan. Previous studies...
Link:
https://www.pnas.org/content/early/2020/12/18/2009997117
Organism or Cell Type:
Gallus gallus (chick)
Citation Extract:
Copeland J, Simoes-Costa M. Post-transcriptional tuning of FGF signaling mediates neural crest induction. Proc Nat Acad Sci USA. 2020;[Epub ahead of print] doi:10.1073/pnas.2009997117.

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